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5. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, Gratz, Pascal, Mattle, Heinrich, Panos, Leonidas, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shaloo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Van Dam-Nolen, Dianne, Kooi, M Eline, Van der Lugt, Aad, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Best, Jonathan G, Ambler, Gareth, Wilson, Duncan, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sanchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Ben Assayag, Einor, Hallevi, Hen, Molad, Jeremy, Nishihara, Masashi, Tanaka, Jun, Coutts, Shelagh B, Polymeris, Alexandros, Wagner, Benjamin, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, L Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Fischer, Urs, El-Koussy, Marwan, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Mess, Werner H, Nederkoorn, Paul J, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Anne Cristine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, Hendrikse, Jeroen, Kelly, Peter J, Wardlaw, Joanna, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Hara, Hideo, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2021
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7. High burden of cerebral white matter lesion in 9 Asian cities

Author

Lam, Bonnie Yin Ka, Yiu, Brian, Ampil, Encarnita, Chen, Christopher Li-Hsian, Dikot, Yustiani, Dominguez, Jacqueline C., Ganeshbhai, Patel Vishal, Hilal, Saima, Kandiah, Nagaendran, Kim, SangYun, Lee, Jun-Young, Ong, Anam Paulus, Senanarong, Vorapun, Leung, Kam Tat, Wang, Huali, Yang, Yuan-Han, Yong, Tingting, Arshad, Faheem, Alladi, Suvarna, Wong, Samuel, Ko, Ho, Lau, Alexander Yuk Lun, and Mok, Vincent Chung Tong

Published
2021
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9. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, El-Koussy, Marwan, Gratz, Pascal, Molad, Jeremy, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shahoo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos;, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Nishihara, Masashi, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Hendrikse, Jeroen, Nederkoorn, Paul, Mess, Werner, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Wilson, Duncan, Ambler, Gareth, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sánchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Schrooten, Maarten, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Assayag, Einor Ben, Hallevi, Hen, Tanaka, Jun, Hara, Hideo, Coutts, Shelagh B, Hert, Lisa, Polymeris, Alexandros, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Mattle, Heinrich P, Panos, Leonidas D, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Kooi, M Eline, van Dam-Nolen, Dianne H K, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Christine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, van der Lugt, Aad, Kelly, Peter J, Wardlaw, Joanna M, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2019
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13. The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis

Author

Lam, Bonnie Yin Ka, primary, Cai, Yuan, additional, Akinyemi, Rufus, additional, Biessels, Geert Jan, additional, van den Brink, Hilde, additional, Chen, Christopher, additional, Cheung, Chin Wai, additional, Chow, King Ngai, additional, Chung, Henry Kwun Hang, additional, Duering, Marco, additional, Fu, Siu Ting, additional, Gustafson, Deborah, additional, Hilal, Saima, additional, Hui, Vincent Ming Ho, additional, Kalaria, Rajesh, additional, Kim, SangYun, additional, Lam, Maggie Li Man, additional, de Leeuw, Frank Erik, additional, Li, Ami Sin Man, additional, Markus, Hugh Stephen, additional, Marseglia, Anna, additional, Zheng, Huijing, additional, O’Brien, John, additional, Pantoni, Leonardo, additional, Sachdev, Perminder Singh, additional, Smith, Eric E, additional, Wardlaw, Joanna, additional, and Mok, Vincent Chung Tong, additional

Published
2022
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14. Improved sensitivity and precision in multicentre diffusion MRI network analysis using thresholding and harmonization

Author

Projectafdeling VCI, Beeldverwerking ISI, Cancer, MS Geriatrie, Circulatory Health, Brain, Opleiding Neurologie, Neurologen, de Brito Robalo, Bruno M, de Luca, Alberto, Chen, Christopher, Dewenter, Anna, Duering, Marco, Hilal, Saima, Koek, Huiberdina L, Kopczak, Anna, Lam, Bonnie Yin Ka, Leemans, Alexander, Mok, Vincent, Onkenhout, Laurien P, van den Brink, Hilde, Biessels, Geert Jan, Projectafdeling VCI, Beeldverwerking ISI, Cancer, MS Geriatrie, Circulatory Health, Brain, Opleiding Neurologie, Neurologen, de Brito Robalo, Bruno M, de Luca, Alberto, Chen, Christopher, Dewenter, Anna, Duering, Marco, Hilal, Saima, Koek, Huiberdina L, Kopczak, Anna, Lam, Bonnie Yin Ka, Leemans, Alexander, Mok, Vincent, Onkenhout, Laurien P, van den Brink, Hilde, and Biessels, Geert Jan

Published
2022

15. sj-docx-1-wso-10.1177_17474930221137019 – Supplemental material for The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis

Author

Lam, Bonnie Yin Ka, Cai, Yuan, Akinyemi, Rufus, Biessels, Geert Jan, van den Brink, Hilde, Chen, Christopher, Cheung, Chin Wai, Chow, King Ngai, Chung, Henry Kwun Hang, Duering, Marco, Fu, Siu Ting, Gustafson, Deborah, Hilal, Saima, Hui, Vincent Ming Ho, Kalaria, Rajesh, Kim, SangYun, Lam, Maggie Li Man, de Leeuw, Frank Erik, Li, Ami Sin Man, Markus, Hugh Stephen, Marseglia, Anna, Zheng, Huijing, O’Brien, John, Pantoni, Leonardo, Sachdev, Perminder Singh, Smith, Eric E, Wardlaw, Joanna, and Mok, Vincent Chung Tong

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930221137019 for The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis by Bonnie Yin Ka Lam, Yuan Cai, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Chen, Chin Wai Cheung, King Ngai Chow, Henry Kwun Hang Chung, Marco Duering, Siu Ting Fu, Deborah Gustafson, Saima Hilal, Vincent Ming Ho Hui, Rajesh Kalaria, SangYun Kim, Maggie Li Man Lam, Frank Erik de Leeuw, Ami Sin Man Li, Hugh Stephen Markus, Anna Marseglia, Huijing Zheng, John O’Brien, Leonardo Pantoni, Perminder Singh Sachdev, Eric E Smith, Joanna Wardlaw and Vincent Chung Tong Mok in International Journal of Stroke

Published
2022
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16. Improved Sensitivity and Precision in Multicentre Diffusion MRI Network Analysis Using Thresholding and Harmonization

Author

de Brito Robalo, Bruno Miguel, primary, de Luca, Alberto, additional, Chen, Christopher, additional, Dewenter, Anna, additional, Duering, Marco, additional, Hilal, Saima, additional, Koek, Huiberdina L., additional, Kopczak, Anna, additional, Lam, Bonnie Yin Ka, additional, Leemans, Alexander, additional, Mok, Vincent CT, additional, Onkenhout, Laurien P., additional, van den Brink, Hilde, additional, and Biessels, Geert Jan, additional

Published
2022
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17. The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis.

Author

Lam, Bonnie Yin Ka, Cai, Yuan, Akinyemi, Rufus, Biessels, Geert Jan, van den Brink, Hilde, Chen, Christopher, Cheung, Chin Wai, Chow, King Ngai, Chung, Henry Kwun Hang, Duering, Marco, Fu, Siu Ting, Gustafson, Deborah, Hilal, Saima, Hui, Vincent Ming Ho, Kalaria, Rajesh, Kim, SangYun, Lam, Maggie Li Man, de Leeuw, Frank Erik, Li, Ami Sin Man, and Markus, Hugh Stephen

Subjects
*CEREBRAL small vessel diseases, *MIDDLE-income countries, *LACUNAR stroke, *MAGNETIC resonance imaging, *STROKE, *COMMUNITIES
Abstract

Background: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. Previous studies on the prevalence of cSVD are mostly based on single geographically defined cohorts in high-income countries. Studies investigating the prevalence of cSVD in low- and middle-income countries (LMICs) are expanding but have not been systematically assessed. Aim: This study aims to systematically review the prevalence of cSVD in LMICs. Results: Articles were searched from the Ovid MEDLINE and EMBASE databases from 1 January 2000 to 31 March 2022, without language restrictions. Title/abstract screening, full-text review, and data extraction were performed by two to seven independent reviewers. The prevalence of cSVD and study sample size were extracted by pre-defined world regions and health status. The Risk of Bias for Non-randomized Studies tool was used. The protocol was registered on PROSPERO (CRD42022311133). A meta-analysis of proportion was performed to assess the prevalence of different magnetic resonance imaging markers of cSVD, and a meta-regression was performed to investigate associations between cSVD prevalence and type of study, age, and male: female ratio. Of 2743 studies identified, 42 studies spanning 12 global regions were included in the systematic review. Most of the identified studies were from China (n = 23). The median prevalence of moderate-to-severe white matter hyperintensities (WMHs) was 20.5%, 40.5%, and 58.4% in the community, stroke, and dementia groups, respectively. The median prevalence of lacunes was 0.8% and 33.5% in the community and stroke groups. The median prevalence of cerebral microbleeds (CMBs) was 10.7% and 22.4% in the community and stroke groups. The median prevalence of moderate-to-severe perivascular spaces was 25.0% in the community. Meta-regression analyses showed that the weighted median age (51.4 ± 0.0 years old; range: 36.3–80.2) was a significant predictor of the prevalence of moderate-to-severe WMH and lacunes, while the type of study was a significant predictor of the prevalence of CMB. The heterogeneity of studies was high (>95%). Male participants were overrepresented. Conclusions: This systematic review and meta-analysis provide data on cSVD prevalence in LMICs and demonstrated the high prevalence of the condition. cSVD research in LMICs is being published at an increasing rate, especially between 2010 and 2022. More data are particularly needed from Sub-Saharan Africa and Central Europe, Eastern Europe, and Central Asia. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Erratum to: Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future (Alzheimer's & Dementia, (2020), 16, 11, (1571-1581), 10.1002/alz.12143)

Author

Mok, Vincent C. T., Pendlebury, Sarah, Wong, Adrian, Alladi, Suvarna, Au, Lisa, Bath, Philip M., Biessels, Geert Jan, Chen, Christopher, Cordonnier, Charlotte, Dichgans, Martin, Dominguez, Jacqueline, Gorelick, Philip B., Kim, SangYun, Kwok, Timothy, Greenberg, Steven M., Jia, Jianping, Kalaria, Rajesh, Kivipelto, Miia, Naegandran, Kandiah, Lam, Linda C. W., Lam, Bonnie Yin Ka, Lee, Allen T. C., Markus, Hugh S., O'Brien, John, Pai, Ming-Chyi, Pantoni, Leonardo, Sachdev, Perminder, Senanarong, Vorapun, Skoog, Ingmar, Smith, Eric E., Srikanth, Velandai, Suh, Guk-Hee, Wardlaw, Joanna, Ko, Ho, Black, Sandra E., Scheltens, Philip, Neurology, and Amsterdam Neuroscience - Neurodegeneration

Abstract

In the paper by Mok et al. (“Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.”Alzheimer's Dement. 2020; 16: 1571-1581. https://doi.org/10.1002/alz.12143), an error occurred in the preparation of the paper for publication, requiring the following correction. In the initial publication of this article, Vorapun Senanarong, BSc, MD, was inadvertently omitted from the author group. The corrected author group and affiliations list appear above. We regret the error.

Published
2021
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19. Erratum: Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future (Alzheimer's & Dementia, (2020), 16, 11, (1571-1581), 10.1002/alz.12143)

Author

Neurologen, Brain, Circulatory Health, Mok, Vincent C.T., Pendlebury, Sarah, Wong, Adrian, Alladi, Suvarna, Au, Lisa, Bath, Philip M., Biessels, Geert Jan, Chen, Christopher, Cordonnier, Charlotte, Dichgans, Martin, Dominguez, Jacqueline, Gorelick, Philip B., Kim, Sang Yun, Kwok, Timothy, Greenberg, Steven M., Jia, Jianping, Kalaria, Rajesh, Kivipelto, Miia, Naegandran, Kandiah, Lam, Linda C.W., Lam, Bonnie Yin Ka, Lee, Allen T.C., Markus, Hugh S., O'Brien, John, Pai, Ming Chyi, Pantoni, Leonardo, Sachdev, Perminder, Senanarong, Vorapun, Skoog, Ingmar, Smith, Eric E., Srikanth, Velandai, Suh, Guk Hee, Wardlaw, Joanna, Ko, Ho, Black, Sandra E., Scheltens, Philip, Neurologen, Brain, Circulatory Health, Mok, Vincent C.T., Pendlebury, Sarah, Wong, Adrian, Alladi, Suvarna, Au, Lisa, Bath, Philip M., Biessels, Geert Jan, Chen, Christopher, Cordonnier, Charlotte, Dichgans, Martin, Dominguez, Jacqueline, Gorelick, Philip B., Kim, Sang Yun, Kwok, Timothy, Greenberg, Steven M., Jia, Jianping, Kalaria, Rajesh, Kivipelto, Miia, Naegandran, Kandiah, Lam, Linda C.W., Lam, Bonnie Yin Ka, Lee, Allen T.C., Markus, Hugh S., O'Brien, John, Pai, Ming Chyi, Pantoni, Leonardo, Sachdev, Perminder, Senanarong, Vorapun, Skoog, Ingmar, Smith, Eric E., Srikanth, Velandai, Suh, Guk Hee, Wardlaw, Joanna, Ko, Ho, Black, Sandra E., and Scheltens, Philip

Published
2021

20. Erratum

Author

Mok, Vincent C.T., primary, Pendlebury, Sarah, additional, Wong, Adrian, additional, Alladi, Suvarna, additional, Au, Lisa, additional, Bath, Philip M, additional, Biessels, Geert Jan, additional, Chen, Christopher, additional, Cordonnier, Charlotte, additional, Dichgans, Martin, additional, Dominguez, Jacqueline, additional, Gorelick, Philip B., additional, Kim, SangYun, additional, Kwok, Timothy, additional, Greenberg, Steven M., additional, Jia, Jianping, additional, Kalaria, Rajesh, additional, Kivipelto, Miia, additional, Naegandran, Kandiah, additional, Lam, Linda C.W., additional, Lam, Bonnie Yin Ka, additional, Lee, Allen T.C., additional, Markus, Hugh S., additional, O'Brien, John, additional, Pai, Ming‐Chyi, additional, Pantoni, Leonardo, additional, Sachdev, Perminder, additional, Senanarong, Vorapun, additional, Skoog, Ingmar, additional, Smith, Eric E., additional, Srikanth, Velandai, additional, Suh, Guk‐Hee, additional, Wardlaw, Joanna, additional, Ko, Ho, additional, Black, Sandra E., additional, and Scheltens, Philip, additional

Published
2021
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21. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Best, Jonathan G, primary, Ambler, Gareth, additional, Wilson, Duncan, additional, Lee, Keon-Joo, additional, Lim, Jae-Sung, additional, Shiozawa, Masayuki, additional, Koga, Masatoshi, additional, Li, Linxin, additional, Lovelock, Caroline, additional, Chabriat, Hugues, additional, Hennerici, Michael, additional, Wong, Yuen Kwun, additional, Mak, Henry Ka Fung, additional, Prats-Sanchez, Luis, additional, Martínez-Domeño, Alejandro, additional, Inamura, Shigeru, additional, Yoshifuji, Kazuhisa, additional, Arsava, Ethem Murat, additional, Horstmann, Solveig, additional, Purrucker, Jan, additional, Lam, Bonnie Yin Ka, additional, Wong, Adrian, additional, Kim, Young Dae, additional, Song, Tae-Jin, additional, Lemmens, Robin, additional, Eppinger, Sebastian, additional, Gattringer, Thomas, additional, Uysal, Ender, additional, Tanriverdi, Zeynep, additional, Bornstein, Natan M, additional, Ben Assayag, Einor, additional, Hallevi, Hen, additional, Molad, Jeremy, additional, Nishihara, Masashi, additional, Tanaka, Jun, additional, Coutts, Shelagh B, additional, Polymeris, Alexandros, additional, Wagner, Benjamin, additional, Seiffge, David J, additional, Lyrer, Philippe, additional, Algra, Ale, additional, Kappelle, L Jaap, additional, Al-Shahi Salman, Rustam, additional, Jäger, Hans R, additional, Lip, Gregory Y H, additional, Fischer, Urs, additional, El-Koussy, Marwan, additional, Mas, Jean-Louis, additional, Legrand, Laurence, additional, Karayiannis, Christopher, additional, Phan, Thanh, additional, Gunkel, Sarah, additional, Christ, Nicolas, additional, Abrigo, Jill, additional, Leung, Thomas, additional, Chu, Winnie, additional, Chappell, Francesca, additional, Makin, Stephen, additional, Hayden, Derek, additional, Williams, David J, additional, Mess, Werner H, additional, Nederkoorn, Paul J, additional, Barbato, Carmen, additional, Browning, Simone, additional, Wiegertjes, Kim, additional, Tuladhar, Anil M, additional, Maaijwee, Noortje, additional, Guevarra, Anne Cristine, additional, Yatawara, Chathuri, additional, Mendyk, Anne-Marie, additional, Delmaire, Christine, additional, Köhler, Sebastian, additional, van Oostenbrugge, Robert, additional, Zhou, Ying, additional, Xu, Chao, additional, Hilal, Saima, additional, Gyanwali, Bibek, additional, Chen, Christopher, additional, Lou, Min, additional, Staals, Julie, additional, Bordet, Régis, additional, Kandiah, Nagaendran, additional, de Leeuw, Frank-Erik, additional, Simister, Robert, additional, Hendrikse, Jeroen, additional, Kelly, Peter J, additional, Wardlaw, Joanna, additional, Soo, Yannie, additional, Fluri, Felix, additional, Srikanth, Velandai, additional, Calvet, David, additional, Jung, Simon, additional, Kwa, Vincent I H, additional, Engelter, Stefan T, additional, Peters, Nils, additional, Smith, Eric E, additional, Hara, Hideo, additional, Yakushiji, Yusuke, additional, Orken, Dilek Necioglu, additional, Fazekas, Franz, additional, Thijs, Vincent, additional, Heo, Ji Hoe, additional, Mok, Vincent, additional, Veltkamp, Roland, additional, Ay, Hakan, additional, Imaizumi, Toshio, additional, Gomez-Anson, Beatriz, additional, Lau, Kui Kai, additional, Jouvent, Eric, additional, Rothwell, Peter M, additional, Toyoda, Kazunori, additional, Bae, Hee-Joon, additional, Marti-Fabregas, Joan, additional, Werring, David J, additional, Harkness, Kirsty, additional, Shaw, Louise, additional, Sword, Jane, additional, Mohd Nor, Azlisham, additional, Sharma, Pankaj, additional, Kelly, Deborah, additional, Harrington, Frances, additional, Randall, Marc, additional, Smith, Matthew, additional, Mahawish, Karim, additional, Elmarim, Abduelbaset, additional, Esisi, Bernard, additional, Cullen, Claire, additional, Nallasivam, Arumug, additional, Price, Christopher, additional, Barry, Adrian, additional, Roffe, Christine, additional, Coyle, John, additional, Hassan, Ahamad, additional, Birns, Jonathan, additional, Cohen, David, additional, Sekaran, Lakshmanan, additional, Parry-Jones, Adrian, additional, Parry, Anthea, additional, Hargroves, David, additional, Proschel, Harald, additional, Datta, Prabel, additional, Darawil, Khaled, additional, Manoj, Aravindakshan, additional, Burn, Mathew, additional, Patterson, Chris, additional, Giallombardo, Elio, additional, Smyth, Nigel, additional, Mansoor, Syed, additional, Anwar, Ijaz, additional, Marsh, Rachel, additional, Ispoglou, Sissi, additional, Chadha, Dinesh, additional, Prabhakaran, Mathuri, additional, Meenakishundaram, Sanjeevikumar, additional, O'Connell, Janice, additional, Scott, Jon, additional, Krishnamurthy, Vinodh, additional, Aghoram, Prasanna, additional, McCormick, Michael, additional, Sprigg, Nikola, additional, O'Mahony, Paul, additional, Cooper, Martin, additional, Choy, Lillian, additional, Wilkinson, Peter, additional, Leach, Simon, additional, Caine, Sarah, additional, Burger, Ilse, additional, Gunathilagan, Gunaratam, additional, Guyler, Paul, additional, Emsley, Hedley, additional, Davis, Michelle, additional, Manawadu, Dulka, additional, Pasco, Kath, additional, Mamun, Maam, additional, Luder, Robert, additional, Sajid, Mahmud, additional, Okwera, James, additional, Warburton, Elizabeth, additional, Saastamoinen, Kari, additional, England, Timothy, additional, Putterill, Janet, additional, Flossman, Enrico, additional, Power, Michael, additional, Dani, Krishna, additional, Mangion, David, additional, Suman, Appu, additional, Corrigan, John, additional, Lawrence, Enas, additional, Vahidassr, Djamil, additional, Shakeshaft, Clare, additional, Brown, Martin, additional, Charidimou, Andreas, additional, Cohen, Hannah, additional, Banerjee, Gargi, additional, Houlden, Henry, additional, White, Mark, additional, Yousry, Tarek, additional, Flossmann, Enrico, additional, Muir, Keith, additional, Gratz, Pascal, additional, Mattle, Heinrich, additional, Panos, Leonidas, additional, Korczyn, Amos, additional, Kliper, Efrat, additional, Maeder, Philippe, additional, Gass, Achim, additional, Pachai, Chahin, additional, Bracoub, Luc, additional, Douste-Blazy, Marie-Yvonne, additional, Fratacci, Marie Dominique, additional, Vicaut, Eric, additional, Sato, Shoichiro, additional, Miwa, Kaori, additional, Fujita, Kyohei, additional, Ide, Toshihiro, additional, Ma, Henry, additional, Ly, John, additional, Singhal, Shaloo, additional, Chandra, Ronil, additional, Slater, Lee-Anne, additional, Soufan, Cathy, additional, Moran, Christopher, additional, Traenka, Christopher, additional, Thilemann, Sebastian, additional, Fladt, Joachim, additional, Gensicke, Henrik, additional, Bonati, Leo, additional, Kim, Beom Joon, additional, Han, Moon-Ku, additional, Kang, Jihoon, additional, Ko, Eunbin, additional, Yang, Mi Hwa, additional, Jang, Myung Suk, additional, Murphy, Sean, additional, Carty, Fiona, additional, Akijian, Layan, additional, Thornton, John, additional, Schembri, Mark, additional, Douven, Elles, additional, Delgado-Mederos, Raquel, additional, Marín, Rebeca, additional, Camps-Renom, Pol, additional, Guisado-Alonso, Daniel, additional, Nuñez, Fidel, additional, Medrano-Martorell, Santiago, additional, Merino, Elisa, additional, Iida, Kotaro, additional, Ikeda, Syuhei, additional, Irie, Hiroyuki, additional, Demirelli, Derya Selcuk, additional, Medanta, Jayesh Modi, additional, Zerna, Charlotte, additional, Hernández, Maria Valdés, additional, Armitage, Paul, additional, Heye, Anna, additional, Muñoz-Maniega, Susana, additional, Sakka, Eleni, additional, Thrippleton, Michael, additional, Dennis, Martin, additional, Beigneux, Ysoline, additional, Silva, Mauro, additional, Venketasubramanian, Narayanaswamy, additional, Ho, Shu Leung, additional, Cheung, Raymond Tak Fai, additional, Chan, Koon Ho, additional, Teo, Kay Cheong, additional, Hui, Edward, additional, Kwan, Joseph Shiu Kwong, additional, Chang, Richard, additional, Tse, Man Yu, additional, Hoi, Chu Peng, additional, Chan, Chung Yan, additional, Chan, Oi Ling, additional, Cheung, Ryan Hoi Kit, additional, Wong, Edmund Ka Ming, additional, Leung, Kam Tat, additional, Tsang, Suk Fung, additional, Ip, Hing Lung, additional, Ma, Sze Ho, additional, Ma, Karen, additional, Fong, Wing Chi, additional, Li, Siu Hung, additional, Li, Richard, additional, Ng, Ping Wing, additional, Wong, Kwok Kui, additional, Liu, Wenyan, additional, Wong, Lawrence, additional, Ramos, Lino, additional, De Schryver, Els, additional, Jöbsis, Joost, additional, van der Sande, Jaap, additional, Brouwers, Paul, additional, Roos, Yvo, additional, Stam, Jan, additional, Bakker, Stef, additional, Verbiest, Henk, additional, Schoonewille, Wouter, additional, Linn, Cisca, additional, Hertzberger, Leopold, additional, van Gemert, Maarten, additional, Berntsen, Paul, additional, Van Dam-Nolen, Dianne, additional, Kooi, M Eline, additional, Van der Lugt, Aad, additional, Koudstaal, Peter, additional, Leff, Alexander, additional, Ward, Nicholas, additional, Nachev, Parashkev, additional, Perry, Richard, additional, Ozkan, Hatice, additional, and Mitchell, John, additional

Published
2021
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22. Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future

Author

Zorglijn AN/AAN Medisch, Brain, Circulatory Health, Mok, Vincent C T, Pendlebury, Sarah, Wong, Adrian, Alladi, Suvarna, Au, Lisa, Bath, Philip M, Biessels, Geert Jan, Chen, Christopher, Cordonnier, Charlotte, Dichgans, Martin, Dominguez, Jacqueline, Gorelick, Philip B, Kim, SangYun, Kwok, Timothy, Greenberg, Steven M, Jia, Jianping, Kalaria, Rajesh, Kivipelto, Miia, Naegandran, Kandiah, Lam, Linda C W, Lam, Bonnie Yin Ka, Lee, Allen T C, Markus, Hugh S, O'Brien, John, Pai, Ming-Chyi, Pantoni, Leonardo, Sachdev, Perminder, Skoog, Ingmar, Smith, Eric E, Srikanth, Velandai, Suh, Guk-Hee, Wardlaw, Joanna, Ko, Ho, Black, Sandra E, Scheltens, Philip, Zorglijn AN/AAN Medisch, Brain, Circulatory Health, Mok, Vincent C T, Pendlebury, Sarah, Wong, Adrian, Alladi, Suvarna, Au, Lisa, Bath, Philip M, Biessels, Geert Jan, Chen, Christopher, Cordonnier, Charlotte, Dichgans, Martin, Dominguez, Jacqueline, Gorelick, Philip B, Kim, SangYun, Kwok, Timothy, Greenberg, Steven M, Jia, Jianping, Kalaria, Rajesh, Kivipelto, Miia, Naegandran, Kandiah, Lam, Linda C W, Lam, Bonnie Yin Ka, Lee, Allen T C, Markus, Hugh S, O'Brien, John, Pai, Ming-Chyi, Pantoni, Leonardo, Sachdev, Perminder, Skoog, Ingmar, Smith, Eric E, Srikanth, Velandai, Suh, Guk-Hee, Wardlaw, Joanna, Ko, Ho, Black, Sandra E, and Scheltens, Philip

Published
2020

23. Pandemic of the aging society — sporadic cerebral small vessel disease

Author

Lau, Alexander Yuk Lun, primary, Ip, Bonaventure Yiu Ming, additional, Ko, Ho, additional, Lam, Bonnie Yin Ka, additional, Shi, Lin, additional, Ma, Karen Ka Yan, additional, Au, Lisa Wing Chi, additional, Soo, Yannie Oi Yan, additional, Leung, Thomas Wai Hong, additional, Wong, Adrian, additional, and Mok, Vincent Chung Tong, additional

Published
2021
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24. Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial

Author

Wong, Adrian, primary, Lam, Bonnie Yin Ka, additional, Mak, Margaret Kit Yi, additional, Lam, Linda Chiu Wa, additional, Au, Lisa Wing Chi, additional, Yiu, Brian Ka Fung, additional, Wong, Chun, additional, Tong, Hor Yee, additional, Yeung, Sin Ki, additional, Chu, Winnie Chiu Wing, additional, Shi, Lin, additional, Leung, Thomas Wai Hong, additional, Soo, Yannie Oi Yan, additional, Lau, Alexander Yuk Lun, additional, Ip, Bonaventure Yiu Ming, additional, Kwok, Timothy Chi Yui, additional, Ko, Ho, additional, and Mok, Vincent Chung Tong, additional

Published
2021
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26. A High Burden of Cerebral white Matter Lesion: Evidences from 9 Asian Cities

Author

Lam, Bonnie Yin Ka, primary, Yiu, Brian, additional, Ampil, Encarnita, additional, Chen, Christopher Li-Hsian, additional, Dikot, Yustiani, additional, Dominguez, Jacqueline, additional, Ganeshbhai, Patel Vishal, additional, Hilal, Saima, additional, Kandiah, Nagaendran, additional, Kim, SangYun, additional, Lee, Jun-Young, additional, Ong, Paulus Anam, additional, Senanarong, Vorapun, additional, Leung, Kam Tat, additional, Wang, Huali, additional, Yang, Yuan-Han, additional, Yong, Tingting, additional, Arshad, Faheem, additional, Alladi, Suvarna, additional, Wong, Samuel, additional, Ko, Ho, additional, Lau, Alexander Yuk Lun, additional, and Mok, Vincent Chung Tong, additional

Published
2020
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27. MRI-Based Alzheimer’s Disease-Resemblance Atrophy Index in the Detection of Preclinical and Prodromal Alzheimer’s Disease

Author

Liu, Wanting, primary, Au, Lisa Wing Chi, additional, Abrigo, Jill, additional, Luo, Yishan, additional, Wong, Adrian, additional, Lam, Bonnie Yin Ka, additional, Fan, Xiang, additional, Kwan, Pauline Wing Lam, additional, Ma, Hon Wing, additional, Ng, Anthea Yee Tung, additional, Chen, Sirong, additional, Leung, Eric Yim Lung, additional, Ho, Chi Lai, additional, Wong, Simon Ho Man, additional, Chu, Winnie CW, additional, Ko, Ho, additional, Lau, Alexander Yuk Lun, additional, Shi, Lin, additional, and Mok, Vincent Chung Tong, additional

Published
2020
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28. Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future

Author

Mok, Vincent C.T., primary, Pendlebury, Sarah, additional, Wong, Adrian, additional, Alladi, Suvarna, additional, Au, Lisa, additional, Bath, Philip M, additional, Biessels, Geert Jan, additional, Chen, Christopher, additional, Cordonnier, Charlotte, additional, Dichgans, Martin, additional, Dominguez, Jacqueline, additional, Gorelick, Philip B., additional, Kim, SangYun, additional, Kwok, Timothy, additional, Greenberg, Steven M., additional, Jia, Jianping, additional, Kalaria, Rajesh, additional, Kivipelto, Miia, additional, Naegandran, Kandiah, additional, Lam, Linda C.W., additional, Lam, Bonnie Yin Ka, additional, Lee, Allen T.C., additional, Markus, Hugh S., additional, O'Brien, John, additional, Pai, Ming‐Chyi, additional, Pantoni, Leonardo, additional, Sachdev, Perminder, additional, Skoog, Ingmar, additional, Smith, Eric E., additional, Srikanth, Velandai, additional, Suh, Guk‐Hee, additional, Wardlaw, Joanna, additional, Ko, Ho, additional, Black, Sandra E., additional, and Scheltens, Philip, additional

Published
2020
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29. Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors

Author

Brain, Opleiding Neurologie, Lam, Bonnie Yin Ka, Leung, Kam Tat, Yiu, Brian, Zhao, Lei, Biesbroek, J. Matthijs, Au, Lisa, Tang, Yumi, Wang, Kai, Fan, Yuhua, Fu, Jian Hui, Xu, Qun, Song, Haiqing, Tian, Xiaolin, Chu, Winnie Chiu Wing, Abrigo, Jill, Shi, Lin, Ko, Ho, Lau, Alexander, Duering, Marco, Wong, Adrian, Mok, Vincent Chung Tong, Brain, Opleiding Neurologie, Lam, Bonnie Yin Ka, Leung, Kam Tat, Yiu, Brian, Zhao, Lei, Biesbroek, J. Matthijs, Au, Lisa, Tang, Yumi, Wang, Kai, Fan, Yuhua, Fu, Jian Hui, Xu, Qun, Song, Haiqing, Tian, Xiaolin, Chu, Winnie Chiu Wing, Abrigo, Jill, Shi, Lin, Ko, Ho, Lau, Alexander, Duering, Marco, Wong, Adrian, and Mok, Vincent Chung Tong

Published
2019

31. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Wilson, Duncan, primary, Ambler, Gareth, additional, Lee, Keon-Joo, additional, Lim, Jae-Sung, additional, Shiozawa, Masayuki, additional, Koga, Masatoshi, additional, Li, Linxin, additional, Lovelock, Caroline, additional, Chabriat, Hugues, additional, Hennerici, Michael, additional, Wong, Yuen Kwun, additional, Mak, Henry Ka Fung, additional, Prats-Sánchez, Luis, additional, Martínez-Domeño, Alejandro, additional, Inamura, Shigeru, additional, Yoshifuji, Kazuhisa, additional, Arsava, Ethem Murat, additional, Horstmann, Solveig, additional, Purrucker, Jan, additional, Lam, Bonnie Yin Ka, additional, Wong, Adrian, additional, Kim, Young Dae, additional, Song, Tae-Jin, additional, Schrooten, Maarten, additional, Lemmens, Robin, additional, Eppinger, Sebastian, additional, Gattringer, Thomas, additional, Uysal, Ender, additional, Tanriverdi, Zeynep, additional, Bornstein, Natan M, additional, Assayag, Einor Ben, additional, Hallevi, Hen, additional, Tanaka, Jun, additional, Hara, Hideo, additional, Coutts, Shelagh B, additional, Hert, Lisa, additional, Polymeris, Alexandros, additional, Seiffge, David J, additional, Lyrer, Philippe, additional, Algra, Ale, additional, Kappelle, Jaap, additional, Al-Shahi Salman, Rustam, additional, Jäger, Hans R, additional, Lip, Gregory Y H, additional, Mattle, Heinrich P, additional, Panos, Leonidas D, additional, Mas, Jean-Louis, additional, Legrand, Laurence, additional, Karayiannis, Christopher, additional, Phan, Thanh, additional, Gunkel, Sarah, additional, Christ, Nicolas, additional, Abrigo, Jill, additional, Leung, Thomas, additional, Chu, Winnie, additional, Chappell, Francesca, additional, Makin, Stephen, additional, Hayden, Derek, additional, Williams, David J, additional, Kooi, M Eline, additional, van Dam-Nolen, Dianne H K, additional, Barbato, Carmen, additional, Browning, Simone, additional, Wiegertjes, Kim, additional, Tuladhar, Anil M, additional, Maaijwee, Noortje, additional, Guevarra, Christine, additional, Yatawara, Chathuri, additional, Mendyk, Anne-Marie, additional, Delmaire, Christine, additional, Köhler, Sebastian, additional, van Oostenbrugge, Robert, additional, Zhou, Ying, additional, Xu, Chao, additional, Hilal, Saima, additional, Gyanwali, Bibek, additional, Chen, Christopher, additional, Lou, Min, additional, Staals, Julie, additional, Bordet, Régis, additional, Kandiah, Nagaendran, additional, de Leeuw, Frank-Erik, additional, Simister, Robert, additional, van der Lugt, Aad, additional, Kelly, Peter J, additional, Wardlaw, Joanna M, additional, Soo, Yannie, additional, Fluri, Felix, additional, Srikanth, Velandai, additional, Calvet, David, additional, Jung, Simon, additional, Kwa, Vincent I H, additional, Engelter, Stefan T, additional, Peters, Nils, additional, Smith, Eric E, additional, Yakushiji, Yusuke, additional, Orken, Dilek Necioglu, additional, Fazekas, Franz, additional, Thijs, Vincent, additional, Heo, Ji Hoe, additional, Mok, Vincent, additional, Veltkamp, Roland, additional, Ay, Hakan, additional, Imaizumi, Toshio, additional, Gomez-Anson, Beatriz, additional, Lau, Kui Kai, additional, Jouvent, Eric, additional, Rothwell, Peter M, additional, Toyoda, Kazunori, additional, Bae, Hee-Joon, additional, Marti-Fabregas, Joan, additional, Werring, David J, additional, Harkness, Kirsty, additional, Shaw, Louise, additional, Sword, Jane, additional, Mohd Nor, Azlisham, additional, Sharma, Pankaj, additional, Kelly, Deborah, additional, Harrington, Frances, additional, Randall, Marc, additional, Smith, Matthew, additional, Mahawish, Karim, additional, Elmarim, Abduelbaset, additional, Esisi, Bernard, additional, Cullen, Claire, additional, Nallasivam, Arumug, additional, Price, Christopher, additional, Barry, Adrian, additional, Roffe, Christine, additional, Coyle, John, additional, Hassan, Ahamad, additional, Birns, Jonathan, additional, Cohen, David, additional, Sekaran, Lakshmanan, additional, Parry-Jones, Adrian, additional, Parry, Anthea, additional, Hargroves, David, additional, Proschel, Harald, additional, Datta, Prabel, additional, Darawil, Khaled, additional, Manoj, Aravindakshan, additional, Burn, Mathew, additional, Patterson, Chris, additional, Giallombardo, Elio, additional, Smyth, Nigel, additional, Mansoor, Syed, additional, Anwar, Ijaz, additional, Marsh, Rachel, additional, Ispoglou, Sissi, additional, Chadha, Dinesh, additional, Prabhakaran, Mathuri, additional, Meenakishundaram, Sanjeevikumar, additional, O'Connell, Janice, additional, Scott, Jon, additional, Krishnamurthy, Vinodh, additional, Aghoram, Prasanna, additional, McCormick, Michael, additional, Sprigg, Nikola, additional, O'Mahony, Paul, additional, Cooper, Martin, additional, Choy, Lillian, additional, Wilkinson, Peter, additional, Leach, Simon, additional, Caine, Sarah, additional, Burger, Ilse, additional, Gunathilagan, Gunaratam, additional, Guyler, Paul, additional, Emsley, Hedley, additional, Davis, Michelle, additional, Manawadu, Dulka, additional, Pasco, Kath, additional, Mamun, Maam, additional, Luder, Robert, additional, Sajid, Mahmud, additional, Okwera, James, additional, Warburton, Elizabeth, additional, Saastamoinen, Kari, additional, England, Timothy, additional, Putterill, Janet, additional, Flossman, Enrico, additional, Power, Michael, additional, Dani, Krishna, additional, Mangion, David, additional, Suman, Appu, additional, Corrigan, John, additional, Lawrence, Enas, additional, Vahidassr, Djamil, additional, Shakeshaft, Clare, additional, Brown, Martin, additional, Charidimou, Andreas, additional, Cohen, Hannah, additional, Banerjee, Gargi, additional, Houlden, Henry, additional, White, Mark, additional, Yousry, Tarek, additional, Flossmann, Enrico, additional, Muir, Keith, additional, El-Koussy, Marwan, additional, Gratz, Pascal, additional, Molad, Jeremy, additional, Korczyn, Amos, additional, Kliper, Efrat, additional, Maeder, Philippe, additional, Gass, Achim, additional, Pachai, Chahin, additional, Bracoub, Luc, additional, Douste-Blazy, Marie-Yvonne, additional, Fratacci, Marie Dominique, additional, Vicaut, Eric, additional, Sato, Shoichiro, additional, Miwa, Kaori, additional, Fujita, Kyohei, additional, Ide, Toshihiro, additional, Ma, Henry, additional, Ly, John, additional, Singhal, Shahoo, additional, Chandra, Ronil, additional, Slater, Lee-Anne, additional, Soufan, Cathy, additional, Moran, Christopher, additional, Traenka, Christopher, additional, Thilemann, Sebastian, additional, Fladt, Joachim, additional, Gensicke, Henrik, additional, Bonati, Leo, additional, Kim, Beom Joon, additional, Han, Moon-Ku, additional, Kang, Jihoon, additional, Ko, Eunbin, additional, Yang, Mi Hwa, additional, Jang, Myung Suk, additional, Murphy, Sean, additional, Carty, Fiona, additional, Akijian, Layan, additional, Thornton, John, additional, Schembri, Mark, additional, Douven, Elles, additional, Delgado-Mederos;, Raquel, additional, Marín, Rebeca, additional, Camps-Renom, Pol, additional, Guisado-Alonso, Daniel, additional, Nuñez, Fidel, additional, Medrano-Martorell, Santiago, additional, Merino, Elisa, additional, Iida, Kotaro, additional, Ikeda, Syuhei, additional, Nishihara, Masashi, additional, Irie, Hiroyuki, additional, Demirelli, Derya Selcuk, additional, Medanta, Jayesh Modi, additional, Zerna, Charlotte, additional, Hernández, Maria Valdés, additional, Armitage, Paul, additional, Heye, Anna, additional, Muñoz-Maniega, Susana, additional, Sakka, Eleni, additional, Thrippleton, Michael, additional, Dennis, Martin, additional, Beigneux, Ysoline, additional, Silva, Mauro, additional, Venketasubramanian, Narayanaswamy, additional, Ho, Shu Leung, additional, Cheung, Raymond Tak Fai, additional, Chan, Koon Ho, additional, Teo, Kay Cheong, additional, Hui, Edward, additional, Kwan, Joseph Shiu Kwong, additional, Chang, Richard, additional, Tse, Man Yu, additional, Hoi, Chu Peng, additional, Chan, Chung Yan, additional, Chan, Oi Ling, additional, Cheung, Ryan Hoi Kit, additional, Wong, Edmund Ka Ming, additional, Leung, Kam Tat, additional, Tsang, Suk Fung, additional, Ip, Hing Lung, additional, Ma, Sze Ho, additional, Ma, Karen, additional, Fong, Wing Chi, additional, Li, Siu Hung, additional, Li, Richard, additional, Ng, Ping Wing, additional, Wong, Kwok Kui, additional, Liu, Wenyan, additional, Wong, Lawrence, additional, Ramos, Lino, additional, De Schryver, Els, additional, Jöbsis, Joost, additional, van der Sande, Jaap, additional, Brouwers, Paul, additional, Roos, Yvo, additional, Stam, Jan, additional, Bakker, Stef, additional, Verbiest, Henk, additional, Schoonewille, Wouter, additional, Linn, Cisca, additional, Hertzberger, Leopold, additional, van Gemert, Maarten, additional, Berntsen, Paul, additional, Hendrikse, Jeroen, additional, Nederkoorn, Paul, additional, Mess, Werner, additional, Koudstaal, Peter, additional, Leff, Alexander, additional, Ward, Nicholas, additional, Nachev, Parashkev, additional, Perry, Richard, additional, Ozkan, Hatice, additional, and Mitchell, John, additional

Published
2019
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32. Modes of covariation between vascular risk factors and cognition in cohorts with cultural and geographical variations

Author

Lam, Bonnie Yin Ka, Hui, Vincent, Zheng, Huijing, Cai, Yuan, Griffanti, Ludovica, Suri, Sana, Ebmeier, Klaus P., Nichols, Thomas E., Mok, Vincent C.T., Johansen-Berg, Heidi, and Salvan, Piergiorgio

Abstract

The number of people living with dementia worldwide is growing. Devising and implementing preventive strategies that are globally applicable is of paramount importance. However, previous studies have largely been limited to cohorts that are geographically and culturally homogenous. It is not known whether the associations between demographics, vascular risk factors (VRFs), and cognitive changes are consistent across cohorts with cultural and geographical variations.

Published
2024
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33. Eating and hypothalamus changes in behavioral-variant frontotemporal dementia.

Author

Piguet, Olivier, Petersén, Åsa, Lam, Bonnie Yin Ka, Gabery, Sanaz, Murphy, Karen, Hodges, John R., and Halliday, Glenda M.

Subjects
FRONTOTEMPORAL dementia, HYPOTHALAMUS, FOOD habits, NEUROBEHAVIORAL disorders, DIENCEPHALON
Abstract

The article offers information on a study conducted to know the relation between eating and hypothalamus changes and behavioral-variant frontotemporal dementia (bvFTD). It states that 18 bvFTD patients and 16 healthy people underwent assessment of eating behavior and later postmortem analyses of 12 patients were performed. The study revealed that its patients exhibit significant atrophy of the hypothalamus.

Published
2011
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34. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Wilson, Duncan, Ambler, Gareth, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sánchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Schrooten, Maarten, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Assayag, Einor Ben, Hallevi, Hen, Tanaka, Jun, Hara, Hideo, Coutts, Shelagh B, Hert, Lisa, Polymeris, Alexandros, Seiffge, David J., Lyrer, Philippe, Algra, Ale, Kappelle, Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Mattle, Heinrich P., Panos, Leonidas D., Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Kooi, M Eline, Van Dam-Nolen, Dianne H K, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Christine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, Van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, De Leeuw, Frank-Erik, Simister, Robert, Van Der Lugt, Aad, Kelly, Peter J, Wardlaw, Joanna M, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Subjects
10. No inequality, 610 Medicine & health, 3. Good health
Abstract

BACKGROUND Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We therefore aimed to establish whether a large burden of cerebral microbleeds or particular anatomical patterns of cerebral microbleeds can identify ischaemic stroke or transient ischaemic attack patients at higher absolute risk of intracranial haemorrhage than ischaemic stroke. METHODS We did a pooled analysis of individual patient data from cohort studies in adults with recent ischaemic stroke or transient ischaemic attack. Cohorts were eligible for inclusion if they prospectively recruited adult participants with ischaemic stroke or transient ischaemic attack; included at least 50 participants; collected data on stroke events over at least 3 months follow-up; used an appropriate MRI sequence that is sensitive to magnetic susceptibility; and documented the number and anatomical distribution of cerebral microbleeds reliably using consensus criteria and validated scales. Our prespecified primary outcomes were a composite of any symptomatic intracranial haemorrhage or ischaemic stroke, symptomatic intracranial haemorrhage, and symptomatic ischaemic stroke. We registered this study with the PROSPERO international prospective register of systematic reviews, number CRD42016036602. FINDINGS Between Jan 1, 1996, and Dec 1, 2018, we identified 344 studies. After exclusions for ineligibility or declined requests for inclusion, 20 322 patients from 38 cohorts (over 35 225 patient-years of follow-up; median 1·34 years [IQR 0·19-2·44]) were included in our analyses. The adjusted hazard ratio [aHR] comparing patients with cerebral microbleeds to those without was 1·35 (95% CI 1·20-1·50) for the composite outcome of intracranial haemorrhage and ischaemic stroke; 2·45 (1·82-3·29) for intracranial haemorrhage and 1·23 (1·08-1·40) for ischaemic stroke. The aHR increased with increasing cerebral microbleed burden for intracranial haemorrhage but this effect was less marked for ischaemic stroke (for five or more cerebral microbleeds, aHR 4·55 [95% CI 3·08-6·72] for intracranial haemorrhage vs 1·47 [1·19-1·80] for ischaemic stroke; for ten or more cerebral microbleeds, aHR 5·52 [3·36-9·05] vs 1·43 [1·07-1·91]; and for ≥20 cerebral microbleeds, aHR 8·61 [4·69-15·81] vs 1·86 [1·23-1·82]). However, irrespective of cerebral microbleed anatomical distribution or burden, the rate of ischaemic stroke exceeded that of intracranial haemorrhage (for ten or more cerebral microbleeds, 64 ischaemic strokes [95% CI 48-84] per 1000 patient-years vs 27 intracranial haemorrhages [17-41] per 1000 patient-years; and for ≥20 cerebral microbleeds, 73 ischaemic strokes [46-108] per 1000 patient-years vs 39 intracranial haemorrhages [21-67] per 1000 patient-years). INTERPRETATION In patients with recent ischaemic stroke or transient ischaemic attack, cerebral microbleeds are associated with a greater relative hazard (aHR) for subsequent intracranial haemorrhage than for ischaemic stroke, but the absolute risk of ischaemic stroke is higher than that of intracranial haemorrhage, regardless of cerebral microbleed presence, antomical distribution, or burden. FUNDING British Heart Foundation and UK Stroke Association.

35. Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds.

Author

Fandler-Höfler S, Eppinger S, Ambler G, Nash P, Kneihsl M, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sanchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Lemmens R, Uysal E, Tanriverdi Z, Bornstein NM, Ben Assayag E, Hallevi H, Molad J, Nishihara M, Tanaka J, Coutts SB, Polymeris A, Wagner B, Seiffge DJ, Lyrer P, Kappelle LJ, Salman RA, Hernandez MV, Jäger HR, Lip GYH, Fischer U, El-Koussy M, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Chu W, Leung T, Chappell F, Makin S, Hayden D, Williams DJ, Mess WH, Kooi ME, Barbato C, Browning S, Tuladhar AM, Maaijwee N, Guevarra AC, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Robert C, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, Bos D, Kelly PJ, Wardlaw J, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Hara H, Yakushiji Y, Orken DN, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Wilson D, Best J, Fazekas F, Enzinger C, Werring DJ, and Gattringer T

Subjects
Humans, Male, Female, Aged, Middle Aged, Sex Factors, Magnetic Resonance Imaging, Prospective Studies, Severity of Illness Index, Cerebral Small Vessel Diseases epidemiology, Cerebral Small Vessel Diseases diagnostic imaging, Cerebral Small Vessel Diseases complications, Aged, 80 and over, Cohort Studies, Cerebral Hemorrhage epidemiology, Cerebral Hemorrhage diagnostic imaging, Cerebral Hemorrhage mortality
Abstract

Importance: Cerebral small vessel disease (SVD) is associated with various cerebrovascular outcomes, but data on sex differences in SVD are scarce., Objective: To investigate whether the frequency, severity, and distribution of cerebral microbleeds (CMB), other SVD markers on magnetic resonance imaging (MRI), and outcomes differ by sex., Design, Setting, and Participants: This cohort study used pooled individual patient data from the Microbleeds International Collaborative Network, including patients from 38 prospective cohort studies in 18 countries between 2000 and 2018, with clinical follow-up of at least 3 months (up to 5 years). Participants included patients with acute ischemic stroke or transient ischemic attack with available brain MRI. Data were analyzed from April to December 2023., Main Outcomes and Measures: Outcomes of interest were presence of CMB, lacunes, and severe white matter hyperintensities determined on MRI. Additionally, mortality, recurrent ischemic stroke, and intracranial hemorrhage during follow-up were assessed. Multivariable random-effects logistic regression models, Cox regression, and competing risk regression models were used to investigate sex differences in individual SVD markers, risk of recurrent cerebrovascular events, and death., Results: A total of 20 314 patients (mean [SD] age, 70.1 [12.7] years; 11 721 [57.7%] male) were included, of whom 5649 (27.8%) had CMB. CMB were more frequent in male patients, and this was consistent throughout different age groups, locations, and in multivariable models (female vs male adjusted odds ratio [aOR], 0.86; 95% CI, 0.80-0.92; P < .001). Female patients had fewer lacunes (aOR, 0.82; 95% CI, 0.74-0.90; P < .001) but a higher prevalence of severe white matter hyperintensities (aOR, 1.10; 95% CI, 1.01-1.20; P = .04) compared with male patients. A total of 2419 patients (11.9%) died during a median (IQR) follow-up of 1.4 (0.7-2.5) years. CMB presence was associated with a higher risk of mortality in female patients (hazard ratio, 1.15; 95% CI, 1.02-1.31), but not male patients (hazard ratio, 0.95; 95% CI, 0.84-1.07) (P for interaction = .01). A total of 1113 patients (5.5%) had recurrent ischemic stroke, and 189 patients (0.9%) had recurrent intracranial hemorrhage, with no sex differences., Conclusions and Relevance: This cohort study using pooled individual patient data found varying frequencies of individual SVD markers between female and male patients, indicating potential pathophysiological differences in manifestation and severity of SVD. Further research addressing differences in pathomechanisms and outcomes of SVD between female and male patients is required.

Published
2024
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36. Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial.

Author

Wong A, Lam BYK, Mak MKY, Lam LCW, Au LWC, Yiu BKF, Wong C, Tong HY, Yeung SK, Chu WCW, Shi L, Leung TWH, Soo YOY, Lau AYL, Ip BYM, Kwok TCY, Ko H, and Mok VCT

Abstract

Introduction: The benefit and risk of aerobic exercise among older people harboring advanced cerebral small vessel disease (CSVD) upon cognition, mood, and motor functions are unknown., Methods: This rater-blind randomized trial examined effects of a 24-week aerobic exercise training (60 min/session, twice/week) upon clinical (cognition, mood, motor functions) and hemodynamic (pulse pressure [PP], blood pressure [BP], pulsatility index) measures in older people harboring moderate to severe CSVD, as evidenced by confluent white matter hyperintensity and/or ≥2 lacunes on magnetic resonance imaging. We further investigated interactions between treatment conditions and hemodynamics measures., Results: Fifty-three and 54 subjects were randomized into the active and control group, respectively. There was no between-group difference in any of the clinical outcomes. The active group had a greater between-group reduction in systolic BP and PP than the control group. Within-group comparison showed that global cognition of the active group remained similar at end of the study compared to baseline, whereas it declined significantly in the control group. We observed "diverging" interaction effects in that greater reduction in systolic BP/PP was associated with greater improvement in memory functions and global cognition but worsening in processing speed in the active group. Side effects were comparable between the two groups., Discussion: Future study should investigate the mechanisms of the diverging impacts of aerobic exercise upon different cognitive domains so that the benefit-risk ratio of aerobic exercise in older people harboring more advanced CSVD can be better defined., Competing Interests: In the past 36 months, Adrian Wong reports payment from Hong Kong Court (payment made to him). Margaret Kit Yi Mak reports conference attendance support from The Hong Kong Polytechnic University to attend the XXVI World Congress on Parkinson's Disease and Related Disorders May 1–4, 2021. Linda Chiu Wa Lam reports consulting fees from the second expert Colloquium on Early Alzheimer's Disease organized by Eisai Pharmaceutical (zoom meeting in 2020); and giving a lecture and preparing a newsletter article on mental disorders for dentists for the Hong Kong Dental Association (2020); and she is a member of the Advisory Committee on Mental Health at the Food and Health Bureau of the HKSAR government. Sin Ki Yeung reports the provision of reading materials by the professor for the submitted work. Lin Shi reports grants from Hong Kong General Research Fund and Innovation and Technology Fund. Thomas Wai Hong Leung is the president of Hong Kong Neurological Society (unpaid). Yannie Oi Yan Soo reports grants from Hong Kong Health and Medical Research Fund (payment made to CUHK) and Emerging Markets Thrombosis Investigator‐Initiated Research Program from Pfizer (payment made to CUHK); and honorarium for being a speaker from Amgen (payment made to her), honorarium for being a speaker from Daiichi and Boehringer Ingelheim (Hong Kong) Ltd (payment made to CUHK); and support for conference attendance by Hong Kong Neurological and Hong Kong Stroke Societies (no direct payment involved). Timothy Chi Yui Kwok is the director of Jockey Club Centre for positive ageing, Hong Kong; reports honorarium for attending a hearing for guardianship board, Hong Kong; and payment from Hong Kong government for expert report for coroner office; and donation for research (donation made to CUHK). Ho Ko reports grants from Croucher Innovation Award, Collaborative Research Fund of the Research Grants Council, Hong Kong and Area of Excellence Scheme of the Research Grants Council, Hong Kong (payments made to CUHK); and consulting fees from Videns Incorporation Limited. He has patents on the identifications of new potential disease‐modifying therapeutics for Niemann‐Pick disease type C, a method for slowing down brain aging, and new methods for achieving rapid and deep immunostaining. All other authors declare no financial disclosures or conflicts of interest., (© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.)

Published
2021
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37. MRI-based Alzheimer's disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer's disease.

Author

Liu W, Au LWC, Abrigo J, Luo Y, Wong A, Lam BYK, Fan X, Kwan PWL, Ma HW, Ng AYT, Chen S, Leung EYL, Ho CL, Wong SHM, Chu WC, Ko H, Lau AYL, Shi L, and Mok VCT

Subjects
Aged, Alzheimer Disease pathology, Atrophy, Cognitive Dysfunction complications, Cognitive Dysfunction diagnostic imaging, Cohort Studies, Female, Hippocampus pathology, Humans, Male, Middle Aged, Temporal Lobe pathology, Alzheimer Disease diagnosis, Alzheimer Disease diagnostic imaging, Magnetic Resonance Imaging, Prodromal Symptoms
Abstract

Alzheimer's Disease-resemblance atrophy index (AD-RAI) is an MRI-based machine learning derived biomarker that was developed to reflect the characteristic brain atrophy associated with AD. Recent study showed that AD-RAI (≥0.5) had the best performance in predicting conversion from mild cognitive impairment (MCI) to dementia and from cognitively unimpaired (CU) to MCI. We aimed to validate the performance of AD-RAI in detecting preclinical and prodromal AD. We recruited 128 subjects (MCI=50, CU=78) from two cohorts: CU-SEEDS and ADNI. Amyloid (A+) and tau (T+) status were confirmed by PET ( 11 C-PIB, 18 F-T807) or CSF analysis. We investigated the performance of AD-RAI in detecting preclinical and prodromal AD (i.e. A+T+) among MCI and CU subjects and compared its performance with that of hippocampal measures. AD-RAI achieved the best metrics among all subjects (sensitivity 0.74, specificity 0.91, accuracy 85.94%) and among MCI subjects (sensitivity 0.92, specificity 0.81, accuracy 86.00%) in detecting A+T+ subjects over other measures. Among CU subjects, AD-RAI yielded the best specificity (0.95) and accuracy (85.90%) over other measures, while hippocampal volume achieved a higher sensitivity (0.73) than AD-RAI (0.47) in detecting preclinical AD. These results showed the potential of AD-RAI in the detection of early AD, in particular at the prodromal stage.

Published
2021
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