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2. Comments to Marvel Fusions Mixed Fuels Reactor Concept

Author

Lackner, Karl, Burhenn, Rainer, Fietz, Sina, and von Müller, Alexander

Subjects
Physics - Plasma Physics
Abstract

Nanostructured solid boron-hydrogen compounds have been suggested as target and fuel for laser fusion, offering improved laser-plasma coupling, avoiding cryogenic fuel handling and fuel pre-compression and ultimately allowing a transit from DT- to aneutronic pB- fusion power production. We describe the scaling of the different energy loss channels ({\alpha}-particle escape, bremsstrahlung, hydrodynamic expansion work, electron heat conduction) with mixed fuel composition using partial inverse gains (Q's) which allow a simple superposition of losses. This highlights in particular the negative synergy between these loss-channels for such mixed fuels: the dominance of bremsstrahlung over fusion power at low temperatures forces a shift of operation to higher ones, where the plasma gets more transparent to {\alpha}-particles, and hydrodynamic and heat conduction losses increase strongly. The use of mixed fuels therefore does not eliminate the need for strong precompression of the fuel: in fact, it renders achieving burning plasma conditions much more difficult, if not impossible. A recent suggestion to use tamping of the fuel by cladding with a heavy metal would only reduce hydrodynamic expansion losses significantly if the cladding could cover most of the fuel surface, in competition with access to laser radiation. But even if tamping were perfect, this would not reduce the remaining three loss channels - in fact it would have a negative effect on burn propagation, as the escaping energy would not heat surrounding fuel, but only the cladding material., Comment: 19 pages, 9 figures; affiliation of authors added in revised version

Published
2023

5. Comments on 'Volume ignition of mixed fuel' by H. Ruhl and G. Korn (Marvel Fusion, Munich)

Author

Lackner, Karl, Burhenn, Rainer, Fietz, Sina, and von Müller, Alexander

Subjects
Physics - Plasma Physics
Abstract

In the most recent note on Marvel Fusion's concept for a laser driven pB reactor without compression, Ruhl and Korn consider the volumetric energy balance of fusion reactions vs. bremsstrahlung losses in a mixed fuel (DT and pB) environment and claim the satisfaction of this necessary "ideal ignition" condition. Their results are based, however, on improper assumptions about the deposition of fusion energy in the plasma. Correcting for them, we show that the quoted composition of their fuel (a solid boron composite, binding high concentrations of D, T and p) would actually preclude ignition due to the high bremsstrahlung losses associated with the presence of boron. To facilitate ignition, Ruhl and Korn also consider the reduction of the bremsstrahlung losses by confining the radiation in the optically thin fuel region by high Z walls. They suggest to preload this region with radiation so that the radiation temperature equals approximately that of the plasma constituents $T_{r} \approx T_{e} \approx T_{i}$. We show that in this set-up the radiation energy - neglected in these considerations - would, however, vastly exceed the thermal energy of the plasma and actually dominate the ignition energy requirements., Comment: 6 pages, 1 figure

Published
2023

9. How well can VMEC predict the initial saturation of external kink modes in near circular tokamaks and $l=2$ stellarators?

Author

Ramasamy, Rohan, Hoelzl, Matthias, Henneberg, Sophia, Strumberger, Erika, Lackner, Karl, and Günter, Sibylle

Subjects
Physics - Plasma Physics
Abstract

The equilibrium code, VMEC, is used to study external kinks in low $\beta$ tokamaks and $l=2$ stellarators. The applicability of the code when modelling nonlinear MHD effects is explored in an attempt to understand and predict how the initial saturation of the MHD mode depends on the external rotational transform. It is shown that helicity preserving, free boundary VMEC computations do not converge to a single perturbed solution with increasing spectral resolution. Additional constraints are therefore applied to narrow down the numerical resolution parameters appropriate for physical scans. The dependence of the modelled (4, 1) kink mode on the external rotational transform and field periodicity is then studied. While saturated states can be identified which decrease in amplitude with increasing external rotational transform, bifurcated states are found that contradict this trend. It was therefore not possible to use VMEC alone to identify the physical dependency of the nonlinear mode amplitude on the magnetic geometry. The accuracy of the VMEC solutions is nevertheless demonstrated by showing that the expected toroidal mode coupling is captured in the magnetic energy spectrum for stellarator cases. Comparing with the initial value code, JOREK, the predicted redistribution of poloidal magnetic energy from the vacuum to plasma region in VMEC is shown to be physical. This work is a first step towards using VMEC to study MHD modes in stellarator geometry., Comment: Submitted to Physics of Plasmas. The submission has been modified according to reviewer comments

Published
2023
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10. Comments to 'High current ionic flows via ultra-fast lasers for fusion applications' by H. Ruhl and G. Korn (Marvel Fusion, Munich)

Author

Lackner, Karl, Fietz, Sina, and Müller, Alexander v.

Subjects
Physics - Plasma Physics
Abstract

We comment on Marvel Fusion's proposal to use ultra-short, intensive laser pulses impinging on nanostructured targets for the production of hot ions, with the ultimate aim of energy production through the p-11B fusion reaction. We show how a minimum requirement on the line density of the heated region arises also for such schemes aiming at ignition or just beam-energy amplification, which already for the D-T reaction are prohibitive if no pre-compression of the target is foreseen. We conclude that advanced ultra-short laser pulses can be of use for fusion applications only if the fusion reaction time can be brought down to sufficiently short values. This can happen only via strong pre-compression of the target, which appears difficult to reconcile with a nanostructured target and in particular with the fuel assembly geometries shown by the proponents., Comment: 5 pages, no figures

Published
2023

11. MHD simulations of formation, sustainment and loss of Quiescent H-mode in the all-tungsten ASDEX Upgrade

Author

Meier, Lorenz, Hoelzl, Matthias, Cathey, Andres, Huijsmans, Guido, Viezzer, Eleonora, Dunne, Mike, van Dijk, Jan, Zabala, Diego José Cruz, Lackner, Karl, Günter, Sibylle, Team, ASDEX Upgrade, Team, EUROfusion MST1, and Team, JOREK

Subjects
Physics - Plasma Physics
Abstract

Periodic edge localized modes (ELMs) are the non-linear consequences of pressure-gradient-driven ballooning modes and current-driven peeling modes becoming unstable in the pedestal region of high confinement fusion plasmas. In future tokamaks like ITER, large ELMs are foreseen to severely affect the lifetime of wall components as they transiently deposit large amounts of heat onto a narrow region at the divertor targets. Several strategies exist for avoidance, suppression, or mitigation of these instabilities, such as the naturally ELM-free quiescent H-mode (QH-mode). In the present article, an ASDEX Upgrade equilibrium that features a QH-mode is investigated through non-linear extended MHD simulations covering the dynamics over tens of milliseconds. The equilibrium is close to the ideal peeling limit and non-linearly develops saturated modes at the edge of the plasma. A dominant toroidal mode number of $n=1$ is found, for which the characteristic features of the edge harmonic oscillation are recovered. The saturated modes contribute to heat and particle transport preventing pedestal build-up to the ELM triggering threshold. The non-linear dynamics of the mode, in particular its interaction with the evolution of the edge safety factor is studied, which suggest a possible new saturation mechanism for the QH-mode. The simulations show good qualitative and quantitative agreement to experiments in AUG. In particular, the processes leading to the termination of QH-mode above a density threshold is studied, which results in the transition into an ELM regime. In the vicinity of this threshold, limit cycle oscillations are observed., Comment: Revised version with modifications from review process included

Published
2023
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13. Comments to 'A non-thermal laser-driven mixed fuel nuclear fusion reactor concept' by H. Ruhl and G. Korn (Marvel Fusion, Munich)

Author

Lackner, Karl

Subjects
Physics - Plasma Physics
Abstract

The declared aim of Marvel Fusion is the realization of a reactor based on the aneutronic fusion of proton and boron-11 nuclei in the near future, making use of latest-day laser technology and nano-structured materials. The aim of the preprint quoted above is to demonstrate the feasibility of fusion energy gain from the irradiation of an initially uncompressed target consisting of an array of nano-wires, by a femto-second laser. This proposal is in apparent contrast to text-book wisdom, which postulates - even for the fast-ignitor concept, and a DT fuel mix - a target density about 1000 times that of solid state. The novel, optimistic predictions of Ruhl and Korn are based, however, not on rigorous estimates, but only on parametric dependencies, extrapolated far beyond their conventional limits of validity. The authors invoke the effects of self-arising magnetic fields to result in additional magnetic confinement, but we show their model to contain intrinsic contradictions. The conclusion from out note is that ultra-fast, high power lasers can be of use to inertial fusion energy production only, if the intrinsic time-scale for fusion reactions can be brought down to a level more commensurate with the Laser pulse length. Involving magnetic fields does not change this basic limitation, as the Alfv\'en time will be similar to the kinetic disintegration time. Given that the fusion energy gain as function of particle energy has a maximum (for DT at about 170 keV) overheating will not be helpful so that the required enhancement of the fusion reaction rate can only be achieved by strong pre-compression of the target.

Published
2022

14. Modelling of saturated external MHD instabilities in tokamaks: a comparison of 3D free boundary equilibria and nonlinear stability calculations

Author

Ramasamy, Rohan, Ramirez, Guillermo Bustos, Hoelzl, Matthias, Graves, Jonathan, López, Guillermo Suárez, Lackner, Karl, Günter, Sibylle, and team, the JOREK

Subjects
Physics - Plasma Physics
Abstract

3D free boundary equilibrium computations have recently been used to model external kinks and edge harmonic oscillations (EHOs), comparing with linear MHD stability codes, and nonlinear analytic theory [Kleiner et al, PPCF 61 084005 (2019)]. In this study, results of the VMEC equilibrium code are compared further with nonlinear reduced MHD simulations, using the JOREK code. The purpose of this investigation is to understand the extent to which the modelling approaches agree, and identify the important physical effects which can modify the dynamics. For the simulated external kink, which is dominated by a single toroidal harmonic, good agreement is found when a large Lundquist number is used in the JOREK simulation, such that resistive effects are sub-dominant. Modelling EHOs where multiple toroidal harmonics are linearly unstable, the saturated perturbation observed can differ in the dominant toroidal harmonic. On the ideal timescale, a n=2 EHO is observed in JOREK, while the saturated perturbation predicted by VMEC is a n=1 mode. Extending simulations into timescales where resistive effects can play a role, similar n=1 perturbations can be found. The coupling of different linearly unstable toroidal harmonics in the JOREK simulation broadens the magnetic energy spectrum and ergodises the plasma edge region, resulting in a more localised pressure perturbation. These effects are not observed in VMEC, because closed magnetic flux surfaces are enforced. Despite the sensitivity of JOREK results on the assumed resistivity, saturated states can be found using both approaches that are in reasonable agreement, even for this more advanced case., Comment: Submitted to Physics of Plasmas, with revisions from review process included

Published
2022
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16. JOREK3D: An extension of the JOREK nonlinear MHD code to stellarators

Author

Nikulsin, Nikita, Ramasamy, Rohan, Hoelzl, Matthias, Hindenlang, Florian, Strumberger, Erika, Lackner, Karl, and Günter, Sibylle

Subjects
Physics - Plasma Physics, Physics - Computational Physics
Abstract

Although the basic concept of a stellarator was known since the early days of fusion research, advances in computational technology have enabled the modelling of increasingly complicated devices, leading up to the construction of Wendelstein 7-X, which has recently shown promising results. This recent success has revived interest in the nonlinear 3D MHD modelling of stellarators in order to better understand their performance and operational limits. This paper reports on the extension of the JOREK code to 3D geometries and on the first stellarator simulations carried out with it. The first simple simulations shown here address the classic Wendelstein 7-A stellarator using a reduced MHD model previously derived by us. The results demonstrate that stable full MHD equilibria are preserved in the reduced model: the flux surfaces do not move throughout the simulation, and closely match the flux surfaces of the full MHD equilibrium. Further, both tearing and ballooning modes were simulated, and the linear growth rates measured in JOREK are in reasonable agreement with the growth rates from the CASTOR3D linear MHD code., Comment: 16 pages, 12 figures. Based mostly on the last chapter of the first author's doctoral thesis, with some data new data that was not included in the thesis. The article was submitted to Physics of Plasmas

Published
2022
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18. Prevalence of current suicidal thoughts and lifetime suicide attempts in individuals with cancer and other chronic diseases in Germany: Evidence for differential associations from a representative community cohort

Author

Schwinn, Tamara, Paul, Roman H., Hirschmiller, Judith, Brähler, Elmar, Wiltink, Jörg, Zwerenz, Rüdiger, O'Connor, Rory C., Wild, Philipp S., Münzel, Thomas, König, Jochem, Geschke, Katharina, Moehler, Markus, Konstantinides, Stavros, Justenhoven, Christina, Lackner, Karl J., Pfeiffer, Norbert, Beutel, Manfred E., and Ernst, Mareike

Published
2024
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21. Effects of empagliflozin on left ventricular diastolic function in addition to usual care in individuals with type 2 diabetes mellitus—results from the randomized, double-blind, placebo-controlled EmDia trial

Author

Prochaska, Jürgen H., Jünger, Claus, Schulz, Andreas, Arnold, Natalie, Müller, Felix, Heidorn, Marc William, Baumkötter, Rieke, Zahn, Daniela, Koeck, Thomas, Tröbs, Sven-Oliver, Lackner, Karl J., Daiber, Andreas, Binder, Harald, Shah, Sanjiv J., Gori, Tommaso, Münzel, Thomas, and Wild, Philipp S.

Published
2023
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23. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Author

Phelps, Nowell H, Singleton, Rosie K, Zhou, Bin, Heap, Rachel A, Mishra, Anu, Bennett, James E, Paciorek, Christopher J, Lhoste, Victor PF, Carrillo-Larco, Rodrigo M, Stevens, Gretchen A, Rodriguez-Martinez, Andrea, Bixby, Honor, Bentham, James, Di Cesare, Mariachiara, Danaei, Goodarz, Rayner, Archie W, Barradas-Pires, Ana, Cowan, Melanie J, Savin, Stefan, Riley, Leanne M, Aguilar-Salinas, Carlos A, Baker, Jennifer L, Barkat, Amina, Bhutta, Zulfiqar A, Branca, Francesco, Caixeta, Roberta B, Cuschieri, Sarah, Farzadfar, Farshad, Ganapathy, Shubash, Ikeda, Nayu, Iotova, Violeta, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Lin, Hsien-Ho, Ma, Jun, Mbanya, Jean Claude N, Miranda, J Jaime, Pradeepa, Rajendra, Rodríguez-Artalejo, Fernando, Sorić, Maroje, Turley, Maria, Wang, Limin, Webster-Kerr, Karen, Aarestrup, Julie, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdeen, Ziad A, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Abubakar Garba, Jamila, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J, Adu-Afarwuah, Seth, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Ågren, Åsa, Aguenaou, Hassan, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lahou, Badreya, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Al Qaoud, Nawal M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A, Alexius, Sylvia, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkerwi, Ala'a, Alkhatib, Buthaina M, Allin, Kristine, Alomary, Shaker A, Alomirah, Husam F, Alshangiti, Arwa M, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assefa, Nega, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Aung, May Soe, Aurélio de Valois, Correia Júnior Marco, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Babu, Bontha V, Bacopoulou, Flora, Bæksgaard Jørgensen, Maja, Baharudin, Azli, Bahijri, Suhad, Bajramovic, Izet, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R, Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz, Bata, Iqbal, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berhane, Yemane, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Berrios Carrasola, Ximena, Bettiol, Heloísa, Beutel, Manfred E, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Biasch, Katia, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Anne A, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Blychfeld Magnazu, Moran, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boer, Jolanda MA, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Botomba, Steve, Bourne, Rupert RA, Bovet, Pascal, Boymatova, Khadichamo, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Braithwaite, Tasanee, Brajkovich, Imperia, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brophy, Sinead, Brug, Johannes, Bruno, Graziella, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de León, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, José, Can, Günay, Cândido, Ana Paula c, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajús, José A, Casanueva, Felipe F, Casas, Maribel, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Angelique, Chan, Queenie, Charchar, Fadi J, Charles, Marie-Aline, Chaturvedi, Himanshu K, Chaturvedi, Nish, Che Abdul Rahim, Norsyamlina, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Cojocaru, Cosmin R, Colorado-Yohar, Sandra, Compañ-Gabucio, Laura-María, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Cortés, Lilia Yadira, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Csányi, Tamás, Csilla, Semánová, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva, Alanna G, Dacica, Liliana, Dahm, Christina C, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Backer, Guy, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, De Neve, Jan-Walter, Duarte de Oliveira, Paula, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, de Sá, Ana Carolina MGN, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent Jr, Delisle, Hélène, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Dereń, Katarzyna, Deschamps, Valérie, Devrishov, Ruslan D, Dhimal, Meghnath, Di Castelnuovo, Augusto, Dias-da-Costa, Juvenal Soares, Díaz-Sánchez, María Elena, Diaz, Alejandro, Díaz Fernández, Pedro, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Dong, Yanhui, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Dörr, Marcus, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duleva, Vesselka L, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dwyer, Terence, Dyussupova, Azhar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ammari, Laila, El Ati, Jalila, Eldemire-Shearer, Denise, Elliott, Paul, Enang, Ofem, Endevelt, Ronit, Engle-Stone, Reina, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Evans, Roger G, Faeh, David, Fagherazzi, Guy, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farrugia Sant'Angelo, Victoria, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Fawzi, Wafaie W, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Gerson, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferreira, Haroldo S, Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Fras, Zlatko, Fraser, Brooklyn, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Gafencu, Mihai, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Gao, Pei, Garcia-de-la-Hera, Manoli, García Mérida, María José, García Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, George, Ronnie, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gieger, Christian, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Gogen, Sibel, Goldberg, Marcel, Goltzman, David, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Leon, Margot, González-Rivas, Juan P, González-Villalpando, Clicerio, González-Villalpando, María-Elena, Gonzalez, Angel R, Gottrand, Frederic, Graça, Antonio Pedro, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregg, Edward W, Gregor, Ronald D, Gregório, Maria João, Grøholt, Else Karin, Grøntved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Guajardo, Viviana, Gualdi-Russo, Emanuela, Guallar-Castillón, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerchet, Maëlenn, Guerrero, Ramiro, Guessous, 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Schröder, Helmut, Schultsz, Constance, Schultz, Gry, Schulze, Matthias B, Schutte, Aletta E, Sebert, Sylvain, Sedaghattalab, Moslem, Selamat, Rusidah, Sember, Vedrana, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Sequera, Guillermo, Serra-Majem, Luis, Servais, Jennifer, Ševčíková, Ľudmila, Sewpaul, Ronel, Shalnova, Svetlana, Shamah-Levy, Teresa, Shamshirgaran, Seyed Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K, Sharman, Almaz, Shaw, Jonathan E, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shimony, Tal, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M, Sidossis, Labros S, Silitrari, Natalia, Silva, Antonio M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Silva, Kelly Samara, Sim, Xueling, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöberg, Agneta, Sjöström, Michael, Skoblina, Elena V, Skoblina, Natalia A, Slazhnyova, Tatyana, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Söderberg, Stefan, Soekatri, Moesijanti YE, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Solovieva, Yuliya V, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Soofi, Sajid, Sørensen, Thorkild IA, Sørgjerd, Elin P, Sossa Jérome, Charles, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sousa-Poza, Alfonso, Sovic, Slavica, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Spencer, Phoebe R, Spinelli, Angela, Spiroski, Igor, Staessen, Jan A, Stamm, Hanspeter, Stang, Andreas, Starc, Gregor, Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Steinsbekk, Silje, Stergiou, George S, Stessman, Jochanan, Stevanović, Ranko, Stieber, Jutta, Stöckl, Doris, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Sturua, Lela, Suárez-Medina, Ramón, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Sugiyama, Mindy, Suka, Machi, Sulo, Gerhard, Sun, Chien-An, Sun, Liang, Sund, Malin, Sundström, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Sweis, Nabil William G, Swinburn, Boyd A, Sy, Rody G, Sylva, René Charles, Szponar, Lucjan, Tabone, Lorraine, Tai, E Shyong, Takuro, Furusawa, Tambalis, Konstantinos D, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanrygulyyeva, Maya, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Taxová Braunerová, Radka, Taylor, Anne, Taylor, Julie, Tchibindat, Félicité, Te Velde, Saskia, Tebar, William R, Tell, Grethe S, Tello, Tania, Tessema, Masresha, Tham, Yih Chung, Thankappan, KR, Theobald, Holger, Theodoridis, Xenophon, Thomas, Nihal, Thorand, Barbara, Thrift, Amanda G, Tichá, Ľubica, Timmermans, Erik J, Tjandrarini, Dwi Hapsari, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Tomaszewski, Maciej, Topbas, Murat, Topór-Mądry, Roman, Torheim, Liv Elin, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Tremblay, Mark S, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsintavis, Panagiotis, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Twig, Gilad, Tynelius, Per, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Udoji, Nwannedimma, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Varona-Pérez, Patricia, Vasan, Senthil K, Vasques, Daniel G, Vatasescu, Radu, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Viriyautsahakul, Napaphan, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Vourli, Georgia, Voutilainen, Ari, Vrijheid, Martine, Vrijkotte, Tanja GM, Vuletić, Silvije, Wade, Alisha N, Waldhör, Thomas, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid

Published
2024
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24. Nonlinear MHD simulations of external kinks in quasi-axisymmetric stellarators using an axisymmetric external rotational transform approximation

Author

Ramasamy, Rohan, Hoelzl, Matthias, Strumberger, Erika, Lackner, Karl, and Günter, Sibylle

Subjects
Physics - Plasma Physics
Abstract

Reduced magnetohydrodynamic (MHD) equations are used to study the nonlinear dynamics of external kinks in a quasi-axisymmetric (QA) stellarator with varying fractions of external rotational transform. The large bootstrap currents associated with high beta plasmas may make QA configurations susceptible to low n external modes, limiting their operational space. The violence of the nonlinear dynamics, and, in particular, when these modes lead to a disruption, is not yet understood. In this paper, the nonlinear phase of external kinks in an unstable QA configuration with an edge safety factor below two is simulated. An axisymmetric approximation of this stellarator is constructed in the nonlinear MHD code, JOREK, capturing the influence of the external rotational transform. The use of this approximation for the considered stellarator is validated by comparing the linear dynamics against the linear viscoresistive MHD code, CASTOR3D. The nonlinear dynamics of this stellarator approximation are compared with an equivalent tokamak to understand the influence of a relatively small external rotational transform. While the external rotational transform does have a stabilising influence on the MHD activity, it remains violent. To explore the first order influence of a larger external rotational transform, this equilibrium parameter is artificially increased for the considered stellarator, reducing the effective plasma current. The violence of the kink instability is quantified, and shown to reduce with the increasing external rotational transform. At the same time, the external kink triggers internal modes that exacerbate the loss in confinement during the nonlinear phase, such that it remains large over much of the parameter space. It is only with a significant fraction of external rotational transform that these subsequent modes are stabilised., Comment: This article has been submitted to Nuclear Fusion. This version includes revisions to take into account reviewer comments

Published
2021
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25. Testing of the new JOREK stellarator-capable model in the tokamak limit

Author

Nikulsin, Nikita, Hoelzl, Matthias, Zocco, Alessandro, Lackner, Karl, and Guenter, Sibylle

Subjects
Physics - Plasma Physics
Abstract

In preparation for extending the JOREK nonlinear MHD code to stellarators, a hierarchy of stellarator-capable reduced and full MHD models has been derived and tested. The derivation was presented at the EFTC 2019 conference. Continuing this line of work, we have implemented the reduced MHD model (arXiv:1907.12486) as well as an alternative model which was newly derived using a different set of projection operators for obtaining the scalar momentum equations from the full MHD vector momentum equation. With the new operators, the reduced model matches the standard JOREK reduced models for tokamaks in the tokamak limit and conserves energy exactly, while momentum conservation is less accurate than in the original model whenever field-aligned flow is present., Comment: 23 pages, 1 table, 7 figures. Submitted to Journal of Plasma Physics

Published
2020
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27. Circulating microRNAs predict recurrence and death following venous thromboembolism

Author

ten Cate, Vincent, Rapp, Steffen, Schulz, Andreas, Pallares Robles, Alejandro, Jurk, Kerstin, Koeck, Thomas, Espinola-Klein, Christine, Halank, Michael, Seyfarth, Hans-Jürgen, Beutel, Manfred E., Schuster, Alexander K., Marini, Federico, Hobohm, Lukas, Lankeit, Mareike, Lackner, Karl J., Ruf, Wolfram, Münzel, Thomas, Andrade-Navarro, Miguel A., Prochaska, Jürgen H., Konstantinides, Stavros V., and Wild, Philipp S.

Published
2023
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30. A three-dimensional reduced MHD model consistent with full MHD

Author

Nikulsin, Nikita, Hoelzl, Matthias, Zocco, Alessandro, Lackner, Karl, and Günter, Sibylle

Subjects
Physics - Plasma Physics
Abstract

Within the context of a viscoresistive magnetohydrodynamic (MHD) model with anisotropic heat transport and cross-field mass diffusion, we introduce novel three-term representations for the magnetic field (background vacuum field, field line bending and field compression) and velocity ($\vec E\times\vec B$ flow, field-aligned flow and fluid compression), which are amenable to three-dimensional treatment. Once the representations are inserted into the MHD equations, appropriate projection operators are applied to Faraday's law and the Navier-Stokes equation to obtain a system of scalar equations that is closed by the continuity and energy equations. If the background vacuum field is sufficiently strong and the $\beta$ is low, MHD waves are approximately separated by the three terms in the velocity representation, with each term containing a specific wave. Thus, by setting the appropriate term to zero, we eliminate fast magnetosonic waves, obtaining a reduced MHD model. We also show that the other two velocity terms do not compress the magnetic field, which allows us to set the field compression term to zero within the same reduced model. Dropping also the field-aligned flow, a further simplified model is obtained, leading to a fully consistent hierarchy of reduced and full MHD models for 3D plasma configurations. Finally, we discuss the conservation properties and derive the conditions under which the reduction approximation is valid. We also show that by using an ordering approach, reduced MHD equations similar to what we got from the ansatz approach can be obtained by means of a physics-based asymptotic expansion., Comment: 18 pages. This article was published in Physics of Plasmas

Published
2019
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32. Numerical study of tearing mode seeding in tokamak X-point plasma

Author

Meshcheriakov, Dmytro, Hoelzl, Matthias, Igochine, Valentin, Fietz, Sina, Orain, Francois, Huijsmans, Guido T. A., Maraschek, Marc, Dunne, Mike, McDermott, Rachael, Zohm, Hartmut, Lackner, Karl, Guenter, Sibylle, Team, ASDEX Upgrade, and Team, EUROfusion MST1

Subjects
Physics - Plasma Physics, Physics - Computational Physics
Abstract

A detailed understanding of island seeding is crucial to avoid (N)TMs and their negative consequences like confinement degradation and disruptions. In the present work, we investigate the growth of 2/1 islands in response to magnetic perturbations. Although we use externally applied perturbations produced by resonant magnetic perturbation (RMP) coils for this study, results are directly transferable to island seeding by other MHD instabilities creating a resonant magnetic field component at the rational surface. Experimental results for 2/1 island penetration from ASDEX Upgrade are presented extending previous studies. Simulations are based on an ASDEX Upgrade L-mode discharge with low collisionality and active RMP coils. Our numerical studies are performed with the 3D, two fluid, non-linear MHD code JOREK. All three phases of mode seeding observed in the experiment are also seen in the simulations: first a weak response phase characterized by large perpendicular electron flow velocities followed by a fast growth of the magnetic island size accompanied by a reduction of the perpendicular electron velocity, and finally the saturation to a fully formed island state with perpendicular electron velocity close to zero. Thresholds for mode penetration are observed in the plasma rotation as well as in the RMP coil current. A hysteresis of the island size and electron perpendicular velocity is observed between the ramping up and down of the RMP amplitude consistent with an analytically predicted bifurcation. The transition from dominant kink/bending to tearing parity during the penetration is investigated.

Published
2019
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33. Severe high-molecular-weight kininogen deficiency: clinical characteristics, deficiency–causing KNG1 variants, and estimated prevalence

Author

Adenaeuer, Anke, Barco, Stefano, Trinchero, Alice, Krutmann, Sarah, Nazir, Hanan Fawzy, Ambaglio, Chiara, Rocco, Vincenzo, Pancione, Ylenia, Tomao, Luigi, Ruiz-Sáez, Arlette, Echenagucia, Marion, Alesci, Sonja, Sollfrank, Stefanie, Ezigbo, Eyiuche D., Häuser, Friederike, Lackner, Karl J., Lämmle, Bernhard, and Rossmann, Heidi

Published
2023
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35. FRI-194-YI Risk of all-cause mortality and adverse outcomes from steatotic liver disease and its subgroups in the general population

Author

Michel, Maurice, primary, Armandi, Angelo, additional, Gieswinkel, Alexander, additional, Schuster, Alexander, additional, Muenzel, Thomas, additional, Konstantinides, Stavros, additional, Michal, Matthias, additional, Straub, Beate, additional, Schmidtmann, Irene, additional, Tuescher, Oliver, additional, Wild, Philipp, additional, Lackner, Karl, additional, Galle, Peter R., additional, and Schattenberg, Jörn M, additional

Published
2024
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37. Simulation of the electromagnetic wall response during Vertical Displacement Events (VDE) in ITER tokamak

Author

Atanasiu, Cǎlin V., Zakharov, Leonid E., Lackner, Karl, and Hoelzl, Matthias

Subjects
Physics - Plasma Physics
Abstract

The key basis for tokamak plasma disruption modeling is to understand how currents flow to the plasma facing surfaces during plasma disruption events. In ITER tokamak, the occurrence of a limited number of major disruptions will definitively damage the chamber with no possibility to restore the device. In the current exchange plasma-wall-plasma, according to the Helmholtz decomposition theorem, our surface current density in the conducting shell - the unknown of our problem - being a vector field twice continuously differentiable in 3D, has been splited into two components: an irrotational (curl-free) vector field and a solenoidal (divergence-free) vector field. Developing a weak formulation form and minimizing the correspondent energy functionals in a Finite Element approach, we have obtained the space and time distribution of the surface currents. We verified successfully our numerical simulation with an analytical solution with pure homogeneous Neumann B.C. and satisfying the necessary existence condition. By considering the iron core presence in JET tokamak, we have split the magnetization currents - the unknowns in some integral equations - into two components, the first producing a magnetic field in the iron region only and the second producing a magnetic field in the vacuum, obtaining thus a better evaluation of the influence of the iron core on the plasma equilibrium. To reduce the influence of the singularities appearing during the surface currents determination in multiply connected domains (L-shaped domains) we have used a conformal transformation method., Comment: 9 pages, 7 figures, 7$^{th}$ Int'l Conference on Mathematical Modeling in Physical Sciences, Moscow, Russia

Published
2018
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39. Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study

Author

Schmitt, Volker H., Leuschner, Anja, Jünger, Claus, Pinto, Antonio, Hahad, Omar, Schulz, Andreas, Arnold, Natalie, Tröbs, Sven-Oliver, Panova-Noeva, Marina, Keller, Karsten, Zeller, Tanja, Beutel, Manfred, Pfeiffer, Norbert, Strauch, Konstantin, Blankenberg, Stefan, Lackner, Karl J., Prochaska, Jürgen H., Wild, Philipp S., and Münzel, Thomas

Published
2022
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40. Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis

Author

Pallares Robles, Alejandro, ten Cate, Vincent, Schulz, Andreas, Prochaska, Jürgen H., Rapp, Steffen, Koeck, Thomas, Panova-Noeva, Marina, Heitmeier, Stefan, Schwers, Stephan, Leineweber, Kirsten, Seyfarth, Hans-Jürgen, Opitz, Christian F., Spronk, Henri, Espinola-Klein, Christine, Lackner, Karl J., Münzel, Thomas, Andrade-Navarro, Miguel A., Konstantinides, Stavros V., ten Cate, Hugo, and Wild, Philipp S.

Published
2022
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44. A kinetic study of fusion burn waves in compressed deuterium-tritium and proton-boron plasmas.

Author

Lavell, Michael J., Kish, Ayden J., Sexton, Andrew T., Evans, Eugene S., Mohammad, Ibrahim, Gomez-Ramirez, Sara, Scullin, William, Borscz, Marcus, Pikuz, Sergey, Mehlhorn, Thomas A., Tabak, Max, Ainsworth, Greg, Sefkow, Adam B., Weng, Suming, and Lackner, Karl

Subjects
NUCLEAR reactions, PLASMA physics, RADIATION, NEUTRON temperature, THERMAL electrons, BREMSSTRAHLUNG, INERTIAL confinement fusion
Abstract

This article presents a kinetic study of fusion burn waves in compressed deuterium-tritium and proton-boron plasmas. The study uses particle-in-cell simulations with Monte Carlo collisions to analyze the energy balance in the expansion of a hot-spot, capturing alpha particle heating and radiative losses. The simulations show that the energy radiated by the hot-spot is recaptured by the surrounding high-density fuel, resulting in a net fusion energy production that is twice the initial hot-spot energy. The study provides insights into the feasibility of proton-boron fusion as an alternative fusion fuel. The given text describes a simulation model for studying Coulomb collisions, fusion reactions, and bremsstrahlung radiation in high-density, highly-collisional systems. The model uses a binary Monte Carlo collision method to simulate these interactions between particles. The text explains the implementation of bremsstrahlung emission and inverse bremsstrahlung absorption in the simulation model. The model is verified through simulations of bremsstrahlung emission from an electron beam incident on solid boron, laser heating of a hydrogen plasma, and photon emission and absorption in a p-11B plasma. The given text discusses the results of simulations on various plasma scenarios. The simulations include laser heating of a hydrogen plasma, fusion burn waves in compressed DT and p-11B plasmas, and the measurement of radiation and fusion power density in a fully ionized p-11B plasma. The results show close agreement between the simulations and other [Extracted from the article]

Published
2024
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45. Psychometric evaluation of the Brief Resilient Coping Scale (BRCS) over the course of the pandemic in a large German general population sample.

Author

Petersen, Julia, Brähler, Elmar, Hettich-Damm, Nora, Schepers, Markus, König, Jochem, Lackner, Karl, Pfeiffer, Norbert, and Beutel, Manfred E.

Subjects
PSYCHOMETRICS, RELATIONSHIP status, STATISTICAL reliability, TEST validity, SOCIAL support, SOCIAL anxiety
Abstract

Background: The Brief Resilience Coping Scale (BRCS) is a brief instrument suitable for epidemiological studies. The aims of this paper were to analyze changes in BRCS depending on time, sex, age group, relationship status, as well as risk of poverty, to test the psychometric properties including test-retest reliability and measurement invariance, and to determine associations with psychosocial stress, depressiveness, anxiety, social support, as well as subjective mental and physical health. As the data from this study was collected during the pandemic, an additional sensitivity analysis was performed with pre-pandemic data. Methods: A longitudinal study of resilience and distress in a large-sized community sample was performed at one pre-pandemic (T0) and three pandemic time points (T1-3). Resilient coping was assessed by the 4-Item short form of the BRCS, distress by the PHQ-9 and GAD-2. Results: BRCS decreased between the first and the second and increased at the third pandemic time point. The scale had a good internal consistency. Test-retest correlation coefficients ranged from 0.527 to 0.589. Higher resilient coping was found in younger participants, participants not at-risk-of-poverty and in males. Stability was higher in those with a partner, and at-risk-of-poverty. Significant negative associations with psychosocial stress, loneliness, depressiveness, anxiety, social support, as well as subjective and physical health and SES underscored the construct validity. Conclusion: Overall, findings underscore that resilient coping is a dynamic construct with considerable stability. The scale showed good psychometric properties including test-retest reliability over four months to two years. We found that it is not only important to describe the level of resilient coping, but also its stability. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome.

Author

Müller-Calleja, Nadine, Ruf, Wolfram, and Lackner, Karl J.

Subjects
PHOSPHOLIPIDS, AUTOANTIBODIES, ENDOTHELIUM, CLINICAL pathology, AUTOIMMUNE diseases, ANTIPHOSPHOLIPID syndrome
Abstract

The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of pathogenic antiphospholipid antibodies (aPL). Since approximately 30 years ago, lipid-binding aPL, which do not require a protein cofactor, have been regarded as irrelevant for APS pathogenesis even though anticardiolipin are a diagnostic criterion of APS. In this review, we will summarize the available evidence from in vitro studies, animal models, and epidemiologic studies, which suggest that this concept is no longer tenable. Accordingly, we will only briefly touch on the role of other aPL in APS. This topic has been amply reviewed in detail elsewhere. We will discuss the consequences for laboratory diagnostics and future research required to resolve open questions related to the pathogenic role of different aPL specificities. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Numerical simulations of the Princeton magneto-rotational instability experiment with conducting axial boundaries

Author

Wei, Xing, Ji, Hantao, Goodman, Jeremy, Ebrahimi, Fatima, Gilson, Erik, Jenko, Frank, and Lackner, Karl

Subjects
Physics - Fluid Dynamics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Plasma Physics
Abstract

We investigate numerically the Princeton magneto-rotational instability (MRI) experiment and the effect of conducting axial boundaries or endcaps. MRI is identified and found to reach a much higher saturation than for insulating endcaps. This is probably due to stronger driving of the base flow by the magnetically rather than viscously coupled boundaries. Although the computations are necessarily limited to lower Reynolds numbers ($\Re$) than their experimental counterparts, it appears that the saturation level becomes independent of $\Re$ when $\Re$ is sufficiently large, whereas it has been found previously to decrease roughly as $\Re^{-1/4}$ with insulating endcaps. The much higher saturation levels will allow for the first positive detection of MRI beyond its theoretical and numerical predictions.

Published
2016
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50. Obesity‐related inflammatory protein signature in cardiovascular clinical outcomes: results from the Gutenberg Health Study

Author

Panova‐Noeva, Marina, primary, Koeck, Thomas, additional, Schoelch, Corinna, additional, Schulz, Andreas, additional, Prochaska, Jürgen H., additional, Michal, Matthias, additional, Strauch, Konstantin, additional, Schuster, Alexander K., additional, Lackner, Karl J., additional, Münzel, Thomas, additional, Hennige, Anita M., additional, and Wild, Philipp S., additional

Published
2024
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