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Your search keyword '"L S F Boogerd"' showing total 3 results
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3 results on '"L S F Boogerd"'

1. Staging laparoscopy with ultrasound and near-infrared fluorescence imaging to detect occult metastases of pancreatic and periampullary cancer.

Author

H J M Handgraaf, B G Sibinga Mulder, S Shahbazi Feshtali, L S F Boogerd, M J M van der Valk, A Fariña Sarasqueta, R J Swijnenburg, B A Bonsing, A L Vahrmeijer, and J S D Mieog

Subjects
Medicine, Science
Abstract

INTRODUCTION:Up to 38% of pancreatic and periampullary cancer patients undergoing curative intended surgery turn out to have incurable disease. Therefore, staging laparoscopy (SL) prior to laparotomy is advised to spare patients the morbidity, inconvenience and expense of futile major surgery. The aim of this study was to assess the added value of SL with laparoscopic ultrasonography (LUS) and laparoscopic near-infrared fluorescence imaging (LFI). METHODS:All patients undergoing curative intended surgery of pancreatic or periampullary cancer were included prospectively in this single arm study. Patients received an intravenous infusion of 10 mg indocyanine green (ICG) one or two days prior to surgery to allow LFI. Suspect lesions were analyzed via biopsy or resection. Follow-up visits after surgery occurred every three months. RESULTS:A total of 25 patients were included. Suspect lesions were identified in 7 patients: liver metastases (n = 2; identified by inspection, LUS, and LFI), peritoneal metastases (n = 1; identified by inspection only), and benign lesions (n = 4; identified by inspection or LUS). Quality of LFI was good in 67% (10/15) of patients dosed one day and 89% (8/9) dosed two days prior to surgery. A futile laparotomy was averted in 3 patients (12%). Following SL the primary tumor was resected in 20 patients. Two patients (10%) developed metastases within 3 months after resection. CONCLUSIONS:Despite current preoperative imaging modalities metastases are still identified during surgery. This study shows limited added value of LUS during SL in patients with pancreatic or periampullary cancer. LFI was of added value due to its high negative predictive value in case of suspect hepatic lesions identified by inspection.

Published
2018
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2. Rectal cancer lateral lymph nodes: multicentre study of the impact of obturator and internal iliac nodes on oncological outcomes

Author

Geerard L. Beets, Tsuyoshi Konishi, Jurriaan B. Tuynman, Peter H.U. Lee, C Suzuki, Atsushi Ogura, C.J.H. van de Velde, Miranda Kusters, Julio Garcia-Aguilar, K Uehara, L S F Boogerd, Dennis P. Schaap, Shigeo Toda, Tarik Sammour, Chris Cunningham, H.J.T. Rutten, In Kyu Lee, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Surgery, CCA - Cancer Treatment and quality of life, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Male, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Internal iliac lymph nodes, 030230 surgery, Pelvis, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Aged, Retrospective Studies, Rectal Neoplasms, business.industry, Hazard ratio, Cancer, Retrospective cohort study, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Survival Analysis, Radiation therapy, Dissection, medicine.anatomical_structure, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Lymph Node Excision, Female, Surgery, Lymph Nodes, Radiology, business
Abstract

Background In patients with rectal cancer, enlarged lateral lymph nodes (LLNs) result in increased lateral local recurrence (LLR) and lower cancer-specific survival (CSS) rates, which can be improved with (chemo)radiotherapy ((C)RT) and LLN dissection (LLND). This study investigated whether different LLN locations affect oncological outcomes. Methods Patients with low cT3–4 rectal cancer without synchronous distant metastases were included in this multicentre retrospective cohort study. All MRI was re-evaluated, with special attention to LLN involvement and response. Results More advanced cT and cN category were associated with the occurrence of enlarged obturator nodes. Multivariable analyses showed that a node in the internal iliac compartment with a short-axis (SA) size of at least 7 mm on baseline MRI and over 4 mm after (C)RT was predictive of LLR, compared with a post-(C)RT SA of 4 mm or less (hazard ratio (HR) 5.74, 95 per cent c.i. 2.98 to 11.05 vs HR 1.40, 0.19 to 10.20; P Conclusion Internal iliac LLN enlargement is associated with an increased LLR rate, whereas obturator nodes are associated with more advanced disease with increased distant metastasis and reduced CSS rates. LLND improves local control in persistent internal iliac nodes, and might have a role in controlling systemic spread in persistent obturator nodes. Members of the Lateral Node Study Consortium are co-authors of this study and are listed under the heading Collaborators.

Published
2021
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3. Carcinoembryonic antigen-specific, fluorescent image-guided cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for metastatic colorectal cancer

Author

D P Schaap, K S Valk, M M Deken, R P J Meijer, J Burggraaf, A L Vahrmeijer, M Kusters, L S F Boogerd, E L K Voogt, G A P Nieuwenhuijzen, H J T Rutten, I H J T de Hingh, J W A Burger, S W Nienhuijs, K S de Valk, A R M Brandt-Kerkhof, C Verhoef, E V E Madsen, J P van Kooten, B Framery, M Gutowski, A PM-hlegrin, F Cailler, I van Lijnschoten, C E S Hoogstins, Surgery, VU University medical center, and Academic Medical Center

Subjects
Adult, Male, medicine.medical_specialty, Colorectal cancer, Fluorescent Antibody Technique, Pilot Projects, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, Carcinoembryonic antigen, SDG 3 - Good Health and Well-being, Antigen, Humans, Medicine, Rapid Research Communication, Aged, Fluorescent Dyes, biology, business.industry, Optical Imaging, Intraperitoneal chemotherapy, Cytoreduction Surgical Procedures, Hyperthermia, Induced, Middle Aged, Debulking, medicine.disease, Combined Modality Therapy, Carcinoembryonic Antigen, Conventional PCI, biology.protein, Lower GI, Female, Surgery, Hyperthermic intraperitoneal chemotherapy, Radiology, Colorectal Neoplasms, Cytoreductive surgery, business
Abstract

This multicentre pilot study investigated the role of peroperative carcinoembryonic antigen (CEA)-specific fluorescence imaging during cytoreductive surgery-hyperthermic intraperitoneal chemotherapy surgery in peritoneal metastasized colorectal cancer. A correct change in peritoneal carcinomatosis index (PCI) owing to fluorescence imaging was seen in four of the 14 included patients. The use of SGM-101 in patients with peritoneally metastasized colorectal carcinoma is feasible, and allows intraoperative detection of tumour deposits and alteration of the PCI. Augmented reality guidance.

Published
2020
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