Search

Your search keyword '"Lacerda, Marcus V. G."' showing total 470 results
Start Over Author "Lacerda, Marcus V. G."
470 results on '"Lacerda, Marcus V. G."'

1. Assessing tafenoquine implementation in Brazil: a qualitative evaluation of perceptions of healthcare providers and Plasmodium vivax patients (QualiTRuST Study)

Author

Santos, Alicia P. C., Brito, Marcelo A. M., Oliveira, Ana P. S., Dávila, Rafaela N., Gama, Hiran S. S., Silva, Evellyn A. R. T., Amazonas Jr., Hélio A., Balieiro, Patrícia C. S., Rufatto, Rosilene, Grewal Daumerie, Penny, Peterka, Cássio R. L., Batista Pereira, Dhélio, Lacerda, Marcus V. G., and Murta, Felipe L. G.

Published
2024
Full Text
View/download PDF

2. Host metabolomic responses in recurrent P. vivax malaria

Author

Yakubu, Michael N., Mwangi, Victor I., Netto, Rebeca L. A., Alecrim, Maria G. C., Alves, Jessica R. S., Almeida, Anne C. G., Santos, Gabriel F., Lima, Gesiane S., Machado, Lucas S., Koolen, Hector H. F., Guimarães, Tiago P., Chaves, Andrea R., Vaz, Boniek G., Monteiro, Wuelton M., Costa, Fabio T. M., Lacerda, Marcus V. G., Gardinassi, Luiz G., and de Melo, Gisely C.

Published
2024
Full Text
View/download PDF

3. Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Author

Axfors, Cathrine, Schmitt, Andreas M., Janiaud, Perrine, van’t Hooft, Janneke, Abd-Elsalam, Sherief, Abdo, Ehab F., Abella, Benjamin S., Akram, Javed, Amaravadi, Ravi K., Angus, Derek C., Arabi, Yaseen M., Azhar, Shehnoor, Baden, Lindsey R., Baker, Arthur W., Belkhir, Leila, Benfield, Thomas, Berrevoets, Marvin A. H., Chen, Cheng-Pin, Chen, Tsung-Chia, Cheng, Shu-Hsing, Cheng, Chien-Yu, Chung, Wei-Sheng, Cohen, Yehuda Z., Cowan, Lisa N., Dalgard, Olav, de Almeida e Val, Fernando F., de Lacerda, Marcus V. G., de Melo, Gisely C., Derde, Lennie, Dubee, Vincent, Elfakir, Anissa, Gordon, Anthony C., Hernandez-Cardenas, Carmen M., Hills, Thomas, Hoepelman, Andy I. M., Huang, Yi-Wen, Igau, Bruno, Jin, Ronghua, Jurado-Camacho, Felipe, Khan, Khalid S., Kremsner, Peter G., Kreuels, Benno, Kuo, Cheng-Yu, Le, Thuy, Lin, Yi-Chun, Lin, Wu-Pu, Lin, Tse-Hung, Lyngbakken, Magnus Nakrem, McArthur, Colin, McVerry, Bryan J., Meza-Meneses, Patricia, Monteiro, Wuelton M., Morpeth, Susan C., Mourad, Ahmad, Mulligan, Mark J., Murthy, Srinivas, Naggie, Susanna, Narayanasamy, Shanti, Nichol, Alistair, Novack, Lewis A., O’Brien, Sean M., Okeke, Nwora Lance, Perez, Léna, Perez-Padilla, Rogelio, Perrin, Laurent, Remigio-Luna, Arantxa, Rivera-Martinez, Norma E., Rockhold, Frank W., Rodriguez-Llamazares, Sebastian, Rolfe, Robert, Rosa, Rossana, Røsjø, Helge, Sampaio, Vanderson S., Seto, Todd B., Shahzad, Muhammad, Soliman, Shaimaa, Stout, Jason E., Thirion-Romero, Ireri, Troxel, Andrea B., Tseng, Ting-Yu, Turner, Nicholas A., Ulrich, Robert J., Walsh, Stephen R., Webb, Steve A., Weehuizen, Jesper M., Velinova, Maria, Wong, Hon-Lai, Wrenn, Rebekah, Zampieri, Fernando G., Zhong, Wu, Moher, David, Goodman, Steven N., Ioannidis, John P. A., and Hemkens, Lars G.

Published
2024
Full Text
View/download PDF

5. Primaquine for uncomplicated Plasmodium vivax malaria in children younger than 15 years: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Alam, Mohammad Shafiul, Anstey, Nicholas M, Assefa, Ashenafi, Baird, J Kevin, Boyd, Sarah C, Chau, Nguyen H, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Erhart, Annette, Ferreira, Marcelo U, Ghimire, Prakash, Khan, Wasif A, Ley, Benedikt, Mekuria, Asrat H, Mueller, Ivo, Naadim, Mohammad N, Nosten, Francois, Price, David J, Pukrittayakamee, Sasithon, Rowland, Mark, Sattabongkot, Jetsumon, SuarezKurtz, Guilherme, Sutanto, Inge, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Commons, Robert J, Rajasekhar, Megha, Allen, Elizabeth N, Yilma, Daniel, Chotsiri, Palang, Abreha, Tesfay, Adam, Ishag, Awab, Ghulam Rahim, Barber, Bridget E, Brasil, Larissa W, Chu, Cindy S, Cui, Liwang, Edler, Peta, Gomes, Margarete do Socorro M, Gonzalez‑Ceron, Lilia, Grigg, Matthew J, Hamid, Muzamil Mahdi Abdel, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Leslie, Toby, Longley, Rhea J, Monteiro, Wuelton Marcelo, Pasaribu, Ayodhia Pitaloka, Poespoprodjo, Jeanne Rini, Richmond, Caitlin L, Rijal, Komal Raj, Taylor, Walter R J, Thanh, Pham Vinh, Thriemer, Kamala, Vieira, José Luiz F, White, Nicholas J, Zuluaga-Idarraga, Lina M, Workman, Lesley J, Tarning, Joel, Stepniewska, Kasia, Guerin, Philippe J, Simpson, Julie A, Barnes, Karen I, and Price, Ric N

Published
2024
Full Text
View/download PDF

6. Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in The Guianas: a descriptive epidemiological study

Author

Florimond, Celia, de Laval, Franck, Early, Angela M, Sauthier, Swaélie, Lazrek, Yassamine, Pelleau, Stéphane, Monteiro, Wuelton M, Agranier, Maxime, Taudon, Nicolas, Morin, François, Magris, Magda, Lacerda, Marcus V G, Viana, Giselle M R, Herrera, Sócrates, Adhin, Malti R, Ferreira, Marcelo U, Woodrow, Charles J, Awab, Ghulam R, Cox, Horace, Ade, Maria-Paz, Mosnier, Emilie, Djossou, Félix, Neafsey, Daniel E, Ringwald, Pascal, and Musset, Lise

Published
2024
Full Text
View/download PDF

7. Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Alam, Mohammad Shafiul, Anstey, Nicholas M, Assefa, Ashenafi, Boyd, Sarah C, Chau, Nguyen Hoang, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Ferreira, Marcelo Urbano, Ghimire, Prakash, Green, Justin A, Khan, Wasif Ali, Koh, Gavin CKW, Mekuria, Asrat Hailu, Naadim, Mohammad Nader, Nelwan, Erni J, Nosten, Francois, Pasaribu, Ayodhia Pitaloka, Price, David J, Stepniewska, Kasia, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Rajasekhar, Megha, Simpson, Julie A, Ley, Benedikt, Edler, Peta, Chu, Cindy S, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Bancone, Germana, Barber, Bridget E, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Llanos-Cuentas, Alejandro, Pukrittayakamee, Sasithon, Rijal, Komal R, Saravu, Kavitha, Sutanto, Inge, Taylor, Walter R J, Thriemer, Kamala, Watson, James A, Guerin, Philippe J, White, Nicholas J, Price, Ric N, and Commons, Robert J

Published
2024
Full Text
View/download PDF

8. Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Anstey, Nicholas M, Assefa, Ashenafi, Boyd, Sarah C, Chau, Nguyen Hoang, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Erhart, Annette, Ferreira, Marcelo Urbano, Ghimire, Prakash, Green, Justin A, Koh, Gavin CKW, Mekuria, Asrat Hailu, Mueller, Ivo, Naadim, Mohammad Nader, Nelwan, Erni J, Nosten, Francois, Price, David J, Sattabongkot, Jetsumon, Stepniewska, Kasia, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Commons, Robert J, Rajasekhar, Megha, Edler, Peta, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Chu, Cindy S, Cui, Liwang, Daher, André, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Lidia, Kartini, Llanos-Cuentas, Alejandro, Longley, Rhea J, Pereira, Dhelio B, Pasaribu, Ayodhia P, Pukrittayakamee, Sasithon, Rijal, Komal R, Sutanto, Inge, Taylor, Walter R J, Thanh, Pham V, Thriemer, Kamala, Vieira, José Luiz F, Watson, James A, Zuluaga-Idarraga, Lina M, White, Nicholas J, Guerin, Philippe J, Simpson, Julie A, and Price, Ric N

Published
2024
Full Text
View/download PDF

9. Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Author

Mehdipour, Parinaz, Rajasekhar, Megha, Dini, Saber, Zaloumis, Sophie, Abreha, Tesfay, Adam, Ishag, Awab, Ghulam Rahim, Baird, J. Kevin, Brasil, Larissa W., Chu, Cindy S., Cui, Liwang, Daher, André, do Socorro M Gomes, Margarete, Gonzalez‑Ceron, Lilia, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V. G., Ladeia-Andrade, Simone, Leslie, Toby, Ley, Benedikt, Lidia, Kartini, Llanos-Cuentas, Alejandro, Longley, Rhea J., Monteiro, Wuelton Marcelo, Pereira, Dhelio B., Rijal, Komal Raj, Saravu, Kavitha, Sutanto, Inge, Taylor, Walter R. J., Thanh, Pham Vinh, Thriemer, Kamala, Vieira, José Luiz F., White, Nicholas J., Zuluaga-Idarraga, Lina M., Guerin, Philippe J., Price, Ric N., Simpson, Julie A., and Commons, Robert J.

Published
2023
Full Text
View/download PDF

10. Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model

Author

Price, David J., Nekkab, Narimane, Monteiro, Wuelton M., Villela, Daniel A. M., Simpson, Julie A., Lacerda, Marcus V. G., White, Michael T., and Devine, Angela

Subjects
World Health Organization, EPUB (Standard) -- Comparative analysis, Economic aspects, Comparative analysis, Cost benefit analysis, Mortality -- Brazil, Cost benefit analysis -- Comparative analysis -- Economic aspects, Phosphates -- Economic aspects -- Comparative analysis, Tafenoquine -- Economic aspects -- Comparative analysis, Primaquine -- Economic aspects -- Comparative analysis, Patient compliance -- Comparative analysis -- Economic aspects, Medical research -- Comparative analysis -- Economic aspects, Malaria -- Economic aspects -- Comparative analysis, Medicine, Experimental -- Comparative analysis -- Economic aspects
Abstract

Author(s): David J. Price 1,2, Narimane Nekkab 3,4, Wuelton M. Monteiro 5,6, Daniel A. M. Villela 7, Julie A. Simpson 2, Marcus V. G. Lacerda 5,8, Michael T. White 9, [...], Background Malaria transmission modelling has demonstrated the potential impact of semiquantitative glucose-6-phosphate dehydrogenase (G6PD) testing and treatment with single-dose tafenoquine for Plasmodium vivax radical cure but has not investigated the associated costs. This study evaluated the cost-effectiveness of P. vivax treatment with tafenoquine after G6PD testing using a transmission model. Methods and findings We explored the cost-effectiveness of using tafenoquine after G6PD screening as compared to usual practice (7-day low-dose primaquine (0.5 mg/kg/day) without G6PD screening) in Brazil using a 10-year time horizon with 5% discounting considering 4 scenarios: (1) tafenoquine for adults only assuming 66.7% primaquine treatment adherence; (2) tafenoquine for adults and children aged >2 years assuming 66.7% primaquine adherence; (3) tafenoquine for adults only assuming 90% primaquine adherence; and (4) tafenoquine for adults only assuming 30% primaquine adherence. The incremental cost-effectiveness ratios (ICERs) were estimated by dividing the incremental costs by the disability-adjusted life years (DALYs) averted. These were compared to a willingness to pay (WTP) threshold of US$7,800 for Brazil, and one-way and probabilistic sensitivity analyses were performed. All 4 scenarios were cost-effective in the base case analysis using this WTP threshold with ICERs ranging from US$154 to US$1,836. One-way sensitivity analyses showed that the results were most sensitive to severity and mortality due to vivax malaria, the lifetime and number of semiquantitative G6PD analysers needed, cost per malaria episode and per G6PD test strips, and life expectancy. All scenarios had a 100% likelihood of being cost-effective at the WTP threshold. The main limitations of this study are due to parameter uncertainty around our cost estimates for low transmission settings, the costs of G6PD screening, and the severity of vivax malaria Conclusions In our modelling study that incorporated impact on transmission, tafenoquine prescribed after a semiquantitative G6PD testing was highly likely to be cost-effective in Brazil. These results demonstrate the potential health and economic importance of ensuring safe and effective radical cure.

Published
2024
Full Text
View/download PDF

11. Applying Faster R-CNN for Object Detection on Malaria Images

Author

Hung, Jane, Ravel, Deepali, Lopes, Stefanie C. P., Rangel, Gabriel, Nery, Odailton Amaral, Malleret, Benoit, Nosten, Francois, Lacerda, Marcus V. G., Ferreira, Marcelo U., Rénia, Laurent, Duraisingh, Manoj T., Costa, Fabio T. M., Marti, Matthias, and Carpenter, Anne E.

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Deep learning based models have had great success in object detection, but the state of the art models have not yet been widely applied to biological image data. We apply for the first time an object detection model previously used on natural images to identify cells and recognize their stages in brightfield microscopy images of malaria-infected blood. Many micro-organisms like malaria parasites are still studied by expert manual inspection and hand counting. This type of object detection task is challenging due to factors like variations in cell shape, density, and color, and uncertainty of some cell classes. In addition, annotated data useful for training is scarce, and the class distribution is inherently highly imbalanced due to the dominance of uninfected red blood cells. We use Faster Region-based Convolutional Neural Network (Faster R-CNN), one of the top performing object detection models in recent years, pre-trained on ImageNet but fine tuned with our data, and compare it to a baseline, which is based on a traditional approach consisting of cell segmentation, extraction of several single-cell features, and classification using random forests. To conduct our initial study, we collect and label a dataset of 1300 fields of view consisting of around 100,000 individual cells. We demonstrate that Faster R-CNN outperforms our baseline and put the results in context of human performance., Comment: CVPR 2017: computer vision for microscopy image analysis (CVMI) Workshop

Published
2018

13. Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination?

Author

Chaves, Bárbara Aparecida, de Alvarenga, Denise Anete Madureira, Pereira, Matheus de Oliveira Costa, Gordo, Marcelo, Da Silva, Emanuelle L., Costa, Edson Rodrigues, Medeiros, Aline Souza de Menezes, Pedrosa, Igor José Martins, Brito, Daniela, Lima, Maurício Teixeira, Mourão, Maria Paula, Monteiro, Wuelton M., Vasilakis, Nikos, de Brito, Cristiana Ferreira Alves, Melo, Gisely C., and Lacerda, Marcus V. G.

Published
2022
Full Text
View/download PDF

14. A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria

Author

Trimarsanto, Hidayat, Amato, Roberto, Pearson, Richard D., Sutanto, Edwin, Noviyanti, Rintis, Trianty, Leily, Marfurt, Jutta, Pava, Zuleima, Echeverry, Diego F., Lopera-Mesa, Tatiana M., Montenegro, Lidia M., Tobón-Castaño, Alberto, Grigg, Matthew J., Barber, Bridget, William, Timothy, Anstey, Nicholas M., Getachew, Sisay, Petros, Beyene, Aseffa, Abraham, Assefa, Ashenafi, Rahim, Awab G., Chau, Nguyen H., Hien, Tran T., Alam, Mohammad S., Khan, Wasif A., Ley, Benedikt, Thriemer, Kamala, Wangchuck, Sonam, Hamedi, Yaghoob, Adam, Ishag, Liu, Yaobao, Gao, Qi, Sriprawat, Kanlaya, Ferreira, Marcelo U., Laman, Moses, Barry, Alyssa, Mueller, Ivo, Lacerda, Marcus V. G., Llanos-Cuentas, Alejandro, Krudsood, Srivicha, Lon, Chanthap, Mohammed, Rezika, Yilma, Daniel, Pereira, Dhelio B., Espino, Fe E. J., Chu, Cindy S., Vélez, Iván D., Namaik-larp, Chayadol, Villegas, Maria F., Green, Justin A., Koh, Gavin, Rayner, Julian C., Drury, Eleanor, Gonçalves, Sónia, Simpson, Victoria, Miotto, Olivo, Miles, Alistair, White, Nicholas J., Nosten, Francois, Kwiatkowski, Dominic P., Price, Ric N., and Auburn, Sarah

Published
2022
Full Text
View/download PDF

16. Author Correction 2024: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials(Nature Communications, (2021), 12, (1), 10.1038/s41467-021-22446-z)

Author

Medische Staf Intensive Care, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, MS Interne Geneeskunde, MS Dermatologie/Allergologie, MS Infectieziekten, Axfors, Cathrine, Schmitt, Andreas M, Janiaud, Perrine, Van't Hooft, Janneke, Abd-Elsalam, Sherief, Abdo, Ehab F, Abella, Benjamin S, Akram, Javed, Amaravadi, Ravi K, Angus, Derek C, Arabi, Yaseen M, Azhar, Shehnoor, Baden, Lindsey R, Baker, Arthur W, Belkhir, Leila, Benfield, Thomas, Berrevoets, Marvin A H, Chen, Cheng-Pin, Chen, Tsung-Chia, Cheng, Shu-Hsing, Cheng, Chien-Yu, Chung, Wei-Sheng, Cohen, Yehuda Z, Cowan, Lisa N, Dalgard, Olav, de Almeida E Val, Fernando F, de Lacerda, Marcus V G, de Melo, Gisely C, Derde, Lennie, Dubee, Vincent, Elfakir, Anissa, Gordon, Anthony C, Hernandez-Cardenas, Carmen M, Hills, Thomas, Hoepelman, Andy I M, Huang, Yi-Wen, Igau, Bruno, Jin, Ronghua, Jurado-Camacho, Felipe, Khan, Khalid S, Kremsner, Peter G, Kreuels, Benno, Kuo, Cheng-Yu, Le, Thuy, Lin, Yi-Chun, Lin, Wu-Pu, Lin, Tse-Hung, Lyngbakken, Magnus Nakrem, McArthur, Colin, McVerry, Bryan J, Meza-Meneses, Patricia, Monteiro, Wuelton M, Morpeth, Susan C, Mourad, Ahmad, Mulligan, Mark J, Murthy, Srinivas, Naggie, Susanna, Narayanasamy, Shanti, Nichol, Alistair, Novack, Lewis A, O'Brien, Sean M, Okeke, Nwora Lance, Perez, Léna, Perez-Padilla, Rogelio, Perrin, Laurent, Remigio-Luna, Arantxa, Rivera-Martinez, Norma E, Rockhold, Frank W, Rodriguez-Llamazares, Sebastian, Rolfe, Robert, Rosa, Rossana, Røsjø, Helge, Sampaio, Vanderson S, Seto, Todd B, Shahzad, Muhammad, Soliman, Shaimaa, Stout, Jason E, Thirion-Romero, Ireri, Troxel, Andrea B, Tseng, Ting-Yu, Turner, Nicholas A, Ulrich, Robert J, Walsh, Stephen R, Webb, Steve A, Weehuizen, Jesper M, Velinova, Maria, Wong, Hon-Lai, Wrenn, Rebekah, Zampieri, Fernando G, Zhong, Wu, Moher, David, Goodman, Steven N, Ioannidis, John P A, Hemkens, Lars G, Medische Staf Intensive Care, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, MS Interne Geneeskunde, MS Dermatologie/Allergologie, MS Infectieziekten, Axfors, Cathrine, Schmitt, Andreas M, Janiaud, Perrine, Van't Hooft, Janneke, Abd-Elsalam, Sherief, Abdo, Ehab F, Abella, Benjamin S, Akram, Javed, Amaravadi, Ravi K, Angus, Derek C, Arabi, Yaseen M, Azhar, Shehnoor, Baden, Lindsey R, Baker, Arthur W, Belkhir, Leila, Benfield, Thomas, Berrevoets, Marvin A H, Chen, Cheng-Pin, Chen, Tsung-Chia, Cheng, Shu-Hsing, Cheng, Chien-Yu, Chung, Wei-Sheng, Cohen, Yehuda Z, Cowan, Lisa N, Dalgard, Olav, de Almeida E Val, Fernando F, de Lacerda, Marcus V G, de Melo, Gisely C, Derde, Lennie, Dubee, Vincent, Elfakir, Anissa, Gordon, Anthony C, Hernandez-Cardenas, Carmen M, Hills, Thomas, Hoepelman, Andy I M, Huang, Yi-Wen, Igau, Bruno, Jin, Ronghua, Jurado-Camacho, Felipe, Khan, Khalid S, Kremsner, Peter G, Kreuels, Benno, Kuo, Cheng-Yu, Le, Thuy, Lin, Yi-Chun, Lin, Wu-Pu, Lin, Tse-Hung, Lyngbakken, Magnus Nakrem, McArthur, Colin, McVerry, Bryan J, Meza-Meneses, Patricia, Monteiro, Wuelton M, Morpeth, Susan C, Mourad, Ahmad, Mulligan, Mark J, Murthy, Srinivas, Naggie, Susanna, Narayanasamy, Shanti, Nichol, Alistair, Novack, Lewis A, O'Brien, Sean M, Okeke, Nwora Lance, Perez, Léna, Perez-Padilla, Rogelio, Perrin, Laurent, Remigio-Luna, Arantxa, Rivera-Martinez, Norma E, Rockhold, Frank W, Rodriguez-Llamazares, Sebastian, Rolfe, Robert, Rosa, Rossana, Røsjø, Helge, Sampaio, Vanderson S, Seto, Todd B, Shahzad, Muhammad, Soliman, Shaimaa, Stout, Jason E, Thirion-Romero, Ireri, Troxel, Andrea B, Tseng, Ting-Yu, Turner, Nicholas A, Ulrich, Robert J, Walsh, Stephen R, Webb, Steve A, Weehuizen, Jesper M, Velinova, Maria, Wong, Hon-Lai, Wrenn, Rebekah, Zampieri, Fernando G, Zhong, Wu, Moher, David, Goodman, Steven N, Ioannidis, John P A, and Hemkens, Lars G

Published
2024

17. Primaquine for uncomplicated Plasmodium vivaxmalaria in children younger than 15 years: a systematic review and individual patient data meta-analysis

Author

Commons, Robert J, Rajasekhar, Megha, Allen, Elizabeth N, Yilma, Daniel, Chotsiri, Palang, Abreha, Tesfay, Adam, Ishag, Awab, Ghulam Rahim, Barber, Bridget E, Brasil, Larissa W, Chu, Cindy S, Cui, Liwang, Edler, Peta, Gomes, Margarete do Socorro M, Gonzalez‑Ceron, Lilia, Grigg, Matthew J, Hamid, Muzamil Mahdi Abdel, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Leslie, Toby, Longley, Rhea J, Monteiro, Wuelton Marcelo, Pasaribu, Ayodhia Pitaloka, Poespoprodjo, Jeanne Rini, Richmond, Caitlin L, Rijal, Komal Raj, Taylor, Walter R J, Thanh, Pham Vinh, Thriemer, Kamala, Vieira, José Luiz F, White, Nicholas J, Zuluaga-Idarraga, Lina M, Workman, Lesley J, Tarning, Joel, Stepniewska, Kasia, Guerin, Philippe J, Simpson, Julie A, Barnes, Karen I, Price, Ric N, Adhikari, Bipin, Alam, Mohammad Shafiul, Anstey, Nicholas M, Assefa, Ashenafi, Baird, J Kevin, Boyd, Sarah C, Chau, Nguyen H, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Erhart, Annette, Ferreira, Marcelo U, Ghimire, Prakash, Khan, Wasif A, Ley, Benedikt, Mekuria, Asrat H, Mueller, Ivo, Naadim, Mohammad N, Nosten, Francois, Price, David J, Pukrittayakamee, Sasithon, Rowland, Mark, Sattabongkot, Jetsumon, SuarezKurtz, Guilherme, Sutanto, Inge, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, and Woyessa, Adugna

Abstract

Primaquine, the only widely available treatment to prevent relapsing Plasmodium vivaxmalaria, is produced as 15 mg tablets, and new paediatric formulations are being developed. To inform the optimal primaquine dosing regimen for children, we aimed to determine the efficacy and safety of different primaquine dose strategies in children younger than 15 years.

Published
2024
Full Text
View/download PDF

18. Author Correction: Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Author

Axfors, Cathrine, Schmitt, Andreas M., Janiaud, Perrine, van’t Hooft, Janneke, Abd-Elsalam, Sherief, Abdo, Ehab F., Abella, Benjamin S., Akram, Javed, Amaravadi, Ravi K., Angus, Derek C., Arabi, Yaseen M., Azhar, Shehnoor, Baden, Lindsey R., Baker, Arthur W., Belkhir, Leila, Benfield, Thomas, Berrevoets, Marvin A. H., Chen, Cheng-Pin, Chen, Tsung-Chia, Cheng, Shu-Hsing, Cheng, Chien-Yu, Chung, Wei-Sheng, Cohen, Yehuda Z., Cowan, Lisa N., Dalgard, Olav, de Almeida e Val, Fernando F., de Lacerda, Marcus V. G., de Melo, Gisely C., Derde, Lennie, Dubee, Vincent, Elfakir, Anissa, Gordon, Anthony C., Hernandez-Cardenas, Carmen M., Hills, Thomas, Hoepelman, Andy I. M., Huang, Yi-Wen, Igau, Bruno, Jin, Ronghua, Jurado-Camacho, Felipe, Khan, Khalid S., Kremsner, Peter G., Kreuels, Benno, Kuo, Cheng-Yu, Le, Thuy, Lin, Yi-Chun, Lin, Wu-Pu, Lin, Tse-Hung, Lyngbakken, Magnus Nakrem, McArthur, Colin, McVerry, Bryan J., Meza-Meneses, Patricia, Monteiro, Wuelton M., Morpeth, Susan C., Mourad, Ahmad, Mulligan, Mark J., Murthy, Srinivas, Naggie, Susanna, Narayanasamy, Shanti, Nichol, Alistair, Novack, Lewis A., O’Brien, Sean M., Okeke, Nwora Lance, Perez, Léna, Perez-Padilla, Rogelio, Perrin, Laurent, Remigio-Luna, Arantxa, Rivera-Martinez, Norma E., Rockhold, Frank W., Rodriguez-Llamazares, Sebastian, Rolfe, Robert, Rosa, Rossana, Røsjø, Helge, Sampaio, Vanderson S., Seto, Todd B., Shahzad, Muhammad, Soliman, Shaimaa, Stout, Jason E., Thirion-Romero, Ireri, Troxel, Andrea B., Tseng, Ting-Yu, Turner, Nicholas A., Ulrich, Robert J., Walsh, Stephen R., Webb, Steve A., Weehuizen, Jesper M., Velinova, Maria, Wong, Hon-Lai, Wrenn, Rebekah, Zampieri, Fernando G., Zhong, Wu, Moher, David, Goodman, Steven N., Ioannidis, John P. A., and Hemkens, Lars G.

Published
2021
Full Text
View/download PDF

21. Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

Author

Axfors, Cathrine, Schmitt, Andreas M., Janiaud, Perrine, van’t Hooft, Janneke, Abd-Elsalam, Sherief, Abdo, Ehab F., Abella, Benjamin S., Akram, Javed, Amaravadi, Ravi K., Angus, Derek C., Arabi, Yaseen M., Azhar, Shehnoor, Baden, Lindsey R., Baker, Arthur W., Belkhir, Leila, Benfield, Thomas, Berrevoets, Marvin A. H., Chen, Cheng-Pin, Chen, Tsung-Chia, Cheng, Shu-Hsing, Cheng, Chien-Yu, Chung, Wei-Sheng, Cohen, Yehuda Z., Cowan, Lisa N., Dalgard, Olav, de Almeida e Val, Fernando F., de Lacerda, Marcus V. G., de Melo, Gisely C., Derde, Lennie, Dubee, Vincent, Elfakir, Anissa, Gordon, Anthony C., Hernandez-Cardenas, Carmen M., Hills, Thomas, Hoepelman, Andy I. M., Huang, Yi-Wen, Igau, Bruno, Jin, Ronghua, Jurado-Camacho, Felipe, Khan, Khalid S., Kremsner, Peter G., Kreuels, Benno, Kuo, Cheng-Yu, Le, Thuy, Lin, Yi-Chun, Lin, Wu-Pu, Lin, Tse-Hung, Lyngbakken, Magnus Nakrem, McArthur, Colin, McVerry, Bryan J., Meza-Meneses, Patricia, Monteiro, Wuelton M., Morpeth, Susan C., Mourad, Ahmad, Mulligan, Mark J., Murthy, Srinivas, Naggie, Susanna, Narayanasamy, Shanti, Nichol, Alistair, Novack, Lewis A., O’Brien, Sean M., Okeke, Nwora Lance, Perez, Léna, Perez-Padilla, Rogelio, Perrin, Laurent, Remigio-Luna, Arantxa, Rivera-Martinez, Norma E., Rockhold, Frank W., Rodriguez-Llamazares, Sebastian, Rolfe, Robert, Rosa, Rossana, Røsjø, Helge, Sampaio, Vanderson S., Seto, Todd B., Shahzad, Muhammad, Soliman, Shaimaa, Stout, Jason E., Thirion-Romero, Ireri, Troxel, Andrea B., Tseng, Ting-Yu, Turner, Nicholas A., Ulrich, Robert J., Walsh, Stephen R., Webb, Steve A., Weehuizen, Jesper M., Velinova, Maria, Wong, Hon-Lai, Wrenn, Rebekah, Zampieri, Fernando G., Zhong, Wu, Moher, David, Goodman, Steven N., Ioannidis, John P. A., and Hemkens, Lars G.

Published
2021
Full Text
View/download PDF

22. The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis

Author

Commons, Robert J, Simpson, Julie A, Thriemer, Kamala, Humphreys, Georgina S, Abreha, Tesfay, Alemu, Sisay G, Añez, Arletta, Anstey, Nicholas M, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Borghini-Fuhrer, Isabelle, Chu, Cindy S, D'Alessandro, Umberto, Dahal, Prabin, Daher, André, de Vries, Peter J, Erhart, Annette, Gomes, Margarete S M, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Heidari, Aliehsan, Hwang, Jimee, Kager, Piet A, Ketema, Tsige, Khan, Wasif A, Lacerda, Marcus V G, Leslie, Toby, Ley, Benedikt, Lidia, Kartini, Monteiro, Wuelton M, Nosten, Francois, Pereira, Dhelio B, Phan, Giao T, Phyo, Aung P, Rowland, Mark, Saravu, Kavitha, Sibley, Carol H, Siqueira, André M, Stepniewska, Kasia, Sutanto, Inge, Taylor, Walter R J, Thwaites, Guy, Tran, Binh Q, Tran, Hien T, Valecha, Neena, Vieira, José Luiz F, Wangchuk, Sonam, William, Timothy, Woodrow, Charles J, Zuluaga-Idarraga, Lina, Guerin, Philippe J, White, Nicholas J, and Price, Ric N

Published
2018
Full Text
View/download PDF

23. Methylprednisolone therapy induces differential metabolic trajectories in severe COVID-19 patients

Author

Mwangi, Victor I., primary, Netto, Rebeca L. A., additional, Borba, Mayla G. S., additional, Santos, Gabriel F., additional, Lima, Gesiane S., additional, Machado, Lucas S., additional, Yakubu, Michael N., additional, Val, Fernando F. A., additional, Sampaio, Vanderson S., additional, Sartim, Marco A., additional, Koolen, Hector H. F., additional, Costa, Allyson G., additional, Toméi, Maria C. M., additional, Guimarães, Tiago P., additional, Chaves, Andrea R., additional, Vaz, Boniek G., additional, Lacerda, Marcus V. G., additional, Monteiro, Wuelton M., additional, Gardinassi, Luiz G., additional, and Melo, Gisely C., additional

Published
2023
Full Text
View/download PDF

25. Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis

Author

Adissu, Wondimagegn, primary, Brito, Marcelo, additional, Garbin, Eduardo, additional, Macedo, Marcela, additional, Monteiro, Wuelton, additional, Mukherjee, Sandip Kumar, additional, Myburg, Jane, additional, Alam, Mohammad Shafiul, additional, Bancone, Germana, additional, Bansil, Pooja, additional, Pal, Sampa, additional, Sharma, Abhijit, additional, Zobrist, Stephanie, additional, Bryan, Andrew, additional, Chu, Cindy S., additional, Das, Santasabuj, additional, Domingo, Gonzalo J., additional, Hann, Amanda, additional, Kublin, James, additional, Lacerda, Marcus V. G., additional, Layton, Mark, additional, Ley, Benedikt, additional, Murphy, Sean C., additional, Nosten, Francois, additional, Pereira, Dhélio, additional, Price, Ric N., additional, Talukdar, Arunansu, additional, Yilma, Daniel, additional, and Gerth-Guyette, Emily, additional

Published
2023
Full Text
View/download PDF

26. Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in French Guiana: a descriptive epidemiological study

Author

Florimond, Celia, primary, de Laval, Franck, additional, Early, Angela M, additional, Sauthier, Swaélie, additional, Lazrek, Yassamine, additional, Pelleau, Stéphane, additional, Monteiro, Wuelton M, additional, Agranier, Maxime, additional, Taudon, Nicolas, additional, Morin, François, additional, Magris, Magda, additional, Lacerda, Marcus V G, additional, Viana, Giselle M R, additional, Herrera, Sócrates, additional, Adhin, Malti R, additional, Ferreira, Marcelo U, additional, Woodrow, Charles J, additional, Awab, Ghulam R, additional, Cox, Horace, additional, Ade, Maria-Paz, additional, Mosnier, Emilie, additional, Djossou, Félix, additional, Neafsey, Daniel E, additional, Ringwald, Pascal, additional, and Musset, Lise, additional

Published
2023
Full Text
View/download PDF

27. Rosettes integrity protects Plasmodium vivax of being phagocytized

Author

Albrecht, Letusa, Lopes, Stefanie C. P., da Silva, Ana Beatriz Iung Enembreck, Barbosa, Vanessa, Almeida, Rodrigo P., Siqueira, André M., Leite, Juliana Almeida, Bittencourt, Najara C., dos Santos, Hellen Geremias, Bourgard, Catarina, Garcia, Luiz Fernando Cardoso, Kayano, Ana Carolina A. V., Soares, Irene S., Russell, Bruce, Rénia, Laurent, Lacerda, Marcus V. G., and Costa, Fabio T. M.

Published
2020
Full Text
View/download PDF

30. Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Author

Toda, Haruka, Diaz-Varela, Miriam, Segui-Barber, Joan, Roobsoong, Wanlapa, Baro, Barbara, Garcia-Silva, Susana, Galiano, Alicia, Gualdrón-López, Melisa, Almeida, Anne C. G., Brito, Marcelo A. M., de Melo, Gisely Cardoso, Aparici-Herraiz, Iris, Castro-Cavadía, Carlos, Monteiro, Wuelton Marcelo, Borràs, Eva, Sabidó, Eduard, Almeida, Igor C., Chojnacki, Jakub, Martinez-Picado, Javier, Calvo, Maria, Armengol, Pilar, Carmona-Fonseca, Jaime, Yasnot, Maria Fernanda, Lauzurica, Ricardo, Marcilla, Antonio, Peinado, Hector, Galinski, Mary R., Lacerda, Marcus V. G., Sattabongkot, Jetsumon, Fernandez-Becerra, Carmen, and del Portillo, Hernando A.

Published
2020
Full Text
View/download PDF

31. Severe Hemolysis during Primaquine Radical Cure of Plasmodium vivax Malaria: Two Systematic Reviews and Individual Patient Data Descriptive Analyses

Author

Yilma, Daniel, primary, Groves, Emily S., additional, Brito-Sousa, Jose Diego, additional, Monteiro, Wuelton M., additional, Chu, Cindy, additional, Thriemer, Kamala, additional, Commons, Robert J., additional, Lacerda, Marcus V. G., additional, Price, Ric N., additional, and Douglas, Nicholas M., additional

Published
2023
Full Text
View/download PDF

32. Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination

Author

Messina, Nicole L., primary, Sperotto, Mariana G., additional, Puga, Marco A. M., additional, da Silva, Patricia V., additional, de Oliveira, Roberto D., additional, Moore, Cecilia L., additional, Pittet, Laure F., additional, Jamieson, Tenaya, additional, Dalcolmo, Margareth, additional, dos Santos, Glauce, additional, Jardim, Bruno, additional, Lacerda, Marcus V. G., additional, Curtis, Nigel, additional, and Croda, Julio, additional

Published
2023
Full Text
View/download PDF

33. Fixed-Dose Artesunate–Amodiaquine Combination vs Chloroquine for Treatment of Uncomplicated Blood Stage P. vivax Infection in the Brazilian Amazon: An Open-Label Randomized, Controlled Trial

Author

Siqueira, Andre M., Alencar, Aline C., Melo, Gisely C., Magalhaes, Belisa L., Machado, Kim, Filho, Aristóteles C. Alencar, Kuehn, Andrea, Marques, Marly M., Manso, Monica Costa, Felger, Ingrid, Vieira, José L. F., Lameyre, Valerie, Daniel-Ribeiro, Claudio T., and Lacerda, Marcus V. G.

Published
2017

35. Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine

Author

Daher, André, Aljayyoussi, Ghait, Pereira, Dhelio, Lacerda, Marcus V. G., Alexandre, Márcia A. A., Nascimento, Cristiana T., Alves, Júlio Castro, da Fonseca, Laís Bastos, da Silva, Diego Medeiros Dias, Pinto, Douglas Pereira, Rodrigues, Danielle Fonseca, Silvino, Ana Carolina Rios, de Sousa, Taís Nóbrega, de Brito, Cristiana Ferreira Alves, ter Kuile, Feiko O., and Lalloo, David G.

Published
2019
Full Text
View/download PDF

36. The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Author

Commons, Robert J., Simpson, Julie A., Thriemer, Kamala, Chu, Cindy S., Douglas, Nicholas M., Abreha, Tesfay, Alemu, Sisay G., Añez, Arletta, Anstey, Nicholas M., Aseffa, Abraham, Assefa, Ashenafi, Awab, Ghulam R., Baird, J. Kevin, Barber, Bridget E., Borghini-Fuhrer, Isabelle, D’Alessandro, Umberto, Dahal, Prabin, Daher, André, de Vries, Peter J., Erhart, Annette, Gomes, Margarete S. M., Grigg, Matthew J., Hwang, Jimee, Kager, Piet A., Ketema, Tsige, Khan, Wasif A., Lacerda, Marcus V. G., Leslie, Toby, Ley, Benedikt, Lidia, Kartini, Monteiro, Wuelton M., Pereira, Dhelio B., Phan, Giao T., Phyo, Aung P., Rowland, Mark, Saravu, Kavitha, Sibley, Carol H., Siqueira, André M., Stepniewska, Kasia, Taylor, Walter R. J., Thwaites, Guy, Tran, Binh Q., Hien, Tran T., Vieira, José Luiz F., Wangchuk, Sonam, Watson, James, William, Timothy, Woodrow, Charles J., Nosten, Francois, Guerin, Philippe J., White, Nicholas J., and Price, Ric N.

Published
2019
Full Text
View/download PDF

37. Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers

Author

Bill & Melinda Gates Foundation, Minderoo Foundation, Royal Children's Hospital Foundation, National Health and Medical Research Council (Australia), Swiss National Science Foundation, European Molecular Biology Laboratory, Medical Research Council (UK), Health Services Union New South Wales Branch, Peter Sowerby Foundation, SA Health, Insurance Advisernet Foundation, NAB Foundation, Calvert-Jones Foundation, Modara Pines Charitable Foundation, United Health Foundation, Epworth HealthCare, Victoria State Government, Pittet, Laure F., Messina, Nicole L., Orsini, Francesca, Moore, Cecilia L., Abruzzo, Veronica, Barry, Simone, Bonnici, Rhian, Bonten, Marc, Campbell, John, Croda, Julio, Dalcolmo, Margareth, Gardiner, Kaya, Gell, Grace, Germano, Susie, Gomes-Silva, Adriano, Goodall, Casey, Gwee, Amanda, Jamieson, Tenaya, Jardim, Bruno, Kollmann, Tobias R., Lacerda, Marcus V. G., Lee, Katherine J., Lucas, Michaela, Lynn, David J., Manning, Laurens, Marshall, Helen S., McDonald, Ellie, Munns, Craig F., Nicholson, Suellen, O’Connell, Abby, Oliveira, Roberto D. de, Perlen, Susan, Perrett, Kirsten P., Prat-Aymerich, Cristina, Richmond, Peter C., Rodríguez-Baño, Jesús, Santos, Glauce dos, Silva, Patricia V. da, Teo, Jia Wei, Villanueva, Paola, Warris, Adilia, Wood, Nicholas J., Davidson, Andrew, Curtis, Nigel, BRACE Trial Consortium Group, Bill & Melinda Gates Foundation, Minderoo Foundation, Royal Children's Hospital Foundation, National Health and Medical Research Council (Australia), Swiss National Science Foundation, European Molecular Biology Laboratory, Medical Research Council (UK), Health Services Union New South Wales Branch, Peter Sowerby Foundation, SA Health, Insurance Advisernet Foundation, NAB Foundation, Calvert-Jones Foundation, Modara Pines Charitable Foundation, United Health Foundation, Epworth HealthCare, Victoria State Government, Pittet, Laure F., Messina, Nicole L., Orsini, Francesca, Moore, Cecilia L., Abruzzo, Veronica, Barry, Simone, Bonnici, Rhian, Bonten, Marc, Campbell, John, Croda, Julio, Dalcolmo, Margareth, Gardiner, Kaya, Gell, Grace, Germano, Susie, Gomes-Silva, Adriano, Goodall, Casey, Gwee, Amanda, Jamieson, Tenaya, Jardim, Bruno, Kollmann, Tobias R., Lacerda, Marcus V. G., Lee, Katherine J., Lucas, Michaela, Lynn, David J., Manning, Laurens, Marshall, Helen S., McDonald, Ellie, Munns, Craig F., Nicholson, Suellen, O’Connell, Abby, Oliveira, Roberto D. de, Perlen, Susan, Perrett, Kirsten P., Prat-Aymerich, Cristina, Richmond, Peter C., Rodríguez-Baño, Jesús, Santos, Glauce dos, Silva, Patricia V. da, Teo, Jia Wei, Villanueva, Paola, Warris, Adilia, Wood, Nicholas J., Davidson, Andrew, Curtis, Nigel, and BRACE Trial Consortium Group

Abstract

[BACKGROUND] The bacille Calmette–Guérin (BCG) vaccine has immunomodulatory “off-target” effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19)., [METHODS] In this international, double-blind, placebo-controlled trial, we randomly assigned health care workers to receive the BCG-Denmark vaccine or saline placebo and followed them for 12 months. Symptomatic Covid-19 and severe Covid-19, the primary outcomes, were assessed at 6 months; the primary analyses involved the modified intention-to-treat population, which was restricted to participants with a negative test for severe acute respiratory syndrome coronavirus 2 at baseline., [RESULTS] A total of 3988 participants underwent randomization; recruitment ceased before the planned sample size was reached owing to the availability of Covid-19 vaccines. The modified intention-to-treat population included 84.9% of the participants who underwent randomization: 1703 in the BCG group and 1683 in the placebo group. The estimated risk of symptomatic Covid-19 by 6 months was 14.7% in the BCG group and 12.3% in the placebo group (risk difference, 2.4 percentage points; 95% confidence interval [CI], −0.7 to 5.5; P=0.13). The risk of severe Covid-19 by 6 months was 7.6% in the BCG group and 6.5% in the placebo group (risk difference, 1.1 percentage points; 95% CI, −1.2 to 3.5; P=0.34); the majority of participants who met the trial definition of severe Covid-19 were not hospitalized but were unable to work for at least 3 consecutive days. In supplementary and sensitivity analyses that used less conservative censoring rules, the risk differences were similar but the confidence intervals were narrower. There were five hospitalizations due to Covid-19 in each group (including one death in the placebo group). The hazard ratio for any Covid-19 episode in the BCG group as compared with the placebo group was 1.23 (95% CI, 0.96 to 1.59). No safety concerns were identified., [CONCLUSIONS] Vaccination with BCG-Denmark did not result in a lower risk of Covid-19 among health care workers than placebo. (Funded by the Bill and Melinda Gates Foundation and others; BRACE ClinicalTrials.gov number, NCT04327206.)

Published
2023

38. Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial

Author

Bill & Melinda Gates Foundation, Minderoo Foundation, Royal Children's Hospital Foundation, Health Services Union New South Wales Branch, Peter Sowerby Foundation, SA Health, Insurance Advisernet Foundation, NAB Foundation, Calvert-Jones Foundation, Modara Pines Charitable Foundation, United Health Foundation, Epworth HealthCare, National Health and Medical Research Council (Australia), Swiss National Science Foundation, Pittet, Laure F., Moore, Cecilia L., McDonald, Ellie, Barry, Simone, Bonten, Marc, Campbell, John, Croda, Julio, Dalcolmo, Margareth, Davidson, Andrew, Douglas, Mark W., Gardiner, Kaya, Gwee, Amanda, Jardim, Bruno, Lacerda, Marcus V. G., Lucas, Michaela, Lynn, David J., Manning, Laurens, Oliveira, Roberto D. de, Perrett, Kirsten P., Prat-Aymerich, Cristina, Richmond, Peter C., Rocha, Jorge L., Rodríguez-Baño, Jesús, Warris, Adilia, Wood, Nicholas J., Messina, Nicole L., Curtis, Nigel, BRACE Trial Consortium Group, Bill & Melinda Gates Foundation, Minderoo Foundation, Royal Children's Hospital Foundation, Health Services Union New South Wales Branch, Peter Sowerby Foundation, SA Health, Insurance Advisernet Foundation, NAB Foundation, Calvert-Jones Foundation, Modara Pines Charitable Foundation, United Health Foundation, Epworth HealthCare, National Health and Medical Research Council (Australia), Swiss National Science Foundation, Pittet, Laure F., Moore, Cecilia L., McDonald, Ellie, Barry, Simone, Bonten, Marc, Campbell, John, Croda, Julio, Dalcolmo, Margareth, Davidson, Andrew, Douglas, Mark W., Gardiner, Kaya, Gwee, Amanda, Jardim, Bruno, Lacerda, Marcus V. G., Lucas, Michaela, Lynn, David J., Manning, Laurens, Oliveira, Roberto D. de, Perrett, Kirsten P., Prat-Aymerich, Cristina, Richmond, Peter C., Rocha, Jorge L., Rodríguez-Baño, Jesús, Warris, Adilia, Wood, Nicholas J., Messina, Nicole L., Curtis, Nigel, and BRACE Trial Consortium Group

Abstract

[Background] Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects., [Methods] In this nested randomised controlled trial within the multicentre, phase 3 BRACE trial, 6828 healthcare workers were randomised in 36 sites in Australia, the Netherlands, Spain, the United Kingdom and Brazil, to receive BCG-Denmark or no BCG (1:1 ratio using a web-based procedure) and followed for 12 months with 3-monthly questionnaires. Exclusion criteria included contraindication to BCG vaccine or previous vaccination with BCG within the past year, any other live-attenuated vaccine within the last month, or any COVID-specific vaccine. The intervention group received one intradermal dose of 0.1 mL of BCG-Denmark corresponding to 2−8 x 105 colony forming units of Mycobacterium bovis, Danish strain 1331. The primary outcome was the difference in restricted mean survival time (i.e., time to first cold-sore recurrence), in participants with frequent recurrent herpes labialis (≥4 recurrences/year), analysed by intention-to-treat. Secondary outcomes addressed additional questions, including analyses in other sub-populations. Adverse events were monitored closely during the first 3 months and were reported in all participants who received one dose of study drug according to intervention received. The BRACE trial is registered with ClinicalTrials.gov, NCT04327206., [Findings] Between March 30, 2020 and February 18, 2021, 84 individuals with frequent recurrent cold sores were randomly assigned to BCG (n = 38) or control (n = 46). The average time to first cold-sore recurrence was 1.55 months longer in the BCG group (95% CI 0.27–2.82, p = 0.02) than the control group (hazard ratio 0.54, 95% CI 0.32–0.91; intention-to-treat). The beneficial effect of BCG was greater in the as-treated population (difference 1.91 months, 95% CI 0.69–3.12, p = 0.003; hazard ratio 0.45, 95% CI 0.26–0.76). In prespecified subgroup analyses, only sex modified the treatment effect (interaction p = 0.007), with benefit restricted to males. Over 12 months, a greater proportion of participants in the BCG group compared with the control group reported a decrease in duration (61% vs 21%), severity (74% vs 21%), frequency (55% vs 21%), and impact on quality of life (42% vs 15%) of cold sore recurrences. In participants who had ever had a cold sore, there was also a decrease in self-reported burden of recurrences in the BCG group. In participants who had never had a cold sore, there was an increased risk of a first episode in the BCG group (risk difference 1.4%; 95% CI 0.3–2.6%, p = 0.02). There were no safety concerns., [Interpretation] BCG-Denmark vaccination had a beneficial effect on herpes labialis, particularly in males with frequent recurrences, but may increase the risk of a first cold sore.

Published
2023

41. Severe haemolysis during primaquine radical cure ofPlasmodium vivaxmalaria: two systematic reviews and individual patient data descriptive analyses

Author

Yilma, Daniel, primary, Groves, Emily S, additional, Brito-Sousa, Jose Diego, additional, Monteiro, Wuelton M, additional, Chu, Cindy, additional, Thriemer, Kamala, additional, Commons, Robert J, additional, Lacerda, Marcus V G, additional, Price, Ric N, additional, and Douglas, Nicholas M, additional

Published
2023
Full Text
View/download PDF

43. Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2)

Author

Bittencourt, Najara C., Leite, Juliana A., Silva, Ana Beatriz I. E., Pimenta, Tamirys S., Silva-Filho, João Luiz, Cassiano, Gustavo C., Lopes, Stefanie C. P., dos-Santos, Joao C. K., Bourgard, Catarina, Nakaya, Helder I., da Silva Ventura, Ana Maria Revorêdo, Lacerda, Marcus V. G., Ferreira, Marcelo U., Machado, Ricardo L. D., Albrecht, Letusa, and Costa, Fabio T. M.

Published
2018
Full Text
View/download PDF

44. The genome of the brackish-water malaria vectorAnopheles aquasalis

Author

Sepulveda, Cesar C. P., primary, Alencar, Rodrigo M., additional, Martinez-Villegas, Luiz, additional, Bahia, Ana Cristina, additional, Santana, Rosa A., additional, de Souza, Igor B., additional, D’Elia, Gigliola M. A., additional, Duarte, Ana Paula M., additional, de Lacerda, Marcus V. G., additional, Monteiro, Wuelton M., additional, F. Costa Secundino, Nágila, additional, Koerich, Leonardo B., additional, and Pimenta, Paulo F. P., additional

Published
2022
Full Text
View/download PDF

47. On the Cytoadhesion of Plasmodium vivax —Infected Erythrocytes

Author

Carvalho, Bruna O., Lopes, Stefanie C. P., Nogueira, Paulo A., Orlandi, Patricia P., Bargieri, Daniel Y., Blanco, Yara C., Mamoni, Ronei, Leite, Juliana A., Rodrigues, Mauricio M., Soares, Irene S., Oliveira, Tatiane R., Wunderlich, Gerhard, Lacerda, Marcus V. G., Portillo, Hernando A. del, Araújo, Maria O. G., Russell, Bruce, Suwanarusk, Rossarin, Snounou, Georges, Rénia, Laurent, and Costa, Fabio T. M.

Published
2010

48. Bilateral buttock eosinophilic cellulitis after intramuscular benzathine penicillin injection.

Author

Borba, Mayla G. S., Baía‐da‐Silva, Djane C., Fabricio, Dina, Almeida, Gabriela, dos Reis, Monique F., Mendes, Luciana, Lacerda, Marcus V. G., and Safe, Izabella P.

Subjects
CELLULITIS, SYPHILIS, INTRAMUSCULAR injections, BUTTOCKS, PENICILLIN, SKIN diseases
Abstract

This article discusses a case of bilateral buttock eosinophilic cellulitis (EC) that developed after an intramuscular benzathine penicillin injection for syphilis treatment. EC is a rare inflammatory skin disease characterized by erythematous skin lesions with eosinophils extending to subcutaneous tissue. It is often mistaken for bacterial cellulitis but does not respond to antimicrobial therapy. The case highlights the importance of recognizing and properly diagnosing EC, as well as the need for surveillance of adverse events associated with intramuscular injections. Treatment typically involves systemic corticosteroids. [Extracted from the article]

Published
2024
Full Text
View/download PDF

49. Real-life quantitative G6PD screening in Plasmodium vivax patients in the Brazilian Amazon: A cost-effectiveness analysis

Author

Brito-Sousa, Jose Diego, primary, Peixoto, Henry M., additional, Devine, Angela, additional, Silva-Neto, Alexandre V., additional, Balieiro, Patricia C. S., additional, Sampaio, Vanderson S., additional, Vitor-Silva, Sheila, additional, Mendes, Maxwell O., additional, Souza, Brenda K. A., additional, Lacerda, Marcus V. G., additional, and Monteiro, Wuelton M., additional

Published
2022
Full Text
View/download PDF

50. Influence of CYP2D6, CYP3A4 and CYP2C19 Genotypes on Recurrence of Plasmodium vivax

Author

Cardoso, Jaiana L. M., primary, Salazar, Yanka E. A. R., additional, Almeida, Anne C. G., additional, Barbosa, Laila R. A., additional, Silva, Emanuelle L., additional, Rodrigues, Maria Gabriela Almeida, additional, Rodrigues-Soares, Fernanda, additional, Sampaio, Vanderson S., additional, Siqueira, André M., additional, Lacerda, Marcus V. G., additional, Monteiro, Wuelton M., additional, and Melo, Gisely C., additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results