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Your search keyword '"L2/L3"' showing total 4 results
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4 results on '"L2/L3"'

1. Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

Author

Sarah Hunt, Yoni Leibner, Eline J Mertens, Natalí Barros-Zulaica, Lida Kanari, Tim S Heistek, Mahesh M Karnani, Romy Aardse, René Wilbers, Djai B Heyer, Natalia A Goriounova, Matthijs B Verhoog, Guilherme Testa-Silva, Joshua Obermayer, Tamara Versluis, Ruth Benavides-Piccione, Philip de Witt-Hamer, Sander Idema, David P Noske, Johannes C Baayen, Ed S Lein, Javier DeFelipe, Henry Markram, Huibert D Mansvelder, Felix Schürmann, Idan Segev, Christiaan P J de Kock, Neurosurgery, Amsterdam Neuroscience - Systems & Network Neuroscience, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, AII - Cancer immunology, Integrative Neurophysiology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Cajal Blue Brain, École Polytechnique Fédérale de Lausanne, Ministerio de Ciencia e Innovación (España), Center for Neurogenomics and Cognitive Research (The Netherlands), European Commission, National Institutes of Health (US), and Gatsby Charitable Foundation

Subjects
local networks, Cognitive Neuroscience, l2, nmda receptors, time constants, synaptic transmission, NMDA receptor, connections, working-memory, Cellular and Molecular Neuroscience, cortex, L2/L3, l3, plasticity, pairs, impact, barrel cortex, layer 2/3, human brain
Abstract

Synaptic transmission constitutes the primary mode of communication between neurons. It is extensively studied in rodent but not human neocortex. We characterized synaptic transmission between pyramidal neurons in layers 2 and 3 using neurosurgically resected human middle temporal gyrus (MTG, Brodmann area 21), which is part of the distributed language circuitry. We find that local connectivity is comparable with mouse layer 2/3 connections in the anatomical homologue (temporal association area), but synaptic connections in human are 3-fold stronger and more reliable (0% vs 25% failure rates, respectively). We developed a theoretical approach to quantify properties of spinous synapses showing that synaptic conductance and voltage change in human dendritic spines are 3–4-folds larger compared with mouse, leading to significant NMDA receptor activation in human unitary connections. This model prediction was validated experimentally by showing that NMDA receptor activation increases the amplitude and prolongs decay of unitary excitatory postsynaptic potentials in human but not in mouse connections. Since NMDA-dependent recurrent excitation facilitates persistent activity (supporting working memory), our data uncovers cortical microcircuit properties in human that may contribute to language processing in MTG.

Published
2022

2. Establishment and optimization of packet transport network core bearer network oriented to long-term evolution business.

Author

Luo, Hongyan, Qian, Tao, Zhu, Xiangxian, Wang, Huiyin, and Yang, Jinwen

Subjects
*PACKET transport networks, *DATA transmission systems, *LONG-Term Evolution (Telecommunications), *INTERNET protocols, *TELECOMMUNICATION
Abstract

The modern telecommunication has come into the Long-Term Evolution (LTE) era. The whole transmission network gradually has evolved to the IP network. The overall network organization is likewise becoming more and more similar to the metropolitan data network. A mobile Packet Transport Network (PTN) transmission network construction is investigated. The specific bearing requirements of time division long-term evolution (TD-LTE) are analyzed. The topology structures of L3 and L2/L3 and the equipment applications in different network levels of the PTN network are discussed. The existing problems concerning the circuit scheduling, disaster tolerance requirement, security connection and business pressure are analyzed in detail. Their corresponding optimization strategies are presented. Finally, the network level having a clear, robust and complete coverage is reached. It proves that the optimized network can meet the third level of the disaster tolerance international standard SHARE 78. [ABSTRACT FROM AUTHOR]

Published
2018
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3. Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex

Author

Cajal Blue Brain, École Polytechnique Fédérale de Lausanne, Ministerio de Ciencia e Innovación (España), Center for Neurogenomics and Cognitive Research (The Netherlands), European Commission, National Institutes of Health (US), Gatsby Charitable Foundation, Hunt, Sarah, Leibner, Yoni, Mertens, Eline J., Barros-Zulaica, Natali, Kanari, Lida, Heistek, Tim S., Karnani, Masheh M., Aardse, Romy, Wilbers, René, Heyer, Djai B, Goriounova, N.A., Verhoog, M. B., Testa-Silva, Guilherme, Obermayer, Joshua, Versluis, Tamara, Benavides-Piccione, Ruth, Witt-Hamer, Philip de, Idema, Sander, Noske, David P., Baayen, Johannes C., Lein, Ed S., DeFelipe, Javier, Markram, Henry, Mansvelder, H.D., Schürmann, Felix, Segev, Idan, de Kock, C.P.J., Cajal Blue Brain, École Polytechnique Fédérale de Lausanne, Ministerio de Ciencia e Innovación (España), Center for Neurogenomics and Cognitive Research (The Netherlands), European Commission, National Institutes of Health (US), Gatsby Charitable Foundation, Hunt, Sarah, Leibner, Yoni, Mertens, Eline J., Barros-Zulaica, Natali, Kanari, Lida, Heistek, Tim S., Karnani, Masheh M., Aardse, Romy, Wilbers, René, Heyer, Djai B, Goriounova, N.A., Verhoog, M. B., Testa-Silva, Guilherme, Obermayer, Joshua, Versluis, Tamara, Benavides-Piccione, Ruth, Witt-Hamer, Philip de, Idema, Sander, Noske, David P., Baayen, Johannes C., Lein, Ed S., DeFelipe, Javier, Markram, Henry, Mansvelder, H.D., Schürmann, Felix, Segev, Idan, and de Kock, C.P.J.

Published
2022

4. Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex.

Author

Hunt S, Leibner Y, Mertens EJ, Barros-Zulaica N, Kanari L, Heistek TS, Karnani MM, Aardse R, Wilbers R, Heyer DB, Goriounova NA, Verhoog MB, Testa-Silva G, Obermayer J, Versluis T, Benavides-Piccione R, de Witt-Hamer P, Idema S, Noske DP, Baayen JC, Lein ES, DeFelipe J, Markram H, Mansvelder HD, Schürmann F, Segev I, and de Kock CPJ

Subjects
Rats, Adult, Animals, Humans, Mice, Rats, Wistar, Pyramidal Cells physiology, Synaptic Transmission physiology, Synapses physiology, Receptors, N-Methyl-D-Aspartate physiology, Neocortex
Abstract

Synaptic transmission constitutes the primary mode of communication between neurons. It is extensively studied in rodent but not human neocortex. We characterized synaptic transmission between pyramidal neurons in layers 2 and 3 using neurosurgically resected human middle temporal gyrus (MTG, Brodmann area 21), which is part of the distributed language circuitry. We find that local connectivity is comparable with mouse layer 2/3 connections in the anatomical homologue (temporal association area), but synaptic connections in human are 3-fold stronger and more reliable (0% vs 25% failure rates, respectively). We developed a theoretical approach to quantify properties of spinous synapses showing that synaptic conductance and voltage change in human dendritic spines are 3-4-folds larger compared with mouse, leading to significant NMDA receptor activation in human unitary connections. This model prediction was validated experimentally by showing that NMDA receptor activation increases the amplitude and prolongs decay of unitary excitatory postsynaptic potentials in human but not in mouse connections. Since NMDA-dependent recurrent excitation facilitates persistent activity (supporting working memory), our data uncovers cortical microcircuit properties in human that may contribute to language processing in MTG., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)

Published
2023
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