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4. Kappa Free Light Chain Biomarkers Are Efficient for the Diagnosis of Multiple Sclerosis: A Large Multicenter Cohort Study

Author

Levraut, Michael, Laurent-Chabalier, Sabine, Ayrignac, Xavier, Bigaut, Kévin, Rival, Manon, Squalli, Sanae, Zéphir, Hélène, Alberto, Tifanie, Pekar, Jean-David, Ciron, Jonathan, Biotti, Damien, Puissant-Lubrano, Bénédicte, Camdessanché, Jean-Philippe, Tholance, Yannick, Casez, Olivier, Toussaint, Bertrand, Marion, Jeanne, Moreau, Thibault, Lakomy, Daniela, Thomasset, Audrey, Maillart, Elisabeth, Sterlin, Delphine, Maurousset, Aude, Rocher, Auriane, Laplaud, David Axel, Bigot-Corbel, Edith, Bertho, Pierre-Olivier, Pelletier, Jean, Boucraut, Joseph, Labauge, Pierre, Vincent, Thierry, De Sèze, Jérôme, Jahn, Isabelle, Seitz-Polski, Barbara, Thouvenot, Eric, and Lebrun-Frenay, Christine

Published
2023
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6. Early Chimeric Antigen Receptor T Cell Expansion Is Associated with Prolonged Progression-Free Survival for Patients with Relapsed/Refractory Multiple Myeloma Treated with Ide-Cel: A Retrospective Monocentric Study

Author

Caillot, Leo, Sleiman, Emmanuel, Lafon, Ingrid, Chretien, Marie-Lorraine, Gueneau, Pauline, Payssot, Alexandre, Pedri, Romain, Lakomy, Daniela, Bailly, François, Guy, Julien, Quenot, Jean-Pierre, Avet-Loiseau, Herve, and Caillot, Denis

Abstract

•Ide-cel is an effective and safe therapy for progressive and relapsed/refractory multiple myeloma.•The median progression-free survival (PFS) was 14.8 months after ide-cel infusion.•The level of CAR-T cell expansion is associated with prolonged PFS.•Patients with high BCMA levels before ide-cel therapy had a poor prognosis.

Published
2024
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9. Clinical association of mixed connective tissue disease and granulomatosis with polyangiitis: a case report and systematic screening of anti-U1RNP and anti-PR3 auto-antibody double positivity in ten European hospitals

Author

Tubery, Amandine, Fortenfant, Françoise, Combe, Bernard, Abreu, Isabelle, Bossuyt, Xavier, Chretien, Pascale, Desplat-Jégo, Sophie, Fabien, Nicole, Hue, Sophie, Johanet, Catherine, Lakomy, Daniela, Vincent, Thierry, and Daïen, Claire I.

Published
2016
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10. Heterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study

Author

Picard, Cécile, Vincent, Thierry, Lega, Jean-Christophe, Hue, Sophie, Fortenfant, Françoise, Lakomy, Daniela, Humbel, René-Louis, Goetz, Joelle, Molinari, Nicolas, Bardin, Nathalie, Bertin, Daniel, Johanet, Catherine, Chretien, Pascale, Dubucquoi, Sylvain, Streichenberger, Nathalie, Desplat-Jégo, Sophie, Bossuyt, Xavier, Sibilia, Jean, Abreu, Isabelle, Chevailler, Alain, and Fabien, Nicole

Published
2016
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14. Kappa Free Light Chains Intrathecal Synthesis Biomarkers are Efficient Tools for the Diagnosis of Multiple Sclerosis: a Large Multicenter Cohort Study (S19.003)

Author

Levraut, Michael, primary, Ayrignac, Xavier, additional, Bigaut, Kevin, additional, Chabalier, Sabine, additional, Rival, Manon, additional, Agherbi, Hanane, additional, Squalli, Sanae, additional, Zephir, Helene, additional, Alberto, Tifanie, additional, Pekar, Jean David, additional, Ciron, Jonathan, additional, Freitas, Noellie, additional, Biotti, Damien, additional, Camdessanche, Jean-Phillippe, additional, Tholance, Yannick, additional, Visneux, Vincent, additional, Casez, Olivier, additional, Toussaint, Bertrand, additional, Marion, Jeanne, additional, Le Gouellec, Audrey, additional, Moreau, Thibault, additional, Lakomy, Daniela, additional, Thomasset, Audrey, additional, Maillart, Elisabeth, additional, Sterlin, Delphine, additional, Maurousset, Aude, additional, Rocher, Auriane, additional, Cohen, Mikael, additional, Delourme, Adrien, additional, Bresch, Saskia, additional, Laplaud, David, additional, Bigot-Corbel, Edith, additional, Pelletier, Jean, additional, Boucraut, Jose, additional, Labauge, Pierre, additional, Huby, Sophie, additional, Vincent, Thierry, additional, De Seze, Jerome, additional, Jahn, Isabelle, additional, Seitz-Polski, Barbara, additional, Thouvenot, Eric, additional, and Lebrun-Frenay, Christine, additional

Published
2022
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21. Th1 and Th17 lymphocytes expressing CD161 are implicated in giant cell arteritis and polymyalgia rheumatica pathogenesis

Author

Samson, Maxime, Audia, Sylvain, Fraszczak, Jennifer, Trad, Malika, Ornetti, Paul, Lakomy, Daniela, Ciudad, Marion, Leguy, Vanessa, Berthier, Sabine, Vinit, Julien, Manckoundia, Patrick, Maillefert, Jean-Francis, Besancenot, Jean-François, Aho-Glele, Serge, Olsson, Nils Olivier, Lorcerie, Bernard, Guillevin, Loïc, Mouthon, Luc, Saas, Philippe, Bateman, Andrew, Martin, Laurent, Janikashvili, Nona, Larmonier, Nicolas, and Bonnotte, Bernard

Published
2012
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23. Venous thromboembolic events during warm autoimmune hemolytic anemia

Author

Audia, Sylvain, primary, Bach, Benoit, additional, Samson, Maxime, additional, Lakomy, Daniela, additional, Bour, Jean-Baptiste, additional, Burlet, Bénédicte, additional, Guy, Julien, additional, Duvillard, Laurence, additional, Branger, Marine, additional, Leguy-Seguin, Vanessa, additional, Berthier, Sabine, additional, Michel, Marc, additional, and Bonnotte, Bernard, additional

Published
2018
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25. Recommandations de l’IFM (Intergroupe francophone du myélome) pour l’harmonisation de l’analyse des électrophorèses des protéines sériques et urinaires dans le diagnostic et le suivi du myélome multiple [IFM (Intergroupe francophone du myelome) recommendations for uniform interpretation of serum and urine protein electrophoresis in multiple myeloma diagnosis and follow-up]

Author

Dejoie, Thomas, Lakomy, Daniela, Caillon, Hélène, Pegourie, Brigitte, Decaux, Olivier, Laboratoire de Biochimie [Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
free light-chain, [SDV.GEN]Life Sciences [q-bio]/Genetics, criteria
Abstract

National audience; Serum and urine proteins electrophoresis take a major place in multiple myeloma management, at time of diagnosis, during follow-up for treatment response evaluation and also in detection of relapse. The Intergroupe francophone du myelome (IFM) suggests recommendations to clinicians and biologists, to perform and interpret these biochemical analysis, with the objective of harmonizing practices between laboratories and improving patients' follow-up.

Published
2016
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28. Modulation of dendritic cells and macrophages : implication in cancer and atherosclerosis

Author

Lakomy, Daniela, Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Université de Bourgogne, Bernard Bonnotte, Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), and STAR, ABES

Subjects
Athérosclérose, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Cellules dendritiques, Macrophages, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Dentritic cells, lipids (amino acids, peptides, and proteins), Atherosclerosis, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cancer
Abstract

During my thesis, I studied the cytotoxic function of dendritic cells (DC) from cancer patients and compared it to DC from healthy donors. Our results indicate that human monocyte-derived DC can acquire strong cytotoxic activity toward tumor cells after activation with low dose of LPS. The cytotoxic potential of DC derived from cancer patients was almost the same as the one generated from healthy donors. We identified the tumor cell killing mechanism which involves peroxynitrite release. After killing of cancer cells, DC are capable of engulfing dead tumor cell fragments and overexpress the costimulatory molecules necessary for T cell proliferation. A second study consisted in an analysis of inflammatory macrophages and their significance in atherosclerosis. Macrophages produce CETP (cholesteryl ester transfert protein), a target for LXR (liver X receptor) receptors. Our results show that LXR-mediated induction of CETP expression is lost in inflammatory macrophages. Our study suggests that inflammatory macrophages may not increase the circulating CETP pool on LXR agonist treatment., Au cours de ma thèse, j’ai étudié la fonction cytotoxique des cellules dendritiques (DC) de patients cancéreux comparée à celle de sujets sains. Nous avons montré que les DC générées à partir des monocytes du sang périphérique peuvent acquérir des capacités cytotoxiques importantes après activation par des faibles doses de LPS. Le potentiel cytotoxique des DC générées à partir de patients cancéreux est comparable à celui de sujets sains. Nous avons identifié le mécanisme de cytotoxicité qui fait intervenir la production de peroxynitrite. Après avoir tué les cellules tumorales, les DC phagocytent des fragments tumoraux, surexpriment des molécules de costimulation et induisent la prolifération des lymphocytes. Un deuxième axe de recherche au cours de ma thèse a consisté en l’étude des macrophages inflammatoires et de leur implication dans l’athérosclérose. Les macrophages sécrètent la CETP (cholesteryl ester transfert protein), protéine-cible des récepteurs LXR (liver X receptor). Nous avons montré que l’expression de la CETP, en réponse aux agonistes LXR, n’est pas augmentée dans les macrophages inflammatoires. Ceci suggère que les macrophages inflammatoires ne participeraient pas à l’augmentation du pool plasmatique de CETP en cas de traitement par des agonistes LXR.

Published
2010

30. Recommandations de l'Intergroupe francophone du myéiome pour l'harmonisation de l'analyse des électrophoréses des protéines seriques et urinaires dans le diagnostic et le suivi du myélome multiple.

Author

Dejoie, Thomas, Lakomy, Daniela, Caillon, Hélène, Pegourié, Brigitte, and Decaux, Olivier

Abstract

Serum and urine proteins electrophoresis take a major place in multiple myeloma management, at time of diagnosis, during follow-up for treatment response evaluation and also in detection of relapse. The Intergroupe francophone du myelome (IFM) suggests recommendations to clinicians and biologists, to perform and interpret these biochemical analysis, with the objective of harmonizing practices between laboratories and improving patients' follow-up. [ABSTRACT FROM AUTHOR]

Published
2017
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33. Are Immunoglobulin A Anti-gliadin Antibodies Helpful in Diagnosing Coeliac Disease in Children Younger Than 2 Years?

Author

Foucher, Barbara, primary, Johanet, Catherine, additional, Jégo-Desplat, Sophie, additional, Sanmarco, Marielle, additional, Dubucquoi, Sylvain, additional, Fily-Nalewajk, Sandrine, additional, Olsson, Nils-Olivier, additional, Lakomy, Daniela, additional, Escande, Andrée, additional, Chrétien, Pascale, additional, Fortenfant, Françoise, additional, Chevailler, Alain, additional, André, Chantal, additional, Goetz, Joëlle, additional, Humbel, René-Louis, additional, Monier, Jean-Claude, additional, Sibilia, Jean, additional, Taillefer, Marie-France, additional, Abreu, Isabelle, additional, and Fabien, Nicole, additional

Published
2012
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34. Cytotoxic Dendritic Cells Generated from Cancer Patients

Author

Lakomy, Daniela, primary, Janikashvili, Nona, additional, Fraszczak, Jennifer, additional, Trad, Malika, additional, Audia, Sylvain, additional, Samson, Maxime, additional, Ciudad, Marion, additional, Vinit, Julien, additional, Vergely, Catherine, additional, Caillot, Denis, additional, Foucher, Pascal, additional, Lagrost, Laurent, additional, Chouaib, Salem, additional, Katsanis, Emmanuel, additional, Larmonier, Nicolas, additional, and Bonnotte, Bernard, additional

Published
2011
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35. Peroxynitrite-Dependent Killing of Cancer Cells and Presentation of Released Tumor Antigens by Activated Dendritic Cells

Author

Fraszczak, Jennifer, primary, Trad, Malika, additional, Janikashvili, Nona, additional, Cathelin, Dominique, additional, Lakomy, Daniela, additional, Granci, Virginie, additional, Morizot, Alexandre, additional, Audia, Sylvain, additional, Micheau, Olivier, additional, Lagrost, Laurent, additional, Katsanis, Emmanuel, additional, Solary, Eric, additional, Larmonier, Nicolas, additional, and Bonnotte, Bernard, additional

Published
2010
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36. Liver X Receptor–Mediated Induction of Cholesteryl Ester Transfer Protein Expression Is Selectively Impaired in Inflammatory Macrophages

Author

Lakomy, Daniela, primary, Rébé, Cédric, additional, Sberna, Anne-Laure, additional, Masson, David, additional, Gautier, Thomas, additional, Chevriaux, Angélique, additional, Raveneau, Magalie, additional, Ogier, Nicolas, additional, Nguyen, Anh Thoai, additional, Gambert, Philippe, additional, Grober, Jacques, additional, Bonnotte, Bernard, additional, Solary, Eric, additional, and Lagrost, Laurent, additional

Published
2009
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37. Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages

Author

Rébé, Cédric, primary, Raveneau, Magalie, additional, Chevriaux, Angélique, additional, Lakomy, Daniela, additional, Sberna, Anne-Laure, additional, Costa, Annie, additional, Bessède, Ginette, additional, Athias, Anne, additional, Steinmetz, Eric, additional, Lobaccaro, Jean Marc A., additional, Alves, Georges, additional, Menicacci, Alexandre, additional, Vachenc, Sébastien, additional, Solary, Eric, additional, Gambert, Philippe, additional, and Masson, David, additional

Published
2009
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39. Kappa Free Light Chain Biomarkers Are Efficient for the Diagnosis of Multiple Sclerosis: A Large Multicenter Cohort Study.

Author

Levraut M, Laurent-Chabalier S, Ayrignac X, Bigaut K, Rival M, Squalli S, Zéphir H, Alberto T, Pekar JD, Ciron J, Biotti D, Puissant-Lubrano B, Camdessanché JP, Tholance Y, Casez O, Toussaint B, Marion J, Moreau T, Lakomy D, Thomasset A, Maillart E, Sterlin D, Maurousset A, Rocher A, Laplaud DA, Bigot-Corbel E, Bertho PO, Pelletier J, Boucraut J, Labauge P, Vincent T, De Sèze J, Jahn I, Seitz-Polski B, Thouvenot E, and Lebrun-Frenay C

Subjects
Female, Humans, Immunoglobulin kappa-Chains, Oligoclonal Bands, Biomarkers, Cohort Studies, Multiple Sclerosis, Demyelinating Diseases diagnosis, Central Nervous System Diseases
Abstract

Background and Objectives: Kappa free light chains (KFLC) seem to efficiently diagnose MS. However, extensive cohort studies are lacking to establish consensus cut-offs, notably to rule out non-MS autoimmune CNS disorders. Our objectives were to (1) determine diagnostic performances of CSF KFLC, KFLC index, and KFLC intrathecal fraction (IF) threshold values that allow us to separate MS from different CNS disorder control populations and compare them with oligoclonal bands' (OCB) performances and (2) to identify independent factors associated with KFLC quantification in MS., Methods: We conducted a retrospective multicenter study involving 13 French MS centers. Patients were included if they had a noninfectious and nontumoral CNS disorder, eligible data concerning CSF and serum KFLC, albumin, and OCB. Patients were classified into 4 groups according to their diagnosis: MS, clinically isolated syndrome (CIS), other inflammatory CNS disorders (OIND), and noninflammatory CNS disorder controls (NINDC)., Results: One thousand six hundred twenty-one patients were analyzed (675 MS, 90 CIS, 297 OIND, and 559 NINDC). KFLC index and KFLC IF had similar performances in diagnosing MS from nonselected controls and OIND ( p = 0.123 and p = 0.991 for area under the curve [AUC] comparisons) and performed better than CSF KFLC ( p < 0.001 for all AUC comparisons). A KFLC index of 8.92 best separated MS/CIS from the entire nonselected control population, with better performances than OCB ( p < 0.001 for AUC comparison). A KFLC index of 11.56 best separated MS from OIND, with similar performances than OCB ( p = 0.065). In the multivariate analysis model, female gender ( p = 0.003), young age ( p = 0.013), and evidence of disease activity ( p < 0.001) were independent factors associated with high KFLC index values in patients with MS, whereas MS phenotype, immune-modifying treatment use at sampling, and the FLC analyzer type did not influence KFLC index., Discussion: KFLC biomarkers are efficient tools to separate patients with MS from controls, even when compared with other patients with CNS autoimmune disorder. Given these results, we suggest using KFLC index or KFLC IF as a criterion to diagnose MS., Classification of Evidence: This study provides Class III evidence that KFLC index or IF can be used to differentiate patients with MS from nonselected controls and from patients with other autoimmune CNS disorders., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)

Published
2022
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40. Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages.

Author

Rébé C, Raveneau M, Chevriaux A, Lakomy D, Sberna AL, Costa A, Bessède G, Athias A, Steinmetz E, Lobaccaro JM, Alves G, Menicacci A, Vachenc S, Solary E, Gambert P, and Masson D

Subjects
Apoptosis, Atherosclerosis enzymology, Cell Line, DNA-Binding Proteins metabolism, Enzyme Induction, Humans, Liver X Receptors, Orphan Nuclear Receptors, Protein Glutamine gamma Glutamyltransferase 2, Receptors, Cytoplasmic and Nuclear metabolism, Receptors, Retinoic Acid metabolism, Retinoic Acid Receptor alpha, DNA-Binding Proteins agonists, GTP-Binding Proteins biosynthesis, Macrophage Activation, Macrophages enzymology, Phagocytosis, Receptors, Cytoplasmic and Nuclear agonists, Receptors, Retinoic Acid agonists, Transglutaminases biosynthesis
Abstract

Rationale: Liver X receptors (LXRs) are oxysterol-activated nuclear receptors that are involved in the control of cholesterol homeostasis and inflammatory response. Human monocytes and macrophages express high levels of these receptors and are appropriate cells to study the response to LXR agonists., Objective: The purpose of this study was to identify new LXR targets in human primary monocytes and macrophages and the consequences of their activation., Methods and Results: We show that LXR agonists significantly increase the mRNA and protein levels of the retinoic acid receptor (RAR)alpha in primary monocytes and macrophages. LXR agonists promote RARalpha gene transcription through binding to a specific LXR response element on RARalpha gene promoter. Preincubation of monocytes or macrophages with LXR agonists before RARalpha agonist treatment enhances synergistically the expression of several RARalpha target genes. One of these genes encodes transglutaminase (TGM)2, a key factor required for macrophage phagocytosis. Accordingly, the combination of LXR and RARalpha agonists at concentrations found in human atherosclerotic plaques markedly enhances the capabilities of macrophages to engulf apoptotic cells in a TGM2-dependent manner., Conclusions: These results indicate an important role for LXRs in the control of phagocytosis through an RARalpha-TGM2-dependent mechanism. A combination of LXR/RARalpha agonists that may operate in atherosclerosis could also constitute a promising strategy to improve the clearance of apoptotic cells by macrophages in other pathological situations.

Published
2009
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