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1. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Author: García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D’Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizabal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023
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2. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Author: Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León, Universidad de Salamanca, Banco Santander, Asociación Española Contra el Cáncer, Fundación CRIS contra el Cáncer, Fundación la Caixa, European Research Council, European Commission, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León, Universidad de Salamanca, Banco Santander, Asociación Española Contra el Cáncer, Fundación CRIS contra el Cáncer, Fundación la Caixa, European Research Council, European Commission, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Abstract: Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguanosine (m7G) transferase METTL1 is highly expressed in primary and advanced prostate tumours. Mechanistically, we find that METTL1 depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNAs steer translation control to favour the synthesis of key regulators of tumour growth suppression, interferon pathway, and immune effectors. Knockdown of Mettl1 in prostate cancer preclinical models increases intratumoural infiltration of pro-inflammatory immune cells and enhances responses to immunotherapy. Collectively, our findings reveal a therapeutically actionable role of METTL1-directed m7G tRNA methylation in cancer cell translation control and tumour biology.
Published: 2023

3. Additional file 10 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

4. Additional file 7 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

5. Additional file 8 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

6. Additional file 9 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

7. Additional file 2 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

8. Additional file 3 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

9. Additional file 4 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

10. Additional file 6 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

11. Additional file 5 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author: Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra
Published: 2023

12. Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN

Author: Ugalde-Olano, Aitziber, Egia, Ainara, Fernández-Ruiz, Sonia, Loizaga-Iriarte, Ana, Zuñiga-García, Patricia, Garcia, Stephane, Royo, Félix, Lacasa-Viscasillas, Isabel, Castro, Erika, Cortazar, Ana R., Zabala-Letona, Amaia, Martín-Martín, Natalia, Arruabarrena-Aristorena, Amaia, Torrano-Moya, Verónica, Valcárcel-Jiménez, Lorea, Sánchez-Mosquera, Pilar, Caro-Maldonado, Alfredo, González-Tampan, Jorge, Cachi-Fuentes, Guido, Bilbao, Elena, Montero, Rocío, Fernández, Sara, Arrieta, Edurne, Zorroza, Kerman, Castillo-Martín, Mireia, Serra, Violeta, Salazar, Eider, Macías-Cámara, Nuria, Tabernero, Jose, Baselga, Jose, Cordón-Cardo, Carlos, Aransay, Ana M., Villar, Amaia Del, Iovanna, Juan L., Falcón-Pérez, Juan M., Unda, Miguel, Bilbao, Roberto, and Carracedo, Arkaitz
Published: 2015
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13. Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer

Author: Valcarcel-Jimenez, Lorea, Macchia, Alice, Martín-Martín, Natalia, Cortazar, Ana Rosa, Schaub-Clerigué, Ariane, Pujana-Vaquerizo, Mikel, Fernández-Ruiz, Sonia, Lacasa-Viscasillas, Isabel, Santos-Martin, Aida, Loizaga-Iriarte, Ana, Unda-Urzaiz, Miguel, Hermanova, Ivana, Astobiza, Ianire, Graupera, Mariona, Starkova, Julia, Sutherland, James, Barrio, Rosa, Aransay, Ana M., Carracedo, Arkaitz, and Torrano, Verónica
Published: 2018
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14. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Author: Torrano, Veronica, Valcarcel-Jimenez, Lorea, Cortazar, Ana Rosa, Liu, Xiaojing, Urosevic, Jelena, Castillo-Martin, Mireia, Fernández-Ruiz, Sonia, Morciano, Giampaolo, Caro-Maldonado, Alfredo, Guiu, Marc, Zúñiga-García, Patricia, Graupera, Mariona, Bellmunt, Anna, Pandya, Pahini, Lorente, Mar, Martín-Martín, Natalia, Sutherland, James David, Sanchez-Mosquera, Pilar, Bozal-Basterra, Laura, Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Berenguer, Antonio, Embade, Nieves, Ugalde-Olano, Aitziber, Lacasa-Viscasillas, Isabel, Loizaga-Iriarte, Ana, Unda-Urzaiz, Miguel, Schultz, Nikolaus, Aransay, Ana Maria, Sanz-Moreno, Victoria, Barrio, Rosa, Velasco, Guillermo, Pinton, Paolo, Cordon-Cardo, Carlos, Locasale, Jason W., Gomis, Roger R., and Carracedo, Arkaitz
Published: 2016
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15. Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author: Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Martn-Martn, Natalia, Fernandez-Ruiz, Sonia, Sutherland, James D., Clasquin, Michelle, Tomas-Cortazar, Julen, Jimenez, Jose, Torres, Ines, Quang, Phong, Ximenez-Embun, Pilar, Bago, Ruzica, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Torrano, Vernica, Cabrera, Diana, van Liempd, Sebastiaan M., Cendon, Ylenia, Castro, Elena, Murray, Stuart, Revandkar, Ajinkya, Alimonti, Andrea, Zhang, Yinan, Barnett, Amelia, Lein, Gina, Pirman, David, Cortazar, Ana R., Arreal, Leire, Prudkin, Ludmila, Astobiza, Ianire, Valcarcel-Jimenez, Lorea, Zuiga-Garca, Patricia, Fernandez-Dominguez, Itziar, Piva, Marco, Caro-Maldonado, Alfredo, Snchez-Mosquera, Pilar, Castillo-Martn, Mireia, Serra, Violeta, Beraza, Naiara, Gentilella, Antonio, Thomas, George, Azkargorta, Mikel, Elortza, Felix, Farrs, Rosa, Olmos, David, Efeyan, Alejo, Anguita, Juan, Muoz, Javier, Falcn-Prez, Juan M., Barrio, Rosa, Macarulla, Teresa, Mato, Jose M., Martinez-Chantar, Maria L., Cordon-Cardo, Carlos, Aransay, Ana M., Marks, Kevin, Baselga, Jos, Tabernero, Josep, Nuciforo, Paolo, Manning, Brendan D., Marjon, Katya, and Carracedo, Arkaitz
Subjects: Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Author(s): Amaia Zabala-Letona; Amaia Arruabarrena-Aristorena; Natalia Martn-Martn; Sonia Fernandez-Ruiz; James D. Sutherland; Michelle Clasquin; Julen Tomas-Cortazar; Jose Jimenez; Ines Torres; Phong Quang; Pilar Ximenez-Embun; Ruzica Bago; Aitziber Ugalde-Olano; Ana Loizaga-Iriarte; [...]
Published: 2018
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16. Tratamiento actual de las masas renales pequeñas

Author: José Iriarte Soldevilla, I., Senarriaga Ruiz de la Illa, Nerea, Lacasa Viscasillas, Isabel, Loizaga Iriarte, Ana, Zubiaur Libano, Carmen, and Unda Urzaiz, Miguel
Published: 2009
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17. mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author: Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Martn-Martn, Natalia, Fernandez-Ruiz, Sonia, Sutherland, James D., Clasquin, Michelle, Tomas-Cortazar, Julen, Jimenez, Jose, Torres, Ines, Quang, Phong, Ximenez-Embun, Pilar, Bago, Ruzica, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Torrano, Vernica, Cabrera, Diana, van Liempd, Sebastiaan M., Cendon, Ylenia, Castro, Elena, Murray, Stuart, Revandkar, Ajinkya, Alimonti, Andrea, Zhang, Yinan, Barnett, Amelia, Lein, Gina, Pirman, David, Cortazar, Ana R., Arreal, Leire, Prudkin, Ludmila, Astobiza, Ianire, Valcarcel-Jimenez, Lorea, Zuiga-Garca, Patricia, Fernandez-Dominguez, Itziar, Piva, Marco, Caro-Maldonado, Alfredo, Snchez-Mosquera, Pilar, Castillo-Martn, Mireia, Serra, Violeta, Beraza, Naiara, Gentilella, Antonio, Thomas, George, Azkargorta, Mikel, Elortza, Felix, Farrs, Rosa, Olmos, David, Efeyan, Alejo, Anguita, Juan, Muoz, Javier, Falcn-Prez, Juan M., Barrio, Rosa, Macarulla, Teresa, Mato, Jose M., Martinez-Chantar, Maria L., Cordon-Cardo, Carlos, Aransay, Ana M., Marks, Kevin, Baselga, Jos, Tabernero, Josep, Nuciforo, Paolo, Manning, Brendan D., Marjon, Katya, and Carracedo, Arkaitz
Subjects: Polyamines -- Physiological aspects, Prostate cancer -- Physiological aspects, S-adenosylmethionine -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Author(s): Amaia Zabala-Letona [1, 2]; Amaia Arruabarrena-Aristorena [1]; Natalia Martn-Martn [1, 2]; Sonia Fernandez-Ruiz [1, 2]; James D. Sutherland [1]; Michelle Clasquin [3]; Julen Tomas-Cortazar [1]; Jose Jimenez [4]; Ines [...]
Published: 2017
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18. Integrative analysis of transcriptomic and clinical data uncovers the tumor suppressive activity of MITF in prostate cancer

Author: Valcarcel-Jimenez, Lorea, primary, Macchia, Alice, additional, Martín-Martín, Natalia, additional, Cortazar, Ana Rosa, additional, Schaub-Clerigué, Ariane, additional, Pujana-Vaquerizo, Mikel, additional, Fernández-Ruiz, Sonia, additional, Lacasa-Viscasillas, Isabel, additional, Santos-Martin, Aida, additional, Loizaga-Iriarte, Ana, additional, Unda-Urzaiz, Miguel, additional, Hermanova, Ivana, additional, Astobiza, lanire, additional, Graupera, Mariona, additional, Starkova, Julia, additional, Sutherland, James, additional, Barrio, Rosa, additional, Aransay, Ana M., additional, Carracedo, Arkaitz, additional, and Torrano, Verónica, additional
Published: 2018
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19. Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

Author: Clos-Garcia, Marc, primary, Loizaga-Iriarte, Ana, additional, Zuñiga-Garcia, Patricia, additional, Sánchez-Mosquera, Pilar, additional, Rosa Cortazar, Ana, additional, González, Esperanza, additional, Torrano, Verónica, additional, Alonso, Cristina, additional, Pérez-Cormenzana, Miriam, additional, Ugalde-Olano, Aitziber, additional, Lacasa-Viscasillas, Isabel, additional, Castro, Azucena, additional, Royo, Felix, additional, Unda, Miguel, additional, Carracedo, Arkaitz, additional, and Falcón-Pérez, Juan M., additional
Published: 2018
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20. Integrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Cancer

Author: Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Valcárcel Jiménez, Lorea, Macchia, Alice, Martín Martín, Natalia, Cortazar, Ana Rosa, Schaub Clerigué, Ariane, Pujana Vaquerizo, Mikel, Fernández Ruiz, Sonia, Lacasa Viscasillas, Isabel, Santos Martín, Aida, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Hermanova, Ivana, Astobiza Pérez, Janire, Graupera, Mariona, Julia, Starkova, Sutherland, James D., Barrio Olano, María Rosa, Aransay Bañares, Ana María, Carracedo Pérez, Arkaitz, Torrano Moya, Verónica, Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Valcárcel Jiménez, Lorea, Macchia, Alice, Martín Martín, Natalia, Cortazar, Ana Rosa, Schaub Clerigué, Ariane, Pujana Vaquerizo, Mikel, Fernández Ruiz, Sonia, Lacasa Viscasillas, Isabel, Santos Martín, Aida, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Hermanova, Ivana, Astobiza Pérez, Janire, Graupera, Mariona, Julia, Starkova, Sutherland, James D., Barrio Olano, María Rosa, Aransay Bañares, Ana María, Carracedo Pérez, Arkaitz, and Torrano Moya, Verónica
Abstract: The dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity to identify core regulators of the tumorigenic process. Here we exploit well-annotated clinical datasets of prostate cancer for the discovery of transcriptional regulators relevant to prostate cancer. Following this rationale, we identify Microphthalmia-associated transcription factor (MITF) as a prostate tumor suppressor among a subset of transcription factors. Importantly, we further interrogate transcriptomics and clinical data to refine MITF perturbation-based empirical assays and unveil Crystallin Alpha B (CRYAB) as an unprecedented direct target of the transcription factor that is, at least in part, responsible for its tumor-suppressive activity in prostate cancer. This evidence was supported by the enhanced prognostic potential of a signature based on the concomitant alteration of MITF and CRYAB in prostate cancer patients. In sum, our study provides proof-of-concept evidence of the potential of the bioinformatics screen of publicly available cancer patient databases as discovery platforms, and demonstrates that the MITF-CRYAB axis controls prostate cancer biology.
Published: 2018

21. Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

Author: Bioquímica y biología molecular, Biokimika eta biologia molekularra, Clos-Garcia, Marc, Loizaga Iriarte, Ana, Zuñiga García, Patricia, Sánchez Mosquera, Pilar, Cortázar, Ana Rosa, González, Esperanza, Verónica Torrano, Alonso, Cristina, Pérez Cormenzana, Miriam, Ugalde Olano, Aitziber, Lacasa Viscasillas, Isabel, Castro, Azucena, Royo, Félix, Unda Urzaiz, Jesús Miguel, Carracedo Pérez, Arkaitz, Falcón Pérez, Juan Manuel, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Clos-Garcia, Marc, Loizaga Iriarte, Ana, Zuñiga García, Patricia, Sánchez Mosquera, Pilar, Cortázar, Ana Rosa, González, Esperanza, Verónica Torrano, Alonso, Cristina, Pérez Cormenzana, Miriam, Ugalde Olano, Aitziber, Lacasa Viscasillas, Isabel, Castro, Azucena, Royo, Félix, Unda Urzaiz, Jesús Miguel, Carracedo Pérez, Arkaitz, and Falcón Pérez, Juan Manuel
Abstract: Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have previously identified proteins and RNAs with differential abundance in urinary EVs from prostate cancer (PCa) patients compared to benign prostate hyperplasia (BPH). Here, we focused on the analysis of the metabolites contained in urinary EVs collected from patients with PCa and BPH. Targeted metabolomics analysis of EVs was performed by ultrahigh- performance liquid chromatography-mass spectrometry. The correlation between metabolites and clinical parameters was studied, and metabolites with differential abundance in PCa urinary EVs were detected and mapped into cellular pathways. We detected 248 metabolites belonging to different chemical families including amino acids and various lipid species. Among these metabolites, 76 exhibited significant differential abundance between PCa and BPH. Interestingly, urine EVs recapitulated many of the metabolic alterations reported in PCa, including phosphathidylcholines, acyl carnitines, citrate and kynurenine. Importantly, we found elevated levels of the steroid hormone, 3beta-hydroxyandros-5-en-17-one-3-sulphate (dehydroepiandrosterone sulphate) in PCa urinary EVs, in line with the potential elevation of androgen synthesis in this type of cancer. This work supports urinary EVs as a non-invasive source to infer metabolic changes in PCa.
Published: 2018

22. Erratum: Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author: Zabala-Letona, Amaia, primary, Arruabarrena-Aristorena, Amaia, additional, Martín-Martín, Natalia, additional, Fernandez-Ruiz, Sonia, additional, Sutherland, James D., additional, Clasquin, Michelle, additional, Tomas-Cortazar, Julen, additional, Jimenez, Jose, additional, Torres, Ines, additional, Quang, Phong, additional, Ximenez-Embun, Pilar, additional, Bago, Ruzica, additional, Ugalde-Olano, Aitziber, additional, Loizaga-Iriarte, Ana, additional, Lacasa-Viscasillas, Isabel, additional, Unda, Miguel, additional, Torrano, Verónica, additional, Cabrera, Diana, additional, van Liempd, Sebastiaan M., additional, Cendon, Ylenia, additional, Castro, Elena, additional, Murray, Stuart, additional, Revandkar, Ajinkya, additional, Alimonti, Andrea, additional, Zhang, Yinan, additional, Barnett, Amelia, additional, Lein, Gina, additional, Pirman, David, additional, Cortazar, Ana R., additional, Arreal, Leire, additional, Prudkin, Ludmila, additional, Astobiza, Ianire, additional, Valcarcel-Jimenez, Lorea, additional, Zuñiga-García, Patricia, additional, Fernandez-Dominguez, Itziar, additional, Piva, Marco, additional, Caro-Maldonado, Alfredo, additional, Sánchez-Mosquera, Pilar, additional, Castillo-Martín, Mireia, additional, Serra, Violeta, additional, Beraza, Naiara, additional, Gentilella, Antonio, additional, Thomas, George, additional, Azkargorta, Mikel, additional, Elortza, Felix, additional, Farràs, Rosa, additional, Olmos, David, additional, Efeyan, Alejo, additional, Anguita, Juan, additional, Muñoz, Javier, additional, Falcón-Pérez, Juan M., additional, Barrio, Rosa, additional, Macarulla, Teresa, additional, Mato, Jose M., additional, Martinez-Chantar, Maria L., additional, Cordon-Cardo, Carlos, additional, Aransay, Ana M., additional, Marks, Kevin, additional, Baselga, José, additional, Tabernero, Josep, additional, Nuciforo, Paolo, additional, Manning, Brendan D., additional, Marjon, Katya, additional, and Carracedo, Arkaitz, additional
Published: 2018
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23. Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Author: Torrano, Veronica, primary, Valcarcel-Jimenez, Lorea, additional, Cortazar, Ana Rosa, additional, Liu, Xiaojing, additional, Urosevic, Jelena, additional, Castillo-Martin, Mireia, additional, Fernández-Ruiz, Sonia, additional, Morciano, Giampaolo, additional, Caro-Maldonado, Alfredo, additional, Guiu, Marc, additional, Zúñiga-García, Patricia, additional, Graupera, Mariona, additional, Bellmunt, Anna, additional, Pandya, Pahini, additional, Lorente, Mar, additional, Martín-Martín, Natalia, additional, Sutherland, James David, additional, Sanchez-Mosquera, Pilar, additional, Bozal-Basterra, Laura, additional, Zabala-Letona, Amaia, additional, Arruabarrena-Aristorena, Amaia, additional, Berenguer, Antonio, additional, Embade, Nieves, additional, Ugalde-Olano, Aitziber, additional, Lacasa-Viscasillas, Isabel, additional, Loizaga-Iriarte, Ana, additional, Unda-Urzaiz, Miguel, additional, Schultz, Nikolaus, additional, Aransay, Ana Maria, additional, Sanz-Moreno, Victoria, additional, Barrio, Rosa, additional, Velasco, Guillermo, additional, Pinton, Paolo, additional, Cordon-Cardo, Carlos, additional, Locasale, Jason W., additional, Gomis, Roger R., additional, and Carracedo, Arkaitz, additional
Published: 2017
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24. RADIO 223 EN CÁNCER DE PRÓSTATA RESISTENTE A LA CASTRACIÓN.

Author: Loizaga-Iriarte, Ana, Ibargarai, Isabel Camargo, de la Illa, Nerea Senarriaga-Ruiz, Lacasa-Viscasillas, Isabel, and Unda-Urzaiz, Miguel
Published: 2018

25. Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer

Author: Royo, Felix, primary, Zuñiga-Garcia, Patricia, additional, Torrano, Verónica, additional, Loizaga, Ana, additional, Sanchez-Mosquera, Pilar, additional, Ugalde-Olano, Aitziber, additional, González, Esperanza, additional, Cortazar, Ana R., additional, Palomo, Laura, additional, Fernández-Ruiz, Sonia, additional, Lacasa-Viscasillas, Isabel, additional, Berdasco, Maria, additional, Sutherland, James D., additional, Barrio, Rosa, additional, Zabala-Letona, Amaia, additional, Martín-Martín, Natalia, additional, Arruabarrena-Aristorena, Amaia, additional, Valcarcel-Jimenez, Lorea, additional, Caro-Maldonado, Alfredo, additional, Gonzalez-Tampan, Jorge, additional, Cachi-Fuentes, Guido, additional, Esteller, Manel, additional, Aransay, Ana M., additional, Unda, Miguel, additional, Falcón-Pérez, Juan M., additional, and Carracedo, Arkaitz, additional
Published: 2016
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26. Hidatidosis pelviana como ejemplo de masas pelvianas de etiología dudosa

Author: Senarriaga Ruiz de la Illa, Nerea, Loizaga Iriarte, Ana, Iriarte Soldevilla, Iñaki, Lacasa Viscasillas, Isabel, and Unda Urzaiz, Miguel
Subjects: Equinococo, Hydatid cyst, Riñón, Quiste hidatídico, Kidney, Echinococcal, Pelvis
Abstract: Presentar dos nuevos casos de quiste hidatídico pelviano, uno con clínica de compresión local y otro asintomático. Varón de 75 años que refiere tenesmo, dificultad para la micción y defecación. Una ecografía revela que se trata de una gran masa quística pelviana que desplaza la vejiga y el rectosigma. La tomografía computarizada describe imágenes compatibles con hidatidosis y un quiste hidatídico hepático. Se interviene quirúrgicamente al paciente, y se extirpa parcialmente el quiste pelviano. El otro caso es un varón de 75 años que, en el estudio de HBP, se descubre de forma casual una hidatidosis pelviana. Se decide, al estar asintomático, vigilancia. La anatomía patológica confirma el diagnóstico en el primer caso y los hallazgos radiológicos, en el segundo. Ambos pacientes están asintomáticos. La posibilidad de hidatidosis se debe considerar en el diagnóstico diferencial de cualquier masa quística localizada en los órganos pelvianos, sobre todo en países donde la enfermedad es endémica. Aunque no hay un test serológico con el 100% de especificidad, las pruebas radiológicas ayudan a confirmar el diagnóstico. La cirugía es el tratamiento de elección. We present two new cases of pelvic hydatid cysts, one with a clinical profile of local compression and the other one asymptomatic. The first case is a 75 year-old man who reported difficulty defecating and urinating. The ultrasound revealed a large cystic pelvic mass displacing the bladder and rectosigmoid region. Computed tomography also showed images compatible with hydatid disease and a hydatid liver cyst. The patient underwent a surgical procedure, and the pelvic cyst was partially excised. The other case is an asymptomatic 75 year-old man with pelvic hydatid disease that was discovered by chance while examining a prostatic adenoma. Because he is asymptomatic, we opted for observation. The anatomical pathology study confirmed the diagnosis in the first case and radiological findings confirmed the second. Both patients remain asymptomatic. Hydatid disease must be considered in the differential diagnosis for any cystic masses in the pelvic organs, especially in countries where the disease is endemic. Although no 100% specific serological test exists, there are some radiological procedures which can help us to confirm the disease. Surgery is the treatment of choice.
Published: 2009

27. New case of an infrarenal abdominal aortic aneurysm associated with horseshoe kidney

Author: Senarriaga Ruiz de la Illa, Nerea, Vega Manrique, Reyes, Lacasa Viscasillas, Isabel, Iriarte Soldevilla, Iñaki, and Unda Urzaiz, Miguel
Subjects: Aneurisma aórtico, Aortic aneurysm, Horseshoe kidney, Abordaje retroperitoneal, Retroperitoneal approach, cardiovascular system, Riñón en herradura
Abstract: Se analiza la relación entre enfermedad aórtica quirúrgica y riñón en herradura, y se comentan los problemas diagnósticos y las diferentes posibilidades terapéuticas. Paciente de 81 años con riñones en herradura que, durante el seguimiento de su enfermedad prostática, se descubre de forma casual por ecografía un aneurisma de aorta abdominal. Se realizó mediante abordaje retroperitoneal una resección del aneurisma y bypass aortoaórtico, sin complicaciones. A los 2 años del diagnóstico, el paciente continúa asintomático en cuanto a la alteración vascular. La coexistencia de riñón en herradura y afección aórtica que precise corrección quirúrgica ocurre con poca frecuencia, pero incrementa de forma significativa la complejidad técnica de la reconstrucción aórtica. Se realiza una revisión de la literatura. We review the association between surgically resolvable aortic disease and horseshoe kidney with a discussion of diagnostic problems and therapeutic options. Male patient 81 years of age with horseshoe kidney and an abdominal aortic aneurysm that was discovered by chance in an abdominal ultrasound during a check-up for his prostate condition. A retroperitoneal approach was used in order to resect the aneurysm and perform an aorto-aortic bypass with no complications occurring. Two years after the diagnosis, the patient is still asymptomatic from a vascular point of view. The co-presence of horseshoe kidney and aortic disease needing surgical correction is infrequent, but it significantly increases the technical complexity of aortic reconstruction. A literature review is included.
Published: 2009

28. Aneurismas de aorta inflamatorios y su relación con la patología urológica: caso clínico y revisión de la literatura científica

Author: Senarriaga Ruiz de la Illa, Nerea, Vega Manrique, Reyes, Lacasa Viscasillas, Isabel, Arciniega García, Jesús María, and Unda Urzaiz, Miguel
Subjects: Inflammatory aneurysm, Sintomático, Symptomatic, Morbidity and mortality, Aneurisma inflamatorio, Morbimortalidad
Abstract: Objetivo: Presentamos un caso de aneurisma aórtico inflamatorio resuelto con éxito. Material y métodos: Paciente de 57 años que consulta por dolor lumbar e infecciones urinarias. Se realiza una angio-TC y se descubre un aneurisma de aorta abdominal inflamatorio de gran tamaño. Se interviene quirúrgicamente, realizando un bypass aortoaórtico, sin complicaciones intraoperatorias. Resultados: El paciente evoluciona favorablemente desde la cirugía; en la actualidad, se encuentra asintomático. Conclusiones: La participación del equipo de radiología, fundamentalmente con el angio-TC, es de gran valor, tanto para el establecimiento de un diagnóstico diferencial, como para un tratamiento y seguimiento correctos. La cirugía está indicada para prevenir la rotura de estos aneurismas, asumiendo un incremento en la morbimortalidad postoperatoria. Objective: To report a successfully treated case of inflammatory aortic aneurysm. Materials and methods: A 57-year-old patient reported low back pain and urinary infections. An abdominal CT scan revealed a large inflammatory aneurysm in the abdominal aorta. An aortic bypass was performed with no complications. Results: Patient course since surgery has been uneventful, and currently has no symptoms. Conclusions: Contribution of the radiographic team, mainly with the CT scan, is of great value both for differential diagnosis and adequate management and follow-up. Surgery is indicated to prevent aneurysm rupture, but an increased postoperative morbidity and mortality should be assumed.
Published: 2009

29. ¿Implica el T0 en la pieza de cistectomía encontrarse libre de tumor a largo plazo?

Author: Loizaga Iriarte, Ana, Senarriaga Ruiz de la Illa, Nerea, Lacasa Viscasillas, Isabel, Rábade Ferreiro, Ainara, Iriarte Soldevilla, Iñaki, and Unda Urzaiz, Miguel
Subjects: Cáncer de vejiga, Pronóstico, Cistectomía, pT0N0, Bladder tumour, Cystectomy, Prognosis
Abstract: Introducción y objetivos: El objetivo de este estudio fue evaluar la evolución de los pacientes que presentaban un T0 en la pieza de cistectomía para conocer posibles factores que nos ayuden a decidir cuándo hacer preservación vesical. Material y métodos: Revisamos 153 cistectomías radicales realizadas por tumor vesical y sin tratamiento neoadyuvante en nuestro centro entre 1995 y 2005, con un seguimiento mínimo de 3 años. Seleccionamos los pacientes con pT0N0. Se tuvieron en cuenta la edad al diagnóstico, el sexo, el estadio y el grado patológico de la resección transuretral (RTU), número de resecciones, características del tumor (multifocalidad, papilar o sólido), tiempo libre de progresión, supervivencia libre de enfermedad y causa de muerte. Realizamos un análisis univariado de los diversos factores estudiados con la progresión de la enfermedad. Resultados: Un 12,8% de las piezas de cistectomías fueron T0N0. La progresión ocurrió en un 35% en un plazo de entre 6 meses y 4 años después de la cistectomía. La supervivencia cáncer específica fue del 75%; 5 pacientes murieron en una media de 18 meses. La causa de la muerte fue en todos ellos progresión tumoral con metástasis a distancia. Los estudios estadísticos en un análisis univariado sólo relacionaban con progresión, el número de RTU previas, probablemente debido al tamaño muestral, aunque la multifocalidad y el grado y el estadio tumoral resultaban destacables. Un 15% de los pacientes con pT0 tenían un fenotipo papilar, y de ellos un 33% murieron. Con fenotipo no papilar murieron un 23,5%. Conclusiones: Un pT0N0 en la pieza de cistectomía no define esta cirugía como curativa y nos exige un seguimiento del paciente similar al resto. Es de destacar que no hubo recurrencia local en nuestros casos, sino metástasis a distancia, lo que nos hace pensar que estos pacientes podían haberse beneficiado de un tratamiento con quimioterapia sistémica sin requerir cirugía radical. En nuestra serie, el número de recidivas previas fue el único factor pronóstico con significación estadística. Introduction and objectives: The aim of this study was to evaluate the progress of patients with a pT0 radical cystectomy specimen in order to know what factors are helpful in deciding when the bladder can be preserved. Material and methods: We reviewed 153 cases of radical cystectomies performed due to bladder tumours without neoadjuvant therapy between 1995 and 2005 and with a minimum of three years of follow-up. Stage pT0 patients were selected. We considered age at time of diagnosis, sex, pathological stage and grade of the tumour at the time of transurethral resection (TUR), number of resections, surgical factors, tumour characteristics (multifocal, papillary or solid), progression-free survival, cancer-specific survival and cause of death. We ran a univariate analysis of the different factors studied along with disease progression. Results: 12.8% of cystectomy specimens were pT0N0. Progression occurred in 35% between 6 months and 4 years after the cystectomy. Cancer-specific survival was 75%. Five patients died within an average of 18 months. The cause of death for all of them was tumour progression with distant metastasis. Statistical studies in the univariate analysis were only related to progression and the number of prior TURs, which is probably due to the number of cases, but the tumour multifocality, grade and stage were noteworthy. 15% of the pT0 patients had a papillary phenotype and 33% of them died. Of those with a non-papillary phenotype, 23.5% died. Conclusions: A stage pT0N0 cystectomy specimen does not define this surgery as curative, and these cases require the same follow-up as for the rest of the patients. It is of particular interest that out of all of our cases, there was no local recurrence, but there was distant metastasis. This leads us to believe that these patients could have benefitted from systemic chemotherapy with no need for radical surgery. In our study, the number of previous relapses was the only prognostic factor with statistical significance.
Published: 2009

30. Tratamiento actual de las masas renales pequeñas

Author: Iriarte Soldevilla, José I., Senarriaga Ruiz de la Illa, Nerea, Lacasa Viscasillas, Isabel, Loizaga Iriarte, Ana, Zubiaur Libano, Carmen, and Unda Urzaiz, Miguel
Subjects: Crioterapia, Cryotherapy, Radiofrecuencia, Renal carcinoma, Radiofrequency, Vigilancia Activa, Carcinoma Renal, Active surveillance
Abstract: Cada día son diagnosticados con más frecuencia de manera incidental Carcinomas Renales (CR), debido al aumento del uso de las técnicas de Radiodiagnóstico para el estudio de otras patologías. Su incidencia en los países desarrollados es superior al 40%, siendo malignos el 80% de los tumores sólidos de riñón menores de 4cm. El tratamiento estándar de este tipo de tumores es la nefrectomía parcial con un índice de recidivas del 1-2%. El mayor incremento en el diagnostico de esta patología se ha producido en pacientes entre los 70 y 90 años, grupo de edad que se acompaña de gran numero de comorbilidades. En las dos ultimas décadas y acompañando al desarrollo de las técnicas radiológicas, se han establecido entre nosotros dos técnicas, ablativas, que a través del frío, la Crioterapia (CA), y a través del calor, la Radiofrecuencia (RFA), consiguen la necrosis del tumor. Los resultados oncológicos a corto y medio plazo alcanzan un 95% de remisiones en tumores menores de 4 cm. y al ser técnicas que se pueden realizar por vía percutánea, tanto las complicaciones como las estancias hospitalarias han disminuido. Ya en 1995 Bosniak basándose en la experiencia de la observación del crecimiento y conducta de los CR pequeños durante más de 8 años propugna la postura de “Esperar y Ver” o “Vigilancia Activa”(VA). Presentamos la CA, nuestra serie de RAF y revisamos la literatura de la VA. Conclusiones: En pacientes con edad avanzada, enfermedades concomitantes que desaconsejen la cirugía, monorrenos, con tumores renales múltiples o pacientes que rechacen la cirugía, las técnicas ablativas pueden ser utilizadas de manera segura y eficaz en manos expertas, alcanzando a medio plazo resultados oncológicos similares a la nefrectomía parcial, del mismo modo que en pacientes correctamente informados la vigilancia activa se ha demostrado como segura a medio plazo. Para mejorar las indicaciones, serán necesarias nuevas técnicas diagnósticas, que nos ayuden a diferenciar los tumores potencialmente más agresivos de los que no se van a desarrollar y series mayores y con más años de evolución para confirmar los resultados actuales. Incidental diagnosis of renal carcinoma (RC) is increasingly common due to widespread use of radiodiagnostic techniques for other conditions. In developed countries, incidental tumor account for more than 40% of detected tumors, and 80% of solid kidney tumors less than 4 cm in size are malignant. Standard treatment for these tumors is partial nephrectomy, and their relapse rate is 1%-2% The higher increase in diagnosis of this disease has occurred in patients aged 70 to 90 years, a group where associated comorbidities are very common. In the past two decades, in parallel to development of radiographic techniques, two ablation procedures achieving tumor necrosis through cold, cryotherapy, and through heat, radiofrequency, have become established. These procedures achieve 95% short- and long-term remissions in tumors less than 4 cm in size. In addition, since these procedures may be performed percutaneously, both complications and hospital stay have decreased. As early as in 1995, Bosniak, based on observation of the growth and behavior of small RCs for longer than 8 years, advocated a watchful waiting or active surveillance attitude. This article reports cryotherapy, our radiofrequency series, and a literature review. Conclusions: In the event of elderly patients, concomitant diseases advising against surgery, multiple renal tumors, a solitary kidney, or patients who reject surgery, ablation procedures may be safe and effective when performed by expert hands, achieving mid-term oncological results similar to partial nephrectomy. Active surveillance has also been shown to be safe in the mid-term in adequately informed patients. To improve indications, new diagnostic procedures that help us differentiate the potentially more aggressive tumors will be required. Larger series and longer follow-ups are neede to confirm current results.
Published: 2009

31. Carcinoma ductal del utrículo prostático: Caso clínico y revisión de la literatura

Author: Senarriaga Ruiz de la Illa, Nerea, Loizaga Iriarte, Ana, Larrinaga Izaguirre, José Ramón, Lacasa Viscasillas, Isabel, Arciniega García, Jesús María, and Unda Urzaiz, Miguel
Subjects: Utrículo prostático, Utricle, Ductal carcinoma, Carcinoma ductal, Prostate, Obstrucción urinaria, Próstata, Urinary obstruction
Abstract: Objetivo: Se presenta un caso de adenocarcinoma ductal prostático, anteriormente conocido como carcinoma endometrioide y se revisa la literatura. Métodos: Paciente de 75 años que acude a la consulta por sintomatología de obstrucción urinaria, PSA de 8,1 ng/ml., sin otra clínica acompañante. El tacto rectal y la ecografía abdominopélvica evidencian una próstata pequeña y pétrea. Se realiza resección transuretral desobstructiva y la anatomía patológica revela carcinoma ductal del utrículo prostático. Resultados: A los 9 años del diagnóstico no presenta signos de diseminación. Conclusiones: De hallazgo casual en el estudio anatomo-patológico, el adenocarcinoma ductal del utrículo prostático es una rara neoformación, cuya incidencia entre todos los carcinomas prostáticos ha sido citada entre 0,2 - 0,8%, si bien resulta interesante hacer una revisión sobre el tema para fomentar su estudio. Se revisan la clínica, diagnóstico y tratamiento de dicho carcinoma. Objective: A case of ductal carcinoma of the prostatic utricle is described, previously known as endometrial carcinoma, and literature is reviewed. Methods: 75 years old patient who consults for lower urinary tract obstructive symptoms, with a PSA of 8.1 ng/ml., without more symptoms. Digital rectal examination and ultrasound showed a small and stony prostate. Deobstructive transurethral resection of the prostate was performed and the biopsy revealed ductal carcinoma of the utricle. Results: Nine years after diagnosis signs of dissemination are not present. Conclusions: As incidental finding in the biopsy, ductal carcinoma of the utricle is a rare tumor, the incidence of which among all prostatic carcinomas has been cited as 0.2 - 0.8%. We report a review about this topic for improving its knowledge. Symptoms, pathological findings and treatment of this carcinoma have been reviewed.
Published: 2008

32. Aneurisma de aorta abdominal infrarrenal en asociación con riñón en herradura: aportación de un caso

Author: Senarriaga Ruiz de la Illa, Nerea, primary, Vega Manrique, Reyes, additional, Lacasa Viscasillas, Isabel, additional, Iriarte Soldevilla, Iñaki, additional, and Unda Urzaiz, Miguel, additional
Published: 2009
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33. Hidatidosis pelviana como ejemplo de masas pelvianas de etiología dudosa

Author: Senarriaga Ruiz de la Illa, Nerea, primary, Loizaga Iriarte, Ana, additional, Iriarte Soldevilla, Iñaki, additional, Lacasa Viscasillas, Isabel, additional, and Unda Urzaiz, Miguel, additional
Published: 2009
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34. ¿Implica el T0 en la pieza de cistectomía encontrarse libre de tumor a largo plazo?

Author: Loizaga Iriarte, Ana, primary, Senarriaga Ruiz de la Illa, Nerea, additional, Lacasa Viscasillas, Isabel, additional, Rábade Ferreiro, Ainara, additional, Iriarte Soldevilla, Iñaki, additional, and Unda Urzaiz, Miguel, additional
Published: 2009
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35. Tratamiento actual de las masas renales pequeñas

Author: Iriarte Soldevilla, José I., primary, Senarriaga Ruiz de la Illa, Nerea, additional, Lacasa Viscasillas, Isabel, additional, Loizaga Iriarte, Ana, additional, Zubiaur Libano, Carmen, additional, and Unda Urzaiz, Miguel, additional
Published: 2009
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36. Carcinoma ductal del utrículo prostático: Caso clínico y revisión de la literatura

Author: Senarriaga Ruiz de la Illa, Nerea, primary, Loizaga Iriarte, Ana, additional, Larrinaga Izaguirre, José Ramón, additional, Lacasa Viscasillas, Isabel, additional, Arciniega García, Jesús María, additional, and Unda Urzaiz, Miguel, additional
Published: 2008
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37. [Radium 223 in castration resistant prostate cancer.]

Author: Loizaga-Iriarte A, Camargo Ibargarai I, Senarriaga-Ruiz de la Illa N, Lacasa-Viscasillas I, and Unda-Urzaiz M
Subjects: Forecasting, Humans, Male, Radioisotopes therapeutic use, Antineoplastic Agents therapeutic use, Bone Neoplasms drug therapy, Bone Neoplasms secondary, Prostatic Neoplasms, Castration-Resistant drug therapy, Prostatic Neoplasms, Castration-Resistant pathology, Radium therapeutic use
Abstract: Objective: To analyze the available evidence on Radium 223 therapy, an alfa particle emitter with specific action on bone metastases, studied on patients with castration resistant prostate cancer., Evidence Acquisition: We review the pivotal study ALSYMPCA, that served to get the drug approval for this phase of the disease, and the new data obtained from its use. We also performed a search of ongoing studies with Radium 223 alone or in combination with other molecules., Evidence Sinthesis: According to the ALSYMPCA study, Radium 223 significantly prolongs the overall survival of patients with castration resistant prostate cancer and bone metastases; approximately 3.6 months in comparison with patients who received placebo, which turns into a median life expectancy of 14.9 months, and a 36-month survival of 46%, associated with a 30% reduction in death risk. Overall survival results were consistent both in patients who receive Docetaxel previously and those who did not., Results: for secondary variables support the positive effect of Radium 223 therapy on symptomatic skeletal events (for example, the use of external beam radiotherapy to alleviate pain) and bone markers, confirming its efficacy in bone metastases., Conclusions: Radium 223 is the first treatment directed to bone that has demonstrated significant improvement on overall survival. It also prolonged the time to the first skeletal event and the median time to PSA increase significantly. All this in addition to its manageable adverse effects, lower than those appeared in the placebo arm of the pivotal study ALSYMPCA.
Published: 2018

38. Pelvic hydatid disease as an example of pelvic masses of uncertain aetiology.

Author: Senarriaga Ruiz de la Illa N, Loizaga Iriarte A, Iriarte Soldevilla I, Lacasa Viscasillas I, and Unda Urzaiz M
Subjects: Aged, Echinococcosis surgery, Humans, Male, Pelvis, Echinococcosis diagnosis
Abstract: We describe two new cases of pelvic hydatid cysts, one with a clinical profile of local compression and the other one asymptomatic. The first case is a 75 year-old man who reported difficulty in defecating and urinating. An ultrasound revealed a large pelvic cystic mass displacing the bladder and rectosigmoid region. Computed tomography showed images compatible with hydatid disease and a hydatid liver cyst. The patient underwent a surgical procedure, with the pelvic cyst being partially excised. The other case of pelvic hydatid disease was asymptomatic, and was discovered by chance while examining a 75 year-old man for a prostatic adenoma. Because he was asymptomatic, we opted for observation. The pathology confirmed the diagnosis in the first case and radiological findings confirmed the second. Both patients are now asymptomatic. Hydatid disease must be considered in the differential diagnosis of any cystic masses in the pelvic organs, especially in countries where the disease is endemic. Although there are no serological tests which are 100% specific, there are some radiological procedures which can help to confirm the disease. Surgery is the treatment of choice.
Published: 2009

39. New case of an infrarenal abdominal aortic aneurysm associated with horseshoe kidney.

Author: Senarriaga Ruiz de la Illa N, Vega Manrique R, Lacasa Viscasillas I, Iriarte Soldevilla I, and Unda Urzaiz M
Subjects: Aged, 80 and over, Aortic Aneurysm, Abdominal diagnosis, Aortic Aneurysm, Abdominal surgery, Humans, Male, Aortic Aneurysm, Abdominal complications, Kidney abnormalities
Abstract: We review the association between surgically resolvable aortic disease and horseshoe kidney with a discussion of diagnostic problems and therapeutic options. Male patient 81 years of age with horseshoe kidney and an abdominal aortic aneurysm that was discovered by chance in an abdominal ultrasound during a check-up for his prostate condition. A retroperitoneal approach was used in order to resect the aneurysm and perform an aorto-aortic bypass with no complications occurring. Two years after the diagnosis, the patient is still asymptomatic from a vascular point of view. The co-presence of horseshoe kidney and aortic disease needing surgical correction is infrequent, but it significantly increases the technical complexity of aortic reconstruction. A literature review is included.
Published: 2009

40. [Inflammatory aortic aneurysm and its relationship to urological disease: a case report and a literature review].

Author: Senarriaga Ruiz de la Illa N, Vega Manrique R, Lacasa Viscasillas I, Arciniega García JM, and Unda Urzaiz M
Subjects: Aortic Aneurysm, Abdominal diagnosis, Aortic Aneurysm, Abdominal surgery, Aortitis diagnosis, Aortitis surgery, Humans, Male, Middle Aged, Aortic Aneurysm, Abdominal complications, Aortitis complications
Abstract: Objective: To report a successfully treated case of inflammatory aortic aneurysm., Materials and Methods: A 57-year-old patient reported low back pain and urinary infections. An abdominal CT scan revealed a large inflammatory aneurysm in the abdominal aorta. An aortic bypass was performed with no complications., Results: Patient course since surgery has been uneventful, and currently has no symptoms., Conclusions: Contribution of the radiographic team, mainly with the CT scan, is of great value both for differential diagnosis and adequate management and follow-up. Surgery is indicated to prevent aneurysm rupture, but an increased postoperative morbidity and mortality should be assumed., (Copyright 2008 AEU. Published by Elsevier España, S.L. All rights reserved.)
Published: 2009
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41. [Does a pT0 cystectomy specimen imply being tumour-free in the long term?].

Author: Loizaga Iriarte A, Senarriaga Ruiz de la Illa N, Lacasa Viscasillas I, Rábade Ferreiro A, Iriarte Soldevilla I, and Unda Urzaiz M
Subjects: Adult, Aged, Disease-Free Survival, Female, Humans, Male, Middle Aged, Neoplasm Staging, Prognosis, Time Factors, Cystectomy, Urinary Bladder Neoplasms pathology, Urinary Bladder Neoplasms surgery
Abstract: Introduction and Objectives: The aim of this study was to evaluate the progress of patients with a pT0 radical cystectomy specimen in order to know what factors are helpful in deciding when the bladder can be preserved., Material and Methods: We reviewed 153 cases of radical cystectomies performed due to bladder tumours without neoadjuvant therapy between 1995 and 2005 and with a minimum of three years of follow-up. Stage pT0 patients were selected. We considered age at time of diagnosis, sex, pathological stage and grade of the tumour at the time of transurethral resection (TUR), number of resections, surgical factors, tumour characteristics (multifocal, papillary or solid), progression-free survival, cancer-specific survival and cause of death. We ran a univariate analysis of the different factors studied along with disease progression., Results: 12.8% of cystectomy specimens were pT0N0. Progression occurred in 35% between 6 months and 4 years after the cystectomy. Cancer-specific survival was 75%. Five patients died within an average of 18 months. The cause of death for all of them was tumour progression with distant metastasis. Statistical studies in the univariate analysis were only related to progression and the number of prior TURs, which is probably due to the number of cases, but the tumour multifocality, grade and stage were noteworthy. 15% of the pT0 patients had a papillary phenotype and 33% of them died. Of those with a non-papillary phenotype, 23.5% died., Conclusions: A stage pT0N0 cystectomy specimen does not define this surgery as curative, and these cases require the same follow-up as for the rest of the patients. It is of particular interest that out of all of our cases, there was no local recurrence, but there was distant metastasis. This leads us to believe that these patients could have benefitted from systemic chemotherapy with no need for radical surgery. In our study, the number of previous relapses was the only prognostic factor with statistical significance.
Published: 2009
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42. [Current treatment of small renal masses].

Author: Iriarte Soldevilla JI, Senarriaga Ruiz de la Illa N, Lacasa Viscasillas I, Loizaga Iriarte A, Zubiaur Libano C, and Unda Urzaiz M
Subjects: Aged, Aged, 80 and over, Catheter Ablation, Cryotherapy, Female, Humans, Kidney Neoplasms pathology, Male, Middle Aged, Kidney Neoplasms therapy
Abstract: Unlabelled: Incidental diagnosis of renal carcinoma (RC) is increasingly common due to widespread use of radiodiagnostic techniques for other conditions. In developed countries, incidental tumor account for more than 40% of detected tumors, and 80% of solid kidney tumors less than 4 cm in size are malignant. Standard treatment for these tumors is partial nephrectomy, and their relapse rate is 1%-2% The higher increase in diagnosis of this disease has occurred in patients aged 70 to 90 years, a group where associated comorbidities are very common. In the past two decades, in parallel to development of radiographic techniques, two ablation procedures achieving tumor necrosis through cold, cryotherapy, and through heat, radiofrequency, have become established. These procedures achieve 95% short- and long-term remissions in tumors less than 4 cm in size. In addition, since these procedures may be performed percutaneously, both complications and hospital stay have decreased. As early as in 1995, Bosniak, based on observation of the growth and behavior of small RCs for longer than 8 years, advocated a watchful waiting or active surveillance attitude. This article reports cryotherapy, our radiofrequency series, and a literature review., Conclusions: In the event of elderly patients, concomitant diseases advising against surgery, multiple renal tumors, a solitary kidney, or patients who reject surgery, ablation procedures may be safe and effective when performed by expert hands, achieving mid-term oncological results similar to partial nephrectomy. Active surveillance has also been shown to be safe in the mid-term in adequately informed patients. To improve indications, new diagnostic procedures that help us differentiate the potentially more aggressive tumors will be required. Larger series and longer follow-ups are neede to confirm current results.
Published: 2009
Full Text: View/download PDF

43. [Prostatic utricle ductal carcinoma. Case report and bibliographic review].

Author: Senarriaga Ruiz de la Illa N, Loizaga Iriarte A, Larrinaga Izaguirre JR, Lacasa Viscasillas I, Arciniega García JM, and Unda Urzaiz M
Subjects: Aged, Humans, Male, Carcinoma, Ductal diagnosis, Prostatic Neoplasms diagnosis
Abstract: Objective: A case of ductal carcinoma of the prostatic utricle is described, previously known as endometrial carcinoma, and literature is reviewed., Methods: 75-years-old patient who consults for lower urinary tract obstructive symptoms, with a PSA of 8.1 ng/ml., without more symptoms. Digital rectal examination and ultrasound showed a small and stony prostate. Deobstructive transurethral resection of the prostate was performed and the biopsy revealed ductal carcinoma of the utricle., Results: Nine years after diagnosis signs of dissemination are not present., Conclusions: As incidental finding in the biopsy, ductal carcinoma of the utricle is a rare tumor, the incidence of which among all prostatic carcinomas has been cited as 0.2-0.8%. We report a review about this topic for improving its knowledge. Symptoms, pathological findings and treatment of this carcinoma have been reviewed.
Published: 2008
Full Text: View/download PDF

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