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24 results on '"L Yu, Krylova"'

3. DETERMINATION OF CRITICAL CONCENTRATION OF CHEMOTHERAPY DRUGS FOR MYCOBACTERIUM TUBERCULOSIS SENSITIVITY EVALUATION USING Sensititre MycoTB TEST SYSTEM

Author

M. V Makarova, S. G Safonova, Yu. D Isaeva, L. Yu Krylova, E. Yu Nosova, and V. I Litvinov

Subjects
sensitive and resistant mycobacterium tuberculosis strains, critical concentration, chemotherapy preparations, Microbiology, QR1-502
Abstract

Aim. Determination of critical concentration for chemotherapy drugs, widely used for tuberculosis treatment, for use in Mycobacterium tuberculosis drug sensitivity results evaluation by Sensititre MycoTB test-system. Materials and methods. Minimal inhibiting concentration (MIC) of isoniazid, rifampicin, streptomycin, ethambutol, amikacin, kanamycin, ofloxacin and moxi-floxacin against conditionally sensitive and conditionally resistant strains of tuberculosis mycobacteria (TBM), isolated from various diagnostic material, obtained from patients with various forms of lung tuberculosis being treated in MCSPCTC hospital and dispensaries for tuberculosis control of Moscow, were studied in Sensititre MycoTB test system. Results. Critical concentration of chemotherapy drugs for MycoTB test system was determined as a result of the obtained MIC values analysis as the minimal concentration that suppressed growth of 95% of sensitive strains and does not obstruct growth of 95% of resistant. The following MIC values were established: streptomycin - 1.0, isoniazid - 0.25, rifampicin - 1.0, ethambutol - 4.0, ofloxacin - 2.0, moxifloxacin - 0.25, kanamycin - 2.5 and amikacin - 1.0 pg/ml. Conclusion. The developed critical concentration of the mentioned preparations is currently used for evaluation of sensitivity/ resistance of TBM clinical isolates from MCSPCTC.

Published
2015

4. Drug susceptibility testing of M. tuberculosis with the help of test system of Sensititre MycoTB TREK Diagnostics

Author

M. V. Makarova, S. G. Safonova, L. Yu. Krylova, N. V. Litvinova, E. Yu. Nosova, and V. I. Litvinov

Subjects
определение лекарственной чувствительности, тест-система sensititre mycotb, Diseases of the respiratory system, RC705-779
Abstract

The article presents efficiency comparison of Sensititre test system and culture methods of Bactec 960 and Lowenstein-Jensen medium for drug susceptibility testing of tuberculosis mycobacteria.Cultures of M. tuberculosis of 137 patients have been studied. It has been found out that the part of coinciding results is fairly big for drug susceptibility testing by test system of Sensititre MycoTB and other methods. This system has the advantages related to standard procedures and capacity of drug susceptibility testing (degree) to 12 drugs simultaneously within a short period of time (7-14 days). Drug susceptibility testing of M. tuberculosis by testing system of Sensititre MycoTB is simpler from technical point of view compared to all other systems. Sensititre MycoTB has been tested abroad and in MSPCT and certified and it can be used for the clinical practice.

Published
2015

5. ADVANCES IN THE STUDY OF MOLECULAR BASIS OF RESISTANCE TO NEW ANTI-TB DRUGS

Author

E. Yu. Nosova, M. S. Kholina, Dmitry A. Gryadunov, Irina V. Peretokina, Danila Vadimovich Zimenkov, Olga V. Antonova, and L. Yu. Krylova

Subjects
Infectious Diseases, Resistance (ecology), business.industry, Immunology, Immunology and Allergy, Medicine, Infectious and parasitic diseases, RC109-216, Pharmacology, business
Published
2018

6. Experimental Evaluation of the Chemotherapeutic Efficacy and Toxicity of a New Medicinal Form of Dioxidine: Lidoxycol Ointment

Author

L. A. Chicherina, S. A. Sharova, T. V. Pushkina, O. S. Kuzina, and L. Yu. Krylova

Subjects
Pharmacology, stomatognathic diseases, In vivo, Chemistry, Drug Discovery, Toxicity, Pharmacology toxicology, Antimicrobial action, Antibacterial activity, eye diseases
Abstract

The antibacterial activity in vitro and in vivo and the toxicity of Lidoxycol ointment, which is a new medicinal form of dioxidine, have been studied in comparison to the properties of Dioxycol ointment. The results showed that Lidoxycol is identical to Dioxycol with respect to the spectrum of antimicrobial action, chemotherapeutic efficiency, and tolerance.

Published
2008
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7. [The detection of medication sensitivity of M.tuberculosis isolated from patients with tuberculosis with multiple medication resistance in testsystem 'Sensititre MycoTB'.]

Author

M V, Makarova, L Yu, Krylova, S G, Safonova, N V, Litvinova, E Yu, Nosova, and V I, Litvinov

Abstract

The test-system "Sensititre MycoTB" was applied to analyze 159 cultures of M.tuberculosis isolated from patients with tuberculosis. According data of investigation in "Bactec 960" they are identified as cultures with multiple medicinal sensitivity. The detailed analysis of results of application of mentioned test-system (mycoTB) demonstrated that significant part of cultures with multiple medicinal sensitivity is sensitive to anti-tuberculosis pharmaceuticals. The significant part of cultures is characterized by "intermediate" sensitivity/resistance than can be established by mentioned test-system. This data permits enlarging possibilities of chemotherapy of tuberculosis.

Published
2015

10. [Untitled]

Author

L. Yu. Krylova, V. A. Samoilenko, and T. V. Pushkina

Subjects
Pharmacology, Waste management, Chemistry, business.industry, Drug Discovery, Pharmacology toxicology, business, Steam sterilization, Biotechnology
Published
2002
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13. Synthesis and biological activity of 7,8-polymethylenepurines

Author

A. S. Sokolova, D. B. Nilov, V. G. Granik, V. V. Peters, S. G. Kalistratov, A. V. Kadushkin, L. Yu. Krylova, and I. S. Nikolaeva

Subjects
Pharmacology, business.industry, Chemistry, Drug Discovery, Pharmacology toxicology, Organic chemistry, Pharmacy, Biological activity, business
Published
1992
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18. Synthesis and antiviral activity of 5-oxyindole derivatives

Author

A. N. Fomina, L. Yu. Krylova, E. A. Golovanova, A. A. Cherkasova, N. I. Mikerova, I. S. Nikolaeva, and E. K. Panisheva

Subjects
Pharmacology, Indole test, chemistry.chemical_compound, Proton, chemistry, Drug Discovery, Pharmacology toxicology, Ring (chemistry), Benzene, Multiplet, Medicinal chemistry, Spectral line
Abstract

We had assumed that the 3-acetyl-5-acetoxyindoles (I, II) would be brominated by N-bromosuccinimide (NBS) in CCI~ at position 6 of the benzene ring in the same way that derivatives of 3-ethoxycarbonyl-5-acetoxy(methoxy)indole are brominated [4]. However, judging by the PMR spectra, substitution took place in the CH~ group at C(=) which confirms the presence of CH2Br group proton signals (5 4.99 ppm) at C(2 ) . The PMR spectrum also has proton signals at positions 4, 6, and 7 with their characteristic multiplet property.

Published
1988
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