Search

Sleep apnea, due to the induced hipoxia, leads to severe sleep disturbances and has negative consequences on the physical and psychological health status. The oxidative stress is involved in the pathogenic mechanism of this syndrome. Natural antioxidant supplementation equilibrates the oxidants/antioxidants balance and reduces the effects of the reactive oxygen species. We used 40 male Wistar rates divides into four equal groups. Two of them (I, II) had been kept in atmospheric air, while the other two (III, IV) had been exposed to chronic intermittent hypoxia. Two groups (II, IV) received a daily supplement of polyphenols extracted from grape seeds. After 14 days the spatial learning capacity of all the animals was tested using Morris water maze; then serum and brains samples have been taken in order to asses the parameters of the oxidative stress. We identified an increase in the oxidative stress parameters and a decreased learning ability in the rats exposed to hypoxia. The polyphenols extract improved both the biochemical and the cognitive parameters. [ABSTRACT FROM AUTHOR]

Copyright of Acta Medica Transilvanica is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Medica Transilvanica is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)