Search

Your search keyword '"Landau, Klara"' showing total 426 results
Start Over Author "Landau, Klara"
426 results on '"Landau, Klara"'

2. Iron Deficiency and Incident Infections among Community-Dwelling Adults Age 70 Years and Older: Results from the DO-HEALTH Study

Author

Lanz, P., Wieczorek, M., Sadlon, A., de Godoi Rezende Costa Molino, C., Abderhalden, L. A., Schaer, D. J., Spahn, D. R., Freystätter, G., Orav, E. J., Egli, A., Bischoff-Ferrari, Heike A., Rival, Sandrine, Guyonnet, Sophie, Biver, Emmanuel, Merminod, Fanny, Bridenbaugh, Stephanie, Suhm, Norbert, Duarte, Cátia C. M., Pinto, Ana Filipa, Felsenberg, Dieter, Börst, Hendrikje, Spicher, Anna, Felson, David T., Mccloskey, Eugene V., Johansson, Elena, Watzl, Bernhard, Gomez, Manuel Rodriguez, Tsourdi, Elena, Rauner, Martina, Halbout, Philippe, Ferrari, Stephen M., Gut, Benno, Ba, Marième, Schegg, Jonas Wittwer, Etheve, Stéphane, Eggersdorfer, Manfred, Delannoy, Carla Sofia, Reuschling, Monika, Staehelin, Hannes B., Walter, Paul W., Dick, Walter, Fried, Michael, von Eckardstein, Arnold, Simmen, Hans-Peter, Langhans, Wolfgang, Zinkernagel, Annelies, Mueller, Nicolas, Distler, Oliver, Graetz, Klaus, Nitschke, Ina, Dietrich, Thomas, Baer, Walter, Landau, Klara, Ruschitzka, Frank, Manz, Markus, and Burckhardt, Peter

Published
2022
Full Text
View/download PDF

10. Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy

Author

Catarino, Claudia B., von Livonius, Bettina, Priglinger, Claudia, Banik, Rudrani, Matloob, Selma, Tamhankar, Madhura A., Castillo, Lorena, Friedburg, Christoph, Halfpenny, Christopher A., Lincoln, John A., Traber, Ghislaine L., Acaroglu, Gölge, Black, Graeme C. M., Doncel, Carlos, Fraser, Clare L., Jakubaszko, Joanna, Landau, Klara, Langenegger, Stefan J., Muñoz-Negrete, Francisco J., Newman, Nancy J., Poulton, Joanna, Scoppettuolo, Elisabetta, Subramanian, Prem, Toosy, Ahmed T., Vidal, Mariona, Vincent, Andrea L., Votruba, Marcela, Zarowski, Marcin, Zermansky, Adam, Lob, Felice, Rudolph, Günther, Mikazans, Oskars, Silva, Magda, Llòria, Xavier, Metz, Günther, and Klopstock, Thomas

Published
2020
Full Text
View/download PDF

16. Lateral Geniculate Nucleus Volume Determined on MRI Correlates With Corresponding Ganglion Cell Layer Loss in Acquired Human Postgeniculate Lesions

Author

Simmen, Cyril Fabian, Fierz, Fabienne Catherine, Michels, Lars, Aldusary, Njoud, Landau, Klara, Piccirelli, Marco, Traber, Ghislaine Lieselotte, and University of Zurich

Subjects
10018 Ophthalmology Clinic, 2804 Cellular and Molecular Neuroscience, Geniculate Bodies, 610 Medicine & health, General Medicine, 2731 Ophthalmology, Magnetic Resonance Imaging, Retina, 2809 Sensory Systems, 10043 Clinic for Neuroradiology, Case-Control Studies, Humans, Visual Pathways, Tomography, Optical Coherence
Abstract

Purpose: To quantitatively assess lateral geniculate nucleus (LGN) volume loss in the presence of lesions in the postgeniculate pathway and its correlation with optical coherence tomography retinal parameters. Methods: This was a case control study of patients recruited at the University Hospital Zurich, Switzerland. Nine patients who were suffering from lesions in the postgeniculate pathway acquired at least 3 months earlier participated. Retinal parameters were analyzed using spectral domain optical coherence tomography and a newly developed magnetic resonance imaging protocol with improved contrast to noise ratio was applied to measure LGN volume. Results: The affected LGN volume in the patients (mean volume 73.89 ± 39.08 mm3) was significantly smaller compared with the contralateral unaffected LGN (mean volume 131.43 ± 12.75 mm3), as well as compared with healthy controls (mean volume 107 ± 24.4 mm3). Additionally, the ganglion cell layer thickness corresponding with the affected versus unaffected side within the patient group differed significantly (mean thickness 40.5 ± 4.11 µm vs 45.7 ± 4.79 µm) compared with other retinal parameters. A significant linear correlation could also be shown between relative LGN volume loss and ganglion cell layer thickness decrease. Conclusions: Corresponding LGN volume reduction could be shown in patients with postgeniculate lesions using a newly developed magnetic resonance imaging protocol. LGN volume decrease correlated with ganglion cell layer thickness reduction as a sign of trans-synaptic retrograde neuronal degeneration., Investigative Ophthalmology & Visual Science, 63 (9), ISSN:0146-0404

Published
2022

24. Prächiasmaler Sehverlust

Author

Landau, Klara, Thiel, Michael A., editor, Bernauer, Wolfgang, editor, Zürcher Schüpfer, Marlis, editor, and Schmid, Martin K., editor

Published
2013
Full Text
View/download PDF

27. Optikusneuritis

Author

Landau, Klara, Weber, Peter, University of Zurich, and Pleyer, Uwe

Subjects
10018 Ophthalmology Clinic, 610 Medicine & health
Published
2021

28. Optikusneuritis

Author

Pleyer, Uwe, Pleyer, U ( Uwe ), Landau, Klara, Weber, Peter, Pleyer, Uwe, Pleyer, U ( Uwe ), Landau, Klara, and Weber, Peter

Abstract

Optikusneuritis, im Englischen optic neuritis, bezeichnet eine Entzündung des Nervus opticus und stellt somit eine Affektion des Zentralen Nervensystems (ZNS) dar. Weil die Symptomatik das visuelle System betrifft, wenden sich Betroffene primär an eine augenärztliche Einrichtung. Im Verlauf der Erkrankung ist eine enge interdisziplinäre Zusammenarbeit, vorwiegend mit der Neurologie, sehr wichtig. Es ist jedoch entscheidend, dass die augenärztliche Expertise nicht nur bei der Diagnostik, sondern auch bei der Verlaufsbeobachtung, der Therapie und der Patientenberatung einfließt.

Published
2021

29. Case Report: Oculomotor Palsy With Cyclic Spasms in a Patient With Charcot-Marie-Tooth Disease Type 1

Author

Weber, Konrad P, Bockisch, Christopher J, Landau, Klara, Weber, Konrad P, Bockisch, Christopher J, and Landau, Klara

Abstract

Oculomotor palsy with cyclic spasms is an extremely rare condition whose exact pathophysiology remains a mystery. We followed a boy from the onset of symptoms at the age of ten months until 15 years and documented the case with video oculography. In addition, he was diagnosed with hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease type 1). Although a pure coincidence cannot be ruled out, it is conceivable that the underlying demyelinating neuropathy of this patient rendered the oculomotor nerve more susceptible to damage.

Published
2021

33. Practice Preferences: Temporal Artery Biopsy versus Doppler Ultrasound in the Work-Up of Giant Cell Arteritis

Author

Ing, Edsel, Qinyuan (Alis) Xu, Chuo, Jean, Femida Kherani, Landau, Klara, University of Zurich, and Ing, Edsel

Subjects
10018 Ophthalmology Clinic, Ophthalmology, 2728 Neurology (clinical), Clinical Neurology, 610 Medicine & health, 2731 Ophthalmology
Abstract

To determine whether temporal artery biopsy (TABx) or Doppler ultrasound (US) of the temporal artery is the preferred confirmatory test for giant cell arteritis, an online survey of ophthalmologists and neurologists in North America, Europe and Israel was conducted in 2019; Canadian rheumatologists were also included. There were 406 survey participants with an estimated survey response rate of 18%. Ninety-four per cent of North American practitioners preferred TABx compared with 74% of their European counterparts. Two per cent of North American practitioners preferred Doppler US versus 24% of European physicians. Regional differences were statistically significant (p < .001).

Published
2020
Full Text
View/download PDF

34. Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy

Author

Catarino, Claudia B, von Livonius, Bettina, Priglinger, Claudia, Banik, Rudrani, Matloob, Selma, Tamhankar, Madhura A, Castillo, Lorena, Friedburg, Christoph, Halfpenny, Christopher A, Lincoln, John A, Traber, Ghislaine L, Acaroglu, Gölge, Black, Graeme C M, Doncel, Carlos, Fraser, Clare L, Jakubaszko, Joanna, Landau, Klara, Langenegger, Stefan J, Muñoz-Negrete, Francisco J, Newman, Nancy J, Poulton, Joanna, Scoppettuolo, Elisabetta, Subramanian, Prem, Toosy, Ahmed T, Vidal, Mariona, Vincent, Andrea L, Votruba, Marcela, Zarowski, Marcin, Zermansky, Adam, Lob, Felice, Rudolph, Günther, Mikazans, Oskars, Silva, Magda, Lloria, Xavier, Metz, Günther, Klopstock, Thomas, Catarino, Claudia B, von Livonius, Bettina, Priglinger, Claudia, Banik, Rudrani, Matloob, Selma, Tamhankar, Madhura A, Castillo, Lorena, Friedburg, Christoph, Halfpenny, Christopher A, Lincoln, John A, Traber, Ghislaine L, Acaroglu, Gölge, Black, Graeme C M, Doncel, Carlos, Fraser, Clare L, Jakubaszko, Joanna, Landau, Klara, Langenegger, Stefan J, Muñoz-Negrete, Francisco J, Newman, Nancy J, Poulton, Joanna, Scoppettuolo, Elisabetta, Subramanian, Prem, Toosy, Ahmed T, Vidal, Mariona, Vincent, Andrea L, Votruba, Marcela, Zarowski, Marcin, Zermansky, Adam, Lob, Felice, Rudolph, Günther, Mikazans, Oskars, Silva, Magda, Lloria, Xavier, Metz, Günther, and Klopstock, Thomas

Abstract

BACKGROUND: Leber hereditary optic neuropathy (LHON) leads to bilateral central vision loss. In a clinical trial setting, idebenone has been shown to be safe and to provide a trend toward improved visual acuity, but long-term evidence of effectiveness in real-world clinical practice is sparse. METHODS: Open-label, multicenter, retrospective, noncontrolled analysis of long-term visual acuity and safety in 111 LHON patients treated with idebenone (900 mg/day) in an expanded access program. Eligible patients had a confirmed mitochondrial DNA mutation and had experienced the onset of symptoms (most recent eye) within 1 year before enrollment. Data on visual acuity and adverse events were collected as per normal clinical practice. Efficacy was assessed as the proportion of patients with either a clinically relevant recovery (CRR) or a clinically relevant stabilization (CRS) of visual acuity. In the case of CRR, time to and magnitude of recovery over the course of time were also assessed. RESULTS: At time of analysis, 87 patients had provided longitudinal efficacy data. Average treatment duration was 25.6 months. CRR was observed in 46.0% of patients. Analysis of treatment effect by duration showed that the proportion of patients with recovery and the magnitude of recovery increased with treatment duration. Average gain in best-corrected visual acuity for responders was 0.72 logarithm of the minimal angle of resolution (logMAR), equivalent to more than 7 lines on the Early Treatment Diabetic Retinopathy Study (ETDRS) chart. Furthermore, 50% of patients who had a visual acuity below 1.0 logMAR in at least one eye at initiation of treatment successfully maintained their vision below this threshold by last observation. Idebenone was well tolerated, with most adverse events classified as minor. CONCLUSIONS: These data demonstrate the benefit of idebenone treatment in recovering lost vision and maintaining good residual vision in a real-world setting. Together, these findings

Published
2020

35. Abnormal Connectivity and Brain Structure in Patients With Visual Snow

Author

Aldusary, Njoud, Traber, Ghislaine L, Freund, Patrick, Fierz, Fabienne C, Weber, Konrad P; https://orcid.org/0000-0003-2526-4582, Baeshen, Arwa, Alghamdi, Jamaan, Saliju, Bujar, Pazahr, Shila, Mazloum, Reza, Alshehri, Fahad, Landau, Klara, Kollias, Spyros, Piccirelli, Marco, Michels, Lars, Aldusary, Njoud, Traber, Ghislaine L, Freund, Patrick, Fierz, Fabienne C, Weber, Konrad P; https://orcid.org/0000-0003-2526-4582, Baeshen, Arwa, Alghamdi, Jamaan, Saliju, Bujar, Pazahr, Shila, Mazloum, Reza, Alshehri, Fahad, Landau, Klara, Kollias, Spyros, Piccirelli, Marco, and Michels, Lars

Abstract

Objective: Visual snow (VS) is a distressing, life-impacting condition with persistent visual phenomena. VS patients show cerebral hypermetabolism within the visual cortex, resulting in altered neuronal excitability. We hypothesized to see disease-dependent alterations in functional connectivity and gray matter volume (GMV) in regions associated with visual perception. Methods: Nineteen patients with VS and 16 sex- and age-matched controls were recruited. Functional magnetic resonance imaging (fMRI) was applied to examine resting-state functional connectivity (rsFC). Volume changes were assessed by means of voxel-based morphometry (VBM). Finally, we assessed associations between MRI indices and clinical parameters. Results: Patients with VS showed hyperconnectivity between extrastriate visual and inferior temporal brain regions and also between prefrontal and parietal (angular cortex) brain regions (p < 0.05, corrected for age and migraine occurrence). In addition, patients showed increased GMV in the right lingual gyrus (p < 0.05 corrected). Symptom duration positively correlated with GMV in both lingual gyri (p < 0.01 corrected). Conclusion: This study found VS to be associated with both functional and structural changes in the early and higher visual cortex, as well as the temporal cortex. These brain regions are involved in visual processing, memory, spatial attention, and cognitive control. We conclude that VS is not just confined to the visual system and that both functional and structural changes arise in VS patients, be it as an epiphenomenon or a direct contributor to the pathomechanism of VS. These in vivo neuroimaging biomarkers may hold potential as objective outcome measures of this so far purely subjective condition

Published
2020

42. Abnormal Connectivity and Brain Structure in Patients With Visual Snow

Author

Aldusary, Njoud, primary, Traber, Ghislaine L., additional, Freund, Patrick, additional, Fierz, Fabienne C., additional, Weber, Konrad P., additional, Baeshen, Arwa, additional, Alghamdi, Jamaan, additional, Saliju, Bujar, additional, Pazahr, Shila, additional, Mazloum, Reza, additional, Alshehri, Fahad, additional, Landau, Klara, additional, Kollias, Spyros, additional, Piccirelli, Marco, additional, and Michels, Lars, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results