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3. Malattie croniche da ricercare attivamente e mettere in trattamento nel paziente anziano multimorbido al momento della dimissione da un reparto di Medicina Interna a seguito di un ricovero per insufficienza respiratoria acuta attribuita a riacutizzazione di BPCO

Author

Guest Editors: L.M. Fabbri and C. Nozzoli

Subjects
Medicine
Abstract

Introduzione P. Gnerre, L.M. Fabbri, C. Nozzoli Criteri minimi per la diagnosi, valutazione di gravità e trattamento dello scompenso cardiaco P. Gnerre BPCO e cardiopatia ischemica G. Vescovo Criteri minimi per la diagnosi, valutazione di gravità e trattamento della fibrillazione atriale D. Panuccio Criteri minimi per la diagnosi, valutazione di gravità e trattamento dell’ipertensione arteriosa M. D’Avino, G. Caruso Criteri minimi per la diagnosi, valutazione di gravità e trattamento di malattie croniche respiratorie concomitanti C. Nozzoli, L.M. Fabbri Criteri minimi per la diagnosi, valutazione di gravità e trattamento delle dislipidemie G. Imperiale Criteri minimi per la diagnosi, valutazione di gravità e trattamento del diabete F. Costanzo, L. Magnani Criteri minimi per la diagnosi, valutazione di gravità e trattamento del rischio tromboembolico F. Dentali BPCO e arteriopatia E. Maduli, E. Zoppis Criteri minimi per la diagnosi della vasculopatia cerebrale e delle malattie neurologiche degenerative nel paziente con BPCO I. Cova, S. Pomati, L. Pantoni Criteri minimi per la diagnosi, valutazione di gravità e trattamento delle tireopatie M. Grandi, C. Sacchetti, S. Pederzoli Criteri minimi per la diagnosi, valutazione di gravità e trattamento dell’osteoporosi P. Leandri, A. Cenni, S. Fiorino, G. Belmonte, R. Nardi Criteri minimi per la diagnosi, valutazione di gravità e trattamento di eventuali malattie croniche renali D. Manfellotto Criteri minimi per la diagnosi, valutazione di gravità e trattamento di eventuali epatopatie croniche L. Fontanella Criteri minimi per la diagnosi, valutazione di gravità e trattamento di eventuali malattie infiammatorie croniche dell’intestino A. Lonardo, S. Lugari Criteri minimi per la diagnosi di fragilità, disabilità e multimorbilità ed interventi generali per tutti i pazienti anziani multimorbidi (vaccinazioni, attività fisica/intellettiva, dieta, ecc.) R. Antonelli Incalzi, C. Pedone La politerapia del paziente anziano con comorbilità: problematiche in causa F. Tangianu, R. Nardi, G. Pinna, A. Sacchetta, M. Campanini Esami di laboratorio essenziali per l’inquadramento del paziente anziano multimorbido M. Pelloso, F. Tosato, M. Plebani Schemi riassuntivi

Published
2018
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5. Determinants and Clinical Implications of Persistent Airflow Limitation in Asthma: Findings from the Atlantis Small Airways Study

Author

Ian M. Adcock, J. M. Vonk, E. Vanden Berghe, Lies Lahousse, Tessa Kole, Cadset Investigators, Klaus F. Rabe, M. van den Berge, Alberto Papi, Dave Singh, Martijn C. Nawijn, Ham Kerstjens, L.M. Fabbri, Salman Siddiqui, Monica Kraft, Christopher E. Brightling, and Gabriele Nicolini

Subjects
medicine.medical_specialty, Small airways, business.industry, Asthma findings, Airflow, medicine, Intensive care medicine, business
Published
2021
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6. Unmet needs for the assessment of small airways dysfunction in asthma

Author

Dirkje S. Postma, Alberto Papi, Klaus F. Rabe, Maarten van den Berge, Thys van der Molen, Salman Siddiqui, Monica Kraft, Christopher E. Brightling, Gabriele Nicolini, Dave Singh, L.M. Fabbri, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, SYMPTOMS, Biopsy, Vital Capacity, QUESTIONNAIRE, Socio-culturale, Computed tomography, PHENOTYPES, macromolecular substances, Nitric Oxide, DISEASE, Unmet needs, INFLAMMATION, X ray computed, HYPERRESPONSIVENESS, medicine, Humans, COPD, COMPUTED-TOMOGRAPHY, Intensive care medicine, Bronchioles, Asthma, Health Services Needs and Demand, medicine.diagnostic_test, CORRELATE, business.industry, Small airways, Airway Resistance, Lung volume measurement, Forced Expiratory Flow Rates, respiratory system, medicine.disease, Respiratory Function Tests, respiratory tract diseases, Tomography x ray computed, Breath Tests, Physical therapy, Airway Remodeling, Lung Volume Measurements, Pulmonary Ventilation, Tomography, X-Ray Computed, business, CT
Abstract

Filling the knowledge gap of small airways dysfunction across all asthma severities: the ATLANTIS study http://ow.ly/LnuUL

Published
2015

8. Severe asthma in adults: What are the important questions?

Author

Christopher E. Brightling, Gary P. Anderson, Josep M. Antó, Louis-Philippe Boulet, Sven-Erik Dahlén, Isabelle Vachier, L.M. Fabbri, Mario Castro, Guy Joos, Sally E. Wenzel, Susan J. Wilson, Elisabeth H. Bel, Klaus F. Rabe, William W. Busse, Peter J. Sterk, Bruce D. Levy, Pascal Chanez, Mina Gaga, Babro Dahlen, Marc Humbert, and Stephen T. Holgate

Subjects
severe asthma, medicine.medical_specialty, Respiratory tract infections, Epidemiology, business.industry, Immunology, medicine.disease, research perspectives, Atopy, Natural history, pathophysiology, management, Immune system, Bronchial hyperresponsiveness, Internal medicine, medicine, Immunology and Allergy, business, Airway, Asthma
Abstract

The term severe refractory asthma (SRA) in adults applies to patients who remain difficult to control despite extensive re-evaluation of diagnosis and management following an observational period of at least 6 months by a specialist. Factors that influence asthma control should be recognized and adequately addressed prior to confirming the diagnosis of SRA. This report presents statements according to the literature defining SRA in order address the important questions. Phenotyping SRA will improve our understanding of mechanisms, natural history, and prognosis. Female gender, obesity, and smoking are associated with SRA. Atopy is less frequent in SRA, but occupational sensitizers are common inducers of new-onset SRA. Viruses contribute to severe exacerbations and can persist in the airways for long periods. Inflammatory cells are in the airways of the majority of patients with SRA and persist despite steroid therapy. The T(H)2 immune process alone is inadequate to explain SRA. Reduced responsiveness to corticosteroids is common, and epithelial cell and smooth muscle abnormalities are found, contributing to airway narrowing. Large and small airway wall thickening is observed, but parenchymal abnormalities may influence airway limitation. Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies.

Published
2007
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12. Early right ventricular dysfuction in smokers with COPD and reduced diffusion capacity fo caron monoxide (DLco)

Author

Verduri, A, Leuzzi, C, Barbieri, A, Roversi, P, Reggianini, L, Luppi, F, Clini, E, Fabbri, L, Modena, M, Beghe', B, A. Verduri, C Leuzzi, A. Barbieri, P Roversi, L. Reggianini, F. Luppi, E. Clini, L.M. Fabbri, M.G. Modena, B. Beghe', Verduri, A, Leuzzi, C, Barbieri, A, Roversi, P, Reggianini, L, Luppi, F, Clini, E, Fabbri, L, Modena, M, Beghe', B, A. Verduri, C Leuzzi, A. Barbieri, P Roversi, L. Reggianini, F. Luppi, E. Clini, L.M. Fabbri, M.G. Modena, and B. Beghe'

Published
2010

13. In Vitro Exposure to Nitrogen Dioxide (NO2) Does Not Alter Bronchial Smooth Muscle Responsiveness in Ovalbumin-sensitized Guinea-pigs

Author

P. Chitano, E. Coser, R.E. Lucchini, A. Papi, M. Saetta, P. Maestrelli, D. Faggian, M. Plebani, A. Ciaccia, L.M. Fabbri, and C.E. Mapp

Subjects
Male, Pulmonary and Respiratory Medicine, Allergy, medicine.medical_specialty, Ovalbumin, Neurokinin A, medicine.medical_treatment, Guinea Pigs, Nitrogen Dioxide, Bronchi, Drug Hypersensitivity, chemistry.chemical_compound, Internal medicine, medicine, Animals, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Saline, Air Pollutants, Dose-Response Relationship, Drug, biology, Chemistry, bronchial smooth muscle responsiveness, exposure, Muscle, Smooth, respiratory system, medicine.disease, Acetylcholine, Electric Stimulation, In vitro, respiratory tract diseases, Dose–response relationship, Endocrinology, Immunology, biology.protein, Airway smooth muscle, Asthma, Oxidants, Pollutants, Adjuvant, Muscle Contraction, medicine.drug
Abstract

The aim of this study was to investigate whether in vitro exposure to NO2 affects responsiveness in ovalbumin-sensitized guinea-pig bronchi. Twenty-three animals were sensitized by three weekly intraperitoneal injections of 1 mg ovalbumin in saline with Freund's adjuvant; twenty-one control guinea-pigs received the diluent alone. From each animal, the two main bronchi were obtained and cannulated, then exposed in vitro to a constant intraluminal flow of: (i) either air or 2.5 ppm NO2 with four spikes of 10 ppm NO2 for 2 h; (ii) either air or 10 ppm NO2 for 4 h. A bronchial ring obtained from each animal before exposure was kept in aerated Krebs-Henseleit solution. Rings from bronchi exposed to air, NO2, or kept in Krebs solution were studied isometrically. We performed overall and non-adrenergic non-cholinergic voltage-response curves to electrical field stimulation, concentration-response curves to acetylcholine and to neurokinin A, followed by administration of 10 mg/ml ovalbumin. We did not find any significant difference in bronchial smooth muscle responsiveness between nonexposed, air-exposed and NO2-exposed bronchi, as well as between bronchi from control and sensitized animals. We conclude that in vitro exposure to NO2 does not alter bronchial smooth muscle responsiveness to either specific or non-specific stimuli.

Published
1994

14. Contents, Vol. 54, Supplement 1, 1988

Author

R. Minisini, O. Sacco, M. Spatafora, Patricia S. Mikes, S. Poggi, A. Merendino, P. Boschetto, G.M. Corbo, A. Misiretta, S. Crescioli, A. Miadonna, P. Manganelli, A. Sala, S. Bellofiore, C.E. Mapp, G. Garavaldi, R. Polosa, M. Melis, R. Ferracini, A. Pesci, A. Cuomo, G. Chiappara, M. Froldi, L. Degli Innocenti, L. Bianco, E. Leggieri, F. Barilli, M. Anghinolfi, P. Rottoli, G.V. Marchetti, G. Bonsignore, V. Cicchetti, L. Spiga, P. Maestrelli, F. Palermo, M. Gjomarkaj, Michele R. De Musis, G.F. Consigli, F. Strinati, E. Zocca, A. Collodoro, M. Patelli, G. Bertorelli, V. Cantoni, A. Foresi, P.A. Mori, C. Ravazzoni, Lydia L. Polomski, L.M. Fabbri, Maria Robuschi, M.G. Perari, Herbert Y. Reynolds, S. Scarpa, D. Olivieri, C. Vancheri, R. Oliveri, G. U. Di Maria, G. Carriero, A. Chetta, Gianpietro Semenzato, Theodore A. Marcy, L. Rottoli, N. De Marzo, E. Marangio, S. Bianco, C. Zanussi, F. Sabino, G.C. Folco, A. Tedeschi, A. Mistretta, T. Bertanti, N. Crimi, G.A. Rossi, F. Vassallo, P.P. Dall’Aglio, Bernard L. Gee, J.G. Martin, P. Ghirardi, E. Brianti, B. Palermo, C. Brasca, V. Bellia, William Merrill, and V. Poletti

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1988
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15. Subject Index, Vol. 54, Supplement 1, 1988

Author

P. Manganelli, R. Polosa, S. Bellofiore, B. Palermo, L. Degli Innocenti, William Merrill, M. Froldi, C. Brasca, V. Bellia, P. Rottoli, G.V. Marchetti, L. Spiga, M. Melis, P.A. Mori, J.G. Martin, Lydia L. Polomski, N. De Marzo, E. Marangio, F. Strinati, N. Crimi, F. Palermo, L. Rottoli, C. Ravazzoni, Michele R. De Musis, Maria Robuschi, R. Ferracini, G.A. Rossi, S. Scarpa, E. Zocca, L. Bianco, D. Olivieri, F. Vassallo, G. Bertorelli, G. Garavaldi, G.F. Consigli, A. Merendino, F. Barilli, M.G. Perari, Gianpietro Semenzato, C. Vancheri, V. Cantoni, P. Ghirardi, A. Cuomo, Patricia S. Mikes, R. Minisini, O. Sacco, E. Brianti, Herbert Y. Reynolds, A. Foresi, A. Misiretta, S. Crescioli, A. Miadonna, S. Poggi, G. Bonsignore, Theodore A. Marcy, P. Boschetto, F. Sabino, A. Tedeschi, L.M. Fabbri, C. Zanussi, G. U. Di Maria, P. Maestrelli, M. Gjomarkaj, M. Patelli, A. Chetta, C.E. Mapp, M. Spatafora, G. Carriero, G.M. Corbo, A. Pesci, M. Anghinolfi, R. Oliveri, V. Cicchetti, G. Chiappara, Bernard L. Gee, T. Bertanti, A. Sala, E. Leggieri, A. Collodoro, V. Poletti, P.P. Dall’Aglio, G.C. Folco, A. Mistretta, and S. Bianco

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Index (economics), business.industry, Physical therapy, medicine, Subject (documents), business
Published
1988
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