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Your search keyword '"Lacava, Nicola"' showing total 16 results
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16 results on '"Lacava, Nicola"'

13. Elective intensive care after lung resection: a multicentric propensity-matched comparison of outcome.

Author

Brunelli, Alessandro, Pieretti, Paola, Al Refai, Majed, Lacava, Nicola, Xiume', Francesco, Boaron, Maurizio, Zanello, Marco, and Sabbatini, Armando

Abstract

The study was aimed at assessing the influence of the elective ICU admission on the early outcome after major lung resection by analyzing the different postoperative management policies of two centers. Center A managed all patients in a dedicated ward, resorting to ICU for complications requiring invasive assisted ventilation. In center B, high-risk patients were electively transferred to ICU immediately after operation. Propensity score was used to match those patients of center B electively admitted to ICU (96 of 157), with counterparts from center A (96 of 205). The outcome of these matched pairs were then compared. There was a trend of reduced total morbidity (23% vs. 35%, respectively; P=0.06), cardiovascular (13.5% vs. 23%, respectively; P=0.09) and pulmonary complication rates (9.3% vs. 18%, respectively; P=0.09), but a longer postoperative hospital stay (11.5 vs. 9.7, respectively; P=0.015) in the patients electively admitted to ICU, compared to matched center A patients. Mortality rates were not different (7.3% vs. 7.3%; P=1). Since the elective postoperative ICU admission did not show a clear-cut outcome benefit over the management in a dedicated ward, this practice should be limited to highly selected patients in order to efficiently utilize the available resources.

Published
2005
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15. Endobronchial Pagetoid Spread of a Breast Carcinoma Metastatic to the Lung

Author

Paola Baccarini, Maria C. Cucchi, Nicola Lacava, Maria Pia Foschini, Melissa A. T. Monica, Monica, Melissa A. T., Baccarini, Paola, Cucchi, Maria C., Lacava, Nicola, and Foschini, Maria P.

Subjects
Pathology, medicine.medical_specialty, HER-2 amplification, Bronchi, Pathology and Forensic Medicine, 030207 dermatology & venereal diseases, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, Biomarkers, Tumor, Medicine, Lobar Bronchus, Aged, Neoplasm Invasivene, Lung, endobronchial pagetoid spread, business.industry, Carcinoma, Ductal, Breast, Histology, respiratory system, medicine.disease, Immunohistochemistry, Primary tumor, Metastatic breast cancer, Lung Neoplasm, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Pagetoid, Female, Surgery, metastatic breast cancer, Anatomy, business, Breast carcinoma, Breast Neoplasm, Human
Abstract

A case of endobronchial pagetoid spread of a breast carcinoma metastatic to the lung is described. A 73-year-old woman underwent wedge lung resection after the cytological diagnosis of lung metastasis from ductal invasive breast carcinoma. The breast carcinoma had been surgically removed 6 years previously; at the time of diagnosis it was a T1N0, grade 3 invasive ductal carcinoma, with HER-2 amplification. The lung metastasis measured 1,9 cm and showed the same histology and biological profile of the primary tumor. In addition, numerous neoplastic cells, with large cytoplasm and atypical nuclei, appear to spread along the mucosa of the bronchi adjacent to the metastatic lesion as well as that of the main lobar bronchus, intermingled with the columnar ciliated cells. The neoplastic elements were negative for TTF-1 and strongly HER-2 positive; these features appeared consistent with endobronchial pagetoid spread by the metastatic breast carcinomatous cells.

Published
2016
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