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Healthy aging (anti-aging) involves the prevention of illness and disability, keeping mental and physical activity in tip-top shape, maintaining the meaning and purpose of life. Women refuse to age and want to look younger as long as possible. The skin is the only organ which condition can be assessed visually, a peculiar mirror that reflects age-dependent changes that take place in the human body and the state of health as a whole. All regular age-dependent changes that occur at the cellular level happen in the skin, therefore, it is often used as a convenient model for studying the biological mechanisms of human aging as a whole [1]. An increase in life expectancy and a stable age of menopause has led to the fact that modern women spend more and more years in postmenopausal state. The direct effects of menopause-related sex hormone production slowing down include loss of fertility, vasomotor symptoms, and the long-term ones such as osteoporosis, cardiovascular disease (CVD) and skin aging, which causes marked discomfort, especially for women [2, 3].

The review tells about disorders which cause uterine bleeding clinically manifested in heavy menstrual bleeding combined with dysmenorrhea and changes in the central nervous system. The key pathogenetic cause of bleeding associated with endometrial dysfunction is inflammation. Hormonal therapy, being the first-choice treatment, provides a comprehensive effect on the interrelated mechanisms, demonstrates high efficacy and allows for preservation of the uterus.

Menopausal hormone therapy (MHT) is recognized as the most effective treatment of vaso-motor symptoms in women during menopausal transition and in postmenopause [1, 2]. Although various alternative therapies are widely used for this purpose, there is little sufficient evidence to support them. The market of the so-called natural plant preparations has been on the rise recently, although the effects of most of such preparations are not better than those of the placebo [3]. Many physicians and women mistakenly believe that absence of data on any adverse effects of alternative MHT medicines evidences their safety. [4]

In considering the various aspects of menopause, not enough attention is paid to a significant reduction in the quality of life for women in transition and early postmenopause. Timely administration of menopausal hormone therapy is effective in reducing menopausal symptoms and improves quality of life at a given time, as well as the risk of developing diseases of aging, that can improve the quality of life related to health, and overall well-being of women in the more distant future. The choice of medication should be determined by its composition and clinical characteristics of the particular patient.