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We report the experimental characterization and finite element modeling of magnetic fluid hyperthermia (MFH) in tissue-like media using tetramethyl ammonium hydroxide coated superparamagnetic iron oxide magnetic nanoparticles (MNPs) of size ∼19.6 ± 1.2 nm, prepared using a co-precipitation technique. MFH properties are probed for the MNPs in ∼1 wt. % agar, resembling the tumor and surrounding normal tissues. The field-induced temperature rise (ΔT) is experimentally measured in real-time utilizing an infrared camera. A finite element model (FEM) is utilized to simulate the spatiotemporal variations in the thermal profiles, which are found to be in good agreement with the experimental data. FEM-based parametric studies reveal that the thermal conductivity of the medium is the most significant parameter influencing the thermal profiles. The spatiotemporal variations in the thermal profiles are numerically studied for seven different tissues, and the obtained results indicate the highest ΔT for the breast tissue in the tumor and the surrounding regions, which is due to the lowest volumetric specific heat and the highest thermal conductivity of the breast tissue, respectively. Numerical studies on the thermal profiles for sub-surface tumors with parametrically varying depths indicate a strong exponential correlation between the surface and tumor temperature, where the regression coefficients are found to be correlated with the thermo-physical properties of the tissues. The obtained findings are beneficial for developing a simplistic and easily deployable framework for a priori generation of the thermal profiles for various tissues during MFH, which is useful for appropriate planning and parameter selection for MFH-based therapy. [ABSTRACT FROM AUTHOR]

Optical detection of defects of varying widths in ferromagnetic steel components is carried out using polyacrylic acid stabilized magnetic nanoemulsions (MNEs). Magnetic field lines are leaked from the defect regions, due to permeability variation, when a defective ferromagnetic steel component is magnetized. Under the influence of such magnetic flux leakage (MFL), the MNE droplets exhibit orientational ordering, where the inter-droplet separation within the chains varies with the strength of the magnetic field. Exploiting this tunable optical grating phenomenon, wide area naked eye visualization of the surface opening and buried defects is carried out. The defect morphology is accurately estimated using a double thresholding-based image processing technique. The optical contrast varies non-monotonically with defect width for the surface opening defects, which is due to the formation of the surface dipoles on the defect edges. The surface dipoles are strongly coupled for lower defect width due to smaller spatial separation, which causes the MFL to be lower. With increasing defect width, the surface magnetic field lines are diffused leading to a lowering of the MFL. In between, for ∼2 mm wide defect, MFL is the highest and the generated optical contrast is found to be the strongest. The MFL profiles are numerically estimated using finite element modeling and experimentally verified using a Hall probe. The cross correlation between the generated optical contrast and MFL magnitudes clearly demonstrates the non-monotonic effect of defect width on the optical contrast of the MNE-based sensors for large area naked eye non-destructive defect detection in ferromagnetic materials. [ABSTRACT FROM AUTHOR]

The effects of pH, MNP concentration, and medium viscosity on the magnetic fluid hyperthermia (MFH) properties of chitosan-coated superparamagnetic Fe 3 O 4 nanoparticles (MNPs) are probed here. Due to the protonation of the amide groups, the MNPs are colloidally stable at lower pH (∼2), but form aggregates at higher pH (∼8). The increased aggregate size at higher pH causes the Brownian relaxation time ( τ B ) to increase, leading to a decrease in specific absorption rate (SAR). For colloidal conditions ensuring Brownian-dominated relaxation dynamics, an increase in MNP concentrations or medium viscosity is found to increase the τ B . SAR decreases with increasing MNP concentration, whereas it exhibits a non-monotonic variation with increasing medium viscosity. Dynamic hysteresis loop-based calculations are found to be in agreement with the experimental results. The findings provide a greater understanding of the variation of SAR with the colloidal properties and show the importance of relaxation dynamics on MFH efficiency, where variations in the frequency-relaxation time product across the relaxation plateau cause significant variations in SAR. Further, the in vitro cytotoxicity studies show good bio-compatibility of the chitosan-coated Fe 3 O 4 MNPs. Higher SAR at acidic pH for bio-medically acceptable field parameters makes the bio-compatible chitosan-coated Fe 3 O 4 MNPs suitable for MFH applications., (© 2024 IOP Publishing Ltd.)

Hypothesis: The presence of nanoparticles at oil-water interface influences the interaction forces between Pickering emulsions. When charged nanoparticles are at the oil-water interface of an electrostatically stabilized emulsion, in addition to the screened Coulombic interaction, electric dipolar force also influences the total inter-droplet force profiles. An in-depth understanding of the effects of such electric dipolar forces is essential for designing colloidally stable Pickering nanoemulsions for various applications., Experiments: Inter-droplet forces between γ-Al 2 O 3 nanoparticle stabilized oil-in-water nanoemulsion, containing superparamagnetic nanoparticles (magnetically polarizable) in the oil phase, are measured using the magnetic-chaining technique at different pH and salt concentrations. The role of mono-, di- and tri-valent salts on the inter-droplet force profiles are assessed., Findings: Force measurement studies reveal a lowering of inter-droplet spacing, within the linear chains, for higher salt concentrations due to an increased screening. Strong interfacial attachment of the charged nanoparticles results in the formation of an asymmetric charge cloud leading to an electric dipolar interaction. Incorporating the contributions of electric dipolar and screened Coulombic interactions, the theoretically estimated total repulsive force magnitudes are in good agreement with the experimental data. The obtained results offer better insights into the nature of colloidal force between charged particle stabilized nanoemulsions., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Thermoregulatory control of human body temperature is of paramount importance for normal bodily functions. Exposure of the upper and lower limbs to localized cold stress can cause cold-induced injuries and often lower limbs are more susceptible to damages from cold-induced injuries. In this study, we use infrared thermal imaging to probe localized cold stress induced cutaneous vasoconstriction of lower limbs in 33 healthy subjects. The cold stress is actuated by applying ice to the plantar surfaces of the lower limbs for 180 s and after removal of the cold stress, infrared thermography is utilized to non-invasively monitor the time-dependent variations in vein pixel temperatures on the dorsal surfaces of the stimulated and non-stimulated feet. It is observed that the vein pixel temperature of the stimulated foot showed a non-monotonic variation with time, consisting of an initial decrease and the presence of an inversion time, beyond which temperature is regained. The initial decrease in vein pixel temperature of the stimulated foot is attributed to the reduced blood flow caused by the cold stress induced severe vasoconstriction. Beyond the inversion time, the vein pixel temperature is found to increase due to rewarming of the surrounding skin. Experimental findings indicate that the inversion time linearly increased with the age of the subject, indicating a reduced thermoregulatory efficiency for the aged subjects. This study provides a thermal imaging-based insight into the skin temperature re-distribution during the early stages of blood perfusion in lower limbs, after an exposure to a localized acute cold stress. Statistical analyses reveal that subject height, weight, body-mass index and gender do not influence the inversion time significantly. The experimental findings are important towards rapid evaluation of personnel fitness for deployment in extreme cold environment, treatment of cold-induced injuries and probing of thermoregulatory impairments., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Hypothesis: Magnetic fluid hyperthermia has attracted considerable attention for cancer therapeutics. Magnetic nanoemulsions are potential candidates for multi-modal hyperthermia due to the possibility of volumetric loading with suitable chemo/photo-therapy agents. Often, the nanocarriers are stabilized using organic molecules that behave differently under varying pH and hence, an understanding of their interfacial behaviour is important for practical applications., Experiments: We probe the magnetic heating efficiency of poly acrylic acid (PAA) stabilized oil-in-water magnetic nanoemulsions, as a function of pH, where the conformational changes of the PAA molecules are studied using dynamic light scattering and inter-droplet force measurements., Findings: A ~50% enhanced heating efficiency is observed when solution pH is reduced from ~9 to 3, which is attributed to the coil-to-globule conformational changes of the PAA molecules. The increased ionization of the carboxylic acid groups, at higher pH, leads to reduced hydrophobicity that results in an increase in the interfacial thermal resistance causing a lower magneto-thermal heating efficiency at higher pH. The proposed interfacial heat transfer hypothesis is experimentally verified using thermal imaging, where a lower rate of heat transfer is obtained at higher pH. The observed enhanced hyperthermia efficiency at low pH is beneficial for designing efficient pH-responsive nano-carriers for multi-modal hyperthermia., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Abnormal body temperature is a natural indicator of illness. Infrared thermography (IRT) is a fast, passive, non-contact and non-invasive alternative to conventional clinical thermometers for monitoring body temperature. Besides, IRT can also map body surface temperature remotely. Last five decades witnessed a steady increase in the utility of thermal imaging cameras to obtain correlations between the thermal physiology and skin temperature. IRT has been successfully used in diagnosis of breast cancer, diabetes neuropathy and peripheral vascular disorders. It has also been used to detect problems associated with gynecology, kidney transplantation, dermatology, heart, neonatal physiology, fever screening and brain imaging. With the advent of modern infrared cameras, data acquisition and processing techniques, it is now possible to have real time high resolution thermographic images, which is likely to surge further research in this field. The present efforts are focused on automatic analysis of temperature distribution of regions of interest and their statistical analysis for detection of abnormalities. This critical review focuses on advances in the area of medical IRT. The basics of IRT, essential theoretical background, the procedures adopted for various measurements and applications of IRT in various medical fields are discussed in this review. Besides background information is provided for beginners for better understanding of the subject., (Copyright © 2012 Elsevier B.V. All rights reserved.)