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5. Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence

Author

Parkash, J, Messina, A, Langlet, F, Cimino, I, Loyens, A, Mazur, D, Gallet, S, Balland, E, Malone, SA, Pralong, F, Cagnoni, G, Schellino, R, De Marchis, S, Mazzone, M, Pasterkamp, RJ, Tamagnone, L, Prevot, V, Giacobini, P, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Institut de médecine predictive et de recherche thérapeutique (IMPRT), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Faculty of Biology and Medicine [Lausanne, Switzerland], Université de Lausanne (UNIL), Candiolo Cancer Institute [Candiolo, Italie], Università degli studi di Torino (UNITO), Vesalius Research Center [Louvain, Belgique], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Brain Centre Rudolf Magnus [Utrecht], University Medical Center [Utrecht], Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Université de Lille-UNICANCER-Université de Lille-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lausanne = University of Lausanne (UNIL), Università degli studi di Torino = University of Turin (UNITO), and Prevot, Vincent

Subjects
endocrine system, Chemistry(all), Ovariectomy, Blotting, Western, Fluorescent Antibody Technique, Enzyme-Linked Immunosorbent Assay, PLEXINC1, Semaphorins, Physics and Astronomy(all), Real-Time Polymerase Chain Reaction, Article, ACTIN, AXON GUIDANCE, Rats, Sprague-Dawley, Mice, Antigens, CD, Image Processing, Computer-Assisted, Journal Article, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Progesterone, SEMAPHORIN 7A, GENE-EXPRESSION, Analysis of Variance, Science & Technology, Neuronal Plasticity, RECEPTOR, Estradiol, Biochemistry, Genetics and Molecular Biology(all), Research Support, Non-U.S. Gov't, Median Eminence, TGF-BETA, Flow Cytometry, Immunohistochemistry, GNRH NEURONS, Rats, Multidisciplinary Sciences, ESTROUS-CYCLE, HORMONE NERVE-TERMINALS, GONADOTROPIN, GnRH, Science & Technology - Other Topics, RAT, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Settore BIO/17 - ISTOLOGIA, Neuroglia
Abstract

Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic–pituitary–gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle., Reproduction in mammals is dependent on the function of specific neurons that secrete gonadotropin-releasing hormone (GnRH) and project their axons to the median eminence (ME) of the hypothalamus. Here the authors show that Semaphorin7A signaling plays a role in mediating the plasticity of GnRH axon terminals and tanycytes in the ME.

Published
2020
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6. Tanycyte Gene Expression Dynamics in the Regulation of Energy Homeostasis

Author

Langlet, F.

Subjects
tanycyte, metabolic sensing, gene expression, energy balance, hypothalamus
Abstract

Animal survival relies on a constant balance between energy supply and energy expenditure, which is controlled by several neuroendocrine functions that integrate metabolic information and adapt the response of the organism to physiological demands. Polarized ependymoglial cells lining the floor of the third ventricle and sending a single process within metabolic hypothalamic parenchyma, tanycytes are henceforth described as key components of the hypothalamic neural network controlling energy balance. Their strategic position and peculiar properties convey them diverse physiological functions ranging from blood/brain traffic controllers, metabolic modulators, and neural stem/progenitor cells. At the molecular level, these functions rely on an accurate regulation of gene expression. Indeed, tanycytes are characterized by their own molecular signature which is mostly associated to their diverse physiological functions, and the detection of variations in nutrient/hormone levels leads to an adequate modulation of genetic profile in order to ensure energy homeostasis. The aim of this review is to summarize recent knowledge on the nutritional control of tanycyte gene expression.

Published
2019

7. Planck pre-launch status: The Planck mission

Author

Tauber, J, Mandolesi, N, Puget, J, Banos, T, Bersanelli, M, Bouchet, F, Butler, R, Charra, J, Crone, G, Dodsworth, J, Efstathiou, G, Gispert, R, Guyot, G, Gregorio, A, Juillet, J, Lamarre, J, Laureijs, R, Lawrence, C, NØRGAARD NIELSEN, H, Passvogel, T, Reix, J, Texier, D, Vibert, L, Zacchei, A, Ade, P, Aghanim, N, Aja, B, Alippi, E, Aloy, L, Armand, P, Arnaud, M, Arondel, A, ARREOLA VILLANUEVA, A, Artal, E, Artina, E, Arts, A, Ashdown, M, Aumont, J, Azzaro, M, Bacchetta, A, Baccigalupi, C, Baker, M, Balasini, M, Balbi, A, Banday, A, Barbier, G, Barreiro, R, Bartelmann, M, Battaglia, P, Battaner, E, Benabed, K, Beney, J, Beneyton, R, Bennett, K, Benoit, A, Bernard, J, Bhandari, P, Bhatia, R, Biggi, M, Biggins, R, Billig, G, Blanc, Y, Blavot, H, Bock, J, Bonaldi, A, Bond, R, Bonis, J, Borders, J, Borrill, J, Boschini, L, Boulanger, F, Bouvier, J, Bouzit, M, Bowman, R, Bréelle, E, Bradshaw, T, Braghin, M, Bremer, M, Brienza, D, Broszkiewicz, D, Burigana, C, Burkhalter, M, Cabella, P, Cafferty, T, Cairola, M, Caminade, S, Camus, P, Cantalupo, C, Cappellini, B, Cardoso, J, Carr, R, Catalano, A, Cayón, L, Cesa, M, Chaigneau, M, Challinor, A, Chamballu, A, Chambelland, J, Charra, M, Chiang, L, Chlewicki, G, Christensen, P, Church, S, Ciancietta, E, Cibrario, M, Cizeron, R, Clements, D, Collaudin, B, Colley, J, Colombi, S, Colombo, A, Colombo, F, Corre, O, Couchot, F, Cougrand, B, Coulais, A, Couzin, P, Crane, B, Crill, B, Crook, M, Crumb, D, Cuttaia, F, Dörl, U, DA SILVA, P, Daddato, R, Damasio, C, Danese, L, D'Aquino, G, D'Arcangelo, O, Dassas, K, Davies, R, Davies, W, Davis, R, DE BERNARDIS, P, DE CHAMBURE, D, DE GASPERIS, G, DE LA FUENTE, M, DE PACO, P, DE ROSA, A, DE TROIA, G, DE ZOTTI, G, Dehamme, M, Delabrouille, J, Delouis, J, Désert, F, DI GIROLAMO, G, Dickinson, C, Doelling, E, Dolag, K, Domken, I, Douspis, M, Doyle, D, Du, S, Dubruel, D, Dufour, C, Dumesnil, C, Dupac, X, Duret, P, Eder, C, Elfving, A, Enlin, T, Eng, P, English, K, Eriksen, H, Estaria, P, Falvella, M, Ferrari, F, Finelli, F, Fishman, A, Fogliani, S, Foley, S, Fonseca, A, Forma, G, Forni, O, Fosalba, P, Fourmond, J, Frailis, M, Franceschet, C, Franceschi, E, François, S, Frerking, M, GÓMEZ REÑASCO, M, Górski, K, Gaier, T, Galeotta, S, Ganga, K, GARCÍA LÁZARO, J, Garnica, A, Gaspard, M, Gavila, E, Giard, M, Giardino, G, Gienger, G, GIRAUD HERAUD, Y, Glorian, J, Griffin, M, Gruppuso, A, Guglielmi, L, Guichon, D, Guillaume, B, Guillouet, P, Haissinski, J, Hansen, F, Hardy, J, Harrison, D, Hazell, A, Hechler, M, Heckenauer, V, Heinzer, D, Hell, R, HENROT VERSILLÉ, S, HERNÁNDEZ MONTEAGUDO, C, Herranz, D, Herreros, J, Hervier, V, Heske, A, Heurtel, A, Hildebrandt, S, Hills, R, Hivon, E, Hobson, M, Hollert, D, Holmes, W, Hornstrup, A, Hovest, W, Hoyland, R, Huey, G, Huffenberger, K, Hughes, N, Israelsson, U, Jackson, B, Jaffe, A, Jaffe, T, Jagemann, T, Jessen, N, Jewell, J, Jones, W, Juvela, M, Kaplan, J, Karlman, P, Keck, F, Keihänen, E, King, M, Kisner, T, Kletzkine, P, Kneissl, R, Knoche, J, Knox, L, Koch, T, Krassenburg, M, KURKI SUONIO, H, Lähteenmäki, A, Lagache, G, Lagorio, E, Lami, P, Lande, J, Lange, A, Langlet, F, Lapini, R, Lapolla, M, Lasenby, A, LE JEUNE, M, Leahy, J, Lefebvre, M, Legrand, F, LE MEUR, G, Leonardi, R, Leriche, B, Leroy, C, Leutenegger, P, Levin, S, Lilje, P, Lindensmith, C, LINDEN VØRNLE, M, Loc, A, Longval, Y, Lubin, P, Luchik, T, Luthold, I, MACIAS PEREZ, J, Maciaszek, T, Mactavish, C, Madden, S, Maffei, B, Magneville, C, Maino, D, Mambretti, A, Mansoux, B, Marchioro, D, Maris, M, Marliani, F, Marrucho, J, MARTÍ CANALES, J, MARTÍNEZ GONZÁLEZ, E, MARTÍN POLEGRE, A, Martin, P, Marty, C, Marty, W, Masi, S, Massardi, M, Matarrese, S, Matthai, F, Mazzotta, P, Mcdonald, A, Mcgrath, P, Mediavilla, A, Meinhold, P, Mélin, J, Melot, F, Mendes, L, Mennella, A, Mervier, C, Meslier, L, Miccolis, M, MIVILLE DESCHENES, M, Moneti, A, Montet, D, Montier, L, Mora, J, Morgante, G, Morigi, G, Morinaud, G, Morisset, N, Mortlock, D, Mottet, S, Mulder, J, Munshi, D, Murphy, A, Murphy, P, Musi, P, Narbonne, J, Naselsky, P, Nash, A, Nati, F, Natoli, P, Netterfield, B, Newell, J, Nexon, M, Nicolas, C, Nielsen, P, Ninane, N, Noviello, F, Novikov, D, Novikov, I, O'Dwyer, I, Oldeman, P, Olivier, P, Ouchet, L, Oxborrow, C, PÉREZ CUEVAS, L, Pagan, L, Paine, C, Pajot, F, Paladini, R, Pancher, F, Panh, J, Parks, G, Parnaudeau, P, Partridge, B, Parvin, B, Pascual, J, Pasian, F, Pearson, D, Pearson, T, Pecora, M, Perdereau, O, Perotto, L, Perrotta, F, Piacentini, F, Piat, M, Pierpaoli, E, Piersanti, O, Plaige, E, Plaszczynski, S, Platania, P, Pointecouteau, E, Polenta, G, Ponthieu, N, Popa, L, Poulleau, G, Poutanen, T, Prézeau, G, Pradell, L, Prina, M, Prunet, S, Rachen, J, Rambaud, D, Rame, F, Rasmussen, I, Rautakoski, J, Reach, W, Rebolo, R, Reinecke, M, Reiter, J, Renault, C, Ricciardi, S, Rideau, P, Riller, T, Ristorcelli, I, Riti, J, Rocha, G, Roche, Y, Pons, R, Rohlfs, R, Romero, D, Roose, S, Rosset, C, Rouberol, S, ROWAN ROBINSON, M, RUBIÑO MARTÍN, J, Rusconi, P, Rusholme, B, Salama, M, Salerno, E, Sandri, M, Santos, D, Sanz, J, Sauter, L, Sauvage, F, Savini, G, Schmelzel, M, Schnorhk, A, Schwarz, W, Scott, D, Seiffert, M, Shellard, P, Shih, C, Sias, M, Silk, J, Silvestri, R, Sippel, R, Smoot, G, Starck, J, Stassi, P, Sternberg, J, Stivoli, F, Stolyarov, V, Stompor, R, Stringhetti, L, Strommen, D, Stute, T, Sudiwala, R, Sugimura, R, Sunyaev, R, Sygnet, J, Türler, M, Taddei, E, Tallon, J, Tamiatto, C, Taurigna, M, Taylor, D, Terenzi, L, Thuerey, S, Tillis, J, Tofani, G, Toffolatti, L, Tommasi, E, Tomasi, M, Tonazzini, E, Torre, J, Tosti, S, Touze, F, Tristram, M, Tuovinen, J, Tuttlebee, M, Umana, G, Valenziano, L, Vallée, D, VAN DER VLIS, M, VAN LEEUWEN, F, Vanel, J, VAN TENT, B, Varis, J, Vassallo, E, Vescovi, C, Vezzu, F, Vibert, D, Vielva, P, Vierra, J, Villa, F, Vittorio, N, Vuerli, C, Wade, L, Walker, A, Wandelt, B, Watson, C, Werner, D, White, M, White, S, Wilkinson, A, Wilson, P, Woodcraft, A, Yoffo, B, Yun, M, Yurchenko, V, Yvon, D, Zhang, B, Zimmermann, O, Zonca, A, Zorita, D, TAUBER J. A, MANDOLESI N, PUGET J. L, BANOS T, BERSANELLI M, BOUCHET F. R, BUTLER R. C, CHARRA J, CRONE G, DODSWORTH J, EFSTATHIOU G, GISPERT R, GUYOT G, GREGORIO A, JUILLET J. J, LAMARRE J. M, LAUREIJS R. J, LAWRENCE C. R, NØRGAARD NIELSEN H. U, PASSVOGEL T, REIX J. M, TEXIER D, VIBERT L, ZACCHEI A, ADE P. A. R, AGHANIM N, AJA B, ALIPPI E, ALOY L, ARMAND P, ARNAUD M, ARONDEL A, ARREOLA VILLANUEVA A, ARTAL E, ARTINA E, ARTS A, ASHDOWN M, AUMONT J, AZZARO M, BACCHETTA A, BACCIGALUPI C, BAKER M, BALASINI M, BALBI A, BANDAY A. J, BARBIER G, BARREIRO R. B, BARTELMANN M, BATTAGLIA P, BATTANER E, BENABED K, BENEY J. L, BENEYTON R, BENNETT K, BENOIT A, BERNARD J. P, BHANDARI P, BHATIA R, BIGGI M, BIGGINS R, BILLIG G, BLANC Y, BLAVOT H, BOCK J. J, BONALDI A, BOND R, BONIS J, BORDERS J, BORRILL J, BOSCHINI L, BOULANGER F, BOUVIER J, BOUZIT M, BOWMAN R, BRÉELLE E, BRADSHAW T, BRAGHIN M, BREMER M, BRIENZA, DANIELE, BROSZKIEWICZ D, BURIGANA C, BURKHALTER M, CABELLA, PAOLO, CAFFERTY T, CAIROLA M, CAMINADE S, CAMUS P, CANTALUPO C. M, CAPPELLINI B, CARDOSO J. F, CARR R, CATALANO, Andrea, CAYÓN L, CESA M, CHAIGNEAU M, CHALLINOR A, CHAMBALLU A, CHAMBELLAND J. P, CHARRA M, CHIANG L. Y, CHLEWICKI G, CHRISTENSEN P. R, CHURCH S, CIANCIETTA E, CIBRARIO M, CIZERON R, CLEMENTS D, COLLAUDIN B, COLLEY J. M, COLOMBI S, COLOMBO A, COLOMBO F, CORRE O, COUCHOT F, COUGRAND B, COULAIS A, COUZIN P, CRANE B, CRILL B, CROOK M, CRUMB D, CUTTAIA F, DÖRL U, DA SILVA P, DADDATO R, DAMASIO C, DANESE L, D'AQUINO G, D'ARCANGELO O, DASSAS K, DAVIES R. D, DAVIES W, DAVIS R. J, DE BERNARDIS, Paolo, DE CHAMBURE D, DE GASPERIS G, DE LA FUENTE M. L, DE PACO P, DE ROSA A, DE TROIA, Grazia, DE ZOTTI G, DEHAMME M, DELABROUILLE J, DELOUIS J. M, DÉSERT F. X, DI GIROLAMO G, DICKINSON C, DOELLING E, DOLAG K, DOMKEN I, DOUSPIS M, DOYLE D, DU S, DUBRUEL D, DUFOUR C, DUMESNIL C, DUPAC X, DURET P, EDER C, ELFVING A, ENLIN T. A, ENG P, ENGLISH K, ERIKSEN H. K, ESTARIA P, FALVELLA M. C, FERRARI F, FINELLI F, FISHMAN A, FOGLIANI S, FOLEY S, FONSECA A, FORMA G, FORNI O, FOSALBA P, FOURMOND J. J, FRAILIS M, FRANCESCHET C, FRANCESCHI E, FRANÇOIS S, FRERKING M, GÓMEZ REÑASCO M. F, GÓRSKI K. M, GAIER T. C, GALEOTTA S, GANGA K, GARCÍA LÁZARO J, GARNICA A, GASPARD M, GAVILA E, GIARD M, GIARDINO G, GIENGER G, GIRAUD HERAUD Y, GLORIAN J. M, GRIFFIN M, GRUPPUSO A, GUGLIELMI L, GUICHON D, GUILLAUME B, GUILLOUET P, HAISSINSKI J, HANSEN F. K, HARDY J, HARRISON D, HAZELL A, HECHLER M, HECKENAUER V, HEINZER D, HELL R, HENROT VERSILLÉ S, HERNÁNDEZ MONTEAGUDO C, HERRANZ D, HERREROS J. M, HERVIER V, HESKE A, HEURTEL A, HILDEBRANDT S. R, HILLS R, HIVON E, HOBSON M, HOLLERT D, HOLMES W, HORNSTRUP A, HOVEST W, HOYLAND R. J, HUEY G, HUFFENBERGER K. M, HUGHES N, ISRAELSSON U, JACKSON B, JAFFE A, JAFFE T. R, JAGEMANN T, JESSEN N. C, JEWELL J, JONES W, JUVELA M, KAPLAN J, KARLMAN P, KECK F, KEIHÄNEN E, KING M, KISNER T. S, KLETZKINE P, KNEISSL R, KNOCHE J, KNOX L, KOCH T, KRASSENBURG M, KURKI SUONIO H, LÄHTEENMÄKI A, LAGACHE G, LAGORIO E, LAMI P, LANDE J, LANGE A, LANGLET F, LAPINI R, LAPOLLA M, LASENBY A, LE JEUNE M, LEAHY J. P, LEFEBVRE M, LEGRAND F, LE MEUR G, LEONARDI R, LERICHE B, LEROY C, LEUTENEGGER P, LEVIN S. M, LILJE P. B, LINDENSMITH C, LINDEN VØRNLE M, LOC A, LONGVAL Y, LUBIN P. M, LUCHIK T, LUTHOLD I, MACIAS PEREZ J. F, MACIASZEK T, MACTAVISH C, MADDEN S, MAFFEI B, MAGNEVILLE C, MAINO D, MAMBRETTI A, MANSOUX B, MARCHIORO D, MARIS M, MARLIANI F, MARRUCHO J. C, MARTÍ CANALES J, MARTÍNEZ GONZÁLEZ E, MARTÍN POLEGRE A, MARTIN P, MARTY C, MARTY W, MASI, Silvia, MASSARDI M, MATARRESE S, MATTHAI F, MAZZOTTA P, MCDONALD A, MCGRATH P, MEDIAVILLA A, MEINHOLD P. R, MÉLIN J. B, MELOT F, MENDES L, MENNELLA A, MERVIER C, MESLIER L, MICCOLIS M, MIVILLE DESCHENES M. A, MONETI A, MONTET D, MONTIER L, MORA J, MORGANTE G, MORIGI G, MORINAUD G, MORISSET N, MORTLOCK D, MOTTET S, MULDER J, MUNSHI D, MURPHY A, MURPHY P, MUSI P, NARBONNE J, NASELSKY P, NASH A, NATI, FEDERICO, NATOLI P, NETTERFIELD B, NEWELL J, NEXON M, NICOLAS C, NIELSEN P. H, NINANE N, NOVIELLO F, NOVIKOV D, NOVIKOV I, O'DWYER I. J, OLDEMAN P, OLIVIER P, OUCHET L, OXBORROW C. A, PÉREZ CUEVAS L, PAGAN L, PAINE C, PAJOT F, PALADINI R, PANCHER F, PANH J, PARKS G, PARNAUDEAU P, PARTRIDGE B, PARVIN B, PASCUAL J. P, PASIAN F, PEARSON D. P, PEARSON T, PECORA M, PERDEREAU O, PEROTTO L, PERROTTA F, PIACENTINI, Francesco, PIAT M, PIERPAOLI E, PIERSANTI O, PLAIGE E, PLASZCZYNSKI S, PLATANIA P, POINTECOUTEAU E, POLENTA, GIANLUCA, PONTHIEU N, POPA L, POULLEAU G, POUTANEN T, PRÉZEAU G, PRADELL L, PRINA M, PRUNET S, RACHEN J. P, RAMBAUD D, RAME F, RASMUSSEN I, RAUTAKOSKI J, REACH W. T, REBOLO R, REINECKE M, REITER J, RENAULT C, RICCIARDI, Sara, RIDEAU P, RILLER T, RISTORCELLI I, RITI J. B, ROCHA G, ROCHE Y, PONS R, ROHLFS R, ROMERO D, ROOSE S, ROSSET C, ROUBEROL S, ROWAN ROBINSON M, RUBIÑO MARTÍN J. A, RUSCONI P, RUSHOLME B, SALAMA M, SALERNO E, SANDRI M, SANTOS D, SANZ J. L, SAUTER L, SAUVAGE F, SAVINI, Giorgio, SCHMELZEL M, SCHNORHK A, SCHWARZ W, SCOTT D, SEIFFERT M. D, SHELLARD P, SHIH C, SIAS M, SILK J. I, SILVESTRI R, SIPPEL R, SMOOT G. F, STARCK J. L, STASSI P, STERNBERG J, STIVOLI, federico, STOLYAROV V, STOMPOR R, STRINGHETTI L, STROMMEN D, STUTE T, SUDIWALA R, SUGIMURA R, SUNYAEV R, SYGNET J. F, TÜRLER M, TADDEI E, TALLON J, TAMIATTO C, TAURIGNA M, TAYLOR D, TERENZI L, THUEREY S, TILLIS J, TOFANI G, TOFFOLATTI L, TOMMASI E, TOMASI M, TONAZZINI E, TORRE J. P, TOSTI S, TOUZE F, TRISTRAM M, TUOVINEN J, TUTTLEBEE M, UMANA G, VALENZIANO L, VALLÉE D, VAN DER VLIS M, VAN LEEUWEN F, VANEL J. C, VAN TENT B, VARIS J, VASSALLO E, VESCOVI C, VEZZU F, VIBERT D, VIELVA P, VIERRA J, VILLA F, VITTORIO N, VUERLI C, WADE L. A, WALKER A. R, WANDELT B. D, WATSON C, WERNER D, WHITE M, WHITE S. D. M, WILKINSON A, WILSON P, WOODCRAFT A, YOFFO B, YUN M, YURCHENKO V, YVON D, ZHANG B, ZIMMERMANN O, ZONCA A, ZORITA D., Tauber, J, Mandolesi, N, Puget, J, Banos, T, Bersanelli, M, Bouchet, F, Butler, R, Charra, J, Crone, G, Dodsworth, J, Efstathiou, G, Gispert, R, Guyot, G, Gregorio, A, Juillet, J, Lamarre, J, Laureijs, R, Lawrence, C, NØRGAARD NIELSEN, H, Passvogel, T, Reix, J, Texier, D, Vibert, L, Zacchei, A, Ade, P, Aghanim, N, Aja, B, Alippi, E, Aloy, L, Armand, P, Arnaud, M, Arondel, A, ARREOLA VILLANUEVA, A, Artal, E, Artina, E, Arts, A, Ashdown, M, Aumont, J, Azzaro, M, Bacchetta, A, Baccigalupi, C, Baker, M, Balasini, M, Balbi, A, Banday, A, Barbier, G, Barreiro, R, Bartelmann, M, Battaglia, P, Battaner, E, Benabed, K, Beney, J, Beneyton, R, Bennett, K, Benoit, A, Bernard, J, Bhandari, P, Bhatia, R, Biggi, M, Biggins, R, Billig, G, Blanc, Y, Blavot, H, Bock, J, Bonaldi, A, Bond, R, Bonis, J, Borders, J, Borrill, J, Boschini, L, Boulanger, F, Bouvier, J, Bouzit, M, Bowman, R, 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M, HUGHES N, ISRAELSSON U, JACKSON B, JAFFE A, JAFFE T. R, JAGEMANN T, JESSEN N. C, JEWELL J, JONES W, JUVELA M, KAPLAN J, KARLMAN P, KECK F, KEIHÄNEN E, KING M, KISNER T. S, KLETZKINE P, KNEISSL R, KNOCHE J, KNOX L, KOCH T, KRASSENBURG M, KURKI SUONIO H, LÄHTEENMÄKI A, LAGACHE G, LAGORIO E, LAMI P, LANDE J, LANGE A, LANGLET F, LAPINI R, LAPOLLA M, LASENBY A, LE JEUNE M, LEAHY J. P, LEFEBVRE M, LEGRAND F, LE MEUR G, LEONARDI R, LERICHE B, LEROY C, LEUTENEGGER P, LEVIN S. M, LILJE P. B, LINDENSMITH C, LINDEN VØRNLE M, LOC A, LONGVAL Y, LUBIN P. M, LUCHIK T, LUTHOLD I, MACIAS PEREZ J. F, MACIASZEK T, MACTAVISH C, MADDEN S, MAFFEI B, MAGNEVILLE C, MAINO D, MAMBRETTI A, MANSOUX B, MARCHIORO D, MARIS M, MARLIANI F, MARRUCHO J. C, MARTÍ CANALES J, MARTÍNEZ GONZÁLEZ E, MARTÍN POLEGRE A, MARTIN P, MARTY C, MARTY W, MASI, Silvia, MASSARDI M, MATARRESE S, MATTHAI F, MAZZOTTA P, MCDONALD A, MCGRATH P, MEDIAVILLA A, MEINHOLD P. R, MÉLIN J. 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Abstract

The European Space Agency's Planck satellite, launched on 14 May 2009, is the third-generation space experiment in the field of cosmic microwave background (CMB) research. It will image the anisotropies of the CMB over the whole sky, with unprecedented sensitivity (${{\Delta T}\over T}$ ~ 2 × 10-6) and angular resolution (~5 arcmin). Planck will provide a major source of information relevant to many fundamental cosmological problems and will test current theories of the early evolution of the Universe and the origin of structure. It will also address a wide range of areas of astrophysical research related to the Milky Way as well as external galaxies and clusters of galaxies. The ability of Planck to measure polarization across a wide frequency range (30-350 GHz), with high precision and accuracy, and over the whole sky, will provide unique insight, not only into specific cosmological questions, but also into the properties of the interstellar medium. This paper is part of a series which describes the technical capabilities of the Planck scientific payload. It is based on the knowledge gathered during the on-ground calibration campaigns of the major subsystems, principally its telescope and its two scientific instruments, and of tests at fully integrated satellite level. It represents the best estimate before launch of the technical performance that the satellite and its payload will achieve in flight. In this paper, we summarise the main elements of the payload performance, which is described in detail in the accompanying papers. In addition, we describe the satellite performance elements which are most relevant for science, and provide an overview of the plans for scientific operations and data analysis.

Published
2010

8. Evaluation de l'importance et de la diversité de la colonisation par Acinetobacter baumannii chez les animaux d'élevage

Author

Melot, P., Watine, C., Joly-Guillou, Marie-Laure, Eveillard, Matthieu, Pailhories, Hélène, Belmonte, Olivier, Kempf, Marie, Gaultier, Marie-Pierre, Langlet, F., Legendre, P., Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Développement de l'organisation spinale = Development of the spinal cord organization (NPS-10), Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2014

9. Entérobactéries résistantes aux céphalosporines de troisième génération chez les animaux de compagnie sur l'Ile de la Réunion

Author

Pailhories, Hélène, Belmonte, Olivier, Kempf, Marie, Gaultier, Marie-Pierre, Langlet, F., Legendre, P., Melot, P., Watine, C., Joly-Guillou, Marie-Laure, Eveillard, Matthieu, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Développement de l'organisation spinale = Development of the spinal cord organization (NPS-10), Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2014

10. Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.

Author

Parkash, J, Messina, A, Langlet, F, Cimino, I, Loyens, A, Mazur, D, Gallet, S, Balland, E, Malone, Sa, Pralong, F, Cagnoni, G, Schellino, R, De Marchis, S, Mazzone, M, Pasterkamp, Rj, Tamagnone, Luca, Prevot, V, Giacobini, P, Tamagnone L (ORCID:0000-0002-2884-7946), Parkash, J, Messina, A, Langlet, F, Cimino, I, Loyens, A, Mazur, D, Gallet, S, Balland, E, Malone, Sa, Pralong, F, Cagnoni, G, Schellino, R, De Marchis, S, Mazzone, M, Pasterkamp, Rj, Tamagnone, Luca, Prevot, V, Giacobini, P, and Tamagnone L (ORCID:0000-0002-2884-7946)

Abstract

Reproductive competence in mammals depends on the projection of gonadotropin-releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the timely release of GnRH into the hypothalamic-pituitary-gonadal axis. In adult rodents, GnRH neurons and the specialized glial cells named tanycytes periodically undergo cytoskeletal plasticity. However, the mechanisms that regulate this plasticity are still largely unknown. We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively. Moreover, Semaphorin7A expression is regulated during the oestrous cycle by the fluctuating levels of gonadal steroids. Genetic invalidation of Semaphorin7A receptors in mice induces neuronal and glial rearrangements in the ME and abolishes normal oestrous cyclicity and fertility. These results show a role for Semaphorin7A signalling in mediating periodic neuroglial remodelling in the adult ME during the ovarian cycle.

Published
2015

12. A theoretical study of dielectric properties of carbon soot

Author

Langlet F. Moulin S. Picaud M. Devel M.R. Vanacharla , R., Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules ( UTINAM ), and Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC )

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

13. International Conference on Computational Methods in Sciences and Engineering

Author

Langlet F. Moulin S. Picaud M. Devel M. Vanacharla , R., Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules ( UTINAM ), and Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC )

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

14. Planck pre-launch status: The Planck mission

Author

Tauber, J. A., Mandoles, N., Puget, J.-L., Banos, T., Bersanelli, M., Bouchet, F. R., Butler, R. C., Charra, J., Crone, G., Dodsworth, J., Efstathiou, G., Gispert, R., Guyot, G., Gregorio, A., Juillet, J. J., Lamarre, J.-M., Laureijs, R. J., Lawrence, C. R., Nørgaard-Nielsen, Hans Ulrik, Passvogel, T., Reix, J. M., Texier, D., Vilbert, L., Zacchei, A., Ade, P. A. R., Aghanim, N., Aja, B., Alippi, E., Aloy, L., Armand, P., Arnaud, M., Arondel, A., Arreola-Villanueva, A., Artal, E., Artina, E., Arts, A., Ashdown, M., Aumont, J., Azzaro, M., Bacchetta, A., Baccigalupi, C., Baker, M., Balasini, M., Balbi, A., Banday, A. J., Barbier, G., Barreiro, R. B., Bartelmann, M., Battaglia, P., Battaner, E., Benabed, K., Beney, J.-L., Beneyton, R., Bennett, K., Benoit, A., Bernard, J.-P., Bhandari, P., Bhatia, R., Biggi, M., Biggins, R., Billig, G., Blanc, Y., Blavot, H., Bock, J. J., Bonaldi, A., Bond, R., Bonis, J., Borders, J., Borrill, J., Boschini, L., Boulanger, F., Bouvier, J., Bouzit, M., Bowman, R., Bréelle, E., Bradshaw, T., Braghin, M., Bremer, M., Brienza, D., Broszkiewicz, D., Burigana, C., Burkhalter, M., Cabella, P., Cafferty, T., Cairola, M., Caminade, S., Camus, P., Cantalupo, C. M., Cappellini, B., Cardoso, J.-F., Carr, R., Catalono, A., Caýon, L., Cesa, M., Chaigneau, M., Challinor, A., Chamballu, A., Chambelland, J. P., Charra, M., Chiang, L.-Y., Chlewicki, G., Christensen, P. R., Church, S., Ciancietta, E., Cibrario, M., Cizeron, R., Clements, D., Collaudin, B., Colley, J.-M., Colombi, S., Colombo, A., Colombo, F., Corre, O., Couchot, F., Cougrand, B., Coulais, A., Couzin, P., Crane, B., Crill, B., Crook, M., Crumb, D., cuttala, F., Döri, U., da Silva, P., Daddato, R., Damasio, C., Danese, L., d'Aquino, G., D'Arcangelo, O., Dassas, K., Davies, R. D., Davies, W., Davis, R. J., De Bernardis, P., de Chambure, D., de Gasperis, G., De la Fuente, M. L., De Paco, P., De Rosa, A., De Troia, G., De Zotti, G., Dehamme, M., Delabrouille, J., Delouis, J.-M., Désert, F.-X., di Girolamo, G., Dickinson, C., Doelling, E., Dolag, K., Domken, I., Douspis, M., Doyle, D., Du, S., Dubruel, D., Dufour, C., Dumesnil, C., Dupac, X., Duret, P., Eder, C., Elfving, A., Enßlin, T. A., Eng, P., English, K., Eriksen, H. K., Estaria, P., Falvella, M. C., Ferrari, F., Finelli, F., Fishman, A., Fogliani, S., Foley, S., Fonseca, A., Forma, G., Forni, O., Fosalba, P., Fourmond, J.-J., Frallis, M., Franceschet, C., Franceschi, E., François, S., Frerking, M., Gómez-Reñasco, M. F., Gorski, K. M., Gaier, T. C., Galeotta, S., Ganga, K., García Lázaro, J., Garnica, A., Gaspard, M., Gavila, E., Giard, m., Giardino, G., Glenger, G., Giraud-Heraud, Y., Glorian, J.-M., Griffin, M., Gruppuso, A., Guglieimi, L., Guichon, D., Guillaume, B., Guillouet, P., Haissinski, J., Hansen, F. K., Hardy, J., Harrison, D., Hazell, A., Hechler, M., Heckenauer, V., Heinzer, D., Hell, R., Henrot-Versillé, S., Hernándes-Monteagudo, C., Herranz, D., Herreros, J. M., Hervier, V., Heske, A., Heurtel, A., Hildebrandt, S. R., Hills, R., Hivon, E., Hobson, M., Hollert, D., Holmes, W., Hornstrup, Allan, Hovest, W., Hoyland, R. J., Huey, G., Huffenberger, K. M., Hughes, N., Israelsson, U., Jackson, B., Jaffe, A., Jaffe, T. R., Jagemann, T., Jessen, Niels Christian, Jewell, J., Jones, W., Juvela, M., Kaplan, J., Karlmann, P., Keck, F., Kelhänen, E., King, M., Kisner, T. S., Kletzkine, P., Kneissi, R., Knoche, J., Knox, L., Koch, T., Krassenburg, M., Kurki-Suonio, H., Lähteenmäki, A., Lagache, G., Lagorio, E., Lami, P., Lande, J., Lange, A., Langlet, F., Lapini, R., Lapolla, M., Lasenby, A., Le Jeune, M., Leahy, J. P., Lefebvre, M., Legrand, F., Le Meur, G., Leonardi, R., Leriche, B., Leroy, C., Leutenegger, P., Levin, S. M., Lilje, P. B., Lindensmith, C., Linden-Vørnle, Michael, Loc, A., Longval, Y., Lubin, P. M., Luchik, T., Luthold, I., Macias-Perez, J. F., Maciaszek, T., MacTavish, C., Madden, S., Maffei, B., Magneville, C., Maino, D., Mambretti, A., Mansoux, B., Marchioro, D., Maris, M., Marliani, F., Marrucho, J.-C., Marti-Canales, J., Martinez-Gonzalez, E., Martin-Polegre, A., Martin, P., Marty, C., Masi, S., Massardi, M., Matarrese, S., Matthai, F., Mazzotta, P., McDonald, A., McGrath, P., Mediavilla, A., Meinhold, P. R., Mélin, J.-B., Melot, F., Mendes, L., Mennella, A., Mervier, C., Meslier, L., Miccolis, M., Miville-Deschenes, M.-A., Moneti, A., Montet, D., Montier, L., Mora, J., Morgante, G., Morigi, G., Morinaud, G., Morisset, N., Mortlock, D., Mottet, S., Mulder, J., Munshi, D., Murphy, A., Murphy, P., Musi, P., Narbonne, J., Naselsky, P., Nash, A., Nati, F., Natoli, P., Netterfield, B., Newell, J., Nexon, M., Nicolas, C., Hansen, P. H., Ninane, N., Noviello, F., Novikov, D., Novikov, I., O´Dwyer, I. J., Oldeman, P., Olivier, P., Ouchet, L., Oxborrow, Carol Anne, Pérez-Cuevas, L., Pagan, L., Paine, C., Pajot, F., Paladini, R., Pancher, F., Panh, J., Parks, G., Parnaudeau, P., Patridge, B., Parvin, B., Pascual, J. P., Pasian, F., Pearson, D. P., Pearson, T., Pecora, M., Perdereau, O., Perotto, L., Perrotta, F., Placentini, F., Piat, M., Pierpaoli, E., Piersanti, O., Plaige, E., Plaszczynski, S., Platania, P., Pointecouteau, E., Polenta, G., Ponthieu, N., Popa, L., Poulleau, G., Poutanen, T., Prézeau, G., Pradell, L., Prina, M., Prunet, S., Rachen, J. P., Rambaud, D., Rame, F., Rasmussen, I., Rautakoski, J., Reach, W. T., Rebolo, R., Reinecke, M., Reiter, J., Renault, C., Ricciardi, S., Rideau, P., Riller, T., Ristorcelli, I., Riti, J. B., Tauber, J. A., Mandoles, N., Puget, J.-L., Banos, T., Bersanelli, M., Bouchet, F. R., Butler, R. C., Charra, J., Crone, G., Dodsworth, J., Efstathiou, G., Gispert, R., Guyot, G., Gregorio, A., Juillet, J. J., Lamarre, J.-M., Laureijs, R. J., Lawrence, C. R., Nørgaard-Nielsen, Hans Ulrik, Passvogel, T., Reix, J. M., Texier, D., Vilbert, L., Zacchei, A., Ade, P. A. R., Aghanim, N., Aja, B., Alippi, E., Aloy, L., Armand, P., Arnaud, M., Arondel, A., Arreola-Villanueva, A., Artal, E., Artina, E., Arts, A., Ashdown, M., Aumont, J., Azzaro, M., Bacchetta, A., Baccigalupi, C., Baker, M., Balasini, M., Balbi, A., Banday, A. J., Barbier, G., Barreiro, R. B., Bartelmann, M., Battaglia, P., Battaner, E., Benabed, K., Beney, J.-L., Beneyton, R., Bennett, K., Benoit, A., Bernard, J.-P., Bhandari, P., Bhatia, R., Biggi, M., Biggins, R., Billig, G., Blanc, Y., Blavot, H., Bock, J. J., Bonaldi, A., Bond, R., Bonis, J., Borders, J., Borrill, J., Boschini, L., Boulanger, F., Bouvier, J., Bouzit, M., Bowman, R., Bréelle, E., Bradshaw, T., Braghin, M., Bremer, M., Brienza, D., Broszkiewicz, D., Burigana, C., Burkhalter, M., Cabella, P., Cafferty, T., Cairola, M., Caminade, S., Camus, P., Cantalupo, C. M., Cappellini, B., Cardoso, J.-F., Carr, R., Catalono, A., Caýon, L., Cesa, M., Chaigneau, M., Challinor, A., Chamballu, A., Chambelland, J. P., Charra, M., Chiang, L.-Y., Chlewicki, G., Christensen, P. R., Church, S., Ciancietta, E., Cibrario, M., Cizeron, R., Clements, D., Collaudin, B., Colley, J.-M., Colombi, S., Colombo, A., Colombo, F., Corre, O., Couchot, F., Cougrand, B., Coulais, A., Couzin, P., Crane, B., Crill, B., Crook, M., Crumb, D., cuttala, F., Döri, U., da Silva, P., Daddato, R., Damasio, C., Danese, L., d'Aquino, G., D'Arcangelo, O., Dassas, K., Davies, R. D., Davies, W., Davis, R. J., De Bernardis, P., de Chambure, D., de Gasperis, G., De la Fuente, M. L., De Paco, P., De Rosa, A., De Troia, G., De Zotti, G., Dehamme, M., Delabrouille, J., Delouis, J.-M., Désert, F.-X., di Girolamo, G., Dickinson, C., Doelling, E., Dolag, K., Domken, I., Douspis, M., Doyle, D., Du, S., Dubruel, D., Dufour, C., Dumesnil, C., Dupac, X., Duret, P., Eder, C., Elfving, A., Enßlin, T. A., Eng, P., English, K., Eriksen, H. K., Estaria, P., Falvella, M. C., Ferrari, F., Finelli, F., Fishman, A., Fogliani, S., Foley, S., Fonseca, A., Forma, G., Forni, O., Fosalba, P., Fourmond, J.-J., Frallis, M., Franceschet, C., Franceschi, E., François, S., Frerking, M., Gómez-Reñasco, M. F., Gorski, K. M., Gaier, T. C., Galeotta, S., Ganga, K., García Lázaro, J., Garnica, A., Gaspard, M., Gavila, E., Giard, m., Giardino, G., Glenger, G., Giraud-Heraud, Y., Glorian, J.-M., Griffin, M., Gruppuso, A., Guglieimi, L., Guichon, D., Guillaume, B., Guillouet, P., Haissinski, J., Hansen, F. K., Hardy, J., Harrison, D., Hazell, A., Hechler, M., Heckenauer, V., Heinzer, D., Hell, R., Henrot-Versillé, S., Hernándes-Monteagudo, C., Herranz, D., Herreros, J. M., Hervier, V., Heske, A., Heurtel, A., Hildebrandt, S. R., Hills, R., Hivon, E., Hobson, M., Hollert, D., Holmes, W., Hornstrup, Allan, Hovest, W., Hoyland, R. J., Huey, G., Huffenberger, K. M., Hughes, N., Israelsson, U., Jackson, B., Jaffe, A., Jaffe, T. R., Jagemann, T., Jessen, Niels Christian, Jewell, J., Jones, W., Juvela, M., Kaplan, J., Karlmann, P., Keck, F., Kelhänen, E., King, M., Kisner, T. S., Kletzkine, P., Kneissi, R., Knoche, J., Knox, L., Koch, T., Krassenburg, M., Kurki-Suonio, H., Lähteenmäki, A., Lagache, G., Lagorio, E., Lami, P., Lande, J., Lange, A., Langlet, F., Lapini, R., Lapolla, M., Lasenby, A., Le Jeune, M., Leahy, J. P., Lefebvre, M., Legrand, F., Le Meur, G., Leonardi, R., Leriche, B., Leroy, C., Leutenegger, P., Levin, S. M., Lilje, P. B., Lindensmith, C., Linden-Vørnle, Michael, Loc, A., Longval, Y., Lubin, P. M., Luchik, T., Luthold, I., Macias-Perez, J. F., Maciaszek, T., MacTavish, C., Madden, S., Maffei, B., Magneville, C., Maino, D., Mambretti, A., Mansoux, B., Marchioro, D., Maris, M., Marliani, F., Marrucho, J.-C., Marti-Canales, J., Martinez-Gonzalez, E., Martin-Polegre, A., Martin, P., Marty, C., Masi, S., Massardi, M., Matarrese, S., Matthai, F., Mazzotta, P., McDonald, A., McGrath, P., Mediavilla, A., Meinhold, P. R., Mélin, J.-B., Melot, F., Mendes, L., Mennella, A., Mervier, C., Meslier, L., Miccolis, M., Miville-Deschenes, M.-A., Moneti, A., Montet, D., Montier, L., Mora, J., Morgante, G., Morigi, G., Morinaud, G., Morisset, N., Mortlock, D., Mottet, S., Mulder, J., Munshi, D., Murphy, A., Murphy, P., Musi, P., Narbonne, J., Naselsky, P., Nash, A., Nati, F., Natoli, P., Netterfield, B., Newell, J., Nexon, M., Nicolas, C., Hansen, P. H., Ninane, N., Noviello, F., Novikov, D., Novikov, I., O´Dwyer, I. J., Oldeman, P., Olivier, P., Ouchet, L., Oxborrow, Carol Anne, Pérez-Cuevas, L., Pagan, L., Paine, C., Pajot, F., Paladini, R., Pancher, F., Panh, J., Parks, G., Parnaudeau, P., Patridge, B., Parvin, B., Pascual, J. P., Pasian, F., Pearson, D. P., Pearson, T., Pecora, M., Perdereau, O., Perotto, L., Perrotta, F., Placentini, F., Piat, M., Pierpaoli, E., Piersanti, O., Plaige, E., Plaszczynski, S., Platania, P., Pointecouteau, E., Polenta, G., Ponthieu, N., Popa, L., Poulleau, G., Poutanen, T., Prézeau, G., Pradell, L., Prina, M., Prunet, S., Rachen, J. P., Rambaud, D., Rame, F., Rasmussen, I., Rautakoski, J., Reach, W. T., Rebolo, R., Reinecke, M., Reiter, J., Renault, C., Ricciardi, S., Rideau, P., Riller, T., Ristorcelli, I., and Riti, J. B.

Abstract

The European Space Agency's Planck satellite, launched on 14 May 2009, is the third-generation space experiment in the field of cosmic microwave background (CMB) research. It will image the anisotropies of the CMB over the whole sky, with unprecedented sensitivity ( ~ 2 × 10-6) and angular resolution (~5 arcmin). Planck will provide a major source of information relevant to many fundamental cosmological problems and will test current theories of the early evolution of the Universe and the origin of structure. It will also address a wide range of areas of astrophysical research related to the Milky Way as well as external galaxies and clusters of galaxies. The ability of Planck to measure polarization across a wide frequency range (30-350 GHz), with high precision and accuracy, and over the whole sky, will provide unique insight, not only into specific cosmological questions, but also into the properties of the interstellar medium. This paper is part of a series which describes the technical capabilities of the Planck scientific payload. It is based on the knowledge gathered during the on-ground calibration campaigns of the major subsystems, principally its telescope and its two scientific instruments, and of tests at fully integrated satellite level. It represents the best estimate before launch of the technical performance that the satellite and its payload will achieve in flight. In this paper, we summarise the main elements of the payload performance, which is described in detail in the accompanying papers. In addition, we describe the satellite performance elements which are most relevant for science, and provide an overview of the plans for scientific operations and data analysis.

Published
2010

15. Planckpre-launch status: ThePlanckmission

Author

Tauber, J. A., primary, Mandolesi, N., additional, Puget, J.-L., additional, Banos, T., additional, Bersanelli, M., additional, Bouchet, F. R., additional, Butler, R. C., additional, Charra, J., additional, Crone, G., additional, Dodsworth, J., additional, Efstathiou, G., additional, Gispert, R., additional, Guyot, G., additional, Gregorio, A., additional, Juillet, J. J., additional, Lamarre, J.-M., additional, Laureijs, R. J., additional, Lawrence, C. R., additional, Nørgaard-Nielsen, H. U., additional, Passvogel, T., additional, Reix, J. M., additional, Texier, D., additional, Vibert, L., additional, Zacchei, A., additional, Ade, P. A. R., additional, Aghanim, N., additional, Aja, B., additional, Alippi, E., additional, Aloy, L., additional, Armand, P., additional, Arnaud, M., additional, Arondel, A., additional, Arreola-Villanueva, A., additional, Artal, E., additional, Artina, E., additional, Arts, A., additional, Ashdown, M., additional, Aumont, J., additional, Azzaro, M., additional, Bacchetta, A., additional, Baccigalupi, C., additional, Baker, M., additional, Balasini, M., additional, Balbi, A., additional, Banday, A. J., additional, Barbier, G., additional, Barreiro, R. B., additional, Bartelmann, M., additional, Battaglia, P., additional, Battaner, E., additional, Benabed, K., additional, Beney, J.-L., additional, Beneyton, R., additional, Bennett, K., additional, Benoit, A., additional, Bernard, J.-P., additional, Bhandari, P., additional, Bhatia, R., additional, Biggi, M., additional, Biggins, R., additional, Billig, G., additional, Blanc, Y., additional, Blavot, H., additional, Bock, J. J., additional, Bonaldi, A., additional, Bond, R., additional, Bonis, J., additional, Borders, J., additional, Borrill, J., additional, Boschini, L., additional, Boulanger, F., additional, Bouvier, J., additional, Bouzit, M., additional, Bowman, R., additional, Bréelle, E., additional, Bradshaw, T., additional, Braghin, M., additional, Bremer, M., additional, Brienza, D., additional, Broszkiewicz, D., additional, Burigana, C., additional, Burkhalter, M., additional, Cabella, P., additional, Cafferty, T., additional, Cairola, M., additional, Caminade, S., additional, Camus, P., additional, Cantalupo, C. M., additional, Cappellini, B., additional, Cardoso, J.-F., additional, Carr, R., additional, Catalano, A., additional, Cayón, L., additional, Cesa, M., additional, Chaigneau, M., additional, Challinor, A., additional, Chamballu, A., additional, Chambelland, J. P., additional, Charra, M., additional, Chiang, L.-Y., additional, Chlewicki, G., additional, Christensen, P. R., additional, Church, S., additional, Ciancietta, E., additional, Cibrario, M., additional, Cizeron, R., additional, Clements, D., additional, Collaudin, B., additional, Colley, J.-M., additional, Colombi, S., additional, Colombo, A., additional, Colombo, F., additional, Corre, O., additional, Couchot, F., additional, Cougrand, B., additional, Coulais, A., additional, Couzin, P., additional, Crane, B., additional, Crill, B., additional, Crook, M., additional, Crumb, D., additional, Cuttaia, F., additional, Dörl, U., additional, da Silva, P., additional, Daddato, R., additional, Damasio, C., additional, Danese, L., additional, d'Aquino, G., additional, D'Arcangelo, O., additional, Dassas, K., additional, Davies, R. D., additional, Davies, W., additional, Davis, R. J., additional, De Bernardis, P., additional, de Chambure, D., additional, de Gasperis, G., additional, De la Fuente, M. 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C., additional, Ferrari, F., additional, Finelli, F., additional, Fishman, A., additional, Fogliani, S., additional, Foley, S., additional, Fonseca, A., additional, Forma, G., additional, Forni, O., additional, Fosalba, P., additional, Fourmond, J.-J., additional, Frailis, M., additional, Franceschet, C., additional, Franceschi, E., additional, François, S., additional, Frerking, M., additional, Gómez-Reñasco, M. F., additional, Górski, K. M., additional, Gaier, T. C., additional, Galeotta, S., additional, Ganga, K., additional, García Lázaro, J., additional, Garnica, A., additional, Gaspard, M., additional, Gavila, E., additional, Giard, M., additional, Giardino, G., additional, Gienger, G., additional, Giraud-Heraud, Y., additional, Glorian, J.-M., additional, Griffin, M., additional, Gruppuso, A., additional, Guglielmi, L., additional, Guichon, D., additional, Guillaume, B., additional, Guillouet, P., additional, Haissinski, J., additional, Hansen, F. K., additional, Hardy, J., additional, Harrison, D., additional, Hazell, A., additional, Hechler, M., additional, Heckenauer, V., additional, Heinzer, D., additional, Hell, R., additional, Henrot-Versillé, S., additional, Hernández-Monteagudo, C., additional, Herranz, D., additional, Herreros, J. M., additional, Hervier, V., additional, Heske, A., additional, Heurtel, A., additional, Hildebrandt, S. R., additional, Hills, R., additional, Hivon, E., additional, Hobson, M., additional, Hollert, D., additional, Holmes, W., additional, Hornstrup, A., additional, Hovest, W., additional, Hoyland, R. J., additional, Huey, G., additional, Huffenberger, K. M., additional, Hughes, N., additional, Israelsson, U., additional, Jackson, B., additional, Jaffe, A., additional, Jaffe, T. R., additional, Jagemann, T., additional, Jessen, N. C., additional, Jewell, J., additional, Jones, W., additional, Juvela, M., additional, Kaplan, J., additional, Karlman, P., additional, Keck, F., additional, Keihänen, E., additional, King, M., additional, Kisner, T. S., additional, Kletzkine, P., additional, Kneissl, R., additional, Knoche, J., additional, Knox, L., additional, Koch, T., additional, Krassenburg, M., additional, Kurki-Suonio, H., additional, Lähteenmäki, A., additional, Lagache, G., additional, Lagorio, E., additional, Lami, P., additional, Lande, J., additional, Lange, A., additional, Langlet, F., additional, Lapini, R., additional, Lapolla, M., additional, Lasenby, A., additional, Le Jeune, M., additional, Leahy, J. P., additional, Lefebvre, M., additional, Legrand, F., additional, Le Meur, G., additional, Leonardi, R., additional, Leriche, B., additional, Leroy, C., additional, Leutenegger, P., additional, Levin, S. M., additional, Lilje, P. B., additional, Lindensmith, C., additional, Linden-Vørnle, M., additional, Loc, A., additional, Longval, Y., additional, Lubin, P. M., additional, Luchik, T., additional, Luthold, I., additional, Macias-Perez, J. F., additional, Maciaszek, T., additional, MacTavish, C., additional, Madden, S., additional, Maffei, B., additional, Magneville, C., additional, Maino, D., additional, Mambretti, A., additional, Mansoux, B., additional, Marchioro, D., additional, Maris, M., additional, Marliani, F., additional, Marrucho, J.-C., additional, Martí-Canales, J., additional, Martínez-González, E., additional, Martín-Polegre, A., additional, Martin, P., additional, Marty, C., additional, Marty, W., additional, Masi, S., additional, Massardi, M., additional, Matarrese, S., additional, Matthai, F., additional, Mazzotta, P., additional, McDonald, A., additional, McGrath, P., additional, Mediavilla, A., additional, Meinhold, P. R., additional, Mélin, J.-B., additional, Melot, F., additional, Mendes, L., additional, Mennella, A., additional, Mervier, C., additional, Meslier, L., additional, Miccolis, M., additional, Miville-Deschenes, M.-A., additional, Moneti, A., additional, Montet, D., additional, Montier, L., additional, Mora, J., additional, Morgante, G., additional, Morigi, G., additional, Morinaud, G., additional, Morisset, N., additional, Mortlock, D., additional, Mottet, S., additional, Mulder, J., additional, Munshi, D., additional, Murphy, A., additional, Murphy, P., additional, Musi, P., additional, Narbonne, J., additional, Naselsky, P., additional, Nash, A., additional, Nati, F., additional, Natoli, P., additional, Netterfield, B., additional, Newell, J., additional, Nexon, M., additional, Nicolas, C., additional, Nielsen, P. H., additional, Ninane, N., additional, Noviello, F., additional, Novikov, D., additional, Novikov, I., additional, O'Dwyer, I. J., additional, Oldeman, P., additional, Olivier, P., additional, Ouchet, L., additional, Oxborrow, C. A., additional, Pérez-Cuevas, L., additional, Pagan, L., additional, Paine, C., additional, Pajot, F., additional, Paladini, R., additional, Pancher, F., additional, Panh, J., additional, Parks, G., additional, Parnaudeau, P., additional, Partridge, B., additional, Parvin, B., additional, Pascual, J. P., additional, Pasian, F., additional, Pearson, D. P., additional, Pearson, T., additional, Pecora, M., additional, Perdereau, O., additional, Perotto, L., additional, Perrotta, F., additional, Piacentini, F., additional, Piat, M., additional, Pierpaoli, E., additional, Piersanti, O., additional, Plaige, E., additional, Plaszczynski, S., additional, Platania, P., additional, Pointecouteau, E., additional, Polenta, G., additional, Ponthieu, N., additional, Popa, L., additional, Poulleau, G., additional, Poutanen, T., additional, Prézeau, G., additional, Pradell, L., additional, Prina, M., additional, Prunet, S., additional, Rachen, J. P., additional, Rambaud, D., additional, Rame, F., additional, Rasmussen, I., additional, Rautakoski, J., additional, Reach, W. T., additional, Rebolo, R., additional, Reinecke, M., additional, Reiter, J., additional, Renault, C., additional, Ricciardi, S., additional, Rideau, P., additional, Riller, T., additional, Ristorcelli, I., additional, Riti, J. B., additional, Rocha, G., additional, Roche, Y., additional, Pons, R., additional, Rohlfs, R., additional, Romero, D., additional, Roose, S., additional, Rosset, C., additional, Rouberol, S., additional, Rowan-Robinson, M., additional, Rubiño-Martín, J. A., additional, Rusconi, P., additional, Rusholme, B., additional, Salama, M., additional, Salerno, E., additional, Sandri, M., additional, Santos, D., additional, Sanz, J. L., additional, Sauter, L., additional, Sauvage, F., additional, Savini, G., additional, Schmelzel, M., additional, Schnorhk, A., additional, Schwarz, W., additional, Scott, D., additional, Seiffert, M. D., additional, Shellard, P., additional, Shih, C., additional, Sias, M., additional, Silk, J. I., additional, Silvestri, R., additional, Sippel, R., additional, Smoot, G. F., additional, Starck, J.-L., additional, Stassi, P., additional, Sternberg, J., additional, Stivoli, F., additional, Stolyarov, V., additional, Stompor, R., additional, Stringhetti, L., additional, Strommen, D., additional, Stute, T., additional, Sudiwala, R., additional, Sugimura, R., additional, Sunyaev, R., additional, Sygnet, J.-F., additional, Türler, M., additional, Taddei, E., additional, Tallon, J., additional, Tamiatto, C., additional, Taurigna, M., additional, Taylor, D., additional, Terenzi, L., additional, Thuerey, S., additional, Tillis, J., additional, Tofani, G., additional, Toffolatti, L., additional, Tommasi, E., additional, Tomasi, M., additional, Tonazzini, E., additional, Torre, J.-P., additional, Tosti, S., additional, Touze, F., additional, Tristram, M., additional, Tuovinen, J., additional, Tuttlebee, M., additional, Umana, G., additional, Valenziano, L., additional, Vallée, D., additional, van der Vlis, M., additional, Van Leeuwen, F., additional, Vanel, J.-C., additional, Van-Tent, B., additional, Varis, J., additional, Vassallo, E., additional, Vescovi, C., additional, Vezzu, F., additional, Vibert, D., additional, Vielva, P., additional, Vierra, J., additional, Villa, F., additional, Vittorio, N., additional, Vuerli, C., additional, Wade, L. A., additional, Walker, A. R., additional, Wandelt, B. D., additional, Watson, C., additional, Werner, D., additional, White, M., additional, White, S. D. M., additional, Wilkinson, A., additional, Wilson, P., additional, Woodcraft, A., additional, Yoffo, B., additional, Yun, M., additional, Yurchenko, V., additional, Yvon, D., additional, Zhang, B., additional, Zimmermann, O., additional, Zonca, A., additional, and Zorita, D., additional

Published
2010
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16. Design and tests of high sensitivity NTD Ge thermometers for the Planck-High Frequency Instrument

Author

Porter, F. Scott, Piat, M., Torre, J. P., Lamarre, J. M., Beeman, J. W., Bhatia, R. S., Leriche, B., Crussaire, J. P., Langlet, F., Porter, F. Scott, Piat, M., Torre, J. P., Lamarre, J. M., Beeman, J. W., Bhatia, R. S., Leriche, B., Crussaire, J. P., and Langlet, F.

Abstract

The High Frequency Instrument of Planck needs high sensitivity semi-conductors at low temperature to monitor the temperature of the bolometer plate. We have modeled such thermometers by using a semi-analytical approach of Anderson insulators, taking into account both the electrical field and the electron/phonon decoupling effects. The optimized design uses convenient NTD Ge material and has larger dimension than the initial design. The first measurements of these optimized thermometers showed a significant thermal de-coupling effect due to Kapitza resistance with its mechanical support. Nevertheless, a sensitivity of about 8 nK.Hz^(–0.5), not far from the predicted one, was obtained. The noise spectrum of the thermometer was flat down to 1 Hz, dominated at lower frequency by the thermal fluctuations.

Published
2002

17. Different effects of epoprostenol on ischemia-induced ventricular arrhythmias in dogs

Author

Puddu, P. E., Langlet, F., Lanti, M., Guillen, J. C., Dawodu, A. A., Monti, F., Michele Salvatore Maria SCHIARITI, and Reale, A.

Subjects
Male, complications, cardiac, animals, arrhythmias, coronary disease, dogs, drug effects, drug therapy/etiology/physiopathology, electrocardiography, epoprostenol, female, heart ventricles, hemodynamics, male, therapeutic use, Heart Ventricles, Hemodynamics, Arrhythmias, Cardiac, Coronary Disease, Epoprostenol, Electrocardiography, Dogs, Animals, Female
Abstract

In 60 randomized dogs the effects of epoprostenol infusion (100 ng/kg/min) on ischemia-induced premature ventricular contractions (PVCs), ventricular tachycardia (VT), ventricular flutters and ventricular fibrillation were studied. The circumflex coronary artery occlusion canine model of sudden death was used. The results demonstrate different effects of epoprostenol on ischemia-induced ventricular arrhythmias: 1) both postischemic (7 of 30 vs 15 of 30, p = 0.0298) and postreperfusion (5 of 23 vs 8 of 15, p = 0.0492) ventricular fibrillations were prevented in epoprostenol dogs with an improvement of the global survival rate (18 of 30 vs 7 of 30, p = 0.0019) as compared to controls; 2) in epoprostenol treated dogs a significantly increased incidence of non lethal arrhythmias-including ventricular flutters that occurred in 12 of 30 dogs vs 4 of 30 in controls (p = 0.0195)--was observed; 3) a positive correlation between the percent diastolic pressure fall 10 min after the start of epoprostenol infusion and the number of non lethal arrhythmias was noted. However, hemodynamic effects of the compound, suggesting an oxygen sparing action, did not preclude the antifibrillatory effectiveness. Thus, the antifibrillatory and antiarrhythmic effects of epoprostenol after circumflex coronary artery occlusion and reperfusion in dogs seem independent from one another.

Published
1990

19. Design and tests of high sensitivity NTD Ge thermometers for the Planck-High Frequency Instrument.

Author

Piat, M., Torre, J. P., Lamarre, J. M., Beeman, J. W., Bhatia, R. S., Leriche, B., Crussaire, J. P., and Langlet, F.

Subjects
THERMOMETERS, SEMICONDUCTORS, MATERIALS at low temperatures
Abstract

The High Frequency Instrument of Planck needs high sensitivity semi-conductors at low temperature to monitor the temperature of the bolometer plate. We have modeled such thermometers by using a semi-analytical approach of Anderson insulators, taking into account both the electrical field and the electron/phonon decoupling effects. The optimized design uses convenient NTD Ge material and has larger dimension than the initial design. The first measurements of these optimized thermometers showed a significant thermal de-coupling effect due to Kapitza resistance with its mechanical support. Nevertheless, a sensitivity of about 8nK.Hz[sup -0.5], not far from the predicted one, was obtained. The noise spectrum of the thermometer was flat down to 1Hz, dominated at lower frequency by the thermal fluctuations. [ABSTRACT FROM AUTHOR]

Published
2002

24. Epoprostenol (PGI2) prevents postischemic ventricular fibrillation and improves outcome in a canine model of sudden death

Author

Jouve, R., Puddu, Paolo Emilio, Langlet, F., Guillen, J. C., Gautier, T., Cano, J. P., and Serradimigni, A.

Subjects
Male, Time Factors, Platelet Aggregation, Animal, Hemodynamics, Sudden, Epoprostenol, Animals, Death, Sudden, Disease Models, Animal, Dogs, Electrocardiography, Epoprostenol, pharmacology, Female, Hemodynamics, drug effects, Male, Platelet Aggregation, drug effects, Time Factors, Ventricular Fibrillation, prevention /&/ control, Death, Death, Sudden, Disease Models, Animal, Electrocardiography, Dogs, drug effects, Disease Models, Ventricular Fibrillation, Animals, Female, pharmacology
Abstract

In a left circumflex coronary artery occlusion-reperfusion canine model of sudden death the hemodynamic, antiplatelet, antiischemic and antifibrillatory activities of 100 ng.kg-1.min-1 infusion of epoprostenol (Prostacyclin, Flolan, Wellcome Foundation, London, UK) were investigated at random in 40 animals. Significant changes were observed on epoprostenol infusion for mean arterial blood pressure (80 +/- 4 vs 93 +/- 7 mmHg, p less than 0.01), systemic vascular resistance (2379 +/- 769 vs 3290 +/- 768 dynes.s.cm-5, p less than 0.01) and rate-pressure product (10800 +/- 1200 vs 13450 +/- 2500 mmHg.beat.min-1, p less than 0.01) while heart rate did not change. In addition platelet aggregation intensity to ADP decreased by 50% (p less than 0.001). On occlusion treated animals presented with lower systemic vascular resistance (3132 +/- 895 vs 4931 +/- 1079 dynes.s.cm-5, p less than 0.05), rate-pressure product (9950 +/- 850 vs 12168 +/- 1980 mmHg.beat.min-1, p less than 0.01) and mean heart rate (145 +/- 10 vs 169 +/- 10 beats.min-1, p less than 0.01) while the anti-platelet activity persisted. A lower D2-3 mean ST segment elevation occurred at 3 min postocclusion in epoprostenol treated dogs (7.7 +/- 5 vs 14 +/- 8.7 mm, p less than 0.02). The incidence of postischemic ventricular fibrillation was significantly reduced (5/20 i.e. 25% vs 12/20 i.e. 60%, p less than 0.05) in the epoprostenol treated dogs. At the end of the occlusion-reperfusion period treated animals showed an improvement of outcome (10/20 i.e. 50% vs 2/20 i.e. 10%, p less than 0.01). It is suggested that the hemodynamic effect of the drug may provide guidelines for the clinical management of patients with acute myocardial ischemia, when a concomitant antiarrhythmic effect is looked for.

Published
1985

27. Effects of cicletanine in the left circumflex coronary artery occlusion-reperfusion canine model of sudden death: analysis of 107 experiments using Cox's proportional hazards model

Author

Jouve, R., Paolo Emilio Puddu, Langlet, F., Lanti, M., Guillen, J. C., Rolland, P. H., and Serradimigni, A.

Subjects
Male, etiology/prevention /&/ control, Pyridines, etiology, Heart Ventricles, Statistics as Topic, 6-Ketoprostaglandin F1 alpha, blood, Animals, Antihypertensive Agents, therapeutic use, Arrhythmias, Cardiac, etiology/prevention /&/ control, Blood Pressure, Coronary Disease, drug therapy/physiopathology, Death, Sudden, etiology, Diuretics, therapeutic use, Dogs, Electrocardiography, Female, Heart Rate, Heart Ventricles, Male, Perfusion, Pyridines, Statistics as Topic, Blood Pressure, Coronary Disease, Arrhythmias, Death, Sudden, Electrocardiography, Dogs, blood, Heart Rate, Animals, Diuretics, Antihypertensive Agents, Arrhythmias, Cardiac, drug therapy/physiopathology, Death, Perfusion, therapeutic use, Female
Abstract

Multivariate analysis of survival using Cox's proportional hazards model demonstrates that several clinically measurable covariates are determinants of life-threatening arrhythmias following left circumflex coronary artery occlusion-reperfusion in 107 dogs. These are heart rate, ST segment elevation and mean aortic pressure immediately (3 min) following occlusion, and the presence of early (0-10 min) post-occlusion sustained ventricular tachycardia. The risk of occlusion-reperfusion ventricular fibrillation was determined according to Cox's solution based on ST segment elevation, thus enabling quantification of the role of cicletanine. Since cicletanine-treated dogs had reduced mean ST segment elevation at 3 min post-occlusion, lower incidence of early post-occlusion (0-10 min) sustained ventricular tachycardia, and increased endogenous production of prostacyclin, and the latter was inversely correlated with the level of ST segment elevation, it is concluded that such favourable effects on the ischaemic myocardium were contributory to the improved outcome in these experiments. These effects on the ischaemic myocardium obtained in spite of a hypotensive action in the experimental setting might be regarded as desirable and it is therefore suggested that they should be further investigated by pharmacodynamic studies in human subjects.

50. Antichlamydial antibodies in pelvic inflammatory disease.

Author

Simmons, P D, Forsey, T, Thin, R N, Treharne, J D, Darougar, S, Langlet, F, and Pandhi, R K

Abstract

The role of Chlamydia trachomatis in pelvic inflammatory disease (PID) diagnosed without laparoscopy was assessed by measuring antichlamydial antibodies in the patient's serum and by comparing the results with those in patients with uncomplicated non-specific genital infection (NSGI) and gonorrhoea and in non-infected controls. A modified microimmunofluorescence test was used. Patients with severe PID had significantly more positive antichlamydial IgG and IgM results than did control subjects, patients with gonorrhoea, and patients with NSGI. Less severe PID was associated with significantly raised levels of antichlamydial IgG antibodies compared with NSGI and controls and with raised levels of IgM antibodies compared with controls. Two patients with PID had lower genital tract gonorrhoea, one of whom had raised antichlamydial antibody levels. These findings may indicate a mixed infection and therapy should be reviewed in such patients. A serological diagnosis of chlamydial infection is relatively easy and cheap and enables a rapid diagnosis of chlamydial infection to be made. [ABSTRACT FROM PUBLISHER]

Published
1979
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