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Your search keyword '"Lam, W.K. Jacky"' showing total 7 results
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7 results on '"Lam, W.K. Jacky"'

1. Plasma Epstein–Barr Virus DNA and Risk of Future Nasopharyngeal Cancer

Author

Chan, K.C. Allen, primary, Lam, W.K. Jacky, additional, King, Ann, additional, Lin, Vivien S., additional, Lee, Patrick P.H., additional, Zee, Benny C.Y., additional, Chan, Stephen L., additional, Tse, Irene O.L., additional, Tsang, Amy F.C., additional, Li, Maggie Z.J., additional, Jiang, Peiyong, additional, Ai, Qi Yong H., additional, Poon, Darren M.C., additional, Au, K.H., additional, Hui, Edwin P., additional, Ma, Brigette B.Y., additional, Van Hasselt, Andrew C., additional, Chan, Anthony T.C., additional, Woo, John K.S., additional, and Lo, Y.M. Dennis, additional

Published
2023
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2. Supplementary Figure S1-S2 from Dynamic Changes of Post-Radiotherapy Plasma Epstein–Barr Virus DNA in a Randomized Trial of Adjuvant Chemotherapy Versus Observation in Nasopharyngeal Cancer

Author

Hui, Edwin Pun, primary, Ma, Brigette B.Y., primary, Lam, W.K. Jacky, primary, Chan, K.C. Allen, primary, Mo, Frankie, primary, Ai, Qi-yong Hemis, primary, King, Ann D., primary, Wong, Chi Hang, primary, Wong, Kenneth C.W., primary, Lam, Daisy C.M., primary, Tong, Macy, primary, Poon, Darren M.C., primary, Li, Leung, primary, Lau, Thomas K.H., primary, Wong, Kwan Hung, primary, Lo, Y.M. Dennis, primary, and Chan, Anthony T.C., primary

Published
2023
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3. Supplementary Table S1-S4 from Dynamic Changes of Post-Radiotherapy Plasma Epstein–Barr Virus DNA in a Randomized Trial of Adjuvant Chemotherapy Versus Observation in Nasopharyngeal Cancer

Author

Hui, Edwin Pun, primary, Ma, Brigette B.Y., primary, Lam, W.K. Jacky, primary, Chan, K.C. Allen, primary, Mo, Frankie, primary, Ai, Qi-yong Hemis, primary, King, Ann D., primary, Wong, Chi Hang, primary, Wong, Kenneth C.W., primary, Lam, Daisy C.M., primary, Tong, Macy, primary, Poon, Darren M.C., primary, Li, Leung, primary, Lau, Thomas K.H., primary, Wong, Kwan Hung, primary, Lo, Y.M. Dennis, primary, and Chan, Anthony T.C., primary

Published
2023
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4. Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma

Author

Che, Huiwen, Jiang, Peiyong, Choy, L.Y. Lois, Cheng, Suk Hang, Peng, Wenlei, Chan, Rebecca W.Y., Liu, Jing, Zhou, Qing, Lam, W.K. Jacky, Yu, Stephanie C.Y., Lau, So Ling, Leung, Tak Y., Wong, John, Wong, Vincent Wai-Sun, Wong, Grace L.H., Chan, Stephen L., Chan, K.C. Allen, and Lo, Y.M. Dennis

Abstract

Recent studies have revealed an unexplored population of long cell-free DNA (cfDNA) molecules in human plasma using long-read sequencing technologies. However, the biological properties of long cfDNA molecules (>500 bp) remain largely unknown. To this end, we have investigated the origins of long cfDNA molecules from different genomic elements. Analysis of plasma cfDNA using long-read sequencing reveals an uneven distribution of long molecules from across the genome. Long cfDNA molecules show overrepresentation in euchromatic regions of the genome, in sharp contrast to short DNA molecules. We observe a stronger relationship between the abundance of long molecules and mRNA gene expression levels, compared with short molecules (Pearson's r= 0.71 vs. −0.14). Moreover, long and short molecules show distinct fragmentation patterns surrounding CpG sites. Leveraging the cleavage preferences surrounding CpG sites, the combined cleavage ratios of long and short molecules can differentiate patients with hepatocellular carcinoma (HCC) from non-HCC subjects (AUC = 0.87). We also investigated knockout mice in which selected nuclease genes had been inactivated in comparison with wild-type mice. The proportion of long molecules originating from transcription start sites are lower in Dffb-deficient mice but higher in Dnase1l3-deficient mice compared with that of wild-type mice. This work thus provides new insights into the biological properties and potential clinical applications of long cfDNA molecules.

Published
2024
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5. Dynamic Changes of Post-Radiotherapy Plasma Epstein–Barr Virus DNA in a Randomized Trial of Adjuvant Chemotherapy Versus Observation in Nasopharyngeal Cancer

Author

Hui, Edwin Pun, primary, Ma, Brigette B.Y., additional, Lam, W.K. Jacky, additional, Chan, K.C. Allen, additional, Mo, Frankie, additional, Ai, Qi-yong Hemis, additional, King, Ann D., additional, Wong, Chi Hang, additional, Wong, Kenneth C.W., additional, Lam, Daisy C.M., additional, Tong, Macy, additional, Poon, Darren M.C., additional, Li, Leung, additional, Lau, Thomas K.H., additional, Wong, Kwan Hung, additional, Lo, Y.M. Dennis, additional, and Chan, Anthony T.C., additional

Published
2021
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6. Plasma DNA End-Motif Profiling as a Fragmentomic Marker in Cancer, Pregnancy, and Transplantation

Author

Jiang, Peiyong, primary, Sun, Kun, additional, Peng, Wenlei, additional, Cheng, Suk Hang, additional, Ni, Meng, additional, Yeung, Philip C., additional, Heung, Macy M.S., additional, Xie, Tingting, additional, Shang, Huimin, additional, Zhou, Ze, additional, Chan, Rebecca W.Y., additional, Wong, John, additional, Wong, Vincent W.S., additional, Poon, Liona C., additional, Leung, Tak Yeung, additional, Lam, W.K. Jacky, additional, Chan, Jason Y.K., additional, Chan, Henry L.Y., additional, Chan, K.C. Allen, additional, Chiu, Rossa W.K., additional, and Lo, Y.M. Dennis, additional

Published
2020
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7. Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer

Author

Chan, K.C. Allen, primary, Woo, John K.S., additional, King, Ann, additional, Zee, Benny C.Y., additional, Lam, W.K. Jacky, additional, Chan, Stephen L., additional, Chu, Sam W.I., additional, Mak, Constance, additional, Tse, Irene O.L., additional, Leung, Samantha Y.M., additional, Chan, Gloria, additional, Hui, Edwin P., additional, Ma, Brigette B.Y., additional, Chiu, Rossa W.K., additional, Leung, Sing-Fai, additional, van Hasselt, Andrew C., additional, Chan, Anthony T.C., additional, and Lo, Y.M. Dennis, additional

Published
2017
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