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1. POS0875 DEFINING THE THRESHOLD OF NORMALITY IN MUSCULOSKELETAL ULTRASOUND; AN OMERACT ULTRASOUND STUDY

Author

Sahbudin, I., primary, Trickey, J., additional, Gouze, H., additional, Stoenoiu, M. S., additional, Filippou, G., additional, Sakellariou, G., additional, Maruseac, M., additional, Wittoek, R., additional, Carron, P., additional, Tinazzi, I., additional, Iagnocco, A., additional, Serban, T., additional, Azzolin, I., additional, Terslev, L., additional, Ammitzbøll-Danielsen, M., additional, Nyhuus Bendix Rasch, M., additional, Hauge, E. M., additional, Hammer, H. B., additional, Milchert, M., additional, Fliciński, J., additional, Mandl, P., additional, Borst, C., additional, Fodor, D., additional, Vreju, F. A., additional, Karalilova, R., additional, Naredo, E., additional, Sifuentes-Cantú, C., additional, La Paglia, G. M. C., additional, Pineda, C., additional, Gutierrez, M., additional, Leon, G., additional, Reátegui-Sokolova, C., additional, Mortada, M. A., additional, Suzuki, T., additional, Ikeda, K., additional, Ciurtin, C., additional, Kortekaas, M., additional, Ohrndorf, S., additional, Keen, H., additional, Bruyn, G., additional, Filer, A., additional, and D’agostino, M. A., additional

Published
2024
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6. Italian recommendations for influenza and pneumococcal vaccination in adult patients with autoimmune rheumatic diseases

Author

Guerrini, G., Franzetti, F., Giacomelli, R., Meroni, L., Riva, A., Scirè, C. A., Scrivo, R., Tavio, M., Agostinone, A., Airò, P., Atzeni, F., Bartalesi, F., Bazzichi, L., Berardicurti, O., Cassola, G., antonella castagna, Castelli, F., Cattelan, A., Citriniti, G., Cristini, F., Rosa, F., Fracassi, E., Galloway, J., La Paglia, G. M. C., Moioli, M. C., Ripamonti, D., Saracino, A., Tani, C., Tascini, C., Tieghi, T., Tinelli, M., Zabotti, A., Sarzi-Puttini, P., Galli, M., Guerrini, G, Franzetti, F, Giacomelli, R, Meroni, L, Riva, A, Scire, C, Scrivo, R, Tavio, M, Agostinone, A, Airo, P, Atzeni, F, Bartalesi, F, Bazzichi, L, Berardicurti, O, Cassola, G, Castagna, A, Castelli, F, Cattelan, A, Citriniti, G, Cristini, F, De Rosa, F, Fracassi, E, Galloway, J, La Paglia, G, Moioli, M, Ripamonti, D, Saracino, A, Tani, C, Tascini, C, Tieghi, T, Tinelli, M, Zabotti, A, Sarzi-Puttini, P, Galli, M, Guerrini, Giulio, Franzetti, Fabio, Giacomelli, Roberto, Meroni, Luca, Riva, Agostino, Scirè, Carlo Alberto, Scrivo, Rossana, Tavio, Marcello, Agostinone, Adriana, Airò, Paolo, Atzeni, Fabiola, Bartalesi, Filippo, Bazzichi, Laura, Berardicurti, Onorina, Cassola, Giovanni, Castagna, Antonella, Castelli, Francesco, Cattelan, Annamaria, Citriniti, Giorgia, Cristini, Francesco, De Rosa, Francesco, Fracassi, Elena, Galloway, Jame, La Paglia, Giuliana Maria Concetta, Moioli, Maria Cristina, Ripamonti, Diego, Saracino, Annalisa, Tani, Chiara, Tascini, Carlo, Tieghi, Tiziana, Tinelli, Marco, Zabotti, Alen, Sarzi-Puttini, Piercarlo, and Galli, Massimo

Subjects
Adult, Male, pneumococcal vaccine, Consensus, infuenza vaccine, Immunology, vaccination, autoimmune disease, NO, recommendations, influenza vaccination, pneumococcal vaccination, autoimmune rheumatic diseases, Autoimmune Diseases, Pneumococcal Vaccines, Rheumatology, Rheumatic Diseases, Influenza, Human, Pneumonia, Staphylococcal, Immunology and Allergy, Humans, disease-modifying anti-rheumatic drugs, Evidence-Based Medicine, Vaccination, Pneumonia, Influenza, disease-modifying anti-rheumatic drugs, autoimmune rheumatic diseases, infuenza vaccine, pneumococcal vaccine, Italy, Influenza Vaccines, Staphylococcal, Female, Immunosuppressive Agents, Human
Abstract

OBJECTIVES: To provide evidence-based recommendations for vaccination against influenza virus and S. pneumoniae in patients with autoimmune rheumatic diseases (ARDs). METHODS: A Consensus Committee including physicians with expertise in rheumatic and infectious diseases was established by two Italian scientific societies, Società Italiana di Reumatologia (SIR) and Società Italiana di Malattie Infettive e Tropicali (SIMIT). The experts were invited to develop evidence-based recommendations concerning vaccinations in ARDs patients, based on their clinical status before and after undergoing immunosuppressive treatments. Key clinical questions were formulated for the systematic literature reviews, based on the clinical pathway. A search was made in Medline (via PubMed) according to the original MeSH strategy from October 2009 and a keyword strategy from January 2016 up to December 2017, updating existing EULAR recommendations. Specific recommendations were separately voted and scored from 0 (no agreement with) to 100 (maximal agreement) and supporting evidence graded. The mean and standard deviation of the scores were calculated to determine the level of agreement among the experts' panel for each recommendation. Total cumulative agreement ≥70 defined consensus for each statement. RESULTS: Nine recommendations, based on 6 key clinical questions addressed by the expert committee, were proposed. The aim of this work is to integrate the 2011 EULAR recommendations on vaccination against influenza and S. pneumoniae in ARDs patients. An implementation plan was proposed to improve the vaccination status of these patients and their safety during immunosuppressive treatments. CONCLUSIONS: Influenza and pneumococcus vaccinations are effective and safe in patients with ARDs. More efforts should be made to translate the accumulated evidence into practice.

Published
2019

7. Ultrasonography in psoriatic arthritis: which sites should we scan?

Author

Zabotti A., Piga M., Canzoni M., Sakellariou G., Iagnocco A., Scire C. A., Adinolfi A., Azzolin I., Bandinelli F., Batticciotto A., Boffini N., Bortoluzzi A., Carrara G., Cavatorta F. P., Cagnotto G., Caprioli M., Colaci M., De Lucia O., Delle Sedie A., Denaro V., Di Matteo A., Di Sabatino V., Epis O. M., Hoxha A., Farina I., Germano G., Filippou G., Filippucci E., Focherini M. C., Gabba A., Idolazzi L., La Paglia G. M. C., Luccioli F., Macchioni P., Magnani M., Massarotti M., Mastaglio C., Navarini L., Parisi S., Diamanti A. P., Picerno V., Piras M., Porta F., Possemato N., Prevete I., Raffeiner B., Ramonda R., Ravagnani V., Rossi D., Rossi S., Scolieri P., Santoboni G., Scioscia C., Terenzi R., Tinazzi I., Toscano C., Venditti C., Volpe A., Vukatana G., Zanframundo G., Zabotti, A, Piga, M, Canzoni, M, Sakellariou, G, Iagnocco, A, Scire, C, Adinolfi, A, Azzolin, I, Bandinelli, F, Batticciotto, A, Boffini, N, Bortoluzzi, A, Carrara, G, Cavatorta, F, Cagnotto, G, Caprioli, M, Colaci, M, De Lucia, O, Delle Sedie, A, Denaro, V, Di Matteo, A, Di Sabatino, V, Epis, O, Hoxha, A, Farina, I, Germano, G, Filippou, G, Filippucci, E, Focherini, M, Gabba, A, Idolazzi, L, La Paglia, G, Luccioli, F, Macchioni, P, Magnani, M, Massarotti, M, Mastaglio, C, Navarini, L, Parisi, S, Diamanti, A, Picerno, V, Piras, M, Porta, F, Possemato, N, Prevete, I, Raffeiner, B, Ramonda, R, Ravagnani, V, Rossi, D, Rossi, S, Scolieri, P, Santoboni, G, Scioscia, C, Terenzi, R, Tinazzi, I, Toscano, C, Venditti, C, Volpe, A, Vukatana, G, and Zanframundo, G

Subjects
Genetics and Molecular Biology (all), medicine.medical_specialty, Immunology, Arthritis, Physical examination, outcomes research, psoriatic arthritis, ultrasonography, rheumatology, immunology and allergy, immunology, biochemistry, genetics and molecular biology (all), Disease, Biochemistry, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Rheumatology, Immunology and Allergy, Biochemistry, Genetics and Molecular Biology (all), NO, Tendons, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Prospective cohort study, 030203 arthritis & rheumatology, medicine.diagnostic_test, business.industry, outcomes research, psoriatic arthritis, ultrasonography, Arthritis, Psoriatic, Bursa, Synovial, medicine.disease, Joints, Observational study, Differential diagnosis, business
Abstract

In psoriatic arthritis (PsA), ultrasonography (US) plays a growing role in the differential diagnosis and in monitoring treatment response.1 PsA is a heterogeneous disease with different domains and peculiar sites involved.2 Therefore, a dedicated US composite score is needed to monitor disease activity and to identify structural damage progression. A recently published Systematic Literature Review (SLR) identified only two US scores specifically developed for PsA (ie, 5TPD and PsA-Son) and, although these had a good sensitivity to detect inflammation and a good feasibility, they have not been validated in other series.1 3 4 Recently, the Study Group for US of the Italian Society of Rheumatology promoted the Ultrasound in PSoriatic Arthritis TREAtMent (UPSTREAM) study (registered at ClinicalTrial.gov, NCT03330769). UPSTREAM is a multicentre observational prospective cohort study and it represents the first …

Published
2018

10. Rilievi diagnostico-differenziali nell'eczema da contatto

Author

Palminteri, G, Ferruzza, A, La Paglia, G, Totaro, S, VERSO, Maria Gabriella, Giuseppe Palminteri, Raffaele Scerrato, Antonino Coppola, Palminteri, G, Ferruzza, A, La Paglia, G, Totaro, S, and Verso, MG

Subjects
Settore MED/44 - Medicina Del Lavoro, ezema allergico da contatto, eczema professionale, patch-test
Published
2012

13. Sicurezza nei luoghi di lavoro

Author

GRASSO G., LA PAGLIA G., TUZZOLINO S., TORREGROSSA, Maria Valeria, and GRASSO G., LA PAGLIA G., TORREGROSSA M.V., TUZZOLINO S.

Subjects
sicurezza, lavoro, Settore MED/42 - Igiene Generale E Applicata
Published
1999

15. [Shift-work seniority increases the severity of sleep disorders. Comparison of different categories of shift-workers]

Author

Sergio Garbarino, Mascialino B, De Carli F, La Paglia G, Mantineo G, Nobili L, and Ferrillo F

Subjects
Adult, Male, Time Factors, Sleep Disorders, Circadian Rhythm, Work Schedule Tolerance, Humans, Female, Severity of Illness Index
Abstract

Shift-work disrupts the sleep-wake cycle and could bring about sleep disorders and excessive daytime sleepiness. We studied two samples of shift-workers, a group of 178 nurses and one of 174 police officers, all working in the town of Palermo (Italy); their answers to a sleep disorder questionnaire were scored and added in order to create a Sleep Disorder Score (SDS). The SDS cut-off value, discrimining pathological values from physiological ones, was settled a-priori. In both groups SDS did not depend on sex, age, weight, height nor on working seniority, but it increased non linearly (cubic form) with shift-work seniority. In nurses this mathematical description of SDS exceeded the cut-off value after 15 years of shift-work seniority; in police officers it settled asymptotically under the critical value. This could be ascribable both to the different composition in sex of the two samples (nurses: 49% F-51% M vs. police officers: 6% F-94% M) both to the self-selection process that seems to undergo police officers (nurses do not leave shift-work because of salary incentives).

Published
2004

23. One year in review 2015: Idiopathic inflammatory myopathies

Author

Simone Barsotti, Terenzi, R., La Paglia, G. M. C., Bellucci, E., Baldini, C., and Neri, R.

Subjects
Myositis, Autoimmunity, Skeletal, Treatment Outcome, Predictive Value of Tests, Antirheumatic Agents, Muscle, Animals, Humans, Immunologic Factors, Inflammation Mediators, Muscle, Skeletal, Signal Transduction
Abstract

Idiopathic inflammatory myopathies (IIM) are a group of rare acquired muscle diseases that mainly affect skeletal muscles. Recently, novel insights into the pathogenesis, diagnosis and treatment of these complex diseases have been provided. Herewith we provided an overview of the most significant literature contributions published over the year.

33. Randomized Trial of Hymovis® versus Synvisc® on Matrix Metalloproteinases in Knee Osteoarthritis.

Author

Falcinelli, E., Giordan, N., Luccioli, F., Piselli, E., La Paglia, G. M. C., Momi, S., Mirabelli, G., Petito, E., Alunno, A., Gresele, P., and Gerli, R.

Subjects
*OSTEOARTHRITIS treatment, *CYTOKINES, *HYALURONIC acid, *INTRA-articular injections, *INTERLEUKINS, *KNEE diseases, *LYMPHOCYTES, *HEALTH outcome assessment, *QUESTIONNAIRES, *SYNOVIAL fluid, *RANDOMIZED controlled trials, *VISUAL analog scale, *DESCRIPTIVE statistics, *MATRIX metalloproteinases
Abstract

Background. This study aims to evaluate the effects of HYADD 4-G, a not chemically cross-linked HA (Hyaluronic Acid) derivative, and hylan G-F 20, a cross-linked HA product, on synovial matrix metalloproteinases and cytokines in patients suffering from knee osteoarthritis. Methods. 31 patients were randomized to receive HYADD 4-G or hylan G-F 20. Synovial fluid was collected before and one week after the first injection. Activity of MMP-3, MMP-2, MMP-13, IL-6 and other cytokines were measured. Changes in synovial fluid neutrophils and lymphocytes were analyzed. The VAS, the WOMAC questionnaire, and a Physician Global Assessment (PhGA VAS) were recorded. Results. A trend towards a greater decrease in MMP-3 activity was observed in the Hymovis® group. Active MMP-2 and MMP-13 decreased in both groups. IL-6 levels also decreased significantly in both groups. Median change in neutrophils from baseline was significantly different between the treatment groups. No differences between the treatment groups were observed for the WOMAC, VAS and PhGA VAS scores. No serious adverse events were reported. Conclusions. These findings demonstrate that intra-articular HA injections in patients with knee osteoarthritis tend to protect cartilage structural integrity reducing the activity of key proteolytic enzymes implicated in cartilage degradation as well as inflammatory mediators. [ABSTRACT FROM AUTHOR]

Published
2020
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35. La valutazione del rischiio VOCs in un laboratorio di chimica universitario

Author

CRISCIMANNA, Amalia, POLISANO, Angelino, FIORDISPINA, Morena, PROVENZANI, Ambra, LACCA, Guido, LA PAGLIA, Gesualdo, Criscimanna, A, Polisano, A, Fiordispina, M, Provenzani, A, Lacca, G, and La Paglia, G

Subjects
Settore MED/44 - Medicina Del Lavoro, indoor, VOCs, valutazione dei rischi
Published
2010

36. Effetto di campi elettromagnetici sugli organismi: studio clinico-osservazionale

Author

CRISCIMANNA, Amalia, BASTIANINI, Sabrina, FIORDISPINA, Morena, LACCA, Guido, LA PAGLIA, Gesualdo, Sorrentino, S, Criscimanna, A, Bastianini, S, Fiordispina, M, Sorrentino, S, Lacca, G, and La Paglia, G

Subjects
Settore MED/44 - Medicina Del Lavoro, Campi elettromagnetici, D.Lgs. 81/08, questionario neurocomportamentale
Published
2010

42. Piano di evacuazione

Author

LA PAGLIA, Gesualdo, TORREGROSSA, Vittoria, MAIORANA C, GARBO D, GIULIANO V., LA PAGLIA G, TORREGROSSA V, MAIORANA C, GARBO D, and GIULIANO V

Published
2006

44. Sicurezza e salute nell'Ateneo

Author

LA PAGLIA, Gesualdo, CICUTA, Rosa Anna, POLISANO, Angelino, QUARTARARO, Michele, RICHIUSA, Gandolfo, PIGNATO A, LA PAGLIA G, CICUTA RA, PIGNATO A, POLISANO A, QUARTARARO M, and RICHIUSA G

Published
2005

46. Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study.

Author

Trickey J, Sahbudin I, Ammitzbøll-Danielsen M, Azzolin I, Borst C, Bortoluzzi A, Bruyn GA, Carron P, Ciurtin C, Filippou G, Fliciński J, Fodor D, Gouze H, Gutierrez M, Hammer HB, Hauge EM, Iagnocco A, Ikeda K, Karalilova R, Keen HI, Kortekaas M, La Paglia G, Leon G, Mandl P, Maruseac M, Milchert M, Mortada MA, Naredo E, Ohrndorf S, Pineda C, Rasch MNB, Reátegui-Sokolova C, Sakellariou G, Serban T, Sifuentes-Cantú CA, Stoenoiu MS, Suzuki T, Terslev L, Tinazzi I, Vreju FA, Wittoek R, D'Agostino MA, and Filer A

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Healthy Volunteers, Humans, Hypertrophy diagnostic imaging, Hypertrophy epidemiology, Male, Middle Aged, Prevalence, Tenosynovitis diagnostic imaging, Ultrasonography, Young Adult, Tendons diagnostic imaging, Tendons pathology, Tenosynovitis epidemiology
Abstract

Objectives: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range., Methods: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort., Results: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups., Conclusions: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA., Competing Interests: Competing interests: There are no declared competing interests from authors except the following: CC declared grants from NIHR Versus Arthritis, Lilly sponsored EULAR conference travel, Modern Biosciences payment as DSM committee member, Roche consultancy fee and Novartis sponsored writing of one medical paper. KI declared a Mitsubishi-Tanabe research grant for RA; Abbvie, Eli Lilly, Mitsubishi-Tanabe, Bristol-Myers-Squib and Novartis speaker’s fees; and participation on a DSM board for Abbvie, Eli Lilly and Mitsubishi-Tanabe. RK declared support from Abbvie, Roche, Novartis and UCB with payments for travel to meetings/lectures, presentations, speakers’ bureaus, manuscript writing/educational events., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.)

Published
2022
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47. [Incidence of occupational accident in Sicilian University Hospital].

Author

La Paglia G, Biondo V, Bastianini S, Cascio M, and Imburgia P

Subjects
Humans, Incidence, Italy, Accidents, Occupational statistics & numerical data, Health Personnel, Hospitals, University
Abstract

The evolution of the disease accident has been analysed in a University Hospital in Sicily (approx. 2500 employees/year) for the time period between 2002 and 2006. The industrial injuries index has shown a swing in course (from a value of 3.80% in 2002 to 5.17% in 2003 to 4.49% in 2004), affecting the categories of nurses and health social workers most. The phenomenon shows a constant course within the same period for medical staff, technical assistants and administrative staff. Biological risk industrial injuries have the highest frequency compared to all others (62.5% in 2002 down to 42.3% in 2006). The most interesting datum is the relative scarce entity of the phenomenon when compared to other similar hospital situations and the progressive reduction of biological risk incidents.

Published
2007

48. ["Barber's hair sinus": new clinical observation].

Author

Biondo V, Bastianini S, Cassarà V, Baio T, Cutuli P, Imburgia P, and La Paglia G

Subjects
Humans, Male, Middle Aged, Barbering, Granuloma, Foreign-Body diagnosis, Granuloma, Foreign-Body etiology, Granuloma, Foreign-Body therapy, Hair, Hand, Occupational Diseases diagnosis, Occupational Diseases etiology, Occupational Diseases therapy, Pilonidal Sinus diagnosis, Pilonidal Sinus etiology, Pilonidal Sinus therapy
Abstract

The AA describe an unusual case of pilonidal sinus in a barber. The clinical analysis showed the presence, in all digital spaces, of erythemateous areas irregularly infiltrated by small fistular tracts and a keratinization area. In the first interdigital space of the left hand, the discharge of a bristle from the apex of a papule was also visibly evident. The histological examination showed the presence of a foreign body granuloma, with giant cells, lymphocyte and plasma cells, centered on a bristle fragment immersed in a collagenous matrix with abundant keratine, skin thickening and fibrous dermis. Using a probe, it was possible to follow the fistular path and obtain the discharge of several hair fragments, conglutinated by corneous scales, but it was not possible to achieve clinical cure of the lesion. The solution to the problem therefore required surgical therapy.

Published
2007

49. [Usefulness of HbCO level determination in chronic exposure to low environmental concentrations of CO. Study of a group of exposed workers].

Author

La Paglia G, Di Venti E, Mangione G, Bodanza I, Gullo F, Scelsa D, and Torretta R

Subjects
Adult, Humans, Male, Time Factors, Carbon Monoxide analysis, Carboxyhemoglobin analysis, Environmental Exposure analysis, Occupational Exposure analysis
Abstract

This research is based on consideration that HbCO sampling, routinely effected on environmental physician demand for workers' biological monitoring, has a low significance. To confirm or reject this statement, we considered two population groups: n. 583 exposed workers and n. 334 not exposed subjects as control group. The habit of smoking (either as number of cigarettes or as time elapsed between the drawn and the last smoked cigarette) was obviously considered on both groups. The results have shown that it isn't possible to acknowledge the effect of a low CO occupational pollution by using HbCO haematic sampling. The A.A. affirm that it's due to low pollution level in work place and to wrong praxis of haematic sampling performed after a long time from the end of working turn. The research showed a direct correlation between HbCO level and smoking habit and a strong association between time elapsed from last smoked cigarette and haematic sampling.

Published
2003

50. [Shift-work seniority increases the severity of sleep disorders. Comparison of different categories of shift-workers].

Author

Garbarino S, Mascialino B, De Carli F, La Paglia G, Mantineo G, Nobili L, and Ferrillo F

Subjects
Adult, Female, Humans, Male, Severity of Illness Index, Time Factors, Sleep Disorders, Circadian Rhythm epidemiology, Work Schedule Tolerance
Abstract

Shift-work disrupts the sleep-wake cycle and could bring about sleep disorders and excessive daytime sleepiness. We studied two samples of shift-workers, a group of 178 nurses and one of 174 police officers, all working in the town of Palermo (Italy); their answers to a sleep disorder questionnaire were scored and added in order to create a Sleep Disorder Score (SDS). The SDS cut-off value, discrimining pathological values from physiological ones, was settled a-priori. In both groups SDS did not depend on sex, age, weight, height nor on working seniority, but it increased non linearly (cubic form) with shift-work seniority. In nurses this mathematical description of SDS exceeded the cut-off value after 15 years of shift-work seniority; in police officers it settled asymptotically under the critical value. This could be ascribable both to the different composition in sex of the two samples (nurses: 49% F-51% M vs. police officers: 6% F-94% M) both to the self-selection process that seems to undergo police officers (nurses do not leave shift-work because of salary incentives).

Published
2003

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