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1,414 results on '"Lanctôt, Krista L."'

1. Neurophysiological and other features of working memory in older adults at risk for dementia

Author

Patterson, Rachel A., Brooks, Heather, Mirjalili, Mina, Rashidi-Ranjbar, Neda, Zomorrodi, Reza, Blumberger, Daniel M., Fischer, Corinne E., Flint, Alastair J., Graff-Guerrero, Ariel, Herrmann, Nathan, Kennedy, James L., Kumar, Sanjeev, Lanctôt, Krista L., Mah, Linda, Mulsant, Benoit H., Pollock, Bruce G., Voineskos, Aristotle N., Wang, Wei, and Rajji, Tarek K.

Published
2024
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3. Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke

Author

Yu, Di, Liang, Nuanyi, Zebarth, Julia, Shen, Qing, Ozzoude, Miracle, Goubran, Maged, Rabin, Jennifer S, Ramirez, Joel, Scott, Christopher JM, Gao, Fuqiang, Bartha, Robert, Symons, Sean, Haddad, Seyyed Mohammad Hassan, Berezuk, Courtney, Tan, Brian, Kwan, Donna, Hegele, Robert A, Dilliott, Allison A, Nanayakkara, Nuwan D, Binns, Malcolm A, Beaton, Derek, Arnott, Stephen R, Lawrence‐Dewar, Jane M, Hassan, Ayman, Dowlatshahi, Dar, Mandzia, Jennifer, Sahlas, Demetrios, Casaubon, Leanne, Saposnik, Gustavo, Otoki, Yurika, Lanctôt, Krista L, Masellis, Mario, Black, Sandra E, Swartz, Richard H, Taha, Ameer Y, Swardfager, Walter, Rashkovan, Natalie, Abrahao, Agessandro, Zinman, Lorne, Bonnick, Alisia, Scott, Christopher, Holmes, Melissa, Adamo, Sabrina, Freedman, Morris, Zamyadi, Mojdeh, Arnott, Stephen, Binns, Malcolm, Raamana, Pradeep, Strother, Stephen, Sunderland, Kelly, Theyers, Athena, Uthirakumaran, Abiramy, Levine, Brian, Troyer, Angela, Strong, Michael, Kleinstiver, Peter, Borrie, Michael, Finger, Elizabeth, Shoesmith, Christen, Faria, Frederico, Montero‐Odasso, Manuel, Sarquis‐Adamson, Yanina, Black, Alanna, Dilliott, Allison Ann, Hegele, Rob, Robinson, John, Farhan, Sali, Bartha, Rob, Haddad, Hassan, Nanayakkara, Nuwan, Zou, Guangyong, Pasternak, Stephen, Orange, JB, Roberts, Angela, Jog, Mandar, Seitz, Dallas, Brien, Don, Chen, Ying, Coe, Brian, Munoz, Doug, McLaughlin, Paula, Peltsch, Alicia, Bronskill, Susan, Lou, Wendy, Kumar, Sanjeev, Pollock, Bruce, Rajji, Tarek, Tang‐Wai, David, and Tartaglia, Carmela

Subjects
Biomedical Imaging, Stroke, Brain Disorders, Neurosciences, Humans, Linoleic Acid, Oxylipins, Epoxide Hydrolases, Cerebral Small Vessel Diseases, Magnetic Resonance Imaging, Atrophy, Water, lacunar stroke, oxylipin, small vessel disease, soluble epoxide hydrolase, white matter hyperintensity, ONDRI Investigators [Link], Cardiorespiratory Medicine and Haematology
Abstract

Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic acid [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic acid [EpOME] and 9(10)-EpOME); however, the relationship has not yet been examined in stroke. Methods and Results Participants with mild to moderate small vessel stroke or large vessel stroke were selected based on clinical and imaging criteria. Metabolites were quantified by ultra-high-performance liquid chromatography-mass spectrometry. Volumes of stroke, lacunes, white matter hyperintensities, magnetic resonance imaging visible perivascular spaces, and free water diffusion were quantified from structural and diffusion magnetic resonance imaging (3 Tesla). Adjusted linear regression models were used for analysis. Compared with participants with large vessel stroke (n=30), participants with small vessel stroke (n=50) had a higher 12,13-DiHOME/12(13)-EpOME ratio (β=0.251, P=0.023). The 12,13-DiHOME/12(13)-EpOME ratio was associated with more lacunes (β=0.266, P=0.028) but not with large vessel stroke volumes. Ratios of 12,13-DiHOME/12(13)-EpOME and 9,10-DiHOME/9(10)-EpOME were associated with greater volumes of white matter hyperintensities (β=0.364, P

Published
2023

8. Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression

Author

Poulin, Joshua M., Bigford, Gregory E., Lanctôt, Krista L., Giacobbe, Peter, Schaffer, Ayal, Sinyor, Mark, Rabin, Jennifer S., Masellis, Mario, Singnurkar, Amit, Pople, Christopher B., Lipsman, Nir, Husain, Muhammad I., Rosenblat, Joshua D., Cao, Xingshan, MacIntosh, Bradley J., and Nestor, Sean M.

Published
2024
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9. Cognitive function based on theta-gamma coupling vs. clinical diagnosis in older adults with mild cognitive impairment with or without major depressive disorder

Author

Brooks, Heather, Wang, Wei, Zomorrodi, Reza, Blumberger, Daniel M., Bowie, Christopher R., Daskalakis, Zafiris J., Fischer, Corinne E., Flint, Alastair J., Herrmann, Nathan, Kumar, Sanjeev, Lanctôt, Krista L., Mah, Linda, Mulsant, Benoit H., Pollock, Bruce G., Voineskos, Aristotle N., and Rajji, Tarek K.

Published
2024
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11. Adverse effects of methylphenidate for apathy in patients with Alzheimer's disease (ADMET2 trial)

Author

Zeng, Lijuan, primary, Perin, Jamie, additional, Gross, Alden L., additional, Shade, David, additional, Lanctôt, Krista L., additional, Lerner, Alan J., additional, Mintzer, Jacobo E., additional, Brawman‐Mintzer, Olga, additional, Padala, Prasad R., additional, van Dyck, Christopher H., additional, Porsteinsson, Anton P., additional, Craft, Suzanne, additional, Levey, Allan, additional, Herrmann, Nathan, additional, and Rosenberg, Paul B., additional

Published
2024
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15. Revisiting Criteria for Psychosis in Alzheimer's Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research.

Author

Fischer, Corinne E, Ismail, Zahinoor, Youakim, James M, Creese, Byron, Kumar, Sanjeev, Nuñez, Nicolas, Ryan Darby, R, Di Vita, Antonella, D’Antonio, Fabrizia, de Lena, Carlo, McGeown, William J, Ramit, Ravona, Rasmussen, Jill, Bell, Joanne, Wang, Huali, Bruneau, Marie-Andrée, Panegyres, Peter K, Lanctôt, Krista L, Agüera-Ortiz, Luis, Lyketsos, Constantine, Cummings, Jeffrey, Jeste, Dilip V, Sano, Mary, Devanand, DP, Sweet, Robert A, and Ballard, Clive

Subjects
Biological Psychology, Psychology, Acquired Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Neurosciences, Brain Disorders, Mental Health, Neurodegenerative, Aging, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Alzheimer Disease, Biomarkers, Disease Progression, Humans, Phenotype, Psychotic Disorders, Alzheimer's disease, criteria, delusions, hallucinations, mild cognitive impairment, psychosis, Alzheimer’s disease, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

BackgroundPsychotic symptoms are common in Alzheimer's disease (AD) and related neurodegenerative disorders and are associated with more rapid disease progression and increased mortality. It is unclear to what degree existing criteria are utilized in clinical research and practice.ObjectiveTo establish research criteria for the diagnosis of psychosis in AD.MethodsThe International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) psychosis subgroup reviewed existing criteria for psychosis in AD and related dementias. Through a series of in person and on-line meetings, a priority checklist was devised to capture features necessary for current research and clinical needs. PubMed, Medline and other relevant databases were searched for relevant criteria.ResultsConsensus identified three sets of criteria suitable for review including those of Jeste and Finkel, Lyketsos, and the Diagnostic and Statistical Manual for Mental Disorders, 5th edition. It was concluded that existing criteria could be augmented by including a more specific differentiation between delusions and hallucinations, address overlap with related conditions (agitation in particular), adding the possibility of symptoms emerging in the preclinical and prodromal phases, and building on developing research in disease biomarkers.ConclusionWe propose criteria, developed to improve phenotypic classification of psychosis in AD, and advance the research agenda in the field to improve epidemiological, biomarker, and genetics research in the field. These criteria serve as a complement to the International Psychogeriatric Association criteria for psychosis in neurocognitive disorders.

Published
2020

22. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need.

Author

Babulal, Ganesh M, Quiroz, Yakeel T, Albensi, Benedict C, Arenaza-Urquijo, Eider, Astell, Arlene J, Babiloni, Claudio, Bahar-Fuchs, Alex, Bell, Joanne, Bowman, Gene L, Brickman, Adam M, Chételat, Gaël, Ciro, Carrie, Cohen, Ann D, Dilworth-Anderson, Peggye, Dodge, Hiroko H, Dreux, Simone, Edland, Steven, Esbensen, Anna, Evered, Lisbeth, Ewers, Michael, Fargo, Keith N, Fortea, Juan, Gonzalez, Hector, Gustafson, Deborah R, Head, Elizabeth, Hendrix, James A, Hofer, Scott M, Johnson, Leigh A, Jutten, Roos, Kilborn, Kerry, Lanctôt, Krista L, Manly, Jennifer J, Martins, Ralph N, Mielke, Michelle M, Morris, Martha Clare, Murray, Melissa E, Oh, Esther S, Parra, Mario A, Rissman, Robert A, Roe, Catherine M, Santos, Octavio A, Scarmeas, Nikolaos, Schneider, Lon S, Schupf, Nicole, Sikkes, Sietske, Snyder, Heather M, Sohrabi, Hamid R, Stern, Yaakov, Strydom, Andre, Tang, Yi, Terrera, Graciela Muniz, Teunissen, Charlotte, Melo van Lent, Debora, Weinborn, Michael, Wesselman, Linda, Wilcock, Donna M, Zetterberg, Henrik, O'Bryant, Sid E, and International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association

Subjects
International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Humans, Alzheimer Disease, Biomedical Research, Aged, Continental Population Groups, Ethnic Groups, Healthcare Disparities, Biomarkers, Alzheimer's disease, Alzheimer's related dementias, Diversity, Ethnicity, Ethnoracial, Translational, Underserved, Geriatrics, Clinical Sciences, Neurosciences
Abstract

Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise "state-of-the-science" report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.

Published
2019

26. Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

Author

Lanctôt, Krista L, Amatniek, Joan, Ancoli‐Israel, Sonia, Arnold, Steven E, Ballard, Clive, Cohen‐Mansfield, Jiska, Ismail, Zahinoor, Lyketsos, Constantine, Miller, David S, Musiek, Erik, Osorio, Ricardo S, Rosenberg, Paul B, Satlin, Andrew, Steffens, David, Tariot, Pierre, Bain, Lisa J, Carrillo, Maria C, Hendrix, James A, Jurgens, Heidi, and Boot, Brendon

Subjects
Biological Psychology, Psychology, Dementia, Depression, Neurosciences, Clinical Trials and Supportive Activities, Acquired Cognitive Impairment, Clinical Research, Neurodegenerative, Mental Health, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Aging, Behavioral and Social Science, Alzheimer's Disease, Mental health, Neurological, Agitation, Alzheimer's disease, Apathy, Delusions, Hallucinations, Neuropsychiatric symptoms, Sleep disturbance, Trial design, Clinical sciences, Biological psychology
Abstract

Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing substantial distress for both people with dementia and their caregivers, and contributing to early institutionalization. They are among the earliest signs and symptoms of neurocognitive disorders and incipient cognitive decline, yet are under-recognized and often challenging to treat. With this in mind, the Alzheimer's Association convened a Research Roundtable in May 2016, bringing together experts from academia, industry, and regulatory agencies to discuss the latest understanding of NPSs and review the development of therapeutics and biomarkers of NPSs in AD. This review will explore the neurobiology of NPSs in AD and specific symptoms common in AD such as psychosis, agitation, apathy, depression, and sleep disturbances. In addition, clinical trial designs for NPSs in AD and regulatory considerations will be discussed.

Published
2017

29. Reduction of agitation and caregiver distress using a combination intervention of tetrahydrocannabinol and melatonin in dementia due to Alzheimer disease

Author

Arbelaez, María Juanita, primary, Gutierrez, Evelyn, additional, Sanchez, Laura Tatiana, additional, Tangarife, Maria Alejandra, additional, Delgado‐Murillo, Laura, additional, Rodriguez‐Soacha, Diego, additional, Shahnawaz, Saadia S, additional, Ghazaryan, Varduhi, additional, Naranjo, Maria Paula, additional, Venegas, Margarita, additional, Garcia, David Silva, additional, Pujals, Karen Y, additional, De Jesus, William Julio, additional, Grimaldi, Claudia, additional, Lanctôt, Krista L., additional, Hong, L Elliot, additional, and Mukunda, Ram, additional

Published
2023
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31. Investigating the effects of aerobic exercise primed anodal transcranial direct current stimulation on γ‐aminobutyric acid concentrations in mild vascular cognitive impairment

Author

Wong, Melissa, primary, Near, Jamie, additional, Tumati, Shankar, additional, Gaur, Amish, additional, Siddiqui, Mehreen, additional, Gallagher, Damien, additional, Oh, Paul I., additional, Marzolini, Susan, additional, Black, Sandra E., additional, Swardfager, Walter, additional, Graham, Simon J., additional, Ramirez, Joel, additional, Andreazza, Ana C., additional, Rapoport, Mark J., additional, Marotta, Giovanni, additional, Herrmann, Nathan, additional, Goubran, Maged, additional, Rajji, Tarek K., additional, and Lanctôt, Krista L., additional

Published
2023
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32. Beta to Theta Power Ratio in Electroencephalogram Periodic Components to Discriminate Mild Cognitive Impairment and Alzheimer’s Dementia

Author

Azami, Hamed, primary, Zrenner, Christoph, additional, Brooks, Heather, additional, Zomorrodi, Reza, additional, Blumberger, Daniel M., additional, Fischer, Corinne E., additional, Flint, Alastair, additional, Herrmann, Nathan, additional, Kumar, Sanjeev, additional, Lanctôt, Krista L., additional, Mah, Linda, additional, Mulsant, Benoit H., additional, Pollock, Bruce G., additional, and Rajji, Tarek K., additional

Published
2023
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36. Reduction of neuropsychiatric symptoms and associated caregiver distress using a tetrahydrocannabinol and melatonin combination in dementia due to Alzheimer’s disease

Author

Tangarife, Maria Alejandra, primary, Gutierrez, Evelyn, additional, Sanchez, Laura Tatiana, additional, Arbelaez, María Juanita, additional, Rodriguez‐Soacha, Diego, additional, Shahnawaz, Saadia S, additional, Ghazaryan, Varduhi, additional, Delgado‐Murillo, Laura, additional, Naranjo, Maria Paula, additional, Venegas, Margarita, additional, García, David Silva, additional, Pujals, Karen Y, additional, De Jesus, William Julio, additional, Grimaldi, Claudia, additional, Lanctôt, Krista L., additional, Hong, L Elliot, additional, and Mukunda, Ram, additional

Published
2023
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38. Investigating the impact of hypertension with and without diabetes on progression to Alzheimer’s disease: A clinic‐pathological study

Author

Ruthirakuhan, Myuri, primary, Swardfager, Walter, additional, Xiong, Lisa Y., additional, Ottoy, Julie, additional, MacIntosh, Bradley J., additional, Rabin, Jennifer S., additional, Ramirez, Joel, additional, Herrmann, Nathan, additional, Keith, Julia, additional, Lanctôt, Krista L., additional, and Black, Sandra E., additional

Published
2023
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39. Effect of tetrahydrocannabinol and melatonin combination on suicide ideation and behavior in dementia due to Alzheimer’s disease

Author

Delgado‐Murillo, Laura, primary, Gutierrez, Evelyn, additional, Sanchez, Laura Tatiana, additional, Arbelaez, María Juanita, additional, Tangarife, Maria Alejandra, additional, Rodriguez‐Soacha, Diego, additional, Shahnawaz, Saadia S, additional, Ghazaryan, Varduhi, additional, Naranjo, Maria Paula, additional, Venegas, Margarita, additional, Silva‐García, David, additional, Pujals, Karen Y, additional, De Jesus, William Julio, additional, Grimaldi, Claudia, additional, Lanctôt, Krista L., additional, Hong, L Elliot, additional, and Mukunda, Ram, additional

Published
2023
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40. Risk of motor vehicle collisions and culpability among older drivers using cannabis: a meta‐analysis

Author

Chinna‐Meyyappan, Arun, primary, Wang, Janet Hui Jue, additional, Bawa, Kritleen Kaur, additional, Ellazar, Edward A, additional, Norris‐Roozman, Emilie, additional, Naglie, Gary, additional, Herrmann, Nathan, additional, Charlton, Judith, additional, Koppel, Sjaan, additional, Castel, Saulo, additional, Lanctôt, Krista L., additional, and Rapoport, Mark J., additional

Published
2023
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42. Reduction of apathy and caregiver distress using a combination of tetrahydrocannabinol and melatonin in dementia due to Alzheimer’s disease

Author

Gutierrez, Evelyn, primary, Sanchez, Laura Tatiana, additional, Arbelaez, María Juanita, additional, Tangarife, Maria Alejandra, additional, Delgado‐Murillo, Laura, additional, Rodriguez‐Soacha, Diego, additional, Shahnawaz, Saadia S, additional, Ghazaryan, Varduhi, additional, Naranjo, Maria Paula, additional, Venegas, Margarita, additional, Silva‐García, David, additional, Pujals, Karen Y, additional, De Jesus, William Julio, additional, Grimaldi, Claudia, additional, Mukunda, Ram, additional, Hong, L Elliot, additional, and Lanctôt, Krista L., additional

Published
2023
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43. Associations between homocysteine, tau, and neurodegenerative markers in apolipoprotein ε4 non‐carriers with clinical Alzheimer’s disease

Author

Lin, William Z., primary, Yu, Di, additional, Xiong, Lisa Y., additional, Goubran, Maged, additional, Ozzoude, Miracle, additional, Kumar, Sanjeev, additional, Tang‐Wai, David F., additional, Tartaglia, Carmela, additional, Tan, Brian, additional, Bartha, Robert, additional, Haddad, Seyyed M. H., additional, Nanayakkara, Nuwan D., additional, Symons, Sean, additional, Lou, Wendy, additional, MacIntosh, Bradley J., additional, Lanctôt, Krista L., additional, Zetterberg, Henrik, additional, Black, Sandra E., additional, and Swardfager, Walter, additional

Published
2023
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44. Mapping of validated apathy scales onto the apathy diagnostic criteria for neurocognitive disorders

Author

Bawa, Kritleen Kaur, primary, Sankhe, Krushnaa, additional, Md, Daniel Bateman, additional, Cummings, Jeffrey L., additional, Ereshefsky, Larry, additional, Husain, Masud, additional, Ismail, Zahinoor, additional, Manera, Valeria, additional, Mintzer, Jacobo, additional, Moebius, Hans J., additional, Mortby, Moyra E, additional, Porsteinsson, Anton P., additional, Robert, Philippe, additional, Miller, David S., additional, and Lanctôt, Krista L., additional

Published
2023
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45. Effect of the combination of tetrahydrocannabinol and melatonin (IGC‐AD1) on blood pressure variability in patients with mild to moderate Alzheimer’s Disease

Author

Silva‐García, David, primary, Gutierrez, Evelyn, additional, Sanchez, Laura Tatiana, additional, Arbelaez, María Juanita, additional, Tangarife, Maria Alejandra, additional, Delgado‐Murillo, Laura, additional, Rodriguez‐Soacha, Diego, additional, Shahnawaz, Saadia S, additional, Ghazaryan, Varduhi, additional, Naranjo, Maria Paula, additional, Venegas, Margarita, additional, Pujals, Karen Y, additional, De Jesus, William Julio, additional, Grimaldi, Claudia, additional, Lanctôt, Krista L., additional, Hong, L Elliot, additional, and Mukunda, Ram, additional

Published
2023
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46. Blood‐based biomarkers for predicting treatment response in the Apathy in Dementia Methylphenidate Trial 2 randomized clinical trial

Author

Tumati, Shankar, primary, Vieira, Danielle, additional, Bawa, Kritleen Kaur, additional, Andreazza, Ana C., additional, Mintzer, Jacobo, additional, Scherer, Roberta, additional, Rosenberg, Paul B., additional, van Dyck, Christopher H, additional, Padala, Prasad R, additional, Brawman‐Mintzer, Olga, additional, Porsteinsson, Anton P., additional, Lerner, Alan J., additional, Craft, Suzanne, additional, Levey, Allan I., additional, Burke, William J, additional, Perin, Jamie, additional, Shade, David, additional, Herrmann, Nathan, additional, and Lanctôt, Krista L., additional

Published
2023
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47. Circulating cell‐free mitochondrial DNA (ccf‐mtDNA) and memory in mild cognitive impairment (MCI) and Alzheimer’s disease (AD)

Author

Song, Bing Xin, primary, Beroncal, Erika, additional, Andreazza, Ana C., additional, Gallagher, Damien, additional, Marzolini, Susan, additional, Rapoport, Mark J., additional, Charles, Jocelyn, additional, Herrmann, Nathan, additional, Oh, Paul I., additional, Kiss, Alex, additional, Swardfager, Walter, additional, MacIntosh, Bradley J., additional, Rajji, Tarek K., additional, Siddiqui, Mehreen, additional, Vieira, Danielle, additional, Rivet, Luc, additional, and Lanctôt, Krista L., additional

Published
2023
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48. Association between lipopolysaccharide, immune biomarkers and cerebral amyloid‐beta deposition in older adults with mild cognitive impairment & major depressive disorder

Author

Feng, Vivian, primary, Lanctôt, Krista L., additional, Herrmann, Nathan, additional, Kiss, Alex, additional, Fischer, Corinne E., additional, Flint, Alastair, additional, Mah, Linda, additional, Mulsant, Benoit H., additional, Pollock, Bruce G., additional, Rajji, Tarek K., additional, Tumati, Shankar, additional, Verhoeff, Nicolaas Paul L.G., additional, Graff‐Guerrero, Ariel, additional, and Gallagher, Damien, additional

Published
2023
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