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145 results on '"Lambert, G. W."'

5. Content and delivery preferences for information to support the management of high blood pressure

Author

Chapman, N., primary, Marques, F. Z., additional, Picone, D. S., additional, Adji, A., additional, Broughton, B. R. S., additional, Dinh, Q. N., additional, Gabb, G., additional, Lambert, G. W., additional, Mihailidou, A. S., additional, Nelson, M. R., additional, Stowasser, M., additional, Schlaich, M., additional, Schultz, M. G., additional, Mynard, J. P., additional, and Climie, R. E., additional

Published
2022
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20. Norepinephrine transporter expression is inversely associated with glycaemic indices: a pilot study in metabolically diverse persons with overweight and obesity

Author

Straznicky, N. E., primary, Guo, L., additional, Corcoran, S. J., additional, Esler, M. D., additional, Phillips, S. E., additional, Sari, C. I., additional, Grima, M. T., additional, Karapanagiotidis, S., additional, Wong, C. Y., additional, Eikelis, N., additional, Mariani, J. A., additional, Kobayashi, D., additional, Dixon, J. B., additional, Lambert, G. W., additional, and Lambert, E. A., additional

Published
2016
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26. The effects of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects

Author

Straznicky, N. E., primary, Lambert, E. A., additional, Grima, M. T., additional, Eikelis, N., additional, Nestel, P. J., additional, Dawood, T., additional, Schlaich, M. P., additional, Masuo, K., additional, Chopra, R., additional, Sari, C. I., additional, Dixon, J. B., additional, Tilbrook, A. J., additional, and Lambert, G. W., additional

Published
2011
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28. Seasonal differences in the effect of isolation and restraint stress on the luteinizing hormone response to gonadotropin-releasing hormone in hypothalamopituitary disconnected, gonadectomized rams and ewes

Author

Stackpole, C. A., Turner, A. I., Clarke, I. J., Lambert, G. W., Tilbrook, A. J., Stackpole, C. A., Turner, A. I., Clarke, I. J., Lambert, G. W., and Tilbrook, A. J.

Abstract

Stress responses are thought to act within the hypothalamopituitary unit to impair the reproductive system, and the sites of action may differ between sexes. The effect of isolation and restraint stress on pituitary responsiveness to GnRH in sheep was investigated, with emphasis on possible sex differences. Experiments were conducted during the breeding season and the nonbreeding season. In both experiments, 125 ng of GnRH was injected i.v. every 2 h into hypothalamopituitary disconnected, gonadectomized rams and ewes on 3 experimental days, with each day divided into two periods. During the second period on Day 2, isolation and restraint stress was imposed for 5.5 h. Plasma concentrations of LH and cortisol were measured in samples of blood collected from the jugular vein. In the second experiment (nonbreeding season), plasma concentrations of epinephrine, norepinephrine, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylglycol were also measured. In both experiments, there was no effect of isolation and restraint stress on plasma concentrations of cortisol in either sex. During the breeding season, there was no effect of isolation and restraint stress on plasma concentrations of LH in either sex. During the nonbreeding season, the amplitude of the first LH pulse after the commencement of stress was significantly reduced (P < 0.05) in rams and ewes. In the second experiment, during stress there was a significant increase (P < 0.05) in plasma concentrations of epinephrine in rams and ewes and significantly higher (P < 0.05) basal concentrations of norepinephrine in ewes than in rams. These results suggest that in sheep stress reduces responsiveness of the pituitary gland to exogenous GnRH during the nonbreeding season but not during the breeding season, possibly because of mediators of the stress response other than those of the hypothalamus-pituitary-adrenal gland axis.

Published
2003

32. Aging effects on human sympathetic neuronal function

Author

Esler, M. D., primary, Turner, A. G., additional, Kaye, D. M., additional, Thompson, J. M., additional, Kingwell, B. A., additional, Morris, M., additional, Lambert, G. W., additional, Jennings, G. L., additional, Cox, H. S., additional, and Seals, D. R., additional

Published
1995
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40. Effect of sunlight and season on serotonin turnover in the brain.

Author

Lambert, G W, Reid, C, Kaye, D M, Jennings, G L, and Esler, M D

Subjects
*SEASONAL affective disorder, *NEUROTRANSMITTERS, *SEROTONIN, *SUNSHINE, *PHYSIOLOGICAL effects of solar radiation
Abstract

Alterations in monoaminergic neurotransmission in the brain are thought to underlie seasonal variations in mood, behaviour, and affective disorders. We took blood samples from internal jugular veins in 101 healthy men, to assess the relation between concentration of serotonin metabolite in these samples and weather conditions and season. We showed that turnover of serotonin by the brain was lowest in winter (p=0.013). Moreover, the rate of production of serotonin by the brain was directly related to the prevailing duration of bright sunlight (r=0.294, p=0.010), and rose rapidly with increased luminosity. Our findings are further evidence for the notion that changes in release of serotonin by the brain underlie mood seasonality and seasonal affective disorder. [ABSTRACT FROM AUTHOR]

Published
2002
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47. Evidence for Reduced Myocardial Sympathetic Innervation in Human Essential Hypertension.

Author

Schlaich, M. P. Z, Lambert, E. A., Lambert, G. W., and Esler, M. D.

Subjects
HYPERTENSION, TISSUES, METABOLITES, GROWTH factors, BLOOD circulation disorders
Abstract

Objective: Essential hypertension is commonly associated with sympathetic activation. The precise causal mechanisms leading to sympathetic activation in hypertensive subjects are still poorly understood. Amongst others, possible explanations include sympathetic hyperinnervation of target tissues, as evident in the spontaneously hypertensive rat. Methods: To further address this issue we combined biochemical measurements of cardiac NE stores (n = 112), measured from the rate of overflow of the NE metabolite, dihydroxyphenylglycol (DHPG), and its tritiated form into the coronary sinus during an infusion of ([³H]NE), with 123 I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy (n = 16) as indices of cardiac sympathetic innervation in normotensive (NT: n = 73/8) and hypertensive (EH: n = 39/8) subjects. To complement these data, we also determined the transcardiac gradients for plasma nerve growth factor (NGF) (ELISA), a neurotrophin produced and released by target tissues which plays a pivotal role in the differentiation, maturation and survival of sympathetic neurons. Results: Cardiac NE stores were substantially reduced in hypertensive subjects (NT: 713 ± 67 vs EH: 328 ± 180 nmol; p < 0.05). The heart-to-mediastinum (H/M) uptake ratio of MIBG was significantly lower in the hypertensive group (NT: 2.31 ± 0.12 vs EH: 1.98 ± 0.20; p < 0.01). Furthermore, the plasma NGF gradient across the heart was reduced in hypertensive patients (NT: 21.1 ± 6.6 vs EH: -5.8 ± 6.2 pg/ml; p < 0.05). Conclusions: In contrast to animal models of hypertension, these data provide biochemical, scintigraphic and biological evidence for reduced myocardial sympathetic innervation in human essential hypertension. [ABSTRACT FROM AUTHOR]

Published
2004

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