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Objective: This study aimed to investigate the effects of drying methods on passion fruit peels. Methods: Passion fruit peels were treated with microwave vacuum freeze-drying, vacuum freeze-drying, heat pump drying, and far-infrared radiation drying. The drying characteristics, rehydration ratio, color difference, dietary fiber, functional properties, microstructure, total phenolic content, total flavonoid content, and antioxidant properties were measured and determined respectively. Results: Heat pump-dried passion fruit peels had poor rehydration ratio and functional properties. Microwave vacuum freeze drying reduced the drying time by 53% when compared tp far-infrared radiation drying, and the microwave vacuum freeze-dried treated passion fruit peels had a higher rehydration ratio (7.45), total phenolic content (13.45 mg GAE/g DW) and antioxidant activity (DPPH was 38.53%, FRAP was 1.14 mmol/L). Additionally, the passion fruit peels were vacuum freeze-dried with treatment to increase their water holding capacity [(21.64±0.21) g/g], oil holding capacity [(6.09±0.71) g/g], swelling [(25.00±1.00) g/g], and total flavonoid content (7.84 mg RT/g DW). Different drying techniques led to higher rehydration ratios, and they also significantly differed (P＜0.05) in terms of dietary fiber, functional properties, total phenolic content, total flavonoid content and antioxidant activity of the peels. Conclusion: The quality of passion fruit peel can be greatly affected by the drying process, and microwave vacuum freeze-drying is the most preferred technique.

Objective The aim of this study is to explore the accuracy of using gastrointestinal decompression method to determine the tip position of the triple-lumen nasointestinal tube in critically ill patients. Methods A retrospective analysis was conducted on the medical records of 120 critically ill patients with indwelling triple-lumen nasointestinal tubes from June 2020 to April 2022. All patients underwent blind insertion of a triple-lumen nasointestinal tube. The patients were divided into an experimental group and a control group, where the experimental group used a gastrointestinal decompression device to connect the suction cavity with the opening in the stomach, and combined with auscultation and liquid reflux to measure pH value to determine whether the tip of the catheter passed through the pylorus; The control group only used auscultation and pH measurement with liquid reflux to determine whether the catheter position passed through the pylorus. Bedside X-ray was used to confirm the accurate position of the catheter tip. Results Among the 65 cases in the experimental group, 59 cases were successfully catheterized and 6 cases failed by the initial judgment, consistent with the results of bedside X-ray. Among the 55 cases in the control group, 46 cases were catheterized and 9 cases failed by the initial judgment, but only 39 cases were successful and 16 cases failed by the judgment of X-ray. There was a significant difference in the accuracy of catheterization between the two groups (χ2=8. 785, P=0. 003). Conclusion Gastrointestinal decompression method can quickly and accurately determine the tip position of the nasointestinal tube, which is of great help for clinical work. (目的 探讨运用胃肠减压法判断危重症患者三腔鼻肠管位置的准确性。方法 回顾性分析2020年6月—2022年4月120例留置三腔鼻肠管的危重症患者的病历资料。所有患者均为盲插法留置的三腔鼻肠管。根据鼻肠管导管尖端位置判断方法不同将患者分为研究组和对照组, 其中研究组采用胃肠减压装置连接开口在胃内的吸引腔, 并结合听诊和回抽液体测pH值的方法判断导管尖端是否通过幽门; 对照组仅使用听诊和回抽液体测pH值的方法判定导管位置是否通过幽门。床旁X线被用来证实导管尖端的准确位置。结果 研究组65例患者中, 初步判断59例置管成功, 6例失败, 与床旁X线的结果一致; 对照组55例患者中, 初步判断46例置管成功, 9例失败, 实际成功39例, 失败16例。两组置管准确率差异有统计学意义(χ2=8. 785, P=0. 003)。结论 胃肠减压法能够快速、准确地判断鼻肠管位置, 对临床工作具有重要帮助。)

Objective To develop a self-made questionnaire on the content quality and clinical applicability of Traditional Chinese Medicine (TCM) nursing program. The content, quality and clinical applicability of TCM nursing plan in acute and convalescent stage of stroke were evaluated by clinical nurses through questionnaire. Methods The questionnaire was designed with reference to the questionnaire on the applicability of clinical diagnosis and treatment guidelines of TCM, and the content validity was evaluated by expert consultation. Totally 49 nurses from 9 hospitals were selected for questionnaire survey, and the questionnaire results were processed and analyzed by SPSS 20. 0 software. Results The content validity S-CVI/Ave score of the self-designed questionnaire was 0. 94; The results of the questionnaire showed that the overall content of the approval scheme was "better than the original nursing routine" (59. 18%); The recognition of "common symptoms" (36. 70%) and "syndrome classification" (36. 70%) was the lowest. Conclusion In the future, efforts should be made to widely collect the clinical user experience and suggestions of TCM nursing scheme, and further improve the scheme content in combination with the evidence-based concept to make it closer to the clinical practice. (目的 自制中医护理方案的内容质量和临床适用性问卷。并通过问卷调查临床护士对中风急性期与恢复期中医护理方案的质量和临床适用性的评价。方法 参考中医临床诊疗指南适用性调查问卷自行设计调查问卷, 应用专家咨询法进行内容效度评价。选取9所医院的49名护士进行问卷调查, 对问卷结果应用SPSS20. 0软件进行处理分析。结果 自设问卷的内容效度S-CVI/Ave得分为0. 94; 问卷结果显示: 认可方案整体内容“优于本单位原有护理常规”(59. 18%)的人数最多; 对方案中“常见症状”(36. 70%)与 “证候分类”(36. 70%)的认可度最低。结论 未来需要广泛收集中医护理方案临床使用者体验及建议, 并结合循证理念进一步完善方案内容, 使其更贴近临床实际。)

Colchicine is an alkaloid derived from Colchicum automnale and Gloriosa superba, which becomes more widely used for the treatment of acute gouty arthritis, but its therapy dose is near to the poisoning dose. This paper reported two cases of colchicine overdose with different prognosis. Even the continuous veno-venous hemofiltration have been done to decrease the serum concentration of colchicine, the prognosis could not be reversed in case one. Due to the lower serum concentration of drug, case two had the better prognosis. The coagulopathy and elevated liver enzyme had been found in both cases. A significant leukocytosis with thrombocytopenia was observed in case one. The colchicine is a high poisonous drug, over dose of which has a bad prognosis and rapid change of clinical status. The clinical doctors should take it seriously. (秋水仙碱是从秋水仙和桂花中提取的生物碱, 广泛应用于急性痛风性关节炎, 但使用剂量接近于中毒剂量。本文报告了两例秋水仙碱中毒病例, 其中一例经连续血液滤过降低了血清秋水仙碱浓度后, 预后依然不可逆转; 第二例由于血药浓度相对较低而预后更好。两例均见凝血功能障碍和肝酶升高, 其中病例一有明显白细胞增多伴血小板减少。秋水仙碱药物不良反应明显, 服用过量者预后差且病情进展快, 临床应用需小心谨慎。)

This study aimed to explore physicians' and pharmacists' knowledge, attitudes, and practice (KAP) regarding the prevention and treatment of cardiovascular toxicity associated with cancer treatment. A multicenter cross-sectional study included physicians and pharmacists between April 2023 and June 2023. The study included 918 participants (514 physicians and 404 pharmacists). The average scores of knowledge, attitudes, and practice were 11.6 ± 3.39, 24.7 ± 2.6, and 26.3 ± 6.8 points. Sufficient knowledge was significantly associated with age ≥ 41 years (odds ratio (OR) = 2.745, 95% confidence interval (CI) 1.086–6.941, P = 0.033), male (OR = 2.745, 95% CI 1.150–2.223, P = 0.005), bachelor's degree (OR = 0.084, 95% CI 0.013–0.533, P = 0.009), master's degree and above (OR = 0.096, 95% CI 0.015–0.609, P = 0.013), physician occupation (OR = 7.601, 95% CI 1.337–43.207, P = 0.022), pharmacy department (OR = 18.858, 95% CI 3.245–109.57, P = 0.001), oncology department (OR = 4.304, 95% CI 2.426–7.634, P < 0.001), cardiology department (OR = 3.001, 95% CI 1.387–6.492, P = 0.005), hospitals located in Eastern China (OR = 1.957, 95% CI 1.120–3.418, P = 0.018), and hospitals located in Western China (OR = 3.137, 95% CI 1.783–5.518, P < 0.001). Positive attitudes were significantly associated with a senior professional title (OR = 2.989, 95% CI 1.124–7.954, P = 0.028) and hospitals located in Eastern China (OR = 0.424, 95% CI 0.257–0.698, P = 0.001), Western China (OR = 0.231, 95% CI 0.136–0.394, P < 0.001), and Southern China (OR = 0.341, 95% CI 0.198–0.587, P < 0.001). Proactive practice was significantly associated with male (OR = 1.414, 95% CI 1.029–1.943, P = 0.033), senior professional title (OR = 3.838, 95% CI 1.176–12.524, P = 0.026), oncology department (OR = 3.827, 95% CI 2.336–6.272, P < 0.001), and cardiology department (OR = 2.428, 95% CI 1.263–4.669, P = 0.008). Both physicians and pharmacists had positive attitudes toward the prevention and treatment of cardiovascular toxicity associated with cancer treatment, while their knowledge and practice were not as proactive. [ABSTRACT FROM AUTHOR]

Black carbon in snow (BCS) is a crucial parameter in Earth System modeling, as it influences global radiative balance. Here, simulated BCS from Coupled Model Intercomparison Project Phase 5 and 6 (CMIP5 and CMIP6) that provided BCS as a model output were evaluated. In comparison with global BCS observations, CMIP5/6 models successfully reproduced long‐term historical trends linked to human activities, but struggled capturing decadal variability caused by natural climate variability. CMIP6 models NorESM2‐MM, NorESM2‐LM, and TaiESM1 yielded the most accurate simulations of BCS concentration with modest overestimation of <50%, while the four CESM2 models underestimated concentrations by up to ∼80%. These errors effectively balanced for the CMIP6 multi‐model ensemble mean (MME), which had a relative error (RE) of −37%. However, the CMIP5 MME was less reliable due to extreme overestimation by up to 8,000% in the three MIROC models. The significant BCS concentration errors in the MIROC and CESM2 models were linked mainly to errors in handling of BC in snow processes. Conversely, marked improvements in NorESM, the only common to both CMIP5 and CMIP6, were due to improved simulation of black carbon deposition. BCS errors significantly impacted radiative forcing estimates, particularly at the poles, where model errors reached several thousandfold. CMIP6 exhibited superior results compared to CMIP5, achieving global MME RE of −33% in radiative forcing estimates. However, it's worth noting BCS output is currently limited, with only seven models available for each of CMIP5 and CMIP6 here. Additional models simulating BCS are desirable in the next CMIP generations. Plain Language Summary: Black carbon in snow (BCS) has important implications for snow albedo reduction, solar radiation absorption, and snow melt acceleration on the Earth. However, model performance in BCS simulation remains unclear in the widely used Coupled Model Intercomparison Project phases 5 and 6 (CMIP5/6). In this study, CMIP5 and CMIP6 models providing BCS information were evaluated against a global data set of BCS observations from ice cores and snow samples. Results indicate that both CMIP generations successfully reproduce long‐term trends in BCS but fail to capture the decadal variability. Marked differences exist in modeled BCS concentrations, with the best‐performing models (NorESM2‐LM, NorESM2‐MM, and TaiESM1) overestimating concentrations by <50%, while the three worst‐performing MIROC models yield extreme overestimation. Such discrepancies stem primarily from the post‐depositional treatment of black carbon in snow, which influences the estimation of climate‐warming effects of BCS. Key Points: The global pattern of black carbon in snow (BCS) is effectively simulated by CMIP5/6 models, but large errors remainPost‐depositional snow processes contribute most to the large simulated‐BCS errorsBCS‐induced radiative forcing in Antarctica is poorly simulated by CMIP5/6 models with an overestimation of ∼200,000% and 144%, respectively [ABSTRACT FROM AUTHOR]

Background: Injury to the spinal cord of children may cause potential brain reorganizations, affecting their rehabilitation. However, the specific functional alterations of children after complete spinal cord injury (CSCI) remain unclear. Purpose: To explore the specific functional changes in local brain and the relationship with clinical characteristics in pediatric CSCI patients, clarifying the impact of CSCI on brain function in developing children. Study Type: Prospective. Subjects: Thirty pediatric CSCI patients (7.83 ± 1.206 years) and 30 age‐, gender‐matched healthy children as controls (HCs) (8.77 ± 2.079 years). Field Strength/Sequence: 3.0 T/Resting‐state functional MRI (rs‐fMRI) using echo‐planar‐imaging (EPI) sequence. Assessment: Amplitude of low‐frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were used to characterize regional neural function. Statistical Tests: Two‐sample t‐tests were used to compare the ALFF, fALFF, ReHo values of the brain between pediatric CSCI and HCs (voxel‐level FWE correction, P < 0.05). Spearman correlation analyses were performed to analyze the associations between the ALFF, fALFF, ReHo values in altered regions and the injury duration, sensory motor scores of pediatric CSCI patients (P < 0.05). Then receiver operating characteristic (ROC) analysis was conducted to identify possible sensitive imaging indicators for clinical therapy. Results: Compared with HCs, pediatric CSCI showed significantly decreased ALFF in the right postcentral gyrus (S1), orbitofrontal cortex, and left superior temporal gyrus (STG), increased ALFF in bilateral caudate nucleus, thalamus, middle cingulate gyrus, and cerebellar lobules IV‐VI, and increased ReHo in left cerebellum Crus II and Brodmann area 21. The ALFF value in the right S1 negatively correlated with the pinprick and light touch sensory scores of pediatric CSCI. When the left STG was used as an imaging biomarker for pediatric CSCI, it achieved the highest area under the curve of 0.989. Conclusions: These findings may provide potential neural mechanisms for sensory motor and cognitive‐emotional deficits in children after CSCI. Evidence Level: 2 Technical Efficacy: Stage 5 [ABSTRACT FROM AUTHOR]

The type of matrix resin of the semi‐conductive shielding layer directly affects the thermal aging characteristics of the semi‐conductive shielding layer and the high‐voltage cable. In this paper, ethylene vinyl acetate (EVA), ethylene ethyl acrylate (EEA), and ethylene butyl acrylate (EBA) resins were used as matrix to prepare carbon black (CB) + EVA, CB + EEA, and CB + EBA shielding materials. The law of physicochemical, electrical, and mechanical properties of different matrix resin shielding materials with aging time was studied, and the influence mechanism of matrix resin on the aging characteristics of shielding materials was analyzed. The results show: with the increase of aging time, the crystallization area and the number of functional groups of the three shielding materials decreased to varying degrees. The number of functional groups in CB + EBA shielding materials decreased evenly with aging time, but that of CB + EVA and CB + EEA shielding materials changed significantly after 7 days of aging. After 60 days of aging, the crystallization area of CB + EBA shielding material changed slightly, but that of CB + EVA and CB + EEA shielding material decrease significantly. The electrical properties of the three shielding materials showed different decreasing trend with aging time. When the aging time is 7 days, the positive temperature coefficient (PTC) effect of CB + EEA shielding material decreases obviously. When the aging time is 30 days, the resistivity of CB + EVA and CB + EEA shielding material increases slowly (9 Ω cm–12 Ω cm) with the increase of temperature. When the aging time is 60 days, the resistivity of CB + EBA shielding material decreases obviously, and the PTC effect weakens obviously. Taking the mechanical properties of the shielding material as reference, the rapid deterioration stage of the mechanical properties of the three shielding materials is different. The CB + EVA and CB + EEA shielding material rapid deterioration time is 0–7 days, and the tensile strength and elongation of the shielding material are greatly reduced. The rapid deterioration stage of CB + EBA shielding material is 7–30 days, and the tensile strength and elongation decrease from 24.38 MPa and 499.5% to 14 MPa and 155.7%, respectively. This work can provide data support for the selection of matrix resin of shielding material and the fault analysis of shielding layer of high voltage cable. [ABSTRACT FROM AUTHOR]