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15 results on '"Lai, Zheng-Quan"'

2. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

Author

Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., and Park, Kevin B.

Published
2015
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5. Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis

Author

Xu, Nan, additional, Wu, Xue, additional, Luo, Hui-Juan, additional, Xu, Fang-Fang, additional, Huang, Qiong-Hui, additional, Wu, Jia-Zhen, additional, Gan, Yu-Xuan, additional, Li, Min-Yao, additional, Lai, Zheng-Quan, additional, Lin, Hui-Ran, additional, Chen, Jian-Nan, additional, Su, Zi-Ren, additional, Ai, Wei-Peng, additional, and Liu, Yu-Hong, additional

Published
2020
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7. Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway

Author

Zhang, Zhen-Biao, primary, Luo, Dan-Dan, additional, Xie, Jian-Hui, additional, Xian, Yan-Fang, additional, Lai, Zheng-Quan, additional, Liu, Yu-Hong, additional, Liu, Wei-Hai, additional, Chen, Jian-Nan, additional, Lai, Xiao-Ping, additional, Lin, Zhi-Xiu, additional, and Su, Zi-Ren, additional

Published
2018
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14. Fingerprinting and simultaneous determination of alkaloids in Picrasma quassioidesfrom different locations by high performance liquid chromatography with photodiode array detection

Author

Liao, Hui‐Jun, Lai, Zheng‐Quan, Su, Ji‐Yan, Yi, Yu‐Yang, Li, Yu‐Cui, Lai, Xiao‐Ping, Su, Zi‐Ren, and Lin, Zhi‐Xiu

Abstract

A simple and sensitive method was developed and validated for profiling and simultaneous quantitation of seven alkaloids (6‐hydroxy‐β‐carboline‐1‐carboxylic acid, β‐carboline‐1‐carboxylic acid, β‐carboline‐1‐propanoic acid, 3‐methylcanthin‐5,6‐dione, 5‐hydroxy‐4‐methoxycanthin‐6‐one, 1‐methoxycarbony‐β‐carboline, and 4,5‐dimethoxycanthin‐6‐one) in Picrasma quassioidegrown in different locations by high‐performance liquid chromatography with photodiode array detection. The analysis was conducted on a Phenomenex Gemini C18column at 35°C with mobile phase of 25 mM aqueous ammonium acetate (pH4.0, adjusted by glacial acetate acid) and acetonitrile. A common fingerprint chromatograph under 254 nm consisting of 27 peaks was constructed for the evaluation of the similarities among 31 P. quassioidesamples. Samples from Guangdong and Guangxi Provinces were found to be within group linkage and showed significant difference from that of Jiangxi Province origin by using principal component analysis and hierarchical clustering analysis. In addition, the seven alkaloids were identified by electrospray ionization mass spectrometry and comparing with reference standards and literature data. All of them were determined simultaneously using the established HPLCmethod. This rapid and effective analytical method could be employed for quality assessment of P. quassioide, as well as pharmaceutical products containing this herbal material.

Published
2012
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15. Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

Author

Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., and Park, B. Kevin

Subjects
Chemical stress, Keap1, Toxicity, Physiology (medical), Brusatol, Hepatocyte, Free radicals, Cell defense, respiratory system, Biochemistry, digestive system, environment and public health, Nrf2
Abstract

The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules have been reported, very few chemical inhibitors of Nrf2 have been identified to date. The quassinoid brusatol has recently been shown to inhibit Nrf2 and ameliorate chemoresistance in vitro and in vivo. Here, we show that brusatol provokes a rapid and transient depletion of Nrf2 protein, through a posttranscriptional mechanism, in mouse Hepa-1c1c7 hepatoma cells. Importantly, brusatol also inhibits Nrf2 in freshly isolated primary human hepatocytes. In keeping with its ability to inhibit Nrf2 signaling, brusatol sensitizes Hepa-1c1c7 cells to chemical stress provoked by 2,4-dinitrochlorobenzene, iodoacetamide, and N-acetyl-p-benzoquinone imine, the hepatotoxic metabolite of acetaminophen. The inhibitory effect of brusatol toward Nrf2 is shown to be independent of its repressor Keap1, the proteasomal and autophagic protein degradation systems, and protein kinase signaling pathways that are known to modulate Nrf2 activity, implying the involvement of a novel means of Nrf2 regulation. These findings substantiate brusatol as a useful experimental tool for the inhibition of Nrf2 signaling and highlight the potential for therapeutic inhibition of Nrf2 to alter the risk of adverse events by reducing the capacity of nontarget cells to buffer against chemical and oxidative insults. These data will inform a rational assessment of the risk:benefit ratio of inhibiting Nrf2 in relevant therapeutic contexts, which is essential if compounds such as brusatol are to be developed into efficacious and safe drugs.

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