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180 results on '"La‐Spina, M."'

1. Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials?

Author

Di Cataldo, A., Agodi, A., Balaguer, J., Garaventa, A., Barchitta, M., Segura, V., Bianchi, M., Castel, V., Castellano, A., Cesaro, S., Couselo, J. M., Cruz, O., D’Angelo, P., De Bernardi, B., Donat, J., de Andoin, N. G., Hernandez, M. I., La Spina, M., Lillo, M., Lopez-Almaraz, R., Luksch, R., Mastrangelo, S., Mateos, E., Molina, J., Moscheo, C., Mura, R., Porta, F., Russo, G., Tondo, A., Torrent, M., Vetrella, S., Villegas, J. A., Viscardi, E., Zanazzo, G. A., and Cañete, A.

Published
2017
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9. Complicanze infettive gravi nei pazienti affetti da leucemia linfoblastica acuta (LLA) arruolati nel protocollo AIEOP-BFM ALL 2009: incidenza ed esito. Hematology Reports 2018; 10 (s1): 67

Author

Colombini, A., Brivio, E., Barisone, E., Barone, A., Cellini, M., Kiren, V., La-Spina, M., Mina, T., Muggeo, P., Mura, R., Parasole, R., Putti, M. C., Rizzari, C., Silvestri, D., Vinti, L., Conter, V., and Cesaro, S.

Subjects
leucemia linfoblastica acuta, pediatria, infezioni batteriche, leucemia linfoblastica acuta, pediatria, infezioni batteriche
Published
2018

12. Pediatric intracranial ependymoma: correlating signs and symptoms at recurrence with outcome in the second prospective AIEOP protocol follow-up

Author

Massimino, M, Barretta, F, Modena, P, Giangaspero, F, Chiapparini, L, Erbetta, A, Boschetti, L, Antonelli, M, Ferroli, P, Bertin, D, Pecori, E, Biassoni, V, Garrè, M, Schiavello, E, Sardi, I, Viscardi, E, Scarzello, G, Mascarin, M, Quaglietta, L, Cinalli, G, Genitori, L, Peretta, P, Mussano, A, Barra, S, Mastronuzzi, A, Giussani, C, Marras, C, Balter, R, Bertolini, P, Tornesello, A, La Spina, M, Buttarelli, F, Ruggiero, A, Caldarelli, M, Poggi, G, Gandola, L, Garrè, ML, Marras, CE, Buttarelli, FR, Massimino, M, Barretta, F, Modena, P, Giangaspero, F, Chiapparini, L, Erbetta, A, Boschetti, L, Antonelli, M, Ferroli, P, Bertin, D, Pecori, E, Biassoni, V, Garrè, M, Schiavello, E, Sardi, I, Viscardi, E, Scarzello, G, Mascarin, M, Quaglietta, L, Cinalli, G, Genitori, L, Peretta, P, Mussano, A, Barra, S, Mastronuzzi, A, Giussani, C, Marras, C, Balter, R, Bertolini, P, Tornesello, A, La Spina, M, Buttarelli, F, Ruggiero, A, Caldarelli, M, Poggi, G, Gandola, L, Garrè, ML, Marras, CE, and Buttarelli, FR

Abstract

Purpose: The aims of patients’ radiological surveillance are to: ascertain relapse; apply second-line therapy; accrue patients in phase 1/2 protocols if second-line therapy is not standardized/curative; and assess/treat iatrogenic effects. To lessen the emotional and socioeconomic burdens for patients and families, we ideally need to establish whether scheduled radiological surveillance gives patients a better outcome than waiting for symptoms and signs to appear. Methods: We analyzed a prospective series of 160 newly-diagnosed and treated pediatric/adolescent patients with intracranial ependymoma, comparing patients with recurrent disease identified on scheduled MRI (the RECPT group; 34 cases) with those showing signs/symptoms of recurrent disease (the SYMPPT group; 16 cases). The median follow-up was 67 months. Results: No significant differences emerged between the two groups in terms of gender, age, tumor grade/site, shunting, residual disease, or type of relapse (local, distant, or concomitant). The time to relapse (median 19 months; range 5–104) and the MRI follow-up intervals did not differ between the SYMPPT and RECPT groups. The presence of signs/symptoms was an unfavorable factor for overall survival (OS) after recurrence (5-year OS: 8% vs. 37%, p = 0.001). On multivariable analysis, an adjusted model confirmed a significantly worse OS in the SYMPPT than in the RECPT patients. Conclusions: Symptomatic relapses carried a significantly worse survival for ependymoma patients than recurrences detected by MRI alone. It would therefore be desirable to identify recurrences before symptoms develop. Radiological follow-up should be retained in ependymoma patient surveillance because there is a chance of salvage treatment for relapses found on MRI

Published
2018

20. Incidence of colonization and bloodstream infection with carbapenem-resistant Enterobacteriaceae in children receiving antineoplastic chemotherapy in Italy

Author

Caselli, Desiree, Cesaro, Simone, Fagioli, Franca, Carraro, Francesca, Ziino, Ottavio, Zanazzo, Giulio, Meazza, Cristina, Colombini, Antonella, Castagnola, Elio, Muggeo, P., Mura, Raffaella, Orofino, M. G., Giacchino, M., La Spina, M., Consarino, C., Tucci, F., Barone, A., Cellini, M., Perruccio, K., Bandettini, R., Rondelli, R., De Masi, S., and Aricò, M.

Subjects
0301 basic medicine, Male, Pediatrics, Immunology and Microbiology (all), Bacteremia, Carbapenem-resistant enterobacteriaceae, Drug resistance, Neoplasms, Colonization, Prospective Studies, Child, immunosuppression, Incidence (epidemiology), Mortality rate, Incidence, Enterobacteriaceae Infections, General Medicine, Infectious Diseases, Italy, Child, Preschool, Female, Microbiology (medical), medicine.medical_specialty, Adolescent, 030106 microbiology, Antineoplastic Agents, beta-Lactams, beta-Lactam Resistance, 03 medical and health sciences, Pharmacotherapy, children, Enterobacteriaceae, medicine, cancer, Humans, Preschool, Carbapenemase-producing Enterobacteriaceae, Retrospective Studies, General Immunology and Microbiology, business.industry, Klebsiella pneumoniae carbapenemase, Infant, Newborn, Infant, Retrospective cohort study, Newborn, medicine.disease, Survival Analysis, business, Cancer, Children, Immunosuppression
Abstract

Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology.

Published
2015

21. Protocollo LINES: stato dell'arruolamento in Italia dell'Intermediate Risk

Author

Marino, S., Gigliotti, A. R., Conte, M., Mazzocco, K., Defferrari, R., Pezzolo, A., Sementa, A. R., Castellano, A., D’Angelo, P., De Leonardis, F., Mastrangelo, S., Podda, M., Tondo, A., Cesaro, Simone, Viscardi, E., Bianchi, M., La Spina, M., D’Amico, S., Lo Nigro, L., Russo, G., and Di Cataldo, A.

Subjects
neuroblastoma, neuroblastoma, rischio intermedio, risultati, rischio intermedio, risultati
Published
2015

22. COLONIZZAZIONE ED INFEZIONE DA ENTEROBACTERIACEAE RESISTENTI AI CARBAPENEMICI NEI BAMBINI ITALIANI INTRATTAMENTO CON CHEMIOTERAPIA

Author

Caselli, D., Cesaro, Simone, Fagioli, F., Carraro, F., Ziino, O., Zanazzo, G., Meazza, C., Colombini, A., Muggeo, P. E., Mura, R., Orofino, M. G., Giacchino, M., La Spina, M., Consarino, C., Tucci, F., Barone, A., Cellini, M., Perruccio, K., Bandettini, R., Rondelli, R., De Masi, S., Aricò, M., and Castagnola, E. .

Subjects
antibiotico-resistenza, infezioni batteriche, sepsi, infezioni batteriche, antibiotico-resistenza, sepsi
Published
2015

24. Final results of the second prospective AIEOP protocol for pediatric intracranial ependymoma

Author

Massimino, M, Miceli, R, Giangaspero, F, Boschetti, L, Modena, P, Antonelli, M, Ferroli, P, Bertin, D, Pecori, E, Valentini, L, Biassoni, V, Garrè, M, Schiavello, E, Sardi, I, Cama, A, Viscardi, E, Scarzello, G, Scoccianti, S, Mascarin, M, Quaglietta, L, Cinalli, G, Diletto, B, Genitori, L, Peretta, P, Mussano, A, Buccoliero, A, Calareso, G, Barra, S, Mastronuzzi, A, Giussani, C, Marras, C, Balter, R, Bertolini, P, Giombelli, E, La Spina, M, Buttarelli, F, Pollo, B, Gandola, L, GIUSSANI, CARLO GIORGIO, Gandola, L., Massimino, M, Miceli, R, Giangaspero, F, Boschetti, L, Modena, P, Antonelli, M, Ferroli, P, Bertin, D, Pecori, E, Valentini, L, Biassoni, V, Garrè, M, Schiavello, E, Sardi, I, Cama, A, Viscardi, E, Scarzello, G, Scoccianti, S, Mascarin, M, Quaglietta, L, Cinalli, G, Diletto, B, Genitori, L, Peretta, P, Mussano, A, Buccoliero, A, Calareso, G, Barra, S, Mastronuzzi, A, Giussani, C, Marras, C, Balter, R, Bertolini, P, Giombelli, E, La Spina, M, Buttarelli, F, Pollo, B, Gandola, L, GIUSSANI, CARLO GIORGIO, and Gandola, L.

Abstract

Background This prospective study stratified patients by surgical resection (complete = NED vs incomplete = ED) and centrally reviewed histology (World Health Organization [WHO] grade II vs III). Methods WHO grade II/NED patients received focal radiotherapy (RT) up to 59.4 Gy with 1.8 Gy/day. Grade III/NED received 4 courses of VEC (vincristine, etoposide, cyclophosphamide) after RT. ED patients received 1-4 VEC courses, second-look surgery, and 59.4 Gy followed by an 8-Gy boost in 2 fractions on still measurable residue. NED children aged 1-3 years with grade II tumors could receive 6 VEC courses alone. Results From January 2002 to December 2014, one hundred sixty consecutive children entered the protocol (median age, 4.9 y; males, 100). Follow-up was a median of 67 months. An infratentorial origin was identified in 110 cases. After surgery, 110 patients were NED, and 84 had grade III disease. Multiple resections were performed in 46/160 children (28.8%). A boost was given to 24/40 ED patients achieving progression-free survival (PFS) and overall survival (OS) rates of 58.1% and 68.7%, respectively, in this poor prognosis subgroup. For the whole series, 5-year PFS and OS rates were 65.4% and 81.1%, with no toxic deaths. On multivariable analysis, NED status and grade II were favorable for OS, and for PFS grade II remained favorable. Conclusions In a multicenter collaboration, this trial accrued the highest number of patients published so far, and results are comparable to the best single-institution series. The RT boost, when feasible, seemed effective in improving prognosis. Even after multiple procedures, complete resection confirmed its prognostic strength, along with tumor grade. Biological parameters emerging in this series will be the object of future correlatives and reports.

Published
2016

28. Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials?

Author

Di Cataldo, A., primary, Agodi, A., additional, Balaguer, J., additional, Garaventa, A., additional, Barchitta, M., additional, Segura, V., additional, Bianchi, M., additional, Castel, V., additional, Castellano, A., additional, Cesaro, S., additional, Couselo, J. M., additional, Cruz, O., additional, D’Angelo, P., additional, De Bernardi, B., additional, Donat, J., additional, de Andoin, N. G., additional, Hernandez, M. I., additional, La Spina, M., additional, Lillo, M., additional, Lopez-Almaraz, R., additional, Luksch, R., additional, Mastrangelo, S., additional, Mateos, E., additional, Molina, J., additional, Moscheo, C., additional, Mura, R., additional, Porta, F., additional, Russo, G., additional, Tondo, A., additional, Torrent, M., additional, Vetrella, S., additional, Villegas, J. A., additional, Viscardi, E., additional, Zanazzo, G. A., additional, and Cañete, A., additional

Published
2016
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29. Effect of exposure time on mass‐rearing production of the olive fruit fly parasitoid, <italic>Psyttalia lounsburyi</italic> (Hymenoptera: Braconidae).

Author

La‐Spina, M., Pickett, C., Daane, K. M., Hoelmer, K., Blanchet, A., and Williams, L.

Subjects
*BIOLOGICAL pest control, *BIOLOGICAL control of insects, *OLIVE fly, *PLANT diseases, *PARASITOID behavior
Abstract

Abstract: Classical biological control programmes rely on mass production of high‐quality beneficial insects for subsequent releases into the field. Psyttalia lounsburyi (Silvestri) (Hymenoptera: Braconidae) is a koinobiont larval–pupal endoparasitoid of tephritid flies that is being reared to support a classical biological control programme for olive fruit fly in California. The mass‐rearing system for a P. lounsburyi colony, initiated with insects originally collected in Kenya, was evaluated with the goal of increasing production, while at the same time reducing time requirements for rearing in a quarantine facility. We tested the effect of exposure time of a factitious host Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), on parasitization, adult production, superparasitism, and sex ratio of P. lounsburyi and survival of the host. Parasitization rates were highest (31%) at 3‐ and 4‐hr exposure times, while adult production (i.e., emergence of wasp progeny) was highest (16%) at the 2‐hr exposure time. Superparasitism over the course of the study was 1.5% and did not appear to be a factor affecting parasitoid production. The sex ratio of wasp progeny was male‐biased and did not vary significantly over different exposure times. The rate of stings on host larvae increased with exposure time and was consistent with decreases in pupal eclosion from larvae and emergence rate of adult flies. When compared to current rearing procedures, the 2‐hr exposure time resulted in an overall 2.8‐fold increase in P. lounsburyi production when standardized for time. [ABSTRACT FROM AUTHOR]

Published
2018
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34. Changes in cytokine profile pre- and post-immunosuppression in acquired aplastic anemia

Author

Dufour, C, Ferretti, E, Bagnasco, F, Burlando, O, Lanciotti, M, Ramenghi, Ugo, Saracco, P, Van Lint MT, Longoni, D, Torelli, Gf, Pillon, M, Locasciulli, A, Misuraca, A, La Spina, M, Bacigalupo, A, Pistoia, V, Corcione, A, Svahn, J, and Marrow Failure Study Group of the AIEOP

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, CD3 Complex, aplastic anemia, medicine.medical_treatment, TNF-a, Bone Marrow Cells, Interferon-gamma, Young Adult, IFN-g, Internal medicine, medicine, Humans, Interferon gamma, Aplastic anemia, Child, Cells, Cultured, Interleukin 4, Cell Proliferation, Immunosuppression Therapy, Hematology, immunosuppression, Tumor Necrosis Factor-alpha, business.industry, Bone marrow failure, Anemia, Aplastic, Immunosuppression, Middle Aged, IL4, Flow Cytometry, medicine.disease, Cytokine, Child, Preschool, Immunology, Brief Reports, Female, Tumor necrosis factor alpha, Interleukin-4, business, medicine.drug
Abstract

Cytokine expression assessed by flow cytometry in 53 acquired aplastic anemia patients before and after combined immunosuppression (EBMT WPSAA protocols) showed that CD3(+) marrow cells containing TNF-alpha, IFN-gamma and IL4 were similar in subjects with disease at onset (DO) and responsive to treatment who had more CD3(+)/TNF-alpha(+) and CD 3(+)/IFN-gamma(+) cells than normal controls. In vitro block of TNF-alpha and/or IFN-gamma significantly increased BFU-e over baseline in 28 patients. In responsive to treatment patients only TNF-alpha block significantly incremented colonies over normal controls. Absolute marrow CD3(+)/TNF-alpha(+) and CD3(+)/IFN-gamma(+) cells prospectively tested in a group of 21 subjects declined significantly more in Responders than in Non Responders to immunosuppression at Response Evaluation Time respect to Diagnosis. Both in Responders and in Non Responders these cells remained higher than in normal controls. This study suggests that immunosuppression does not fully clear excess TNF-alpha and IFN-gamma from marrow of patients with good outcome and raises the hypothesis that additional cytokine blockade might be useful in immunosuppression for acquired aplastic anemia.

Published
2009

38. Nivel de daño económico para Aulacorthum solani (Hemiptera, Aphididae) sobre pimiento en invernadero comercial

Author

Hermoso-De-Mendoza, Alfonso, La Spina, M., Marco, F., Tabanera, S., Vinaches, P., Carbonell, Emilio A., and Pérez-Panadés, J.

Subjects
Bajo Segura, U40 Surveying methods, Capsicum annuum, Pérdidas de producción, H10 Pests of plants, Nivel de daño económico, Pulgones, Nivel de daño económico ambiental, Umbral de intervención, Aulacorthum solani, Producción, Densidad de plaga, Invernaderos
Abstract

Entre las especies de pulgones que atacan al pimiento (Capsicum anuum) en las zonas de invernaderos de Valencia y Murcia. la más la más agresiva es Aulacorthum solani (Kaltenbach). Para averiguar su nivel de daño económico se ha realizado un experirnento en un invernadero comercial de pimiento Orlando en el Pilar de la Horadada (en la comarca valenciana del Bajo Segura), consistente en infestar plantas de pimiento con diversos niveles de A. solani y seguir su evolución a lo largo de la temporada 2003-2004, a la vez que semanalmente se iban cosechando, pesando y caracterizando los pimientos. La cantidad máxima de pulgones por hoja de cada nivel de A. solani se ha correlacionado con la pérdida de producción correspondiente, y se ha obtenido así la función ''densidad de plaga/porcentaje de pérdida de producción". A partir de esa función se ha deducido la fórmula del nivel de daño económico. Se ha obtenido el nivel de daño económico que corresponde a los valores usuales en la actualidad de precio y producción de pimiento y de coste y eficacia del tratamiento con el resultado de un nivel tan bajo que implica tratar en cuanto se detecten pulgones si no se quiere que las pérdidas económicas superen el coste del tratamiento.

Published
2006

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