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2,120 results on '"Lai, Chih-Cheng"'

2. Changing Incidence and Characteristics of Photokeratoconjunctivitis During the COVID-19 Pandemic

Author

Lin, Yu-Shiuan, Lai, Chih-Cheng, Liu, Yu-Chang, Kuo, Shu-Chun, and Su, Shih-Bin

Subjects
COVID-19, SARS-CoV-2, ultraviolet light, photokeratoconjunctivitis, germicidal lamp, welding
Abstract

Introduction: Photokeratoconjunctivitis (PKC) is primarily caused by welding. However, inappropriate use of germicidal lamps, which have been widely used following the COVID-19 outbreak, can also cause PKC. Our goal in this study was to investigate the incidence of and changes in the causes of PKC during the coronavirus 2019 (COVID-19) pandemic.Methods: We conducted a single-center, retrospective observational study. The health records of patients who visited the emergency department in a tertiary care hospital from January 1, 2018–December 31, 2021 and were diagnosed with PKC, were reviewed. We then conducted an analysis to compare the characteristics of PKC before and after COVID-19 began and the features of PKC caused by welding and germicidal lamps.Results: There were 160 PKC cases with a clear etiology before the COVID-19 pandemic and 147 cases during the COVID-19 pandemic. No significant differences in age and gender were detected between the two groups. The incidence of PKC induced by the use of germicidal lamps during the COVID-19 pandemic was significantly higher (10.2%) than the incidence before the pandemic (3.1%). The ratio of females to males in the germicidal lamp subgroup was significantly higher than the ratio in the welding subgroup. Limitations included incomplete information due to the retrospective nature of the study, underestimation of incidence, and possible recall bias.Conclusion: In the era of COVID-19, clinicians should be aware of the hazards of germicidal lamps. Although the COVID-19 pandemic seems to show signs of easing, new infectious diseases that require protective measures could still emerge in the future. Therefore, injuries related to germicidal lamps deserve more public health attention.

Published
2024

31. Malnutrition and the Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-Institutional Population-Based Propensity Score-Matched Analysis

Author

Lee, Cheng-Ya, primary, Liang, Yung-Chun, additional, Hsu, Wan-Hsuan, additional, Tsai, Ya-Wen, additional, Liu, Ting-Hui, additional, Huang, Po-Yu, additional, Chuang, Min-Hsiang, additional, Hung, Kuo-Chuan, additional, Lee, Mei-Chuan, additional, Yu, Tsung, additional, Lai, Chih-Cheng, additional, Weng, Tzu-Chieh, additional, and Wu, Jheng-Yan, additional

Published
2024
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41. The effect of recombinant zoster vaccine on patients with chronic obstructive pulmonary diseases: A multi‐institutional propensity score‐matched cohort study.

Author

Tsai, Ya‐Wen, Zhang, Bin, Wu, Jheng‐Yan, Hsu, Wan‐Hsuan, Liu, Ting‐Hui, Chuang, Min‐Hsiang, Huang, Po‐Yu, and Lai, Chih‐Cheng

Subjects
CHRONIC obstructive pulmonary disease, HERPES zoster vaccines, VACCINATION status, PROPENSITY score matching, HERPES zoster, CONFIDENCE intervals
Abstract

Although the recombinant zoster vaccine (RZV) has demonstrated efficacy in reducing the risk of herpes zoster (HZ) for individuals aged 50 years and older, its effectiveness in patients with chronic obstructive pulmonary disease (COPD) remains uncertain. This study was conducted to assess the effect of RZV on the risk of HZ in COPD patients. A multi‐institutional propensity score‐matched retrospective cohort study was conducted using the TriNetX Research network, including individuals aged 40 years or older with COPD from January 1, 2018, to December 31, 2022. Patients with a history of HZ or prior zoster vaccination were excluded. The primary outcome was HZ occurrence, with secondary outcomes including severe and nonsevere HZ. After propensity score matching, each 17 431 patients receiving RZV and unvaccinated patients were included. The vaccinated group had a significantly lower risk of HZ compared to the unvaccinated group (HR, 0.62; [95% confidence intervals] 95% CI, 0.51–0.75, p < 0.01). Similar risk reductions were observed for nonsevere HZ (HR, 0.61; 95% CI, 049–0.75, p < 0.01) and severe HZ (HR, 0.53; 95% CI, 0.38–0.73, p < 0.01). Further subgroup analyses demonstrated consistent risk reductions across age (50–59, 60–69, 70–79, and ≥80 years), sex, and comorbidities, except for individual aged 40–49 years. This study confirms the effectiveness of RZV in reducing HZ risk in patients with COPD aged 50 years and older, supporting its administration in this population. However, vaccination rates remain low, highlighting the need for improved vaccination strategies in this high‐risk group. Efforts to enhance vaccine uptake are warranted to reduce HZ morbidity. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Clinical effectiveness of nirmatrelvir plus ritonavir on the short‐ and long‐term outcome in high‐risk children with COVID‐19

Author

Wu, Jheng‐Yan, primary, Chen, Chia‐Chen, additional, Liu, Mei‐Yuan, additional, Hsu, Wan‐Hsuan, additional, Tsai, Ya‐Wen, additional, Liu, Ting‐Hui, additional, Pin‐Chien, Sung, additional, Huang, Po‐Yu, additional, Chuang, Min‐Hsiang, additional, Lee, Mei‐Chuan, additional, Hung, Kuo‐Chuan, additional, Yu, Tsung, additional, and Lai, Chih‐Cheng, additional

Published
2024
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