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1. Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.

Author

Lamonic, Janine M., Wulan Deng, Kadauke, Stephan, Campbell, Amy E., Gamsjaeger, Roland, Wang, Hongxin, Yong Cheng, Billin, Andrew N., Hardison, Ross C., Mackay, Joel P., and Blobel, Gerd A.

Subjects
*ERYTHROCYTE membranes, *CHROMATIN, *NUCLEOPROTEINS, *ACETYLATION, *GENE expression, *GENETIC regulation
Abstract

The article discusses the association of Bromodomain protein Brd3 with the acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Study shows that both Brd3 and GATA1 interact physically in a manner that is dependent on acetylation. It points out that this interaction is necessary for the occupancy of proteins on chromatin and the normal red cell-specific gene expression.

Published
2011
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