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30 results on '"Lai,Zefeng"'

2. Cognitive Diagnosis with Explicit Student Vector Estimation and Unsupervised Question Matrix Learning

Author

Dong, Lu, Ling, Zhenhua, Ling, Qiang, and Lai, Zefeng

Subjects
Computer Science - Computers and Society, Computer Science - Machine Learning, Computer Science - Social and Information Networks
Abstract

Cognitive diagnosis is an essential task in many educational applications. Many solutions have been designed in the literature. The deterministic input, noisy "and" gate (DINA) model is a classical cognitive diagnosis model and can provide interpretable cognitive parameters, e.g., student vectors. However, the assumption of the probabilistic part of DINA is too strong, because it assumes that the slip and guess rates of questions are student-independent. Besides, the question matrix (i.e., Q-matrix) recording the skill distribution of the questions in the cognitive diagnosis domain often requires precise labels given by domain experts. Thus, we propose an explicit student vector estimation (ESVE) method to estimate the student vectors of DINA with a local self-consistent test, which does not rely on any assumptions for the probabilistic part of DINA. Then, based on the estimated student vectors, the probabilistic part of DINA can be modified to a student dependent model that the slip and guess rates are related to student vectors. Furthermore, we propose an unsupervised method called heuristic bidirectional calibration algorithm (HBCA) to label the Q-matrix automatically, which connects the question difficulty relation and the answer results for initialization and uses the fault tolerance of ESVE-DINA for calibration. The experimental results on two real-world datasets show that ESVE-DINA outperforms the DINA model on accuracy and that the Q-matrix labeled automatically by HBCA can achieve performance comparable to that obtained with the manually labeled Q-matrix when using the same model structure., Comment: 9 pages, 6 figures

Published
2022

20. Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway [Corrigendum]

Author

Qin,Yue, Li,Suning, Zhao,Gan, Fu,Xuanhao, Xie,Xueping, Huang,Yiyi, Cheng,Xiaojing, Wei,Jinbin, Liu,Huagang, Lai,Zefeng, Qin,Yue, Li,Suning, Zhao,Gan, Fu,Xuanhao, Xie,Xueping, Huang,Yiyi, Cheng,Xiaojing, Wei,Jinbin, Liu,Huagang, and Lai,Zefeng

Abstract

Yue Qin, Suning Li, Gan Zhao, et al. Int J Nanomedicine. 2017;12:263–277.Page 266. In the right column the data range “6 to 15 nm” should be “5 to 15 nm”.Page 267. In Figure 1 Notes “wt%” should be “wt‰ in SWNTs powder”.Page 268. In Figure 2 Notes “1 mL per rat” should be “1 mL/kg body weight”.Read the original article.&nbsp

Published
2017

21. Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway [Corrigendum]

Author

Qin, Yue, primary, Li, Suning, additional, Zhao, Gan, additional, Fu, Xuanhao, additional, Xie, Xueping, additional, Huang, Yiyi, additional, Cheng, Xiaojing, additional, Wei, Jinbin, additional, Liu, Huagang, additional, and Lai, Zefeng, additional

Published
2017
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22. Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway

Author

Qin,Yue, Li,Suning, Zhao,Gan, Fu,Xuanhao, Xie,Xueping, Huang,Yiyi, Cheng,Xiaojing, Wei,Jinbin, Liu,Huagang, Lai,Zefeng, Qin,Yue, Li,Suning, Zhao,Gan, Fu,Xuanhao, Xie,Xueping, Huang,Yiyi, Cheng,Xiaojing, Wei,Jinbin, Liu,Huagang, and Lai,Zefeng

Abstract

Yue Qin,1,* Suning Li,2,* Gan Zhao,2,* Xuanhao Fu,1 Xueping Xie,1 Yiyi Huang,1 Xiaojing Cheng,3 Jinbin Wei,1 Huagang Liu,1 Zefeng Lai1 1Pharmaceutical College, Guangxi Medical University, 2Department of Pharmacy, The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, 3Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China *These authors contributed equally to this work Abstract: Numerous studies have demonstrated promising application of single-walled carbon nanotubes (SWNTs) in drug delivery, diagnosis, and targeted therapy. However, the adverse health effects resulting from intravenous injection of SWNTs are not completely understood. Studies have shown that levels of “pristine” or carboxylated carbon nanotubes are very high in mouse lungs after intravenous injection. We hypothesized that long-term and repeated intravenous administration of carboxylated SWNTs (c-SWNTs) can result in persistent accumulation and induce histopathologic changes in rat lungs. Here, c-SWNTs were administered repeatedly to rats via tail-vein injection for 90 days. Long-term intravenous injection of c-SWNTs caused sustained embolization in lung capillaries and granuloma formation. It also induced a persistent inflammatory response that was regulated by the nuclear factor-kappa B signaling pathway, and which resulted in pulmonary fibrogenesis. c-SWNTs trapped within lung capillaries traversed capillary walls and injured alveolar epithelial cells, thereby stimulating production of pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1 beta) and pro-fibrotic growth factors (transforming growth factor-beta 1). Protein levels of type-I and type-III collagens, matrix metalloproteinase-2, and the tissue inhibitor of metalloproteinase-2 were upregulated after intravenous exposure to c-SWNTs as determined by immunohistochemical assays and Western blotting, which suggested collagen depos

Published
2016

27. Synthesis, structure and antiproliferative activity of organometallic iridium(III) complexes containing thiosemicarbazone ligands.

Author

Su, Wei, Peng, Binghua, Li, Peiyuan, Xiao, Qi, Huang, Shan, Gu, Yunqiong, and Lai, Zefeng

Subjects
METAL complexes, IRIDIUM compounds, ORGANOMETALLIC compounds, THIOSEMICARBAZONES, LIGANDS (Chemistry), MOLECULAR structure
Abstract

A series of half-sandwich iridium complexes ( 1- 4) with thiosemicarbazone ligands in two types of coordination modes were synthesized and characterized. The molecular structures of compounds 1, 2 and 3 were determined using single-crystal X-ray diffraction analysis. The nature of the complexes was studied using density functional theory calculations. The stability of the complexes was investigated using UV-visible absorption spectroscopy. The compounds were further evaluated for their in vitro antiproliferative activities against HeLa, HepG2, CNE-2, SGC-7901, KB and HEK-293 T cell lines. Compound 2 displays the highest antiproliferative activity among the other analogues and cisplatin. [ABSTRACT FROM AUTHOR]

Published
2017
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30. Effects of Averrhoa carambola L. (Oxalidaceae) juice mediated on hyperglycemia, hyperlipidemia, and its influence on regulatory protein expression in the injured kidneys of streptozotocin-induced diabetic mice.

Author

Pham HT, Huang W, Han C, Li J, Xie Q, Wei J, Xu X, Lai Z, Huang X, Huang R, and Wen Q

Abstract

Recently, many reports have shown that Averrhoa carambola L. (Oxalidaceae) juice (EACJ) could reduce blood glucose in humans. However, its mechanisms have not been well explored; therefore, our study aimed to investigate the beneficial effects of EACJ on hyperglycemia, hyperlipidemia and renal injury in streptozotocin (STZ)-induced diabetic mice. Those mice were injected with STZ via the tail vein (120 mg/kg body weight) and were identified as diabetic mice when the level of blood glucose was ≥ 11.1 mmol/L. Those mice were intragastriced gavage with saline, EACJ (25, 50, 100 g/kg body weight/d) and metformin (320 mg/kg body weight/d) for 21 days. The fasting blood glucose (FBG), free fatty acids (FFA), total cholesterol (TC), triglycerides (TG), Scr (CREA) and blood urea nitrogen (BUN) were significantly decreased, while the sorbitol dehydrogenase (SDH), Cyclic Adenosine monophosphate (cAMP), malondialdehyde (MDA), superoxide dismutase (SOD), and insulin were elevated. Diabetes-dependent alterations in the kidney, such as glomerular hypertrophy, thicken and tubular basement membrane, were improved after 21 days of EACJ treatment. Hyperglycemia, renal formation and the expressions of related proteins such as connective tissue growth factor (CTGF) and transforming growth factor beta 1 (TGF-β1) were markedly decreased by EACJ. These results indicate that EACJ treatment decrease hyperglycemia, hyperlipidemia and inhibit the progression of diabetic nephropathy (DN), which may be linked to regulating several pharmacological targets for treating or preventing DN.

Published
2017

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