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Texto completo: acesso restrito. p. 1491–1500 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-29T17:05:14Z No. of bitstreams: 1 1-s2.0-S0198885913004941-main.pdf: 1938576 bytes, checksum: d3439607edf50622cba711a087c1370a (MD5) Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-02T11:33:19Z (GMT) No. of bitstreams: 1 1-s2.0-S0198885913004941-main.pdf: 1938576 bytes, checksum: d3439607edf50622cba711a087c1370a (MD5) Made available in DSpace on 2014-06-02T11:33:19Z (GMT). No. of bitstreams: 1 1-s2.0-S0198885913004941-main.pdf: 1938576 bytes, checksum: d3439607edf50622cba711a087c1370a (MD5) Previous issue date: 2013 Th1 immune responses are crucial for eliminating Leishmania parasites. However, despite strong Th1 responses, cutaneous leishmaniasis (CL) patients infected with Leishmania braziliensis develop the disease, while milder Th1 responses are found in sub-clinical (SC) infections. Therefore, CL patients may experience impaired regulatory T cell (Treg) function, causing excessive Th1 responses and tissue damage. To address this hypothesis, we characterized the function of circulating Tregs in L. braziliensis infected CL patients and compared them to Tregs from uninfected controls (UC) and SC subjects. The frequency of circulating Tregs was similar in CL patients, UC and SC subjects. Moreover, CL patients Tregs suppressed lymphocyte proliferation and PBMC pro-inflammatory cytokine production more efficiently than UC Tregs, and also produced higher levels of IL-10 than UC and SC Tregs. Furthermore, PBMC and mononuclear cells from lesions of CL patients responded normally to Treg-induced suppression. Therefore, the lesion development in CL patients infected with L. braziliensis is not associated with impairment in Treg function or failure of cells to respond to immunomodulation. Rather, the increased Treg activation in CL patients may impair parasite elimination, resulting in establishment of chronic infection. Thus, immunological strategies that interfere with this response may improve leishmaniasis treatment.

Texto completo: acesso restrito. p. 426-433 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-20T13:58:07Z No. of bitstreams: 1 Lara Jirmanus.pdf: 907622 bytes, checksum: af986cef41e37feb682ddd8f68c4896d (MD5) Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-09-23T13:49:21Z (GMT) No. of bitstreams: 1 Lara Jirmanus.pdf: 907622 bytes, checksum: af986cef41e37feb682ddd8f68c4896d (MD5) Made available in DSpace on 2014-09-23T13:49:22Z (GMT). No. of bitstreams: 1 Lara Jirmanus.pdf: 907622 bytes, checksum: af986cef41e37feb682ddd8f68c4896d (MD5) Previous issue date: 2012 The Health Post of Corte de Pedra is located in a region endemic for American tegumentary leishmaniasis (ATL) in the Brazilian state of Bahia, and it treats 500–1,300 patients annually. To describe temporal changes in the epidemiology of ATL, we reviewed a random sample of 10% of patient charts (N = 1,209) from 1988 to 2008. There was a twofold increase in the number of cases over the 20-year period, with fluctuations in 10-year cycles. Patients were most frequently male, between the ages of 10 and 30 years, and engaged in agricultural labor; 4.3% of patients had mucosal disease, and 2.4% of patients had disseminated disease. Over the study period, the number of disseminated cases increased threefold, the proportion of cases in younger patients and agricultural workers decreased, and the proportion of patients residing in coastal areas increased. ATL is on the rise in Bahia, with a 10-year periodicity and evolving changes in epidemiology and manifestations of disease.

Texto completo: acesso restrito. p. 712-715 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-07T13:52:25Z No. of bitstreams: 1 Trans R Soc Trop Med Hyg-2009.pdf: 296235 bytes, checksum: ee554da6140b40ce94a19ba13fe296f9 (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-19T19:57:30Z (GMT) No. of bitstreams: 1 Trans R Soc Trop Med Hyg-2009.pdf: 296235 bytes, checksum: ee554da6140b40ce94a19ba13fe296f9 (MD5) Made available in DSpace on 2013-11-19T19:57:30Z (GMT). No. of bitstreams: 1 Trans R Soc Trop Med Hyg-2009.pdf: 296235 bytes, checksum: ee554da6140b40ce94a19ba13fe296f9 (MD5) Previous issue date: 2009 American tegumentary leishmaniasis (ATL) can occur in different forms, classically categorised as cutaneous leishmaniasis, mucosal leishmaniasis, diffuse cutaneous leishmaniasis and disseminated leishmaniasis. We analysed the presence of atypical manifestations (vegetative, verrucous, crusted and lupoid) among a cohort of patients presenting to the Health Post of Corte de Pedra, Bahia, Brazil. Among 1396 patients diagnosed with ATL in 2005–2006, 35 patients (2.5%) presented with atypical manifestations of the disease. Of these patients, 14 were pregnant women, 2 were co-infected with HIV and 19 had no co-morbidity or other apparent risk factors for the development of atypical ATL. The latter 19 patients were the focus of this study. They were predominantly adult males, frequently presenting with facial lesions [P < 0.001; odds ratio (OR) = 17.5, 95% CI 6.1–52.4] and had higher rates of treatment failure with antimonial therapy (P < 0.001; OR = 327, 95% CI 45–6668) compared with patients with classic ATL attending in the same period. Thirteen cases healed with amphotericin B, introduced after failure of three or more courses of antimony, suggesting that amphotericin B should be considered as the drug of choice for all patients diagnosed with atypical ATL.

Texto completo: acesso restrito. p. 478-482 Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-21T11:51:20Z No. of bitstreams: 1 10.1086-520017.pdf: 284401 bytes, checksum: a82c59fcd9d227388c9c10c70bb4f53d (MD5) Rejected by Flávia Ferreira (flaviaccf@yahoo.com.br), reason: Por favor faça a inclusão dos autores de todos autores do artigo. Grata, on 2014-01-28T12:59:33Z (GMT) Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-28T16:04:49Z No. of bitstreams: 1 10.1086-520017.pdf: 284401 bytes, checksum: a82c59fcd9d227388c9c10c70bb4f53d (MD5) Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-30T13:28:59Z (GMT) No. of bitstreams: 1 10.1086-520017.pdf: 284401 bytes, checksum: a82c59fcd9d227388c9c10c70bb4f53d (MD5) Made available in DSpace on 2014-01-30T13:28:59Z (GMT). No. of bitstreams: 1 10.1086-520017.pdf: 284401 bytes, checksum: a82c59fcd9d227388c9c10c70bb4f53d (MD5) Previous issue date: 2007 Cutaneous leishmaniasis affects millions of people worldwide. After observations of atypical lesions in pregnant women at the health centers of Corte de Pedra, Brazil, 9 years of records were reviewed, and 26 pregnant patients were identified. A retrospective case-control study revealed that lesions in pregnant women were much larger than those in nonpregnant patients in an age- and sex-matched group (mean area, 6.08 cm2 vs. 1.46 cm2; P = .008), and many lesions had an exophytic nature. Despite foregoing treatment until after delivery, response to pentavalent antimony therapy was favorable (rate of cure with 1 course of treatment, 85%). High rates of preterm births (10.5%) and stillbirths (10.5%) were reported. Cutaneous leishmaniasis during pregnancy produces distinct lesions and may have adverse fetal effects.