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Your search keyword '"Labbe, Kristen E"' showing total 13 results
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13 results on '"Labbe, Kristen E"'

2. KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

Author

Pan, Yuanwang, primary, Han, Han, additional, Hu, Hai, additional, Wang, Hua, additional, Song, Yueqiang, additional, Hao, Yuan, additional, Tong, Xinyuan, additional, Patel, Ayushi S., additional, Misirlioglu, Selim, additional, Tang, Sittinon, additional, Huang, Hsin-Yi, additional, Geng, Ke, additional, Chen, Ting, additional, Karatza, Angeliki, additional, Sherman, Fiona, additional, Labbe, Kristen E., additional, Yang, Fan, additional, Chafitz, Alison, additional, Peng, Chengwei, additional, Guo, Chenchen, additional, Moreira, Andre L., additional, Velcheti, Vamsidhar, additional, Lau, Sally C.M., additional, Sui, Pengfei, additional, Chen, Haiquan, additional, Diehl, J. Alan, additional, Rustgi, Anil K., additional, Bass, Adam J., additional, Poirier, John T., additional, Zhang, Xiaoyang, additional, Ji, Hongbin, additional, Zhang, Hua, additional, and Wong, Kwok-Kin, additional

Published
2023
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3. Nemvaleukin alfa, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer

Author

Pan, Yuanwang, primary, Hao, Yuan, additional, Han, Han, additional, Chen, Ting, additional, Ding, Hailin, additional, Labbe, Kristen E, additional, Shum, Elaine, additional, Guidry, Kayla, additional, Hu, Hai, additional, Sherman, Fiona, additional, Geng, Ke, additional, Stephens, Janaye, additional, Chafitz, Alison, additional, Tang, Sittinon, additional, Huang, Hsin-Yi, additional, Peng, Chengwei, additional, Almonte, Christina, additional, Lopes, Jared E, additional, Losey, Heather C, additional, Winquist, Raymond J, additional, Velcheti, Vamsidhar, additional, Zhang, Hua, additional, and Wong, Kwok-Kin, additional

Published
2022
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6. Response to Cottu, Bozec, Basse, and Paoletti

Author

Zhang, Hua, primary, Han, Han, additional, He, Tianhui, additional, Labbe, Kristen E, additional, Hernandez, Adrian V, additional, Chen, Haiquan, additional, Velcheti, Vamsidhar, additional, Stebbing, Justin, additional, and Wong, Kwok-Kin, additional

Published
2021
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8. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

Author

Zhang, Hua, primary, Christensen, Camilla L., additional, Dries, Ruben, additional, Oser, Matthew G., additional, Deng, Jiehui, additional, Diskin, Brian, additional, Li, Fei, additional, Pan, Yuanwang, additional, Zhang, Xuzhu, additional, Yin, Yandong, additional, Papadopoulos, Eleni, additional, Pyon, Val, additional, Thakurdin, Cassandra, additional, Kwiatkowski, Nicholas, additional, Jani, Kandarp, additional, Rabin, Alexandra R., additional, Castro, Dayanne M., additional, Chen, Ting, additional, Silver, Heather, additional, Huang, Qingyuan, additional, Bulatovic, Mirna, additional, Dowling, Catríona M., additional, Sundberg, Belen, additional, Leggett, Alan, additional, Ranieri, Michela, additional, Han, Han, additional, Li, Shuai, additional, Yang, Annan, additional, Labbe, Kristen E., additional, Almonte, Christina, additional, Sviderskiy, Vladislav O., additional, Quinn, Max, additional, Donaghue, Jack, additional, Wang, Eric S., additional, Zhang, Tinghu, additional, He, Zhixiang, additional, Velcheti, Vamsidhar, additional, Hammerman, Peter S., additional, Freeman, Gordon J., additional, Bonneau, Richard, additional, Kaelin, William G., additional, Sutherland, Kate D., additional, Kersbergen, Ariena, additional, Aguirre, Andrew J., additional, Yuan, Guo-Cheng, additional, Rothenberg, Eli, additional, Miller, George, additional, Gray, Nathanael S., additional, and Wong, Kwok-Kin, additional

Published
2020
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9. Clinical Characteristics and Outcomes of COVID-19-Infected Cancer Patients: A Systematic Review and Meta-Analysis.

Author

Zhang, Hua, Han, Han, He, Tianhui, Labbe, Kristen E, Hernandez, Adrian V, Chen, Haiquan, Velcheti, Vamsidhar, Stebbing, Justin, and Wong, Kwok-Kin

Subjects
COVID-19, TREATMENT effectiveness, CANCER patients, LOGISTIC regression analysis, DEATH rate, INVASIVE candidiasis
Abstract

Background: Previous studies have indicated coronavirus disease 2019 (COVID-19) patients with cancer have a high fatality rate.Methods: We conducted a systematic review of studies that reported fatalities in COVID-19 patients with cancer. A comprehensive meta-analysis that assessed the overall case fatality rate and associated risk factors was performed. Using individual patient data, univariate and multivariable logistic regression analyses were used to estimate odds ratios (OR) for each variable with outcomes.Results: We included 15 studies with 3019 patients, of which 1628 were men; 41.0% were from the United Kingdom and Europe, followed by the United States and Canada (35.7%), and Asia (China, 23.3%). The overall case fatality rate of COVID-19 patients with cancer measured 22.4% (95% confidence interval [CI] = 17.3% to 28.0%). Univariate analysis revealed age (OR = 3.57, 95% CI = 1.80 to 7.06), male sex (OR = 2.10, 95% CI = 1.07 to 4.13), and comorbidity (OR = 2.00, 95% CI = 1.04 to 3.85) were associated with increased risk of severe events (defined as the individuals being admitted to the intensive care unit, or requiring invasive ventilation, or death). In multivariable analysis, only age greater than 65 years (OR = 3.16, 95% CI = 1.45 to 6.88) and being male (OR = 2.29, 95% CI = 1.07 to 4.87) were associated with increased risk of severe events.Conclusions: Our analysis demonstrated that COVID-19 patients with cancer have a higher fatality rate compared with that of COVID-19 patients without cancer. Age and sex appear to be risk factors associated with a poorer prognosis. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Clinical Characteristics and Outcomes of COVID-19-Infected Cancer Patients: A Systematic Review and Meta-Analysis.

Author

Zhang H, Han H, He T, Labbe KE, Hernandez AV, Chen H, Velcheti V, Stebbing J, and Wong KK

Subjects
Asia epidemiology, COVID-19 mortality, COVID-19 virology, Canada epidemiology, Comorbidity, Europe epidemiology, Female, Humans, Male, Neoplasms mortality, Risk Factors, SARS-CoV-2 physiology, Survival Rate, United Kingdom epidemiology, United States epidemiology, COVID-19 epidemiology, Neoplasms epidemiology
Abstract

Background: Previous studies have indicated coronavirus disease 2019 (COVID-19) patients with cancer have a high fatality rate., Methods: We conducted a systematic review of studies that reported fatalities in COVID-19 patients with cancer. A comprehensive meta-analysis that assessed the overall case fatality rate and associated risk factors was performed. Using individual patient data, univariate and multivariable logistic regression analyses were used to estimate odds ratios (OR) for each variable with outcomes., Results: We included 15 studies with 3019 patients, of which 1628 were men; 41.0% were from the United Kingdom and Europe, followed by the United States and Canada (35.7%), and Asia (China, 23.3%). The overall case fatality rate of COVID-19 patients with cancer measured 22.4% (95% confidence interval [CI] = 17.3% to 28.0%). Univariate analysis revealed age (OR = 3.57, 95% CI = 1.80 to 7.06), male sex (OR = 2.10, 95% CI = 1.07 to 4.13), and comorbidity (OR = 2.00, 95% CI = 1.04 to 3.85) were associated with increased risk of severe events (defined as the individuals being admitted to the intensive care unit, or requiring invasive ventilation, or death). In multivariable analysis, only age greater than 65 years (OR = 3.16, 95% CI = 1.45 to 6.88) and being male (OR = 2.29, 95% CI = 1.07 to 4.87) were associated with increased risk of severe events., Conclusions: Our analysis demonstrated that COVID-19 patients with cancer have a higher fatality rate compared with that of COVID-19 patients without cancer. Age and sex appear to be risk factors associated with a poorer prognosis., (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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