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4 results on '"L. Kisova"'

1. Manifestation of steric factors in electrode kinetics

Author

Zbigniew Galus, L. Kisova, Jacek Lipkowski, and M. Goledzinowski

Subjects
Solvent, Steric effects, Adsorption, Pulmonary surfactant, Chemistry, Stereochemistry, Activated complex, Electrode, Physical chemistry, Molecule, Plateau (mathematics)
Abstract

The role of the steric factors in the electrode reactions occurring on the interface covered by aliphatic alcohols and acids has been investigated, taking as an example the Cd 2+ /Cd(Hg) system. It has been shown that this process takes place inside the inner layer and the activated complex is created by the replacement of r ≠ water molecules from the surface. From studies carried out at surfactant concentrations corresponding to the plateau of the adsorption isotherm the steric factors r ≠ / r i have been determined ( r i is the number of solvent molecules replaced from the surface by one molecule of adsorbed surfactant). By comparison with investigations performed at lower coverages the magnitude of r ≠ and r i has been estimated. The influence of different factors on the experimental value of these parameters has been discussed.

Published
1979
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2. On the mechanism of Cd2+ discharge from non-complexing aqueous electrolyte in presence and absence of neutral adsorbable compounds

Author

M. Goledzinowski, L. Kisova, and Jacek Lipkowski

Subjects
Cadmium, chemistry, Inorganic chemistry, Electrode, chemistry.chemical_element, Aqueous electrolyte, Amalgam (chemistry), Dissolution
Abstract

The mechanism of Cd2+ discharge and cadmium amalgam dissolution in the absence and presence of organic neutral surfactants is compared. The generality of the stepwise mechanism of this reaction occurring on Hg electrode both covered and non-covered by the surfactants is shown. The reliability of the existence of Cd+ as an intermediate in the electrode reaction is discussed.

Published
1979
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4. Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection.

Author

Bhide MR, Mucha R, Mikula I Jr, Kisova L, Skrabana R, Novak M, and Mikula I Sr

Subjects
Amino Acid Motifs genetics, Amino Acid Motifs immunology, Amino Acid Sequence, Animals, Cytokines metabolism, Dendritic Cells immunology, Dendritic Cells metabolism, Humans, Molecular Sequence Data, Mutation, Mycobacterium avium subsp. paratuberculosis immunology, Polymorphism, Single-Stranded Conformational, RNA, Messenger metabolism, Sheep immunology, Sheep microbiology, Sheep Diseases immunology, Toll-Like Receptors immunology, Paratuberculosis immunology, Sheep genetics, Sheep Diseases genetics, Toll-Like Receptors genetics
Abstract

Background: Toll like receptors (TLR) play the central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in the TLR1, TLR2 and TLR4 genes may change the ability to recognize PAMPs and cause altered responsiveness to the bacterial pathogens., Results: The study presents association between TLR gene mutations and increased susceptibility to Mycobacterium avium subsp. paratuberculosis (MAP) infection. Novel mutations in TLR genes (TLR1- Ser150Gly and Val220Met; TLR2 - Phe670Leu) were statistically correlated with the hindrance in recognition of MAP legends. This correlation was confirmed subsequently by measuring the expression levels of cytokines (IL-4, IL-8, IL-10, IL-12 and IFN-gamma) in the mutant and wild type moDCs (mocyte derived dendritic cells) after challenge with MAP cell lysate or LPS. Further in silico analysis of the TLR1 and TLR4 ectodomains (ECD) revealed the polymorphic nature of the central ECD and irregularities in the central LRR (leucine rich repeat) motifs., Conclusion: The most critical positions that may alter the pathogen recognition ability of TLR were: the 9th amino acid position in LRR motif (TLR1-LRR10) and 4th residue downstream to LRR domain (exta-LRR region of TLR4). The study describes novel mutations in the TLRs and presents their association with the MAP infection.

Published
2009
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