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9 results on '"La Gualana, Francesca"'

2. Opposite Effects of mRNA-Based and Adenovirus-Vectored SARS-CoV-2 Vaccines on Regulatory T Cells: A Pilot Study

Author

La Gualana, Francesca, primary, Maiorca, Francesca, additional, Marrapodi, Ramona, additional, Villani, Francesca, additional, Miglionico, Marzia, additional, Santini, Stefano Angelo, additional, Pulcinelli, Fabio, additional, Gragnani, Laura, additional, Piconese, Silvia, additional, Fiorilli, Massimo, additional, Basili, Stefania, additional, Casato, Milvia, additional, Stefanini, Lucia, additional, and Visentini, Marcella, additional

Published
2023
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4. Absent or suboptimal response to booster dose of COVID-19 vaccine in patients with autoimmune systemic diseases

Author

Ferri, Clodoveo, primary, Gragnani, Laura, additional, Raimondo, Vincenzo, additional, Visentini, Marcella, additional, Giuggioli, Dilia, additional, Lorini, Serena, additional, Foti, Rosario, additional, Cacciapaglia, Fabio, additional, Caminiti, Maurizio, additional, Olivo, Domenico, additional, Cuomo, Giovanna, additional, Pellegrini, Roberta, additional, Pigatto, Erika, additional, Urraro, Teresa, additional, Naclerio, Caterina, additional, Tavoni, Antonio, additional, Puccetti, Lorenzo, additional, Cavazzana, Ilaria, additional, Ruscitti, Piero, additional, Vadacca, Marta, additional, La Gualana, Francesca, additional, Cozzi, Franco, additional, Spinella, Amelia, additional, Visalli, Elisa, additional, Bosco, Ylenia Dal, additional, Amato, Giorgio, additional, Masini, Francesco, additional, Mariano, Giuseppa Pagano, additional, Brittelli, Raffaele, additional, Aiello, Vincenzo, additional, Scorpiniti, Daniela, additional, Rechichi, Giovanni, additional, Varcasia, Giuseppe, additional, Monti, Monica, additional, Elia, Giusy, additional, Franceschini, Franco, additional, Casato, Milvia, additional, Ursini, Francesco, additional, Giacomelli, Roberto, additional, Fallahi, Poupak, additional, Santini, Stefano Angelo, additional, Iannone, Florenzo, additional, Salvarani, Carlo, additional, Zignego, Anna Linda, additional, and Antonelli, Alessandro, additional

Published
2022
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5. COVID-19 vaccine immunogenicity in 16 patients with autoimmune systemic diseases. Lack of both humoral and cellular response to booster dose and ongoing disease modifying therapies

Author

Gragnani, Laura, primary, Visentini, Marcella, additional, Lorini, Serena, additional, La Gualana, Francesca, additional, Santini, Stefano Angelo, additional, Cacciapaglia, Fabio, additional, Tavoni, Antonio, additional, Cuomo, Giovanna, additional, Fallahi, Poupak, additional, Iannone, Florenzo, additional, Antonelli, Alessandro, additional, Casato, Milvia, additional, Zignego, Anna Linda, additional, and Ferri, Clodoveo, additional

Published
2022
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6. Impaired immunogenicity to COVID-19 vaccines in autoimmune systemic diseases. High prevalence of non-response in different patients’ subgroups

Author

Ferri, Clodoveo, primary, Ursini, Francesco, additional, Gragnani, Laura, additional, Raimondo, Vincenzo, additional, Giuggioli, Dilia, additional, Foti, Rosario, additional, Caminiti, Maurizio, additional, Olivo, Domenico, additional, Cuomo, Giovanna, additional, Visentini, Marcella, additional, Cacciapaglia, Fabio, additional, Pellegrini, Roberta, additional, Pigatto, Erika, additional, Urraro, Teresa, additional, Naclerio, Caterina, additional, Tavoni, Antonio, additional, Puccetti, Lorenzo, additional, Varcasia, Giuseppe, additional, Cavazzana, Ilaria, additional, L'Andolina, Massimo, additional, Ruscitti, Piero, additional, Vadacca, Marta, additional, Gigliotti, Pietro, additional, La Gualana, Francesca, additional, Cozzi, Franco, additional, Spinella, Amelia, additional, Visalli, Elisa, additional, Dal Bosco, Ylenia, additional, Amato, Giorgio, additional, Masini, Francesco, additional, Pagano Mariano, Giuseppa, additional, Brittelli, Raffaele, additional, Aiello, Vincenzo, additional, Caminiti, Rodolfo, additional, Scorpiniti, Daniela, additional, Rechichi, Giovanni, additional, Ferrari, Tommaso, additional, Monti, Monica, additional, Elia, Giusy, additional, Franceschini, Franco, additional, Meliconi, Riccardo, additional, Casato, Milvia, additional, Iannone, Florenzo, additional, Giacomelli, Roberto, additional, Fallahi, Poupak, additional, Santini, Stefano Angelo, additional, Zignego, Anna Linda, additional, and Antonelli, Alessandro, additional

Published
2021
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7. Flares of mixed cryoglobulinaemia vasculitis after vaccination against SARS-CoV-2

Author

Visentini, Marcella, primary, Gragnani, Laura, additional, Santini, Stefano Angelo, additional, Urraro, Teresa, additional, Villa, Annalisa, additional, Monti, Monica, additional, Palladino, Andrea, additional, Petraccia, Luisa, additional, La Gualana, Francesca, additional, Lorini, Serena, additional, Marri, Silvia, additional, Madia, Francesco, additional, Stefanini, Lucia, additional, Basili, Stefania, additional, Fiorilli, Massimo, additional, Ferri, Clodoveo, additional, Zignego, Anna Linda, additional, and Casato, Milvia, additional

Published
2021
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9. COVID-19 vaccine immunogenicity in 16 patients with autoimmune systemic diseases. Lack of both humoral and cellular response to booster dose and ongoing disease modifying therapies

Author

Laura Gragnani, Marcella Visentini, Serena Lorini, Francesca La Gualana, Stefano Angelo Santini, Fabio Cacciapaglia, Antonio Tavoni, Giovanna Cuomo, Poupak Fallahi, Florenzo Iannone, Alessandro Antonelli, Milvia Casato, Anna Linda Zignego, Clodoveo Ferri, Gragnani, Laura, Visentini, Marcella, Lorini, Serena, La Gualana, Francesca, Santini, Stefano Angelo, Cacciapaglia, Fabio, Tavoni, Antonio, Cuomo, Giovanna, Fallahi, Poupak, Iannone, Florenzo, Antonelli, Alessandro, Casato, Milvia, Zignego, Anna Linda, and Ferri, Clodoveo

Subjects
Booster dose, Autoimmune systemic diseases, T-cell response, Immunology, Immunology and Allergy, Humoral response, Autoimmune systemic disease, Settore BIO/10 - BIOCHIMICA, COVID-19 vaccine
Abstract

Patients with autoimmune systemic diseases (ASDs) represent a frail population during the ongoing COVID-19 pandemic. The vaccination is the major preventive measure; however, a significant number of ASD patients show an impaired production of anti-COVID-19 neutralizing antibodies (NAb), possibly counterbalanced by adequate T-cell response. The present study aimed at evaluating both humoral and cellular response to COVID-19 vaccine booster dose in this particular setting.Serum NAb titer and T-cell response (measuring interferon gamma -IFN-γ- release) were evaluated 3 weeks after the COVID-19 vaccine booster dose, in 17 patients (12 F, mean age 68.8 ± 15.3 SD yrs) with different ASDs, compared to 17 healthy controls (HCs).The analysis excluded one patient reporting symptoms of COVID-19 only after the immunogenicity tests had been performed.The NAb levels were significantly lower in ASD compared to HCs (p 0.0001); moreover, patients showed a higher percentage of negative/sub-optimal humoral response (31% vs 0% of HCs; p = 0.0184).The study of cellular response showed lower levels of IFN-γ for both Ag1 (The impaired immunogenicity to COVID-19 vaccine booster and even more the concomitant lack of both humoral and cellular response might represent a high risk for severe COVID-19, particularly in ASD patients undergoing DMT.These frail subjects should be tightly monitored for their immune protection and prioritized for the fourth dose of COVID-19 vaccine. Moreover, in the occurrence of SARS-CoV2 infection, treatments with specific monoclonal antibodies and/or antivirals may be highly recommendable.

Published
2022

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