Search

This in-vivo study aims to assess pomegranate peel extract (PPE) and Apple Cider Vinegar (ACV) efficacy in disinfecting the necrotic primary teeth root canals. Forty-five primary incisors in thirty children. The treatment was performed under local anesthesia with rubber dam isolation. Sterile paper points were inserted for 60 s to collect the first bacterial swab (S1). Root canal walls were prepared and irrigated with 22 mL within 5 min according to the following groups (randomly with 1:1:1 allocation ratio): Group A: (n = 15) with 5% PPE, Group B: (n = 15) with 5% ACV, and Group C: (n = 15) with 5% sodium hypochlorite (NaOCl). Canals were dried with paper points, and paper point was placed in each canal for 60 s to collect the second bacterial swab (S2). Bacterial colonies were counted after 48-hour incubation at 37 °C and the bacterial counts in the S1 and S2 for each sample were compared using the decimal logarithm. Intra-group comparisons were made using Paired sample t and Wilcoxon signed ranks tests. Between-groups comparisons were made using One-Way ANOVA, Kruskal-Wallis, Mann-Whitney U, and Independent Samples tests. The significance level was set at α = 0.05. PPE demonstrated a 60.43% reduction in CFU count, ACV demonstrated a 51.56% reduction in CFU count, while NaOCl showed an 87.49% reduction in CFU count. Although NaOCl has shown effectiveness in reducing bacterial counts, PPE and ACV have also displayed some antibacterial activity. However, their overall efficacy is less established, which raises questions about their viability as a natural alternative to a 5% NaOCl., Competing Interests: Declarations. Consent for publication: Informed consent was obtained from all children’s parents for the data publication of as part of this study. Competing interests: The authors declare no competing interests. Human Ethics and Consent to Participate declarations: The Research Ethics Committee of the Faculty of Dentistry, Damascus University ethically approved this human-research project (Approval number: (UDDS-2653-14022023/SRC-365)). Informed consent: was obtained from all children’s parents to participate in this trial., (© 2025. The Author(s).)

Dental anxiety usually stands in the way of obtaining adequate dental treatment, and the dental setting and team are considered factors that may affect dental anxiety. Many cross-sectional studies have indicated that dentally anxious children prefer their dentist to wear friendly attire rather than a conventional white coat, but no clinical trial has detected the effect of wearing a child's friendly attire on anxiety levels among young patients. A total of 120 children were enrolled in this study and divided into four groups in which the dentists wore either friendly attire or white coat in the reception and treatment areas. Anxiety and pain were assessed while the patients received a dental injection. A statistically significant decrease in anxiety levels was observed in the 1st group compared with the other three groups after dental infiltration into the maxilla. The pain scores were significantly lower in the 1st group, whereas the control group patients scored the highest scores. A child's friendly attire can help dentists build positive relationships with young patients and help reduce their anxiety., Competing Interests: Declarations. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)

Myeloid sarcoma (MS) is a proliferation of immature myeloid cells that occurs extramedullary, often accompanying acute myeloid leukemia (AML). It typically presents in areas such as lymph nodes, skin, and the head and neck regions. The emergence of MS within the temporal bone is rare, and it can manifest through nonspecific symptoms. In this paper, we reported a case of A 47-year-old female presented with right-sided otalgia, otorrhea, tinnitus, reduced hearing, and ear fullness, and developed facial asymmetry. She was initially diagnosed with necrotizing otitis externa and was treated accordingly. Further investigations were conducted, leading to the diagnosis of MS. She began treatment with induction chemotherapy followed by consolidation therapy. And we reviewed the literature and included 14 MS cases with the same anatomical localization, discussing the primary presentation, immunohistochemistry, and treatment approaches of these patients. In conclusion, temporal bone MS should be considered in patients with a history of AML presenting with nonspecific symptoms. Diagnostic modalities for MS include computed tomography and magnetic resonance imaging scans. Systemic chemotherapy remains the preferred treatment approach. The complexity and diversity of temporal bone MS presentations necessitate further comprehensive research to enhance understanding and improve management strategies for this rare condition., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Background: Dental simulation games are virtual educational games that help children get familiar with different dental procedures. This study aimed to evaluate the pretreatment exposure to the "Baby Panda Dental Care" game in reducing pain and anxiety in comparison with the tell-show-do (TSD) technique during primary molars pulpotomy for patients aged 6-10 years., Materials and Methods: It was a triple-blinded, two-arm, parallel-group, randomized, active-controlled trial. It was done on 60 patients, who were randomly divided into two groups: the control group, TSD technique (n = 30), and the experimental group, "Baby Panda Dental" Care (n = 30). For the TSD technique, children were provided with a verbal explanation followed by a demonstration of the dental treatment in a non-threatening way. The "do" phase is then initiated during performing treatment. For the "Baby Panda dental care" game, children were asked to play for 5 min before treatment, selecting root canal therapy procedures. Pulse rate and RMS pictorial scale were recorded at four time points: (1) at the baseline (t 0 ). (2) After conditioning the child (t 1 ). (3) During treatment (t 2 ). (4) After finishing the treatment (t 3 ). Face, Legs, Activity, Cry, Consolability (FLACC) behavioral pain scale was recorded during treatment (t 2 )., Results: The pulse rate is higher in the control group at t 1 (p = 0.012) and t 2 (p = 0.015). There was a statistically significant difference in the mean RMS pictorial scale score at t 1 (p < 0.001), t 2 (p = 0.006), and t 3 (p < 0.001), a statistically significant difference was noticed in FLACC behavioral pain assessment between the two groups (p = 0.033)., Conclusions: The mobile dental game showed better results than the TSD technique, but neither technique did not reduce anxiety and pain effectively during dental treatment., Trial Registration: The trial was registered at the ISRCTN registry (ISRCTN30470866) on 19/04/2024., (© 2024. The Author(s).)

Hyperplastic pulpitis is an irreversible type of pulpitis that primarily affects young patients. It occurs when an inflamed pulp becomes exposed due to factors such as dental caries, dental trauma, or other causes. Root canal treatment is commonly employed to manage hyperplastic pulpitis. However, vital pulp therapy can be considered as a less invasive option. The main objective of this treatment is to preserve the vitality and functionality of the remaining pulp tissue. This case report discusses the potential management of hyperplastic pulpitis in an immature molar using vital pulp therapy instead of a full root canal treatment. The report includes clinical and radiographic follow-up at six and twelve months., Competing Interests: The authors declare that there are no conflicts of interest., (Copyright © 2024 Anas Mando et al.)

Acquired hemophilia A is a rare bleeding disorder. Rapid diagnosis with prolonged aPTT and low FVIII, and immediate use of bypassing agents and steroids are crucial for better outcomes, highlighting the importance of early recognition and management., Competing Interests: The authors declare no conflict of interest., (© 2024 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)

Objective: This study aimed to assess the clinical and radiographic outcomes of non-instrumentation endodontic treatment (NIET) using a modified antibiotic mix of cefixime, ciprofloxacin and metronidazole with simvastatin (an anti-inflammatory, bone regeneration drug) on necrotic primary molars compared to conventional pulpectomy to help preservation of necrotic primary teeth until its natural exfoliation., Materials and Methods: Forty mandibular primary second molars with necrotic pulp tissue from 38 healthy patients aged between 4 and 8 years were randomly assigned to two groups with a 1:1 allocation ratio. Group A teeth underwent conventional root canal treatment. The procedure involved a two-visit approach, employing k-files and h-files during the initial visit, followed by the application of calcium hydroxide paste as canal dressing between visits, while Group B teeth were treated with 3Mixtatin. All teeth were clinically evaluated after 1, 3, 6, and 12 months, and radiographically at 3, 6, and 12 months. Two external examiners assessed the results. Data analysis was conducted using a chi-square test at a 0.05 significance level., Results: At the end of the follow-up interval, 90% of teeth in each group exhibited no clinical signs or symptoms. Additionally, inter-radicular radiolucency healing occurred in 75% of cases in the NIET group and 89.5% in the conventional pulpectomy group. However, no statistically significant difference was found between the two groups., Conclusion: NIET using 3Mixtatin seems to be a good alternative choice to conventional pulpectomy, offering a less complex treatment approach that may help avoid the complications associated with traditional pulpectomy and could be suitable for teeth with shorter roots., (© 2024 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.)

Background This study was designed to evaluate the effect of apple cider vinegar (ACV) 5% and mechanical plaque removal with a manual toothbrush on dental plaque and gingivitis. The objective was to study available, natural, and inexpensive ways to improve oral health status among the studied group. Materials and methods A randomized clinical trial was performed on 50 children with cerebral palsy aged from three to six years. Participants were divided into two groups (n=25, apple cider vinegar, manual brushing without toothpaste). Plaque accumulation and gingival status were evaluated using Turesky of the Quigley-Hein plaque index (TQHPI) and modified gingival index (MGI) seven times: pre-intervention baseline (T0), post-intervention at one month (T1), two months (T2), three months (T3), four months (T4), five months (T5), six months (T6). Results Plaque accumulation and gingivitis decreased significantly for the ACV group between T0 and T6 (p<0.05) and demonstrated significantly lower plaque accumulation and gingivitis compared to the manual brushing group (p<0.05) at T5 and T6. The manual brushing group showed decreasing in TQHPI between T0 and T3, then TQHPI increased significantly (p<0.05) at T4, T5, and T6. Conclusions To sum up, this in vitro study has demonstrated the possibility of using apple cider vinegar to reduce plaque and gingivitis. In addition, without additives, apple cider vinegar has both mechanical and chemical effects on dental plaque, and it may be a natural, available, inexpensive, and harmless substance that can improve the quality of oral care for difficult groups of children and people with special needs. Unlike toothbrushes, especially electric toothbrushes, they are effective, but they may be expensive and not available to all children., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Asaad et al.)

Background: Apert syndrome (AS) is a rare congenital disorder that correlates with many craniofacial features, like craniosynostosis, midfacial malformation, and symmetrical syndactyly of the hands and feet., Aim: This paper describes the facial and oral manifestations in a 20-year-old female previously diagnosed with AS, discusses the complex dental treatment plan and treatments, including the use of a customized toothbrush handle to enhance the patient's brushing ability., Results: A satisfactory outcome was provided, and the patients quality of life improved significantly due to this comprehensive multi-disciplinary care process., Conclusions: Comprehensive examination, extensive medical history reviewed, parental and patient consent are needed to establish a comprehensive treatment plan regarding the special needs of these patients., Competing Interests: The authors declare no conflict of interest., (© 2022 Published by Elsevier B.V. on behalf of Craniofacial Research Foundation.)

The present study aimed to evaluate the effectiveness of customized handle toothbrush in dental plaque removal in children with Down syndrome in comparison to children with no special needs. A randomized clinical trial was performed on 48 children aged 6-9 years old. Participants were divided into two groups (n = 24, children with no special needs or with Down syndrome). Each group was divided into two subgroups (customized and conventional toothbrush). Plaque accumulation was evaluated using Turesky modification of the Quigley-Hein plaque index (TMQHPI) at four times (pre-brushing (T0), post-brushing at baseline (T1), 1 week (T2) and 3 weeks (T3)), and the modified gingival index (MGI) was used to evaluate the gingivitis at three times (T0, T2 and T3). Data were statistically analyzed. Plaque accumulation and gingivitis decreased significantly for all groups between T0 and T3 ( p < 0.05). Both customized groups demonstrated significant lower plaque accumulation compared to conventional groups ( p < 0.05) at T1, T2 and T3 and significant lower gingivitis at T3. Customizing the toothbrush handle improved child's ability for plaque control, especially in children with Down syndrome.

Background: oral mucositis is one of the most annoying complications of chemotherapy. This randomized clinical trial aimed to assess the efficiency of Aloe Vera and Olive Oil in managing chemotherapy-induced oral mucositis., Methods: 36 children between 6 and 9 years and suffering from grade 3 or 4 oral mucositis, according to the World Health Organization (W.H.O.) scale, were enrolled in this clinical trial. Participants were separated into three groups to treat their mucositis using Aloe Vera, Olive Oil, or sodium bicarbonate. Nurses administrated the agents four times daily with sponge sticks. Two blinded investigators examined the oral mucosa after ten days., Results: Both Aloe Vera and Olive Oil significant differences in the management of chemotherapy-induced oral mucositis compared to sodium bicarbonate treatments., Conclusions: Olive Oil is effective in managing CIOM., Competing Interests: The authors declare no conflict of interest., (© 2021 Craniofacial Research Foundation. Published by Elsevier B.V. All rights reserved.)

Oral mucositis can be caused by chemotherapy and can affect a patient's quality of life. Nowadays, to prevent chemotherapy-induced oral mucositis (CIOM) is a crucial point in palliative care centers. This trial aimed to assess the effectiveness of aloe-vera in that concept. The trial was accomplished at Hematology Department of Hospital of Children of Damascus University, Syria. Acute lymphoblastic leukemia (ALL) children were the population from which 26 children were enrolled in the study. They were aged between 3 and 6 years old and were randomly referred according to the intervention into two groups, Aloe-vera (AV) and sodium bicarbonate 5% (13 each). Spongeous sticks were used to help in applying the material on tongue, labial and buccal mucosa, lips, floor of the mouth, and hard palate. Two blinded external examiners evaluated oral mucosa weekly for up to 2 months using the World Health Organization grading scale. Mann-Whitney U test was used to analyze data. According to the observed findings, CIOM degrees were less severe in the aloe-vera group than in the sodium bicarbonate group. Statistically significant difference of occurrence of different CIOM degrees between groups was recorded in the 2nd, 3rd, 4th, and 7th weeks of follow-up period. Moreover, Mann-Whitney U test indicated that patients in the sodium bicarbonate group began CIOM sooner than those in the aloe-vera group with a statistically significant difference ( p = .001). These findings show that topical application of aloe-vera solution is effective in the prevention of CIOM in ALL children.