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5. Clinical Differences and Outcomes between Methamphetamine-associated and Idiopathic Pulmonary Arterial Hypertension in the Pulmonary Hypertension Association Registry.

Author

Kolaitis, Nicholas A, Zamanian, Roham T, de Jesus Perez, Vinicio A, Badesch, David B, Benza, Raymond L, Burger, Charles D, Chakinala, Murali M, Elwing, Jean M, Feldman, Jeremy, Lammi, Matthew R, Mathai, Stephen C, McConnell, John W, Presberg, Kenneth W, Robinson, Jeffrey C, Sager, Jeffrey, Shlobin, Oksana A, Simon, Marc A, Kawut, Steven M, Glidden, David V, Singer, Jonathan P, and De Marco, Teresa

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Clinical Research, Methamphetamine, Health Services, Cardiovascular, Good Health and Well Being, Familial Primary Pulmonary Hypertension, Humans, Hypertension, Pulmonary, Prospective Studies, Quality of Life, Registries, United States, Pulmonary Hypertension Association Registry, methamphetamine-associated pulmonary arterial hypertension, idiopathic pulmonary arterial hypertension, health-related quality of life, drug- and toxin-induced pulmonary arterial hypertension, Pulmonary Hypertension Association Registry Investigators, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Rationale: Single-center studies demonstrated that methamphetamine use is associated with pulmonary arterial hypertension (Meth-APAH). We used the Pulmonary Hypertension Association Registry to evaluate the national distribution of Meth-APAH and to compare its impact on patient-reported and clinical outcomes relative to idiopathic PAH.Objectives: To determine if patients with Meth-APAH differ from those with idiopathic PAH in demographics, regional distribution in the United States, hemodynamics, health-related quality of life, PAH-specific treatment, and health care use.Methods: The Pulmonary Hypertension Association Registry is a U.S.-based prospective cohort of patients new to care at a Pulmonary Hypertension Care Center. The registry collects baseline demographics, clinical parameters, and repeated measures of health-related quality of life, World Health Organization functional class, 6-minute walk distance, therapy, and health care use. Repeated measures of functional class, health-related quality of life, type of therapy, emergency department visits, and hospitalizations were compared using generalized estimating equations.Results: Of 541 participants included, 118 had Meth-APAH; 83% of Meth-APAH arose in the western United States. The Meth-APAH group was younger and had a poorer socioeconomic status and lower cardiac index than the idiopathic PAH group, despite no difference in mean pulmonary artery pressure or pulmonary vascular resistance. The Meth-APAH group had a more advanced functional class in longitudinal models (0.22 points greater; 95% confidence interval [CI], 0.07 to 0.37) and worse PAH-specific (emPHasis-10) health-related quality of life (-5.4; 95% CI, -8.1 to -2.8). There was no difference in dual combination therapy; however, participants with Meth-APAH were less likely to be initiated on triple therapy (odds ratio [OR], 0.43; 95% CI, 0.24 to 0.77) or parenteral therapy (OR, 0.10; 95% CI, 0.04 to 0.24). Participants with Meth-APAH were more likely to seek care in the emergency department (incidence rate ratio, 2.30; 95% CI, 1.71 to 3.11) and more likely to be hospitalized (incidence rate ratio, 1.42; 95% CI, 1.10 to 1.83).Conclusions: Meth-APAH represents a unique clinical phenotype of PAH, most common in the western United States. It accounts for a notable proportion of PAH in expert centers. Assessment for methamphetamine use is necessary in patients with PAH.

Published
2021

6. Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR).

Author

Min, Jeff, Feng, Rui, Badesch, David, Berman-Rosenzweig, Erika, Burger, Charles, Chakinala, Murali, De Marco, Teresa, Feldman, Jeremy, Hemnes, Anna, Horn, Evelyn M, Lammi, Matthew R, Mathai, Stephen, McConnell, John W, Presberg, Kenneth, Robinson, Jeffrey, Sager, Jeffrey, Shlobin, Oksana, Simon, Marc, Thenappan, Thenappan, Ventetuolo, Corey, Al-Naamani, Nadine, Allen, Roblee, Bartolome, Sonja, Benza, Raymond, Bull, Todd, Cadaret, Linda, Eggert, Michael, Elwing, Jean, Fineman, Jeffrey, Foley, Raymond, Ford, H James, Frantz, Robert, Hirsch, Russel, Grinnan, James, Ivy, D Dunbar, Kawut, Steven, Kennedy, Jamie, Klinger, James, Leary, Peter, Mazimba, Sula, Ramani, Gautam, Raina, Amresh, Runo, James, Swisher, John, Ryan, John, Varghese, Nidhy, White, R James, Williamson, Timothy, Yung, Delphine, Zamanian, Roham, and Zwicke, Dianne

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Nutrition, Clinical Research, Transplantation, Lung, Prevention, Obesity, Cardiovascular, pulmonary arterial hypertension, obesity, quality of life, hospitalization, survival analysis, PHAR Investigators, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleObesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood.ObjectivesTo assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH.MethodsWe performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status.Results767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p

Published
2021

9. Metoprolol for the Prevention of Acute Exacerbations of COPD

Author

Dransfield, Mark T, Voelker, Helen, Bhatt, Surya P, Brenner, Keith, Casaburi, Richard, Come, Carolyn E, Cooper, J Allen D, Criner, Gerard J, Curtis, Jeffrey L, Han, MeiLan K, Hatipoğlu, Umur, Helgeson, Erika S, Jain, Vipul V, Kalhan, Ravi, Kaminsky, David, Kaner, Robert, Kunisaki, Ken M, Lambert, Allison A, Lammi, Matthew R, Lindberg, Sarah, Make, Barry J, Martinez, Fernando J, McEvoy, Charlene, Panos, Ralph J, Reed, Robert M, Scanlon, Paul D, Sciurba, Frank C, Smith, Anthony, Sriram, Peruvemba S, Stringer, William W, Weingarten, Jeremy A, Wells, J Michael, Westfall, Elizabeth, Lazarus, Stephen C, and Connett, John E

Subjects
Clinical Trials and Supportive Activities, Chronic Obstructive Pulmonary Disease, Lung, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Respiratory, Adrenergic beta-1 Receptor Antagonists, Aged, Aged, 80 and over, Disease Progression, Female, Forced Expiratory Volume, Hospitalization, Humans, Kaplan-Meier Estimate, Male, Metoprolol, Middle Aged, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Treatment Failure, BLOCK COPD Trial Group, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundObservational studies suggest that beta-blockers may reduce the risk of exacerbations and death in patients with moderate or severe chronic obstructive pulmonary disease (COPD), but these findings have not been confirmed in randomized trials.MethodsIn this prospective, randomized trial, we assigned patients between the ages of 40 and 85 years who had COPD to receive either a beta-blocker (extended-release metoprolol) or placebo. All the patients had a clinical history of COPD, along with moderate airflow limitation and an increased risk of exacerbations, as evidenced by a history of exacerbations during the previous year or the prescribed use of supplemental oxygen. We excluded patients who were already taking a beta-blocker or who had an established indication for the use of such drugs. The primary end point was the time until the first exacerbation of COPD during the treatment period, which ranged from 336 to 350 days, depending on the adjusted dose of metoprolol.ResultsA total of 532 patients underwent randomization. The mean (±SD) age of the patients was 65.0±7.8 years; the mean forced expiratory volume in 1 second (FEV1) was 41.1±16.3% of the predicted value. The trial was stopped early because of futility with respect to the primary end point and safety concerns. There was no significant between-group difference in the median time until the first exacerbation, which was 202 days in the metoprolol group and 222 days in the placebo group (hazard ratio for metoprolol vs. placebo, 1.05; 95% confidence interval [CI], 0.84 to 1.32; P = 0.66). Metoprolol was associated with a higher risk of exacerbation leading to hospitalization (hazard ratio, 1.91; 95% CI, 1.29 to 2.83). The frequency of side effects that were possibly related to metoprolol was similar in the two groups, as was the overall rate of nonrespiratory serious adverse events. During the treatment period, there were 11 deaths in the metoprolol group and 5 in the placebo group.ConclusionsAmong patients with moderate or severe COPD who did not have an established indication for beta-blocker use, the time until the first COPD exacerbation was similar in the metoprolol group and the placebo group. Hospitalization for exacerbation was more common among the patients treated with metoprolol. (Funded by the Department of Defense; BLOCK COPD ClinicalTrials.gov number, NCT02587351.).

Published
2019

11. Age-related differences in hemodynamics and functional status in pulmonary arterial hypertension: Baseline results from the Pulmonary Hypertension Association Registry

Author

Allen, Roblee, Badesch, David, Bakshi, Sahil, Bartolome, Sonja, Bull, TM, Burger, Charles D, Cadaret, Linda M, Chakinala, Murali, De Marco, Teresa, Duncan, Michael, Eggert, Michael, Elwing, Jean M., Feldman, Jeremy, Fineman, Jeff, Foley, Raymond J., Ford, Hubert James, Frantz, Robert P, Grinnan, Daniel, Hemnes, Anna R, Hirsch, Russel, Horn, Evelyn M, Ivy, D Dunbar, Kawut, Steven M, Klinger, James R, Lammi, Matthew R., Leary, Peter J, Mathai, Stephen C, Mazimba, Sula, McConnell, John W., Parikh, Kishan S, Presberg, Kenneth W, Raina, Amresh, Ramani, Gautam, Robinson, Jeffrey C, Rosenzweig, Erika B, Runo, James R, Ryan, John J, Sager, Jeffrey S, Shlobin, Oksana A, Simon, Marc A, Swisher, John W, Thenappan, Thenappan, Varghese, Nidhy P, Ventetuolo, Corey E, White, R. James, Williamson, Timothy, Yung, Delphine, Zamanian, Roham T, Zwicke, Dianne L, DesJardin, Jacqueline T., Kolaitis, Nicholas A., Kime, Noah, Kronmal, Richard A., Benza, Raymond L., Presberg, Kenneth W., Sager, Jeffrey S., and Shlobin, Oksana A.

Published
2020
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15. Discordance Between Invasive and NonInvasive Oxygen Saturation in Critically Ill COVID-19 Patients.

Author

Fox, Thomas H., Mazalewski, William R., Tran, Hai S., Lindsey, Travis, Krishnan, Amita, Kantrow, Stephen P., Happel, Kyle I., Janz, David R., deBoisblanc, Bennett P., and Lammi, Matthew R.

Subjects
OXYGEN saturation, CRITICALLY ill patient care, COVID-19 testing, PULSE oximetry, RENAL replacement therapy
Abstract

Objectives: To investigate discordance in oxy-hemoglobin saturation measured both by pulse oximetry (SpO2) and arterial blood gas (ABG, SaO2) among critically ill coronavirus disease 2019 (COVID-19(+)) patients compared to COVID-19(-) patients. Methods: Paired SpO2 and SaO2 readings were collected retrospectively from consecutive adult admissions to four critical care units in the United States between March and May 2020. The primary outcome was the rate of discordance (|SaO2-SpO2|>4%) in COVID-19(+) versus COVID-19(-) patients. The odds each cohort could have been incorrectly categorized as having a PaO2/FiO2 above or below 150 by their SpO2: Fractional inhaled oxygen ratio (pulse oximetry-derived oxyhemoglobin saturation:fraction of inspired oxygen ratio [SF]) was examined. A multivariate regression analysis assessed confounding by clinical differences between cohorts including pH, body temperature, renal replacement therapy at time of blood draw, and self-identified race. Results: There were 263 patients (173 COVID-19(+)) included. The rate of saturation discordance between SaO2 and SpO2 in COVID-19(+) patients was higher than in COVID-19(-) patients (27.9% vs 16.7%, odds ratio [OR] 1.94, 95% confidence interval [CI]: 1.11 to 2.27). The average difference between SaO2 and SpO2 for COVID-19(+) patients was −1.24% (limits of agreement, −13.6 to 11.1) versus −0.11 [–10.3 to 10.1] for COVID-19(–) patients. COVID-19(+) patients had higher odds (OR: 2.61, 95% CI: 1.14-5.98) of having an SF that misclassified that patient as having a PaO2:FiO2 ratio above or below 150. There was not an association between discordance and the confounders of pH, body temperature, or renal replacement therapy at time of blood draw. After controlling for self-identified race, the association between COVID-19 status and discordance was lost. Conclusions: Pulse oximetry was discordant with ABG more often in critically ill COVID-19(+) than COVID-19(–) patients. However, these findings appear to be driven by racial differences between cohorts. [ABSTRACT FROM AUTHOR]

Published
2023
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18. sj-docx-1-jic-10.1177_08850666231186947 - Supplemental material for Discordance Between Invasive and NonInvasive Oxygen Saturation in Critically Ill COVID-19 Patients

Author

Fox, Thomas H., Mazalewski, William R., Tran, Hai S., Lindsey, Travis, Krishnan, Amita, Kantrow, Stephen P., Happel, Kyle I., Janz, David R., deBoisblanc, Bennett P., and Lammi, Matthew R.

Subjects
Aged Health Care, Emergency Medicine, Respiratory Diseases
Abstract

Supplemental material, sj-docx-1-jic-10.1177_08850666231186947 for Discordance Between Invasive and NonInvasive Oxygen Saturation in Critically Ill COVID-19 Patients by Thomas H. Fox, MD, William R. Mazalewski, DO, Hai S. Tran, MD, Travis Lindsey, MD, Amita Krishnan, MD, Stephen P. Kantrow, MD, Kyle I. Happel, MD, FCCP, David R. Janz, MD, Bennett P. deBoisblanc, MD, FACP, FCCP, FCCM, and Matthew R. Lammi, MD, MSCR in Journal of Intensive Care Medicine

Published
2023
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19. Pulmonary artery compliance in different forms of pulmonary hypertension.

Author

McCormick, Amber, Krishnan, Amita, Badesch, David, Benza, Raymond L., Bull, Todd M., De Marco, Teresa, Feldman, Jeremy, Hemnes, Anna R., Hirsch, Russel, Horn, Evelyn, Kennedy, Jaime, Mathai, Stephen C., McConnell, Wesley, Pugliese, Steven C., Sager, Jeffrey S., Shlobin, Oksana A., Simon, Marc A., and Lammi, Matthew R.

Subjects
PULMONARY hypertension, PULMONARY artery, VASCULAR remodeling, PULMONARY artery diseases
Published
2023
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21. World Health Organization (WHO) International Classification of Functioning, Disability and Health (ICF) Core Set Development for Interstitial Lung Disease

Author

Saketkoo, Lesley Ann, Escorpizo, Reuben, Varga, Janos, Keen, Kevin John, Fligelstone, Kim, Birring, Surinder S., Alexanderson, Helene, Pettersson, Henrik, Chaudhry, Humza Ahmad, Poole, Janet L., Regardt, Malin, LeSage, Daphne, Sarver, Catherine, Lanario, Joseph, Renzoni, Elisabetta, Scholand, Mary Beth, Lammi, Matthew R., Kowal-Bielecka, Otylia, Distler, Oliver, Frech, Tracy, Shapiro, Lee, Varju, Cecilia, Volkmann, Elizabeth R., Bernstein, Elana J., Drent, Marjolein, Obi, Ogugua Ndili, Patterson, Karen C., Russell, Anne-Marie, Faculteit FHML Centraal, and RS: FHML non-thematic output

Subjects
CTD-ILD, JOINT USE, REHABILITATION, Pharmacology, DOMAINS, fibrosis, INSTRUMENTS, PATIENT, VALIDATION, RHEUMATOID-ARTHRITIS, ICD-11, patient-reported outcomes, cough, QUALITY-OF-LIFE, UPDATE, IDIOPATHIC PULMONARY-FIBROSIS, Pharmacology (medical), connective tissue
Abstract

Background: The World Health Organization (WHO) introduced the International Classification of Functioning, Disability, and Health (ICF) as a scientific method of disability data collection comprised of >1,200 categories describing the spectrum of impairment types (functional, symptoms-based and anatomical) under the bio-psycho-social model with consideration of environmental and personal factors (pf). ICF Core Sets and ICF Checklists are streamlined disease-specific resources for clinical use, service provision, and for use in health economics and health policy. ICF can disclose strengths and weaknesses across multiple patient-reported outcome measures (PROMs) and help consolidate best-fitting question-items from multiple PROMs. Interstitial lung diseases (ILDs), are generally progressive, with restrictive physiology sometimes occurring in the context of multi-organ autoimmunity/inflammatory conditions such as connective tissue diseases (CTDs). In spite of significant associated morbidity and potential disability, ILD has yet to be linked to the ICF.Methods: Each instrument and their question-items within the consensus-recommended core sets for clinical trials in ILD were deconstructed to single concept units, and then linked per updated ICF linkage rules. Inter-linker agreement was established. Three additional subsequently validated measures were also included.Results: One-hundred-eleven ICF categories were identified for ten PROMs and three traditional objective measures that were amenable to ICF linkage. The proportion of agreement ranged from 0.79 (95% CI: 0.62, 0.91) to 0.93 (0.76, 0.99) with the overall proportion of inter-linker agreement being very high 0.86 (0.82, 0.89) for the initial instruments, with 94–100% for the three additional PROMs. Thirty-four new ‘Personal Factors’ emerged to capture disease-specific qualities not elsewhere described in ICF, e.g. ‘pf_embarrassed by cough’ or ‘pf_panic/afraid when can’t get a breath’.Conclusion: This first known effort in ICF linkage of ILD has provided important revelations on the current utility of the ICF in lung disease. Results have indicated areas for meaningful assessment of ICF descriptors for lung impairment. The mapping across PROMs provides insight into possibilities of developing more streamline and precise instrumentation. Finally, familiarity with the ICF in ILD may enable clinicians to experience a smoother transition with the imminent harmonization of ICD and ICF, ICD-11.

Published
2022

24. Organization of Outpatient Care After COVID-19 Hospitalization

Author

Valley, Thomas S., primary, Schutz, Amanda, additional, Peltan, Ithan D., additional, Vranas, Kelly C., additional, Mathews, Kusum S., additional, Jolley, Sarah E., additional, Palakshappa, Jessica A., additional, Hough, Catherine L., additional, Steingrub, Jay S., additional, Tidswell, Mark A., additional, Kozikowski, Lori-Ann, additional, Kardos, Cynthia, additional, DeSouza, Lesley, additional, Baron, Rebecca M., additional, Pinilla-Vera, Mayra, additional, Rubins, David M., additional, Arciniegas, Antonio, additional, Riker, Richard, additional, Lord, Christine, additional, Elie, Marie-Carmelle, additional, Talmor, Daniel, additional, Shapiro, Nathan, additional, Banner-Goodspeed, Valerie, additional, Hibbert, Kathryn A., additional, Brait, Kelsey, additional, Pulido, Natalie, additional, Jones, Alan, additional, Galbraith, James, additional, Nandi, Utsav, additional, Peacock, Rebekah, additional, Davis, Jenna, additional, Prekker, Matthew, additional, Puskarich, Michael, additional, Jones, Seth, additional, Roerhl, Anne, additional, Hendrickson, Audrey, additional, Matthay, Michael, additional, Kangelaris, Kirsten, additional, Liu, Kathleen, additional, Yee, Kimberly, additional, Zhuo, Hanjing, additional, Hendey, Gregory, additional, Chang, Steven, additional, Qadir, Nida, additional, Tam, Andrea, additional, Beutler, Rebecca, additional, Agarwal, Trisha, additional, Levitt, Joseph, additional, Wilson, Jennifer G., additional, Rogers, Angela, additional, Roque, Jonasel, additional, Vojnik, Rosemary, additional, Albertson, Timothy E., additional, Chenoweth, James A., additional, Adams, Jason Y., additional, Morrissey, Brian M., additional, Pearson, Skyler J., additional, Almasri, Eyad, additional, Hughes, Alyssa, additional, Moss, Marc, additional, Ginde, Adit, additional, McKeehan, Jeffrey, additional, Finck, Lani, additional, Howell, Michelle, additional, Higgins, Carrie, additional, Haukoos, Jason, additional, Gravitz, Stephanie, additional, Lyle, Carolynn, additional, Douglas, Ivor S., additional, Hiller, Terra, additional, Goold, Audrey, additional, Finigan, James, additional, Hyzy, Robert, additional, Park, Pauline, additional, Sjoding, Michael, additional, Kay, Stephen, additional, Nelson, Kristine, additional, McDonough, Kelli, additional, Jayaprakash, Namita, additional, Rivers, Emanuel P., additional, Swiderek, Jennifer, additional, Gill, Jasreen Kaur, additional, Day, Jacqueline, additional, Sherwin, Robert, additional, Wooden, James, additional, Mazzoco, Thomas, additional, Gong, Michelle Ng, additional, Aboodi, Michael, additional, Asghar, Ayesha, additional, Amosu, Omowunmi, additional, Tzehaie, Hiwet, additional, Hope, Aluko A., additional, Chen, Jen-Ting, additional, Nair, Rahul, additional, Lopez, Brenda, additional, Offor, Obiageli, additional, Mosier, Jarrod M., additional, Hypes, Cameron D., additional, Salvagio, Elizabeth, additional, Bime, Christian, additional, Cristan, Elaine, additional, Richardson, Lynne D., additional, Goel, Neha, additional, Maher, Patrick, additional, Acquah, Samuel, additional, Cardone, Donald, additional, Oldenburg, Gary, additional, Dunn, Andrew, additional, Hite, Duncan, additional, Hudock, Kristin, additional, Arroyo, Jose Gomez, additional, Roads, Tammy, additional, Duggal, Abhijit, additional, Mireles-Cabodevila, Eduardo, additional, Robinson, Bryce R.H., additional, Johnson, Nicholas J., additional, Gundel, Stephanie, additional, Evans, Laura, additional, O'Mahony, D. Shane, additional, Wallick, Julie A., additional, Pedraza, Isabel, additional, Khan, Akram, additional, Krol, Olivia, additional, Jouzestani, Milad Karami, additional, Vranas, Kelly, additional, Yealy, Donald M., additional, Angus, Derek C., additional, Weissman, Alexandra, additional, Huang, David T., additional, Boeltz-Skrtich, Aimee, additional, Moore, Steven, additional, Isenberg, Derek, additional, Files, D. Clark, additional, Miller, Chadwick, additional, Gibbs, Kevin, additional, Flores, Lori, additional, LaRose, Mary, additional, Koehler, Lauren, additional, Landreth, Leigha, additional, Morris, Peter, additional, Cassity, Evan, additional, Sturgill, Jamie, additional, Mayer, Kirby, additional, Montgomery-Yates, Ashley, additional, de Wit, Marjolein, additional, Mason, Jessica, additional, Goodwin, Andrew, additional, Grady, Abigail, additional, Burch, Patterson, additional, Enfield, Kyle B., additional, Sturek, Jeffrey M., additional, Marshall, Mary, additional, Bledsoe, Joseph R., additional, Brown, Samuel M., additional, Grissom, Colin K., additional, Armbruster, Brent, additional, Harris, Estelle, additional, Eppensteiner, John, additional, Hall, Bria Johnston, additional, Hall, Grace L., additional, McGowan, Lauren, additional, Bouffler, Andrew, additional, Walker, Erica, additional, Francis, Samuel, additional, Porter, Tedra, additional, deBoisblanc, Bennett P., additional, Lammi, Matthew R., additional, Janz, David R., additional, Lauto, Paula, additional, Romaine, Connie, additional, Sandi, Marie, additional, Rice, Todd W., additional, Self, Wesley H., additional, Ringwood, Nancy, additional, Nagrebetsky, Alexander, additional, Fitzgerald, Laura, additional, Brower, Roy G., additional, Reineck, Lora A., additional, Aggarwal, Neil R., additional, and Bienstock, Karen, additional

Published
2022
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29. Air current applied to the face improves exercise performance in patients with COPD

Author

Marchetti, Nathaniel, Lammi, Matthew R., Travaline, John M., Ciccolella, David, Civic, Brian, and Criner, Gerard J.

Subjects
Exercise -- Research -- Health aspects, Lung diseases, Obstructive -- Research -- Care and treatment -- Patient outcomes -- Development and progression, Health
Abstract

Purpose Improving dyspnea and exercise performance are goals of COPD therapy. We tested the hypothesis that air current applied to the face would lessen dyspnea and improve exercise performance in moderate-severe COPD patients. Methods We recruited 10 COPD patients (5 men, age 62 ± 6 years, [FEV.sub.1] 0.93 ± 0.11 L (34 ± 3 % predicted), TLC 107 ± 6 %, RV 172 ± 18 %) naive to the study hypothesis. Each patient was randomized in a crossover fashion to lower extremity ergometry at constant submaximal workload with a 12-diameter fan directed at the patients face or exposed leg. Each patients' studies were separated by at least 1 week. Inspiratory capacity and Borg dyspnea score were measured every 2 min and at maximal exercise. Results Total exercise time was longer when the fan was directed to the face (14.3 ± 12 vs. 9.4 ± 7.6 min, face vs. leg, respectively, p = 0.03). Inspiratory capacity tended to be greater with the fan directed to the face (1.4 (0.6-3.25) vs. 1.26 (0.56-2.89) L, p = 0.06). There was a reduction in dynamic hyperinflation, as reflected by higher IRV area in the fan on face group (553 ± 562 a.u. vs. 328 ± 319 a.u., p = 0.047). There was a significant improvement in the Borg dyspnea score at maximal exercise (5.0 (0-10) vs. 6.5 (0-10), p = 0.03), despite exercising for 34 % longer with the fan directed to the face. Conclusions Air current applied to the face improves exercise performance in COPD. Possible mechanisms include an alteration in breathing pattern that diminishes development of dynamic hyperinflation or to a change in perception of breathlessness. Keywords COPD * Dynamic hyperinflation * Emphysema * Exercise physiology, Introduction Chronic obstructive pulmonary disease (COPD) is the 3rd leading cause of death in the United States and further increases in the prevalence and mortality is expected in the coming [...]

Published
2015
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31. Organization of Outpatient Care After COVID-19 Hospitalization

Author

Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Lesley, Baron, Rebecca M., Pinilla-Vera, Mayra, Rubins, David M., Arciniegas, Antonio, Riker, Richard, Lord, Christine, Elie, Marie-Carmelle, Talmor, Daniel, Shapiro, Nathan, Banner-Goodspeed, Valerie, Hibbert, Kathryn A., Brait, Kelsey, Pulido, Natalie, Jones, Alan, Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Davis, Jenna, Prekker, Matthew, Puskarich, Michael, Jones, Seth, Roerhl, Anne, Hendrickson, Audrey, Matthay, Michael, Kangelaris, Kirsten, Liu, Kathleen, Yee, Kimberly, Zhuo, Hanjing, Hendey, Gregory, Chang, Steven, Qadir, Nida, Tam, Andrea, Beutler, Rebecca, Agarwal, Trisha, Levitt, Joseph, Wilson, Jennifer G., Rogers, Angela, Roque, Jonasel, Vojnik, Rosemary, Albertson, Timothy E., Chenoweth, James A., Adams, Jason Y., Morrissey, Brian M., Pearson, Skyler J., Almasri, Eyad, Hughes, Alyssa, Moss, Marc, Ginde, Adit, McKeehan, Jeffrey, Finck, Lani, Howell, Michelle, Higgins, Carrie, Haukoos, Jason, Gravitz, Stephanie, Lyle, Carolynn, Douglas, Ivor S., Hiller, Terra, Goold, Audrey, Finigan, James, Hyzy, Robert, Park, Pauline, Sjoding, Michael, Kay, Stephen, Nelson, Kristine, McDonough, Kelli, Jayaprakash, Namita, Rivers, Emanuel P., Swiderek, Jennifer, Gill, Jasreen Kaur, Day, Jacqueline, Sherwin, Robert, Wooden, James, Mazzoco, Thomas, Gong, Michelle Ng, Aboodi, Michael, Asghar, Ayesha, Amosu, Omowunmi, Tzehaie, Hiwet, Hope, Aluko A., Chen, Jen-Ting, Nair, Rahul, Lopez, Brenda, Offor, Obiageli, Mosier, Jarrod M., Hypes, Cameron D., Salvagio, Elizabeth, Bime, Christian, Cristan, Elaine, Richardson, Lynne D., Mathews, Kusum S., Goel, Neha, Maher, Patrick, Acquah, Samuel, Cardone, Donald, Oldenburg, Gary, Dunn, Andrew, Hite, Duncan, Hudock, Kristin, Arroyo, Jose Gomez, Roads, Tammy, Duggal, Abhijit, Mireles-Cabodevila, Eduardo, Robinson, Bryce R.H., Johnson, Nicholas J., Gundel, Stephanie, Evans, Laura, O'Mahony, D. Shane, Wallick, Julie A., Pedraza, Isabel, Hough, Catherine L., Khan, Akram, Krol, Olivia, Jouzestani, Milad Karami, Vranas, Kelly, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra, Huang, David T., Boeltz-Skrtich, Aimee, Moore, Steven, Isenberg, Derek, Files, D. Clark, Miller, Chadwick, Gibbs, Kevin, Flores, Lori, LaRose, Mary, Koehler, Lauren, Landreth, Leigha, Morris, Peter, Cassity, Evan, Sturgill, Jamie, Mayer, Kirby, Montgomery-Yates, Ashley, de Wit, Marjolein, Mason, Jessica, Goodwin, Andrew, Grady, Abigail, Burch, Patterson, Enfield, Kyle B., Sturek, Jeffrey M., Marshall, Mary, Bledsoe, Joseph R., Brown, Samuel M., Peltan, Ithan D., Grissom, Colin K., Armbruster, Brent, Harris, Estelle, Eppensteiner, John, Hall, Bria Johnston, Hall, Grace L., McGowan, Lauren, Bouffler, Andrew, Walker, Erica, Francis, Samuel, Porter, Tedra, deBoisblanc, Bennett P., Lammi, Matthew R., Janz, David R., Lauto, Paula, Romaine, Connie, Sandi, Marie, Rice, Todd W., Self, Wesley H., Ringwood, Nancy, Nagrebetsky, Alexander, Fitzgerald, Laura, Brower, Roy G., Reineck, Lora A., Aggarwal, Neil R., Bienstock, Karen, Valley, Thomas S., Schutz, Amanda, Vranas, Kelly C., Jolley, Sarah E., and Palakshappa, Jessica A.

Published
2022
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32. sj-docx-1-jpx-10.1177_23743735221075556 - Supplemental material for Sarcoidosis Illuminations on Living During COVID-19: Patient Experiences of Diagnosis, Management, and Survival Before and During the Pandemic*

Author

Saketkoo, Lesley Ann, Jensen, Kelly, Nikoletou, Dimitra, Newton, Jacqui J., Rivera, Frank J., Howie, Mike, Reese, Rodney K., Goodman, Melanie, Hart, Patricia B., Bembry, Whitney, Russell, Adam, Lian, Isabelle, Lammi, Matthew R., Scholand, Mary Beth, and Russell, Anne-Marie

Subjects
111708 Health and Community Services, Medicine, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-jpx-10.1177_23743735221075556 for Sarcoidosis Illuminations on Living During COVID-19: Patient Experiences of Diagnosis, Management, and Survival Before and During the Pandemic* by Lesley Ann Saketkoo LA, MD, MPH, Kelly Jensen, MD, MPH, Dimitra Nikoletou, PhD, MSc, Jacqui J. Newton, Frank J. Rivera, BA, Mike Howie, Rodney K. Reese, Melanie Goodman, BS, Patricia B. Hart, MBA, Whitney Bembry, MD, Adam Russell, BA, Isabelle Lian, MS, Matthew R. Lammi, MD, MSCR, Mary Beth Scholand MB, MD, and Anne-Marie Russell AM, PhD, APRN, ATSF in Journal of Patient Experience

Published
2022
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36. Sarcoidosis Illuminations on Living During COVID-19: Patient Experiences of Diagnosis, Management, and Survival Before and During the Pandemic

Author

Saketkoo, Lesley Ann, primary, Jensen, Kelly, additional, Nikoletou, Dimitra, additional, Newton, Jacqui J., additional, Rivera, Frank J., additional, Howie, Mike, additional, Reese, Rodney K., additional, Goodman, Melanie, additional, Hart, Patricia B., additional, Bembry, Whitney, additional, Russell, Adam, additional, Lian, Isabelle, additional, Lammi, Matthew R., additional, Scholand, Mary Beth, additional, and Russell, Anne-Marie, additional

Published
2022
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38. Exercise as a multi-modal disease-modifying medicine in systemic sclerosis: An introduction by The Global Fellowship on Rehabilitation and Exercise in Systemic Sclerosis (G-FoRSS)

Author

Pettersson, Henrik, primary, Alexanderson, Helene, additional, Poole, Janet L., additional, Varga, Janos, additional, Regardt, Malin, additional, Russell, Anne-Marie, additional, Salam, Yasser, additional, Jensen, Kelly, additional, Mansour, Jennifer, additional, Frech, Tracy, additional, Feghali-Bostwick, Carol, additional, Varjú, Cecília, additional, Baldwin, Nancy, additional, Heenan, Matty, additional, Fligelstone, Kim, additional, Holmner, Monica, additional, Lammi, Matthew R., additional, Scholand, Mary Beth, additional, Shapiro, Lee, additional, Volkmann, Elizabeth R., additional, and Saketkoo, Lesley Ann, additional

Published
2021
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39. A comprehensive framework for navigating patient care in systemic sclerosis: A global response to the need for improving the practice of diagnostic and preventive strategies in SSc

Author

Saketkoo, Lesley Ann, primary, Frech, Tracy, additional, Varjú, Cecília, additional, Domsic, Robyn, additional, Farrell, Jessica, additional, Gordon, Jessica K., additional, Mihai, Carina, additional, Sandorfi, Nora, additional, Shapiro, Lee, additional, Poole, Janet, additional, Volkmann, Elizabeth R., additional, Lammi, Monika, additional, McAnally, Kendra, additional, Alexanderson, Helene, additional, Pettersson, Henrik, additional, Hant, Faye, additional, Kuwana, Masataka, additional, Shah, Ami A., additional, Smith, Vanessa, additional, Hsu, Vivien, additional, Kowal-Bielecka, Otylia, additional, Assassi, Shervin, additional, Cutolo, Maurizio, additional, Kayser, Cristiane, additional, Shanmugam, Victoria K., additional, Vonk, Madelon C., additional, Fligelstone, Kim, additional, Baldwin, Nancy, additional, Connolly, Kerri, additional, Ronnow, Anneliese, additional, Toth, Beata, additional, Suave, Maureen, additional, Farrington, Sue, additional, Bernstein, Elana J., additional, Crofford, Leslie J., additional, Czirják, László, additional, Jensen, Kelly, additional, Hinchclif, Monique, additional, Hudson, Marie, additional, Lammi, Matthew R., additional, Mansour, Jennifer, additional, Morgan, Nadia D., additional, Mendoza, Fabian, additional, Nikpour, Mandana, additional, Pauling, John, additional, Riemekasten, Gabriela, additional, Russell, Anne-Marie, additional, Scholand, Mary Beth, additional, Seigart, Elise, additional, Rodriguez-Reyna, Tatiana Sofia, additional, Hummers, Laura, additional, Walker, Ulrich, additional, and Steen, Virginia, additional

Published
2021
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40. Association Between Initial Oral Therapy and Outcomes in Systemic Sclerosis–Related Pulmonary Arterial Hypertension

Author

Lammi, Matthew R., Mathai, Stephen C., Saketkoo, Lesley Ann, Domsic, Robyn T., Bojanowski, Christine, Furst, Daniel E., Steen, Virginia D., Hinchcliff, Monique, Varga, John, Frech, Tracy, Hummers, Laura, Hsu, Vivien, Chung, Lorinda, Csuka, Mary Ellen, Silver, Rick, Bolster, Marcy, Fischer, Aryeh, Molitor, Jerry, Preston, Ioana, Gordon, Jessica, Khanna, Dinesh, Alkassab, Firas, Horn, Evelyn, and Gomberg-Maitland, Mardi

Published
2016
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43. Health Related Quality of Life and Hospitalizations In Chronic Thromboembolic Pulmonary Hypertension Versus Idiopathic Pulmonary Arterial Hypertension: An Analysis from the Pulmonary Hypertension Association (PHAR)

Author

Minhas, Jasleen, primary, Narasimmal, Sai Prasanna, additional, Bull, Todd, additional, De Marco, Teresa, additional, McConnell, John Wesley, additional, Lammi, Matthew R., additional, Thenappan, Thenappan, additional, Feldman, Jeremy, additional, Sager, Jeffrey, additional, Badesch, David, additional, Ryan, John J., additional, Grinnan, Daniel, additional, Zwicke, Dianne, additional, Horn, Evelyn, additional, Elwing, Jean M., additional, Moss, John E., additional, Eggert, Michael, additional, Shlobin, Oksana A., additional, Frantz, Robert, additional, Bartolome, Sonja, additional, Mathai, Stephen C., additional, Mazimba, Sula, additional, Pugliese, Steven, additional, and Al-Naamani, Nadine, additional

Published
2021
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44. sj-pdf-1-pul-10.1177_20458940211020913 - Supplemental material for Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry

Author

DuBrock, Hilary M., Burger, Charles D., Bartolome, Sonja D., Feldman, Jeremy P., Ivy, D. Dunbar, Rosenzweig, Erika B., Sager, Jeffrey S., Presberg, Kenneth W., Mathai, Stephen C., Lammi, Matthew R., Klinger, James R., Eggert, Michael, De Marco, Teresa, Elwing, Jean M., Badesch, David, Bull, Todd M., Cadaret, Linda M., Ramani, Gautam, Thenappan, Thenappan, Ford, H. James, Al-Naamani, Nadine, Simon, Marc A., Mazimba, Sula, Runo, James R., Chakinala, Murali, Horn, Evelyn M., Ryan, John J., Frantz, Robert P., and Krowka, Michael J.

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, Cardiology
Abstract

Supplemental material, sj-pdf-1-pul-10.1177_20458940211020913 for Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry by Hilary M. DuBrock, Charles D. Burger, Sonja D. Bartolome, Jeremy P. Feldman, D. Dunbar Ivy, Erika B. Rosenzweig, Jeffrey S. Sager, Kenneth W. Presberg, Stephen C. Mathai, Matthew R. Lammi, James R. Klinger, Michael Eggert, Teresa De Marco, Jean M. Elwing, David Badesch, Todd M. Bull, Linda M. Cadaret, Gautam Ramani, Thenappan Thenappan, H. James Ford, Nadine Al-Naamani, Marc A. Simon, Sula Mazimba, James R. Runo, Murali Chakinala, Evelyn M. Horn, John J. Ryan, Robert P. Frantz and Michael J. Krowka; on behalf of the PHAR Investigators in Pulmonary Circulation

Published
2021
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46. Acute effect of inhaled iloprost on exercise dynamic hyperinflation in COPD patients: A randomized crossover study

Author

Lammi, Matthew R., primary, Ghonim, Mohamed A., additional, Johnson, Jessica, additional, D'Aquin, Johnny, additional, Zamjahn, John B., additional, Pellett, Andy, additional, Okpechi, Samuel C., additional, Romaine, Connie, additional, Pyakurel, Kusma, additional, Luu, Hahn H., additional, Shellito, Judd E., additional, Boulares, A. Hamid, additional, and deBoisblanc, Bennett P., additional

Published
2021
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47. Obesity in Pulmonary Arterial Hypertension. The Pulmonary Hypertension Association Registry

Author

Min, Jeff, primary, Feng, Rui, additional, Badesch, David, additional, Berman-Rosenzweig, Erika, additional, Burger, Charles, additional, Chakinala, Murali, additional, De Marco, Teresa, additional, Feldman, Jeremy, additional, Hemnes, Anna, additional, Horn, Evelyn M., additional, Lammi, Matthew R., additional, Mathai, Stephen, additional, McConnell, John W., additional, Presberg, Kenneth, additional, Robinson, Jeffrey, additional, Sager, Jeffrey, additional, Shlobin, Oksana, additional, Simon, Marc, additional, Thenappan, Thenappan, additional, Ventetuolo, Corey, additional, Al-Naamani, Nadine, additional, Allen, Roblee, additional, Bartolome, Sonja, additional, Benza, Raymond, additional, Bull, Todd, additional, Cadaret, Linda, additional, Eggert, Michael, additional, Elwing, Jean, additional, Fineman, Jeffrey, additional, Foley, Raymond, additional, Ford, H. James, additional, Frantz, Robert, additional, Hirsch, Russel, additional, Grinnan, James, additional, Ivy, D. Dunbar, additional, Kawut, Steven, additional, Kennedy, Jamie, additional, Klinger, James, additional, Leary, Peter, additional, Mazimba, Sula, additional, Ramani, Gautam, additional, Raina, Amresh, additional, Runo, James, additional, Swisher, John, additional, Ryan, John, additional, Varghese, Nidhy, additional, White, R. James, additional, Williamson, Timothy, additional, Yung, Delphine, additional, Zamanian, Roham, additional, and Zwicke, Dianne, additional

Published
2021
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48. Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR)

Author

Min, Jeff, Feng, Rui, Badesch, David, Berman-Rosenzweig, Erika, Burger, Charles, Chakinala, Murali, De Marco, Teresa, Feldman, Jeremy, Hemnes, Anna, Horn, Evelyn M, Lammi, Matthew R, Mathai, Stephen, McConnell, John W, Presberg, Kenneth, Robinson, Jeffrey, Sager, Jeffrey, Shlobin, Oksana A, Simon, Marc, Thenappan, Thenappan, Ventetuolo, Corey, Al-Naamani, Nadine, and PHAR Investigators

Subjects
PHAR Investigators, Transplantation, obesity, quality of life, Clinical Research, Prevention, pulmonary arterial hypertension, Cardiovascular, Lung, Nutrition, hospitalization, survival analysis
Abstract

RationaleObesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood.ObjectivesTo assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH.MethodsWe performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status.Results767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p

Published
2020

49. ATS Core Curriculum 2020. Adult Pulmonary Medicine

Author

Channick, Colleen L., primary, Garrison, Garth, additional, Huie, Tristan J., additional, Narewski, Erin, additional, Caplan-Shaw, Caralee, additional, Cho, Josalyn, additional, Rafeq, Samaan, additional, Alalawi, Raed, additional, Alashram, Rami, additional, Bailey, Kristina L., additional, Carmona, Eva M., additional, Habib, Naomi, additional, Kapolka, Rebecca, additional, Krishnan, Amita, additional, Lammi, Matthew R., additional, Peck, Tyler, additional, Pennington, Kelly M., additional, Rali, Parth, additional, Small, Bronwyn L., additional, Swenson, Colin, additional, Witkin, Alison, additional, and Hayes, Margaret M., additional

Published
2020
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