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256 results on '"LIN, JIHONG"'

1. Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial

Author

Qin, Jianjun, Xue, Liyan, Hao, Anlin, Guo, Xiaofeng, Jiang, Tao, Ni, Yunfeng, Liu, Shuoyan, Chen, Yujie, Jiang, Hongjing, Zhang, Chen, Kang, Mingqiang, Lin, Jihong, Li, Hecheng, Li, Chengqiang, Tian, Hui, Li, Lin, Fu, Junke, Zhang, Yong, Ma, Jianqun, Wang, Xiaoyuan, Fu, Maoyong, Yang, Hao, Yang, Zhaoyang, Han, Yongtao, Chen, Longqi, Tan, Lijie, Dai, Tianyang, Liao, Yongde, Zhang, Weiguo, Li, Bin, Chen, Qixun, Guo, Shiping, Qi, Yu, Wei, Li, Li, Zhigang, Tian, Ziqiang, Kang, Xiaozheng, Zhang, Ruixiang, Li, Yong, Wang, Zhen, Chen, Xiankai, Hou, Zhiguo, Zheng, Rongrong, Zhu, Wenqing, He, Jie, and Li, Yin

Published
2024
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10. Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

Author

Hu, Jiong, Dziumbla, Sarah, Lin, Jihong, Bibli, Sofia-Iris, Zukunft, Sven, de Mos, Julian, Awwad, Khader, Frömel, Timo, Jungmann, Andreas, Devraj, Kavi, Cheng, Zhixing, Wang, Liya, Fauser, Sascha, Eberhart, Charles G, Sodhi, Akrit, Hammock, Bruce D, Liebner, Stefan, Müller, Oliver J, Glaubitz, Clemens, Hammes, Hans-Peter, Popp, Rüdiger, and Fleming, Ingrid

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Diabetes, Eye Disease and Disorders of Vision, Metabolic and endocrine, Animals, Antigens, CD, Cadherins, Capillary Permeability, Carrier Proteins, Cell Membrane, Cell Movement, Cell Survival, Diabetic Retinopathy, Disease Models, Animal, Disease Progression, Docosahexaenoic Acids, Endothelial Cells, Ependymoglial Cells, Epoxide Hydrolases, Fatty Acids, Unsaturated, Female, Humans, Intercellular Junctions, Male, Mice, Mice, Inbred C57BL, Pancreatic Elastase, Pericytes, Presenilin-1, Retina, Solubility, Vitreous Body, General Science & Technology
Abstract

Diabetic retinopathy is an important cause of blindness in adults, and is characterized by progressive loss of vascular cells and slow dissolution of inter-vascular junctions, which result in vascular leakage and retinal oedema. Later stages of the disease are characterized by inflammatory cell infiltration, tissue destruction and neovascularization. Here we identify soluble epoxide hydrolase (sEH) as a key enzyme that initiates pericyte loss and breakdown of endothelial barrier function by generating the diol 19,20-dihydroxydocosapentaenoic acid, derived from docosahexaenoic acid. The expression of sEH and the accumulation of 19,20-dihydroxydocosapentaenoic acid were increased in diabetic mouse retinas and in the retinas and vitreous humour of patients with diabetes. Mechanistically, the diol targeted the cell membrane to alter the localization of cholesterol-binding proteins, and prevented the association of presenilin 1 with N-cadherin and VE-cadherin, thereby compromising pericyte-endothelial cell interactions and inter-endothelial cell junctions. Treating diabetic mice with a specific sEH inhibitor prevented the pericyte loss and vascular permeability that are characteristic of non-proliferative diabetic retinopathy. Conversely, overexpression of sEH in the retinal Müller glial cells of non-diabetic mice resulted in similar vessel abnormalities to those seen in diabetic mice with retinopathy. Thus, increased expression of sEH is a key determinant in the pathogenesis of diabetic retinopathy, and inhibition of sEH can prevent progression of the disease.

Published
2017

12. A Hybrid Recommendation Model Based on Time Dimension for Academic Teams

Author

Tang, Yong, Lin, Jihong, Chu, Hanlu, He, Junyi, Luo, Fengjie, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Tang, Yong, editor, Zu, Qiaohong, editor, and Rodríguez García, José G., editor

Published
2019
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14. Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity

Author

Hu, Jiong, Bibli, Sofia-Iris, Wittig, Janina, Zukunft, Sven, Lin, Jihong, Hammes, Hans-Peter, Popp, Rudiger, and Fleming, Ingrid

Subjects
Thermo Fisher Scientific Inc., Nitration -- Physiological aspects, Hydrolases -- Physiological aspects, Omega 3 fatty acids -- Physiological aspects, Unsaturated fatty acids -- Physiological aspects, Tyrosine -- Physiological aspects, Childhood vision disorders -- Prevention -- Physiological aspects, Dietary supplements -- Physiological aspects, Mitochondrial DNA -- Physiological aspects, Scientific equipment industry -- Physiological aspects, Retinopathy of prematurity -- Prevention -- Physiological aspects, Infants, Phenols (Class of compounds), DNA, DNA damage, Fatty acids, Monosaccharides, Enzymes, Glycols (Class of compounds), Health care industry
Abstract

Polyunsaturated fatty acids such as docosahexaenoic acid (DHA) positively affect the outcome of retinopathy of prematurity (ROP). Given that DHA metabolism by cytochrome P450 and soluble epoxide hydrolase (sEH) enzymes affects retinal angiogenesis and vascular stability, we investigated the role of sEH in a mouse model of ROP. In WT mice, hyperoxia elicited tyrosine nitration and inhibition of sEH and decreased generation of the DHA-derived diol 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP). Correspondingly, in a murine model of ROP, [sEH.sup.-/-] mice developed a larger central a vascular zone and peripheral pathological vascular tuft formation than did their WT littermates. Astrocytes were the cells most affected by Seh deletion, and hyperoxia increased astrocyte apoptosis. In rescue experiments, 19,20-DHDP prevented astrocyte loss by targeting the mitochondrial membrane to prevent the hyperoxia-induced dissociation of presenilin-1 and presenilin-1-associated protein to attenuate poly ADP-ribose polymerase activation and mitochondrial DNA damage. Therapeutic intravitreal administration of 19,20-DHDP not only suppressed astrocyte loss, but also reduced pathological vascular tuft formation in [sEH.sup.-/-] mice. Our data indicate that sEH activity is required for mitochondrial integrity and retinal astrocyte survival in ROP. Moreover, 19,20-DHDP may be more effective than DHA as a nutritional supplement for preventing retinopathy in preterm infants., Introduction Retinopathy of prematurity (ROP) is a complication of treating preterm infants with [O.sub.2]. It is estimated that as many as 10% of very premature infants become blind as a [...]

Published
2019
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16. Radiologic Identification of Pathologic Tumor Invasion in Patients With Lung Adenocarcinoma

Author

Ye, Ting, primary, Wu, Haoxuan, additional, Wang, Shengping, additional, Li, Qiao, additional, Gu, Yajia, additional, Ma, Junjie, additional, Lin, Jihong, additional, Kang, Mingqiang, additional, Qian, Bin, additional, Hu, Hong, additional, Zhang, Yang, additional, Sun, Yihua, additional, Zhang, Yawei, additional, Xiang, Jiaqing, additional, Li, Yuan, additional, Shen, Xuxia, additional, Wang, Zezhou, additional, and Chen, Haiquan, additional

Published
2023
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35. The role of EEF1D in disease pathogenesis: a narrative review

Author

Xu, Hui, primary, Yu, Shaobin, additional, Peng, Kaiming, additional, Gao, Lei, additional, Chen, Sui, additional, Shen, Zhimin, additional, Han, Ziyang, additional, Chen, Mingduan, additional, Lin, Jihong, additional, Chen, Shuchen, additional, and Kang, Mingqiang, additional

Published
2021
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43. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

Author

Hammes, Hans-Peter, Du, Xueliang, Edelstein, Diane, Taguchi, Tetsuya, Matsumura, Takeshi, Ju, Qida, Lin, Jihong, Bierhaus, Angelika, Nawroth, Peter, Hannak, Dieter, Neumaier, Michael, Bergfeld, Regine, Giardino, Ida, and Brownlee, Michael

Abstract

Three of the major biochemical pathways implicated in the pathogenesis of hyperglycemia induced vascular damage (the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)-protein kinase C (PKC) pathway) are activated by increased availability of the glycolytic metabolites glyceraldehyde-3-phosphate and fructose-6-phosphate. We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-[kappa]B activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars. In retinas of diabetic animals, benfotiamine treatment inhibited these three pathways and NF-[kappa]B activation by activating transketolase, and also prevented experimental diabetic retinopathy. The ability of benfotiamine to inhibit three major pathways simultaneously might be clinically useful in preventing the development and progression of diabetic complications., Author(s): Hans-Peter Hammes [1]; Xueliang Du [2]; Diane Edelstein [2]; Tetsuya Taguchi [2]; Takeshi Matsumura [2]; Qida Ju [2]; Jihong Lin [1]; Angelika Bierhaus [3]; Peter Nawroth [3]; Dieter Hannak [...]

Published
2003
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45. CaM Kinase II-δ is required for diabetic hyperglycemia and retinopathy but not nephropathy

Author

Chen, Jessy, primary, Fleming, Thomas, primary, Katz, Sylvia, primary, Dewenter, Matthias, primary, Hofmann, Kai, primary, Saadatmand, Alireza, primary, Kronlage, Mariya, primary, Werner, Moritz P., primary, Pokrandt, Bianca, primary, Schreiter, Friederike, primary, Lin, Jihong, primary, Katz, Daniel, primary, Morgenstern, Jakob, primary, Elwakiel, Ahmed, primary, Sinn, Peter, primary, Gröne, Hermann-Josef, primary, Hammes, Hans-Peter, primary, Nawroth, Peter P., primary, Isermann, Berend, primary, Sticht, Carsten, primary, Brügger, Britta, primary, Katus, Hugo A., primary, Hagenmueller, Marco, primary, and Backs, Johannes, primary

Published
2020
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48. Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease

Author

Lin, Jihong, primary, Hu, Jiong, additional, Schlotterer, Andrea, additional, Wang, Jing, additional, Kolibabka, Matthias, additional, Awwad, Khader, additional, Dietrich, Nadine, additional, Breitschopf, Kristin, additional, Wohlfart, Paulus, additional, Kannt, Aimo, additional, Lorenz, Katrin, additional, Feng, Yuxi, additional, Popp, Rüdiger, additional, Hoffmann, Sigrid, additional, Fleming, Ingrid, additional, and Hammes, Hans Peter, additional

Published
2020
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