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24 results on '"Laganiere, Simon"'

1. Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington's disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial

Author

Adams, Jamie, Beck, Christopher, Chen, Cheryl, Nance, Martha, Testa, Claudia, Huffman, Patricia, Chesire, Amy, Marshall, Frederick, Dayalu, Praveen, Stovall, Angela, Hall, Deborah, Hawkins, Jacob, Ginsburg, Letty, Moore, Henry, Mestre, Tiago, Thompson, Tanya, Connors, Natalie, Rosas, H. Diana, Daley, Allison, Kostyk, Sandra K., Mitchell, Casey, Hellman, Amy, Houston, Sheryl, Buchanan, Danielle, McDonell, Katherine, Factor, Stewart A., Sperin, Elaine, Hurt, Andrea, Wojcieszek, Joanne, Adurogbangba, Mike, Raymond, Lynn A., Corey-Bloom, Jody, Snell, Chase, Blair, Courtney, Sung, Victor, Antonioli, Sophia, Fung, Jacqueline, Laganiere, Simon, Sierra, Luis, Mallonee, William M., Suter, Greg, Bega, Danny, Brown, Zsa Zsa, Elmer, Lawrence, Vollmar, Nancy, del Castillo, Debra, Lin, Yi-Han, Andrzejewski, Kelly, Weigel, Patricia, Hawkins, Trevor, Kirby, Kendra, Retzik-Stahr, Cimmaron, Seeberger, Lauren, Dhall, Rohit, Rassmann, Anja, Luxmore, McKenzie, Scott, Burton, Bulica, Bisena, Boyd, James, Chan, Katherine, McFarland, Nikolaus, Rizer, Kyle, Conlon, Patricia, Suski, Valerie, Rodriguez-Porcel, Federico, Wilson, Sandra, Farrell, Christine, Hunter, David, Houghton, David, Seoane, Sarah, Gibbons, Clare, Rizek, Philippe, Kuprewicz, Robin, Lo, Steven, Cuturic, Miroslav, Segro, Vicki, Greenly, Kate, Revilla, Fredy, Urrea-Mendoza, Enrique, Black, Kevin J., Davis, Thomas, Stover, Natividad, Duker, Andrew, Van Gerpen, Jay, Hedera, Peter, Ondo, William, Anderson, Karen, Bradley, Stephen, Cheung, Ken, Frank, Samuel, Furr Stimming, Erin, Claassen, Daniel O, Kayson, Elise, Goldstein, Jody, Mehanna, Raja, Zhang, Hui, Liang, Grace S, and Haubenberger, Dietrich

Published
2023
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4. Detecting Manifest Huntington's Disease Using Vocal Data

Author

Subramanian, Vinod, primary, Kwon, Namhee, additional, Brueckner, Raymond, additional, Blaylock, Nate, additional, O'Connell, Henry, additional, Sierra, Luis, additional, Ullman, Clementina, additional, Hildebrand, Karen, additional, and Laganiere, Simon, additional

Published
2023
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8. Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington's disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial

Author

Stimming, Erin Furr, primary, Claassen, Daniel O, additional, Kayson, Elise, additional, Goldstein, Jody, additional, Mehanna, Raja, additional, Zhang, Hui, additional, Liang, Grace S, additional, Haubenberger, Dietrich, additional, Adams, Jamie, additional, Beck, Christopher, additional, Chen, Cheryl, additional, Nance, Martha, additional, Testa, Claudia, additional, Huffman, Patricia, additional, Chesire, Amy, additional, Marshall, Frederick, additional, Dayalu, Praveen, additional, Stovall, Angela, additional, Hall, Deborah, additional, Hawkins, Jacob, additional, Ginsburg, Letty, additional, Moore, Henry, additional, Mestre, Tiago, additional, Thompson, Tanya, additional, Connors, Natalie, additional, Rosas, H. Diana, additional, Daley, Allison, additional, Kostyk, Sandra K., additional, Mitchell, Casey, additional, Hellman, Amy, additional, Houston, Sheryl, additional, Buchanan, Danielle, additional, McDonell, Katherine, additional, Factor, Stewart A., additional, Sperin, Elaine, additional, Hurt, Andrea, additional, Wojcieszek, Joanne, additional, Adurogbangba, Mike, additional, Raymond, Lynn A., additional, Corey-Bloom, Jody, additional, Snell, Chase, additional, Blair, Courtney, additional, Sung, Victor, additional, Antonioli, Sophia, additional, Fung, Jacqueline, additional, Laganiere, Simon, additional, Sierra, Luis, additional, Mallonee, William M., additional, Suter, Greg, additional, Bega, Danny, additional, Brown, Zsa Zsa, additional, Elmer, Lawrence, additional, Vollmar, Nancy, additional, del Castillo, Debra, additional, Lin, Yi-Han, additional, Andrzejewski, Kelly, additional, Weigel, Patricia, additional, Hawkins, Trevor, additional, Kirby, Kendra, additional, Retzik-Stahr, Cimmaron, additional, Seeberger, Lauren, additional, Dhall, Rohit, additional, Rassmann, Anja, additional, Luxmore, McKenzie, additional, Scott, Burton, additional, Boyd, James, additional, Chan, Katherine, additional, McFarland, Nikolaus, additional, Rizer, Kyle, additional, Conlon, Patricia, additional, Suski, Valerie, additional, Rodriguez-Porcel, Federico, additional, Wilson, Sandra, additional, Farrell, Christine, additional, Hunter, David, additional, Houghton, David, additional, Seoane, Sarah, additional, Gibbons, Clare, additional, Rizek, Philippe, additional, Kuprewicz, Robin, additional, Lo, Steven, additional, Cuturic, Miroslav, additional, Segro, Vicki, additional, Greenly, Kate, additional, Revilla, Fredy, additional, Urrea-Mendoza, Enrique, additional, Black, Kevin J., additional, Davis, Thomas, additional, Stover, Natividad, additional, Duker, Andrew, additional, Van Gerpen, Jay, additional, Hedera, Peter, additional, Ondo, William, additional, Anderson, Karen, additional, Bradley, Stephen, additional, Cheung, Ken, additional, and Frank, Samuel, additional

Published
2023
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17. Noninvasive Brain Stimulation in Pediatric Attention-Deficit Hyperactivity Disorder (ADHD): A Review

Author

Rubio, Belen, Boes, Aaron D, Laganiere, Simon, Rotenberg, Alexander, Jeurissen, Danique, Pascual-Leone, Alvaro, Rubio, Belen, Boes, Aaron D, Laganiere, Simon, Rotenberg, Alexander, Jeurissen, Danique, and Pascual-Leone, Alvaro

Abstract

Attention-deficit hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders in the pediatric population. The clinical management of ADHD is currently limited by a lack of reliable diagnostic biomarkers and inadequate therapy for a minority of patients who do not respond to standard pharmacotherapy. There is optimism that noninvasive brain stimulation may help to address these limitations. Transcranial magnetic stimulation and transcranial direct current stimulation are 2 methods of noninvasive brain stimulation that modulate cortical excitability and brain network activity. Transcranial magnetic stimulation can be used diagnostically to probe cortical neurophysiology, whereas daily use of repetitive transcranial magnetic stimulation or transcranial direct current stimulation can induce long-lasting and potentially therapeutic changes in targeted networks. In this review, we highlight research showing the potential diagnostic and therapeutic applications of transcranial magnetic stimulation and transcranial direct current stimulation in pediatric ADHD. We also discuss the safety and ethics of using these tools in the pediatric population.

Published
2016

22. Noninvasive Brain Stimulation in Pediatric Attention-Deficit Hyperactivity Disorder (ADHD).

Author

Rubio, Belen, Boes, Aaron D., Laganiere, Simon, Rotenberg, Alexander, Jeurissen, Danique, and Pascual-Leone, Alvaro

Subjects
TRANSCRANIAL magnetic stimulation, ATTENTION-deficit hyperactivity disorder, BIOMARKERS, DRUG therapy, NEUROPHYSIOLOGY
Abstract

Attention-deficit hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders in the pediatric population. The clinical management of ADHD is currently limited by a lack of reliable diagnostic biomarkers and inadequate therapy for a minority of patients who do not respond to standard pharmacotherapy. There is optimism that noninvasive brain stimulation may help to address these limitations. Transcranial magnetic stimulation and transcranial direct current stimulation are 2 methods of noninvasive brain stimulation that modulate cortical excitability and brain network activity. Transcranial magnetic stimulation can be used diagnostically to probe cortical neurophysiology, whereas daily use of repetitive transcranial magnetic stimulation or transcranial direct current stimulation can induce long-lasting and potentially therapeutic changes in targeted networks. In this review, we highlight research showing the potential diagnostic and therapeutic applications of transcranial magnetic stimulation and transcranial direct current stimulation in pediatric ADHD. We also discuss the safety and ethics of using these tools in the pediatric population. [ABSTRACT FROM AUTHOR]

Published
2016
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23. Transgenic expression of an expanded (GCG)13 repeat PABPN1 leads to weakness and coordination defects in mice

Author

Dion, Patrick, primary, Shanmugam, Vijayalakshmi, additional, Gaspar, Claudia, additional, Messaed, Christiane, additional, Meijer, Inge, additional, Toulouse, André, additional, Laganiere, Janet, additional, Roussel, Julie, additional, Rochefort, Daniel, additional, Laganiere, Simon, additional, Allen, Carol, additional, Karpati, George, additional, Bouchard, Jean-Pierre, additional, Brais, Bernard, additional, and Rouleau, Guy A., additional

Published
2005
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24. Transgenic expression of an expanded (GCG)13 repeat PABPN1 leads to weakness and coordination defects in mice

Author

Dion, Patrick, Shanmugam, Vijayalakshmi, Gaspar, Claudia, Messaed, Christiane, Meijer, Inge, Toulouse, André, Laganiere, Janet, Roussel, Julie, Rochefort, Daniel, Laganiere, Simon, Allen, Carol, Karpati, George, Bouchard, Jean-Pierre, Brais, Bernard, and Rouleau, Guy A.

Subjects
*MUSCULAR dystrophy, *NEUROMUSCULAR diseases, *NEURONS, *DYSTROPHY
Abstract

Abstract: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset disorder caused by a (GCG)n trinucleotide repeat expansion in the poly(A) binding protein nuclear-1 (PABPN1) gene, which in turn leads to an expanded polyalanine tract in the protein. We generated transgenic mice expressing either the wild type or the expanded form of human PABPN1, and transgenic animals with the expanded form showed clear signs of abnormal limb clasping, muscle weakness, coordination deficits, and peripheral nerves alterations. Analysis of mitotic and postmitotic tissues in those transgenic animals revealed ubiquitinated PABPN1-positive intranuclear inclusions (INIs) in neuronal cells. This latter observation led us to test and confirm the presence of similar INIs in postmortem brain sections from an OPMD patient. Our results indicate that expanded PABPN1, presumably via the toxic effects of its polyalanine tract, can lead to inclusion formation and neurodegeneration in both the mouse and the human. [Copyright &y& Elsevier]

Published
2005
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