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1. Six Long-Standing Questions about Antibiotic Prophylaxis in Surgery

Author

Sartelli, M. Boermeester, M.A. Cainzos, M. Coccolini, F. de Jonge, S.W. Rasa, K. Dellinger, E.P. McNamara, D.A. Fry, D.E. Cui, Y. Delibegovic, S. Demetrashvili, Z. De Simone, B. Gkiokas, G. Hardcastle, T.C. Itani, K.M.F. Isik, A. Labricciosa, F.M. Lohsiriwat, V. Marwah, S. Pintar, T. Rickard, J. Shelat, V.G. Catena, F. Barie, P.S. and Sartelli, M. Boermeester, M.A. Cainzos, M. Coccolini, F. de Jonge, S.W. Rasa, K. Dellinger, E.P. McNamara, D.A. Fry, D.E. Cui, Y. Delibegovic, S. Demetrashvili, Z. De Simone, B. Gkiokas, G. Hardcastle, T.C. Itani, K.M.F. Isik, A. Labricciosa, F.M. Lohsiriwat, V. Marwah, S. Pintar, T. Rickard, J. Shelat, V.G. Catena, F. Barie, P.S.

Abstract

Surgical site infections (SSIs) are the most common adverse event occurring in surgical patients. Optimal prevention of SSIs requires the bundled integration of a variety of measures before, during, and after surgery. Surgical antibiotic prophylaxis (SAP) is an effective measure for preventing SSIs. It aims to counteract the inevitable introduction of bacteria that colonize skin or mucosa into the surgical site during the intervention. This document aims to guide surgeons in appropriate administration of SAP by addressing six key questions. The expert panel identifies a list of principles in response to these questions that every surgeon around the world should always respect in administering SAP. © 2023 by the authors.

Published
2023

2. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

Author

Sartelli, M., Labricciosa, F.M., Coccolini, F., Coimbra, R., Abu-Zidan, F.M., Ansaloni, L., Al-Hasan, M.N., Ansari, S., Barie, P.S., Caínzos, M.A., Ceresoli, M., Chiarugi, M., Claridge, J.A., Cicuttin, E., Dellinger, E.P., Fry, D.E., Guirao, X., Hardcastle, T.C., Hecker, A., Leppäniemi, A.K., Litvin, A., Marwah, S., Maseda, E., Mazuski, J.E., Memish, Z.A., Kirkpatrick, A.W., Pagani, L., Podda, M., Rasa, H.K., Sakakushev, B.E., Sawyer, R.G., Tumietto, F., Xiao, Y., Aboubreeg, W.F., Adamou, H., Akhmeteli, L., Akin, E., Alberio, M.G., Alconchel, F., Magagi, I.A., Araúz, A.B., Argenio, G., Atanasov, B.C., Atici, S.D., Awad, S.S., Baili, E., Bains, L., Bala, M., Baraket, O., Baral, S., Belskii, V.A., Benboubker, M., Ben-Ishay, O., Bordoni, P., Boumédiène, A., Brisinda, G., Cavazzuti, L., Chandy, S.J., Chiarello, M.M., Cillara, N., Clarizia, G., Cocuz, M.E., Cocuz, I.G., Conti, L., Coppola, R., Cui, Y., Czepiel, J., D'Acapito, F., Damaskos, D., Das, K., Simone, B. De, Delibegovic, S., Demetrashvili, Z., Detanac, D.S., Dhingra, S., Bella, S. Di, Dimitrov, E.N., Dogjani, A., D'Oria, M., Dumitru, I.M., Elmangory, M.M., Enciu, O., Fantoni, M., Filipescu, D., Fleres, F., Foghetti, D., Fransvea, P., Gachabayov, M., Galeiras, R., Gattuso, G., Ghannam, W.M., Ghisetti, V., Giraudo, G., Gonfa, K.B., Gonullu, E., Hamad, Y., Hecker, M., Isik, A., Ismail, N., Ismail, A., Goor, H. van, Maier, R.V., Catena, F., Sartelli, M., Labricciosa, F.M., Coccolini, F., Coimbra, R., Abu-Zidan, F.M., Ansaloni, L., Al-Hasan, M.N., Ansari, S., Barie, P.S., Caínzos, M.A., Ceresoli, M., Chiarugi, M., Claridge, J.A., Cicuttin, E., Dellinger, E.P., Fry, D.E., Guirao, X., Hardcastle, T.C., Hecker, A., Leppäniemi, A.K., Litvin, A., Marwah, S., Maseda, E., Mazuski, J.E., Memish, Z.A., Kirkpatrick, A.W., Pagani, L., Podda, M., Rasa, H.K., Sakakushev, B.E., Sawyer, R.G., Tumietto, F., Xiao, Y., Aboubreeg, W.F., Adamou, H., Akhmeteli, L., Akin, E., Alberio, M.G., Alconchel, F., Magagi, I.A., Araúz, A.B., Argenio, G., Atanasov, B.C., Atici, S.D., Awad, S.S., Baili, E., Bains, L., Bala, M., Baraket, O., Baral, S., Belskii, V.A., Benboubker, M., Ben-Ishay, O., Bordoni, P., Boumédiène, A., Brisinda, G., Cavazzuti, L., Chandy, S.J., Chiarello, M.M., Cillara, N., Clarizia, G., Cocuz, M.E., Cocuz, I.G., Conti, L., Coppola, R., Cui, Y., Czepiel, J., D'Acapito, F., Damaskos, D., Das, K., Simone, B. De, Delibegovic, S., Demetrashvili, Z., Detanac, D.S., Dhingra, S., Bella, S. Di, Dimitrov, E.N., Dogjani, A., D'Oria, M., Dumitru, I.M., Elmangory, M.M., Enciu, O., Fantoni, M., Filipescu, D., Fleres, F., Foghetti, D., Fransvea, P., Gachabayov, M., Galeiras, R., Gattuso, G., Ghannam, W.M., Ghisetti, V., Giraudo, G., Gonfa, K.B., Gonullu, E., Hamad, Y., Hecker, M., Isik, A., Ismail, N., Ismail, A., Goor, H. van, Maier, R.V., and Catena, F.

Abstract

Item does not contain fulltext, BACKGROUND: The objectives of the study were to investigate the organizational characteristics of acute care facilities worldwide in preventing and managing infections in surgery; assess participants' perception regarding infection prevention and control (IPC) measures, antibiotic prescribing practices, and source control; describe awareness about the global burden of antimicrobial resistance (AMR) and IPC measures; and determine the role of the Coronavirus Disease 2019 pandemic on said awareness. METHODS: A cross-sectional web-based survey was conducted contacting 1432 health care workers (HCWs) belonging to a mailing list provided by the Global Alliance for Infections in Surgery. The self-administered questionnaire was developed by a multidisciplinary team. The survey was open from May 22, 2021, and June 22, 2021. Three reminders were sent, after 7, 14, and 21 days. RESULTS: Three hundred four respondents from 72 countries returned a questionnaire, with an overall response rate of 21.2%. Respectively, 90.4% and 68.8% of participants stated their hospital had a multidisciplinary IPC team or a multidisciplinary antimicrobial stewardship team. Local protocols for antimicrobial therapy of surgical infections and protocols for surgical antibiotic prophylaxis were present in 76.6% and 90.8% of hospitals, respectively. In 23.4% and 24.0% of hospitals no surveillance systems for surgical site infections and no monitoring systems of used antimicrobials were implemented. Patient and family involvement in IPC management was considered to be slightly or not important in their hospital by the majority of respondents (65.1%). Awareness of the global burden of AMR among HCWs was considered very important or important by 54.6% of participants. The COVID-19 pandemic was considered by 80.3% of respondents as a very important or important factor in raising HCWs awareness of the IPC programs in their hospital. Based on the survey results, the authors developed 15 statements for sever

Published
2022

3. 2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting

Author

Sartelli, M. Weber, D.G. Kluger, Y. Ansaloni, L. Coccolini, F. Abu-Zidan, F. Augustin, G. Ben-Ishay, O. Biffl, W.L. Bouliaris, K. Catena, R. Ceresoli, M. Chiara, O. Chiarugi, M. Coimbra, R. Cortese, F. Cui, Y. Damaskos, D. De' Angelis, G.L. Delibegovic, S. Demetrashvili, Z. De Simone, B. Di Marzo, F. Di Saverio, S. Duane, T.M. Faro, M.P. Fraga, G.P. Gkiokas, G. Gomes, C.A. Hardcastle, T.C. Hecker, A. Karamarkovic, A. Kashuk, J. Khokha, V. Kirkpatrick, A.W. Kok, K.Y.Y. Inaba, K. Isik, A. Labricciosa, F.M. Latifi, R. Leppäniemi, A. Litvin, A. Mazuski, J.E. Maier, R.V. Marwah, S. McFarlane, M. Moore, E.E. Moore, F.A. Negoi, I. Pagani, L. Rasa, K. Rubio-Perez, I. Sakakushev, B. Sato, N. Sganga, G. Siquini, W. Tarasconi, A. Tolonen, M. Ulrych, J. Zachariah, S.K. Catena, F.

Abstract

Acute colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in the acute setting. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of acute left-sided colonic diverticulitis (ALCD) according to the most recent available literature. The update includes recent changes introduced in the management of ALCD. The new update has been further integrated with advances in acute right-sided colonic diverticulitis (ARCD) that is more common than ALCD in select regions of the world. © 2020 The Author(s).

Published
2020

4. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: A WSES observational study

Author

Sartelli, M. Abu-Zidan, F.M. Labricciosa, F.M. Kluger, Y. Coccolini, F. Ansaloni, L. Leppäniemi, A. Kirkpatrick, A.W. Tolonen, M. Tranà, C. Regimbeau, J.-M. Hardcastle, T. Koshy, R.M. Abbas, A. Aday, U. Adesunkanmi, A.R.K. Ajibade, A. Akhmeteli, L. Akln, E. Akkapulu, N. Alotaibi, A. Altintoprak, F. Anyfantakis, D. Atanasov, B. Augustin, G. Azevedo, C. Bala, M. Balalis, D. Baraket, O. Baral, S. Barkai, O. Beltran, M. Bini, R. Bouliaris, K. Caballero, A.B. Calu, V. Catani, M. Ceresoli, M. Charalampakis, V. Jusoh, A.C. Chiarugi, M. Cillara, N. Cuesta, R.C. Cobuccio, L. Cocorullo, G. Colak, E. Conti, L. Cui, Y. De Simone, B. Delibegovic, S. Demetrashvili, Z. Demetriades, D. Dimova, A. Dogjani, A. Enani, M. Farina, F. Ferrara, F. Foghetti, D. Fontana, T. Fraga, G.P. Gachabayov, M. Gérard, G. Ghnnam, W. Maurel, T.G. Gkiokas, G. Gomes, C.A. Guner, A. Gupta, S. Hecker, A. Hirano, E.S. Hodonou, A. Hutan, M. Ilaschuk, I. Ioannidis, O. Isik, A. Ivakhov, G. Jain, S. Jokubauskas, M. Karamarkovic, A. Kaushik, R. Kenig, J. Khokha, V. Khokha, D. Kim, J.I. Kong, V. Korkolis, D. Kruger, V.F. Kshirsagar, A. Simões, R.L. Lanaia, A. Lasithiotakis, K. Leão, P. Arellano, M.L. Listle, H. Litvin, A. Lizarazu Pérez, A. Lopez-Tomassetti Fernandez, E. Lostoridis, E. Luppi, D. Machain V, G.M. Major, P. Manatakis, D. Reitz, M.M. Marinis, A. Marrelli, D. Martínez-Pérez, A. Marwah, S. McFarlane, M. Mesic, M. Mesina, C. Michalopoulos, N. Misiakos, E. Moreira, F.G. Mouaqit, O. Muhtaroglu, A. Naidoo, N. Negoi, I. Nikitina, Z. Nikolopoulos, I. Nita, G.-E. Occhionorelli, S. Olaoye, I. Ordoñez, C.A. Ozkan, Z. Pal, A. Palini, G.M. Papageorgiou, K. Papagoras, D. Pata, F. Pȩdziwiatr, M. Pereira, J. Pereira Junior, G.A. Perrone, G. Pintar, T. Pisarska, M. Plehutsa, O. Podda, M. Poillucci, G. Quiodettis, M. Rahim, T. Rios-Cruz, D. Rodrigues, G. Rozov, D. Sakakushev, B. Sall, I. Sazhin, A. Semião, M. Sharda, T. Shelat, V. Sinibaldi, G. Skicko, D. Skrovina, M. Stamatiou, D. Stella, M. Strzałka, M. Sydorchuk, R and Sartelli, M. Abu-Zidan, F.M. Labricciosa, F.M. Kluger, Y. Coccolini, F. Ansaloni, L. Leppäniemi, A. Kirkpatrick, A.W. Tolonen, M. Tranà, C. Regimbeau, J.-M. Hardcastle, T. Koshy, R.M. Abbas, A. Aday, U. Adesunkanmi, A.R.K. Ajibade, A. Akhmeteli, L. Akln, E. Akkapulu, N. Alotaibi, A. Altintoprak, F. Anyfantakis, D. Atanasov, B. Augustin, G. Azevedo, C. Bala, M. Balalis, D. Baraket, O. Baral, S. Barkai, O. Beltran, M. Bini, R. Bouliaris, K. Caballero, A.B. Calu, V. Catani, M. Ceresoli, M. Charalampakis, V. Jusoh, A.C. Chiarugi, M. Cillara, N. Cuesta, R.C. Cobuccio, L. Cocorullo, G. Colak, E. Conti, L. Cui, Y. De Simone, B. Delibegovic, S. Demetrashvili, Z. Demetriades, D. Dimova, A. Dogjani, A. Enani, M. Farina, F. Ferrara, F. Foghetti, D. Fontana, T. Fraga, G.P. Gachabayov, M. Gérard, G. Ghnnam, W. Maurel, T.G. Gkiokas, G. Gomes, C.A. Guner, A. Gupta, S. Hecker, A. Hirano, E.S. Hodonou, A. Hutan, M. Ilaschuk, I. Ioannidis, O. Isik, A. Ivakhov, G. Jain, S. Jokubauskas, M. Karamarkovic, A. Kaushik, R. Kenig, J. Khokha, V. Khokha, D. Kim, J.I. Kong, V. Korkolis, D. Kruger, V.F. Kshirsagar, A. Simões, R.L. Lanaia, A. Lasithiotakis, K. Leão, P. Arellano, M.L. Listle, H. Litvin, A. Lizarazu Pérez, A. Lopez-Tomassetti Fernandez, E. Lostoridis, E. Luppi, D. Machain V, G.M. Major, P. Manatakis, D. Reitz, M.M. Marinis, A. Marrelli, D. Martínez-Pérez, A. Marwah, S. McFarlane, M. Mesic, M. Mesina, C. Michalopoulos, N. Misiakos, E. Moreira, F.G. Mouaqit, O. Muhtaroglu, A. Naidoo, N. Negoi, I. Nikitina, Z. Nikolopoulos, I. Nita, G.-E. Occhionorelli, S. Olaoye, I. Ordoñez, C.A. Ozkan, Z. Pal, A. Palini, G.M. Papageorgiou, K. Papagoras, D. Pata, F. Pȩdziwiatr, M. Pereira, J. Pereira Junior, G.A. Perrone, G. Pintar, T. Pisarska, M. Plehutsa, O. Podda, M. Poillucci, G. Quiodettis, M. Rahim, T. Rios-Cruz, D. Rodrigues, G. Rozov, D. Sakakushev, B. Sall, I. Sazhin, A. Semião, M. Sharda, T. Shelat, V. Sinibaldi, G. Skicko, D. Skrovina, M. Stamatiou, D. Stella, M. Strzałka, M. Sydorchuk, R

Abstract

Background: Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods: This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results: A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8. Conclusions: The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality. © 2019 The Author(s).

Published
2019

5. 2018 WSES/SIS-E consensus conference: Recommendations for the management of skin and soft-tissue infections

Author

Sartelli, M. Guirao, X. Hardcastle, T.C. Kluger, Y. Boermeester, M.A. Raşa, K. Ansaloni, L. Coccolini, F. Montravers, P. Abu-Zidan, F.M. Bartoletti, M. Bassetti, M. Ben-Ishay, O. Biffl, W.L. Chiara, O. Chiarugi, M. Coimbra, R. De Rosa, F.G. De Simone, B. Di Saverio, S. Giannella, M. Gkiokas, G. Khokha, V. Labricciosa, F.M. Leppäniemi, A. Litvin, A. Moore, E.E. Negoi, I. Pagani, L. Peghin, M. Picetti, E. Pintar, T. Pupelis, G. Rubio-Perez, I. Sakakushev, B. Segovia-Lohse, H. Sganga, G. Shelat, V. Sugrue, M. Tarasconi, A. Tranà, C. Ulrych, J. Viale, P. Catena, F.

Abstract

Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections. SSTIs are a frequent clinical problem in surgical departments. In order to clarify key issues in the management of SSTIs, a task force of experts met in Bertinoro, Italy, on June 28, 2018, for a specialist multidisciplinary consensus conference under the auspices of the World Society of Emergency Surgery (WSES) and the Surgical Infection Society Europe (SIS-E). The multifaceted nature of these infections has led to a collaboration among general and emergency surgeons, intensivists, and infectious disease specialists, who have shared these clinical practice recommendations. © 2018 The Author(s).

Published
2018

6. Prospective Observational Study on acute Appendicitis Worldwide (POSAW)

Author

Sartelli, M. Baiocchi, G.L. Di Saverio, S. Ferrara, F. Labricciosa, F.M. Ansaloni, L. Coccolini, F. Vijayan, D. Abbas, A. Abongwa, H.K. Agboola, J. Ahmed, A. Akhmeteli, L. Akkapulu, N. Akkucuk, S. Altintoprak, F. Andreiev, A.L. Anyfantakis, D. Atanasov, B. Bala, M. Balalis, D. Baraket, O. Bellanova, G. Beltran, M. Melo, R.B. Bini, R. Bouliaris, K. Brunelli, D. Castillo, A. Catani, M. Che Jusoh, A. Chichom-Mefire, A. Cocorullo, G. Coimbra, R. Colak, E. Costa, S. Das, K. Delibegovic, S. Demetrashvili, Z. Di Carlo, I. Kiseleva, N. El Zalabany, T. Faro, M. Ferreira, M. Fraga, G.P. Gachabayov, M. Ghnnam, W.M. Giménez Maurel, T. Gkiokas, G. Gomes, C.A. Griffiths, E. Guner, A. Gupta, S. Hecker, A. Hirano, E.S. Hodonou, A. Hutan, M. Ioannidis, O. Isik, A. Ivakhov, G. Jain, S. Jokubauskas, M. Karamarkovic, A. Kauhanen, S. Kaushik, R. Kavalakat, A. Kenig, J. Khokha, V. Khor, D. Kim, D. Kim, J.I. Kong, V. Lasithiotakis, K. Leão, P. Leon, M. Litvin, A. Lohsiriwat, V. López-Tomassetti Fernandez, E. Lostoridis, E. Maciel, J. Major, P. Dimova, A. Manatakis, D. Marinis, A. Martinez-Perez, A. Marwah, S. McFarlane, M. Mesina, C. Pȩdziwiatr, M. Michalopoulos, N. Misiakos, E. Mohamedahmed, A. Moldovanu, R. Montori, G. Mysore Narayana, R. Negoi, I. Nikolopoulos, I. Novelli, G. Novikovs, V. Olaoye, I. Omari, A. Ordoñez, C.A. Ouadii, M. Ozkan, Z. Pal, A. Palini, G.M. Partecke, L.I. Pata, F. Pȩdziwiatr, M. Pereira Júnior, G.A. Pintar, T. Pisarska, M. Ploneda-Valencia, C.F. Pouggouras, K. Prabhu, V. Ramakrishnapillai, P. Regimbeau, J.-M. Reitz, M. Rios-Cruz, D. Saar, S. Sakakushev, B. Seretis, C. Sazhin, A. Shelat, V. Skrovina, M. Smirnov, D. Spyropoulos, C. Strzałka, M. Talving, P. Teixeira Gonsaga, R.A. Theobald, G. Tomadze, G. Torba, M. Tranà, C. Ulrych, J. Uzunoğlu, M.Y. Vasilescu, A. Occhionorelli, S. Venara, A. Vereczkei, A. Vettoretto, N. Vlad, N. Walȩdziak, M. Yilmaz, T.U. Yuan, K.-C. Yunfeng, C. Zilinskas, J. Grelpois, G. Catena, F. and Sartelli, M. Baiocchi, G.L. Di Saverio, S. Ferrara, F. Labricciosa, F.M. Ansaloni, L. Coccolini, F. Vijayan, D. Abbas, A. Abongwa, H.K. Agboola, J. Ahmed, A. Akhmeteli, L. Akkapulu, N. Akkucuk, S. Altintoprak, F. Andreiev, A.L. Anyfantakis, D. Atanasov, B. Bala, M. Balalis, D. Baraket, O. Bellanova, G. Beltran, M. Melo, R.B. Bini, R. Bouliaris, K. Brunelli, D. Castillo, A. Catani, M. Che Jusoh, A. Chichom-Mefire, A. Cocorullo, G. Coimbra, R. Colak, E. Costa, S. Das, K. Delibegovic, S. Demetrashvili, Z. Di Carlo, I. Kiseleva, N. El Zalabany, T. Faro, M. Ferreira, M. Fraga, G.P. Gachabayov, M. Ghnnam, W.M. Giménez Maurel, T. Gkiokas, G. Gomes, C.A. Griffiths, E. Guner, A. Gupta, S. Hecker, A. Hirano, E.S. Hodonou, A. Hutan, M. Ioannidis, O. Isik, A. Ivakhov, G. Jain, S. Jokubauskas, M. Karamarkovic, A. Kauhanen, S. Kaushik, R. Kavalakat, A. Kenig, J. Khokha, V. Khor, D. Kim, D. Kim, J.I. Kong, V. Lasithiotakis, K. Leão, P. Leon, M. Litvin, A. Lohsiriwat, V. López-Tomassetti Fernandez, E. Lostoridis, E. Maciel, J. Major, P. Dimova, A. Manatakis, D. Marinis, A. Martinez-Perez, A. Marwah, S. McFarlane, M. Mesina, C. Pȩdziwiatr, M. Michalopoulos, N. Misiakos, E. Mohamedahmed, A. Moldovanu, R. Montori, G. Mysore Narayana, R. Negoi, I. Nikolopoulos, I. Novelli, G. Novikovs, V. Olaoye, I. Omari, A. Ordoñez, C.A. Ouadii, M. Ozkan, Z. Pal, A. Palini, G.M. Partecke, L.I. Pata, F. Pȩdziwiatr, M. Pereira Júnior, G.A. Pintar, T. Pisarska, M. Ploneda-Valencia, C.F. Pouggouras, K. Prabhu, V. Ramakrishnapillai, P. Regimbeau, J.-M. Reitz, M. Rios-Cruz, D. Saar, S. Sakakushev, B. Seretis, C. Sazhin, A. Shelat, V. Skrovina, M. Smirnov, D. Spyropoulos, C. Strzałka, M. Talving, P. Teixeira Gonsaga, R.A. Theobald, G. Tomadze, G. Torba, M. Tranà, C. Ulrych, J. Uzunoğlu, M.Y. Vasilescu, A. Occhionorelli, S. Venara, A. Vereczkei, A. Vettoretto, N. Vlad, N. Walȩdziak, M. Yilmaz, T.U. Yuan, K.-C. Yunfeng, C. Zilinskas, J. Grelpois, G. Catena, F.

Abstract

Background: Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments. Methods: This prospective multicenter observational study was performed in 116 worldwide surgical departments from 44 countries over a 6-month period (April 1, 2016-September 30, 2016). All consecutive patients admitted to surgical departments with a clinical diagnosis of AA were included in the study. Results: A total of 4282 patients were enrolled in the POSAW study, 1928 (45%) women and 2354 (55%) men, with a median age of 29 years. Nine hundred and seven (21.2%) patients underwent an abdominal CT scan, 1856 (43.3%) patients an US, and 285 (6.7%) patients both CT scan and US. A total of 4097 (95.7%) patients underwent surgery; 1809 (42.2%) underwent open appendectomy and 2215 (51.7%) had laparoscopic appendectomy. One hundred eighty-five (4.3%) patients were managed conservatively. Major complications occurred in 199 patients (4.6%). The overall mortality rate was 0.28%. Conclusions: The results of the present study confirm the clinical value of imaging techniques and prognostic scores. Appendectomy remains the most effective treatment of acute appendicitis. Mortality rate is low. © 2018 The Author(s).

Published
2018

7. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author

Sartelli, M. Kluger, Y. Ansaloni, L. Carlet, J. Brink, A. Hardcastle, T.C. Khanna, A. Chicom-Mefire, A. Rodríguez-Baño, J. Nathwani, D. Mendelson, M. Watkins, R.R. Pulcini, C. Beović, B. May, A.K. Itani, K.M.F. Mazuski, J.E. Fry, D.E. Coccolini, F. Rasxa, K. Montravers, P. Eckmann, C. Abbo, L.M. Abubakar, S. Abu-Zidan, F.M. Adesunkanmi, A.K. Al-Hasan, M.N. Althani, A.A. Ticas, J.E.A. Ansari, S. Ansumana, R. Da Silva, A.R.A. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bassetti, M. Bellanova, G. Beltran, M.A. Ben-Ishay, O. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Bueno, J. Cainzos, M.A. Cairns, K. Camacho-Ortiz, A. Ceresoli, M. Chandy, S.J. Cherry-Bukowiec, J.R. Cirocchi, R. Colak, E. Corcione, A. Cornely, O.A. Cortese, F. Cui, Y. Curcio, D. Damaskos, D. Dasx, K. Delibegovic, S. Demetrashvili, Z. De Simone, B. De Souza, H.P. De Waele, J. Dhingra, S. Diaz, J.J. Di Carlo, I. Di Marzo, F. Di Saverio, S. Dogjani, A. Dorj, G. Dortet, L. Duane, T.M. Dupont, H. Egiev, V.N. Eid, H.O. Elmangory, M. El-Sayed Marei, H. Enani, M.A. Escandón-Vargas, K. Faro, M.P., Jr. Ferrada, P. Foghetti, D. Foianini, E. Fraga, G.P. Frattima, S. Gandhi, C. Gattuso, G. Giamarellou, E. Ghnnam, W. Gkiokas, G. Girardis, M. Goff, D.A. Gomes, C.A. Gomi, H. Gronerth, R.I.G. Guirao, X. Guzman-Blanco, M. Haque, M. Hecker, A. Hell, M. Herzog, T. Hicks, L. Kafka-Ritsch, R. Kao, L.S. Kanj, S.S. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kashuk, J. Kenig, J. Khamis, F. Khokha, V. Kiguba, R. Kirkpatrick, A.W. Kørner, H. Koike, K. Kok, K.Y.Y. Kon, K. Kong, V. Inaba, K. Ioannidis, O. Isik, A. Iskandar, K. Labbate, M. Labricciosa, F.M. Lagrou, K. Lagunes, L. Latifi, R. Lasithiotakis, K. Laxminarayan, R. Lee, J.G. Leone, M. Leppäniemi, A. Li, Y. Liang, S.Y. Liau, K.-H. Litvin, A. Loho, T. Lowman, W. Machain, G.M. Maier, R.V. Manzano-Nunez, R. Marinis, A. Marmorale, C. Martin-Loeches, I. Marwah, S. Maseda, E. McFarlane, M. De Melo, R.B. Melotti, M.R. Memish, Z. Mertz, D. Mesina, C. Menichetti, F. Mishra, S.K. Montori, G. Moore, E.E. Moore, F.A. Naidoo, N. Napolitano, L. Negoi, I. Nicolau, D.P. Nikolopoulos, I. Nord, C.E. Ofori-Asenso, R. Olaoye, I. Omari, A.H. Ordoñez, C.A. Ouadii, M. Ouedraogo, A.-S. Pagani, L. Paiva, J.A. Parreira, J.G. Pata, F. Pereira, J. Pereira, N.R. Petrosillo, N. Picetti, E. Pintar, T. Ponce-De-Leon, A. Popovski, Z. Poulakou, G. Preller, J. Guerrero, A.P. Pupelis, G. Quiodettis, M. Rawson, T.M. Reichert, M. Reinhart, K. Rems, M. Rello, J. Rizoli, S. Roberts, J. Rubio-Perez, I. Ruppé, E. Sakakushev, B. Sall, I. Kafil, H.S. Sanders, J. Sato, N. Sawyer, R.G. Scalea, T. Scibé, R. Scudeller, L. Lohse, H.S. Sganga, G. Shafiq, N. Shah, J.N. Spigaglia, P. Suroowan, S. Tsioutis, C. Sifri, C.D. Siribumrungwong, B. Sugrue, M. Talving, P. Tan, B.K. Tarasconi, A. Tascini, C. Tilsed, J. Timsit, J.-F. Tumbarello, M. Trung, N.T. Ulrych, J. Uranues, S. Velmahos, G. Vereczkei, A.G. Viale, P. Estape, J.V. Viscoli, C. Wagenlehner, F. Wright, B.J. Xiao, Y. Yuan, K.-C. Zachariah, S.K. Zahar, J.R. Mergulhão, P. Catena, F.

Abstract

This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages. © Copyright 2017, Mary Ann Liebert, Inc.

Published
2017

8. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author

Sartelli, M. Weber, D.G. Ruppé, E. Bassetti, M. Wright, B.J. Ansaloni, L. Catena, F. Coccolini, F. Abu-Zidan, F.M. Coimbra, R. Moore, E.E. Moore, F.A. Maier, R.V. De Waele, J.J. Kirkpatrick, A.W. Griffiths, E.A. Eckmann, C. Brink, A.J. Mazuski, J.E. May, A.K. Sawyer, R.G. Mertz, D. Montravers, P. Kumar, A. Roberts, J.A. Vincent, J.L. Watkins, R.R. Lowman, W. Spellberg, B. Abbott, I.J. Adesunkanmi, A.K. Al-Dahir, S. Al-Hasan, M.N. Agresta, F. Althani, A.A. Ansari, S. Ansumana, R. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bhangu, A. Beltrán, M.A. Bernhard, M. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Cherry-Bukowiec, J.R. Buyne, O.R. Cainzos, M.A. Cairns, K.A. Camacho-Ortiz, A. Chandy, S.J. Che Jusoh, A. Chichom-Mefire, A. Colijn, C. Corcione, F. Cui, Y. Curcio, D. Delibegovic, S. Demetrashvili, Z. De Simone, B. Dhingra, S. Diaz, J.J. Di Carlo, I. Dillip, A. Di Saverio, S. Doyle, M.P. Dorj, G. Dogjani, A. Dupont, H. Eachempati, S.R. Enani, M.A. Egiev, V.N. Elmangory, M.M. Ferrada, P. Fitchett, J.R. Fraga, G.P. Guessennd, N. Giamarellou, H. Ghnnam, W. Gkiokas, G. Goldberg, S.R. Gomes, C.A. Gomi, H. Guzmán-Blanco, M. Haque, M. Hansen, S. Hecker, A. Heizmann, W.R. Herzog, T. Hodonou, A.M. Hong, S.K. Kafka-Ritsch, R. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kees, M.G. Kenig, J. Kiguba, R. Kim, P.K. Kluger, Y. Khokha, V. Koike, K. Kok, K.Y. Kong, V. Knox, M.C. Inaba, K. Isik, A. Iskandar, K. Ivatury, R.R. Labbate, M. Labricciosa, F.M. Laterre, P.F. Latifi, R. Lee, J.G. Lee, Y.R. Leone, M. Leppaniemi, A. Li, Y. Liang, S.Y. Loho, T. Maegele, M. Malama, S. Marei, H.E. Martin-Loeches, I. Marwah, S. Massele, A. McFarlane, M. Melo, R.B. Negoi, I. Nicolau, D.P. Nord, C.E. Ofori-Asenso, R. Omari, A.H. Ordonez, C.A. Ouadii, M. Pereira Júnior, G.A. Piazza, D. Pupelis, G. Rawson, T.M. Rems, M. Rizoli, S. Rocha, C. Sakakushev, B. Sanchez-Garcia, M. Sato, N. Segovia Lohse, H.A. Sganga, G. Siribumrungwong, B. Shelat, V.G. Soreide, K. Soto, R. Talving, P. Tilsed, J.V. Timsit, J.F. Trueba, G. Trung, N.T. Ulrych, J. van Goor, H. Vereczkei, A. Vohra, R.S. Wani, I. Uhl, W. Xiao, Y. Yuan, K.C. Zachariah, S.K. Zahar, J.R. Zakrison, T.L. Corcione, A. Melotti, R.M. Viscoli, C. Viale, P.

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

The original article [1] contains an error whereby a co-author, Boris Sakakushev has their family name spelt incorrectly as 'Sakakhushev'. The authors would therefore like it known that the correct spelling of the family name is 'Sakakushev'. © The Author(s).

Published
2017

9. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author

Sartelli, M. Weber, D.G. Ruppé, E. Bassetti, M. Wright, B.J. Ansaloni, L. Catena, F. Coccolini, F. Abu-Zidan, F.M. Coimbra, R. Moore, E.E. Moore, F.A. Maier, R.V. De Waele, J.J. Kirkpatrick, A.W. Griffiths, E.A. Eckmann, C. Brink, A.J. Mazuski, J.E. May, A.K. Sawyer, R.G. Mertz, D. Montravers, P. Kumar, A. Roberts, J.A. Vincent, J.L. Watkins, R.R. Lowman, W. Spellberg, B. Abbott, I.J. Adesunkanmi, A.K. Al-Dahir, S. Al-Hasan, M.N. Agresta, F. Althani, A.A. Ansari, S. Ansumana, R. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bhangu, A. Beltrán, M.A. Bernhard, M. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Cherry-Bukowiec, J.R. Buyne, O.R. Cainzos, M.A. Cairns, K.A. Camacho-Ortiz, A. Chandy, S.J. Che Jusoh, A. Chichom-Mefire, A. Colijn, C. Corcione, F. Cui, Y. Curcio, D. Delibegovic, S. Demetrashvili, Z. De Simone, B. Dhingra, S. Diaz, J.J. Di Carlo, I. Dillip, A. Di Saverio, S. Doyle, M.P. Dorj, G. Dogjani, A. Dupont, H. Eachempati, S.R. Enani, M.A. Egiev, V.N. Elmangory, M.M. Ferrada, P. Fitchett, J.R. Fraga, G.P. Guessennd, N. Giamarellou, H. Ghnnam, W. Gkiokas, G. Goldberg, S.R. Gomes, C.A. Gomi, H. Guzmán-Blanco, M. Haque, M. Hansen, S. Hecker, A. Heizmann, W.R. Herzog, T. Hodonou, A.M. Hong, S.K. Kafka-Ritsch, R. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kees, M.G. Kenig, J. Kiguba, R. Kim, P.K. Kluger, Y. Khokha, V. Koike, K. Kok, K.Y. Kong, V. Knox, M.C. Inaba, K. Isik, A. Iskandar, K. Ivatury, R.R. Labbate, M. Labricciosa, F.M. Laterre, P.F. Latifi, R. Lee, J.G. Lee, Y.R. Leone, M. Leppaniemi, A. Li, Y. Liang, S.Y. Loho, T. Maegele, M. Malama, S. Marei, H.E. Martin-Loeches, I. Marwah, S. Massele, A. McFarlane, M. Melo, R.B. Negoi, I. Nicolau, D.P. Nord, C.E. Ofori-Asenso, R. Omari, A.H. Ordonez, C.A. Ouadii, M. Pereira Júnior, G.A. Piazza, D. Pupelis, G. Rawson, T.M. Rems, M. Rizoli, S. Rocha, C. Sakakushev, B. Sanchez-Garcia, M. Sato, N. Segovia Lohse, H.A. Sganga, G. Siribumrungwong, B. Shelat, V.G. Soreide, K. Soto, R. Talving, P. Tilsed, J.V. Timsit, J.F. and Sartelli, M. Weber, D.G. Ruppé, E. Bassetti, M. Wright, B.J. Ansaloni, L. Catena, F. Coccolini, F. Abu-Zidan, F.M. Coimbra, R. Moore, E.E. Moore, F.A. Maier, R.V. De Waele, J.J. Kirkpatrick, A.W. Griffiths, E.A. Eckmann, C. Brink, A.J. Mazuski, J.E. May, A.K. Sawyer, R.G. Mertz, D. Montravers, P. Kumar, A. Roberts, J.A. Vincent, J.L. Watkins, R.R. Lowman, W. Spellberg, B. Abbott, I.J. Adesunkanmi, A.K. Al-Dahir, S. Al-Hasan, M.N. Agresta, F. Althani, A.A. Ansari, S. Ansumana, R. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bhangu, A. Beltrán, M.A. Bernhard, M. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Cherry-Bukowiec, J.R. Buyne, O.R. Cainzos, M.A. Cairns, K.A. Camacho-Ortiz, A. Chandy, S.J. Che Jusoh, A. Chichom-Mefire, A. Colijn, C. Corcione, F. Cui, Y. Curcio, D. Delibegovic, S. Demetrashvili, Z. De Simone, B. Dhingra, S. Diaz, J.J. Di Carlo, I. Dillip, A. Di Saverio, S. Doyle, M.P. Dorj, G. Dogjani, A. Dupont, H. Eachempati, S.R. Enani, M.A. Egiev, V.N. Elmangory, M.M. Ferrada, P. Fitchett, J.R. Fraga, G.P. Guessennd, N. Giamarellou, H. Ghnnam, W. Gkiokas, G. Goldberg, S.R. Gomes, C.A. Gomi, H. Guzmán-Blanco, M. Haque, M. Hansen, S. Hecker, A. Heizmann, W.R. Herzog, T. Hodonou, A.M. Hong, S.K. Kafka-Ritsch, R. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kees, M.G. Kenig, J. Kiguba, R. Kim, P.K. Kluger, Y. Khokha, V. Koike, K. Kok, K.Y. Kong, V. Knox, M.C. Inaba, K. Isik, A. Iskandar, K. Ivatury, R.R. Labbate, M. Labricciosa, F.M. Laterre, P.F. Latifi, R. Lee, J.G. Lee, Y.R. Leone, M. Leppaniemi, A. Li, Y. Liang, S.Y. Loho, T. Maegele, M. Malama, S. Marei, H.E. Martin-Loeches, I. Marwah, S. Massele, A. McFarlane, M. Melo, R.B. Negoi, I. Nicolau, D.P. Nord, C.E. Ofori-Asenso, R. Omari, A.H. Ordonez, C.A. Ouadii, M. Pereira Júnior, G.A. Piazza, D. Pupelis, G. Rawson, T.M. Rems, M. Rizoli, S. Rocha, C. Sakakushev, B. Sanchez-Garcia, M. Sato, N. Segovia Lohse, H.A. Sganga, G. Siribumrungwong, B. Shelat, V.G. Soreide, K. Soto, R. Talving, P. Tilsed, J.V. Timsit, J.F.

Abstract

The original article [1] contains an error whereby a co-author, Boris Sakakushev has their family name spelt incorrectly as 'Sakakhushev'. The authors would therefore like it known that the correct spelling of the family name is 'Sakakushev'. © The Author(s).

Published
2017

10. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author

Sartelli, M. Kluger, Y. Ansaloni, L. Carlet, J. Brink, A. Hardcastle, T.C. Khanna, A. Chicom-Mefire, A. Rodríguez-Baño, J. Nathwani, D. Mendelson, M. Watkins, R.R. Pulcini, C. Beović, B. May, A.K. Itani, K.M.F. Mazuski, J.E. Fry, D.E. Coccolini, F. Rasxa, K. Montravers, P. Eckmann, C. Abbo, L.M. Abubakar, S. Abu-Zidan, F.M. Adesunkanmi, A.K. Al-Hasan, M.N. Althani, A.A. Ticas, J.E.A. Ansari, S. Ansumana, R. Da Silva, A.R.A. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bassetti, M. Bellanova, G. Beltran, M.A. Ben-Ishay, O. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Bueno, J. Cainzos, M.A. Cairns, K. Camacho-Ortiz, A. Ceresoli, M. Chandy, S.J. Cherry-Bukowiec, J.R. Cirocchi, R. Colak, E. Corcione, A. Cornely, O.A. Cortese, F. Cui, Y. Curcio, D. Damaskos, D. Dasx, K. Delibegovic, S. Demetrashvili, Z. De Simone, B. De Souza, H.P. De Waele, J. Dhingra, S. Diaz, J.J. Di Carlo, I. Di Marzo, F. Di Saverio, S. Dogjani, A. Dorj, G. Dortet, L. Duane, T.M. Dupont, H. Egiev, V.N. Eid, H.O. Elmangory, M. El-Sayed Marei, H. Enani, M.A. Escandón-Vargas, K. Faro, M.P., Jr. Ferrada, P. Foghetti, D. Foianini, E. Fraga, G.P. Frattima, S. Gandhi, C. Gattuso, G. Giamarellou, E. Ghnnam, W. Gkiokas, G. Girardis, M. Goff, D.A. Gomes, C.A. Gomi, H. Gronerth, R.I.G. Guirao, X. Guzman-Blanco, M. Haque, M. Hecker, A. Hell, M. Herzog, T. Hicks, L. Kafka-Ritsch, R. Kao, L.S. Kanj, S.S. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kashuk, J. Kenig, J. Khamis, F. Khokha, V. Kiguba, R. Kirkpatrick, A.W. Kørner, H. Koike, K. Kok, K.Y.Y. Kon, K. Kong, V. Inaba, K. Ioannidis, O. Isik, A. Iskandar, K. Labbate, M. Labricciosa, F.M. Lagrou, K. Lagunes, L. Latifi, R. Lasithiotakis, K. Laxminarayan, R. Lee, J.G. Leone, M. Leppäniemi, A. Li, Y. Liang, S.Y. Liau, K.-H. Litvin, A. Loho, T. Lowman, W. Machain, G.M. Maier, R.V. Manzano-Nunez, R. Marinis, A. Marmorale, C. Martin-Loeches, I. Marwah, S. Maseda, E. McFarlane, M. De Melo, R.B. Melotti, M.R. Memish, Z. Mertz, D. Mesina, C. Menichetti, F. Mishra, S.K. M and Sartelli, M. Kluger, Y. Ansaloni, L. Carlet, J. Brink, A. Hardcastle, T.C. Khanna, A. Chicom-Mefire, A. Rodríguez-Baño, J. Nathwani, D. Mendelson, M. Watkins, R.R. Pulcini, C. Beović, B. May, A.K. Itani, K.M.F. Mazuski, J.E. Fry, D.E. Coccolini, F. Rasxa, K. Montravers, P. Eckmann, C. Abbo, L.M. Abubakar, S. Abu-Zidan, F.M. Adesunkanmi, A.K. Al-Hasan, M.N. Althani, A.A. Ticas, J.E.A. Ansari, S. Ansumana, R. Da Silva, A.R.A. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bassetti, M. Bellanova, G. Beltran, M.A. Ben-Ishay, O. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Bueno, J. Cainzos, M.A. Cairns, K. Camacho-Ortiz, A. Ceresoli, M. Chandy, S.J. Cherry-Bukowiec, J.R. Cirocchi, R. Colak, E. Corcione, A. Cornely, O.A. Cortese, F. Cui, Y. Curcio, D. Damaskos, D. Dasx, K. Delibegovic, S. Demetrashvili, Z. De Simone, B. De Souza, H.P. De Waele, J. Dhingra, S. Diaz, J.J. Di Carlo, I. Di Marzo, F. Di Saverio, S. Dogjani, A. Dorj, G. Dortet, L. Duane, T.M. Dupont, H. Egiev, V.N. Eid, H.O. Elmangory, M. El-Sayed Marei, H. Enani, M.A. Escandón-Vargas, K. Faro, M.P., Jr. Ferrada, P. Foghetti, D. Foianini, E. Fraga, G.P. Frattima, S. Gandhi, C. Gattuso, G. Giamarellou, E. Ghnnam, W. Gkiokas, G. Girardis, M. Goff, D.A. Gomes, C.A. Gomi, H. Gronerth, R.I.G. Guirao, X. Guzman-Blanco, M. Haque, M. Hecker, A. Hell, M. Herzog, T. Hicks, L. Kafka-Ritsch, R. Kao, L.S. Kanj, S.S. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kashuk, J. Kenig, J. Khamis, F. Khokha, V. Kiguba, R. Kirkpatrick, A.W. Kørner, H. Koike, K. Kok, K.Y.Y. Kon, K. Kong, V. Inaba, K. Ioannidis, O. Isik, A. Iskandar, K. Labbate, M. Labricciosa, F.M. Lagrou, K. Lagunes, L. Latifi, R. Lasithiotakis, K. Laxminarayan, R. Lee, J.G. Leone, M. Leppäniemi, A. Li, Y. Liang, S.Y. Liau, K.-H. Litvin, A. Loho, T. Lowman, W. Machain, G.M. Maier, R.V. Manzano-Nunez, R. Marinis, A. Marmorale, C. Martin-Loeches, I. Marwah, S. Maseda, E. McFarlane, M. De Melo, R.B. Melotti, M.R. Memish, Z. Mertz, D. Mesina, C. Menichetti, F. Mishra, S.K. M

Abstract

This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages. © Copyright 2017, Mary Ann Liebert, Inc.

Published
2017

11. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections

Author

Sartelli, M., Chichom-Mefire, A., Labricciosa, F.M., Hardcastle, T., Abu-Zidan, F.M., Adesunkanmi, A.K., Ansaloni, L., Bala, M., Balogh, Z.J., Beltran, M.A., Ben-Ishay, O., Biffl, W.L., Birindelli, A., Cainzos, M.A., Catalini, G., Ceresoli, M., Che Jusoh, A., Chiara, O., Coccolini, F., Coimbra, R., Cortese, F., Demetrashvili, Z., Saverio, S. Di, Diaz, J.J., Egiev, V.N., Ferrada, P., Fraga, G.P., Ghnnam, W.M., Lee, J.G., Gomes, C.A., Hecker, A., Herzog, T., Kim, J.I., Inaba, K., Isik, A., Karamarkovic, A., Kashuk, J., Khokha, V., Kirkpatrick, A.W., Kluger, Y., Koike, K., Kong, V.Y., Leppaniemi, A., Machain, G.M., Maier, R.V., Marwah, S., McFarlane, M.E., Montori, G., Moore, E.E., Negoi, I., Olaoye, I., Omari, A.H., Ordonez, C.A., Pereira, B.M., Junior, G.A., Pupelis, G., Reis, T., Sakakhushev, B., Sato, N., Segovia Lohse, H.A., Shelat, V.G., Soreide, K., Uhl, W., Ulrych, J., Goor, H. van, Velmahos, G.C., Yuan, K.C., Wani, I., Weber, D.G., Zachariah, S.K., Catena, F., Sartelli, M., Chichom-Mefire, A., Labricciosa, F.M., Hardcastle, T., Abu-Zidan, F.M., Adesunkanmi, A.K., Ansaloni, L., Bala, M., Balogh, Z.J., Beltran, M.A., Ben-Ishay, O., Biffl, W.L., Birindelli, A., Cainzos, M.A., Catalini, G., Ceresoli, M., Che Jusoh, A., Chiara, O., Coccolini, F., Coimbra, R., Cortese, F., Demetrashvili, Z., Saverio, S. Di, Diaz, J.J., Egiev, V.N., Ferrada, P., Fraga, G.P., Ghnnam, W.M., Lee, J.G., Gomes, C.A., Hecker, A., Herzog, T., Kim, J.I., Inaba, K., Isik, A., Karamarkovic, A., Kashuk, J., Khokha, V., Kirkpatrick, A.W., Kluger, Y., Koike, K., Kong, V.Y., Leppaniemi, A., Machain, G.M., Maier, R.V., Marwah, S., McFarlane, M.E., Montori, G., Moore, E.E., Negoi, I., Olaoye, I., Omari, A.H., Ordonez, C.A., Pereira, B.M., Junior, G.A., Pupelis, G., Reis, T., Sakakhushev, B., Sato, N., Segovia Lohse, H.A., Shelat, V.G., Soreide, K., Uhl, W., Ulrych, J., Goor, H. van, Velmahos, G.C., Yuan, K.C., Wani, I., Weber, D.G., Zachariah, S.K., and Catena, F.

Abstract

Contains fulltext : 175669.pdf (publisher's version ) (Open Access), Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in the emergency departments worldwide. The cornerstones of effective treatment of IAIs are early recognition, adequate source control, and appropriate antimicrobial therapy. Prompt resuscitation of patients with ongoing sepsis is of utmost important. In hospitals worldwide, non-acceptance of, or lack of access to, accessible evidence-based practices and guidelines result in overall poorer outcome of patients suffering IAIs. The aim of this paper is to promote global standards of care in IAIs and update the 2013 WSES guidelines for management of intra-abdominal infections.

Published
2017

12. The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey

Author

Sartelli, M., Labricciosa, F.M., Barbadoro, P., Pagani, L., Ansaloni, L., Brink, A.J., Carlet, J., Khanna, A., Chichom-Mefire, A., Coccolini, F., Saverio, S. Di, May, A.K., Viale, P., Watkins, R.R., Scudeller, L., Abbo, L.M., Abu-Zidan, F.M., Adesunkanmi, A.K., Al-Dahir, S., Al-Hasan, M.N., Alis, H., Alves, C., Araujo da Silva, A.R., Augustin, G., Bala, M., Barie, P.S., Beltran, M.A., Bhangu, A., Bouchra, B., Brecher, S.M., Cainzos, M.A., Camacho-Ortiz, A., Catani, M., Chandy, S.J., Jusoh, A.C., Cherry-Bukowiec, J.R., Chiara, O., Colak, E., Cornely, O.A., Cui, Y., Demetrashvili, Z., Simone, B. De, Waele, J.J. De, Dhingra, S., Marzo, F. Di, Dogjani, A., Dorj, G., Dortet, L., Duane, T.M., Elmangory, M.M., Enani, M.A., Ferrada, P., Esteban Foianini, J., Gachabayov, M., Gandhi, C., Ghnnam, W.M., Giamarellou, H., Gkiokas, G., Gomi, H., Goranovic, T., Griffiths, E.A., Guerra Gronerth, R.I., Haidamus Monteiro, J.C., Hardcastle, T.C., Hecker, A., Hodonou, A.M., Ioannidis, O., Isik, A., Iskandar, K.A., Kafil, H.S., Kanj, S.S., Kaplan, L.J., Kapoor, G., Karamarkovic, A.R., Kenig, J., Kerschaever, I., Khamis, F., Khokha, V., Kiguba, R., Kim, H.B., Ko, W.C., Koike, K., Kozlovska, I., Kumar, A., Lagunes, L., Latifi, R., Lee, J.G., Lee, Y.R., Leppaniemi, A., Li, Y., Liang, S.Y., Lowman, W., Machain, G.M., Maegele, M., Major, P., Malama, S., Manzano-Nunez, R., Marinis, A., Casas, I., Goor, H. van, Zuidema, W.P., Catena, F., Sartelli, M., Labricciosa, F.M., Barbadoro, P., Pagani, L., Ansaloni, L., Brink, A.J., Carlet, J., Khanna, A., Chichom-Mefire, A., Coccolini, F., Saverio, S. Di, May, A.K., Viale, P., Watkins, R.R., Scudeller, L., Abbo, L.M., Abu-Zidan, F.M., Adesunkanmi, A.K., Al-Dahir, S., Al-Hasan, M.N., Alis, H., Alves, C., Araujo da Silva, A.R., Augustin, G., Bala, M., Barie, P.S., Beltran, M.A., Bhangu, A., Bouchra, B., Brecher, S.M., Cainzos, M.A., Camacho-Ortiz, A., Catani, M., Chandy, S.J., Jusoh, A.C., Cherry-Bukowiec, J.R., Chiara, O., Colak, E., Cornely, O.A., Cui, Y., Demetrashvili, Z., Simone, B. De, Waele, J.J. De, Dhingra, S., Marzo, F. Di, Dogjani, A., Dorj, G., Dortet, L., Duane, T.M., Elmangory, M.M., Enani, M.A., Ferrada, P., Esteban Foianini, J., Gachabayov, M., Gandhi, C., Ghnnam, W.M., Giamarellou, H., Gkiokas, G., Gomi, H., Goranovic, T., Griffiths, E.A., Guerra Gronerth, R.I., Haidamus Monteiro, J.C., Hardcastle, T.C., Hecker, A., Hodonou, A.M., Ioannidis, O., Isik, A., Iskandar, K.A., Kafil, H.S., Kanj, S.S., Kaplan, L.J., Kapoor, G., Karamarkovic, A.R., Kenig, J., Kerschaever, I., Khamis, F., Khokha, V., Kiguba, R., Kim, H.B., Ko, W.C., Koike, K., Kozlovska, I., Kumar, A., Lagunes, L., Latifi, R., Lee, J.G., Lee, Y.R., Leppaniemi, A., Li, Y., Liang, S.Y., Lowman, W., Machain, G.M., Maegele, M., Major, P., Malama, S., Manzano-Nunez, R., Marinis, A., Casas, I., Goor, H. van, Zuidema, W.P., and Catena, F.

Abstract

Contains fulltext : 177987.pdf (publisher's version ) (Open Access), BACKGROUND: Antimicrobial Stewardship Programs (ASPs) have been promoted to optimize antimicrobial usage and patient outcomes, and to reduce the emergence of antimicrobial-resistant organisms. However, the best strategies for an ASP are not definitively established and are likely to vary based on local culture, policy, and routine clinical practice, and probably limited resources in middle-income countries. The aim of this study is to evaluate structures and resources of antimicrobial stewardship teams (ASTs) in surgical departments from different regions of the world. METHODS: A cross-sectional web-based survey was conducted in 2016 on 173 physicians who participated in the AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections) project and on 658 international experts in the fields of ASPs, infection control, and infections in surgery. RESULTS: The response rate was 19.4%. One hundred fifty-six (98.7%) participants stated their hospital had a multidisciplinary AST. The median number of physicians working inside the team was five [interquartile range 4-6]. An infectious disease specialist, a microbiologist and an infection control specialist were, respectively, present in 80.1, 76.3, and 67.9% of the ASTs. A surgeon was a component in 59.0% of cases and was significantly more likely to be present in university hospitals (89.5%, p < 0.05) compared to community teaching (83.3%) and community hospitals (66.7%). Protocols for pre-operative prophylaxis and for antimicrobial treatment of surgical infections were respectively implemented in 96.2 and 82.3% of the hospitals. The majority of the surgical departments implemented both persuasive and restrictive interventions (72.8%). The most common types of interventions in surgical departments were dissemination of educational materials (62.5%), expert approval (61.0%), audit and feedback (55.1%), educational outreach (53.7%), and compulsory order forms (51.5%). CONCLUSION: T

Published
2017

13. It is time to define an organizational model for the prevention and management of infections along the surgical pathway : a worldwide cross-sectional survey

Author

Massimo Sartelli, Francesco M. Labricciosa, Federico Coccolini, Raul Coimbra, Fikri M. Abu-Zidan, Luca Ansaloni, Majdi N. Al-Hasan, Shamshul Ansari, Philip S. Barie, Miguel Angel Caínzos, Marco Ceresoli, Massimo Chiarugi, Jeffrey A. Claridge, Enrico Cicuttin, Evan Patchen Dellinger, Donald E. Fry, Xavier Guirao, Timothy Craig Hardcastle, Andreas Hecker, Ari K. Leppäniemi, Andrey Litvin, Sanjay Marwah, Emilio Maseda, John E. Mazuski, Ziad Ahmed Memish, Andrew W. Kirkpatrick, Leonardo Pagani, Mauro Podda, Huseyin Kemal Rasa, Boris E. Sakakushev, Robert G. Sawyer, Fabio Tumietto, Yonghong Xiao, Wedad Faraj Aboubreeg, Harissou Adamou, Lali Akhmeteli, Emrah Akin, Maria Grazia Alberio, Felipe Alconchel, Ibrahim Amadou Magagi, Ana Belén Araúz, Giulio Argenio, Boyko C. Atanasov, Semra Demirli Atici, Selmy Sabry Awad, Efstratia Baili, Lovenish Bains, Miklosh Bala, Oussama Baraket, Suman Baral, Vladislav A. Belskii, Moussa Benboubker, Offir Ben-Ishay, Pierpaolo Bordoni, Abdalia Boumédiène, Giuseppe Brisinda, Laura Cavazzuti, Sujith J. Chandy, Maria Michela Chiarello, Nicola Cillara, Guglielmo Clarizia, Maria-Elena Cocuz, Iuliu Gabriel Cocuz, Luigi Conti, Raffaella Coppola, Yunfeng Cui, Jacek Czepiel, Fabrizio D’Acapito, Dimitrios Damaskos, Koray Das, Belinda De Simone, Samir Delibegovic, Zaza Demetrashvili, Dzemail S. Detanac, Sameer Dhingra, Stefano Di Bella, Evgeni N. Dimitrov, Agron Dogjani, Mario D’Oria, Irina Magdalena Dumitru, Mutasim M. Elmangory, Octavian Enciu, Massimo Fantoni, Daniela Filipescu, Francesco Fleres, Domitilla Foghetti, Pietro Fransvea, Mahir Gachabayov, Rita Galeiras, Gianni Gattuso, Wagih M. Ghannam, Valeria Ghisetti, Giorgio Giraudo, Kebebe Bekele Gonfa, Emre Gonullu, Yousif Tag Elsir Y. Hamad, Matthias Hecker, Arda Isik, Nizar Ismail, Azzain Ismail, Sumita Agarwal Jain, Souha S. Kanj, Garima Kapoor, Ilias Karaiskos, Alfie J. Kavalakat, Jakub Kenig, Faryal Khamis, Vladimir Khokha, Ronald Kiguba, Jae Il Kim, Yoshiro Kobe, Kenneth Yuh Yen Kok, Bojan M. Kovacevic, Igor Andreevich Kryvoruchko, Akira Kuriyama, Aitor Landaluce-Olavarria, Konstantinos Lasithiotakis, Varut Lohsiriwat, Eftychios Lostoridis, Davide Luppi, Gustavo Miguel Machain Vega, Marc Maegele, Athanasios Marinis, Gennaro Martines, Aleix Martínez-Pérez, Damien Massalou, Cristian Mesina, Gökhan Metan, María Guadalupe Miranda-Novales, Shyam Kumar Mishra, Mohaned Ibrahim Hussein Mohamed, Ali Yasen Y. Mohamedahmed, Ismael Mora-Guzmán, Francesk Mulita, Ana-Maria Musina, Pradeep H. Navsaria, Ionut Negoi, Gabriela Elisa Nita, Donal B. O’Connor, Carlos Alberto Ordoñez, Desiré Pantalone, Arpád Panyko, Aristeidis Papadopoulos, Nikolaos Pararas, Francesco Pata, Tapan Patel, Gianluca Pellino, Teresa Perra, Gennaro Perrone, Antonio Pesce, Tadeja Pintar, Georgi Ivanov Popivanov, Alberto Porcu, Martha Alexa Quiodettis, Razrim Rahim, Ashrarur Rahman Mitul, Martin Reichert, Miran Rems, Glendee Yolande Reynolds Campbell, Nuno Rocha-Pereira, Gabriel Rodrigues, Gustavo Eduardo Roncancio Villamil, Stefano Rossi, Ibrahima Sall, Hossein Samadi Kafil, Diego Sasia, Jeremiah Seni, Charalampos Seretis, Mario Serradilla-Martín, Vishal G. Shelat, Boonying Siribumrungwong, Mihail Slavchev, Leonardo Solaini, Boun Kim Tan, Antonio Tarasconi, Dario Tartaglia, Elena Adelina Toma, Gia Tomadze, Adriana Toro, Marcos Roberto Tovani-Palone, Harry van Goor, Alin Vasilescu, Andras Vereczkei, Massimiliano Veroux, Sergio Alberto Weckmann, Lukas Werner Widmer, AliIbrahim Yahya, Sanoop K. Zachariah, Andee Dzulkarnaen Zakaria, Nadezhda Zubareva, Wietse P. Zuidema, Isidoro Di Carlo, Francesco Cortese, Gian Luca Baiocchi, Ronald V. Maier, Fausto Catena, Surgery, Other Research, AMS - Musculoskeletal Health, APH - Quality of Care, HUS Abdominal Center, II kirurgian klinikka, Sartelli M., Labricciosa F.M., Coccolini F., Coimbra R., Abu-Zidan F.M., Ansaloni L., Al-Hasan M.N., Ansari S., Barie P.S., Cainzos M.A., Ceresoli M., Chiarugi M., Claridge J.A., Cicuttin E., Dellinger E.P., Fry D.E., Guirao X., Hardcastle T.C., Hecker A., Leppaniemi A.K., Litvin A., Marwah S., Maseda E., Mazuski J.E., Memish Z.A., Kirkpatrick A.W., Pagani L., Podda M., Rasa H.K., Sakakushev B.E., Sawyer R.G., Tumietto F., Xiao Y., Aboubreeg W.F., Adamou H., Akhmeteli L., Akin E., Alberio M.G., Alconchel F., Magagi I.A., Arauz A.B., Argenio G., Atanasov B.C., Atici S.D., Awad S.S., Baili E., Bains L., Bala M., Baraket O., Baral S., Belskii V.A., Benboubker M., Ben-Ishay O., Bordoni P., Boumediene A., Brisinda G., Cavazzuti L., Chandy S.J., Chiarello M.M., Cillara N., Clarizia G., Cocuz M.-E., Cocuz I.G., Conti L., Coppola R., Cui Y., Czepiel J., D'Acapito F., Damaskos D., Das K., De Simone B., Delibegovic S., Demetrashvili Z., Detanac D.S., Dhingra S., Di Bella S., Dimitrov E.N., Dogjani A., D'Oria M., Dumitru I.M., Elmangory M.M., Enciu O., Fantoni M., Filipescu D., Fleres F., Foghetti D., Fransvea P., Gachabayov M., Galeiras R., Gattuso G., Ghannam W.M., Ghisetti V., Giraudo G., Gonfa K.B., Gonullu E., Hamad Y.T.E.Y., Hecker M., Isik A., Ismail N., Ismail A., Jain S.A., Kanj S.S., Kapoor G., Karaiskos I., Kavalakat A.J., Kenig J., Khamis F., Khokha V., Kiguba R., Kim J.I., Kobe Y., Kok K.Y.Y., Kovacevic B.M., Kryvoruchko I.A., Kuriyama A., Landaluce-Olavarria A., Lasithiotakis K., Lohsiriwat V., Lostoridis E., Luppi D., Vega G.M.M., Maegele M., Marinis A., Martines G., Martinez-Perez A., Massalou D., Mesina C., Metan G., Miranda-Novales M.G., Mishra S.K., Mohamed M.I.H., Mohamedahmed A.Y.Y., Mora-Guzman I., Mulita F., Musina A.-M., Navsaria P.H., Negoi I., Nita G.E., O'Connor D.B., Ordonez C.A., Pantalone D., Panyko A., Papadopoulos A., Pararas N., Pata F., Patel T., Pellino G., Perra T., Perrone G., Pesce A., Pintar T., Popivanov G.I., Porcu A., Quiodettis M.A., Rahim R., Mitul A.R., Reichert M., Rems M., Campbell G.Y.R., Rocha-Pereira N., Rodrigues G., Villamil G.E.R., Rossi S., Sall I., Kafil H.S., Sasia D., Seni J., Seretis C., Serradilla-Martin M., Shelat V.G., Siribumrungwong B., Slavchev M., Solaini L., Tan B.K., Tarasconi A., Tartaglia D., Toma E.A., Tomadze G., Toro A., Tovani-Palone M.R., van Goor H., Vasilescu A., Vereczkei A., Veroux M., Weckmann S.A., Widmer L.W., Yahya A.I., Zachariah S.K., Zakaria A.D., Zubareva N., Zuidema W.P., Di Carlo I., Cortese F., Baiocchi G.L., Maier R.V., Catena F., Sartelli, M, Labricciosa, F, Coccolini, F, Coimbra, R, Abu-Zidan, F, Ansaloni, L, Al-Hasan, M, Ansari, S, Barie, P, Cainzos, M, Ceresoli, M, Chiarugi, M, Claridge, J, Cicuttin, E, Dellinger, E, Fry, D, Guirao, X, Hardcastle, T, Hecker, A, Leppaniemi, A, Litvin, A, Marwah, S, Maseda, E, Mazuski, J, Memish, Z, Kirkpatrick, A, Pagani, L, Podda, M, Rasa, H, Sakakushev, B, Sawyer, R, Tumietto, F, Xiao, Y, Aboubreeg, W, Adamou, H, Akhmeteli, L, Akin, E, Alberio, M, Alconchel, F, Magagi, I, Arauz, A, Argenio, G, Atanasov, B, Atici, S, Awad, S, Baili, E, Bains, L, Bala, M, Baraket, O, Baral, S, Belskii, V, Benboubker, M, Ben-Ishay, O, Bordoni, P, Boumediene, A, Brisinda, G, Cavazzuti, L, Chandy, S, Chiarello, M, Cillara, N, Clarizia, G, Cocuz, M, Cocuz, I, Conti, L, Coppola, R, Cui, Y, Czepiel, J, D'Acapito, F, Damaskos, D, Das, K, De Simone, B, Delibegovic, S, Demetrashvili, Z, Detanac, D, Dhingra, S, Di Bella, S, Dimitrov, E, Dogjani, A, D'Oria, M, Dumitru, I, Elmangory, M, Enciu, O, Fantoni, M, Filipescu, D, Fleres, F, Foghetti, D, Fransvea, P, Gachabayov, M, Galeiras, R, Gattuso, G, Ghannam, W, Ghisetti, V, Giraudo, G, Gonfa, K, Gonullu, E, Hamad, Y, Hecker, M, Isik, A, Ismail, N, Ismail, A, Jain, S, Kanj, S, Kapoor, G, Karaiskos, I, Kavalakat, A, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kim, J, Kobe, Y, Kok, K, Kovacevic, B, Kryvoruchko, I, Kuriyama, A, Landaluce-Olavarria, A, Lasithiotakis, K, Lohsiriwat, V, Lostoridis, E, Luppi, D, Vega, G, Maegele, M, Marinis, A, Martines, G, Martinez-Perez, A, Massalou, D, Mesina, C, Metan, G, Miranda-Novales, M, Mishra, S, Mohamed, M, Mohamedahmed, A, Mora-Guzman, I, Mulita, F, Musina, A, Navsaria, P, Negoi, I, Nita, G, O'Connor, D, Ordonez, C, Pantalone, D, Panyko, A, Papadopoulos, A, Pararas, N, Pata, F, Patel, T, Pellino, G, Perra, T, Perrone, G, Pesce, A, Pintar, T, Popivanov, G, Porcu, A, Quiodettis, M, Rahim, R, Mitul, A, Reichert, M, Rems, M, Campbell, G, Rocha-Pereira, N, Rodrigues, G, Villamil, G, Rossi, S, Sall, I, Kafil, H, Sasia, D, Seni, J, Seretis, C, Serradilla-Martin, M, Shelat, V, Siribumrungwong, B, Slavchev, M, Solaini, L, Tan, B, Tarasconi, A, Tartaglia, D, Toma, E, Tomadze, G, Toro, A, Tovani-Palone, M, van Goor, H, Vasilescu, A, Vereczkei, A, Veroux, M, Weckmann, S, Widmer, L, Yahya, A, Zachariah, S, Zakaria, A, Zubareva, N, Zuidema, W, Di Carlo, I, Cortese, F, Baiocchi, G, Maier, R, Catena, F, Sartelli, Massimo, Labricciosa, Francesco M, Coccolini, Federico, Coimbra, Raul, Abu-Zidan, Fikri M, Ansaloni, Luca, Al-Hasan, Majdi N, Ansari, Shamshul, Barie, Philip S, Caínzos, Miguel Angel, Ceresoli, Marco, Chiarugi, Massimo, Claridge, Jeffrey A, Cicuttin, Enrico, Dellinger, Evan Patchen, Fry, Donald E, Guirao, Xavier, Hardcastle, Timothy Craig, Hecker, Andrea, Leppäniemi, Ari K, Litvin, Andrey, Marwah, Sanjay, Maseda, Emilio, Mazuski, John E, Memish, Ziad Ahmed, Kirkpatrick, Andrew W, Pagani, Leonardo, Podda, Mauro, Rasa, Huseyin Kemal, Sakakushev, Boris E, Sawyer, Robert G, Tumietto, Fabio, Xiao, Yonghong, Aboubreeg, Wedad Faraj, Adamou, Harissou, Akhmeteli, Lali, Akin, Emrah, Alberio, Maria Grazia, Alconchel, Felipe, Magagi, Ibrahim Amadou, Araúz, Ana Belén, Argenio, Giulio, Atanasov, Boyko C, Atici, Semra Demirli, Awad, Selmy Sabry, Baili, Efstratia, Bains, Lovenish, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Belskii, Vladislav A, Benboubker, Moussa, Ben-Ishay, Offir, Bordoni, Pierpaolo, Boumédiène, Abdalia, Brisinda, Giuseppe, Cavazzuti, Laura, Chandy, Sujith J, Chiarello, Maria Michela, Cillara, Nicola, Clarizia, Guglielmo, Cocuz, Maria-Elena, Cocuz, Iuliu Gabriel, Conti, Luigi, Coppola, Raffaella, Cui, Yunfeng, Czepiel, Jacek, D'Acapito, Fabrizio, Damaskos, Dimitrio, Das, Koray, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Detanac, Dzemail S, Dhingra, Sameer, Di Bella, Stefano, Dimitrov, Evgeni N, Dogjani, Agron, D'Oria, Mario, Dumitru, Irina Magdalena, Elmangory, Mutasim M, Enciu, Octavian, Fantoni, Massimo, Filipescu, Daniela, Fleres, Francesco, Foghetti, Domitilla, Fransvea, Pietro, Gachabayov, Mahir, Galeiras, Rita, Gattuso, Gianni, Ghannam, Wagih M, Ghisetti, Valeria, Giraudo, Giorgio, Gonfa, Kebebe Bekele, Gonullu, Emre, Hamad, Yousif Tag Elsir Y, Hecker, Matthia, Isik, Arda, Ismail, Nizar, Ismail, Azzain, Jain, Sumita Agarwal, Kanj, Souha S, Kapoor, Garima, Karaiskos, Ilia, Kavalakat, Alfie J, Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Jae Il, Kobe, Yoshiro, Kok, Kenneth Yuh Yen, Kovacevic, Bojan M, Kryvoruchko, Igor Andreevich, Kuriyama, Akira, Landaluce-Olavarria, Aitor, Lasithiotakis, Konstantino, Lohsiriwat, Varut, Lostoridis, Eftychio, Luppi, Davide, Vega, Gustavo Miguel Machain, Maegele, Marc, Marinis, Athanasio, Martines, Gennaro, Martínez-Pérez, Aleix, Massalou, Damien, Mesina, Cristian, Metan, Gökhan, Miranda-Novales, María Guadalupe, Mishra, Shyam Kumar, Mohamed, Mohaned Ibrahim Hussein, Mohamedahmed, Ali Yasen Y, Mora-Guzmán, Ismael, Mulita, Francesk, Musina, Ana-Maria, Navsaria, Pradeep H, Negoi, Ionut, Nita, Gabriela Elisa, O'Connor, Donal B, Ordoñez, Carlos Alberto, Pantalone, Desiré, Panyko, Arpád, Papadopoulos, Aristeidi, Pararas, Nikolao, Pata, Francesco, Patel, Tapan, Pellino, Gianluca, Perra, Teresa, Perrone, Gennaro, Pesce, Antonio, Pintar, Tadeja, Popivanov, Georgi Ivanov, Porcu, Alberto, Quiodettis, Martha Alexa, Rahim, Razrim, Mitul, Ashrarur Rahman, Reichert, Martin, Rems, Miran, Campbell, Glendee Yolande Reynold, Rocha-Pereira, Nuno, Rodrigues, Gabriel, Villamil, Gustavo Eduardo Roncancio, Rossi, Stefano, Sall, Ibrahima, Kafil, Hossein Samadi, Sasia, Diego, Seni, Jeremiah, Seretis, Charalampo, Serradilla-Martín, Mario, Shelat, Vishal G, Siribumrungwong, Boonying, Slavchev, Mihail, Solaini, Leonardo, Tan, Boun Kim, Tarasconi, Antonio, Tartaglia, Dario, Toma, Elena Adelina, Tomadze, Gia, Toro, Adriana, Tovani-Palone, Marcos Roberto, van Goor, Harry, Vasilescu, Alin, Vereczkei, Andra, Veroux, Massimiliano, Weckmann, Sergio Alberto, Widmer, Lukas Werner, Yahya, Aliibrahim, Zachariah, Sanoop K, Zakaria, Andee Dzulkarnaen, Zubareva, Nadezhda, Zuidema, Wietse P, Di Carlo, Isidoro, Cortese, Francesco, Baiocchi, Gian Luca, Maier, Ronald V, Catena, Fausto, Department of Medicine, and Faculty of Health Sciences

Subjects
Anti-Infective Agent, Infection prevention and control, Antibiotic resistance, Settore MED/18 - CHIRURGIA GENERALE, 610 Medicine & health, Antimicrobial stewardship, Cross-sectional survey, Antimicrobial stewardship, Antibiotic prescribing, Antibiotic resistance, Infection prevention and control, Organizational, Antibiotic prescribing, Cross-sectional survey, Anti-Infective Agents, Models, Anti-Bacterial Agent, Humans, Pandemics, Cross-Sectional Studie, ANTIMICROBIAL RESISTANCE, Pandemic, COVID-19, 3126 Surgery, anesthesiology, intensive care, radiology, Anti-Bacterial Agents, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Cross-Sectional Studies, Models, Organizational, HEALTH-CARE, Emergency Medicine, Surgery, Human
Abstract

Background The objectives of the study were to investigate the organizational characteristics of acute care facilities worldwide in preventing and managing infections in surgery; assess participants’ perception regarding infection prevention and control (IPC) measures, antibiotic prescribing practices, and source control; describe awareness about the global burden of antimicrobial resistance (AMR) and IPC measures; and determine the role of the Coronavirus Disease 2019 pandemic on said awareness. Methods A cross-sectional web-based survey was conducted contacting 1432 health care workers (HCWs) belonging to a mailing list provided by the Global Alliance for Infections in Surgery. The self-administered questionnaire was developed by a multidisciplinary team. The survey was open from May 22, 2021, and June 22, 2021. Three reminders were sent, after 7, 14, and 21 days. Results Three hundred four respondents from 72 countries returned a questionnaire, with an overall response rate of 21.2%. Respectively, 90.4% and 68.8% of participants stated their hospital had a multidisciplinary IPC team or a multidisciplinary antimicrobial stewardship team. Local protocols for antimicrobial therapy of surgical infections and protocols for surgical antibiotic prophylaxis were present in 76.6% and 90.8% of hospitals, respectively. In 23.4% and 24.0% of hospitals no surveillance systems for surgical site infections and no monitoring systems of used antimicrobials were implemented. Patient and family involvement in IPC management was considered to be slightly or not important in their hospital by the majority of respondents (65.1%). Awareness of the global burden of AMR among HCWs was considered very important or important by 54.6% of participants. The COVID-19 pandemic was considered by 80.3% of respondents as a very important or important factor in raising HCWs awareness of the IPC programs in their hospital. Based on the survey results, the authors developed 15 statements for several questions regarding the prevention and management of infections in surgery. The statements may be the starting point for designing future evidence-based recommendations. Conclusion Adequacy of prevention and management of infections in acute care facilities depends on HCWs behaviours and on the organizational characteristics of acute health care facilities to support best practices and promote behavioural change. Patient involvement in the implementation of IPC is still little considered. A debate on how operationalising a fundamental change to IPC, from being solely the HCWs responsibility to one that involves a collaborative relationship between HCWs and patients, should be opened.

Published
2022
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14. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

Author

Sartelli, aEmail Author, M., Baiocchi, bEmail Author, G. L., Saverio, Di, cEmail Author, S., Ferrara, dEmail Author, F., Labricciosa, eEmail Author, F. M., Ansaloni, fEmail Author, L., Coccolini, fEmail Author, F., Vijayan, gEmail Author, D., Abbas, hEmail Author, A., Abongwa, iEmail Author, H. K., Agboola, jEmail Author, J., Ahmed, kEmail Author, A., Akhmeteli, lEmail Author, L., Akkapulu, mEmail Author, N., Akkucuk, nEmail Author, S., Altintoprak, oEmail Author, F., Andreiev, gEmail Author, A. L., Anyfantakis, pEmail Author, D., Atanasov, qEmail Author, B., Bala, rEmail Author, M., Balalis, sEmail Author, D., Baraket, tEmail Author, O., Bellanova, uEmail Author, G., Beltran, vEmail Author, M., Melo, wEmail Author, R. B., Bini, xEmail Author, R., Bouliaris, yEmail Author, K., Brunelli, zEmail Author, D., Castillo, Mario, aaEmail Author, A., Catani, abEmail Author, M., Che, Jusoh, acEmail Author, A., Chichom-Mefire, adEmail Author, A., Cocorullo, aeEmail Author, G., Coimbra, afEmail Author, R., Colak, agEmail Author, E., Costa, ahEmail Author, S., Das, aiEmail Author, K., Delibegovic, ajEmail Author, S., Demetrashvili, akEmail Author, Z., Carlo, Di, alEmail Author, I., Kiseleva, amEmail Author, N., Zalabany, El, anEmail Author, T., Faro, aoEmail Author, M., Ferreira, apEmail Author, M., Fraga, aqEmail Author, G. P., Gachabayov, arEmail Author, M., Ghnnam, asEmail Author, W. M., Giménez, Maurel, atEmail Author, T., Gkiokas, auEmail Author, G., Gomes, avEmail Author, C. A., Griffiths, awEmail Author, E., Guner, axEmail Author, A., Gupta, ayEmail Author, S., Hecker, azEmail Author, A., Hirano, aqEmail Author, E. S., Hodonou, baEmail Author, A., Hutan, bbEmail Author, M., Ioannidis, Bc, O., Bdemail, Author, Isik, beEmail Author, A., Ivakhov, bfEmail Author, G., Jain, bgEmail Author, S., Jokubauskas, bhEmail Author, M., Karamarkovic, biEmail Author, A., Kauhanen, bjEmail Author, S., Kaushik, ayEmail Author, R., Kavalakat, bkEmail Author, A., Kenig, blEmail Author, J., Khokha, bmEmail Author, V., Khor, bnEmail Author, D., Kim, aaEmail Author, D., boEmail Author, J. I., Kong, bpEmail Author, V., Lasithiotakis, bqEmail Author, K., Leão, brEmail Author, P., Leon, bsEmail Author, M., Litvin, btEmail Author, A., Lohsiriwat, buEmail Author, V., López-Tomassetti, Fernandez, bvEmail Author, E., Lostoridis, bwEmail Author, E., Maciel, aaEmail Author, J., Major, bxEmail Author, P., Dimova, byEmail Author, A., Manatakis, bzEmail Author, D., Marinis, caEmail Author, A., Martinez-Perez, cbEmail Author, A., Marwah, ccEmail Author, S., Mcfarlane, Cd, M., Ceemail, Author, Mesina, cfEmail Author, C., Pȩdziwiatr, cgEmail Author, M., Michalopoulos, chEmail Author, N., Misiakos, ciEmail Author, E., Mohamedahmed, cjEmail Author, A., Moldovanu, ckEmail Author, R., Montori, fEmail Author, G., Mysore, Narayana, clEmail Author, R., Negoi, cmEmail Author, I., Nikolopoulos, cnEmail Author, I., Novelli, coEmail Author, G., Novikovs, amEmail Author, V., Olaoye, cpEmail Author, I., Omari, cqEmail Author, A., Ordoñez, crEmail Author, C. A., Ouadii, csEmail Author, M., Ozkan, ctEmail Author, Z., Pal, cuEmail Author, A., Palini, coEmail Author, G. M., Partecke, cvEmail Author, L. I., Pata, Francesco, cwEmail Author, F., cxEmail Author, M., Pereira, Júnior, cyEmail Author, G. A., Pintar, czEmail Author, T., Pisarska, daEmail Author, M., Ploneda-Valencia, dbEmail Author, C. F., Pouggouras, bwEmail Author, K., Prabhu, dcEmail Author, V., Ramakrishnapillai, ddEmail Author, P., Regimbeau, deEmail Author, J. -M., Reitz, dfEmail Author, M., Rios-Cruz, dgEmail Author, D., Saar, dhEmail Author, S., Sakakushev, diEmail Author, B., Seretis, djEmail Author, C., Sazhin, bfEmail Author, A., Shelat, dkEmail Author, V., Skrovina, dlEmail Author, M., Smirnov, dmEmail Author, D., Spyropoulos, dnEmail Author, C., Strzałka, doEmail Author, M., Talving, dhEmail Author, P., Teixeira, Gonsaga, dpEmail Author, R. A., Theobald, gEmail Author, G., Tomadze, dqEmail Author, G., Torba, drEmail Author, M., Tranà, aEmail Author, C., Ulrych, dsEmail Author, J., Uzunoğlu, nEmail Author, M. Y., Vasilescu, dtEmail Author, A., Occhionorelli, duEmail Author, S., Venara, dvEmail Author, A., Vereczkei, dwEmail Author, A., Vettoretto, dxEmail Author, N., Vlad, dtEmail Author, N., Walȩdziak, dyEmail Author, M., Yilmaz, dzEmail Author, T. U., Yuan, eaEmail Author, K. -C., Yunfeng, ebEmail Author, C., Zilinskas, bhEmail Author, J., Grelpois, deEmail Author, G., Catena, hEmail Author, F., Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Universidade do Minho, Sartelli M., Abu-Zidan F.M., Labricciosa F.M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A.W., Tolonen M., Trana C., Regimbeau J.-M., Hardcastle T., Koshy R.M., Abbas A., Aday U., Adesunkanmi A.R.K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A.B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A.C., Chiarugi M., Cillara N., Cuesta R.C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G.P., Gachabayov M., Gerard G., Ghnnam W., Maurel T.G., Gkiokas G., Gomes C.A., Guner A., Gupta S., Hecker A., Hirano E.S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J.I., Kong V., Korkolis D., Kruger V.F., Kshirsagar A., Simoes R.L., Lanaia A., Lasithiotakis K., Leao P., Arellano M.L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G.M., Major P., Manatakis D., Reitz M.M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F.G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G.-E., Occhionorelli S., Olaoye I., Ordonez C.A., Ozkan Z., Pal A., Palini G.M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G.A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R.A., Tochie J.N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M.Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A.I., Yalkin O., Yilmaz T.U., Unal A.E., Yuan K.-C., Zachariah S.K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G.L., Catena F., HUS Abdominal Center, II kirurgian klinikka, University of Helsinki, İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, and Altintoprak, Fatih

Subjects
Male, Medicina Básica [Ciências Médicas], 030230 surgery, Logistic regression, 0302 clinical medicine, Injury Severity Score, Interquartile range, Risk Factors, Antibiotics, Abdomen, Diagnosis, Acute peritonitis, Early warning score, Emergency surgery, Source control, Adult, Aged, Chi-Square Distribution, Female, Hospital Mortality, Humans, Logistic Models, Middle Aged, Sepsis, Prognosis, Mortality rate, Acute peritoniti, lcsh:Medical emergencies. Critical care. Intensive care. First aid, aarly warning score, acute peritonitis, emergency surgery, source control, abdomen, adult, aged, chi-square distribution, female, hospital mortality, humans, injury severity score, logistic models, male, middle aged, risk factors, sepsis, prognosis, 3. Good health, Management, Ciências Médicas::Medicina Básica, Emergency Medicine, Research Article, Human, medicine.medical_specialty, Logistic Model, Sepsi, lcsh:Surgery, NO, 03 medical and health sciences, Internal medicine, medicine, Acute appendicitis, Science & Technology, business.industry, Risk Factor, Surgery, lcsh:RD1-811, lcsh:RC86-88.9, 3126 Surgery, anesthesiology, intensive care, radiology, medicine.disease, Observational study, business, Chi-squared distribution, Kidney disease
Abstract

Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28–66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4–10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0–1, 22.7% for those who had scores of 2–3, 46.8% for those who had scores of 4–5, and 86.7% for those who have scores of 7–8. Conclusions The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.

Published
2019

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