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1. Kinetics of the Reactions of NO3 Radical with alkanes

Author

Li Zhou, Abdelwahid Mellouki, Mahmoud Idir, A. R. Ravishankara, Véronique Daële, Kyle J. Zarzana, Steven S. Brown, Institut de Combustion, Aérothermique, Réactivité et Environnement (ICARE), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences de l'Ingénierie et des Systèmes (INSIS - CNRS), National Engineering Research Center for Flue Gas Desulfurization, Sichuan University [Chengdu] (SCU), Departments of Chemistry and Atmospheric Science, Colorado State University [Fort Collins] (CSU), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), NOAA Earth System Research Laboratory (ESRL), National Oceanic and Atmospheric Administration (NOAA), Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado [Boulder]-National Oceanic and Atmospheric Administration (NOAA), University of Colorado [Boulder], ARD- PIVOTS program ( supported by the Centre-Val de Loire regional council), ANR-10-LABX-0100,VOLTAIRE,Geofluids and Volatil elements – Earth, Atmosphere, Interfaces – Resources and Environment(2010), European Project: 730997,EUROCHAMP2020(2020), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences de l'Ingénierie et des Systèmes (INSIS), Sichuan University, Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), ANR-10-LABX-100-01/10-LABX-0100,VOLTAIRE,Geofluids and Volatil elements – Earth, Atmosphere, Interfaces – Resources and Environment(2010), European Project: 730997,EUROCHAMP2020, Institut de Combustion, Aérothermique, Réactivité et Environnement ( ICARE ), Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut des Sciences de l'Ingénierie et des Systèmes ( INSIS ), Colorado State University [Fort Collins] ( CSU ), LE STUDIUM ( LE STUDIUM ), Bureau de Recherches Géologiques et Minières (BRGM) ( BRGM ) -Institut National de la Recherche Agronomique ( INRA ) -CEMAGREF-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique ( CNRS ), NOAA Earth System Research Laboratory ( ESRL ), National Oceanic and Atmospheric Administration ( NOAA ), Cooperative Institute for Research in Environmental Sciences ( CIRES ), University of Colorado Boulder [Boulder]-National Oceanic and Atmospheric Administration ( NOAA ), University of Colorado Boulder [Boulder], ANR-10-LABX-100-01/10-LABX-0100,VOLTAIRE,Geofluids and Volatil elements – Earth, Atmosphere, Interfaces – Resources and Environment ( 2010 ), and European Project : 730997,EUROCHAMP2020

Subjects
Cyclohexane, Chemistry, Radical, Kinetics, Enthalpy, Analytical chemistry, General Physics and Astronomy, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Methane, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, chemistry.chemical_compound, Deuterium, 13. Climate action, Propane, [ CHIM.OTHE ] Chemical Sciences/Other, [ CHIM.THEO ] Chemical Sciences/Theoretical and/or physical chemistry, Physical and Theoretical Chemistry, 0210 nano-technology, Cyclopentane, [CHIM.OTHE]Chemical Sciences/Other
Abstract

The rate coefficients for the reactions of NO3 radicals with methane (CH4), ethane (C2H6), propane (C3H8), n-butane (n-C4H10), iso-butane (iso-C4H10), 2,3-dimethylbutane (C6H14), cyclopentane (C5H10) and cyclohexane (C6H12) at atmosphere pressure (1000 ± 5 hPa) and room temperature (298 ± 1.5 K) were measured using an absolute method. Careful attention was paid to the role of secondary reactions and impurities. The upper limits of rate coefficients for methane and ethane at 298 K are

Published
2019

2. Closeups of a not-so-domestic mite tritonymph

Author

Uzbekov, Rustem, Bouakaz, Ayache, Postema, Michiel, Tampere University, BioMediTech, Université de Tours (UT), UMR 1253 IBrain Imagerie & Cerveau Equipe 3 'Imagerie, Biomarqueurs & Thérapie' (IBT), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), BioMediTech Institute [Tampere], University of Tampere [Finland], University of the Witwatersrand [Johannesburg] (WITS), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, Immunology and Allergy, 217 Medical engineering
Abstract

publishedVersion Non

Published
2023

3. RNA-seq analysis of the active chick embryo chorioallantoic membrane reveals genes that encode proteins assigned to ion transport and innate immunity

Author

Maeva Halgrain, Nelly Bernardet, Christelle Hennequet-Antier, Maxwell Hincke, Sophie Réhault-Godbert, Biologie des Oiseaux et Aviculture (BOA), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Ottawa [Ottawa], LE STUDIUM (LE STUDIUM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], Calcium metabolism, Genetics, Immunity, Chorioallantoic membrane, Genetic variability, Transcriptomics, Chicken
Abstract

International audience; The chicken chorioallantoic membrane (CAM) is an extraembryonic membrane that is vital for the embryo. It undergoes profound cell differentiation between 11 and 15 days of embryonic incubation (EID), which corresponds to the acquisition of its physiological functions. To gain insight into the functional genes that accompany these biological changes, RNA sequencing of the CAM at EID11 and EID15 was performed. Results showed that CAM maturation coincides with the overexpression of 4225 genes, including many genes encoding proteins involved in mineral metabolism, innate immunity, homeostasis, angiogenesis, reproduction, and regulation of hypoxia. Of these genes, some exhibit variability in expression depending on the chicken breed (broiler versus layer breeds). Besides the interest of these results for the poultry sector, the identification of new functional gene candidates opens additional research avenues in the field of developmental biology.

Published
2023

4. Numerical simulations of high viscosity DNAPL recovery in highly permeable porous media under isothermal and non-isothermal conditions

Author

Hossein Davarzani, Nicolas Philippe, Maxime Cochennec, Stéfan Colombano, Malorie Dierick, Behzad Ataie-Ashtiani, Pierre-Yves Klein, Manuel Marcoux, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), REMEA, LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Institut de mécanique des fluides de Toulouse (IMFT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université de Toulouse (UT)

Subjects
2D tank, Viscosity, Non-isothermal, Wettability, Dense non-aqueous phase liquid, Environmental Chemistry, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Porosity, Water Pollutants, Chemical, Two-phase flow, Coal tar, Water Science and Technology, Thermally enhanced DNAPL recovery
Abstract

International audience; We developed a decimetric size model based on coupling generalized Darcy's law and heat-transfer equations to model viscous dense non-aqueous phase liquid (DNAPL) pumping through highly permeable porous media under non-isothermal conditions. The presence of fingering and non-wetting phase ganglia was modeled through an unsteady capillary diffusion coefficient and an arbitrary heterogeneous permeability field. The model was validated using existing experimental data of a simple case, an oil injection in a 2D tank packed with glass beads. Next, we compared the results of this model against a DNAPL extracting situation in the 2D tank to better understand the two-phase flow behavior in highly permeable porous media. We found that natural convection during heating plays an essential role in heat transfer, especially in the wetting phase zone. By adding the dynamic effect (unsteady conditions) we were better able to describe the presence of the ganglia in porous media. We observed good agreement between modeled and experimental oil saturation curves until the breakthrough point, with a mean relative error of about 10% for low and high flow rates, and 8% and 16% after breakthrough for low and high flow rates, respectively. Extracting viscous oil at low flow rates and high temperature generates less fingering and is well described by the generalized Darcy's law. The remobilization of residual non-wetting ganglia after the breakthrough point at the outlet is, however, difficult to simulate using the generalized Darcy's law. In the end, we treated this issue by using a perturbed permeability field to simulate the observed fingering in the 2D tank.

Published
2022

5. Charge distribution and dynamics of nanoparticles during the plasma afterglow

Author

Denysenko, Igor, Mikikian, Maxime, V.N. Karazin Kharkiv National University (KhNU), Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Mikikian, Maxime

Subjects
Dust charging, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [PHYS.PHYS.PHYS-PLASM-PH] Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, Afterglow plasma, [SPI.PLASMA] Engineering Sciences [physics]/Plasmas, Nanoparticles, Charge distribution, Modelling, Dusty plasmas
Abstract

International audience

Published
2022

6. Conflits environnementaux et gestion des espaces : Modalités de recours au tribunal, pratiques administratives et logiques d'acteurs entre environnement et aménagement

Author

Romain Melot, ANNE CADORET, Philippe Jeanneaux, Thierry Kirat, Hai Vu Pham, Clovis Sabau, Sciences pour l'Action et le Développement : Activités, Produits, Territoires ( SADAPT ), Institut National de la Recherche Agronomique ( INRA ) -AgroParisTech, Théoriser et modéliser pour aménager ( ThéMA ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), LE STUDIUM ( LE STUDIUM ), Bureau de Recherches Géologiques et Minières (BRGM) ( BRGM ) -Institut National de la Recherche Agronomique ( INRA ) -CEMAGREF-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique ( CNRS ), Centre d'Economie de l'Université Paris Nord ( CEPN ), Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -Centre National de la Recherche Scientifique ( CNRS ), INRA, Institut National de la Recherche Agronomique ( INRA ), Dauphine Recherches en Management ( DRM ), Université Paris-Dauphine-Centre National de la Recherche Scientifique ( CNRS ), GIP Mission de recherche droit et justice, Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Théoriser et modéliser pour aménager (UMR 6049) (ThéMA), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), LE STUDIUM (LE STUDIUM), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Centre d'Economie de l'Université Paris Nord (CEPN), Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS), Dauphine Recherches en Management (DRM), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), AgroParisTech-Institut National de la Recherche Agronomique (INRA), and Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Université de Franche-Comté (UFC)

Subjects
[SHS.GEO]Humanities and Social Sciences/Geography, [ SHS.GEO ] Humanities and Social Sciences/Geography
Abstract

133http://www.gip-recherche-justice.fr/IMG/pdf/179-RF_Melot_Conflits_Environ.pdf; Les conflits environnementaux sont devenus l'objet d'un nombre important de travaux issus des différentes disciplines des sciences sociales, si l'on s'en tient simplement au cadre des recherches menées en France. La production scientifique française sur la thématique des conflits d'usage des espaces et des conflits environnementaux, telle qu'elle ressort des recensions bibliographiques (Caron, Rialland, 2001) ou d'ouvrages rassemblant des contributions sur le sujet (Melé, 2004; Kirat, Torre, 2008) montre la diversité des sujets abordés et des méthodes sollicitées. Il ressort de ces éléments de recension que de nombreux travaux (sociologiques, géographiques, économiques) sont centrés sur les acteurs des conflits, au travers d'entretiens, d'observations, d'analyse de périodiques ou de documents associatifs (pour un exemple de sociologie de l'action associative, cf. Barthélémy, Weber, 1993). Ces travaux peuvent s'appuyer sur des études quantitatives, comme lorsqu'il s'agit de mettre en évidence, sur une base géographique et statistique, des typologies dans l'apparition, la fréquence et la durée de certains conflits environnementaux - cf.les travaux s'appuyant sur le dépouillement de la presse associative (Charlier, 1999). D'autres s'intéressent aux arrangements informels ou institutionnels visant à régler ces conflits environnementaux par le biais d'analyses monographiques approfondies au niveau d'un territoire, de manière à saisir les logiques d'acteurs qui s'expriment en dehors, en marge, ou dans le prolongement du cadre administratif et judiciaire (Beuret, 2006).

Published
2008

7. Postharvest Treatment of Wood Biomass from a Large Collection of European Grape Varieties: Impact on the Selection of Polyphenol-Rich Byproducts

Author

Magdalena Anna Malinowska, Arnaud Lanoue, Kévin Billet, Thibaut Munsch, Audrey Oudin, Sébastien Besseau, Marianne Unlubayir, Vincent Courdavault, Thomas Dugé de Bernonville, Nathalie Giglioli-Guivarc’h, Biomolécules et biotechnologies végétales (BBV EA 2106), Université de Tours (UT), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Cracow University of Technology, This research was partly supported by LE STUDIUM - Institute for Advanced Studies, Loire Valley, Orléans, France, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Université de Tours

Subjects
2. Zero hunger, Renewable Energy, Sustainability and the Environment, [SDV]Life Sciences [q-bio], General Chemical Engineering, Polyphenols, Biomass, 02 engineering and technology, General Chemistry, Biology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Horticulture, Polyphenol, Germplasm collection, Postharvest, Waste Biomass, Environmental Chemistry, Postharvest treatment, Ranking, Grape canes, Viticulture, 0210 nano-technology, Selection (genetic algorithm)
Abstract

International audience; Grape canes are viticulture byproducts representing a sustainable source of valuable bioactive polyphenols. However, varietal origin and postharvest treatment greatly influence the effective concentration of biomolecules, thus limiting industrial development. With the aim to develop grape cane extracts with high polyphenol contents, the selection of a specific grape variety combined with optimized postharvest treatment is the major determinant. A previously described postharvest treatment comprising cutting grapevine stalks of 0.5 cm length and storage at 15–20 °C over 2 weeks was applied on a selection of 44 grape varieties representative of the genetic diversity of the whole European collection and performing the screening of polyphenol contents. Varietal rankings according to major polyphenols (catechin, epicatechin, E-resveratrol, E-piceatannol, E-ϵ-viniferin, E-miyabenol C, ampelopsin A, E-vitisin B, hopeaphenol, and isophopeaphenol) were performed with and without the postharvest treatment. We observed that postharvest treatment greatly influenced the total polyphenol composition but also the ranking of polyphenol-rich varieties. This polyphenol screening of grape canes from a large collection of European varieties revealed the importance of postharvest treatment together with the selection of varieties to develop natural extracts based on grapevine wood biomass enriched with molecules with health benefits.

Published
2021

8. Dust charge distribution in a plasma afterglow

Author

Denysenko, Igor, Mikikian, Maxime, Mikikian, Maxime, T. Klinger, J. Hobirk, S. Orlando, L. Lancia, D. Maric, E. Westerhof, V.N. Karazin Kharkiv National University (KhNU), Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)

Subjects
Dust charging, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [PHYS.PHYS.PHYS-PLASM-PH] Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, Afterglow plasma, [SPI.PLASMA] Engineering Sciences [physics]/Plasmas, Charge distribution, Modelling, Dusty plasmas
Abstract

International audience

Published
2022

9. Structural modifications of the chorioallantoic membrane and the inner eggshell during chicken embryonic development

Author

Halgrain, Maëva, Bernardet, Nelly, Georgeault, Sonia, Hincke, Maxwell, Réhault-Godbert, Sophie, REHAULT-GODBERT, Sophie, Biologie des Oiseaux et Aviculture (BOA), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Plateforme IBISA de Microscopie Electronique [CHRU de Tours] (UNIV Tours), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT), University of Ottawa [Ottawa], LE STUDIUM (LE STUDIUM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

International audience; In oviparous species, the egg contains protective systems and provides energy and nutrients that support the development of the embryo until hatching. During embryonic development, extraembryonic structures are vital to assimilate egg nutrients, to protect the embryo, to ensure gaseous exchange and to accumulate metabolic waste. The chorioallantoic membrane (CAM), which develops in close contact with the inner eggshell from day 5 of incubation, is a highly vascularized structure. The CAM is located between the eggshell membranes (ESM, outer side) and the allantoic fluid that collects embryonic waste (inner side). The CAM was reported to be involved in decalcification of the inner eggshell and mineral transport from the eggshell to the embryo (for mineralization of its skeleton), in acid-base homeostasis, and in ion and H2O reabsorption from the allantoic fluid. To decipher the kinetics of its structural maturation, we compared the structure of the inner and outer surfaces of the CAM by electron microscopy. In parallel, ESM and the eggshell were analyzed to better appreciate the impact of CAM development on its surrounding structures. Eggs from Ross 308 broiler hens were incubated for 11 or 15 days (ED11 vs ED15, early and mature stage of CAM development, respectively). At each time point, eggs were broken, and the eggshell, ESM and the CAM were gently separated for analysis by scanning electron microscopy. Images corresponding to the cross-section and the inner side of the eggshell, eggshell membranes (ESM, outer and inner sides) and CAM (outer and inner sides) were obtained. At ED15, results showed that the inner side of the eggshell is degraded (decalcification) during embryonic development while the mammillary knobs of the eggshell remain tightly attached to the external membrane of the ESM. The CAM also undergoes major structural changes with some villous cells that emerge from its outer surface to reach the eggshell membrane and the eggshell. The molecular components associated with eggshell decalcification and mineral transport from the eggshell to the embryo via CAM’s vasculature remain essentially unknown. This study has been recently complemented by a transcriptomic analysis of the CAM (RNA sequencing) at these two developmental stages. Altogether, we believe that the combined findings of this work will lead to better understanding of CAM functions that are vital for embryonic development and skeletal mineralization during incubation.

Published
2022

10. Modeling results on the dust charge distribution in a plasma afterglow

Author

I. B. Denysenko, M. Mikikian, N. A. Azarenkov, V.N. Karazin Kharkiv National University (KhNU), Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Le Studium

Subjects
[PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, Condensed Matter Physics, 52.27.Lw
Abstract

International audience; Discharging of dust particles in an argon plasma afterglow is investigated using different approaches. First, the dust charge distribution function (DCDF) is obtained by solving numerically the master equation describing dust discharging as a one-step stochastic process. Second, the DCDF is calculated as a Gaussian distribution with mean dust charge and variance, which are functions of time. Additionally, the time-dependencies for the mean dust charge are obtained assuming that the charge changes continuously in the afterglow plasma. Calculation results are compared with available experimental data and are found to be in good qualitative agreement if the dust discharging model accounts for the emission of electrons in the collisions of excited argon atoms with dust particles. This study is carried out taking into account the transition from ambipolar to free diffusion as well as multistep ionization, excitation, and deexcitation of argon atoms in the plasma afterglow.

Published
2022

11. Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism

Author

Emmanuel Saridakis, Rishi Vishwakarma, Josephine Lai-Kee-Him, Kevin Martin, Isabelle Simon, Martin Cohen-Gonsaud, Franck Coste, Patrick Bron, Emmanuel Margeat, Marc Boudvillain, National Center for Scientific Research 'Demokritos' (NCSR), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Centre de Biologie Structurale [Montpellier] (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ANR-15-CE11-0024,IntegRhoMe,Toward an Integrated View of Transcription Terminator Rho Functions and Mechanisms(2015), Boudvillain, Marc, and Toward an Integrated View of Transcription Terminator Rho Functions and Mechanisms - - IntegRhoMe2015 - ANR-15-CE11-0024 - AAPG2015 - VALID

Subjects
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], QH301-705.5, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Cryoelectron Microscopy, Medicine (miscellaneous), Mycobacterium tuberculosis, Bridged Bicyclo Compounds, Heterocyclic, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Rho Factor, General Biochemistry, Genetics and Molecular Biology, 3. Good health, Biology (General), [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, General Agricultural and Biological Sciences, Transcription Factors
Abstract

The bacterial Rho factor is a ring-shaped motor triggering genome-wide transcription termination and R-loop dissociation. Rho is essential in many species, including in Mycobacterium tuberculosis where rho gene inactivation leads to rapid death. Yet, the M. tuberculosis Rho [MtbRho] factor displays poor NTPase and helicase activities, and resistance to the natural Rho inhibitor bicyclomycin [BCM] that remain unexplained. To address these issues, we solved the cryo-EM structure of MtbRho at 3.3 Å resolution. The MtbRho hexamer is poised into a pre-catalytic, open-ring state wherein specific contacts stabilize ATP in intersubunit ATPase pockets, thereby explaining the cofactor preference of MtbRho. We reveal a leucine-to-methionine substitution that creates a steric bulk in BCM binding cavities near the positions of ATP γ-phosphates, and confers resistance to BCM at the expense of motor efficiency. Our work contributes to explain the unusual features of MtbRho and provides a framework for future antibiotic development.

Published
2022

12. Modelling of argon-acetylene dust-forming plasma

Author

Denysenko, I. B., Erik von Wahl, Maxime Mikikian, Johannes Berndt, Holger Kersten, Eva Kovacevic, Mikikian, Maxime, Vulcanisation adhésive assistée par plasma - - Plasma-Bond2017 - ANR-17-CE08-0018 - AAPG2017 - VALID, V.N. Karazin Kharkiv National University (KhNU), Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Le Studium Loire Valley Institute for Advanced Studies [Orléans, France], Institut für Experimentelle und Angewandte Physik [Kiel] (IEAP), Christian-Albrechts-Universität zu Kiel (CAU), ANR-18-CE30-0016,MONA,De la MOlécule à la NAnoparticule : Couplage expériences/modèles pour révéler la physico-chimie complexe des plasmas hydrocarbonés(2018), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Institute of Experimental and Applied Physics [Kiel] (IEAP), and ANR-17-CE08-0018,Plasma-Bond,Vulcanisation adhésive assistée par plasma(2017)

Subjects
Reactive plasmas, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Acetylene, [PHYS.PHYS.PHYS-PLASM-PH] Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, Nanoparticles, [SPI.PLASMA] Engineering Sciences [physics]/Plasmas, Nanoparticle Formation, ComputingMilieux_MISCELLANEOUS, Modelling, Dusty plasmas
Abstract

International audience; The properties of an Ar/C2H2 dusty plasma (neutral, ion and electron densities, effective electron temperature and dust charge) are studied using a volume-averaged model. The steady-state plasma is considered, as well as the case when the dust radius varies with time in the same way as in our experiments. It is analysed how different process conditions (absorbed power, input flux of acetylene, electron energy distribution function and nanoparticle density) affect the plasma properties. The results of our calculations are compared with our experimental results on growth of nanoparticles in an Ar/C2H2 plasma and the results are found to be in a good qualitative agreement.

Published
2022

13. Modelling of argon/dust pulsed plasma

Author

Denysenko, I. B., Stefanovic, Ilija, Mikikian, Maxime, Kovacevic, Eva, Berndt, Johannes, V.N. Karazin Kharkiv National University (KhNU), Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Mikikian, Maxime, and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Physics::Plasma Physics, electron energy probability function (EEPF), [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [PHYS.PHYS.PHYS-PLASM-PH] Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, [SPI.PLASMA] Engineering Sciences [physics]/Plasmas, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, argon/dust pulsed plasma, complex mixtures, Astrophysics::Galaxy Astrophysics, ComputingMilieux_MISCELLANEOUS
Abstract

A spatially-averaged model for an argon/dust pulsed plasma is developed in this study [1]. We analyze how the plasma properties depend on the shape of the electron energy probability function (EEPF), the pulsing frequency and the duty cycle. In addition, the case of dust-free plasma is considered. It is found that the results of theory and experiment agree better if the assumed EEPF has a Druyvesteyn shape instead of a Maxwellian one. As an example, we compare electron and metastable atom densities for different plasma states. In particular, the model shows that in the presence of dust and at some pulsing frequencies the electron density decreases rapidly in the very beginning of the on-period. In our opinion, this decrease is due to an enhancement of electron collection by dust particles at the beginning of the on- period. Further, variation in the pulsing frequency differently affects the metastable density in a dust-free and in a dusty plasma. For large pulsing frequencies (≥ 7 kHz), the metastable density in presence of dust is smaller than in the continuous-wave discharge, contrary to the dust-free case. Our model shows that the collection of electrons by dust particles causes the faster variation of the effective electron temperature leading to the lower metastable density. Using a 1D model we describe the plasma properties during the off-period (afterglow) also. The charge of a dust particle and the forces affecting the dust particle are studied for different neutral gas pressures and dust radii. It is found that at long afterglow times, the electric force affects more essentially the dust particle than the ion drag force. These results on dusty pulsed plasmas are relevant to many applications involving nonstationary plasmas containing impurities such as those for synthesis of novel nanomaterials.

Published
2021

14. Hydrogen isotopic fractionations during syntheses of lipid biomarkers in the seeds of broomcorn millet (Panicum miliaceum L.) under controlled environmental conditions

Author

Patricia Richard, Nicolas Bossard, Valery J. Terwilliger, Claude Le Milbeau, Elisabeth Vergès, Philippe Biron, Jérémy Jacob, Thierry Bariac, Institut des Sciences de la Terre d'Orléans - UMR7327 (ISTO), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Biogéosystèmes Continentaux - UMR7327, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Géochrononologie Traceurs Archéométrie (GEOTRAC), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Kansas [Kansas City], Simon Fraser University (SFU.ca), Ministère de la Recherche et de l’Enseignement Supérieur (Action Thématique Prioritaire, 2009-2012)., Le Studium® (Loire Institute for Advanced Studies)., ANR-10-JCJC-0607,PalHydroMil,Reconstructions paléohydrologiques à partir du dD de lipides produits par les végétaux supérieurs. Calibration, validation et application aux variations hydrologiques dans les Alpes pendant l'âge du Bronze(2010), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), POTHIER, Nathalie, and Jeunes Chercheuses et Jeunes Chercheurs - Reconstructions paléohydrologiques à partir du dD de lipides produits par les végétaux supérieurs. Calibration, validation et application aux variations hydrologiques dans les Alpes pendant l'âge du Bronze - - PalHydroMil2010 - ANR-10-JCJC-0607 - JCJC - VALID

Subjects
010504 meteorology & atmospheric sciences, Hydrogen, chemistry.chemical_element, Biosynthetic fractionation hydrogen isotopes Panicum miliaceum Biogeochemical chambers compound-specific δ2H, Fractionation, Leaf water, 010502 geochemistry & geophysics, Graminoid, 01 natural sciences, GEOF, [SDU] Sciences of the Universe [physics], Triterpene, Geochemistry and Petrology, Relative humidity, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, 0105 earth and related environmental sciences, chemistry.chemical_classification, Panicum miliaceum, biology, Chemistry, food and beverages, miliacin, biology.organism_classification, [SDU.ENVI] Sciences of the Universe [physics]/Continental interfaces, environment, [SDU]Sciences of the Universe [physics], Environmental chemistry, biomarker, Lipid biomarkers
Abstract

International audience; Compound specific hydrogen isotopic analyses have the potential to reveal the biosynthetic pathways of biomarkers and to reconstruct the effects of water stress in a plant, or in an ecosystem. Although C4 graminoids are of great geological interest and are some of the world's leading crops, there are few experimental studies of their biomarker responses to hydrological conditions. Here, we study a C4 graminoid, broomcorn millet, and compare the effects of controlled changes in environmental conditions on the distributions of n-alkane homologues and on the pentacyclic triterpene, miliacin, which is a biomarker for broomcorn millet; both were measured in the seeds of the graminoid. Broomcorn millet plants were propagated in hydroponic solutions with four different δ2H values for each of two growth chambers, differing in relative humidity (58 and 74 %). Analyses of δ2H values of the lipid compounds (miliacin and n-alkanes) in seeds and water extracted from transpiring and non-transpiring organs allowed us to quantify the apparent (lipids vs. source water to plant) and biosynthetic (lipids vs. leaf water) fractionations during miliacin and n-alkane syntheses. Miliacin and n-alkane δ2H values were linearly related to leaf water δ2H values, permitting credible biosynthetic fractionations to be calculated for n-alkanes (average -149.5‰ ± 11) and miliacin (-118‰ ± 5). These biosynthetic fractionations were within the range of published values for compounds with their respective biosynthetic pathways, although a 2H-enrichment of miliacin compared to n-alkanes remains unexplained.Whereas a 16% decrease in relative humidity had no significant impact on the biosynthetic fractionation of miliacin, n-C25 and n-C27 alkanes, it led to a ∼25‰ decrease in biosynthetic fractionation for n-C31 and n-C33 alkanes. This could be the consequence of a contribution of more depleted pools of hydrogen atoms in cytoplasmic water (compared to chloroplastic hydrogen pools) during the n-alkyl lipid elongation process. This finding suggests that the respective influences of source water δ2H values and relative humidity on the δ2H values of organic compounds may be discretely inferred by examining the δ2H values of compounds synthesized from distinct sources of hydrogen in cells. It provides clues to the biosynthetic fractionations in a C4 plant for compounds derived from distinct pathways, but also highlights specific issues related to seed lipids that would require further research.

Published
2021

15. Argon/dust and pure argon pulsed plasmas explored using a spatially-averaged model

Author

Maxime Mikikian, Johannes Berndt, Igor Denysenko, Eva Kovacevic, Ilija Stefanovic, V.N. Karazin Kharkiv National University (KhNU), Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Le Studium, Mikikian, Maxime, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)

Subjects
Electron density, Dusty plasma, Materials science, Acoustics and Ultrasonics, chemistry.chemical_element, Electron, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, complex mixtures, 010305 fluids & plasmas, chemistry.chemical_compound, argon/dust pulsed plasmas, Physics::Plasma Physics, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Metastability, 0103 physical sciences, argon pulsed plasmas, Astrophysics::Solar and Stellar Astrophysics, pulsing frequency, plasma, Dusty plasmas, 010302 applied physics, Argon, Acetylene, [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, Modeling, [SPI.PLASMA] Engineering Sciences [physics]/Plasmas, Plasma, Condensed Matter Physics, dust particles, electron energy probability function, EEPF, spatially-averaged model, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Complex plasmas, chemistry, [PHYS.PHYS.PHYS-PLASM-PH] Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Reactive gases, duty cycle, Electron temperature, Pulsed plasmas, Astrophysics::Earth and Planetary Astrophysics, Atomic physics
Abstract

The properties (densities of electrons and metastable argon atoms, effective electron temperature and dust charge) of argon/dust and pure argon pulsed plasmas are studied using a spatially-averaged model. The calculated time-dependencies for the densities of electrons and metastable atoms are compared with the experimental measurements and are found to be in a good qualitative agreement. It is analyzed how the plasma properties depend on the shape of the electron energy probability function (EEPF), the pulsing frequency and the duty cycle for both dust-free and dusty plasma. The analysis reveals that the agreement between theory and experiment is better with Druyvesteyn EEPF than the Maxwellian EEPF. Further, the variation in the pulsing frequency νp differently affects the metastable density nm in a dust-free and in a dusty plasma. For large νp, the metastable density in the dust-free pulsed plasma is larger than in the continuous-wave (CW) discharge, while the opposite is obtained in the presence of dust particles. This difference probably arises because of faster variation in the effective electron temperature in the dusty plasma due to collection of electrons by dust particles. Our calculations also show that dust particles may affect the behavior of electron density in the beginning of the on-period due to an enhancement in electron collection by dust particles. This is the peer-reviewed version of the article: Denysenko I. B., Stefanović Ilija, Mikikian M., Kovačević E., Berndt J., "Argon/dust and pure argon pulsed plasmas explored using a spatially-averaged model" Journal of Physics D: Applied Physics, 54, no. 6 (2021):065202, [https://doi.org/10.1088/1361-6463/abc210]. Published version: [https://hdl.handle.net/21.15107/rcub_dais_9988]

Published
2021

16. Ensino, pesquisa e extensão universitaria sobre a otica do design para inovação social

Author

Beany Guimarães Monteiro, LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Federal University Rio de Janeiro, Ecole Supérieure d'art et de design d'Orléans (ESAD), This research was partly supported by LE STUDIUM - Institute for Advanced Studies, Loire Valley, Orléans, France., Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Class (computer programming), Reflection (computer programming), Design, business.industry, 4. Education, media_common.quotation_subject, Teaching, Research, Social innovation, Structuring, Fine art, [SHS]Humanities and Social Sciences, New graduate, Extension, Pedagogy, ComputingMilieux_COMPUTERSANDEDUCATION, Sociology, business, Autonomy, media_common, Research method
Abstract

International audience; This article presents the report of a research carried out during the postdoctoral program, which focused on the peda-gogical practices used for teaching Design for Social Innovation, with the objective of structuring the course of Ecosocial Design, a class to be taught to undergraduate college students majoring in Design in Brazil. To develop the search in this period, it was initiated a reflection on the creation and application of the Postgraduate Program in Design at the School of Fine Arts of the Federal University of Rio de Janeiro. The research method was based on the combination of the intrinsic and extrinsic aspects of the intermediate objects that are need to the creation of this Program with the ped-agogical instruments developed during its organization, and the potential of these instruments to participate associ-atively in the creation of new Graduate Programs in Brazil. It was determined that the preservation of the autonomy of the knowledge accrued in different contexts, according to the principle of individuation of the Intermediate Objects of Conception, is potentially capable of reducing territorial inequalities by strengthening their associations, and thus performing a coordinating role of associative forms.

Published
2020

17. Ensino, pesquisa e extensão universitaria sobre a otica do design para inovação social

Author

Monteiro, Beany Guimarães, LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Federal University Rio de Janeiro, Ecole Supérieure d'art et de design d'Orléans (ESAD), This research was partly supported by LE STUDIUM - Institute for Advanced Studies, Loire Valley, Orléans, France., and Studium, Le

Subjects
Design, Extension, Teaching, Research, Social innovation, [SHS] Humanities and Social Sciences, [SHS]Humanities and Social Sciences
Abstract

International audience; This article presents the report of a research carried out during the postdoctoral program, which focused on the peda-gogical practices used for teaching Design for Social Innovation, with the objective of structuring the course of Ecosocial Design, a class to be taught to undergraduate college students majoring in Design in Brazil. To develop the search in this period, it was initiated a reflection on the creation and application of the Postgraduate Program in Design at the School of Fine Arts of the Federal University of Rio de Janeiro. The research method was based on the combination of the intrinsic and extrinsic aspects of the intermediate objects that are need to the creation of this Program with the ped-agogical instruments developed during its organization, and the potential of these instruments to participate associ-atively in the creation of new Graduate Programs in Brazil. It was determined that the preservation of the autonomy of the knowledge accrued in different contexts, according to the principle of individuation of the Intermediate Objects of Conception, is potentially capable of reducing territorial inequalities by strengthening their associations, and thus performing a coordinating role of associative forms.

Published
2020

18. Freezing Weakens the Barrier Function of Reconstructed Human Epidermis as Evidenced by Raman Spectroscopy and Percutaneous Permeation

Author

Christophe Eklouh-Molinier, Yuri Dancik, Franck Bonnier, Hichem Kichou, Emilie Munnier, Martin Soucé, Igor Chourpa, Nanomédicaments et Nanosondes, EA 6295 (NMNS), Université de Tours (UT), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Tours

Subjects
Kinetics, Analytical chemistry, Pharmaceutical Science, lcsh:RS1-441, Resorcinol, freezing, Article, lcsh:Pharmacy and materia medica, storage, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, symbols.namesake, 0302 clinical medicine, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, reconstructed human epidermis, Stratum corneum, medicine, skin barrier, resorcinol, Barrier function, 030304 developmental biology, 0303 health sciences, Aqueous solution, Epidermis (botany), Chemistry, Permeation, medicine.anatomical_structure, 13. Climate action, Raman spectroscopy, symbols, permeation, EpiSkin™
Abstract

The development and characterization of reconstructed human epidermis (RHE) is an active area of R&amp, D. RHE can replace animal tissues in pharmaceutical, toxicological and cosmetic sciences, yielding scientific and ethical advantages. RHEs remain costly, however, due to consumables and time required for their culture and a short shelf-life. Storing, i.e., freezing RHE could help reduce costs but to date, little is known on the effects of freezing on the barrier function of RHE. We studied such effects using commercial EpiSkin&trade, RHE stored at &minus, 20, &minus, 80 and &minus, 150 &deg, C for 1 and 10 weeks. We acquired intrinsic Raman spectra in the stratum corneum (SC) of the RHEs as well as spectra obtained following topical application of resorcinol in an aqueous solution. In parallel, we quantified the effects of freezing on the permeation kinetics of resorcinol from time-dependent permeation experiments. Principal component analyses discriminated the intrinsic SC spectra and the spectra of resorcinol-containing RHEs, in each case on the basis of the freezing conditions. Permeation of resorcinol through the frozen RHE increased 3- to 6-fold compared to fresh RHE, with the strongest effect obtained from freezing at &minus, 20 &deg, C for 10 weeks. Due to the extensive optimization and standardization of EpiSkin&trade, RHE, the effects observed in our work may be expected to be more pronounced with other RHEs.

Published
2020
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19. Shifted-Chebyshev-polynomial-based numerical algorithm for fractional order polymer visco-elastic rotating beam

Author

Yiming Chen, Lei Wang, Nanyang Technological University [Singapour], Department of Information Management, Chang Jung Christian University, Laboratoire pluridisciplinaire de recherche en ingénierie des systèmes, mécanique et énergétique (PRISME), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), This research was partly supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Studium, Le

Subjects
Chebyshev polynomials, Fractional visco-elastic rotating beam, General Mathematics, Operator matrix, Numerical solution, General Physics and Astronomy, [MATH] Mathematics [math], 01 natural sciences, 010305 fluids & plasmas, Matrix (mathematics), Integer, Shifted Chebyshev polynomials, Collocation method, 0103 physical sciences, Time domain, [MATH]Mathematics [math], 010301 acoustics, Mathematics, Fractional governing equation, Basis (linear algebra), Applied Mathematics, Approximation technique, Statistical and Nonlinear Physics, Fractional calculus, Algebraic equation, Algorithm
Abstract

This is the accepted version of the following article: "Shifted-Chebyshev-polynomial-based numerical algorithm for fractional order polymer visco-elastic rotating beam", which has been published in final form at https://www.sciencedirect.com/science/article/pii/S0960077919305429#!; International audience; In this paper, an effective numerical algorithm is proposed for the first time to solve the fractional visco-elastic rotating beam in the time domain. On the basis of fractional derivative Kelvin-Voigt and fractional derivative element con-stitutive models, the two governing equations of fractional visco-elastic rotating beams are established. According to the approximation technique of shifted Chebyshev polynomials, the integer and fractional differential operator matrices of polynomials are derived. By means of the collocation method and matrix technique, the operator matrices of governing equations can be transformed into the algebraic equations. In addition, the convergence analysis is performed. In particular, unlike the existing results, we can get the displacement and the stress numerical solution of the governing equation directly in the time domain. Finally, the sensitivity of the algorithm is verified by numerical examples.

Published
2020

20. Transcriptomics supports local sensory regulation in the antenna of the kissing-bug Rhodnius prolixus

Author

Marcos Sterkel, Jose Manuel Latorre-Estivalis, Marcelo G. Lorenzo, Sheila Ons, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Centro Regional de Estudios Genómicos [universidad Nacional de La Plata, Argentina] (CREG-UNLP), Universidad Nacional de la Plata [Argentine] (UNLP), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790Authors are indebted to INCTEM (Project number: 573959/2008–0), FAPEMIG (Project number: APQ-01359-11), PROEP-FIOCRUZ (Project number: 401973/2012–3), CNPq (Project number: 483805/2013–0), Le Studium for a granting research fellowship to MGL (Short Term Contract of Employment N° 2017–2001-179 - Y17F16), FIOCRUZ Visiting researcher fellowship program (fellowship to JML-E 550017/2015–17), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) postdoctoral fellowship (fellowship to JML-E 2015–2017) and Agencia Nacional de Promoción Científica y Tecnológica (Project number: PICT 2016–3103). JML-E., MS and SO are researchers from CONICET. All these funds provided financial support in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript., The authors wish to thank the Program for Technological Development in Tools for Health-PDTIS-FIOCRUZ for having facilitated the use of its facilities. We wish to thank Ivana Helena Rocha Oliveira for her help in processing samples used in our experiments, Prof. Claudio Lazzari for kindly providing comments on an earlier version of the manuscript, and Dr. Gabriel da Rocha Fernandes and Fausto Gonçalves dos Santos for their help and support in the bioinformatic analyses, Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Receptors, Neuropeptide, KISSING-BUGS, Biología, [SDV]Life Sciences [q-bio], Insect, purl.org/becyt/ford/1 [https], transcriptomics, 0302 clinical medicine, Gene expression, Phylogeny, media_common, Neurotransmitter Agents, 0303 health sciences, biology, Gene Expression Regulation, Developmental, Receptors, Neurotransmitter, 3. Good health, Cell biology, medicine.anatomical_structure, Larva, Rhodnius, Insect Proteins, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], DNA microarray, Neurohormones, Research Article, Biotechnology, Arthropod Antennae, ANTENNAE, kissing-bugs, lcsh:QH426-470, lcsh:Biotechnology, NEUROPEPTIDES, media_common.quotation_subject, Sensory system, 03 medical and health sciences, lcsh:TP248.13-248.65, Genetics, medicine, Animals, TRANSCRIPTOMICS, purl.org/becyt/ford/1.6 [https], Rhodnius prolixus, Gene, 030304 developmental biology, Sequence Analysis, RNA, Gene Expression Profiling, neuropeptides, biology.organism_classification, antennae, Sensory neuron, lcsh:Genetics, Nuclear receptor, Neuroscience, 030217 neurology & neurosurgery
Abstract

Background: Rhodnius prolixus has become a model for revealing the molecular bases of insect sensory biology due to the publication of its genome and its well-characterized behavioural repertoire. Gene expression modulation underlies behaviour-triggering processes at peripheral and central levels. Still, the regulation of sensory-related gene transcription in sensory organs is poorly understood. Here we study the genetic bases of plasticity in antennal sensory function, using R. prolixus as an insect model. Results: Antennal expression of neuromodulatory genes such as those coding for neuropeptides, neurohormones and their receptors was characterized in fifth instar larvae and female and male adults by means of RNA-Sequencing (RNASeq). New nuclear receptor and takeout gene sequences were identified for this species, as well as those of enzymes involved in the biosynthesis and processing of neuropeptides and biogenic amines. Conclusions: We report a broad repertoire of neuromodulatory and neuroendocrine-related genes expressed in the antennae of R. prolixus and suggest that they may serve as the local basis for modulation of sensory neuron physiology. Diverse neuropeptide precursor genes showed consistent expression in the antennae of all stages studied. Future studies should characterize the role of these modulatory components acting over antennal sensory processes to assess the relative contribution of peripheral and central regulatory systems on the plastic expression of insect behaviour., Centro Regional de Estudios Genómicos

Published
2020

21. Calling Behavior and Sex Pheromone Release and Storage in the Moth Chloridea virescens

Author

Karin G. Anderson, Jérôme Casas, Stephen P. Foster, Institut de recherche sur la biologie de l'insecte UMR7261 (IRBI), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), This research was partly supported by LE STUDIUM - Institute for Advanced Studies, Loire Valley, Orléans, France, Université de Tours-Centre National de la Recherche Scientifique (CNRS), and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
0106 biological sciences, Male, Empirical data, [SDV]Life Sciences [q-bio], Zoology, Chloridea, Biology, Moths, 01 natural sciences, Biochemistry, Gas Chromatography-Mass Spectrometry, Lepidoptera genitalia, Sexual Behavior, Animal, mass isotopomer distribution analysis, Animals, Scent Glands, Sex Attractants, Ecology, Evolution, Behavior and Systematics, Collection methods, Aldehydes, Carbon Isotopes, titer, Catabolism, catabolism, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, General Medicine, biology.organism_classification, Lepidoptera, 010602 entomology, Glucose, Sex pheromone, Isotope Labeling, Pheromone, Ovipositor, Female, biosynthesis, 010606 plant biology & botany, Pheromone gland
Abstract

This is the post-print version of the following article: "Calling Behavior and Sex Pheromone Release and Storage in the Moth Chloridea virescens", which has been published in final form at https://link.springer.com/article/10.1007/s10886-019-01133-w#auth-1; International audience; Female moths release sex pheromone to attract mates. In most species, sex pheromone is produced in, and released from, a specific gland. In a previous study, we used empirical data and compartmental modeling to account for the major pheromone gland processes of female Chloridea virescens: synthesis, storage, catabolism and release; we found that females released little (20–30%) of their pheromone, with most catabolized. The recent publication of a new pheromone collection method led us to reinvestigate pheromone release and catabolism in C. virescens on the basis that our original study might have underestimated release rate (thereby overestimating catabolism) due to methodology and females not calling (releasing) continuously. Further we wished to compare pheromone storage/catabolism between calling and non-calling females. First, we observed calling intermittency of females. Then, using decapitated females, we used the new collection method, along with compartmental modeling, gland sampling and stable isotope labeling, to determine differences in pheromone release, catabolism and storage between (forced) simulated calling and non-calling females. We found, (i) intact 1 d females call intermittently; (ii) pheromone is released at a higher rate than previously determined, with simulations estimating that continuously calling females release ca. 70% of their pheromone (only 30% catabolized); (iii) extension (calling)/retraction of the ovipositor is a highly effective “on/off’ mechanism for release; (iv) both calling and non-calling females store most pheromone on or near the gland surface, but calling females catabolize less pheromone; (v) females are capable of producing and releasing pheromone very rapidly. Thus, not only is the moth pheromone gland efficient, in terms of the proportion of pheromone released Vs. catabolized, but it is highly effective at shutting on/off a high flux of pheromone for release.

Published
2020

22. Agrobiological Interactions of Essential Oils of Two Menthol Mints: Mentha piperita and Mentha arvensis

Author

Agnieszka Synowiec, Danuta Kalemba, Institute of Natural Products and Cosmetics [Lodz University of Technology, Poland], LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Agroecology and Crop Production [University of Agriculture in Kraków, Poland], This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Studium, Le

Subjects
0106 biological sciences, Mentha arvensis, Pharmaceutical Science, Review, Biology, Agricultural pest, 01 natural sciences, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, Drug Discovery, Oils, Volatile, Plant Oils, chemical composition, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Physical and Theoretical Chemistry, agriculture, business.industry, Plant Extracts, Organic Chemistry, Mentha piperita, Pesticide, biology.organism_classification, 0104 chemical sciences, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 010404 medicinal & biomolecular chemistry, Horticulture, Menthol, chemistry, Chemistry (miscellaneous), Agriculture, Molecular Medicine, botanical pesticides, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 010606 plant biology & botany, Mentha
Abstract

International audience; This review article discusses the active constituents and potential of two menthol mint oils, Mentha piperita (MPEO) and Mentha arvensis (MAEO), as natural sources for botanical pesticides. The biological activities of these menthol mint oils, which can be useful in agriculture, have been broadly researched, especially toward phytotoxic microorganisms. To a lesser extent, the insecticidal and herbicidal activities of mint EOs have also been studied. It is apparent that the prospect of using menthol mint oils in agriculture is increasing in popularity. A number of investigations showed that the in vitro efficacy of MPEO and MAEO, as well as that of their main constituent, menthol, is pronounced. The results of in vitro research are useful for choosing EOs for further investigations. However, it is clear that in situ experiments are crucial and should be more extensively developed. At the same time, known techniques are to be applied to this area and new methods should be worked out, aiming at the improvement of EOs' pesticidal efficacy and cost-effectiveness, for future implementation in agricultural pest control.

Published
2020

23. Database for the kinetics of the gas-phase atmospheric reactions of organic compounds

Author

M. R. McGillen, W. P. L. Carter, A. Mellouki, J. J. Orlando, B. Picquet-Varrault, T. J. Wallington, Institut de Combustion, Aérothermique, Réactivité et Environnement (ICARE), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences de l'Ingénierie et des Systèmes (INSIS - CNRS), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), University of California [Riverside] (UC Riverside), University of California (UC), Earth Observing Laboratory [Boulder] (EOL), National Center for Atmospheric Research [Boulder] (NCAR)-University Corporation for Atmospheric Research (UCAR), Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Research and Innovation Center, Ford (Ford Motor Company), ANR-10-LABX-0100,VOLTAIRE,Geofluids and Volatil elements – Earth, Atmosphere, Interfaces – Resources and Environment(2010), European Project: 730997,EUROCHAMP2020(2020), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences de l'Ingénierie et des Systèmes (INSIS), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of California [Riverside] (UCR), University of California, Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHAUVEAU, Christian, Laboratoires d'excellence - Geofluids and Volatil elements – Earth, Atmosphere, Interfaces – Resources and Environment - - VOLTAIRE2010 - ANR-10-LABX-0100 - LABX - VALID, and European Union’s Horizon 2020 research and innovation programme under grant agreement - EUROCHAMP2020 - 2020-12-01 - 2020-06-30 - 730997 - VALID

Subjects
010504 meteorology & atmospheric sciences, [SDE.MCG]Environmental Sciences/Global Changes, 0211 other engineering and technologies, DIMETHYL ETHER, 02 engineering and technology, 010501 environmental sciences, computer.software_genre, 01 natural sciences, Gas phase, Atmospheric reactions, CHEMISTRY, ACTIVITY-RELATIONSHIP SAR, OH RADICALS, HYDROXYL RADICAL REACTION, lcsh:Environmental sciences, 021102 mining & metallurgy, 021101 geological & geomatics engineering, 0105 earth and related environmental sciences, lcsh:GE1-350, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Primary (chemistry), Database, [SDU.OCEAN] Sciences of the Universe [physics]/Ocean, Atmosphere, lcsh:QE1-996.5, PHOTOCHEMICAL DATA, HETEROGENEOUS REACTIONS, lcsh:Geology, [SDE.MCG] Environmental Sciences/Global Changes, TEMPERATURE-DEPENDENCE, General Earth and Planetary Sciences, RATE COEFFICIENTS, computer, TERT-BUTYL ETHER
Abstract

We present a digital, freely available, searchable, and evaluated compilation of rate coefficients for the gas-phase reactions of organic compounds with OH, Cl, and NO3 radicals and with O3. Although other compilations of many of these data exist, many are out of date, most have limited scope, and all are difficult to search and to load completely into a digitized form. This compilation uses results of previous reviews, though many recommendations are updated to incorporate new or omitted data or address errors, and includes recommendations on many reactions that have not been reviewed previously. The database, which incorporates over 50 years of measurements, consists of a total of 2765 recommended bimolecular rate coefficients for the reactions of 1357 organic substances with OH, 709 with Cl, 310 with O3, and 389 with NO3, and is much larger than previous compilations. Many compound types are present in this database, including naturally occurring chemicals formed in or emitted to the atmosphere and anthropogenic compounds such as halocarbons and their degradation products. Recommendations are made for rate coefficients at 298 K and, where possible, the temperature dependences over the entire range of the available data. The primary motivation behind this project has been to provide a large and thoroughly evaluated training dataset for the development of structure–activity relationships (SARs), whose reliability depends fundamentally upon the availability of high-quality experimental data. However, there are other potential applications of this work, such as research related to atmospheric lifetimes and fates of organic compounds, or modelling gas-phase reactions of organics in various environments. This database is freely accessible at https://doi.org/10.25326/36 (McGillen et al., 2019).

Published
2020

24. Pleotropism of gonadotropin action

Author

Simoni, Manuela, Paradiso, Elia, Lockhart, Véronique, Reiter, Eric, Casarini, Livio, Pellissier, Lucie, Crépieux, Pascale, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790, Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Gonadotropin action, LH, endocrine system, Granulosa cells, FSHR, FOS: Biological sciences, [SDV]Life Sciences [q-bio], FSH, FOS: Health sciences, infertility, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

LE STUDIUM Multidisciplinary Journal. This is the final version of the article, which has been published in final form at http://www.lestudium-ias.com/content/pleotropism-gonadotropin-action-0; International audience; Evidence exists that the gonadotropins LH and FSH can substitute to each other under certain circumstances, in addition to the fact that they can act together in granulosa cells. The aim of this study is to investigate how the two human gonadotropins influence each other in granulosa cells expressing both receptors, or by co-culturing cells expressing either the LHCGR or the FSHR (as a model granulosa/theca interaction). Plasmids encoding the c-myc-tagged-LHCGR and the FLAG-tagged FSHR under the control of an inducible coumermycin-responsive or doxycycline-responsive promoter, respectively were produced. These plasmids were used to permanently transfect human granulosa cell-derived KGN cells and HEK293 cells. The following cell lines were obtained and partially characterized: #1 c-myc-tagged-LHCGR-KGN; #2 FLAG-tagged FSHR_HEK293; #3 FLAG-tagged FSHR-KGN; #4 Double, c-myc-tagged-LHCGR and FLAG-tagged FSHR-KGN. After induction of receptor expression, the cell lines #1 and #2 and #3 responded to hCG and FSH stimulation, respectively by producing cAMP. Receptor expression was demonstrated by RT-PCR and flow cytometry. The characterization of the cell line #4 is ongoing. These cell lines are now available for the study of cell signaling and steroid synthesis, as well as in silico modeling, to gain insight into the dynamics of the intertwined cell response to FSH and LH in granulosa cells. These experiments will continue in parallel in both laboratories involved. Our cell lines represent new, very valuable instruments for the study of molecular pharmacology of FSH and LH, in order to improve infertility treatment, (multi)follicular growth for assisted reproduction, ovulation and spermatogenesis.

Published
2020

25. Molecular bases of sensory processes in kissing bugs, vectors of Chagas disease

Author

Marcelo G. Lorenzo, Jose Manuel Latorre-Estivalis, Centro Regional de Estudios Genómicos [universidad Nacional de La Plata, Argentina] (CREG-UNLP), Universidad Nacional de la Plata [Argentine] (UNLP), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790Authors are indebted to INCT de Entomologia Molecular (CNPq Project 465678/2014-9), FAPEMIG (Project number: APQ-01359-11), CNPq (Project number: 483805/2013-0), Le Studium for granting a research fellowship to M.G.L (Short Term Contract of Employment N° 2017-2001-179 - Y17F16), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) postdoctoral fellowship (fellowship to J.M.L.E 2015-2017) and Agencia Nacional de Promoción Científica y Tecnológica (Project number: PICT 2016-3103)., Fundação Oswaldo Cruz (FIOCRUZ), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
0106 biological sciences, 0301 basic medicine, Chagas disease, Communication, Sensory Receptor Cells, business.industry, [SDV]Life Sciences [q-bio], fungi, Sensation, Sensory system, Biology, medicine.disease, 010603 evolutionary biology, 01 natural sciences, Insect Vectors, 3. Good health, 03 medical and health sciences, 030104 developmental biology, Rhodnius, Insect Science, medicine, Animals, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], business, Ecology, Evolution, Behavior and Systematics
Abstract

International audience; Sensory processes represent an information gathering interface between animals and their surrounding world. Therefore, they serve to scan the environment for resources and threats. The behavior of kissing bugs has been studied to aid their control because they transmit Chagas disease to humans. Besides, a few triatomines represent important insect models since Wigglesworth times. These hematophagous insects rely on different sensory systems to scan their environment for blood-sources, mating partners and hiding places. The study of the molecular bases of sensory processes has undergone a dramatic progress due the advent of new technologies allowing mass-sequencing of genes. Here we focus on reviewing the fundamental knowledge gathered to date about the molecular bases of kissing bug sensory processes.

Published
2019

26. Combining Proprioceptive Neuromuscular Facilitation and Virtual Reality for Improving Sensorimotor Function in Stroke Survivors: A Randomized Clinical Trial

Author

Matheus de Sales Santos, Nildo Manoel da Silva Ribeiro, Igor Lima Maldonado, Vitor Antônio dos Santos Junior, LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Studium, Le

Subjects
030506 rehabilitation, medicine.medical_specialty, medicine.medical_treatment, hemiplegia, Virtual reality, lcsh:RC346-429, law.invention, rehabilitation, virtual rehabilitation, rehabilitation research, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Randomized controlled trial, law, medicine, physical therapy, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Stroke survivor, Stroke, lcsh:Neurology. Diseases of the nervous system, Original Research, stroke rehabilitation, Rehabilitation, Proprioception, business.industry, medicine.disease, stroke, Facilitation, Virtual rehabilitation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract

Aim: To assess a program combining virtual reality (VR) games and proprioceptive neuromuscular facilitation (PNF) and to compare it with the standalone techniques in stroke survivors. Methods: A randomized controlled clinical trial. A total of 48 participants were recruited in the outpatient clinic of a University Hospital in Salvador, Brazil. They were randomly assigned to 3 groups (n = 16 each): PNF, VR, and PNF/VR. Participants attended twice-weekly 50-minute sessions over a 2-month period. The PNF/VR group performed both PNF and VR exercises employing Nintendo Wii electronic games. Motor performance was assessed before and immediately after the treatment using the Fugl-Meyer Assessment scale. Results: An improvement in the mean scores was observed after treatment independent of the allocation group with significant intragroup changes: 14.5, 10.5, and 10.4 for PNF, VR, and PNF/VR, respectively. Score changes were also observed in the analyses of specific sections as follows: (1) a significant improvement in the passive movement and pain score was observed in the PNF and PNF/VR groups; (2) the same was observed for the motor function of the upper limb in all groups, for the motor function of the lower limb in the VR group and for balance in the PNF and PNF/VR groups. Conclusions: The use of a program combining virtual rehabilitation and PNF presented results that were comparable with those obtained with the isolated techniques.

Published
2019

27. Numerical solutions of generalized fractional pantograph equations with variable coefficients using shifted Chebyshev polynomials

Author

Wang, Li-Ping, Chen, Yi-Ming, Liu, Da-Yan, Boutat, Driss, Department of Information Management, Chang Jung Christian University, Laboratoire pluridisciplinaire de recherche en ingénierie des systèmes, mécanique et énergétique (PRISME), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA), and This research was partly supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France

Subjects
Error analysis, Numerical solution, ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION, Operational matrix, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Generalized fractional pantograph equations
Abstract

International audience; In this paper, an efficient numerical technique based on the shifted Chebyshev polynomials (SCPs) is established to obtain numerical solutions of generalized fractional pantograph equations with variable coefficients. These polynomials are orthogonal and have compact support on [0, L]. We use these polynomi-als to approximate the unknown function. Using the properties of the SCPs, we derive the generalized pantograph operational matrix of SCPs and the one of fractional-order differentiation. Then the original problems can be transformed to a system of algebraic equations based on these matrices. By solving these algebraic equations, we can obtain numerical solutions. In addition, we investigate the error analysis and introduce the process of error correction for improving the precision of numerical solutions. Lastly, by giving some examples and comparing with other existing methods, the validity and efficiency of our method is demonstrated.

Published
2019

28. Numerical algorithm to solve generalized fractional pantograph equations with variable coefficients based on shifted Chebyshev polynomials

Author

Li-Ping Wang, Da-Yan Liu, Driss Boutat, Yiming Chen, Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA), Laboratoire pluridisciplinaire de recherche en ingénierie des systèmes, mécanique et énergétique (PRISME), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Department of Information Management, Chang Jung Christian University, LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and This research was partly supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France

Subjects
Chebyshev polynomials, Applied Mathematics, Numerical solution, Numerical technique, Operational matrix, 010103 numerical & computational mathematics, 01 natural sciences, Computer Science Applications, 010101 applied mathematics, Computational Theory and Mathematics, Error analysis, ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION, Applied mathematics, Pantograph, 0101 mathematics, ComputingMilieux_MISCELLANEOUS, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Variable (mathematics), Mathematics, Generalized fractional pantograph equations
Abstract

International audience; In this paper, an efficient numerical technique based on the shifted Chebyshev polynomials (SCPs) is established to obtain numerical solutions of generalized fractional pantograph equations with variable coefficients. These polynomials are orthogonal and have compact support on [0, L]. We use these polynomi-als to approximate the unknown function. Using the properties of the SCPs, we derive the generalized pantograph operational matrix of SCPs and the one of fractional-order differentiation. Then the original problems can be transformed to a system of algebraic equations based on these matrices. By solving these algebraic equations, we can obtain numerical solutions. In addition, we investigate the error analysis and introduce the process of error correction for improving the precision of numerical solutions. Lastly, by giving some examples and comparing with other existing methods, the validity and efficiency of our method is demonstrated.

Published
2019

29. Physical principles of medical ultrasound

Author

Klaus-Vitold Jenderka, Spiros Kotopoulis, Michiel Postema, University of the Witwatersrand [Johannesburg] (WITS), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Haukeland University Hospital, University of Bergen (UiB), Hochschule Merseburg, Christoph F. Dietrich, Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Postema, Michiel, and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
010302 applied physics, medicine.medical_specialty, business.industry, 0103 physical sciences, medicine, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Medical physics, business, 010301 acoustics, 01 natural sciences, Medical ultrasound, ComputingMilieux_MISCELLANEOUS
Abstract

Michiel Postema, Spiros Kotopoulis, Klaus-Vitold Jenderka. Physical principles of medical ultrasound. Christoph F. Dietrich.EFSUMB Course Book 2nd Edition, pp.1-23, 2019. DOI:10.37713/ECB01

Published
2019

30. Ultrasonic identification technique in recycling of lithium ion batteries

Author

Satyajit Phadke, Michiel Postema, Cuthbert Nyamupangedengu, Anthony Novell, Ayache Bouakaz, Rustem Uzbekov, Mérièm Anouti, Postema, Michiel, University of the Witwatersrand [Johannesburg] (WITS), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physico-chimie des Matériaux et des Electrolytes pour l'Energie (PCM2E), Université de Tours (UT), Plateforme IBISA de Microscopie Electronique [CHRU de Tours] (UNIV Tours), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT), Lomonosov Moscow State University (MSU), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Le Studium Loire Valley Institute for Advanced Studies, 45000 Orléans, France, Université de Tours, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Département des Microscopies, plate-forme R.I.O. de microscopie électronique, Université Francois Rabelais [Tours], This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)-Université de Tours

Subjects
FOS: Computer and information sciences, Sound (cs.SD), Materials science, cathode separation, chemistry.chemical_element, FOS: Physical sciences, 02 engineering and technology, Applied Physics (physics.app-ph), 01 natural sciences, 7. Clean energy, Signal, Computer Science - Sound, Lithium-ion battery, law.invention, Ion, ultrasonic particle manipulation, law, Audio and Speech Processing (eess.AS), 0103 physical sciences, FOS: Electrical engineering, electronic engineering, information engineering, lithium ion battery recycling, cathode material identification, 010302 applied physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], Scattering, harmonic imaging, Physics - Applied Physics, 021001 nanoscience & nanotechnology, Cathode, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Chemical engineering, chemistry, Harmonic, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Ultrasonic sensor, Lithium, 0210 nano-technology, Electrical Engineering and Systems Science - Audio and Speech Processing
Abstract

The recycling of lithium ion batteries has been mentioned as one of the near-future waste management necessities. In order for recycling to be economically viable, straightforward and cost effective techniques need to be developed to separate the individual materials in a composite electrode. Ultrasonic separation might be such a technique, provided that lithium ion battery microparticles respond predictably to a sound field. Lithium ion battery cathodes contain hydrophobic carbon. Owing to the incompressibility of a solid, the thin gaseous layer surrounding these hydrophobic particles must oscillate asymmetrically, when subjected to ultrasound. Consequently, the harmonic content of the ultrasound signal radiated from hydrophobic microparticles must be higher than that from hydrophilic microparticles with the same size. The question of whether the harmonic signal response generated by physical hydrophobic microparticles present in lithium ion battery cathodes is higher than the harmonic response of other component materials in the cathode is the focus of this paper. The scattering response of cathode materials subjected to 1-MHz ultrasound was measured and compared. The cathode materials C65, PVDF, and NMC respond differently to 1-MHz ultrasound. The superharmonic response of C65 has been attributed to asymmetric oscillations owing to its hydrophobicity. In addition, C65 hydrophobic microparticles might be suitable candidates for harmonic imaging., Comment: 4 pages, 6 figures, submitted as a Proceeding to the IEEE AFRICON 2019 conference

Published
2019

31. JSWSC: recent developments and further advances

Author

Jurgen Watermann, Jean Lilensten, Anna Belehaki, Agnès Henri, Jan Janssens, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), National Observatory of Athens (NOA), LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Hôpitaux Universitaires de Genève (HUG), Inconnu, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Sciences, EDP

Subjects
Atmospheric Science, Engineering, 010504 meteorology & atmospheric sciences, business.industry, lcsh:QC851-999, 01 natural sciences, Space and Planetary Science, 0103 physical sciences, lcsh:Meteorology. Climatology, business, [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract

International audience; No abstract available

Published
2019

32. Feature in product engineering with single and variant design approaches. A comparative review

Author

Pedro Rosado, Stefano Borgo, Fernando Romero, Sergio Benavent, Emilio M. Sanfilippo, Universitat Jaume I, LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Centre d'études supérieures de la Renaissance UMR 7323 (CESR), Ministère de la Culture et de la Communication (MCC)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratory for Applied Ontology - LOA (Trento, Italy), This research was partly supported by LE STUDIUM - Institute for Advanced Studies, Loire Valley, Orléans, France, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ministère de la Culture et de la Communication (MCC)-Université de Tours-Centre National de la Recherche Scientifique (CNRS), and Studium, Le

Subjects
0209 industrial biotechnology, Class (computer programming), domain engineering Keywords: product variant modelling, classical engineering, Product design, Computer science, Context (language use), 02 engineering and technology, Product engineering, Data science, Industrial and Manufacturing Engineering, Field (computer science), feature definitons, domain engineering, [SHS]Humanities and Social Sciences, 020303 mechanical engineering & transports, 020901 industrial engineering & automation, 0203 mechanical engineering, Conceptual framework, Artificial Intelligence, Feature (machine learning), product variant modelling, Domain engineering, [SHS] Humanities and Social Sciences, feature models
Abstract

International audience; The paper contributes to the study of feature concept by analyzing its use in techniques and models of both classical product engineering and product engineering with variants. In particular, the latter field broadens the classical modeling problem via the introduction of concepts like product family and product line. Until today the literature dedicated to classical product engineering has focused on the study of the so-called engineering features, e.g. form or functional features, and has ignored the larger class of features used in techniques related to the analysis and design of products with variants. This work intends to overcome this deficit by providing a broader vision of the problem and by pointing out the need for a renewed analysis and classification of feature definitions based on their originating design context. The work is part of a research project which aims to provide a conceptual framework to unify multiple feature notions and develop feature-based methodologies and applications to support product design. Abstract The paper contributes to the study of feature concept by analyzing its use in techniques and models of both classical product engineering and product engineering with variants. In particular, the latter field broadens the classical modeling problem via the introduction of concepts like product family and product line. Until today the literature dedicated to classical product engineering has focused on the study of the so-called engineering features, e.g. form or functional features, and has ignored the larger class of features used in techniques related to the analysis and design of products with variants. This work intends to overcome this deficit by providing a broader vision of the problem and by pointing out the need for a renewed analysis and classification of feature definitions based on their originating design context. The work is part of a research project which aims to provide a conceptual framework to unify multiple feature notions and develop feature-based methodologies and applications to support product design.

Published
2019

33. Inpatient trunk exercises after recent stroke: An update meta-analysis of randomized controlled trials

Author

Nildo Manoel da Silva Ribeiro, Matheus de Sales Santos, Daniele Costa Borges Souza, Igor Lima Maldonado, LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, 030506 rehabilitation, medicine.medical_specialty, Stroke patient, Physical Therapy, Sports Therapy and Rehabilitation, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Activities of Daily Living, Humans, Medicine, Postural Balance, Stroke, Randomized Controlled Trials as Topic, business.industry, Body Weight, Rehabilitation, Stroke Rehabilitation, Torso, medicine.disease, Trunk, Exercise Therapy, 3. Good health, Hospitalization, Clinical trial, Meta-analysis, Berg Balance Scale, Physical therapy, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), 0305 other medical science, business, 030217 neurology & neurosurgery, Inpatient rehabilitation
Abstract

INTRODUCTION Although the role of trunk exercises in the chronic phase of stroke is acknowledged, the addition of specific inpatient training in the subacute stage is a matter of debate and varies among centers. Recent new evidence suggests the question should be revisited. OBJECTIVE To assess the impact of the addition of specific trunk training to inpatient rehabilitation protocols after a recent stroke. METHODS A systematic review was performed assessing the impact of inpatient trunk training. The search was performed in LILACS, SciELO, PEDro, Cochrane, and NCBI PubMed databases for clinical trials published up to December 31st, 2017. The initial bibliographic research identified 3202 articles. After analyzing the titles, 19 abstracts were selected for detailed analysis. After application of the eligibility criteria, the final selection included nine studies. Outcome measurements from the same evaluation instruments were submitted to a meta-analysis to improve homogeneity (7 studies). RESULTS All patients in the included studies were recruited less than three months after a stroke. Seven studies assessed trunk control using the Trunk Impairment Scale (TIS). There was a significant improvement in trunk control with a pooled increase in TIS score of 3.3 points from the baseline (CI95:2.54-4.06, p

Published
2019
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34. Hookworm exposure decreases human papillomavirus uptake and cervical cancer cell migration through systemic regulation of epithelial-mesenchymal transition marker expression

Author

Jacobs, Brittany-Amber, Chetty, Alisha, Horsnell, William Gordon Charles, Schäfer, Georgia, Prince, Sharon, Smith, Katherine Ann, LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Department of Human Biology, University of Cape Town, This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790, and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Ancylostomatoidea, Epithelial-Mesenchymal Transition, [SDV]Life Sciences [q-bio], Uterine Cervical Neoplasms, lcsh:Medicine, Q1, Models, Biological, Article, Antigens, CD, Cell Movement, parasitic diseases, Animals, Humans, Vimentin, lcsh:Science, Human papillomavirus 16, Gene Expression Profiling, lcsh:R, Epithelial Cells, Genitalia, Female, Cadherins, R1, Disease Models, Animal, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, lcsh:Q, HeLa Cells
Abstract

International audience; Persistent infection with human papillomavirus (HPV) is responsible for nearly all new cervical cancer cases worldwide. In low-and middle-income countries (LMIC), infection with helminths has been linked to increased HPV prevalence. As the incidence of cervical cancer rises in helminth endemic regions, it is critical to understand the interaction between exposure to helminths and the progression of cervical cancer. Here we make use of several cervical cancer cell lines to demonstrate that exposure to antigens from the hookworm N. brasiliensis significantly reduces cervical cancer cell migration and global expression of vimentin and N-cadherin. Importantly, N. brasiliensis antigen significantly reduced expression of cell-surface vimentin, while decreasing HPV type 16 (HPV16) pseudovirion internalization. In vivo infection with N. brasiliensis significantly reduced vimentin expression within the female genital tract, confirming the relevance of these in vitro findings. Together, these findings demonstrate that infection with the hookworm-like parasite N. brasiliensis can systemically alter genital tract mesenchymal markers in a way that may impair cervical cancer cell progression. These findings reveal a possible late-stage treatment for reducing cervical cancer progression using helminth antigens.

Published
2018

35. An improved pseudo-state estimator for a class of commensurate fractional order linear systems based on fractional order modulating functions

Author

Yan-Qiao Wei, Da-Yan Liu, Yiming Chen, Driss Boutat, Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA), Laboratoire pluridisciplinaire de recherche en ingénierie des systèmes, mécanique et énergétique (PRISME), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), This research was partly supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Studium, Le

Subjects
0209 industrial biotechnology, General Computer Science, 010103 numerical & computational mathematics, 02 engineering and technology, [MATH] Mathematics [math], Non-asymptotic method, Pseudo-state estimator, 01 natural sciences, Set (abstract data type), 020901 industrial engineering & automation, Fractional order modulating functions, Robustness (computer science), Applied mathematics, Fractional derivative initial values, Integration by parts, 0101 mathematics, Electrical and Electronic Engineering, Algebraic number, [MATH]Mathematics [math], Mathematics, Mechanical Engineering, Linear system, Order (ring theory), Estimator, Fractional calculus, Robust estimation, Control and Systems Engineering
Abstract

This is the accepted version of the following article: An improved pseudo-state estimator for a class of commensurate fractional order linear systems based on fractional order modulating functions, which has been published in final form at https://www.sciencedirect.com/science/article/pii/S0167691118301026; International audience; In this paper, a non-asymptotic pseudo-state estimator for a class of commensurate fractional order linear systems is designed in noisy environment. Different from existing modulating functions methods, the proposed method is based on the system model with fractional sequential derivatives by introducing fractional order modulating functions. By applying the fractional order integration by parts formula and thanks to the properties of the fractional order modulating functions, a set of fractional derivatives and fractional order initial values of the output are analogously obtained by algebraic integral formulas. Then, an explicit formula of the pseudo-state is accomplished by using the fractional sequential derivatives of the output computed based on the previous results. This formula does not contain any source of errors in continuous noise-free case, and can be used to non-asymptotically estimate the pseudo-state in discrete noisy case. The construction of the fractional order modulating functions is also shown, which is independent of the time. Finally, simulations and comparison results demonstrate the efficiency and robustness of the proposed method.

Published
2018

36. Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of Mycobacterium tuberculosis Infection

Author

Erin Logan, Angelique Kany Kany Luabeya, Humphrey Mulenga, Dunja Mrdjen, Cynthia Ontong, Adam F. Cunningham, Michele Tameris, Helen McShane, Thomas J. Scriba, William G. C. Horsnell, Mark Hatherill, University of Oxford [Oxford], University of Cape Town, LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790, University of Oxford, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, lcsh:Immunologic diseases. Allergy, Tuberculosis, [SDV]Life Sciences [q-bio], Immunology, Bacille Calmette-Guérin, Measles, QuantiFERON, Mycobacterium tuberculosis, 03 medical and health sciences, Antigen, antibody, vaccine, Immunology and Allergy, Medicine, helminth, Original Research, biology, business.industry, Mycobacterium tuberculosis infection, biology.organism_classification, medicine.disease, bacterial infections and mycoses, 3. Good health, 030104 developmental biology, biology.protein, [SDV.IMM]Life Sciences [q-bio]/Immunology, Measles vaccine, enzyme-linked immunosorbent assay, Ascaris lumbricoides, Antibody, business, lcsh:RC581-607
Abstract

Background: It is unclear whether antibodies can prevent Mycobacterium tuberculosis (Mtb) infection. In this study, we examined the relationship between total plasma IgG levels, IgG elicited by childhood vaccines and soil-transmitted helminths, and Mtb infection prevalence, defined by positive QuantiFERON (QFT) test. Methods: We studied 100 Mtb uninfected infants, aged 4–6 months. Ten infants (10%) converted to positive QFT test (QFT+) within 2 years of follow-up for Mtb infection. Antibody responses in plasma samples acquired at baseline and tuberculosis investigation were analyzed by enzyme-linked immunosorbent assay and ImmunoCAP® assay. Results: QFT− infants displayed a significant increase in total IgG titers when re-tested, compared to IgG titers at baseline, which was not observed in QFT+ infants. Bacille Calmette-Guérin (BCG) vaccine-specific IgG2 and live-attenuated measles vaccine-specific IgG were raised in QFT− infants, and infants who acquired an Mtb infection did not appear to launch a BCG-specific IgG2 response. IgG titers against the endemic helminth Ascaris lumbricoides increased from baseline to QFT re-testing in all infants. Conclusion: These data show raised IgG associates with a QFT-status. Importantly, this effect was also associated with a trend showing raised IgG titers to BCG and measles vaccine. Our data suggest a possible protective association between raised antibody titers and acquisition of Mtb infection, potentially mediated by exposure to antigens both related and unrelated to Mtb.

Published
2018

37. SOLUTION OF LINEAR FRACTIONAL PARTIAL DIFFERENTIAL EQUATIONS BASED ON THE OPERATOR MATRIX OF FRACTIONAL BERNSTEIN POLYNOMIALS AND ERROR CORRECTION

Author

Li, Wenhui, Bai, Ling, Chen, Yiming, Santos, Serge, Li, Baofeng, Laboratoire pluridisciplinaire de recherche en ingénierie des systèmes, mécanique et énergétique (PRISME), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), This research was partly supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Studium, Le

Subjects
Fractional Bernstein polynomials, Convergence analysis, Operator matrix, Linear fractional partial differential equation, [MATH] Mathematics [math], Error correction, [MATH]Mathematics [math]
Abstract

This is the final version of the following article: "Dynamic Analysis of the Viscoelastic Pipeline Conveying Fluid with an Improved Variable Fractional Order Model Based on Shifted Legendre Polynomials", which has been published in final form at https://www.mdpi.com/2504-3110/3/4/52; International audience; In this paper, firstly, a new method which makes a modification of the Bern-stein polynomials is introduced to solve the linear fractional partial differential equations (FPDEs). The biggest advantage of the fractional Bernstein polynomials is that the order can be changed with the order of the fractional partial differential equations. For the first time, we try to use this method to solve the linear fractional partial differential equations. Secondly, convergence analysis and error correction are also given to make the calculation results more accurate. The concrete content of this method and error correction are explained briefly and numerical examples are given to demonstrate the validity and accuracy of the method. 1. Introduction. Since 1974, Oldam and Spanier published the first book on the theory of fractional order calculus book [1], and the fractional order calculus is developed quickly. At present, the main definitions of fractional operator include Riemann-Liouvile, Caputo, Grunwald-Letnikov, Weyl, Erdelyi-Kober, Riesz and Marchaud-Hadamard [2, 3]. With the efforts of many scholars, fractional order calculus theory to a certain extent was established. Modeling problem in the field of engineering as well as the complex mechanics, physics problems promoted fractional order calculus theory and application

Published
2018

38. CHARACTERIZING ALTERATIONS IN THE SECONDARY STRUCTURE OF TYPICAL PROTEINS UNDER EXPOSURE TO ELECTROMAGNETIC FIELDS

Author

Calabrò, Emanuele, Magazù, Salvatore, Physical Sciences and Earth Sciences of Messina University [Messina, Italy], Interuniversity Consortium of Applied Physical Sciences [Messina, Italy] (CISFA), Industrial Technical Institute 'Verona Trento-Majorana-Marconi [Messina, Italy], Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Interfaces, Confinement, Matériaux et Nanostructures ( ICMN), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), INDAM Unit [Roma], Università degli Studi di Brescia [Brescia], This research was partly supported by LE STUDIUM - Institute for Advanced Studies, Loire Valley, Orléans, France, Studium, Le, Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Brescia = University of Brescia (UniBs)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences
Abstract

This is the post-print version of the following article: "Characterizing Alterations in the Secondary Structure of Typical Proteins under Exposure to Electromagnetic Fields", which has been published in final form at https://novapublishers.com/shop/advances-in-chemistry-research-volume-42/; International audience; Over the past decades, the growing demand for electric power, electronic devices and radio frequency patterns has induced human beings to use low- and high-frequency electromagnetic fields. Nevertheless, previous research has shown that exposure to electromagnetic fields can induce health effects in living organisms. In particular, several epidemiological studies have reported a correlation between an increased risk of cancer and exposure to extremely lowfrequency electromagnetic fields. Also, in vitro tests have demonstrated that radio frequencies and microwaves emitted by mobile phones and other electronic devices can be carcinogenic and cause DNA damage and chromosome aberrations. In order to investigate accurately the alterations in living things induced by electromagnetic fields, the effects of exposure of typical proteins to low-frequency electromagnetic fields and to microwaves have been studied. Indeed, proteins are fundamental in the organic metabolism of living creatures and it has been clearly demonstrated that several types of environmental stress agents can alter the secondary structure of proteins. To this aim, Fourier Transform Infrared (FTIR) Spectroscopy was used to investigate the structure of proteins in a water solution, because it may be considered the most versatile spectroscopic technique for analyzing the secondary structure of a protein in various physiochemical environments. In fact, infrared spectroscopy detects transitions between rotational and vibration energy levels, yielding much more information on molecular structure, in particular on proteins. FTIR spectroscopy analysis showed that exposure to electromagnetic fields at intensities below the levels recommended by the International Commission on Non-Ionizing Radiation Protection, alters the secondary structure of typical proteins such as hemoglobin, myoglobin, bovine serum albumin and lysozyme. In particular, it was shown that exposure to electromagnetic fields induces the unfolding of proteins represented by transitions from the α-helix to the β-sheet structure, which may be responsible for the aggregation phenomena. Protein aggregation can lead to neurotoxic and neurodegenerative disorders that are the precursors of some pathologies.

Published
2018

39. Model-free fractional order differentiator based on fractional order Jacobi orthonormal functions

Author

Driss Boutat, Xiao-Lin Li, Yan-Qiao Wei, Yiming Chen, Da-Yan Liu, Laboratoire pluridisciplinaire de recherche en ingénierie des systèmes, mécanique et énergétique (PRISME), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA), This research was partly supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Studium, Le

Subjects
0209 industrial biotechnology, 02 engineering and technology, Differentiator, 020901 industrial engineering & automation, Fractional programming, Artificial Intelligence, Error analysis, Robustness (computer science), 0202 electrical engineering, electronic engineering, information engineering, Orthonormal basis, Electrical and Electronic Engineering, Algebraic number, Mathematics, Applied Mathematics, Mathematical analysis, 020206 networking & telecommunications, [MATH.MATH-NA] Mathematics [math]/Numerical Analysis [math.NA], Fractional calculus, Computational Theory and Mathematics, Signal Processing, Computer Vision and Pattern Recognition, Statistics, Probability and Uncertainty, Fractional order Jacobi orthonormal functions, Series expansion, Fractional order differentiator, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract

This is the accepted version of the following article: "Model-free fractional order differentiator based on fractional order Jacobi orthonormal functions", which has been published in final form at https://www.sciencedirect.com/science/article/pii/S1051200417301963; International audience; The aim of this paper is to design an algebraic and robust fractional order differentiator to estimate both the Riemann-Liouville and the Caputo fractional derivatives with an arbitrary order of an unknown signal in noisy environment, without knowing the model defining the signal. For this purpose, a new class of fractional order Jacobi orthonormal functions is firstly introduced. Secondly, the truncated fractional order Jacobi orthonormal series expansion is applied to filter the noisy signal, whose fractional derivative is used to estimate the desired one. Thus, the obtained differentiator is exactly given by an integral formula which depends on a set of design parameters. Thirdly, by applying the generalized Taylor's formula, some error analysis is provided. In particular, error bounds are given, which permit to study the design parameters' influence. Fourthly, a digital fractional order differentiator is deduced in discrete noisy case. Finally, by comparing with two existing fractional order differentiators, numerical results are given to illustrate the accuracy and the robustness of the proposed fractional order differentiator.

Published
2017

40. On the Computational Complexity of the Freezing Non-strict Majority Automata

Author

Diego Maldonado, Pedro Montealegre, Eric Goles, Nicolas Ollinger, Universidad Adolfo Ibáñez [Santiago], Univ Orleans, CNRS FRE3520, Ctr Rech Mat Div, F-45071 Orleans 2, France, LE STUDIUM (LE STUDIUM), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Laboratoire d'Informatique Fondamentale d'Orléans (LIFO), Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université d'Orléans (UO), Alberto Dennunzio, Enrico Formenti, Luca Manzoni, Antonio E. Porreca, TC 1, WG 1.5, Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Ifip, Hal

Subjects
Majority rule, Computational complexity theory, [INFO] Computer Science [cs], Decision problem, 01 natural sciences, 010305 fluids & plasmas, Automaton, Combinatorics, Von Neumann neighborhood, Lattice (order), 0103 physical sciences, [INFO]Computer Science [cs], 010306 general physics, Mathematics
Abstract

Part 2: Regular Papers; International audience; Consider a two dimensional lattice with the von Neumann neighborhood such that each site has a value belonging to $\{0,1\}$ which changes state following a freezing non-strict majority rule, i.e., sites at state 1 remain unchanged and those at 0 change iff two or more of it neighbors are at state 1. We study the complexity of the decision problem consisting in to decide whether an arbitrary site initially in state 0 will change to state 1. We show that the problem in the class $\mathbf{NC}$ proving a characterization of the maximal sets of stable sites as the tri-connected components.

Published
2017

41. Near-infrared emitting probes for biological imaging: Organic fluorophores, quantum dots, fluorescent proteins, lanthanide(III) complexes and nanomaterials

Author

Stéphane Petoud, Svetlana V. Eliseeva, Ivana Martinić, Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), and Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)

Subjects
Lanthanide, Materials science, [SDV]Life Sciences [q-bio], Biophysics, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Nanomaterials, [CHIM]Chemical Sciences, business.industry, Near-infrared spectroscopy, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Photobleaching, Fluorescence, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Autofluorescence, Quantum dot, Optoelectronics, 0210 nano-technology, business, Biological imaging
Abstract

International audience; Fluorescence optical imaging is a highly sensitive and powerful tool with diverse in vitro and in vivo applications for preclinical and clinical studies. This review is focused on the optical imaging in the near-infrared (NIR) region since improved signal-to-noise ratio and deeper penetration of light through tissues could be achieved due to the minimal autofluorescence and reduced light scattering at these wavelengths. In particular, imaging agents absorbing and emitting in the biological diagnostic window (650–1450 nm) are discussed. The photophysical properties and particularities of chemical structures or compositions of four different families of probes : (i) organic fluorophores, (ii) fluorescent proteins (FPs), (iii) semi-conductor nanocrystals (quantum dots) and (iv) lanthanide(III)-based complexes and nanomaterials are presented. Advantages and drawbacks, commercial availability and toxicity as well as selected applications of these probes are discussed. A specific attention is given to lanthanide(III)-based compounds due to their unique optical properties, e.g. sharp emission bands with minimal sensitivity to the microenvironment, large differences between excitation and emission wavelengths and strong resistance toward photobleaching. The use of such probes brings additional perspectives and facilitates developments of novel strategies in optical imaging including real-time experiments and new approaches for diagnostic.

Published
2017

42. Dynamic Analysis of the Viscoelastic Pipeline Conveying Fluid with an Improved Variable Fractional Order Model Based on Shifted Legendre Polynomials

Author

Yuanhui Wang, Yiming Chen, LE STUDIUM (LE STUDIUM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Laboratoire pluridisciplinaire de recherche en ingénierie des systèmes, mécanique et énergétique (PRISME), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), This research was partly supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France, and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Statistics and Probability, lcsh:Analysis, lcsh:Thermodynamics, variable fractional order equation, 01 natural sciences, Viscoelasticity, 010305 fluids & plasmas, Dynamic problem, lcsh:QC310.15-319, 0103 physical sciences, Applied mathematics, [MATH]Mathematics [math], 0101 mathematics, Legendre polynomials, dynamic response, Variable (mathematics), Mathematics, numerical solution, improved model, lcsh:Mathematics, Numerical analysis, lcsh:QA299.6-433, Statistical and Nonlinear Physics, lcsh:QA1-939, shifted legendre polynomial, 010101 applied mathematics, Nonlinear system, Piecewise, viscoelastic pipeline conveying fluid, Displacement (fluid), Analysis
Abstract

This is the final version of the following article: "Dynamic Analysis of the Viscoelastic Pipeline Conveying Fluid with an Improved Variable Fractional Order Model Based on Shifted Legendre Polynomials", which has been published in final form at https://www.mdpi.com/2504-3110/3/4/52; International audience; Viscoelastic pipeline conveying fluid is analyzed with an improved variable fractional order model for researching its dynamic properties accurately in this study. After introducing the improved model, an involuted variable fractional order, which is an unknown piecewise nonlinear function for analytical solution, an equation is established as the governing equation for the dynamic displacement of the viscoelastic pipeline. In order to solve this class of equations, a numerical method based on shifted Legendre polynomials is presented for the first time. The method is effective and accurate after the numerical example verifying. Numerical results show that how dynamic properties are influenced by internal fluid velocity, force excitation, and variable fractional order through the proposed method. More importantly, the numerical method has shown great potentials for dynamic problems with the high precision model.

Published
2019

43. Taming Lanthanide-Centered Upconversion at the Molecular Level

Author

Claude Piguet, Laure Guénée, Davood Zare, Svetlana V. Eliseeva, Bahman Golesorkhi, Andreas Hauser, Stéphane Petoud, Homayoun Nozary, Yan Suffren, Department of Physical Chemistry, University of Geneva, Université de Genève = University of Geneva (UNIGE), Laboratory of X-ray Crystallography, Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Service de Pédiatrie médicale - Spécialités médicales [CHU Limoges], CHU Limoges, University of Geneva [Switzerland], Department of Inorganic, Analytical and Applied Chemistry - University of Geneva, Department of Inorganic and Analytical Chemistry - University of Geneva, Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
Lanthanide, Photon, 010405 organic chemistry, Chemistry, Doping, Intermetallic, Nanotechnology, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, 01 natural sciences, Photon upconversion, 0104 chemical sciences, Inorganic Chemistry, Chemical physics, Excited state, Intramolecular force, ddc:540, Physical and Theoretical Chemistry, Absorption (electromagnetic radiation), ComputingMilieux_MISCELLANEOUS
Abstract

Considered at the beginning of the 21th century as being incompatible with the presence of closely bound high-energy oscillators, lanthanide-centered superexcitation, which is the raising of an already excited electron to an even higher level by excited-state energy absorption, is therefore a very active topic strictly limited to the statistical doping of low-phonon bulk solids and nanoparticles. We show here that molecular lanthanide-containing coordination complexes may be judiciously tuned to overcome these limitations and to induce near-infrared (NIR)-to-visible (VIS)-light upconversion via the successive absorption of two low-energy photons using linear-optical responses. Whereas single-ion-centered excited-state absorption mechanisms remain difficult to implement in lanthanide complexes, the skillful design of intramolecular intermetallic energy-transfer processes operating in multimetallic architectures is at the origin of the recent programming of erbium-centered molecular upconversion.

Published
2016

44. Carleman estimates for elliptic operators with complex coefficients. Part I: boundary value problems

Author

Jérôme Le Rousseau, Mourad Bellassoued, Faculté des Sciences de Bizerte, Département de Mathematiques, Université de Carthage - University of Carthage, Fédération de recherche Denis Poisson (FDP), Université d'Orléans (UO)-Université de Tours-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Mathématiques - Analyse, Probabilités, Modélisation - Orléans (MAPMO), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Faculté des Sciences de Bizerte [Université de Carthage], Université d'Orléans (UO)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), and Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)

Subjects
Lopatinskii conditions, elliptic operators, Applied Mathematics, General Mathematics, Mathematical analysis, Boundary problem, Boundary (topology), Carleman estimate, Elliptic operator, Operator (computer programming), Factorization, boundary problem, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Boundary value problem, Connection (algebraic framework), AMS 2000 subject classification: 35B45, 35J30, 35J40, Sign (mathematics), Mathematics
Abstract

International audience; We consider elliptic operators with complex coefficients and we derive microlocal and local Carleman estimates near a boundary, under sub-ellipticity and strong Lopatinskii conditions. Carleman estimates are weighted {\em a priori} estimates for the solutions of the associated elliptic boundary problem. The weight is of exponential form, $\exp(\tau \varphi)$, where $\tau>0$ is meant to be taken as large as desired. Such estimates have numerous applications in unique continuation, inverse problems, and control theory. Based on inequalities for interior and boundary differential quadratic forms, the proof relies on the microlocal factorization of the symbol of the conjugated operator in connection with the sign of the imaginary part of its roots. We further consider weight functions of the form $\varphi= \exp(\gamma \psi)$, with $\gamma>0$ meant to be taken as large as desired, and we derive Carleman estimates where the dependency upon the two large parameters, $\tau$ and $\lambda$, is made explicit. Applications on unique continuation properties are given.

Published
2015

45. The Journal of Space Weather and Space Climate – the first six years: status and evaluation of published papers and policies

Author

Jan Janssens, Agnès Henri, Jurgen Watermann, Anna Belehaki, Jean Lilensten, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), National Observatory of Athens (NOA), LE STUDIUM (LE STUDIUM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Solar-Terrestrial Centre of Excellence [Brussels] (STCE), EDP SCiences, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Sciences, EDP

Subjects
Atmospheric Science, 010504 meteorology & atmospheric sciences, Meteorology, Computer science, lcsh:QC851-999, Space weather, Space (commercial competition), 01 natural sciences, Physics::Geophysics, Space and Planetary Science, Physics::Space Physics, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, lcsh:Meteorology. Climatology, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Physics::Atmospheric and Oceanic Physics, 0105 earth and related environmental sciences
Abstract

International audience; No abstract available

Published
2017

46. Highly emitting near-infrared lanthanide 'encapsulated sandwich' metallacrown complexes with excitation shifted toward lower energy

Author

Stéphane Petoud, Vincent L. Pecoraro, Marilyn M. Olmstead, Joseph Jankolovits, Svetlana V. Eliseeva, Evan R. Trivedi, Department of Chemistry, University of Michigan, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, LE STUDIUM (LE STUDIUM), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of chemistry - University of California, University of California [Davis] (UC Davis), University of California-University of California, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of California (UC)-University of California (UC), European Project: 611488,EC:FP7:PEOPLE,FP7-PEOPLE-2013-IRSES,METALLACROWNS(2013), and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
Models, Molecular, Lanthanide, Infrared Rays, [SDV]Life Sciences [q-bio], Inorganic chemistry, Bioengineering, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, Biochemistry, Lanthanoid Series Elements, Article, Catalysis, Colloid and Surface Chemistry, Models, Organometallic Compounds, Nanotechnology, Molecule, Absorption (electromagnetic radiation), Metallacrown, Group 2 organometallic chemistry, Crystallography, Molecular Structure, 010405 organic chemistry, Ligand, Chemistry, Molecular, General Chemistry, Chromophore, 0104 chemical sciences, Zinc, Chemical Sciences, X-Ray, Physical chemistry, Quantum Theory, Luminescence
Abstract

International audience; Near-infrared (NIR) luminescent lanthanide complexes hold great promise for practical applications, as their optical properties have several complementary advantages over organic fluorophores and semiconductor nanoparticles. The fundamental challenge for lanthanide luminescence is their sensitization through suitable chromophores. The use of the metallacrown (MC) motif is an innovative strategy to arrange several organic sensitizers at a well-controlled distance from a lanthanide cation. Herein we report a series of lanthanide “encapsulated sandwich” MC complexes of the form Ln$^{3+}$[12-MC$_{Zn(II),quinHA}$-4}]$_2$[24-MC$_{Zn(II),quinHA}$$^{-8}$] (Ln$^{3+}$[$Zn(II)MC_{quinHA}$]) in which the MC framework is formed by the self-assembly of Zn$^{2+}$ ions and tetradentate chromophoric ligands based on quinaldichydroxamic acid (quinHA). A first-generation of luminescent MCs was presented previously but was limited due to excitation wavelengths in the UV. We report here that through the design of the chromophore of the MC assembly, we have significantly shifted the absorption wavelength toward lower energy (450 nm). In addition to this near-visible inter- and/or intraligand charge transfer absorption, Ln$^{3+}$[Zn(II)MC$_{quinHA}$] exhibits remarkably high quantum yields, long luminescence lifetimes (CD$_3$OD; Yb$^{3+}$, QLn$^L$ = 2.88(2)%, $\tau _{obs}$ = 150.7(2) $\mu$s; Nd$^{3+}$, QLn$^L$ = 1.35(1)%, $\tau _{obs}$ = 4.11(3) $\mu$s; Er$^{3+}$, QLn$^L$ = 3.60(6)·10$^{-2}$%, $\tau _{obs}$ = 11.40(3) $\mu$s), and excellent photostability. Quantum yields of Nd$^{3+}$ and Er$^{3+}$ MCs in the solid state and in deuterated solvents, upon excitation at low energy, are the highest values among NIR-emitting lanthanide complexes containing C–H bonds. The versatility of the MC strategy allows modifications in the excitation wavelength and absorptivity through the appropriate design of the ligand sensitizer, providing a highly efficient platform with tunable properties.

Published
2014

47. Lanthanide-to-Lanthanide Energy-Transfer Processes Operating in Discrete Polynuclear Complexes: Can Trivalent Europium Be Used as a Local Structural Probe?

Author

Stéphane Petoud, Claude Piguet, Laure Guénée, Amir Hossein Zaim, Homayoun Nozary, Svetlana V. Eliseeva, Department of Inorganic and Analytical Chemistry - University of Geneva, Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), LE STUDIUM (LE STUDIUM), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Laboratory of X-ray Crystallography, University of Geneva [Switzerland], Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université de Genève = University of Geneva (UNIGE), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Frapart, Isabelle

Subjects
Lanthanide, Structural probes, [SDV]Life Sciences [q-bio], Inorganic chemistry, Intermetallic, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Lanthanoid Series Elements, Catalysis, symbols.namesake, Europium, Lanthanides, Fermi's golden rule, lanthanides, Emission spectrum, photophysics, Polynuclear complexes, polynuclear complexes, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, structural probes, General Chemistry, Acceptor, 0104 chemical sciences, [SDV] Life Sciences [q-bio], Photophysics, Energy Transfer, Energy transfer, Intramolecular force, ddc:540, symbols, Physical chemistry, Excitation
Abstract

International audience; This work, based on the synthesis and analysis of chemical compounds, describes a kinetic approach for identifying intramolecular intermetallic energy-transfer processes operating in discrete polynuclear lanthanide complexes, with a special emphasis on europium-containing entities. When all coordination sites are identical in a (supra)molecular complex, only heterometallic communications are experimentally accessible and a Tb → Eu energy transfer could be evidenced in [TbEu(L5)(hfac)6] (hfac = hexafluoroacetylacetonate), in which the intermetallic separation amounts to 12.6 Å. In the presence of different coordination sites, as found in the trinuclear complex [Eu3(L2)(hfac)9], homometallic communication can be induced by selective laser excitation and monitored with the help of high-resolution emission spectroscopy. The narrow and non-degenerated character of the Eu((5)D0 ↔ (7)F0) transition excludes significant spectral overlap between donor and acceptor europium cations. Intramolecular energy-transfer processes in discrete polynuclear europium complexes are therefore limited to short distances, in agreement with the Fermi golden rule and with the kinetic data collected for [Eu3(L2)(hfac)9] in the solid state and in solution. Consequently, trivalent europium can be considered as a valuable local structural probe in discrete polynuclear complexes displaying intermetallic separation in the sub-nanometric domain, a useful property for probing lanthanido-polymers.

Published
2014

48. Monetary Regimes and EU Accession: Comparing Bulgaria and Romania

Author

Nenovsky, Nikolay, Tochkov, Kiril, Turcu, Camélia, LE STUDIUM (LE STUDIUM), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Laboratoire d'économie d'Orleans (LEO), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Texas Christian University (TCU), University of Texas Christian, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and Laboratoire d'économie d'Orleans [2008-2011] (LEO)

Subjects
Monetary regimes, Interwar monetary history, Moral hazard, Post-communist transition, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, EU accession
Abstract

International audience; This paper traces the origins of the different monetary regimes adopted in Bulgaria and Romania in 1996-97 and examines their performance during the EU accession. The findings indicate that the constraints of the currency board in Bulgaria shifted economic activity towards the private sector, while the discretionary policies in Romania turned public finances into both a contributor and a response mechanism to economic imbalances. While the prospects of EU accession initially enhanced the performance of the monetary anchors, the implicit insurance of EU membership increased moral hazard and led to a rapid rise in private and public debt. The paper also explores the historical parallels between the monetary regimes of Bulgaria and Romania in 1996-97 and 1925-1940.

Published
2013

49. Cement CO2-alteration propagation at the well-caprock-reservoir interface and influence of diffusion

Author

Anne-Gaëlle Bader, Antonin Fabbri, Philippe Blanc, Fabrizio Gherardi, Frédéric Wertz, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), LE STUDIUM (LE STUDIUM), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), École Nationale des Travaux Publics de l'État (ENTPE), Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement-École Nationale des Travaux Publics de l'État (ENTPE), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS), and École Nationale des Travaux Publics de l'État (ENTPE)-Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement

Subjects
Cement, Calcite, Materials science, Mineralogy, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, 010501 environmental sciences, Management, Monitoring, Policy and Law, engineering.material, 010502 geochemistry & geophysics, 01 natural sciences, Pollution, Petroleum reservoir, Industrial and Manufacturing Engineering, Portlandite, Supercritical fluid, chemistry.chemical_compound, General Energy, Brine, chemistry, Caprock, engineering, Porosity, 0105 earth and related environmental sciences
Abstract

International audience; A geochemical model of wellbore cement-caprock-reservoir interfaces is developed. The model predicts the mechanisms of chemical alteration of cement due to interaction with the acid brine obtained after the injection of supercritical CO2 into the reservoir rock. Numerical outputs indicate that, at the well-reservoir interface, intrusion into the cement phase of acid brine accompanied by aqueous CO2 quasi-instantaneously transforms Portlandite and CSH into Calcite and hydrated Si-gel, leading to a slight but moderate porosity decrease, from 28% to similar to 20%. Conversely, at the well-caprock interface, Portlandite first leaches and the Ca2+ ions released from it migrate towards the caprock, where they eventually combine with slowly diffusing aqueous CO2 to form Calcite, up to the porosity collapse of the interface. This can significantly affect the sealing behaviour of the geological storage. We can finally deduce a time-space characterisation of the system enhancing the main chemical mechanisms in view of a future export to a geomechanical model. (C) 2012 Elsevier Ltd. All rights reserved.

Published
2013

50. Modeling geochemical reactions in wellbore cement: assessing preinjection integrity in a site for CO2 geological storage

Author

Gherardi, Fabrizio, Audigane, Pascal, LE STUDIUM (LE STUDIUM), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Institut National de la Recherche Agronomique (INRA)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), and Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut National de la Recherche Agronomique (INRA)-Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de recherche pour le développement [IRD] : UR-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, [SDE.MCG]Environmental Sciences/Global Changes
Abstract

International audience; We present numerical simulations of isothermal reactive flow which might be induced by fluid migration at the caprock-cement interface of an idealized abandoned well in an area considered for geological sequestration of CO2 in the Paris Basin, France. The calculations are aimed at identifying the mineralogical transformations likely occurring in the cement during the working life and after the closure of the wells present in the area, before the injection of CO2. Field evidence, experimental data, and previous numerical simulations have been used to constrain the initial geochemical conditions and the hydraulic parameters of the model. Significant mineralogical transformations in the cement (portlandite and katoite dissolution, CSH, ettringite, hydrotalcite precipitation), and minor modifications of the initial clayrock mineralogical assemblage (quartz, montmorillonite and illite dissolution, and precipitation of cement-like phases) are predicted at the caprock-cement interface. Associated with these mineralogical transformations, measurable variations in porosity are also computed. Although Portland cement is predicted to retain its integrity at some distance from the interface, calculations confirm the general view that material alteration at the interfaces is of major concern for the minimization of the risks of CO2 leakage from storage zones. Numerical outputs are sensitive with respect to poorly constrained physical and transport parameters, such as the spatial distribution of interconnected porosity in the cement. Different degrees of portlandite dissolution/carbonate precipitation can be predicted during in situ ageing under conditions similar to the Paris Basin, depending on the adopted gridding scheme, i.e. on the conceptualization of the cement as a homogeneous or dual-porosity medium.

Published
2013

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