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7. Probable chromosomal mutation to resistance to all aminoglycosides in Staphylococcus aureus selected by the therapeutic use of gentamicin: a preliminary report.

Author

Heritage, John, Settle, John A. D., Lalani, El-Nasir M. A., and Lacey, Richard W.

Abstract

A patient suffering from burns was treated with gentamicin: subsequently, a ‘methicillin-resistant’ strain of (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive ‘methicillin-resistant’ prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates. [ABSTRACT FROM PUBLISHER]

Published
1986

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