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13 results on '"La Gualana, Francesca"'

3. Absent or suboptimal response to booster dose of COVID-19 vaccine in patients with autoimmune systemic diseases

Author

Ferri, Clodoveo, Gragnani, Laura, Raimondo, Vincenzo, Visentini, Marcella, Giuggioli, Dilia, Lorini, Serena, Foti, Rosario, Cacciapaglia, Fabio, Caminiti, Maurizio, Olivo, Domenico, Cuomo, Giovanna, Pellegrini, Roberta, Pigatto, Erika, Urraro, Teresa, Naclerio, Caterina, Tavoni, Antonio, Puccetti, Lorenzo, Cavazzana, Ilaria, Ruscitti, Piero, Vadacca, Marta, La Gualana, Francesca, Cozzi, Franco, Spinella, Amelia, Visalli, Elisa, Bosco, Ylenia Dal, Amato, Giorgio, Masini, Francesco, Mariano, Giuseppa Pagano, Brittelli, Raffaele, Aiello, Vincenzo, Scorpiniti, Daniela, Rechichi, Giovanni, Varcasia, Giuseppe, Monti, Monica, Elia, Giusy, Franceschini, Franco, Casato, Milvia, Ursini, Francesco, Giacomelli, Roberto, Fallahi, Poupak, Santini, Stefano Angelo, Iannone, Florenzo, Salvarani, Carlo, Zignego, Anna Linda, and Antonelli, Alessandro

Published
2022
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4. COVID-19 vaccine immunogenicity in 16 patients with autoimmune systemic diseases. Lack of both humoral and cellular response to booster dose and ongoing disease modifying therapies

Author

Gragnani, Laura, Visentini, Marcella, Lorini, Serena, La Gualana, Francesca, Santini, Stefano Angelo, Cacciapaglia, Fabio, Tavoni, Antonio, Cuomo, Giovanna, Fallahi, Poupak, Iannone, Florenzo, Antonelli, Alessandro, Casato, Milvia, Zignego, Anna Linda, and Ferri, Clodoveo

Published
2022
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5. Impaired immunogenicity to COVID-19 vaccines in autoimmune systemic diseases. High prevalence of non-response in different patients’ subgroups

Author

Ferri, Clodoveo, Ursini, Francesco, Gragnani, Laura, Raimondo, Vincenzo, Giuggioli, Dilia, Foti, Rosario, Caminiti, Maurizio, Olivo, Domenico, Cuomo, Giovanna, Visentini, Marcella, Cacciapaglia, Fabio, Pellegrini, Roberta, Pigatto, Erika, Urraro, Teresa, Naclerio, Caterina, Tavoni, Antonio, Puccetti, Lorenzo, Varcasia, Giuseppe, Cavazzana, Ilaria, L'Andolina, Massimo, Ruscitti, Piero, Vadacca, Marta, Gigliotti, Pietro, La Gualana, Francesca, Cozzi, Franco, Spinella, Amelia, Visalli, Elisa, Dal Bosco, Ylenia, Amato, Giorgio, Masini, Francesco, Pagano Mariano, Giuseppa, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Rechichi, Giovanni, Ferrari, Tommaso, Monti, Monica, Elia, Giusy, Franceschini, Franco, Meliconi, Riccardo, Casato, Milvia, Iannone, Florenzo, Giacomelli, Roberto, Fallahi, Poupak, Santini, Stefano Angelo, Zignego, Anna Linda, and Antonelli, Alessandro

Published
2021
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6. Competition and stereotypic behavior in Thoroughbred horses: The value of saliva as a diagnostic marker of stress.

Author

Bazzano, Marilena, Marchegiani, Andrea, La Gualana, Francesca, Petriti, Begi, Petrucelli, Marina, Accorroni, Lucrezia, and Laus, Fulvio

Subjects
COMPETITION horses, THOROUGHBRED horse, HORSE training, SHOW horses, BEHAVIORAL assessment
Abstract

Many horses exhibit stereotypies, especially when living in human controlled environments that may prevent horses from satisfying natural needs in terms of feeding, drinking, moving, and socializing. In human medicine, obsessive compulsive disorder and other severe psychiatric disturbances are associated with stereotypic behaviors; salivary biomarkers evaluation is considered a reliable tool for diagnosis of common mental health disorders because saliva collection easy to obtain and noninvasive. In this study, we hypothesized that salivary cortisol concentrations, in addition to alpha-amylase (sAA) and butyrylcholinesterase (BChE) activities, are considered stress biomarkers that may be influenced in horses trained for racing competition with stereotypic behaviors. Saliva at rest condition was obtained from ten non-stereotypic Thoroughbreds horses involved in high-level competition; eleven Thoroughbreds high-level competition horses showing stereotypic behaviors, and five Thoroughbreds leisure non-competition horses. Cortisol was found to be higher in high-level competition non-stereotypic horses and sAA was significantly higher in non-stereotypic leisure horses when compared to horses involved in competition, while BChE did not change between groups. These results may represent the basis for further behavioural evaluation to elucidate how stereotypic horses and horses involved in competition overcome stressful situations. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Opposite Effects of mRNA-Based and Adenovirus-Vectored SARS-CoV-2 Vaccines on Regulatory T Cells: A Pilot Study

Author

La Gualana, Francesca, primary, Maiorca, Francesca, additional, Marrapodi, Ramona, additional, Villani, Francesca, additional, Miglionico, Marzia, additional, Santini, Stefano Angelo, additional, Pulcinelli, Fabio, additional, Gragnani, Laura, additional, Piconese, Silvia, additional, Fiorilli, Massimo, additional, Basili, Stefania, additional, Casato, Milvia, additional, Stefanini, Lucia, additional, and Visentini, Marcella, additional

Published
2023
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9. The Effect of SARS-CoV-2 Vaccination on B-Cell Phenotype in Systemic Sclerosis Patients

Author

Pellicano, Chiara, Colalillo, Amalia, Basile, Valerio, Marino, Mariapaola, Basile, Umberto, La Gualana, Francesca, Mezzaroma, Ivano, Visentini, Marcella, Rosato, Edoardo, Marino, Mariapaola (ORCID:0000-0001-9155-6378), Pellicano, Chiara, Colalillo, Amalia, Basile, Valerio, Marino, Mariapaola, Basile, Umberto, La Gualana, Francesca, Mezzaroma, Ivano, Visentini, Marcella, Rosato, Edoardo, and Marino, Mariapaola (ORCID:0000-0001-9155-6378)

Abstract

Objective: to assess the influence of SARS-CoV-2 mRNA vaccine on B-cell phenotypes in systemic sclerosis (SSc). Methods: peripheral blood B-cell subpopulations were evaluated before (t1) and 3 months (t3) after the second dose of vaccine in 28 SSc patients. Peripheral blood B-cell subpopulations were evaluated in 21 healthy controls (HCs) only at t1. Anti-spike IgG levels were evaluated at t3 in both cohorts. Results: SSc patients presented higher naive, double-negative, and CD21(low) B cells compared to HCs. IgM-memory and switched-memory B cells were lower in SSc patients than HCs. No differences in anti-spike IgG levels after vaccination were observed between SSc patients and HCs. Anti-spike IgG levels after vaccination were lower in SSc patients with increased CD21(low) B cells at baseline compared to SSc patients with normal CD21(low) B cells. A positive correlation was found between IgG levels and naive B cells. A negative linear correlation was shown between IgG levels and IgM-memory, switched-memory, double-negative, and CD21(low) B cells. Conclusions: SARS-CoV-2 mRNA vaccine response is normal in SSc patients not undergoing immunosuppressive therapy. The normal number of naive B cells is a positive marker of antibody response. The increased percentage of CD21(low) B cells represents a negative marker of antibody response.

Published
2022

10. Flares of mixed cryoglobulinaemia vasculitis after vaccination against SARS-CoV-2

Author

Visentini, Marcella, primary, Gragnani, Laura, additional, Santini, Stefano Angelo, additional, Urraro, Teresa, additional, Villa, Annalisa, additional, Monti, Monica, additional, Palladino, Andrea, additional, Petraccia, Luisa, additional, La Gualana, Francesca, additional, Lorini, Serena, additional, Marri, Silvia, additional, Madia, Francesco, additional, Stefanini, Lucia, additional, Basili, Stefania, additional, Fiorilli, Massimo, additional, Ferri, Clodoveo, additional, Zignego, Anna Linda, additional, and Casato, Milvia, additional

Published
2021
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11. Impaired Immunogenicity to COVID-19 Vaccines in Autoimmune Systemic Diseases - High Prevalence of Non-Response in Different Patients’ Subgroups

Author

Ferri, Clodoveo, primary, Ursini, Francesco, additional, Gragnani, Laura, additional, Raimondo, Vincenzo, additional, Giuggioli, Dilia, additional, Foti, Rosario, additional, Caminiti, Maurizio, additional, Olivo, Domenico, additional, Cuomo, Giovanna, additional, Visentini, Marcella, additional, Cacciapaglia, Fabio, additional, Pellegrini, Roberta, additional, Pigatto, Erika, additional, Urraro, Teresa, additional, Naclerio, Caterina, additional, Tavoni, Antonio, additional, Puccetti, Lorenzo, additional, Varcasia, Giuseppe, additional, Cavazzana, Ilaria, additional, L'Andolina, Massimo, additional, Ruscitti, Piero, additional, Vadacca, Marta, additional, Gigliotti, Pietro, additional, La Gualana, Francesca, additional, Cozzi, Franco, additional, Spinella, Amelia, additional, Visalli, Elisa, additional, Dal Bosco, Ylenia, additional, Amato, Giorgio, additional, Masini, Francesco, additional, Pagano Mariano, Giuseppa, additional, Brittelli, Raffaele, additional, Aiello, Vincenzo, additional, Caminiti, Rodolfo, additional, Scorpiniti, Daniela, additional, Rechichi, Giovanni, additional, Ferrari, Tommaso, additional, Monti, Monica, additional, Elia, Giusy, additional, Franceschini, Franco, additional, Meliconi, Riccardo, additional, Casato, Milvia, additional, Iannone, Fiorenzo, additional, Giacomelli, Roberto, additional, Fallahi, Poupak, additional, Santini, Stefano Angelo, additional, Zignego, Anna Linda, additional, and Antonelli, Alessandro, additional

Published
2021
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13. COVID-19 vaccine immunogenicity in 16 patients with autoimmune systemic diseases. Lack of both humoral and cellular response to booster dose and ongoing disease modifying therapies

Author

Laura Gragnani, Marcella Visentini, Serena Lorini, Francesca La Gualana, Stefano Angelo Santini, Fabio Cacciapaglia, Antonio Tavoni, Giovanna Cuomo, Poupak Fallahi, Florenzo Iannone, Alessandro Antonelli, Milvia Casato, Anna Linda Zignego, Clodoveo Ferri, Gragnani, Laura, Visentini, Marcella, Lorini, Serena, La Gualana, Francesca, Santini, Stefano Angelo, Cacciapaglia, Fabio, Tavoni, Antonio, Cuomo, Giovanna, Fallahi, Poupak, Iannone, Florenzo, Antonelli, Alessandro, Casato, Milvia, Zignego, Anna Linda, and Ferri, Clodoveo

Subjects
Booster dose, Autoimmune systemic diseases, T-cell response, Immunology, Immunology and Allergy, Humoral response, Autoimmune systemic disease, Settore BIO/10 - BIOCHIMICA, COVID-19 vaccine
Abstract

Patients with autoimmune systemic diseases (ASDs) represent a frail population during the ongoing COVID-19 pandemic. The vaccination is the major preventive measure; however, a significant number of ASD patients show an impaired production of anti-COVID-19 neutralizing antibodies (NAb), possibly counterbalanced by adequate T-cell response. The present study aimed at evaluating both humoral and cellular response to COVID-19 vaccine booster dose in this particular setting.Serum NAb titer and T-cell response (measuring interferon gamma -IFN-γ- release) were evaluated 3 weeks after the COVID-19 vaccine booster dose, in 17 patients (12 F, mean age 68.8 ± 15.3 SD yrs) with different ASDs, compared to 17 healthy controls (HCs).The analysis excluded one patient reporting symptoms of COVID-19 only after the immunogenicity tests had been performed.The NAb levels were significantly lower in ASD compared to HCs (p 0.0001); moreover, patients showed a higher percentage of negative/sub-optimal humoral response (31% vs 0% of HCs; p = 0.0184).The study of cellular response showed lower levels of IFN-γ for both Ag1 (The impaired immunogenicity to COVID-19 vaccine booster and even more the concomitant lack of both humoral and cellular response might represent a high risk for severe COVID-19, particularly in ASD patients undergoing DMT.These frail subjects should be tightly monitored for their immune protection and prioritized for the fourth dose of COVID-19 vaccine. Moreover, in the occurrence of SARS-CoV2 infection, treatments with specific monoclonal antibodies and/or antivirals may be highly recommendable.

Published
2022

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