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5 results on '"Laboratoire SITI [CHU Rennes]"'

1. Lipo-Bodylift Reconstruction Following Massive Weight Loss: Our Experience with 100 Consecutive Cases

Author

Raphael Carloni, Jérôme Duisit, Damien Bergeat, Yanis Berkane, Nicolas Bertheuil, Silvia Gandolfi, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de chirurgie plastique, Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire SITI [CHU Rennes], Etablissement français du sang [Rennes] (EFS Bretagne)-CHU Pontchaillou [Rennes], CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital privé de l'Estuaire [Le Havre], CHU Rouen, Normandie Université (NU), Cliniques Universitaires Saint-Luc [Bruxelles], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Jonchère, Laurent

Subjects
Adult, medicine.medical_specialty, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, Bodylift, [SDV]Life Sciences [q-bio], medicine.medical_treatment, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030230 surgery, Body Contouring Surgery, Obesity lipobody lift, Body Mass Index, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Lipectomy, Weight loss, Weight Loss, medicine, Humans, Retrospective Studies, 2. Zero hunger, Abdominoplasty, business.industry, Wound dehiscence, medicine.disease, Body Contouring, 3. Good health, Surgery, [SDV] Life Sciences [q-bio], Plastic surgery, Treatment Outcome, Liposuction, Body contouring, Massive weight loss, medicine.symptom, business, Complication, Body mass index
Abstract

International audience; BACKGROUND: We report our experience using the Lipo-Bodylift technique for circumferential lower trunk reconstruction following massive weight loss. METHODS: The procedure combines extensive circular liposuction with circular skin resection immediately under the dermis. We classify lower trunk deformities using three parameters: (1) excess skin (in the horizontal direction, or both horizontally and vertically); (2) the body mass index (BMI); and, (3) skin quality (hyperlaxity or a normal tone). All patients can be divided into four groups, of whom groups I and II are the best candidates for the Lipo-Bodylift procedure. We also describe our perioperative management and patient outcomes, with a focus on postoperative complications. RESULTS: Between January 2015 and January 2020, 100 patients underwent Lipo-Bodylift treatment. The median patient age was 41 years. The median preoperative BMI was 26.3 kg/m(2). The median drainage duration and hospital stay were both 3 days. Of all patients, 30% experienced at least one complication, 2% of which were major. Of the minor complications, 27 patients evidenced wound dehiscence. Only (positive) smoking status was significantly associated with postoperative complications (p

Published
2021

2. Exploring T[FH] subsets involvement in Multiple Sclerosis course

Author

Morille, J., Rodriguez, S., Thomas, P., Garcia, A., Berthelot, L., Nicot, A., Brouard, S., Laplaud, D.A., Michel, L., Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire SITI [CHU Rennes], Etablissement français du sang [Rennes] (EFS Bretagne)-CHU Pontchaillou [Rennes], Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Le Bihan, Sylvie

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2019

3. The Cassini VIMS archive of Titan: From browse products to global infrared color maps

Author

Jason W. Barnes, S. Le Mouélic, Jason M. Soderblom, Benoît Seignovert, Sebastien Rodriguez, Roger N. Clark, Philip D. Nicholson, Robert H. Brown, Thomas Cornet, B. J. Buratti, Jérémie Lasue, V. Pasek, Kevin H. Baines, Christophe Sotin, Laboratoire de Planétologie et Géodynamique [UMR 6112] (LPG), Université d'Angers (UA)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Formation et de Recherche sur les Environnements Méditérranéens (CEFREM), Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Department of Physics [Moscow,USA], University of Idaho [Moscow, USA], Lunar and Planetary Laboratory [Tucson] (LPL), University of Arizona, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), California Institute of Technology (CALTECH), Department of Astronomy [Ithaca], Cornell University [New York], Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Massachusetts Institute of Technology (MIT), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire SITI [CHU Rennes], Etablissement français du sang [Rennes] (EFS Bretagne)-CHU Pontchaillou [Rennes], Université de Perpignan Via Domitia (UPVD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Universität Bern- University of Bern [Bern], Partenaires INRAE, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), DLR Institute of Planetary Research, German Aerospace Center (DLR), US Geological Survey [Denver], United States Geological Survey [Reston] (USGS), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)

Subjects
Brightness, Haze, 010504 meteorology & atmospheric sciences, [PHYS.ASTR.EP]Physics [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Multispectral image, FOS: Physical sciences, 01 natural sciences, law.invention, law, 0103 physical sciences, Radiative transfer, Imaging science, Radar, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Remote sensing, Earth and Planetary Astrophysics (astro-ph.EP), Spectrometer, Pixel, Astronomy and Astrophysics, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Geology, Astrophysics - Earth and Planetary Astrophysics
Abstract

International audience; We have analyzed the complete Visual and Infrared Mapping Spectrometer (VIMS) data archive of Titan. Our objective is to build global surface cartographic products, by combining all the data gathered during the 127 targeted flybys of Titan into synthetic global maps interpolated on a grid at 32 pixels per degree (∼1.4 km/pixel at the equator), in seven infrared spectral atmospheric windows. Multispectral summary images have been computed for each single VIMS cube in order to rapidly identify their scientific content and assess their quality. These summary images are made available to the community on a public website (vims.univ-nantes.fr). The global mapping work faced several challenges due to the strong absorbing and scattering effects of the atmosphere coupled to the changing observing conditions linked to the orbital tour of the Cassini mission. We determined a surface photometric function which accounts for variations in incidence, emergence and phase angles, and which is able to mitigate brightness variations linked to the viewing geometry of the flybys. The atmospheric contribution has been reduced using the subtraction of the methane absorption band wings, considered as proxies for atmospheric haze scattering. We present a new global three color composite map of band ratios (red: 1.59/1.27 µm; green: 2.03/1.27 µm; blue: 1.27/1.08 µm), which has also been empirically corrected from an airmass (the solar photon path length through the atmosphere) dependence. This map provides a detailed global color view of Titan's surface partially corrected from the atmosphere and gives a global insight of the spectral variability, with the equatorial dunes fields appearing in brownish tones, and several occurrences of bluish tones localized in areas such as Sinlap, Menvra and Selk craters. This kind of spectral map can serve as a basis for further regional studies and comparisons with radiative transfer outputs, such as surface albedos, and other additional data sets acquired by the Cassini Radar (RADAR) and Imaging Science Subsystem (ISS) instruments.

Published
2019

4. B cell differentiation is defective in multiple sclerosis patients

Author

Morille, Jérémy, Chesneau, M., Lejeune, F., Garcia, A., Berthelot, L., Nicot, A., Brouard, Sophie, Laplaud, David-Axel, Michel, L., Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pontchaillou [Rennes], Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Novartis, Biogen-Idec, Merck, Bayer Schering, Roche, Medday, Teva, Genzyme Sanofi, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Service de Neurologie [Rennes] = Neurology [Rennes], Laboratoire SITI [CHU Rennes], Etablissement français du sang [Rennes] (EFS Bretagne)-CHU Pontchaillou [Rennes], and Le Bihan, Sylvie

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

5. Molecular Networking for Drug Toxicities Studies: The Case of Hydroxychloroquine in COVID-19 Patients.

Author

Ferron PJ, Le Daré B, Bronsard J, Steichen C, Babina E, Pelletier R, Hauet T, Morel I, Tarte K, Reizine F, Clément B, Fromenty B, and Gicquel T

Subjects
Aged, Antiviral Agents therapeutic use, COVID-19 complications, COVID-19 metabolism, Cell Line, Cell Survival drug effects, Chemical and Drug Induced Liver Injury metabolism, Correlation of Data, Drug-Related Side Effects and Adverse Reactions, Fatty Acids pharmacology, Fatty Liver complications, Fatty Liver metabolism, Female, Humans, Hydroxychloroquine therapeutic use, Linear Models, Male, Metabolic Networks and Pathways, Middle Aged, Obesity complications, Obesity metabolism, Risk Factors, Antiviral Agents adverse effects, Antiviral Agents metabolism, Hydroxychloroquine adverse effects, Hydroxychloroquine metabolism, COVID-19 Drug Treatment
Abstract

Using drugs to treat COVID-19 symptoms may induce adverse effects and modify patient outcomes. These adverse events may be further aggravated in obese patients, who often present different illnesses such as metabolic-associated fatty liver disease. In Rennes University Hospital, several drug such as hydroxychloroquine (HCQ) have been used in the clinical trial HARMONICOV to treat COVID-19 patients, including obese patients. The aim of this study is to determine whether HCQ metabolism and hepatotoxicity are worsened in obese patients using an in vivo/in vitro approach. Liquid chromatography high resolution mass spectrometry in combination with untargeted screening and molecular networking were employed to study drug metabolism in vivo (patient's plasma) and in vitro (HepaRG cells and RPTEC cells). In addition, HepaRG cells model were used to reproduce pathophysiological features of obese patient metabolism, i.e., in the condition of hepatic steatosis. The metabolic signature of HCQ was modified in HepaRG cells cultured under a steatosis condition and a new metabolite was detected (carboxychloroquine). The RPTEC model was found to produce only one metabolite. A higher cytotoxicity of HCQ was observed in HepaRG cells exposed to exogenous fatty acids, while neutral lipid accumulation (steatosis) was further enhanced in these cells. These in vitro data were compared with the biological parameters of 17 COVID-19 patients treated with HCQ included in the HARMONICOV cohort. Overall, our data suggest that steatosis may be a risk factor for altered drug metabolism and possibly toxicity of HCQ.

Published
2021
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