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1. New Device to Measure Cross-Sectional Areas and Segmental Volumes of Objects and Limbs

Author

Houwen F, Stemkens J, van Sonsbeek D, van Sonsbeek R, van der Hulst R, and van Langen H

Subjects
volumetric, continuous profile, local volume, usable accuracy, objective., Medical technology, R855-855.5
Abstract

Frans Houwen,1 Johannes Stemkens,2 Don van Sonsbeek,3 Robby van Sonsbeek,3 René van der Hulst,4 Herman van Langen5 1Peracutus B.V., Kronenberg, the Netherlands; 2Stemkens.Com B.V., Roggel, the Netherlands; 3D-Sight B.V., Maastricht, the Netherlands; 4Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands; 5Department of Medical Physics and Devices, VieCuri Medical Centre, Venlo, the NetherlandsCorrespondence: Frans Houwen, Peracutus B.V., Peelstraat 4a, Kronenberg, 5976 NL, the Netherlands, Tel +31-650234240, Email frans.houwen@peracutus.comPurpose: High accuracy volume measurements have important implications in different medical and non-medical situations. All methods used to date have challenges to achieve a usable clinical accuracy. Moreover, current methods have limitations to measure segmental volumes. We developed a new device that is able to measure a continuous profile of the cross-sectional areas along an object. Herewith the total volume of an object or any part of it are correspondingly determined.Methods: The Peracutus Aqua Meth (PAM) generates continuous profiles of cross-sectional areas. Water is pumped in or out of a measuring unit at a nearly fixed flow rate and the speed of the water level (dh/dt) is measured continuously using a pressure sensor at the bottom. The change of the water level is a measure for the cross-sectional area of an object at any height. Signal processing is required to obtain valuable measurements. Three static objects and an arm of a test object were measured to demonstrate the accuracy and repeatability of the new device.Results: Cross-sectional areas of a PVC pipe obtained with the PAM and with a caliper were compared. The differences between the two methods were less than 1.3%. Volume measurements of two mannequin arms show standard deviations of 0.37% and 0.34%, respectively, whereas the standard deviation of the volume measurement of a genuine arm was only 1.07%. These figures surpass reported clinical accuracy.Conclusion: The new device demonstrates that determining the cross-section and its volumes of objects is possible in an accurate, reliable, and objective way. The results show that segmental volume measurements of human limbs are possible. Application in clinical and non-clinical situations seems meaningful.Keywords: volumetric, continuous profile, local volume, usable accuracy, objective

Published
2023

5. The long-term prognostic value of serum 25(OH)D, albumin, and LL-37 levels in acute respiratory diseases among older adults

Author

Aronen, M. (Matti), Viikari, L. (Laura), Langen, H. (Henriikka), Kohonen, I. (Ia), Wuorela, M. (Maarit), Vuorinen, T. (Tytti), Söderlund-Venermo, M. (Maria), Viitanen, M. (Matti), Camargo Jr, C. A. (Carlos Arturo), Vahlberg, T. (Tero), Jartti, T. (Tuomas), Aronen, M. (Matti), Viikari, L. (Laura), Langen, H. (Henriikka), Kohonen, I. (Ia), Wuorela, M. (Maarit), Vuorinen, T. (Tytti), Söderlund-Venermo, M. (Maria), Viitanen, M. (Matti), Camargo Jr, C. A. (Carlos Arturo), Vahlberg, T. (Tero), and Jartti, T. (Tuomas)

Abstract

Background: Older adults are more susceptible to respiratory tract infection than healthy working age adults. The increased susceptibility of older adults is thought to be interlinked with vitamin D status, nourishment, and immunological state in general. Data are scarce whether these parameters could serve as prognostic markers. Aim: To study whether serum 25(OH)D, albumin, and LL-37 level could give prognostic value of long-term survival in the older adults with multimorbidity and acute respiratory infection. Methods: Consecutive episodes of hospital care of patients 65 years and older with respiratory symptoms were prospectively studied as a cohort. Standard clinical questionnaire was filled by the study physician. Laboratory markers included serum levels of 25(OH)D, albumin and LL-37, C-reactive protein (CRP), white blood cell count (WBC) and polymerase chain reaction diagnostics for 14 respiratory viruses. Pneumonia was confirmed by chest radiographs. Respiratory illness severity, death at ward, length of hospital stays, and 5-year survival were used as outcomes. Results: In total, 289 older adult patients with mean age of 83 years were included in the study. Serum 25(OH)D deficiency (< 50 nmol/liter) was present in 59% and hypoalbuminemia (< 3.5 g/dL) in 55% of the study patients. Low serum albumin level was associated to one, two- and five-year mortality after hospital stay (all P <.05). In addition, it was associated with pneumonia, dyspnea, over 13-night long stay at ward and death at ward (all P < .05). No associations were seen between serum 25(OH)D and LL-37 levels and disease severity, short-term clinical outcome, or long-term survival. Associations between serum 25(OH)D, albumin, and LL-37 levels and respiratory virus presence were not seen. Conclusions: Serum albumin level on admission seems to give valuable information about the patients’ general health and recovery potential in treating older adults with respiratory symptoms. Se

Published
2022

11. A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium

Author

Emri, E, Kortvely, E, Dammeier, S, Klose, F, Simpson, D, Hollander, AI, Ueffing, M, Lengyel, I, Acar, E, Ajana, S, Arango?gonzalez, B, Armento, A, Badura, F, Bartz?schmidt, U, Biarnes, M, Borrell, A, de Breuk, A, De la Cerda, B, Colijn, Annemarie, Cougnard?gregoire, A, Delcourt, C, Diether, S, Endermann, T, Ferraro, LL, Garcia, M, Heesterbeek, TJ, Honisch, S, Kilger, E, Klaver, Caroline, Langen, H, Meester - Smoor, Magda, Merle, BMJ, Mones, J, Nogoceke, E, Peto, T, Pool, FM, Rodriguez, E, Sousa, J, Thee, Eric, Verzijden, T (Timo), Zumbansen, M, and Ophthalmology

Subjects
0301 basic medicine, proteome, retinal pigment epithelium, lcsh:TX341-641, Biology, medicine.disease_cause, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], Article, Transforming Growth Factor beta1, Transcriptome, Macular Degeneration, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, TGFB1, Cell Adhesion, Electric Impedance, medicine, Humans, Micronutrients, Cell adhesion, age-related macular degeneration, Cells, Cultured, Nutrition and Dietetics, Retinal pigment epithelium, Microvilli, Pigmentation, zinc, Cell Polarity, gene set enrichment, Extracellular Matrix, Cell biology, Oxidative Stress, Protein Transport, secretome, 030104 developmental biology, medicine.anatomical_structure, Secretory protein, Cell culture, Proteome, 030221 ophthalmology & optometry, sense organs, transcriptome, lcsh:Nutrition. Foods and food supply, Oxidative stress, Signal Transduction, Food Science, Extracellular matrix organization
Abstract

In age-related macular degeneration (AMD), both systemic and local zinc levels decline. Elevation of zinc in clinical studies delayed the progression to end-stage AMD. However, the molecular pathways underpinning this beneficial effect are not yet identified. In this study, we used differentiated primary human fetal retinal pigment epithelium (RPE) cultures and long-term zinc supplementation to carry out a combined transcriptome, proteome and secretome analysis from three genetically different human donors. After combining significant differences, we identified the complex molecular networks using Database for Annotation, Visualization and Integrated Discovery (DAVID) and Ingenuity Pathway Analysis (IPA). The cell cultures from the three donors showed extensive pigmentation, development of microvilli and basal infoldings and responded to zinc supplementation with an increase in transepithelial electrical resistance (TEER) (apical supplementation: 443.2 &plusmn, 79.3%, basal supplementation: 424.9 &plusmn, 116.8%, compared to control: 317.5 &plusmn, 98.2%). Significant changes were observed in the expression of 1044 genes, 151 cellular proteins and 124 secreted proteins. Gene set enrichment analysis revealed changes in specific molecular pathways related to cell adhesion/polarity, extracellular matrix organization, protein processing/transport, and oxidative stress response by zinc and identified a key upstream regulator effect similar to that of TGFB1.

Published
2020
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19. A Haptic Tele-operated System for Microassembly

Author

Estevez, P., primary, Khan, S., additional, Lambert, P., additional, Porta, M., additional, Polat, I., additional, Scherer, C., additional, Tichem, M., additional, Staufer, U., additional, Langen, H. H., additional, and Schmidt, R. Munnig, additional

Published
2010
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25. Integrating Metabolomics, Genomics, and Disease Pathways in Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Acar, ?E, Lores-Motta, L, Colijn, Annemarie, Smoor, Magda, Verzijden, T (Timo), Cougnard-Gregoire, A, Ajana, S, Merle, BMJ, de Breuk, A, Heesterbeek, TJ, Akker, Erik, Daha, MR, Claes, B, Pauleikhoff, D, Hense, H W, Duijn, Cornelia, Fauser, S, Hoyng, CB, Delcourt, C, Klaver, Caroline, Galesloot, TE, Hollander, AI, Arango-Gonzalez, B, Armento, A, Badura, F, Bhatia, V, Bhattacharya, SS, Biarnés, M, Borrell, A, Calado, SM, Dammeier, S, Cerda, BDL, Diaz-Corrales, FJ, Diether, S, Emri, E, Endermann, T, Ferraro, LL, Garcia, M, Honisch, S, Kilger, E, Kortvely, E, Lastrucci, C, Langen, H, Lengyel, I, Luthert, P, Monés, J, Nogoceke, E, Peto, T, Pool, FM, Rodriguez-Bocanegra, E, Serrano, L, Sousa, J, Thee, E, Ueffing, M, Ulrich Bartz-Schmidt, KU, Zumbansen, M, Epidemiology, and Ophthalmology

Published
2020

27. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Merle, B.M.J., Colijn, J.M., Cougnard-Gregoire, A., Koning-Backus, A.P.M. de, Delyfer, M.N., Kiefte-de Jong, J.C., Meester-Smoor, M., Feart, C., Verzijden, T., Samieri, C., Franco, O.H., Korobelnik, J.F., Klaver, C.C.W., Delcourt, C., Ajana, S., Arango-Gonzalez, B., Armento, A., Arndt, V., Bhatia, V., Bhattacharya, S.S., Biarnes, M., Borrell, A., Buhren, S., Calado, S.M., Dammeier, S., Jong, E.K. de, Cerda, B. de la, Hollander, A.I. den, Diaz-Corrales, F.J., Diether, S., Emri, E., Endermann, T., Ferraro, L.L., Garcia, M., Heesterbeek, T.J., Honisch, S., Hoyng, C.B., Kersten, E., Kilger, E., Langen, H., Lengyel, I., Luthert, P., Maugeais, C., Mones, J., Nogoceke, E., Peto, T., Pool, F.M., Rodriguez, E., Ueffing, M., Bartz-Schmidt, K.U.U., Leeuwen, E.M. van, Zumbansen, M., Vasiliev, V., and EYE-RISK Consortium

Published
2019

28. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration Evidence from the EYE-RISK and European Eye Epidemiology Consortia

Author

Colijn, J.M., Hollander, A.I. den, Demirkan, A., Cougnard-Gregoire, A., Verzijden, T., Kersten, E., Meester-Smoor, M.A., Merle, B.M.J., Papageorgiou, G., Ahmad, S., Mulder, M.T., Costa, M.A., Benlian, P., Bertelsen, G., Bron, A.M., Claes, B., Creuzot-Garcher, C., Erke, M.G., Fauser, S., Foster, P.J., Hammond, C.J., Hense, H.W., Hoyng, C.B., Khawaja, A.P., Korobelnik, J.F., Piermarocchi, S., Segato, T., Silva, R., Souied, E.H., Williams, K.M., Duijn, C.M. van, Delcourt, C., Klaver, C.C.W., Acar, N., Altay, L., Anastosopoulos, E., Azuara-Blanco, A., Berendschot, T., Bergen, A., Binquet, C., Bird, A., Bobak, M., Larsen, M.B., Boon, C., Bourne, R., Bretillon, L., Broe, R., Bron, A., Buitendijk, G., Cachulo, M.L., Capuano, V., Carriere, I., Chakravarthy, U., Chan, M., Chang, P., Colijn, J., Cree, A., Cumberland, P., Cunha-Vaz, J., Daien, V., Jong, E. de, Deak, G., Delyfer, M.N., Hollander, A. den, Dietzel, M., Faria, P., Farinha, C., Finger, R., Fletcher, A., Foster, P., Founti, P., Gorgels, T., Grauslund, J., Grus, F., Hammond, C., Heesterbeek, T., Hermann, M., Hoehn, R., Hogg, R., Holz, F., Hoyng, C., Jansonius, N., Janssen, S., Khawaja, A., Klaver, C., Lamparter, J., Goff, M. le, Lehtimaki, T., Leung, I., Lotery, A., Mauschitz, M., Meester, M., Merle, B., Westrup, V.M.Z., Midena, E., Miotto, S., Mirshahi, A., Mohan-Said, S., Mueller, M., Muldrew, A., Murta, J., Nickels, S., Nunes, S., Owen, C., Peto, T., Pfeiffer, N., Prokofyeva, E., Rahi, J., Raitakari, O., Rauscher, F., Ribeiro, L., Rougier, M.B., Rudnicka, A., Sahel, J., Salonikiou, A., Sanchez, C., Schick, T., Schmitz-Valckenberg, S., Schuster, A., Schweitzer, C., Shehata, J., Silvestri, G., Simader, C., Souied, E., Speckauskas, M., Springelkamp, H., Tapp, R., Topouzis, F., Leeuwen, E. van, Verhoeven, V., Vingerling, H., Hanno, T. von, Williams, K., Wolfram, C., Yip, J., Zerbib, J., Ajana, S., Arango-Gonzalez, B., Arndt, V., Bhatia, V., Bhattacharya, S.S., Biarnes, M., Borrell, A., Buhren, S., Calado, S.M., Dammeier, S., Jong, E.K. de, Cerda, B. de la, Diaz-Corrales, F.J., Diether, S., Emri, E., Endermann, T., Ferraro, L.L., Garcia, M., Heesterbeek, T.J., Honisch, S., Kilger, E., Langen, H., Lengyel, I., Luthert, P., Maugeais, C., Meester-Smoor, M., Inserm, B.M.J.M., Mones, J., Nogoceke, E., Pool, F.M., Rodriguez, E., Ueffing, M., Bartz-Schmidt, K.U.U., Leeuwen, E.M. van, Zumbansen, M., European Eye Epidemiology Consorti, and EYE-RISK Consortium

Published
2019

29. A multi‐omics approach identifies key regulatory pathways induced by long‐term zinc supplementation in human primary retinal pigment epithelium

Author

Emri, E. (Eszter), Kortvely, E., Dammeier, S., Klose, F., Simpson, D., Hollander, A.I., Ueffing, M., Lengyel, I., Acar, E., Ajana, S., Arango‐gonzalez, B., Armento, A., Badura, F., Bartz‐schmidt, U., Biarnes, M., Borrell, A., de Breuk, A., De la Cerda, B., Colijn, J.M. (Johanna), Cougnard‐gregoire, A., Delcourt, C, Diether, S., Endermann, T., Ferraro, L.L., Garcia, M. (Melissa), Heesterbeek, T.J., Honisch, S., Kilger, E., Klaver, C.C.W. (Caroline), Langen, H., Meester‐smoor, M., Merle, B.M.J., Mones, J., Nogoceke, E., Peto, T. (Tünde), Pool, F.M., Rodríguez, P.M., Sousa, J., Thee, E., Verzijden, T., Zumbansen, M., Emri, E. (Eszter), Kortvely, E., Dammeier, S., Klose, F., Simpson, D., Hollander, A.I., Ueffing, M., Lengyel, I., Acar, E., Ajana, S., Arango‐gonzalez, B., Armento, A., Badura, F., Bartz‐schmidt, U., Biarnes, M., Borrell, A., de Breuk, A., De la Cerda, B., Colijn, J.M. (Johanna), Cougnard‐gregoire, A., Delcourt, C, Diether, S., Endermann, T., Ferraro, L.L., Garcia, M. (Melissa), Heesterbeek, T.J., Honisch, S., Kilger, E., Klaver, C.C.W. (Caroline), Langen, H., Meester‐smoor, M., Merle, B.M.J., Mones, J., Nogoceke, E., Peto, T. (Tünde), Pool, F.M., Rodríguez, P.M., Sousa, J., Thee, E., Verzijden, T., and Zumbansen, M.

Abstract

In age-related macular degeneration (AMD), both systemic and local zinc levels decline. Elevation of zinc in clinical studies delayed the progression to end-stage AMD. However, the molecular pathways underpinning this beneficial effect are not yet identified. In this study, we used differentiated primary human fetal retinal pigment epithelium (RPE) cultures and long-term zinc supplementation to carry out a combined transcriptome, proteome and secretome analysis from three genetically different human donors. After combining significant differences, we identified the complex molecular networks using Database for Annotation, Visualization and Integrated Discovery (DAVID) and Ingenuity Pathway Analysis (IPA). The cell cultures from the three donors showed extensive pigmentation, development of microvilli and basal infoldings and responded to zinc supplementation with an increase in transepithelial electrical resistance (TEER) (apical supplementation: 443.2 ± 79.3%, basal supplementation: 424.9 ± 116.8%, compared to control: 317.5 ± 98.2%). Significant changes were observed in the expression of 1044 genes, 151 cellular proteins and 124 secreted proteins. Gene set enrichment analysis revealed changes in specific molecular pathways related to cell adhesion/polarity, extracellular matrix organization, protein processing/transport, and oxidative stress response by zinc and identified a key upstream regulator effect similar to that of TGFB1.

Published
2020
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30. A multi?omics approach identifies key regulatory pathways induced by long?term zinc supplementation in human primary retinal pigment epithelium

Author

Emri, E, Kortvely, E, Dammeier, S, Klose, F, Simpson, D, Hollander, AI, Ueffing, M, Lengyel, I, Acar, E, Ajana, S, Arango?gonzalez, B, Armento, A, Badura, F, Bartz?schmidt, U, Biarnes, M, Borrell, A, de Breuk, A, De la Cerda, B, Colijn, Annemarie, Cougnard?gregoire, A, Delcourt, C, Diether, S, Endermann, T, Ferraro, LL, Garcia, M, Heesterbeek, TJ, Honisch, S, Kilger, E, Klaver, Caroline, Langen, H, Meester - Smoor, Magda, Merle, BMJ, Mones, J, Nogoceke, E, Peto, T, Pool, FM, Rodriguez, E, Sousa, J, Thee, Eric, Verzijden, T (Timo), Zumbansen, M, Emri, E, Kortvely, E, Dammeier, S, Klose, F, Simpson, D, Hollander, AI, Ueffing, M, Lengyel, I, Acar, E, Ajana, S, Arango?gonzalez, B, Armento, A, Badura, F, Bartz?schmidt, U, Biarnes, M, Borrell, A, de Breuk, A, De la Cerda, B, Colijn, Annemarie, Cougnard?gregoire, A, Delcourt, C, Diether, S, Endermann, T, Ferraro, LL, Garcia, M, Heesterbeek, TJ, Honisch, S, Kilger, E, Klaver, Caroline, Langen, H, Meester - Smoor, Magda, Merle, BMJ, Mones, J, Nogoceke, E, Peto, T, Pool, FM, Rodriguez, E, Sousa, J, Thee, Eric, Verzijden, T (Timo), and Zumbansen, M

Published
2020

35. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia

Author

Colijn, J. M., Verzijden, T., Meester-Smoor, M. A., Klaver, C. C. W., Demirkan, A., Ahmad, S., van Duijn, C. M., den Hollander, A. I., Kersten, E., Hoyng, C. B., Cougnard-Gregoire, A., Merle, B. M. J., Korobelnik, J. -F., Delcourt, C., Papageorgiou, G., Mulder, M. T., Costa, M. A., Silva, R., Benlian, P., Bertelsen, G., Bron, A. M., Creuzot-Garcher, C., Claes, B., Hense, H. -W., Erke, M. G., Fauser, S., Foster, P. J., Khawaja, A. P., Hammond, C. J., Williams, K. M., Piermarocchi, S., Segato, T., Souied, E. H., Acar, N., Altay, L., Anastosopoulos, E., Azuara-Blanco, A., Berendschot, T., Bergen, A., Binquet, C., Bird, A., Bobak, M., Larsen, M. B., Boon, C., Bourne, R., Bretillon, L., Broe, R., Bron, A., Buitendijk, G., Cachulo, M. L., Capuano, V., Carriere, I., Chakravarthy, U., Chan, M., Chang, P., Colijn, J., Cree, A., Cumberland, P., Cunha-Vaz, J., Daien, V., De Jong, E., Deak, G., Delyfer, M. -N., Hollander, A. D., Dietzel, M., Faria, P., Farinha, C., Finger, R., Fletcher, A., Foster, P., Founti, P., Gorgels, T., Grauslund, J., Grus, F., Hammond, C., Heesterbeek, T., Hermann, M., Hoehn, R., Hogg, R., Holz, F., Hoyng, C., Jansonius, N., Janssen, S., de Jong, E., Khawaja, A., Klaver, C., Lamparter, J., Le Goff, M., Lehtimaki, T., Leung, I., Lotery, A., Mauschitz, M., Meester, M., Merle, B., Meyer zu Westrup, V., Midena, E., Miotto, S., Mirshahi, A., Mohan-Said, S., Mueller, M., Muldrew, A., Murta, J., Nickels, S., Nunes, S., Owen, C., Peto, T., Pfeiffer, N., Prokofyeva, E., Rahi, J., Raitakari, O., Rauscher, F., Ribeiro, L., Rougier, M. -B., Rudnicka, A., Randjvar, Sahel, Salonikiou, A., Sanchez, C., Schick, T., Schmitz-Valckenberg, S., Schuster, A., Schweitzer, C., Shehata, J., Silvestri, G., Simader, C., Souied, E., Speckauskas, M., Springelkamp, H., Tapp, R., Topouzis, F., van Leeuwen, E., Verhoeven, V., Vingerling, H., Von Hanno, T., Williams, K., Wolfram, C., Yip, J., Zerbib, J., Ajana, S., Arango-Gonzalez, B., Arndt, V., Bhatia, V., Bhattacharya, S. S., Biarnes, M., Borrell, A., Buhren, S., Calado, S. M., Dammeier, S., de Jong, E. K., De la Cerda, B., Diaz-Corrales, F. J., Diether, S., Emri, E., Endermann, T., Ferraro, L. L., Garcia, M., Heesterbeek, T. J., Honisch, S., Kilger, E., Langen, H., Lengyel, I., Luthert, P., Maugeais, C., Meester-Smoor, M., Merle Inserm, B. M. J., Mones, J., Nogoceke, E., Pool, F. M., Rodriguez, E., Ueffing, M., Ulrich Bartz-Schmidt, K. U., van Leeuwen, E. M., and Zumbansen, M.

Subjects
Male, Magnetic Resonance Spectroscopy, HDL, genetic structures, European Continental Ancestry Group, Polymorphism, Single Nucleotide, White People, LDL, Macular Degeneration, Risk Factors, 80 and over, Odds Ratio, Humans, Metabolomics, European Union, Polymorphism, Triglycerides, Aged, Aged, 80 and over, Cholesterol, HDL, Single Nucleotide, Cholesterol, LDL, Middle Aged, Lipid Metabolism, eye diseases, Cholesterol Ester Transfer Proteins, Cholesterol, Cross-Sectional Studies, lipids (amino acids, peptides, and proteins), Female, sense organs
Abstract

Purpose Genetic and epidemiologic studies have shown that lipid genes and high-density lipoproteins (HDLs) are implicated in age-related macular degeneration (AMD). We studied circulating lipid levels in relationship to AMD in a large European dataset. Design Pooled analysis of cross-sectional data. Participants Individuals (N = 30 953) aged 50 years or older participating in the European Eye Epidemiology (E3) consortium and 1530 individuals from the Rotterdam Study with lipid subfraction data. Methods AMD features were graded on fundus photographs using the Rotterdam classification. Routine blood lipid measurements, genetics, medication, and potential confounders were extracted from the E3 database. In a subgroup of the Rotterdam Study, lipid subfractions were identified by the Nightingale biomarker platform. Random-intercepts mixed-effects models incorporating confounders and study site as a random effect were used to estimate associations. Main Outcome Measures AMD features and stage; lipid measurements. Results HDL was associated with an increased risk of AMD (odds ratio [OR], 1.21 per 1-mmol/l increase; 95% confidence interval [CI], 1.14–1.29), whereas triglycerides were associated with a decreased risk (OR, 0.94 per 1-mmol/l increase; 95% CI, 0.91–0.97). Both were associated with drusen size. Higher HDL raised the odds of larger drusen, whereas higher triglycerides decreases the odds. LDL cholesterol reached statistical significance only in the association with early AMD (P = 0.045). Regarding lipid subfractions, the concentration of extra-large HDL particles showed the most prominent association with AMD (OR, 1.24; 95% CI, 1.10–1.40). The cholesteryl ester transfer protein risk variant (rs17231506) for AMD was in line with increased HDL levels (P = 7.7 × 10–7), but lipase C risk variants (rs2043085, rs2070895) were associated in an opposite way (P = 1.0 × 10–6 and P = 1.6 × 10–4). Conclusions Our study suggested that HDL cholesterol is associated with increased risk of AMD and that triglycerides are negatively associated. Both show the strongest association with early AMD and drusen. Extra-large HDL subfractions seem to be drivers in the relationship with AMD, and variants in lipid genes play a more ambiguous role in this association. Whether systemic lipids directly influence AMD or represent lipid metabolism in the retina remains to be answered.

Published
2018

44. Kardiologie

Author

Mathey, D. G., Kuck, K. H., Schofer, J., Krebber, H. J., Montz, R., Rodewald, G., Bleifeld, W., Eichstädt, H., Rutsch, W., Botsch, H., Felix, R., Schmutzler, H., Hofmann, M., Schuler, G., Schwarz, F., Mäurer, W., Mehmel, H., Senges, J., Tillmanns, H., Kübler, W., von Olshausen, K., Mehmel, H. C., Zimmermann, R., Harenberg, J., Kandler, J., Rebmann, T., Neuhaus, K. L., Tebbe, U., Sauer, G., Köstering, H., Kreuzer, H., Genth, K., Wetzel, E., Heene, D. L., Kober, G., Scherer, D., Hopf, R., Dowinski, S., Schmidt-Moritz, A., Kaltenbach, M., Schnellbacher, K., Roskamm, H., Beck, O. A., Steckmann, E., Hochrein, H., Weiß, B., Donat, K., Ziegler, W. J., Dirschinger, J., Fleck, E., Brügmann, U., Redl, A., Rudolph, W., Schanzenbächer, P., Liebau, G., Deeg, P., Kochsiek, K., Jansen, W., Osterspey, A., Tauchert, M., Schell, U., Schmid, G., Fuchs, M., Schulz, V., Kipshidze, N. N., Chapidze, G. E., Blasini, R., Froer, K. L., Wemper, J., Behrenbeck, D. W., Hombach, V., Hilger, H. H., Droste, C., Gohlke-Bärwolf, A., Stürzenhofecker, P., Samek, L., Betz, P., Schmuziger, M., Deist, H., Wüsten, B., Schaper, W., Gottwik, M.-G., Puschmann, S., Neumann, F., Farohs, B., Gottwik, M., Bertel, O., Burkart, F., Ritz, R., Baitsch, G., Gilfrich, H. J., Schuster, C. J., Kremer, G., Langenstein, B. A., Hanrath, P., Hall, D., Ibrahim, Z., Meinertz, T., Schmitt, B., Kasper, W., Treese, N., Rückel, A., Zehender, M., Hofmann, T., Pop, T., Bethge, K.-P., Lichtlen, P. R., Kotzur, J., Kuebart, I., Theisen, F., Haufe, M., Theisen, K., Weber, M., Jahrmärker, H., Thormann, J., Schlepper, M., Kramer, W., Neuss, H., Wester, H.-A., Mouselimis, N., Steinbeck, G., Manz, M., Lüderitz, B., Höpp, H.-W., Braun, V., Djonlagic, H., Potratz, J., Lander, B., Hoffmann, J., Dageförde, J., Diedrich, K.-W., Wege, G., Haerten, K., Borggrefe, M., Breithardt, G., Weyers, F. J., Abendroth, R.-R., Heuer, H., Gülker, H., Thale, J., Meyer, M., Weiß, U., Bender, F., Bubenheimer, P., Görnandt, L., Erbei, R., Schweizer, P., Lambertz, H., Langen, H.-J., Meyer, J., Effert, S., and Schlegel, Bernhard, editor

Published
1982
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47. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future

Author

Colijn, J.M. (Johanna), Buitendijk, G.H.S. (Gabrielle), Prokofyeva, E. (Elena), Alves, D. (Dalila), Cachulo, M.L. (Maria L.), Khawaja, A.P. (Anthony), Cougnard-Grégoire, A. (Audrey), Merle, B.M.J. (Bénédicte M.J.), Korb, C. (Christina), Erke, M.G. (Maja Gran), Bron, A. (Alain), Anastasopoulos, E. (Eleftherios), Meester-Smoor, M.A. (Magda), Segato, T. (Tatiana), Piermarocchi, S. (Stefano), Jong, P.T.V.M. (Paulus) de, Vingerling, J.R. (Hans), Topouzis, F. (Fotis), Creuzot-Garcher, C. (Catherine), Bertelsen, G. (Geir), Pfeiffer, A.F.H. (Andreas), Fletcher, A.E. (Astrid E.), Foster, P.J. (Paul), Silva, R. (Rufino), Korobelnik, J.-F. (Jean-François), Delcourt, C. (Cécile), Klaver, C.C.W. (Caroline), Ajana, S. (Soufiane), Arango-Gonzalez, B. (Blanca), Arndt, V. (Verena), Bhatia, V. (Vaibhav), Bhattacharya, S.S. (Shomi S.), Biarnés, M. (Marc), Borrell, A. (Anna), Bühren, S. (Sebastian), Calado, S.M. (Sofia M.), Colijn, J.M. (Johanna M.), Dammeier, S. (Sascha), Jong, E.K. (Eiko) de, De la Cerda, B. (Berta), den Hollander, A.I. (Anneke I.), Diaz-Corrales, F.J. (Francisco J.), Diether, S. (Sigrid), Emri, E. (Eszter), Endermann, T. (Tanja), Ferraro, L.L. (Lucia L.), Garcia, M. (Míriam), Heesterbeek, T.J. (Thomas J.), Honisch, S. (Sabina), Hoyng, C.B. (Carel B.), Kersten, E. (Eveline), Kilger, E. (Ellen), Klaver, C.C.W. (Caroline C.W.), Langen, H. (Hanno), Lengyel, I. (Imre), Luthert, P. (Phil), Maugeais, C. (Cyrille), Meester-Smoor, M. (Magda), Monés, J. (Jordi), Nogoceke, E. (Everson), Peto, T. (Tunde), Pool, F.M. (Frances M.), Rodríguez, E. (Eduardo), Ueffing, M. (Marius), Ulrich Bartz-Schmidt, K.U. (Karl U.), van Leeuwen, E.M. (Elisabeth M.), Verzijden, T. (Timo), Zumbansen, M. (Markus), Acar, N. (Niyazi), Anastosopoulos, E. (Eleftherios), Azuara-Blanco, A. (Augusto), Bergen, A.A.B. (Arthur), Binquet, C. (Christine), Bird, A.C. (Alan), Bretillon, L. (Lionel), Buitendijk, G. (Gabrielle), Cachulo, M.L. (Maria Luz), Chakravarthy, U. (Usha), Chan, M. (Michelle), Chang, P. (Petrus), Colijn, J. (Johanna), Cumberland, P. (Phillippa), Cunha-Vaz, J. (José), Daien, V. (Vincent), Deak, G. (Gabor), Delyfer, M.-N. (Marie-Noëlle), Hollander, A.I. (Anneke), Dietzel, M. (Martha), Fauser, S. (Sascha), Finger, R. (Robert), Fletcher, A. (Astrid), Foster, P.J. (Paul J.), Founti, P. (Panayiota), Göbel, A. (Arno), Gorgels, T.G.M.F. (Theo), Grauslund, J. (Jakob), Grus, F. (Franz), Hammond, C.J. (Christopher), Helmer, C. (Catherine), Hense, H.-W. (Hans-Werner), Hermann, M. (Manuel), Hoehn, R. (René), Hogg, R. (Ruth), Holz, F.G. (Frank), Hoyng, C.B. (Carel), Jansonius, N.M. (Nomdo), Janssen, S.F. (Sarah), Khawaja, A. (Anthony), Lamparter, J. (Julia), Le Goff, M. (Mélanie), Leal, S. (Sergio), Lechanteur, Y.T.E. (Yara T. E.), Lehtimäki, T. (Terho), Lotery, A.J. (Andrew), Leung, I. (Irene), Mauschitz, M. (Matthias), Merle, B. (Bénédicte), Meyer zu Westrup, V. (Verena), Midena, E. (Edoardo), Miotto, S. (Stefania), Mirshahi, A. (Alireza), Mohan-Saïd, S. (Sadek), Mueller, M. (Michael), Muldrew, A. (Alyson), Nunes, S. (Sandrina), Oexle, K. (Konrad), Peto, T. (Tünde), Rahi, J. (Jugnoo), Raitakari, O. (Olli), Ribeiro, L. (Luisa), Rougier, M.-B. (Marie-Bénédicte), Sahel, J.-A. (José-Alain), Salonikiou, A. (Aggeliki), Sanchez, C. (Clarisa), Schmitz-Valckenberg, S. (Steffen), Schweitzer, C.M.C. (C. M C), Shehata, J. (Jasmin), Silvestri, G. (Giuliana), Simader, C. (Christian), Souied, E.H. (Eric), Springelkamp, H. (Henriët), Tapp, R. (Robyn), Verhoeven, V. (Virginie), Von Hanno, T. (Therese), Vujosevic, S. (Stela), Williams, K. (Katie), Wolfram, C. (Christian), Yip, J. (Jennifer), Zerbib, J. (Jennyfer), Zwiener, I. (Isabella), Colijn, J.M. (Johanna), Buitendijk, G.H.S. (Gabrielle), Prokofyeva, E. (Elena), Alves, D. (Dalila), Cachulo, M.L. (Maria L.), Khawaja, A.P. (Anthony), Cougnard-Grégoire, A. (Audrey), Merle, B.M.J. (Bénédicte M.J.), Korb, C. (Christina), Erke, M.G. (Maja Gran), Bron, A. (Alain), Anastasopoulos, E. (Eleftherios), Meester-Smoor, M.A. (Magda), Segato, T. (Tatiana), Piermarocchi, S. (Stefano), Jong, P.T.V.M. (Paulus) de, Vingerling, J.R. (Hans), Topouzis, F. (Fotis), Creuzot-Garcher, C. (Catherine), Bertelsen, G. (Geir), Pfeiffer, A.F.H. (Andreas), Fletcher, A.E. (Astrid E.), Foster, P.J. (Paul), Silva, R. (Rufino), Korobelnik, J.-F. (Jean-François), Delcourt, C. (Cécile), Klaver, C.C.W. (Caroline), Ajana, S. (Soufiane), Arango-Gonzalez, B. (Blanca), Arndt, V. (Verena), Bhatia, V. (Vaibhav), Bhattacharya, S.S. (Shomi S.), Biarnés, M. (Marc), Borrell, A. (Anna), Bühren, S. (Sebastian), Calado, S.M. (Sofia M.), Colijn, J.M. (Johanna M.), Dammeier, S. (Sascha), Jong, E.K. (Eiko) de, De la Cerda, B. (Berta), den Hollander, A.I. (Anneke I.), Diaz-Corrales, F.J. (Francisco J.), Diether, S. (Sigrid), Emri, E. (Eszter), Endermann, T. (Tanja), Ferraro, L.L. (Lucia L.), Garcia, M. (Míriam), Heesterbeek, T.J. (Thomas J.), Honisch, S. (Sabina), Hoyng, C.B. (Carel B.), Kersten, E. (Eveline), Kilger, E. (Ellen), Klaver, C.C.W. (Caroline C.W.), Langen, H. (Hanno), Lengyel, I. (Imre), Luthert, P. (Phil), Maugeais, C. (Cyrille), Meester-Smoor, M. (Magda), Monés, J. (Jordi), Nogoceke, E. (Everson), Peto, T. (Tunde), Pool, F.M. (Frances M.), Rodríguez, E. (Eduardo), Ueffing, M. (Marius), Ulrich Bartz-Schmidt, K.U. (Karl U.), van Leeuwen, E.M. (Elisabeth M.), Verzijden, T. (Timo), Zumbansen, M. (Markus), Acar, N. (Niyazi), Anastosopoulos, E. (Eleftherios), Azuara-Blanco, A. (Augusto), Bergen, A.A.B. (Arthur), Binquet, C. (Christine), Bird, A.C. (Alan), Bretillon, L. (Lionel), Buitendijk, G. (Gabrielle), Cachulo, M.L. (Maria Luz), Chakravarthy, U. (Usha), Chan, M. (Michelle), Chang, P. (Petrus), Colijn, J. (Johanna), Cumberland, P. (Phillippa), Cunha-Vaz, J. (José), Daien, V. (Vincent), Deak, G. (Gabor), Delyfer, M.-N. (Marie-Noëlle), Hollander, A.I. (Anneke), Dietzel, M. (Martha), Fauser, S. (Sascha), Finger, R. (Robert), Fletcher, A. (Astrid), Foster, P.J. (Paul J.), Founti, P. (Panayiota), Göbel, A. (Arno), Gorgels, T.G.M.F. (Theo), Grauslund, J. (Jakob), Grus, F. (Franz), Hammond, C.J. (Christopher), Helmer, C. (Catherine), Hense, H.-W. (Hans-Werner), Hermann, M. (Manuel), Hoehn, R. (René), Hogg, R. (Ruth), Holz, F.G. (Frank), Hoyng, C.B. (Carel), Jansonius, N.M. (Nomdo), Janssen, S.F. (Sarah), Khawaja, A. (Anthony), Lamparter, J. (Julia), Le Goff, M. (Mélanie), Leal, S. (Sergio), Lechanteur, Y.T.E. (Yara T. E.), Lehtimäki, T. (Terho), Lotery, A.J. (Andrew), Leung, I. (Irene), Mauschitz, M. (Matthias), Merle, B. (Bénédicte), Meyer zu Westrup, V. (Verena), Midena, E. (Edoardo), Miotto, S. (Stefania), Mirshahi, A. (Alireza), Mohan-Saïd, S. (Sadek), Mueller, M. (Michael), Muldrew, A. (Alyson), Nunes, S. (Sandrina), Oexle, K. (Konrad), Peto, T. (Tünde), Rahi, J. (Jugnoo), Raitakari, O. (Olli), Ribeiro, L. (Luisa), Rougier, M.-B. (Marie-Bénédicte), Sahel, J.-A. (José-Alain), Salonikiou, A. (Aggeliki), Sanchez, C. (Clarisa), Schmitz-Valckenberg, S. (Steffen), Schweitzer, C.M.C. (C. M C), Shehata, J. (Jasmin), Silvestri, G. (Giuliana), Simader, C. (Christian), Souied, E.H. (Eric), Springelkamp, H. (Henriët), Tapp, R. (Robyn), Verhoeven, V. (Virginie), Von Hanno, T. (Therese), Vujosevic, S. (Stela), Williams, K. (Katie), Wolfram, C. (Christian), Yip, J. (Jennifer), Zerbib, J. (Jennyfer), and Zwiener, I. (Isabella)

Abstract

Purpose Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. Design Meta-analysis of prevalence data. Participants A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe. Methods AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV). Main Outcome Measures Prevalence of early and late AMD, BCVA, and number of AMD cases. Results Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1%–5.0%) in those aged 55–59 years to 17.6% (95% C

Published
2017
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48. Het effect van FES-fiets training bij een dwarslaesie

Author

Gerrits, H.L., Haan, A. de, Kuppevelt, H.J.M. van, Langen, H. van, Hopman, M.T.E., and Kinesiology

Subjects
Human skeletal muscle plasticity studied using chronic electrical stimulation in individuals with spinal cord damage, Toepasbaarheid van echo-Doppler onderzoek om longitudinale veranderingen in anatomie en hemodynamiek van het vaatstelsel kwantitatief vast te leggen bij verschillende risicogroepen, Applications of echo-Doppler measurements to quantify longitudinal changes in anatomy and hemodynamics in the vascular system in different risk groups, Spierplasticiteit van de onderste extremiteiten bij mensen met ruggemerg letsel
Abstract

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Published
2000

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