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2. Presence of specific SARS-COV2 antibodies in hemodialysis patients and their caregivers after the first wave of COVID-19

Author

Robert, Thomas, Lano, Guillaume, Resseguier, Noémie, Bobot, Mickaël, Bouchouareb, Dammar, Burtey, Stéphane, de Lamballerie, Xavier, Dhorne, Jean, Dussol, Bertrand, Duval, Ariane, Faraut, Julien, Fourié, Toscane, Giaime, Philippe, Hallah, Mourad, Jaubert, Dominique, Jéhel, Océane, Legris, Tristan, Liotatis, Stéphane, Moal, Valérie, Ninove, Laetitia, Pedinielli, Nathalie, Pelletier, Marion, Romeu-Giannoli, Manon, Saba, Mariela, Sallée, Marion, Samson, Laurent, Saveanu, Adriana, Scarfoglière, Violaine, Sebahoun, Pascale, Vial, Romain, Von Kotze, Clarissa, Brunet, Philippe, Lebrun, Gaëtan, Bataille, Stanislas, and Jourde-Chiche, Noémie

Published
2022
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6. Pseudo-hyperkalaemia in ambulatory samples: the never-ending story?

Author

Lano, Guillaume, Lefevre, Flora, Buffat, Christophe, Schlegel, Laurent, Dho, Emmanuel, Jantzen, Rodolphe, Resseguier, Noémie, Robert, Thomas, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], and Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION)

Subjects
Transplantation, Nephrology, Humans, Hyperkalemia, Ambulatory Care Facilities, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2021
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10. Spike and neutralizing antibodies response to COVID-19 vaccination in haemodialysis patients

Author

Giot, Matthieu, primary, Fourié, Toscane, additional, Lano, Guillaume, additional, Villarroel, Paola Mariela Saba, additional, Lamballeri, Xavier de, additional, Gully, Marion, additional, Samson, Laurent, additional, Farault, Julien, additional, Bouchouareb, Dammar, additional, Jehel, Océane, additional, Brunet, Philippe, additional, Jourde-Chiche, Noémie, additional, Ninove, Laetitia, additional, and Robert, Thomas, additional

Published
2021
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12. Triage of Patients Suspected of COVID-19 in Chronic Hemodialysis: Eosinophil Count Differentiates Low and High Suspicion of COVID-19

Author

Vial, Romain, primary, Gully, Marion, additional, Bobot, Mickael, additional, Scarfoglière, Violaine, additional, Brunet, Philippe, additional, Bouchouareb, Dammar, additional, Duval, Ariane, additional, Zino, He-oh, additional, Faraut, Julien, additional, Jehel, Océane, additional, Berdad-Haddad, Yaël, additional, Burtey, Stéphane, additional, Jarrot, Pierre-André, additional, Lano, Guillaume, additional, and Robert, Thomas, additional

Published
2020
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13. Risk factors for severity of COVID-19 in chronic dialysis patients from a multicentre French cohort

Author

Lano, Guillaume, primary, Braconnier, Antoine, additional, Bataille, Stanislas, additional, Cavaille, Guilhem, additional, Moussi-Frances, Julie, additional, Gondouin, Bertrand, additional, Bindi, Pascal, additional, Nakhla, Magued, additional, Mansour, Janette, additional, Halin, Pascale, additional, Levy, Bénédicte, additional, Canivet, Eric, additional, Gaha, Khaled, additional, Kazes, Isabelle, additional, Noel, Natacha, additional, Wynckel, Alain, additional, Debrumetz, Alexandre, additional, Jourde-Chiche, Noemie, additional, Moal, Valerie, additional, Vial, Romain, additional, Scarfoglière, Violaine, additional, Bobot, Mickael, additional, Gully, Marion, additional, Legris, Tristan, additional, Pelletier, Marion, additional, Sallee, Marion, additional, Burtey, Stephane, additional, Brunet, Philippe, additional, Robert, Thomas, additional, and Rieu, Philippe, additional

Published
2020
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14. Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Author

Guervilly, Christophe, primary, Burtey, Stephane, additional, Sabatier, Florence, additional, Cauchois, Raphaël, additional, Lano, Guillaume, additional, Abdili, Evelyne, additional, Daviet, Florence, additional, Arnaud, Laurent, additional, Brunet, Philippe, additional, Hraiech, Sami, additional, Jourde-Chiche, Noémie, additional, Koubi, Marie, additional, Lacroix, Romaric, additional, Pietri, Léa, additional, Berda, Yaël, additional, Robert, Thomas, additional, Degioanni, Clara, additional, Velier, Mélanie, additional, Papazian, Laurent, additional, Kaplanski, Gilles, additional, and Dignat-George, Françoise, additional

Published
2020
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17. Volume plaquettaire moyen et dysfonction de la fistule artério-veineuse dans une cohorte prospective de patients hémodialysés chroniques

Author

Lano, Guillaume, Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), and Stephane Burtey

Subjects
Platelets, Dysfonction et thrombose de FAV, AVF dysfunction and thrombosis, Hémodialyse, Hemodialysis, Plaquette, [SDV]Life Sciences [q-bio], MPV, VPM, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Thèse présentée sous la forme d'une" thèse article"; Introduction: Arteriovenous fistula (AVF) is the vascular access of 78% of haemodialysis patients in France. AVF dysfunctions such as thrombosis or stenosis are common complications. They are responsible for 30% of hospitalizations of chronic haemodialysis patients. One of the main factors behind these dysfunctions is an abnormality of hyperactive platelet-dependent coagulation during chronic renal failure. The more excitable young platelets are larger. Mean platelet volume (MPV) is a risk marker for major cardiovascular events.Objectives: Prospectively study MPV in our cohort of chronic haemodialysis as predictive marker of AVF dysfunction (occurrence of stenosis and acute thrombosis). We will study the mortality, the occurrence of cardiovascular events and serious haemorrhagic events.Materials and methods: The study included all chronic haemodialysis patients from the Conception Hospital at the CHU of Marseille between June 2014 and June 2016, component 226 patients. The main objective was to observe if there is a difference in the incidence of events on the AVF as dependent of the MPV. The population was divided according to 4 MPV levels determined by MPV quartiles in our cohort. The primary endpoint is a composite element called " AVF event" grouping: AVF acute thrombosis and AVF dysfunction requiring fistulography with endovascular treatment. Statistical analysis was done univarially by a Kaplan-Meier survival model and multivariate by a COX modelResults: 193 patients were included in the study with a median follow-up of 620 days. The median VPM was 10.8 fl [7.8-13.5] and the following quartiles: group 1: VPM ≤ 10fl, group 2: 10.1fl ≤ VPM

Published
2018

19. CD16/FC gamma R PROFILING ALLOWS NON INVASIVE APPRAISAL OF ANTIBODY-DEPENDENT NK CELL ALLOREACTIVE POTENTIAL IN HEART AND KIDNEY TRANSPLANT RECIPIENTS

Author

Picard, Christophe, Sampol, Emmanuelle, Legris, Tristan, Lyonnet, Luc, Dicristofaro, Julie, Lano, Guillaume, Moal, Valerie, DANIEL, Laurent, Burtey, Stéphane, Dignat-George, Francoise, Sabatier, Florence, Dussol, Bertrand, Mouly-Bandini, Annick, Paul, Pascale, Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), CIC biothérapies CBT 0503 [Nantes], Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Vascular research center of Marseille (VRCM), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), UMR 6578 : Anthropologie Bio-Culturelle (UAABC), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie de l'Endothelium, Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Cardiaque Adultes, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), and COMBE, Isabelle

Subjects
[SDV] Life Sciences [q-bio], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2017

20. Pseudo-hyperkalaemia in ambulatory samples: the never-ending story?

Author

Lano, Guillaume, Lefevre, Flora, Buffat, Christophe, Schlegel, Laurent, Dho, Emmanuel, Jantzen, Rodolphe, Resseguier, Noémie, and Robert, Thomas

Subjects
METEOROLOGICAL research
Abstract

R Foundation for Statistical Computing, Vienna, Austria 2021 Google Scholar Google Preview OpenURL Placeholder Text WorldCat COPAC 5 Oddoze C, Lombard E, Portugal H. Stability study of 81 analytes in human whole blood, in serum and in plasma. When samples are preserved at +4°C, we observed a significant elevation of kalaemia by inhibition of NA/K adenosine triphosphate (ATP) ase = NA/L ATPase (NaK-ATPase) in <2 h [[5]]. Physicians never know where blood samples are collected, nor whether the official recommendations for blood collection and storage temperatures have been applied. [Extracted from the article]

Published
2022
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24. Triage of Patients Suspected of COVID-19 in Chronic Hemodialysis: Eosinophil Count Differentiates Low and High Suspicion of COVID-19.

Author

Vial, Romain, Gully, Marion, Bobot, Mickael, Scarfoglière, Violaine, Brunet, Philippe, Bouchouareb, Dammar, Duval, Ariane, Zino, He-oh, Faraut, Julien, Jehel, Océane, Berdad-Haddad, Yaël, Burtey, Stéphane, Jarrot, Pierre-André, Lano, Guillaume, and Robert, Thomas

Subjects
COVID-19, MEDICAL triage, RECEIVER operating characteristic curves, BLOOD cell count, SARS-CoV-2
Abstract

Background: Daily management to shield chronic dialysis patients from SARS-CoV-2 contamination makes patient care cumbersome. There are no screening methods to date and a molecular biology platform is essential to perform RT-PCR for SARS-CoV-2; however, accessibility remains poor. Our goal was to assess whether the tools routinely used to monitor our hemodialysis patients could represent reliable and quickly accessible diagnostic indicators to improve the management of our hemodialysis patients in this pandemic environment. Methods: In this prospective observational diagnostic study, we recruited patients from La Conception hospital. Patients were eligible for inclusion if suspected of SARS-CoV-2 infection when arriving at our center for a dialysis session between March 12th and April 24th 2020. They were included if both RT-PCR result for SARS-CoV-2 and cell blood count on the day that infection was suspected were available. We calculated the area under the curve (AUC) of the receiver operating characteristic curve. Results: 37 patients were included in the final analysis, of which 16 (43.2%) were COVID-19 positive. For the day of suspected COVID-19, total leukocytes were significantly lower in the COVID-19 positive group (4.1 vs. 7.4 G/L, p = 0.0072) and were characterized by lower neutrophils (2.7 vs. 5.1 G/L, p = 0.021) and eosinophils (0.01 vs. 0.15 G/L, p = 0.0003). Eosinophil count below 0.045 G/L identified SARS-CoV-2 infection with AUC of 0.9 [95% CI 0.81—1] (p < 0.0001), sensitivity of 82%, specificity of 86%, a positive predictive value of 82%, a negative predictive value of 86% and a likelihood ratio of 6.04. Conclusions: Eosinophil count enables rapid routine screening of symptomatic chronic hemodialysis patients suspected of being COVID-19 within a range of low or high probability. [ABSTRACT FROM AUTHOR]

Published
2021
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