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Current socket casting methods used in under-resourced environments are highly reliant on the skill and experience of the prosthetist. Pressure-casting methods have been advocated to reduce skill dependency in socket casting. To date, however, socket production studies have only been performed in resourced settings and involved qualified prosthetists. In this thesis, a pressure-casting method to reduce the skill dependency in socket casting has been described in detail. Appropriate and feasible measures to assess wearer outcomes comprised standard functional tests, spatio-temporal gait parameters, subjective measures of user satisfaction and quantification of the limb-socket interface pressures. The participants of all studies herein were adults with unilateral transtibial amputations. All studies were conducted in Vietnam and utilised pressure-cast (PCAST) sockets with low-cost polypropylene components. All sockets were cast by local orthopaedic technicians when appropriate. Wearer outcomes with the PCAST sockets were similar to the participants’ original prosthetic limbs and high levels of satisfaction were recorded following an extended usage period of five months. Temporal gait changes suggested greater willingness to load the prosthetic limb over the usage period. In contrast, satisfaction and comfort data suggested that feelings of comfort and stability decreased over the usage period. As a baseline, the participants’ original prostheses were not consistent due to varying age, quality and socket design. Thus, the outcomes of participants fit with both PCAST and PTB sockets were compared. The results showed no significant differences in the initial participant functionality, spatio-temporal gait characteristics, gait symmetry, or comfort between the skill-dependent PTB socket and the PCAST socket. PCAST socket fit was investigated by examining interface pressure distribution, magnitude and duration and exploring how these pressures vary with wearer comfort. The