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3. Erratum to VegItaly: The Italian collaborative project for a national vegetation database (Plant Biosystems, 146, 4 (756-763))

Author

Landucci, F., Acosta, A. T. R., Agrillo, E., Attorre, F., Biondi, E., Cambria, V. E., Del Vico, E., de Sanctis, M., Facioni, L., Geri, F., Gigante, D., Guarino, R., Lucarini, D., Panfili, E., Pesaresi, S., Prisco, I., Rosati, L., Spada, F., Venanzoni, R., CHIARUCCI, ALESSANDRO, LANDI, SARA, Landucci, F., Acosta, A.T.R., Agrillo, E., Attorre, F., Biondi, E., Cambria, V.E., Chiarucci, A., Del Vico, E., de Sanctis, M., Facioni, L., Geri, F., Gigante, D., Guarino, R., Landi, S., Lucarini, D., Panfili, E., Pesaresi, S., Prisco, I., Rosati, L., Spada, F., and Venanzoni, R.

Subjects
Plant Science, Ecology, Evolution, Behavior and Systematics
Published
2013

4. A web collaborative project to store and map botanical data

Author

Venanzoni R, Aleffi M, Assini S, Bonini I, Chiarucci A, Feoli E, Gigante D, Foggi B, Geri F, Gubellini L, Landucci F, Lastrucci L, Lucarini D, Maneli F, Mariotti M, Panfili E, Peccenini S, Perini C, Rosati L, Santangelo A, Strumia S, Taffetani F, Vanacore Falco R, Viciani D, Vidali M, Tacchi R, Zuccarello V., GUARINO, Riccardo, Venanzoni R, Aleffi M, Assini S, Bonini I, Chiarucci A, Feoli E, Gigante D, Guarino R, Foggi B, Geri F, Gubellini L, Landucci F, Lastrucci L, Lucarini D, Maneli F, Mariotti M, Panfili E, Peccenini S, Perini C, Rosati L, Santangelo A, Strumia S, Taffetani F, Vanacore Falco R, Viciani D, Vidali M, Tacchi R, and Zuccarello V

Subjects
Settore BIO/03 - Botanica Ambientale E Applicata, data-base, vegetation, flora, herbarium specimens
Published
2013

6. VegItaly: Technical features, crucial issues and some solutions

Author

Gigante, D, Acosta, A, Agrillo, E, Attorre, F, Cambria, V, Casavecchia, S, Chiarucci, A, Del Vico, E, De Sanctis, M, Facioni, L, Geri, F, Landi, S, Landucci, F, Lucarini, D, Panfili, E, Pesaresi, S, Prisco, I, Rosati, L, Spada, F, Venanzoni, R., GUARINO, Riccardo, Daniela Gigante, Alicia T.R. Acosta, Emiliano Agrillo, Fabio Attorre, V.E. Cambria, Simona Casavecchia, Alessandro Chiarucci, Eva Del Vico, Michele De Sancti, Laura Facioni, Francesco Geri, Riccardo Guarino, Sara Landi, Flavia Landucci, Domenico Lucarini, Edoardo Panfili, Simone Pesaresi, Irene Prisco, Leonardo Rosati, Francesco Spada, Roberto Venanzoni, Gigante, D, Acosta, A, Agrillo, E, Attorre, F, Cambria, V, Casavecchia, S, Chiarucci, A, Del Vico, E, De Sanctis, M, Facioni, L, Geri, F, Guarino, R, Landi, S, Landucci, F, Lucarini, D, Panfili, E, Pesaresi, S, Prisco, I, Rosati, L, Spada, F, and Venanzoni, R

Subjects
Data sharing, Ecoinformatics, Italian vegetation database, Phytosociology, Syntaxonomy, Taxonomic listVegetation plot, Forestry, Ecology, Evolution, Behavior and Systematics, Ecology, Plant Science, Evolution, DATABASE, data sharing, phytosociology, data sharing, ecoinformatics, Italian vegetation database, phytosociology, syntaxonomy, taxonomic list, vegetation plot, ecoinformatics, taxonomic list, Behavior and Systematics, vegetation science, italian vegetation database, syntaxonomy, taxonomic listvegetation plot, vegetation plot, Settore BIO/03 - Botanica Ambientale E Applicata
Abstract

VegItaly is at present the largest Italian vegetation database. It is the result of a collaborative project aspiring to represent a major reference for the Italian vegetation scientists. The paper emphasizes its benefits for phytosociological data management and describes the solutions adopted to solve several technical problems, like the treatment of different vegetation stratification systems, the conversion of vegetation cover values, taxonomic and syntaxonomic issues, data import and access. The structure of the taxonomic list produced to support the storing of data is described. It allows an easy management of synonymic relationships and is constantly updated according to new publications and revisions. Issues related to data import from different formats have been solved by developing assistant software VegImport and TabImport, which are based on the most used formats in vegetation plot archiving. Bibliographic sources are managed according to the LISY standard and include descriptive geographic information, bibliographic and syntaxonomic reference. Distinct data access regimes can be selected by VegItaly's users: visible, partly visible, invisible. Compared with the original project outline, many fundamental parts of the database structure have been fully built up, although several utilities still have to be developed or improved. © Italian Society for Vegetation Science.

Published
2012

7. VegItaly: Technical features, crucial issues and some solutions

Author

Gigante D, T, Agrillo E, Attorre F, Cambria V. E, Casavecchia S, Chiarucci A, Del Vico E, De Sanctis M, Facioni L, Geri F, Guarino R, Landi S, Landucci F, Lucarini D, Panfili E, Pesaresi S, Prisco I, Rosati L, Spada F, Venanzoni R., ACOSTA, ALICIA TERESA ROSARIO, Gigante, D, Acosta, ALICIA TERESA ROSARIO, T, Agrillo, E, Attorre, F, Cambria V., E, Casavecchia, S, Chiarucci, A, Del Vico, E, De Sanctis, M, Facioni, L, Geri, F, Guarino, R, Landi, S, Landucci, F, Lucarini, D, Panfili, E, Pesaresi, S, Prisco, I, Rosati, L, Spada, F, and Venanzoni, R.

Published
2012

8. Improvements and open issues of the database VegItaly. What are the perspectives?

Author

Landucci, F., Acosta, A. T. R., Agrillo, E., Attorre, F., Cambria, V. E., Casavecchia, S., Chiarucci, A., Del Vico, E., De Sanctis, M., Facioni, L., Geri, F., Gigante, D., Guarino, R., Landi, S., Lucarini, D., Panfili, E., Pesaresi, S., Prisco, I., Rosati, L., Spada, F., and Venanzoni, R.

Subjects
archive, vegetation, phytosociology
Published
2013

9. A web collaborative project to store and mapping botanical data

Author

Venanzoni, R., Aleffi, M., Assini, S., Bonini, I., Chiarucci, A., Feoli, E., Gigante, D., Guarino, R., Foggi, B., Geru, F., Gubellini, L., Landucci, F., Lastrucci, L., Lucarini, D., Maneli, F., Mariotti, Mauro, Poponessi, S., Panfili, E, Peccenini, Simonetta, Perini, C., Rosati, L., Santangelo, A., Strumia, S., Taffetani, F., Vanacore Falco, R., Viciani, D., Vidali, M., and Zuccarello, V.

Published
2013

10. ECOSYSTEM FRAGILITY TO ALIEN AND INVASIVE SPECIES

Author

Corriero, G, Acost, A, Allegrini, Mc, Austoni, M, Barbone, N, Bartolozzi, L, Basset, A, Bastianini, M, Bavestrello, G, Bernardi Aubry, F, Boero, F, Boggero, A, Buia, Mc, Cabrini, M, Campanaro, A, Campetella, G, Canullo, R, Cardone, F, Carranza, Ml, Cataletto, B, Cattaneo, A, Cattaneo Vietti, R, Cavraro, F, Cecere, E, Cervellini, M, Cesaroni, D, Chelli, S, Chiapparelli, S, Cianferoni, F, Cibic, T, Cocciufa, C, Elia, Antonia Concetta, De Felici, S, De Olazabal, A, D'Onghia, G, Finotto, S, Fiore, N, Fontaneto, D, Fornasaro, D, Franzoi, P, Fraschetti, S., Frate, L, Fuentes, D, Gaino, Elda Rosa, Gaudiano, L., Giangrande, A, Goretti, Enzo, Ingrosso, W, Keppel, E, Labadessa, R, LA PORTA, Gianandrea, Longo, C, Lorenti, M, Lorenzoni, Massimo, Lucarini, D, Ludovisi, Alessandro, Malavasi, S, Manca, M, Maiorano, P, Marchetto, A, Marra, M, Doerr, Ambrosius J. Martin, Mastrototaro, F, Mazzocchi, Mg, Minari, E, Mistri, M, Monti, M, Morabito, G, Munari, C, Nonnis Marzano, C, Oggioni, A, Patti, Fp, Pelino, G, Petrocelli, A, Pierri, C, Pugnetti, A, Riccarducci, G, Rosati, I, Riccardi, N, Santoro, R, Sarno, D., Sbordoni, V, Sorino, R, Scipione, B, Sigovini, M, Sion, L, Stanisci, A, Tagliapietra, D, Tirelli, V, Tursi, A, Ungaro, N, Volta, P, Zingone, A, Zucchetta, M, and Zupo, V.

Subjects
ECOSYSTEM FRAGILITY, LIFEWATCH, BIODIVERSITY, TO ALIEN SPECIES
Published
2012

11. La Banca Dati della Vegetazione Italiana VegItaly

Author

Venanzoni, Roberto, Acosta, A. T. R., Agrillo, E., Attorre, F., Biondi, E., Chiarucci, A., Del Vico, E., De Sanctis, M., Geri, F., Gigante, Daniela, Guarino, R., Landucci, Flavia, Lucarini, D., Panfili, E., Pesaresi, S., Rosati, L., Spada, F., and Blasi, C.

Subjects
floristic and vegetation data, phytosociologic relevé, Vegetation databank
Published
2012

16. Integrazioni alla checklist della flora vascolare italiana - Updating of the checklist of the Italian Vascular Flora

Author

Conti, F, Alessandrini, A, Bacchetta, G, Banfi, E, Barberis, GIUSEPPINA ALBINA, Bartolucci, F, Bernardo, L, Bonacquisti, S, Bouvet, D, Bovio, M, Brusa, G, DEL GUACCHIO, E, Foggi, B, Frattini, S, Galasso, G, Gallo, L, Vangale, C, Gottlschlich, G, Grunanger, P, Gubellini, L, Iiriti, G, Lucarini, D, Marchetti, D, Moraldo, B, Peruzzi, L, Poldini, L, Prosser, F, Raffaelli, M, Santangelo, A, Scassellati, E, Scortegagna, S, Selvi, F, Soldano, A, Tinti, D, Ubaldi, D, Uzunov, D, and Vidali, M.

Published
2007

20. VegItaly: The Italian collaborative project for a national vegetation database

Author

Landucci, F., primary, Acosta, A. T. R., additional, Agrillo, E., additional, Attorre, F., additional, Biondi, E., additional, Cambria, V. E., additional, Chiarucci, A., additional, Del Vico, E., additional, De Sanctis, M., additional, Facioni, L., additional, Geri, F., additional, Gigante, D., additional, Guarino, R., additional, Landi, S., additional, Lucarini, D., additional, Panfili, E., additional, Pesaresi, S., additional, Prisco, I., additional, Rosati, L., additional, Spada, F., additional, and Venanzoni, R., additional

Published
2012
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21. The anArchive taxonomic Checklist for Italian botanical data banking and vegetation analysis: Theoretical basis and advantages.

Author

Lucarini, D., Gigante, D., Landucci, F., Panfili, E., and Venanzoni, R.

Subjects
*BOTANICAL databases, *BOTANICAL nomenclature, *HABITATS, *PLANT chemical analysis, *PLANT classification
Abstract

In recent years, research in botany was increasingly related with the use of large data-sets and data banks, in order to address emerging issues such as the severe risk of species, habitats and biodiversity loss. In this frame, theanArchivetaxonomic Checklist, an online synonymized list of botanical species names, developed to support the botanical data banking and vegetation analysis, is presented and discussed here. The benefits deriving from such a supervised and referenced tool are emphasized. They include the possibility to keep track of old and new species names, pointing out the latest reviewed accepted scientific name and its synonyms, and harmonizing different taxonomic points of view. Furthermore, the list is open access and expert qualified customers can collaborate to its improvement. The basic unit of the taxonomic Checklist is an object including thetaxonname at specific or, when present, infraspecific level; the taxonomic frame stops at the level of family and ranks higher than genus are not treated hierarchically. Some technical features, the main taxonomic references and the current state of the art are reported. [ABSTRACT FROM PUBLISHER]

Published
2015
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23. Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for squamous cell carcinoma of the head and neck: long-term results.

Author

Clark, J R, primary, Busse, P M, additional, Norris, C M, additional, Andersen, J W, additional, Dreyfuss, A I, additional, Rossi, R M, additional, Poulin, M D, additional, Colevas, A D, additional, Tishler, R B, additional, Costello, R, additional, Lucarini, J W, additional, Lucarini, D, additional, Thornhill, L, additional, Lackey, M, additional, Peters, E, additional, and Posner, M R, additional

Published
1997
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25. Notulae To The Italian Native Vascular Flora: 11

Author

Davide Dagnino, Nicole Hofmann, Roberto Marchianò, Goffredo Filibeck, Carmelo Maria Musarella, Fabrizio Bonali, Riccardo Pennesi, Lorenzo Lastrucci, Giacomo Mei, Giulio Ferretti, Flavio Menini, Agostino Brusco, Duilio Iamonico, Gianniantonio Domina, Gianluca Piovesan, Valentina Laface, Francesco Roma-Marzio, Antonio Pica, G. Barberis, M. Bovio, A. Gabellini, Laura Cancellieri, L. Gubellini, Paolo Marenzi, Leonardo Rosati, Marco Martignoni, Rossano Bolpagni, Carlo Argenti, Jacopo Lupoletti, Sandro Ballelli, Lorenzo Antonino Gianguzzi, Emanuele Del Guacchio, Gabriele Galasso, Marco Merli, Lorenzo Pinzani, Bruno Foggi, Gianluigi Bacchetta, Michele Lonati, Sarah Tonelli, Davide Barberis, Simone Ravetto Enri, Maurizio Trenchi, Luciana Carotenuto, Lina Podda, Marco Pittarello, Giovanni Spampinato, Enrico Banfi, Giuliano Campus, Emanuele Cheli, Fabrizio Bartolucci, Claudia Turcato, Adriano Stinca, Daniele Viciani, Orazio Caldarella, Domenico Lucarini, Emmanuele Farris, Sebastiano Andreatta, Gianni Bedini, Ian Briozzo, Simonetta Peccenini, Günter Gottschlich, Simone Orsenigo, Lorenzo Peruzzi, Bartolucci, F., Domina, G., Andreatta, S., Argenti, C., Bacchetta, G., Ballelli, S., Banfi, E., Barberis, D., Barberis, G., Bedini, G., Bolpagni, R., Bonali, F., Bovio, M., Briozzo, I., Brusco, A., Caldarella, O., Campus, G., Cancellieri, L., Carotenuto, L., Cheli, E., Dagnino, D., Guacchio, E. D., Farris, E., Ferretti, G., Filibeck, G., Foggi, B., Gabellini, A., Galasso, G., Gianguzzi, L., Gottschlich, G., Gubellini, L., Hofmann, N., Iamonico, D., Laface, V. L. A., Lonati, M., Lucarini, D., Lupoletti, J., Marchiano, R., Marenzi, P., Martignoni, M., Mei, G., Menini, F., Merli, M., Musarella, C. M., Orsenigo, S., Peccenini, S., Pennesi, R., Peruzzi, L., Pica, A., Pinzani, L., Piovesan, G., Pittarello, M., Podda, L., Enri, S. R., Roma-Marzio, F., Rosati, L., Spampinato, G., Stinca, A., Tonelli, S., Trenchi, M., Turcato, C., Viciani, D., Lastrucci, L., and BARTOLUCCI F., DOMINA G., ANDREATTA S., ARGENTI C., BACCHETTA G., BALLELLI S., BANFI E., BARBERIS D., BARBERIS G., BEDINI G., BOLPAGNI R., BONALI F., BOVIO M., BRIOZZO I., BRUSCO A., CALDARELLA O., CAMPUS G., CANCELLIERI L., CAROTENUTO L., CHELI E., DAGNINO D., DEL GUACCHIO E., FARRIS E., FERRETTI G., FILIBECK F., FOGGI B., GABELLINI A., GALASSO G., GIANGUZZI L., GOTTSCHLICH G., GUBELLINI L., HOFMANN N., IAMONICO D., LAFACE V.L.A., LONATI M., LUCARINI D., LUPOLETTI J., MARCHIANÒ R., MARENZI P., MARTIGNONI M., MEI G., MENINI F., MERLI M., MUSARELLA C.M., ORSENIGO S., PECCENINI S., PENNESI R., PERUZZI L., PICA A., PINZANI L., PIOVESAN G., PITTARELLO M., PODDA L., RAVETTO ENRI S., ROMA-MARZIO F., ROSATI L., SPAMPINATO G., STINCA A., TONELLI S., TRENCHI M., TURCATO C., VICIANI D., LASTRUCCI L.

Subjects
0106 biological sciences, Flora, Endemic taxa, Endemic taxa, Floristic data, Italy, Floristic data, Italy, Botany, Zoology, Plant Science, Biology, 010603 evolutionary biology, 01 natural sciences, QK1-989, Settore BIO/03 - Botanica Ambientale E Applicata, Ecology, Evolution, Behavior and Systematics, 010606 plant biology & botany
Abstract

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations, exclusions, and status changes to the Italian administrative regions. A new combination in the genus Pilosella is proposed. Nomenclatural and distribution updates, published elsewhere, and corrigenda are provided as Suppl. material 1.

Published
2021

26. VegItaly: The Italian collaborative project for a national vegetation database

Author

L. Facioni, Francesco Geri, Francesco Spada, Emiliano Agrillo, Daniela Gigante, Domenico Lucarini, I. Prisco, E. Panfili, Alessandro Chiarucci, Riccardo Guarino, S. Pesaresi, Edoardo Biondi, Roberto Venanzoni, E. Del Vico, Alicia Teresa Rosario Acosta, Sara Landi, Fabio Attorre, M. C. De Sanctis, Flavia Landucci, V. E. Cambria, Leonardo Rosati, LANDUCCI F., ACOSTA A.T.R., AGRILLO E., ATTORRE F., BIONDI E., CAMBRIA V.E., CHIARUCCI A., DEL VICO E., DE SANCTIS M., FACIONI L., GERI F., GIGANTE D., GUARINO R., LANDI S., LUCARINI D., PANFILI E., PESARESI S., PRISCO I., ROSATI L., SPADA F., VENANZONI R., Landucci, F, Acosta, ATR, Agrillo, E, Attorre, F, Biondi, E, Cambria, VE, Chiarucci, A, Del Vico, E, De Sanctis, M, Facioni, L, Geri, F, Gigante, D, Guarino, R, Landi, S, Lucarini, D, Panfili, E, Pesaresi, S, Prisco, I, Rosati, L, Spada, F, Venanzoni, R, Landucci, F., Acosta, A. T. R., Agrillo, E., Attorre, F., Biondi, E., Cambria, V. E., Chiarucci, A., Del Vico, E., De Sanctis, M., Facioni, L., Geri, F., Gigante, D., Guarino, R., Landi, S., Lucarini, D., Panfili, E., Pesaresi, S., Prisco, I., Rosati, L., Spada &amp, F., and Venanzoni, R.

Subjects
phytosociology, Distribution (economics), relevé, Plant Science, Biodiversity informatics, computer.software_genre, Plot (graphics), Vegetation types, database, vegetation plot, medicine, Ecology, Evolution, Behavior and Systematics, Database, business.industry, biodiversity informatics, vegetation-plot, releve, Geography, Biodiversity informatics, database, phytosociology, releve´, vegetation plot, Settore BIO/03 - Botanica Ambientale E Applicata, Biodiversity informatic, medicine.symptom, Large group, business, Vegetation (pathology), computer
Abstract

Two years after its official start, the national vegetation database VegItaly, a collaborative project supported by the Italian scientific community and developed by a large group of scientists, is presented. This article offers a concise overview of the content of the database, currently consisting of 31,100 vegetation plot, including published and unpublished data. Some basic statistics are analysed; for example, data distribution in space and time, represented vegetation types expressed as physiognomic categories. Although rather young and still in progress, VegItaly already contains data from all the Italian regions and stands as an optimal candidate for the development of an Italian national vegetation database. Its main goals,theoretical basis, technical features, functionalities and recent progresses are outlined, showing glimpses of future prospects.

Published
2012

27. Integrazioni alla Checklist della flora vascolare italiana

Author

Conti, Fabio, Alessandrini, A., Bacchetta, G., Banfi, E., Barberis, G., Bartolucci, Fabrizio, Bernardo, L., Bonacquisti, S., Bouvet, D., Bovio, M., Brusa, G., DEL GUACCHIO, E., Foggi, B., Frattini, S., Galasso, G., Gallo, L., Gangale, C., Gottschlich, G., Grünanger, P., Gubellini, L., Iiriti, G., Lucarini, Domenico, Marchetti, D., Moraldo, B., Peruzzi, L., Poldini, L., Prosser, F., Raffaelli, M., Santangelo, A., Scassellati, Elisabetta, Scortegagna, S., Selvi, F., Soldano, A., Tinti, D., Ubaldi, D., Uzunov, D., Vidali, M., Conti, F., Alessandrini, A., Bacchetta, G., Banfi, E., Barberis, G., Bartolucci, F., Bernardo, L., Buonacquisti, S., Bouvet, D., Bovio, M., Brusa, G., Del Guacchio, E., Foggi, B., Frattini, S., Galasso, G., Galo, G., Gangale, C., Gottschhlich, G., Grunanger, P., Gubellini, L., Iiriti, Lucarini, D., Marchetti, D., Moraldo, B., Peruzzi, L., Poldini, L., Prosser, F., Raffaelli, M., Santangelo, Annalisa, Scassellati, E., Scortegagna, S., Selvi, F., Soldano, A., Tinti, D., Ubaldi, D., Uzunov, D., and Vidali, M.

Published
2007

28. Secondary Metabolites, Glandular Trichomes and Biological Activity of Sideritis montana L. subsp. montana from Central Italy.

Author

Venditti A, Bianco A, Frezza C, Serafini M, Giacomello G, Giuliani C, Bramucci M, Quassinti L, Lupidi G, Lucarini D, Papa F, and Maggi F

Subjects
Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic metabolism, Antioxidants chemistry, Antioxidants metabolism, Cell Line, Tumor, Cell Proliferation drug effects, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Humans, Italy, Molecular Structure, Oils, Volatile chemistry, Oils, Volatile metabolism, Sideritis metabolism, Structure-Activity Relationship, Trichomes metabolism, Antineoplastic Agents, Phytogenic pharmacology, Antioxidants pharmacology, Oils, Volatile pharmacology, Secondary Metabolism, Sideritis chemistry, Trichomes chemistry
Abstract

Sideritis montana subsp. montana is a small annual herb occurring in countries bordering the Mediterranean and Balkan regions. The secondary metabolism of this plant has not been fully explored so far. The aim of the present study was to understand the complex mixture of secondary metabolites and the type of secretory structures. The polar constituents were isolated by column chromatography from the ethanolic extract, and their structure was elucidated by NMR and MS. The essential oil was isolated by hydrodistillation and analysed by GC/MS. The plant indumentum was studied by light and scanning electron microscopy. To complete the work, the essential oil antioxidant activity and cytotoxicity on tumor cells were evaluated by DPPH, ABTS, FRAP, and MTT methods. Four different classes of secondary metabolites were isolated, namely flavonoids, caffeoylquinic derivatives, glycosidic hydroquinones and iridoids. The essential oil was mainly characterized by sesquiterpenene hydrocarbons. Peltate and long-capitate hairs were the main sites where terpenes and polar constituents are produced. The secondary metabolites found in S. montana subsp. montana are of chemotaxonomic interest, some of them being typical of the genus Sideritis. The trichomes types observed partially differ from those described in other members of the genus Sideritis. The essential oil showed noteworthy inhibition on tumor cells., (© 2016 Wiley-VHCA AG, Zürich.)

Published
2016
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29. Phytochemical Analysis, Biological Activity, and Secretory Structures of Stachys annua (L.) L. subsp. annua (Lamiaceae) from Central Italy.

Author

Venditti A, Bianco A, Quassinti L, Bramucci M, Lupidi G, Damiano S, Papa F, Vittori S, Maleci Bini L, Giuliani C, Lucarini D, and Maggi F

Subjects
Cell Line, Tumor, Flowers chemistry, Humans, Italy, Neoplasms drug therapy, Phytol chemistry, Phytol pharmacology, Plant Oils chemistry, Plant Oils pharmacology, Sesquiterpenes chemistry, Sesquiterpenes pharmacology, Sesquiterpenes, Germacrane chemistry, Sesquiterpenes, Germacrane pharmacology, Trichomes chemistry, Trichomes ultrastructure, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Antioxidants chemistry, Antioxidants pharmacology, Oils, Volatile chemistry, Oils, Volatile pharmacology, Stachys chemistry
Abstract

Stachys annua subsp. annua, well-known in central Italy as 'stregona annuale', is an annual, small, slightly-scented herb, commonly found in fields and uncultivated areas in almost all regions of Italy. In folk medicine, its aerial parts were used as anti-catarrhal, febrifuge, tonic, and vulnerary. In the present work, the chemical composition of the flowering aerial parts was studied. The hydrodistilled volatile oil, analysed by GC/MS, showed sesquiterpenoids as the major fraction (42.5%); phytol (9.8%), germacrene D (9.2%), and spathulenol (8.5%) were the most abundant constituents. The volatile oil was assayed for antioxidant and cytotoxic activity by DPPH, ABTS, FRAP, and MTT methods. The cytotoxicity results against HCT116, A375, and MDA-MB 231 human tumor cell lines were significant, with IC50 values of 23.5, 37.2, and 41.5 μg/ml, respectively, whereas the antioxidant power was negligible. The EtOH extract was composed mainly of three glycosidic flavonoids, namely 7-{[2-O-(6-O-acetyl-β-D-allopyranosyl)-β-D-glucopyranosyl]oxy}-5,8-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one (1), 7-{[6-O-acetyl-2-O-(6-O-acetyl-β-D-allopyranosyl)-β-D-glucopyranosyl]oxy}-2-(3,4-dihydroxyphenyl)-5,8-dihydroxy-4H-1-benzopyran-4-one (2), and 7-{[6-O-acetyl-2-O-(β-D-allopyranosyl)-β-D-glucopyranosyl]oxy}-2-(3-hydroxy-4-methoxyphenyl)-5,8-dihydroxy-4H-1-benzopyran-4-one (3). On the contrary, iridoids, considered chemotaxonomic markers of the genus Stachys, were absent in this species. Finally, the morphological and histochemical survey showed that glandular trichomes were composed of two main types, i.e. peltate type A and capitate types B and C giving positive response for both lipids and polyphenols., (Copyright © 2015 Verlag Helvetica Chimica Acta AG, Zürich.)

Published
2015
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30. Phytochemical analysis, biological evaluation and micromorphological study of Stachys alopecuros (L.) Benth. subsp. divulsa (Ten.) Grande endemic to central Apennines, Italy.

Author

Venditti A, Bianco A, Nicoletti M, Quassinti L, Bramucci M, Lupidi G, Vitali LA, Petrelli D, Papa F, Vittori S, Lucarini D, Maleci Bini L, Giuliani C, and Maggi F

Subjects
Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Antioxidants isolation & purification, Antioxidants pharmacology, Bacteria drug effects, Cell Line, Tumor, Classification, Flowering Tops chemistry, Humans, Iridoids isolation & purification, Italy, Oils, Volatile chemistry, Oils, Volatile pharmacology, Phytotherapy, Plant Extracts chemistry, Plant Extracts pharmacology, Plant Extracts therapeutic use, Sesquiterpenes isolation & purification, Sesquiterpenes pharmacology, Stachys classification, Stachys ultrastructure, Antineoplastic Agents, Phytogenic therapeutic use, Antioxidants therapeutic use, Neoplasms drug therapy, Oils, Volatile therapeutic use, Sesquiterpenes therapeutic use, Stachys chemistry, Trichomes ultrastructure
Abstract

Stachys alopecuros subsp. divulsa (Lamiaceae), a perennial herb endemic to central Italy growing on mountain pastures, was investigated for the first time for the content of secondary metabolites, for the micromorphology and histochemistry of glandular trichomes, and for the biological activity of the volatile oil, namely cytotoxic, antioxidant and antimicrobial. The plant showed the molecular pattern of iridoids, among which a new iridoid diglycoside (4'-O-β-D-galactopyranosyl-teuhircoside) was detected, together with a sterol glucoside and a phenylethanoid glycoside. The essential oil from the flowering aerial parts was characterized by a high proportion of sesquiterpene hydrocarbons (65.1%), with (E)-caryophyllene (33.2%) as the most abundant, while other main components were germacrene D (7.6%), α-humulene (6.4%) and the oxygenated cis-sesquisabinene hydrate (10.2%). Taken together, polar and apolar chemical profiles support the classification of the species within the section Betonica of the genus Stachys. Micromorphological study revealed three types of glandular hairs secreting different classes of compounds, with type A peltate hairs producing the bulk of the essential oil. MTT assay revealed the potential of the volatile oil in inhibiting A375, HCT116 and MDA-MB 231 tumor cells (IC₅₀ values below 20 μg/ml)., (© 2013.)

Published
2013
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31. Glandular trichomes and essential oil composition of endemic Sideritis italica (Mill.) Greuter et Burdet from central Italy.

Author

Giuliani C, Bini LM, Papa F, Cristalli G, Sagratini G, Vittori S, Lucarini D, and Maggi F

Subjects
Italy, Microscopy, Electron, Scanning, Oils, Volatile chemistry, Plant Components, Aerial growth & development, Plant Components, Aerial ultrastructure, Plant Oils chemistry, Sideritis growth & development, Sideritis ultrastructure, Oils, Volatile isolation & purification, Plant Components, Aerial chemistry, Plant Oils isolation & purification, Sideritis chemistry
Abstract

Sideritis italica (Mill.) Greuter et Burdet belongs to the Lamiaceae family and is endemic to Italy. The glandular trichomes (morphology, distribution, histochemistry, and ultrastructure) of the plant were studied for the first time, along with the chemical composition of the essential oils. Abundant non-glandular hairs and peltate (type A) and capitate (types B, C(1), and C(x)) glandular trichomes were observed both on the vegetative and reproductive organs. The histochemical procedures and the ultrastructural investigation enabled specific location of the main site of essential oil production mainly in type-A peltate hairs. Particular emphasis is given to the release mechanism of the secreted material in all of the types of glands, and the potential taxonomic value of the indumentum in the Lamiaceae family is briefly discussed. Essential oils were hydrodistilled from flowering aerial parts of S. italica, and 136 compounds (112 in flowerheads, 79 in vegetative parts) were identified. The quantitative prevalence of diterpenoids (43.4% in flowerheads and 22.3% in vegetative parts) was the most significant characteristic of the essential oil of S. italica that could be classified as a diterpene-rich essential oil according to the classification of Kirimer., (Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.)

Published
2011
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32. Antimicrobial activity of seven hypericum entities from central Italy.

Author

Cecchini C, Cresci A, Coman MM, Ricciutelli M, Sagratini G, Vittori S, Lucarini D, and Maggi F

Subjects
Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Candida albicans drug effects, Ethnopharmacology, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Humans, Italy, Microbial Sensitivity Tests, Plant Components, Aerial, Plant Extracts administration & dosage, Plant Extracts therapeutic use, Anti-Bacterial Agents pharmacology, Hypericum, Phytotherapy, Plant Extracts pharmacology
Abstract

Methanol-acetone extracts from aerial parts of seven entities of the genus Hypericum [H. perforatum L. subsp. perforatum, H. perforatum L. subsp. veronense (Schrank) Ces., H. montanum L., H. hyssopifolium Chaix, H. hirsutum L., H. hircinum L. subsp. majus (Aiton) N. Robson, H. tetrapterum Fr.] growing in the Appennino Umbro-Marchigiano (central Italy) were tested in vitro for their antimicrobial activity against two Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis), two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and the yeast Candida albicans, by the Kirby-Bauer agar diffusion method. The two H. perforatum subspecies were particularly active against Gram-positive and Gram-negative bacteria, supporting the use of these plants in the traditional medicine of central Italy to treat wounds, skin and infectious diseases. However significant values of inhibition were given also by H. hirsutum against S. aureus and P. aeruginosa, and by H. hyssopifolium, H. hircinum subsp. majus and H. tetrapterum against C. albicans. These results suggest that hypericin and hyperforin are the main components responsible for antimicrobial activity, but not the only ones, as other extracts, showing a low level of these compounds, possess evident activity. Isolation of pure compounds from the most active extracts is in progress.

Published
2007
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33. [Preventive effect of thymomodulin in recurrent respiratory infections in children].

Author

Galli L, de Martino M, Azzari C, Bernardini R, Cozza G, de Marco A, Lucarini D, Sabatini C, and Vierucci A

Subjects
Child, Child, Preschool, Female, Humans, Interleukin-2 biosynthesis, Male, Recurrence, Respiratory Tract Infections immunology, Respiratory Tract Infections drug therapy, Thymus Extracts therapeutic use
Abstract

Recurrent respiratory infections (RRI) are a common occurrence in early childhood. Several investigations report the primary role of environmental factors (as early social mixing and passive smoking) in inducing RRI. In RRI children immunological defects, transient and not typical, have been often observed, but it is reasonable to suppose that they are essentially secondary to infections. Since immune modifications involve essentially cell-mediated immunity, several therapeutical attempts with thymic hormones have been carried out. In the present study the efficacy of thymomodulin was evaluated in a clinical trial in a group of children with RRI. Forty-six children suffering from RRI were enrolled on the basis of RI number in the previous year. Twenty-three children were treated with thymomodulin, twenty-three were not treated and were studied as control group. A significant reduction in the frequency of RI was noted only in treated children. Interleukin-2 production was assayed in all children before and after the trial, but not significant modification was observed in this immunological parameter. This study confirms the effectiveness of treatment with thymomodulin in RRI children, even though immunological background of clinical improvement remains to be elucidated.

Published
1990

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