1. Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity
- Author
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Elise Météreau, Julie Thomas, Chen Qu, Michel Pugeat, Jean-Claude Dreher, Romuald Girard, Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Department of Psychology, Swansea University, Medical Research Foundation DLC20060206409, Rhone-Alpes Region 'ADR CIBLE', la region Rhone-Alpes, LABEX of Universite de Lyon, within the program 'Investissements d'Avenir' ANR-11-LABEX-0042, and Agence Nationale pour la Recherche 14-CE13-0006 16-NEUC
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[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] ,Hormone Replacement Therapy ,Brain activity and meditation ,medicine.medical_treatment ,Prefrontal Cortex ,Article ,Time-to-Treatment ,03 medical and health sciences ,Cognition ,0302 clinical medicine ,medicine ,Humans ,Dementia ,Prefrontal cortex ,thérapie hormonale ,Progesterone ,Aged ,Randomized Controlled Trials as Topic ,Behavior ,030219 obstetrics & reproductive medicine ,Multidisciplinary ,Estradiol ,business.industry ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,ménopause ,Middle Aged ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,medicine.disease ,Magnetic Resonance Imaging ,Postmenopause ,Menopause ,Dorsolateral prefrontal cortex ,Treatment Outcome ,medicine.anatomical_structure ,Cognitive remediation therapy ,Case-Control Studies ,Female ,plasma progesterone ,Hormone therapy ,progestérone ,business ,Neuroscience ,030217 neurology & neurosurgery ,Autre (Sciences du Vivant) - Abstract
Clinical data have been equivocal and controversial as to the benefits to the brain and cognition of hormone therapy (HT) in postmenopausal women. Recent reevaluation of the role of estrogens proposed that HT may effectively prevent the deleterious effects of aging on cognition, and reduces the risks of dementia, including Alzheimer’s disease, if initiated early at the beginning of menopause. Yet, little is known about the effects of HT on brain activation related to cognitive control, the ability to make flexible decisions in relation to internal goals. Here, we used fMRI to directly test for a modulation of sequential 17β estradiol (2 mg/day) plus oral progesterone (100 mg/day) on task switching-related brain activity in women at early postmenopause. The results showed that HT enhanced dorsolateral prefrontal cortex recruitment during task switching. Between-subjects correlation analyses revealed that women who engaged more the dorsolateral prefrontal cortex showed higher task switching performance after HT administration. These results suggest that HT, when taken early at the beginning of postmenopause, may have beneficial effect on cognitive control prefrontal mechanisms. Together, these findings demonstrate that HT can prevent the appearance of reduced prefrontal cortex activity, a neurophysiological measure observed both in healthy aging and early dementia.
- Published
- 2017
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