Search

Your search keyword '"Lambregts, Doenja M J"' showing total 401 results
Start Over Author "Lambregts, Doenja M J"
401 results on '"Lambregts, Doenja M J"'

1. Identifying the primary tumour in patients with cancer of unknown primary (CUP) using [18F]FDG PET/CT: a systematic review and individual patient data meta-analysis

Author

Willemse, Jeroen R. J., Lambregts, Doenja M. J., Balduzzi, Sara, Schats, Winnie, Snaebjornsson, Petur, Marchetti, Serena, Vollebergh, Marieke A., van Golen, Larissa W., Cheung, Zing, Vogel, Wouter V., Bodalal, Zuhir, Rostami, Sajjad, Gerke, Oke, Sivakumaran, Tharani, Beets-Tan, Regina G.H., and Lahaye, Max J.

Published
2024
Full Text
View/download PDF

4. Imaging in pelvic exenteration—a multidisciplinary practice guide from the ESGAR-SAR-ESUR-PelvEx collaborative group

Author

Nougaret, Stephanie, Lambregts, Doenja M. J., Beets, Geerard L., Beets-Tan, Regina G. H., Blomqvist, Lennart, Burling, David, Denost, Quentin, Gambacorta, Maria A., Gui, Benedetta, Klopp, Ann, Lakhman, Yulia, Maturen, Kate E., Manfredi, Riccardo, Petkovska, Iva, Russo, Luca, Shinagare, Atul B., Stephenson, James A., Tolan, Damian, Venkatesan, Aradhana M., Quyn, Aaron J., and Forstner, Rosemarie

Published
2024
Full Text
View/download PDF

8. Development and multicenter validation of a multiparametric imaging model to predict treatment response in rectal cancer

Author

Schurink, Niels W., van Kranen, Simon R., van Griethuysen, Joost J. M., Roberti, Sander, Snaebjornsson, Petur, Bakers, Frans C. H., de Bie, Shira H., Bosma, Gerlof P. T., Cappendijk, Vincent C., Geenen, Remy W. F., Neijenhuis, Peter A., Peterson, Gerald M., Veeken, Cornelis J., Vliegen, Roy F. A., Peters, Femke P., Bogveradze, Nino, el Khababi, Najim, Lahaye, Max J., Maas, Monique, Beets, Geerard L., Beets-Tan, Regina G. H., and Lambregts, Doenja M. J.

Published
2023
Full Text
View/download PDF

13. Current controversies in TNM for the radiological staging of rectal cancer and how to deal with them: results of a global online survey and multidisciplinary expert consensus

Author

Lambregts, Doenja M. J., Bogveradze, Nino, Blomqvist, Lennart K., Fokas, Emmanouil, Garcia-Aguilar, Julio, Glimelius, Bengt, Gollub, Marc J., Konishi, Tsuyoshi, Marijnen, Corrie A. M., Nagtegaal, Iris D., Nilsson, Per J., Perez, Rodrigo O., Snaebjornsson, Petur, Taylor, Stuart A., Tolan, Damian J. M., Valentini, Vincenzo, West, Nicholas P., Wolthuis, Albert, Lahaye, Max J., Maas, Monique, Beets, Geerard L., and Beets-Tan, Regina G.H.

Published
2022
Full Text
View/download PDF

14. Identifying the primary tumour in patients with cancer of unknown primary (CUP) using [18F]FDG PET/CT: a systematic review and individual patient data meta-analysis.

Author

Willemse, Jeroen R. J., Lambregts, Doenja M. J., Balduzzi, Sara, Schats, Winnie, Snaebjornsson, Petur, Marchetti, Serena, Vollebergh, Marieke A., van Golen, Larissa W., Cheung, Zing, Vogel, Wouter V., Bodalal, Zuhir, Rostami, Sajjad, Gerke, Oke, Sivakumaran, Tharani, Beets-Tan, Regina G.H., and Lahaye, Max J.

Subjects
*CANCER of unknown primary origin, *CANCER patients, *BONE metastasis, *MOLECULAR oncology, *POSITRON emission tomography computed tomography, *LUNGS
Abstract

Purpose: In this systematic review and individual patient data (IPD) meta-analysis, we analysed the diagnostic performance of [18F]FDG PET/CT in detecting primary tumours in patients with CUP and evaluated whether the location of the predominant metastatic site influences the diagnostic performance. Methods: A systematic literature search from January 2005 to February 2024 was performed to identify articles describing the diagnostic performance of [18F]FDG PET/CT for primary tumour detection in CUP. Individual patient data retrieved from original articles or obtained from corresponding authors were grouped by the predominant metastatic site. The diagnostic performance of [18F]FDG PET/CT in detecting the underlying primary tumour was compared between predominant metastatic sites. Results: A total of 1865 patients from 32 studies were included. The largest subgroup included patients with predominant bone metastases (n = 622), followed by liver (n = 369), lymph node (n = 358), brain (n = 316), peritoneal (n = 70), lung (n = 67), and soft tissue (n = 23) metastases, leaving a small group of other/undefined metastases (n = 40). [18F]FDG PET/CT resulted in pooled detection rates to identify the primary tumour of 0.74 (for patients with predominant brain metastases), 0.54 (liver-predominant), 0.49 (bone-predominant), 0.46 (lung-predominant), 0.38 (peritoneal-predominant), 0.37 (lymph node-predominant), and 0.35 (soft-tissue-predominant). Conclusion: This individual patient data meta-analysis suggests that the ability of [18F]FDG PET/CT to identify the primary tumour in CUP depends on the distribution of metastatic sites. This finding emphasises the need for more tailored diagnostic approaches in different patient populations. In addition, alternative diagnostic tools, such as new PET tracers or whole-body (PET/)MRI, should be investigated. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Sources of variation in multicenter rectal MRI data and their effect on radiomics feature reproducibility

Author

Schurink, Niels W., van Kranen, Simon R., Roberti, Sander, van Griethuysen, Joost J. M., Bogveradze, Nino, Castagnoli, Francesca, el Khababi, Najim, Bakers, Frans C. H., de Bie, Shira H., Bosma, Gerlof P. T., Cappendijk, Vincent C., Geenen, Remy W. F., Neijenhuis, Peter A., Peterson, Gerald M., Veeken, Cornelis J., Vliegen, Roy F. A., Beets-Tan, Regina G. H., and Lambregts, Doenja M. J.

Published
2022
Full Text
View/download PDF

27. Rectum

Author

Lambregts, Doenja M. J., Beets-Tan, Regina G. H., Gourtsoyianni, Sofia, editor, and Papanikolaou, Nikolaos, editor

Published
2019
Full Text
View/download PDF

28. Imaging in the era of risk-adapted treatment in colon cancer.

Author

Lahaye, Max J, Lambregts, Doenja M J, Aalbers, Arend G J, Snaebjornsson, Petur, Beets-Tan, Regina G H, and Kok, Niels F M

Subjects
*COLON cancer, *NEOADJUVANT chemotherapy, *METASTASIS, *CANCER patients, *CANCER treatment
Abstract

The treatment landscape for patients with colon cancer is continuously evolving. Risk-adapted treatment strategies, including neoadjuvant chemotherapy and immunotherapy, are slowly finding their way into clinical practice and guidelines. Radiologists are pivotal in guiding clinicians toward the most optimal treatment for each colon cancer patient. This review provides an overview of recent and upcoming advances in the diagnostic management of colon cancer and the radiologist's role in the multidisciplinary approach to treating colon cancer. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Impact of the new rectal cancer definition on multimodality treatment and interhospital variability: Results from a nationwide cross‐sectional study.

Author

Hazen, Sanne‐Marije J. A., Sluckin, Tania C., Horsthuis, Karin, Lambregts, Doenja M. J., Beets‐Tan, Regina G. H., Hompes, Roel, Buffart, Tineke E., Marijnen, Corrie A. M., Tanis, Pieter J., Kusters, Miranda, Aalbers, Arend G. J., van Aalten, Susanna M., Amelung, Femke J., Ankersmit, Marjolein, Antonisse, Imogeen E., Ashruf, Jesse F., Aukema, Tjeerd S., Avenarius, Henk, Bahadoer, Renu R., and Bakers, Frans C. H.

Subjects
RECTAL cancer, COLON cancer, DELPHI method, CROSS-sectional method, PROGNOSIS
Abstract

Aim: This study aimed to determine the consequences of the new definition of rectal cancer for decision‐making in multidisciplinary team meetings (MDT). The new definition of rectal cancer, the lower border of the tumour is located below the sigmoid take‐off (STO), was implemented in the Dutch guideline in 2019 after an international Delphi consensus meeting to reduce interhospital variations. Method: All patients with rectal cancer according to the local MDT, who underwent resection in 2016 in the Netherlands were eligible for this nationwide collaborative cross‐sectional study. MRI‐images were rereviewed, and the tumours were classified as above or on/below the STO. Results: This study registered 3107 of the eligible 3178 patients (98%), of which 2784 patients had an evaluable MRI. In 314 patients, the tumour was located above the STO (11%), with interhospital variation between 0% and 36%. Based on TN‐stage, 175 reclassified patients with colon cancer (6%) would have received different treatment (e.g., omitting neoadjuvant radiotherapy, candidate for adjuvant chemotherapy). Tumour location above the STO was independently associated with lower risk of 4‐year locoregional recurrence (HR 0.529; p = 0.030) and higher 4‐year overall survival (HR 0.732; p = 0.037) compared to location under the STO. Conclusion: By using the STO, 11% of the prior MDT‐based diagnosis of rectal cancer were redefined as sigmoid cancer, with potential implications for multimodality treatment and prognostic value. Given the substantial interhospital variation in proportion of redefined cancers, the use of the STO will contribute to standardisation and comparability of outcomes in both daily practice and trial settings. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

30. Whole‐body MRI with diffusion‐weighted imaging as an adjunct to18F‐fluorodeoxyglucose positron emission tomography and CT in patients with suspected recurrent colorectal cancer

Author

Willemse, Jeroen R. J., primary, Lahaye, Max J., additional, Kok, Niels F. M., additional, Grotenhuis, Brechtje A., additional, Aalbers, Arend G. J., additional, Beets, Geerard L., additional, Rijsemus, Charlotte, additional, Maas, Monique, additional, van Golen, Larissa W., additional, Beets‐Tan, Regina G. H., additional, and Lambregts, Doenja M. J., additional

Published
2023
Full Text
View/download PDF

31. Independent validation of CT radiomics models in colorectal liver metastases: predicting local tumour progression after ablation

Author

van der Reijd, Denise J., primary, Guerendel, Corentin, additional, Staal, Femke C. R., additional, Busard, Milou P., additional, De Oliveira Taveira, Mateus, additional, Klompenhouwer, Elisabeth G., additional, Kuhlmann, Koert F. D., additional, Moelker, Adriaan, additional, Verhoef, Cornelis, additional, Starmans, Martijn P. A., additional, Lambregts, Doenja M. J., additional, Beets-Tan, Regina G. H., additional, Benson, Sean, additional, and Maas, Monique, additional

Published
2023
Full Text
View/download PDF

38. Outcomes and potential impact of a virtual hands-on training program on MRI staging confidence and performance in rectal cancer

Author

El Khababi, Najim, primary, Beets-Tan, Regina G. H., additional, Tissier, Renaud, additional, Lahaye, Max J., additional, Maas, Monique, additional, Curvo-Semedo, Luís, additional, Dresen, Raphaëla C., additional, van Griethuysen, Joost J. M., additional, Nougaret, Stephanie, additional, Beets, Geerard L., additional, van Triest, Baukelien, additional, Taylor, Stuart A., additional, and Lambregts, Doenja M. J., additional

Published
2023
Full Text
View/download PDF

39. Accurate surgical navigation with real-time tumor tracking in cancer surgery

Author

Kok, Esther N. D., Eppenga, Roeland, Kuhlmann, Koert F. D., Groen, Harald C., van Veen, Ruben, van Dieren, Jolanda M., de Wijkerslooth, Thomas R., van Leerdam, Monique, Lambregts, Doenja M. J., Heerink, Wouter J., Hoetjes, Nikie J., Ivashchenko, Oleksandra, Beets, Geerard L., Aalbers, Arend G. J., Nijkamp, Jasper, and Ruers, Theo J. M.

Published
2020
Full Text
View/download PDF

42. Comparison of MRI response evaluation methods in rectal cancer: a multicentre and multireader validation study

Author

El Khababi, Najim, Beets-Tan, Regina G H, Tissier, Renaud, Lahaye, Max J, Maas, Monique, Curvo-Semedo, Luís, Dresen, Raphaëla C, Nougaret, Stephanie, Beets, Geerard L, Lambregts, Doenja M J, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, School Office GROW, Faculteit FHML Centraal, and RS: GROW - R1 - Prevention

Subjects
Magnetic resonance imaging, Residual, Neoplasm, Rectal neoplasms, Radiology, Nuclear Medicine and imaging, Chemoradiotherapy, General Medicine
Abstract

Objectives: To compare four previously published methods for rectal tumor response evaluation after chemoradiotherapy on MRI. Methods: Twenty-two radiologists (5 rectal MRI experts, 17 general/abdominal radiologists) retrospectively reviewed the post-chemoradiotherapy MRIs of 90 patients, scanned at 10 centers (with non-standardized protocols). They applied four response methods; two based on T2W-MRI only (MRI tumor regression grade (mrTRG); split-scar sign), and two based on T2W-MRI+DWI (modified-mrTRG; DWI-patterns). Image quality was graded using a 0–6-point score (including slice thickness and in-plane resolution; sequence angulation; DWI b-values, signal-to-noise, and artefacts); scores < 4 were classified below average. Mixed model linear regression was used to calculate average sensitivity/specificity/accuracy to predict a complete response (versus residual tumor) and assess the impact of reader experience and image quality. Group interobserver agreement (IOA) was calculated using Krippendorff’s alpha. Readers were asked to indicate their preferred scoring method(s). Results: Average sensitivity/specificity/accuracy was 57%/64%/62% (mrTRG), 36%/79%/66% (split-scar), 40%/79%/67% (modified-mrTRG), and 37%/82%/68% (DWI-patterns); mrTRG showed higher sensitivity but lower specificity and accuracy (p < 0.001) compared to the other methods. IOA was lower for the split scar method (0.18 vs. 0.39–0.43). Higher reader experience had a significant positive effect on diagnostic performance and IOA (except for the split scar sign); below-average imaging quality had a significant negative effect on diagnostic performance. DWI pattern was selected as the preferred method by 73% of readers. Conclusions: Methods incorporating DWI showed the most favorable results when combining diagnostic performance, IOA, and reader preference. Reader experience and image quality clearly impacted diagnostic performance emphasizing the need for state-of-the-art imaging and dedicated radiologist training. Key Points: • In a multireader study comparing 4 MRI methods for rectal tumor response evaluation, those incorporating DWI showed the best results when combining diagnostic performance, IOA, and reader preference. • The most preferred method (by 73% of readers) was the “DWI patterns” approach with an accuracy of 68%, high specificity of 82%, and group IOA of 0.43. • Reader experience level and MRI quality had an evident effect on diagnostic performance and IOA.

Published
2022
Full Text
View/download PDF

43. Whole‐body MRI with diffusion‐weighted imaging as an adjunct to18F‐fluorodeoxyglucose positron emission tomography and CT in patients with suspected recurrent colorectal cancer.

Author

Willemse, Jeroen R. J., Lahaye, Max J., Kok, Niels F. M., Grotenhuis, Brechtje A., Aalbers, Arend G. J., Beets, Geerard L., Rijsemus, Charlotte, Maas, Monique, van Golen, Larissa W., Beets‐Tan, Regina G. H., and Lambregts, Doenja M. J.

Subjects
POSITRON emission tomography computed tomography, DIFFUSION magnetic resonance imaging, MAGNETIC resonance imaging, COLORECTAL cancer, POSITRON emission tomography
Abstract

Aim: The aim was to explore how findings of whole‐body MRI including diffusion‐weighted imaging (DW‐MRI) compared to the routine diagnostic workup with CT and/or 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT in patients with suspected recurrent colorectal cancer (CRC). Method: This was an exploratory retrospective analysis of 55 patients with a clinical suspicion of recurrent CRC who underwent DW‐MRI following CT and/or FDG‐PET/CT. Two readers in consensus interpreted all clinical imaging reports and converted each described lesion into a confidence score (1 = definitely benign to 5 = definitely malignant). DW‐MRI findings were compared to the most recent previous CT or PET/CT. Any discrepant or additional DW‐MRI findings were documented and compared with histology and/or clinical follow‐up (if available). Results: Whole‐body MRI including diffusion‐weighted imaging (DW‐MRI) resulted in discrepant/additional findings in 26/55 (47%) cases; 23/37 (62%) compared to previous CT and 3/18 (17%) compared to previous PET/CT. These included 10 cases where DW‐MRI converted previously inconclusive CT (n = 8) or PET/CT (n = 2) findings into a conclusive diagnosis, one where it contradicted a previous CT diagnosis of recurrence, five where DW‐MRI diagnosed recurrent disease not previously reported on CT and 10 cases where DW‐MRI detected additional lesions compared to CT (n = 9) or PET/CT (n = 1). Eighty‐eight per cent of cases with discrepant/additional findings concerned patients with recurrent/metachronous peritoneal metastases. In total, DW‐MRI resulted in 42 discrepant/additional lesions; the DW‐MRI diagnosis was correct in 76% of these lesions and incorrect (false positive) in 7%. In the remaining 17%, no standard of reference was available. Conclusions: This explorative study suggests that DW‐MRI may be of added value to patients with a clinical suspicion for recurrent CRC, in particular to identify patients with peritoneal metastases. DW‐MRI mainly has potential as a 'problem‐solver' in patients with inconclusive or negative findings on previous imaging (in particular CT) and to detect additional disease sites in patients already diagnosed with recurrent disease. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

44. Magnetic resonance imaging for clinical management of rectal cancer: Updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting

Author

Beets-Tan, Regina G. H., Lambregts, Doenja M. J., Maas, Monique, Bipat, Shandra, Barbaro, Brunella, Curvo-Semedo, Luís, Fenlon, Helen M., Gollub, Marc J., Gourtsoyianni, Sofia, Halligan, Steve, Hoeffel, Christine, Kim, Seung Ho, Laghi, Andrea, Maier, Andrea, Rafaelsen, Søren R., Stoker, Jaap, Taylor, Stuart A., Torkzad, Michael R., and Blomqvist, Lennart

Published
2018
Full Text
View/download PDF

45. Rectum

Author

Lambregts, Doenja M. J., primary and Beets-Tan, Regina G. H., additional

Published
2018
Full Text
View/download PDF

47. Defining near-complete response following (chemo)radiotherapy for rectal cancer: systematic review

Author

Custers, Petra A, Geubels, Barbara M, Beets, Geerard L, Lambregts, Doenja M J, van Leerdam, Monique E, van Triest, Baukelien, Maas, Monique, Custers, Petra A, Geubels, Barbara M, Beets, Geerard L, Lambregts, Doenja M J, van Leerdam, Monique E, van Triest, Baukelien, and Maas, Monique

Abstract

BACKGROUND: A uniform definition of a clinical near-complete response (near-CR) after neoadjuvant (chemo)radiotherapy for rectal cancer is lacking. A clear definition is necessary for uniformity in clinical practice and trial enrolment for organ-preserving treatments. This review aimed to provide an overview of the terminology, criteria, and features used in the literature to define a near-CR.METHODS: A systematic review was performed based on the PRISMA statement. PubMed and Embase were searched up to May 2021 to identify the terminology, criteria, and features used to define a near-CR after (chemo)radiotherapy for rectal cancer. Studies with no clear cut-off point between a cCR and near-CR, studies using Response Evaluation Criteria In Solid Tumours, and studies including only complete responders were excluded.RESULTS: A total of 1876 articles were found, of which 23 were included. Patients were managed by watchful waiting and/or additional local treatment in 11 and 17 of 23 studies respectively. Response evaluation included digital rectal examination (DRE) and/or endoscopy with MRI in 18 studies. The majority of studies used the term 'near-complete response'. In most studies, minor irregularities or a smooth induration with DRE and a small flat ulcer on endoscopy were considered to indicate a near-CR. On MRI, five studies used features (obvious downstaging with or without heterogeneous/irregular fibrosis on T2-weighted MRI or small spot of high signal on diffusion-weighted imaging), five studies used TNM criteria (ycT2), and four used magnetic resonance tumour regression grade (mrTRG) (mrTRG1-2/mrTRG2) to describe a near-CR.CONCLUSION: The terminology, criteria, and features used to describe a near-CR vary substantially, which can partly be explained by the different treatment strategies patients are selected for (watchful waiting or additional local treatment). A reproducible definition of near-CR is required.

Published
2023

48. Radiotherapy, atezolizumab, and bevacizumab in rectal cancers with the aim of organ preservation: The TARZAN study.

Author

Verschoor, Yara L., primary, Lambregts, Doenja M. J., additional, van den Berg, José, additional, Grotenhuis, Brechtje A., additional, Aalbers, Arend, additional, Van Triest, Baukelien, additional, Beets-Tan, Regina G.H., additional, van de Belt, Marieke, additional, Dokter, Simone, additional, Balduzzi, Sara, additional, Voest, Emile E., additional, Haanen, John B. A. G., additional, van Leerdam, Monique E., additional, Beets, Geerard, additional, and Chalabi, Myriam, additional

Published
2023
Full Text
View/download PDF

49. Organ Preservation in Rectal Cancer After Chemoradiation: Should We Extend the Observation Period in Patients with a Clinical Near-Complete Response?

Author

Hupkens, Britt J. P., Maas, Monique, Martens, Milou H., van der Sande, Marit E., Lambregts, Doenja M. J., Breukink, Stéphanie O., Melenhorst, Jarno, Houwers, Janneke B., Hoff, Christiaan, Sosef, Meindert N., Leijtens, Jeroen W. A., Berbee, Maaike, Beets-Tan, Regina G. H., and Beets, Geerard L.

Published
2017
Full Text
View/download PDF

50. Diffusion-weighted MRI to assess response to chemoradiotherapy in rectal cancer: main interpretation pitfalls and their use for teaching

Author

Lambregts, Doenja M. J., van Heeswijk, Miriam M., Delli Pizzi, Andrea, van Elderen, Saskia G. C., Andrade, Luisa, Peters, Nicky H. G. M., Kint, Peter A. M., Osinga-de Jong, Margreet, Bipat, Shandra, Ooms, Rik, Lahaye, Max J., Maas, Monique, Beets, Geerard L., Bakers, Frans C. H., and Beets-Tan, Regina G. H.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results