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1. Acute revascularization treatments for ischemic stroke in the Stroke Units of Triveneto, northeast Italy: time to treatment and functional outcomes

Author

Cappellari, Manuel, Bonetti, Bruno, Forlivesi, Stefano, Sajeva, Giulia, Naccarato, Marcello, Caruso, Paola, Lorenzut, Simone, Merlino, Giovanni, Viaro, Federica, Pieroni, Alessio, Giometto, Bruno, Bignamini, Valeria, Perini, Francesco, De Boni, Antonella, Morra, Michele, Critelli, Adriana, Tamborino, Carmine, Tonello, Simone, Guidoni, Silvia Vittoria, L’Erario, Roberto, Russo, Monia, Burlina, Alessandro, Turinese, Emanuele, Passadore, Paolo, Zanet, Luca, Polo, Alberto, Turazzini, Michelangelo, Basile, Anna Maria, Atzori, Matteo, Marini, Bruno, Bruno, Martina, Carella, Simona, Campagnaro, Alessandro, Baldi, Antonio, Corazza, Elisa, Zanette, Giampietro, Idone, Domenico, Gaudenzi, Anna, Bombardi, Roberto, Cadaldini, Morena, Lanzafame, Salvatore, Ferracci, Franco, Zambito, Sandro, Ruzza, Giampietro, Simonetto, Marco, Menegazzo, Elisabetta, Masato, Maela, Padoan, Roberta, Bozzato, Giulio, Paladin, Francesco, Tonon, Agnese, and Bovi, Paolo

Published
2021
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2. Supplementary Data 6 from Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Author

Ragusa, Marco, primary, Majorana, Alessandra, primary, Statello, Luisa, primary, Maugeri, Marco, primary, Salito, Loredana, primary, Barbagallo, Davide, primary, Guglielmino, Maria Rosa, primary, Duro, Laura R., primary, Angelica, Rosario, primary, Caltabiano, Rosario, primary, Biondi, Antonio, primary, Di Vita, Maria, primary, Privitera, Giuseppe, primary, Scalia, Marina, primary, Cappellani, Alessandro, primary, Vasquez, Enrico, primary, Lanzafame, Salvatore, primary, Basile, Francesco, primary, Di Pietro, Cinzia, primary, and Purrello, Michele, primary

Published
2023
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3. Supplementary Data Legends from Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Author

Ragusa, Marco, primary, Majorana, Alessandra, primary, Statello, Luisa, primary, Maugeri, Marco, primary, Salito, Loredana, primary, Barbagallo, Davide, primary, Guglielmino, Maria Rosa, primary, Duro, Laura R., primary, Angelica, Rosario, primary, Caltabiano, Rosario, primary, Biondi, Antonio, primary, Di Vita, Maria, primary, Privitera, Giuseppe, primary, Scalia, Marina, primary, Cappellani, Alessandro, primary, Vasquez, Enrico, primary, Lanzafame, Salvatore, primary, Basile, Francesco, primary, Di Pietro, Cinzia, primary, and Purrello, Michele, primary

Published
2023
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4. Supplementary Data 3 from Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Author

Ragusa, Marco, primary, Majorana, Alessandra, primary, Statello, Luisa, primary, Maugeri, Marco, primary, Salito, Loredana, primary, Barbagallo, Davide, primary, Guglielmino, Maria Rosa, primary, Duro, Laura R., primary, Angelica, Rosario, primary, Caltabiano, Rosario, primary, Biondi, Antonio, primary, Di Vita, Maria, primary, Privitera, Giuseppe, primary, Scalia, Marina, primary, Cappellani, Alessandro, primary, Vasquez, Enrico, primary, Lanzafame, Salvatore, primary, Basile, Francesco, primary, Di Pietro, Cinzia, primary, and Purrello, Michele, primary

Published
2023
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5. Supplementary Data 4 from Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Author

Ragusa, Marco, primary, Majorana, Alessandra, primary, Statello, Luisa, primary, Maugeri, Marco, primary, Salito, Loredana, primary, Barbagallo, Davide, primary, Guglielmino, Maria Rosa, primary, Duro, Laura R., primary, Angelica, Rosario, primary, Caltabiano, Rosario, primary, Biondi, Antonio, primary, Di Vita, Maria, primary, Privitera, Giuseppe, primary, Scalia, Marina, primary, Cappellani, Alessandro, primary, Vasquez, Enrico, primary, Lanzafame, Salvatore, primary, Basile, Francesco, primary, Di Pietro, Cinzia, primary, and Purrello, Michele, primary

Published
2023
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6. Supplementary Data 2 from Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Author

Ragusa, Marco, primary, Majorana, Alessandra, primary, Statello, Luisa, primary, Maugeri, Marco, primary, Salito, Loredana, primary, Barbagallo, Davide, primary, Guglielmino, Maria Rosa, primary, Duro, Laura R., primary, Angelica, Rosario, primary, Caltabiano, Rosario, primary, Biondi, Antonio, primary, Di Vita, Maria, primary, Privitera, Giuseppe, primary, Scalia, Marina, primary, Cappellani, Alessandro, primary, Vasquez, Enrico, primary, Lanzafame, Salvatore, primary, Basile, Francesco, primary, Di Pietro, Cinzia, primary, and Purrello, Michele, primary

Published
2023
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7. Supplementary Data 7 from Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Author

Ragusa, Marco, primary, Majorana, Alessandra, primary, Statello, Luisa, primary, Maugeri, Marco, primary, Salito, Loredana, primary, Barbagallo, Davide, primary, Guglielmino, Maria Rosa, primary, Duro, Laura R., primary, Angelica, Rosario, primary, Caltabiano, Rosario, primary, Biondi, Antonio, primary, Di Vita, Maria, primary, Privitera, Giuseppe, primary, Scalia, Marina, primary, Cappellani, Alessandro, primary, Vasquez, Enrico, primary, Lanzafame, Salvatore, primary, Basile, Francesco, primary, Di Pietro, Cinzia, primary, and Purrello, Michele, primary

Published
2023
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8. Supplementary Data 1 from Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Author

Ragusa, Marco, primary, Majorana, Alessandra, primary, Statello, Luisa, primary, Maugeri, Marco, primary, Salito, Loredana, primary, Barbagallo, Davide, primary, Guglielmino, Maria Rosa, primary, Duro, Laura R., primary, Angelica, Rosario, primary, Caltabiano, Rosario, primary, Biondi, Antonio, primary, Di Vita, Maria, primary, Privitera, Giuseppe, primary, Scalia, Marina, primary, Cappellani, Alessandro, primary, Vasquez, Enrico, primary, Lanzafame, Salvatore, primary, Basile, Francesco, primary, Di Pietro, Cinzia, primary, and Purrello, Michele, primary

Published
2023
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9. Supplementary Data 5 from Specific Alterations of MicroRNA Transcriptome and Global Network Structure in Colorectal Carcinoma after Cetuximab Treatment

Author

Ragusa, Marco, primary, Majorana, Alessandra, primary, Statello, Luisa, primary, Maugeri, Marco, primary, Salito, Loredana, primary, Barbagallo, Davide, primary, Guglielmino, Maria Rosa, primary, Duro, Laura R., primary, Angelica, Rosario, primary, Caltabiano, Rosario, primary, Biondi, Antonio, primary, Di Vita, Maria, primary, Privitera, Giuseppe, primary, Scalia, Marina, primary, Cappellani, Alessandro, primary, Vasquez, Enrico, primary, Lanzafame, Salvatore, primary, Basile, Francesco, primary, Di Pietro, Cinzia, primary, and Purrello, Michele, primary

Published
2023
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10. A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas

Author

Caltabiano, Rosario, Magro, Gaetano, Polizzi, Agata, Praticò, Andrea Domenico, Ortensi, Andrea, D’Orazi, Valerio, Panunzi, Andrea, Milone, Pietro, Maiolino, Luigi, Nicita, Francesco, Capone, Gabriele Lorenzo, Sestini, Roberta, Paganini, Irene, Muglia, Mariella, Cavallaro, Sebastiano, Lanzafame, Salvatore, Papi, Laura, and Ruggieri, Martino

Published
2017
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12. Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors

Author

Ragusa, Marco, Statello, Luisa, Maugeri, Marco, Majorana, Alessandra, Barbagallo, Davide, Salito, Loredana, Sammito, Mariangela, Santonocito, Manuela, Angelica, Rosario, Cavallaro, Andrea, Scalia, Marina, Caltabiano, Rosario, Privitera, Giuseppe, Biondi, Antonio, Di Vita, Maria, Cappellani, Alessandro, Vasquez, Enrico, Lanzafame, Salvatore, Tendi, Elisabetta, Celeste, Salvatore, Di Pietro, Cinzia, Basile, Francesco, and Purrello, Michele

Published
2012
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14. Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury

Author

Acquaviva, Rosaria, Lanteri, Raffaele, Li Destri, Giovanni, Caltabiano, Rosario, Vanella, Luca, Lanzafame, Salvatore, Di Cataldo, Antonio, Li Volti, Giovanni, and Di Giacomo, Claudia

Subjects
Arginine -- Dosage and administration, Reperfusion injury -- Drug therapy, Reperfusion injury -- Development and progression, Liver -- Properties, Biological sciences
Abstract

Reperfusion following liver ischemia results in oxidative stress leading to liver injury. The aim of this study was to investigate the combined effects of two antioxidant agents, rutin and L-arginine, in rat liver ischemia-reperfusion (I/R). Male Wistar rats were divided into five groups: 1) sham operated, 2) I/R, 3) I/R + rutin, 4) I/R + L-arginine, and 5) I/R + rutin + L-arginine. Plasmatic and hepatic levels of alanine transaminase (ALT), aspartate transaminase (AST), lipid peroxides (LOOH), and thiol groups (RSH) were examined, as well as DNA fragmentation and liver histopathology. Furthermore, to elucidate the pathophysiological processes involved in the antioxidant mechanism(s) of turin and L-arginine, we assessed the expression of inducible (iNOS) and endothelial nitric oxide synthase (eNOS) isoforms and heme oxygenase-1 (HO-1), both playing key roles in the biochemical cascade of liver injury. Significant increase in plasmatic ALT and AST activities were observed in untreated I/R rats compared with sham-operated animals, whereas treatment with rutin or L-arginine in I/R rats reduced hepatic damage. Interestingly, combined therapy with rutin and L-arginine resulted in a further reduction of plasmatic ALT and AST activities compared with rutin or L-arginine alone. These results were further confirmed by the analysis of DNA fragmentation, LOOH, RSH groups, and liver histopathology, which showed the highest protective effects following the coadministration of rutin and L-arginine. Finally, the combined therapy protocol resulted in a significant induction of liver HO-1 and a concomitant reduction of iNOS expression that may both be responsible for the beneficial effects of the proposed pharmacological protocol. heme oxygenase; nitric oxide synthase; oxidative stress; total thiol groups; lipid hydroperoxides; DNA damage; polyphenols

Published
2009

16. Spinal Neurofibromatosis with Central Nervous System Involvement in a Set of Twin Girls and a Boy: Further Expansion of the Phenotype

Author

Ruggieri, Martino, Polizzi, Agata, Salpietro, Vincenzo, Incorpora, Gemma, Nicita, Francesco, Pavone, Piero, Falsaperla, Raffaele, Nucifora, Caterina, Granata, Francesca, Distefano, Angela, Padua, Luca, Caltabiano, Rosario, Lanzafame, Salvatore, Gabriele, Anna Lia, Ortensi, Andrea, DʼOrazi, Valerio, Panunzi, Andrea, Milone, Pietro, Mankad, Kshitij, Platania, Nunzio, Albanese, Vincenzo, and Pavone, Vito

Published
2013
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20. Acute revascularization treatments for ischemic stroke in the Stroke Units of Triveneto, northeast Italy: time to treatment and functional outcomes

Author

Cappellari, Manuel, primary, Bonetti, Bruno, additional, Forlivesi, Stefano, additional, Sajeva, Giulia, additional, Naccarato, Marcello, additional, Caruso, Paola, additional, Lorenzut, Simone, additional, Merlino, Giovanni, additional, Viaro, Federica, additional, Pieroni, Alessio, additional, Giometto, Bruno, additional, Bignamini, Valeria, additional, Perini, Francesco, additional, De Boni, Antonella, additional, Morra, Michele, additional, Critelli, Adriana, additional, Tamborino, Carmine, additional, Tonello, Simone, additional, Guidoni, Silvia Vittoria, additional, L’Erario, Roberto, additional, Russo, Monia, additional, Burlina, Alessandro, additional, Turinese, Emanuele, additional, Passadore, Paolo, additional, Zanet, Luca, additional, Polo, Alberto, additional, Turazzini, Michelangelo, additional, Basile, Anna Maria, additional, Atzori, Matteo, additional, Marini, Bruno, additional, Bruno, Martina, additional, Carella, Simona, additional, Campagnaro, Alessandro, additional, Baldi, Antonio, additional, Corazza, Elisa, additional, Zanette, Giampietro, additional, Idone, Domenico, additional, Gaudenzi, Anna, additional, Bombardi, Roberto, additional, Cadaldini, Morena, additional, Lanzafame, Salvatore, additional, Ferracci, Franco, additional, Zambito, Sandro, additional, Ruzza, Giampietro, additional, Simonetto, Marco, additional, Menegazzo, Elisabetta, additional, Masato, Maela, additional, Padoan, Roberta, additional, Bozzato, Giulio, additional, Paladin, Francesco, additional, Tonon, Agnese, additional, and Bovi, Paolo, additional

Published
2020
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26. The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

Author

Li Destri Giovanni, Santagati Maria, Bertuccio Taschia, Cafiso Viviana, La Cava Piera, Palumbo Giuseppe A, Tandurella Igor, Triberio Patrizio, D'Agostino Vito, Valenti Salvo, Pernagallo Salvo, Tomasello Luisa, Salito Loredana, Statello Luisa, Scalia Marina, Angelica Rosario, Majorana Alessandra, Guglielmino Maria R, Duro Laura R, Barbagallo Davide, Ragusa Marco, Di Pietro Cinzia, Lanzafame Salvatore, Di Raimondo Francesco, Stefani Stefania, Mishra Bud, and Purrello Michele

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Apoptosis is a critical biological phenomenon, executed under the guidance of the Apoptotic Machinery (AM), which allows the physiologic elimination of terminally differentiated, senescent or diseased cells. Because of its relevance to BioMedicine, we have sought to obtain a detailed characterization of AM Omics in Homo sapiens, namely its Genomics and Evolution, Transcriptomics, Proteomics, Interactomics, Oncogenomics, and Pharmacogenomics. Methods This project exploited the methodology commonly used in Computational Biology (i.e., mining of many omics databases of the web) as well as the High Throughput biomolecular analytical techniques. Results In Homo sapiens AM is comprised of 342 protein-encoding genes (possessing either anti- or pro-apoptotic activity, or a regulatory function) and 110 MIR-encoding genes targeting them: some have a critical role within the system (core AM nodes), others perform tissue-, pathway-, or disease-specific functions (peripheral AM nodes). By overlapping the cancer type-specific AM mutation map in the fourteen most frequent cancers in western societies (breast, colon, kidney, leukaemia, liver, lung, neuroblastoma, ovary, pancreas, prostate, skin, stomach, thyroid, and uterus) to their transcriptome, proteome and interactome in the same tumour type, we have identified the most prominent AM molecular alterations within each class. The comparison of the fourteen mutated AM networks (both protein- as MIR-based) has allowed us to pinpoint the hubs with a general and critical role in tumour development and, conversely, in cell physiology: in particular, we found that some of these had already been used as targets for pharmacological anticancer therapy. For a better understanding of the relationship between AM molecular alterations and pharmacological induction of apoptosis in cancer, we examined the expression of AM genes in K562 and SH-SY5Y after anticancer treatment. Conclusion We believe that our data on the Apoptotic Machinery will lead to the identification of new cancer genes and to the discovery of new biomarkers, which could then be used to profile cancers for diagnostic purposes and to pinpoint new targets for pharmacological therapy. This approach could pave the way for future studies and applications in molecular and clinical Medicine with important perspectives both for Oncology as for Regenerative Medicine.

Published
2009
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27. Expression pattern of estroprogestinic receptors in sinonasal inverted papilloma

Author

Serra, Agostino, primary, Caltabiano, Rosario, additional, Spinato, Giacomo, additional, Gallina, Salvatore, additional, Caruso, Salvatore, additional, Rapisarda, Venerando, additional, Di Mauro, Paola, additional, Castro, Veronica, additional, Conti, Angelo, additional, Licciardello, Luisa, additional, Maiolino, Luigi, additional, Lanzafame, Salvatore, additional, and Cocuzza, Salvatore, additional

Published
2017
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29. Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme

Author

Barbagallo, Davide, primary, Condorelli, Angelo, additional, Ragusa, Marco, additional, Salito, Loredana, additional, Sammito, Mariangela, additional, Banelli, Barbara, additional, Caltabiano, Rosario, additional, Barbagallo, Giuseppe, additional, Zappalà, Agata, additional, Battaglia, Rosalia, additional, Cirnigliaro, Matilde, additional, Lanzafame, Salvatore, additional, Vasquez, Enrico, additional, Parenti, Rosalba, additional, Cicirata, Federico, additional, Di Pietro, Cinzia, additional, Romani, Massimo, additional, and Purrello, Michele, additional

Published
2015
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31. Isolated Laryngeal Leishmaniasis in Immunocompetent Patients: An Underdiagnosed Disease

Author

Cocuzza, Salvatore, Strazzulla, Alessio, Pinzone, Marilia Rita, Cosentino, Stefano, Serra, Agostino, Caltabiano, Rosario, Lanzafame, Salvatore, Cacopardo, Bruno, and Nunnari, Giuseppe

Subjects
Article Subject
Abstract

We describe a case of isolated primary laryngeal leishmaniasis in an immunocompetent Italian patient with a previous medical history negative for visceral or cutaneous leishmaniasis, presenting with hoarseness. We also summarize the epidemiological, clinical, and diagnostic features and the therapeutic management of other cases of laryngeal leishmaniasis in immunocompetent subjects, described in the literature. Considering the insidious and nonspecific clinical presentation, the increasing number of different forms of mild or underestimated immunosuppressive conditions, and the number of people travelling in endemic zones, along with the ability of Leishmania amastigotes to survive for a long period in the body, we believe it is important for pathologists and clinicians to be aware of this unusual form of leishmaniasis in order to avoid delayed recognition and treatment. The rarity of the presentation and the lack of guidelines on mucosal leishmaniasis may contribute to the potential undiagnosed cases or delayed diagnosis, the possible relapses, as well as the correct pharmacological and/or surgical therapeutic approach.

Published
2013
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32. Prove di sensibilità pupillare alla pilocarpina in pazienti con malattia di Parkinson ed atrofia multisistemica

Author

Lanzafame, Salvatore

Subjects
Area 06 - Scienze mediche, Parkinson s disease, eye drop test, pupillary response, visual disturbance, pilocarpine
Abstract

La malattia di Parkinson si associa a sintomi disautonomici, sia in fase avanzata che precoce. Pochi sono gli studi che hanno avuto come oggetto la disfunzione autonomica pupillare nella malattia di Parkinson e nei parkinsonismi. In questo lavoro, abbiamo voluto esaminare la sensibilità pupillare alla somministrazione di pilocarpina (agente parasimpatico-mimetico) in soggetti affetti da malattia di Parkinson e con atrofia multisistemica. Sono stati arruolati 20 pazienti con malattia di Parkinson, 18 pazienti con atrofia multisistemica e 16 soggetti controllo. Il diametro pupillare basale era significativamente maggiore nel gruppo dei soggetti con MP rispetto sia al gruppo controllo (p value 0,03, Mann-Whitney U Test) che al gruppo AMS (p value 0,05). Inoltre, la riposta miotica alla pilocarpina era significativamente maggiore in termini di ampiezza nel gruppo MP rispetto ai controlli (p value 0,01) e ai pazienti con MSA (p-value 0.001). Questi dati supportano l'ipotesi di una disfunzione pupillare (sul versante parasimpatico) nella malattia di Parkinson oltre a fornire un interessante spunto nella diagnosi differenziale dei parkinsonismi.

Published
2012

34. Specific Alterations of the MicroRNA Transcriptome, its Target Proteome, and Global Network Structure in CRC after Treatment with MAPKs inhibitors

Author

Ragusa, Marco, Statello, L, Majorana, A, Maugeri, M, Barbagallo, Davide, Duro, L. R., Guglielmino, M. R., Angelica, R, Salito, L, Santonocito, M, Sammito, M, Cavallaro, A, Scalia, M, Caltabiano, Rosario, Privitera, Giuseppe, Biondi, Antonio Giuseppe, Di Vita, M, Cappellani, A, Vasquez, E, Lanzafame, Salvatore, Tendi, E, Mishra, B, DI PIETRO, Cinzia Santa, Basile, Francesco, and Purrello, Michele

Published
2011

40. Ovarian masses: Evaluation with diffusion weighted MR imaging

Author

Foti, Pietro Valerio, Farina, R, D'Aniello, D, Milone, Pietro, Zarbo, G, Lanzafame, Salvatore, Caltabiano, Rosario, Politi, G, and Ettorre, Gc

Subjects
Apparent diffusion coefficient, Genitourinary - Female, Obstetrics (Pregnancy / birth / postnatal period), Diffusion weighted MRI, Apparent diffusion coefficient, Ovarian masses, Diffusion weighted MRI, Ovarian masses, Genital / Reproductive system female, Pelvis
Abstract

Purpose Methods and Materials Results Conclusion References Personal Information, Purpose: To prospectively evaluate the diagnostic capabilities of diffusion weighted Magnetic Resonance Imaging (DWMRI) in characterizing ovarian...

Published
2010
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41. MicroRNA expression profile and network in colorectal carcinoma after chemotherapy

Author

Ragusa, Marco, Majorana, A., Statello, L., Salito, L., Barbagallo, D, Guglielmino, Mr, Duro, L, Angelica, R, Caltabiano, Rosario, Biondi, Antonio Giuseppe, DE VITA, M., Privitera, Giuseppe, Cappellani, A., Vasquez, E., Lanzafame, Salvatore, Basile, Francesco, DI PIETRO, Cinzia Santa, and Purrello, Michele

Published
2010

42. MR staging of endometrial cancer: Radiologic-pathologic correlation and cause of pitfalls

Author

Foti, P. V., Farina, R., Palmucci, Stefano, Ruggeri, C., Zarbo, G., Lanzafame, Salvatore, Caltabiano, Rosario, Politi, G., and Ettorre, G. C.

Subjects
radiologic-pathologic correlation, Genitourinary - Female, Obstetrics (Pregnancy / birth / postnatal period), endometrial cancer, MRI, endometrial cancer, radiologic-pathologic correlation, Genital / Reproductive system female, Pelvis, MRI
Abstract

Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References, Learning objectives: To show the diagnostic performance and findings of Magnetic Resonance Imaging (MRI) in the staging of endometrial cancer and correlate them with histopathologic findings. To describe the possible causes of misdiagnosis in staging carcinoma of the...

Published
2010

45. Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic Considerations

Author

Amico, Paolo, Lanzafame, Salvatore, Li Destri, Giovanni, Greco, Paolo, Caltabiano, Rosario, Vecchio, Giada Maria, and Magro, Gaetano

Subjects
Article Subject
Abstract

Warthin tumor-like papillary thyroid carcinoma is an uncommon variant of papillary thyroid carcinoma. We report a rare case of Warthin tumor-like variant of papillary thyroid carcinoma with a dedifferentiated component consisting of a solid tumor area composed of neoplastic cells with a spindle to tall cell morphology associated with marked nuclear pleomorphism, atypical mitoses, and foci of necrosis. Although our patient presented with a locally aggressive disease (T3 N1b Mo), she is disease-free without radioiodine therapy after a 23-month follow-up period. We emphasize that Warthin tumor-like papillary thyroid carcinoma, like other morphological variants of papillary carcinoma, may occasionally undergo dedifferentiation. As this component may be only focally detectable, we suggest an extensive sampling of all large-sized (>3 cm) papillary thyroid carcinoma. Recognition of any dedifferentiated component in a Warthin tumor-like papillary thyroid carcinoma should be reported, including its percentage, because it may reflect a more aggressive clinical course.

Published
2010
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48. Discordance rate of HER2 status in primary breast carcinomas versus synchronous axillary lymph node metastases: a multicenter retrospective investigation

Author

Ieni,Antonio, Barresi,Valeria, Caltabiano,Rosario, Cascone,Anna Maria, Del Sordo,Rachele, Cabibi,Daniela, Zeppa,Pio, Lanzafame,Salvatore, Sidoni,Angelo, Franco,Vito, Tuccari,Giovanni, Ieni,Antonio, Barresi,Valeria, Caltabiano,Rosario, Cascone,Anna Maria, Del Sordo,Rachele, Cabibi,Daniela, Zeppa,Pio, Lanzafame,Salvatore, Sidoni,Angelo, Franco,Vito, and Tuccari,Giovanni

Abstract

Antonio Ieni,1 Valeria Barresi,1 Rosario Caltabiano,2 Anna Maria Cascone,3 Rachele Del Sordo,4 Daniela Cabibi,5 Pio Zeppa,3 Salvatore Lanzafame,2 Angelo Sidoni,4 Vito Franco,5 Giovanni Tuccari1 1Department of Human Pathology Gaetano Barresi, Section of Anatomic Pathology, University of Messina, Messina, 2Department GF Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, 3Department of Medicine and Surgery, University of Salerno, Salerno, 4Institute of Pathologic Anatomy and Histology, Division of Cancer Research, University of Perugia, Perugia, 5Department of Human Pathology, Section of Anatomic Pathology, University of Palermo, Palermo, Italy Background: Human epidermal growth factor receptor 2 (HER2) is considered to be a therapeutic and prognostic marker in the management of breast carcinoma (BC), although discordance rates between primary and metastatic or locally recurrent lesions have been reported. Methods: One hundred and forty-eight paraffin-embedded BC tissues from patients of mean age 59.27 (33–96) years and corresponding synchronous lymph node metastases were collected and retrospectively studied using immunohistochemistry and fluorescence in situ hybridization to evaluate HER2 status. Fleiss-Cohen weighted k statistics were used to assess the concordance rate between HER2 status of the primary BC and the synchronous metastatic lesions. Results: The overall concordance rate for HER2 was 95.28%. Eighty-nine cases were concordantly HER2-negative in primary BC and nodal metastases, and 52 cases were HER2-positive in both primary and metastatic tumors. Changes in HER2 status between primary BC and corresponding synchronous metastases were observed in seven (4.72%) cases. Three of the discordant cases were HER2-negative in the primary tumor and HER2-positive in the metastases, while four cases were HER2-positive in the primary BC and HER2-negative in the metastases. No significant correlations were identified between HER2 status

Published
2014

50. Long-term therapy with temozolomide is a feasible option for newly diagnosed glioblastoma: a single-institution experience with as many as 101 temozolomide cycles

Author

Barbagallo, Giuseppe M. V., primary, Paratore, Sabrina, additional, Caltabiano, Rosario, additional, Palmucci, Stefano, additional, Parra, Hector Soto, additional, Privitera, Giuseppe, additional, Motta, Fabio, additional, Lanzafame, Salvatore, additional, Scaglione, Giorgio, additional, Longo, Antonio, additional, Albanese, Vincenzo, additional, and Certo, Francesco, additional

Published
2014
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