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315 results on '"Laoui, Damya"'

1. Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

Author

Hamouda, Ahmed E. I., Filtjens, Jessica, Brabants, Elisabeth, Kancheva, Daliya, Debraekeleer, Ayla, Brughmans, Jan, Jacobs, Lotte, Bardet, Pauline M. R., Knetemann, Elisabeth, Lefesvre, Pierre, Allonsius, Lize, Gontsarik, Mark, Varela, Ismael, Crabbé, Marian, Clappaert, Emile J., Cappellesso, Federica, Caro, Aarushi A., Gordún Peiró, Alícia, Fredericq, Luna, Hadadi, Eva, Estapé Senti, Mariona, Schiffelers, Raymond, van Grunsven, Leo A., Aboubakar Nana, Frank, De Geest, Bruno G., Deschoemaeker, Sofie, De Koker, Stefaan, Lambolez, Florence, and Laoui, Damya

Published
2024
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5. Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

Author

Hua, Yichao, Vella, Gerlanda, Rambow, Florian, Allen, Elizabeth, Antoranz Martinez, Asier, Duhamel, Marie, Takeda, Akira, Jalkanen, Sirpa, Junius, Steffie, Smeets, Ann, Nittner, David, Dimmeler, Stefanie, Hehlgans, Thomas, Liston, Adrian, Bosisio, Francesca Maria, Floris, Giuseppe, Laoui, Damya, Hollmén, Maija, Lambrechts, Diether, Merchiers, Pascal, Marine, Jean-Christophe, Schlenner, Susan, and Bergers, Gabriele

Published
2022
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6. Macrophages are metabolically heterogeneous within the tumor microenvironment

Author

Geeraerts, Xenia, Fernández-Garcia, Juan, Hartmann, Felix J., de Goede, Kyra E., Martens, Liesbet, Elkrim, Yvon, Debraekeleer, Ayla, Stijlemans, Benoit, Vandekeere, Anke, Rinaldi, Gianmarco, De Rycke, Riet, Planque, Mélanie, Broekaert, Dorien, Meinster, Elisa, Clappaert, Emile, Bardet, Pauline, Murgaski, Aleksandar, Gysemans, Conny, Nana, Frank Aboubakar, Saeys, Yvan, Bendall, Sean C., Laoui, Damya, Van den Bossche, Jan, Fendt, Sarah-Maria, and Van Ginderachter, Jo A.

Published
2021
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10. A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

Author

Qian, Junbin, Olbrecht, Siel, Boeckx, Bram, Vos, Hanne, Laoui, Damya, Etlioglu, Emre, Wauters, Els, Pomella, Valentina, Verbandt, Sara, Busschaert, Pieter, Bassez, Ayse, Franken, Amelie, Bempt, Marlies Vanden, Xiong, Jieyi, Weynand, Birgit, van Herck, Yannick, Antoranz, Asier, Bosisio, Francesca Maria, Thienpont, Bernard, Floris, Giuseppe, Vergote, Ignace, Smeets, Ann, Tejpar, Sabine, and Lambrechts, Diether

Published
2020
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13. Hapten/Myristoyl Functionalized Poly(propyleneimine) Dendrimers as Potent Cell Surface Recruiters of Antibodies for Mediating Innate Immune Killing

Author

Uvyn, Annemiek, primary, Vleugels, Marle Elisabeth Jacqueline, additional, de Waal, Bas, additional, Hamouda, Ahmed Emad Ibrahim, additional, Dhiman, Shikha, additional, Louage, Benoit, additional, Albertazzi, Lorenzo, additional, Laoui, Damya, additional, Meijer, E. W., additional, and De Geest, Bruno G., additional

Published
2023
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15. Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models

Author

Clappaert, Emile J., primary, Kancheva, Daliya, additional, Brughmans, Jan, additional, Debraekeleer, Ayla, additional, Bardet, Pauline M. R., additional, Elkrim, Yvon, additional, Lacroix, Dagmar, additional, Živalj, Maida, additional, Hamouda, Ahmed E.I., additional, Van Ginderachter, Jo A., additional, Deschoemaeker, Sofie, additional, and Laoui, Damya, additional

Published
2023
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18. Data from IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D

Author

Kiss, Máté, primary, Vande Walle, Lieselotte, primary, Saavedra, Pedro H.V., primary, Lebegge, Els, primary, Van Damme, Helena, primary, Murgaski, Aleksandar, primary, Qian, Junbin, primary, Ehling, Manuel, primary, Pretto, Samantha, primary, Bolli, Evangelia, primary, Keirsse, Jiri, primary, Bardet, Pauline M.R., primary, Arnouk, Sana M., primary, Elkrim, Yvon, primary, Schmoetten, Maryse, primary, Brughmans, Jan, primary, Debraekeleer, Ayla, primary, Fossoul, Amelie, primary, Boon, Louis, primary, Raes, Geert, primary, van Loo, Geert, primary, Lambrechts, Diether, primary, Mazzone, Massimiliano, primary, Beschin, Alain, primary, Wullaert, Andy, primary, Lamkanfi, Mohamed, primary, Van Ginderachter, Jo A., primary, and Laoui, Damya, primary

Published
2023
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19. Supplementary Figures 1-11 from IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D

Author

Kiss, Máté, primary, Vande Walle, Lieselotte, primary, Saavedra, Pedro H.V., primary, Lebegge, Els, primary, Van Damme, Helena, primary, Murgaski, Aleksandar, primary, Qian, Junbin, primary, Ehling, Manuel, primary, Pretto, Samantha, primary, Bolli, Evangelia, primary, Keirsse, Jiri, primary, Bardet, Pauline M.R., primary, Arnouk, Sana M., primary, Elkrim, Yvon, primary, Schmoetten, Maryse, primary, Brughmans, Jan, primary, Debraekeleer, Ayla, primary, Fossoul, Amelie, primary, Boon, Louis, primary, Raes, Geert, primary, van Loo, Geert, primary, Lambrechts, Diether, primary, Mazzone, Massimiliano, primary, Beschin, Alain, primary, Wullaert, Andy, primary, Lamkanfi, Mohamed, primary, Van Ginderachter, Jo A., primary, and Laoui, Damya, primary

Published
2023
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20. Supplementary Figure from Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages

Author

Murgaski, Aleksandar, primary, Kiss, Máté, primary, Van Damme, Helena, primary, Kancheva, Daliya, primary, Vanmeerbeek, Isaure, primary, Keirsse, Jiri, primary, Hadadi, Eva, primary, Brughmans, Jan, primary, Arnouk, Sana M., primary, Hamouda, Ahmed E.I., primary, Debraekeleer, Ayla, primary, Bosteels, Victor, primary, Elkrim, Yvon, primary, Boon, Louis, primary, Hoves, Sabine, primary, Vandamme, Niels, primary, Deschoemaeker, Sofie, primary, Janssens, Sophie, primary, Garg, Abhishek D., primary, Vande Velde, Greetje, primary, Schmittnaegel, Martina, primary, Ries, Carola H., primary, and Laoui, Damya, primary

Published
2023
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21. Supplementary Data from Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages

Author

Murgaski, Aleksandar, primary, Kiss, Máté, primary, Van Damme, Helena, primary, Kancheva, Daliya, primary, Vanmeerbeek, Isaure, primary, Keirsse, Jiri, primary, Hadadi, Eva, primary, Brughmans, Jan, primary, Arnouk, Sana M., primary, Hamouda, Ahmed E.I., primary, Debraekeleer, Ayla, primary, Bosteels, Victor, primary, Elkrim, Yvon, primary, Boon, Louis, primary, Hoves, Sabine, primary, Vandamme, Niels, primary, Deschoemaeker, Sofie, primary, Janssens, Sophie, primary, Garg, Abhishek D., primary, Vande Velde, Greetje, primary, Schmittnaegel, Martina, primary, Ries, Carola H., primary, and Laoui, Damya, primary

Published
2023
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22. Data from Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages

Author

Movahedi, Kiavash, primary, Schoonooghe, Steve, primary, Laoui, Damya, primary, Houbracken, Isabelle, primary, Waelput, Wim, primary, Breckpot, Karine, primary, Bouwens, Luc, primary, Lahoutte, Tony, primary, De Baetselier, Patrick, primary, Raes, Geert, primary, Devoogdt, Nick, primary, and Van Ginderachter, Jo A., primary

Published
2023
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23. Supplementary Figures 1 through 5 from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

Author

Laoui, Damya, primary, Van Overmeire, Eva, primary, Di Conza, Giusy, primary, Aldeni, Chiara, primary, Keirsse, Jiri, primary, Morias, Yannick, primary, Movahedi, Kiavash, primary, Houbracken, Isabelle, primary, Schouppe, Elio, primary, Elkrim, Yvon, primary, Karroum, Oussama, primary, Jordan, Bénédicte, primary, Carmeliet, Peter, primary, Gysemans, Conny, primary, De Baetselier, Patrick, primary, Mazzone, Massimiliano, primary, and Van Ginderachter, Jo A., primary

Published
2023
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24. Data from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

Author

Laoui, Damya, primary, Van Overmeire, Eva, primary, Di Conza, Giusy, primary, Aldeni, Chiara, primary, Keirsse, Jiri, primary, Morias, Yannick, primary, Movahedi, Kiavash, primary, Houbracken, Isabelle, primary, Schouppe, Elio, primary, Elkrim, Yvon, primary, Karroum, Oussama, primary, Jordan, Bénédicte, primary, Carmeliet, Peter, primary, Gysemans, Conny, primary, De Baetselier, Patrick, primary, Mazzone, Massimiliano, primary, and Van Ginderachter, Jo A., primary

Published
2023
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25. Supplementary Methods from Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages

Author

Movahedi, Kiavash, primary, Schoonooghe, Steve, primary, Laoui, Damya, primary, Houbracken, Isabelle, primary, Waelput, Wim, primary, Breckpot, Karine, primary, Bouwens, Luc, primary, Lahoutte, Tony, primary, De Baetselier, Patrick, primary, Raes, Geert, primary, Devoogdt, Nick, primary, and Van Ginderachter, Jo A., primary

Published
2023
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27. Supplementary Tables 1-5 from Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages

Author

Movahedi, Kiavash, primary, Schoonooghe, Steve, primary, Laoui, Damya, primary, Houbracken, Isabelle, primary, Waelput, Wim, primary, Breckpot, Karine, primary, Bouwens, Luc, primary, Lahoutte, Tony, primary, De Baetselier, Patrick, primary, Raes, Geert, primary, Devoogdt, Nick, primary, and Van Ginderachter, Jo A., primary

Published
2023
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28. Supplementary Video 3 from Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages

Author

Movahedi, Kiavash, primary, Schoonooghe, Steve, primary, Laoui, Damya, primary, Houbracken, Isabelle, primary, Waelput, Wim, primary, Breckpot, Karine, primary, Bouwens, Luc, primary, Lahoutte, Tony, primary, De Baetselier, Patrick, primary, Raes, Geert, primary, Devoogdt, Nick, primary, and Van Ginderachter, Jo A., primary

Published
2023
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29. Supplementary Video 2 from Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages

Author

Movahedi, Kiavash, primary, Schoonooghe, Steve, primary, Laoui, Damya, primary, Houbracken, Isabelle, primary, Waelput, Wim, primary, Breckpot, Karine, primary, Bouwens, Luc, primary, Lahoutte, Tony, primary, De Baetselier, Patrick, primary, Raes, Geert, primary, Devoogdt, Nick, primary, and Van Ginderachter, Jo A., primary

Published
2023
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30. Supplementary Figures S1-S9 from M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

Author

Van Overmeire, Eva, primary, Stijlemans, Benoît, primary, Heymann, Felix, primary, Keirsse, Jiri, primary, Morias, Yannick, primary, Elkrim, Yvon, primary, Brys, Lea, primary, Abels, Chloé, primary, Lahmar, Qods, primary, Ergen, Can, primary, Vereecke, Lars, primary, Tacke, Frank, primary, De Baetselier, Patrick, primary, Van Ginderachter, Jo A., primary, and Laoui, Damya, primary

Published
2023
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31. Supplementary Video 1 from Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages

Author

Movahedi, Kiavash, primary, Schoonooghe, Steve, primary, Laoui, Damya, primary, Houbracken, Isabelle, primary, Waelput, Wim, primary, Breckpot, Karine, primary, Bouwens, Luc, primary, Lahoutte, Tony, primary, De Baetselier, Patrick, primary, Raes, Geert, primary, Devoogdt, Nick, primary, and Van Ginderachter, Jo A., primary

Published
2023
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32. Supplementary Methods from M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

Author

Van Overmeire, Eva, primary, Stijlemans, Benoît, primary, Heymann, Felix, primary, Keirsse, Jiri, primary, Morias, Yannick, primary, Elkrim, Yvon, primary, Brys, Lea, primary, Abels, Chloé, primary, Lahmar, Qods, primary, Ergen, Can, primary, Vereecke, Lars, primary, Tacke, Frank, primary, De Baetselier, Patrick, primary, Van Ginderachter, Jo A., primary, and Laoui, Damya, primary

Published
2023
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33. Supplementary Figures 1-8, Video Legends 1-3 from Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages

Author

Movahedi, Kiavash, primary, Schoonooghe, Steve, primary, Laoui, Damya, primary, Houbracken, Isabelle, primary, Waelput, Wim, primary, Breckpot, Karine, primary, Bouwens, Luc, primary, Lahoutte, Tony, primary, De Baetselier, Patrick, primary, Raes, Geert, primary, Devoogdt, Nick, primary, and Van Ginderachter, Jo A., primary

Published
2023
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34. Supplementary Tables S1-S2 from M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

Author

Van Overmeire, Eva, primary, Stijlemans, Benoît, primary, Heymann, Felix, primary, Keirsse, Jiri, primary, Morias, Yannick, primary, Elkrim, Yvon, primary, Brys, Lea, primary, Abels, Chloé, primary, Lahmar, Qods, primary, Ergen, Can, primary, Vereecke, Lars, primary, Tacke, Frank, primary, De Baetselier, Patrick, primary, Van Ginderachter, Jo A., primary, and Laoui, Damya, primary

Published
2023
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35. Supplementary Tables 1 and 2 from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

Author

Laoui, Damya, primary, Van Overmeire, Eva, primary, Di Conza, Giusy, primary, Aldeni, Chiara, primary, Keirsse, Jiri, primary, Morias, Yannick, primary, Movahedi, Kiavash, primary, Houbracken, Isabelle, primary, Schouppe, Elio, primary, Elkrim, Yvon, primary, Karroum, Oussama, primary, Jordan, Bénédicte, primary, Carmeliet, Peter, primary, Gysemans, Conny, primary, De Baetselier, Patrick, primary, Mazzone, Massimiliano, primary, and Van Ginderachter, Jo A., primary

Published
2023
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36. Supplementary Materials, Tables 1-4, Figures 1-10 from Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

Author

Movahedi, Kiavash, primary, Laoui, Damya, primary, Gysemans, Conny, primary, Baeten, Martijn, primary, Stangé, Geert, primary, Van den Bossche, Jan, primary, Mack, Matthias, primary, Pipeleers, Daniel, primary, In't Veld, Peter, primary, De Baetselier, Patrick, primary, and Van Ginderachter, Jo A., primary

Published
2023
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37. Supplementary Methods from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

Author

Laoui, Damya, primary, Van Overmeire, Eva, primary, Di Conza, Giusy, primary, Aldeni, Chiara, primary, Keirsse, Jiri, primary, Morias, Yannick, primary, Movahedi, Kiavash, primary, Houbracken, Isabelle, primary, Schouppe, Elio, primary, Elkrim, Yvon, primary, Karroum, Oussama, primary, Jordan, Bénédicte, primary, Carmeliet, Peter, primary, Gysemans, Conny, primary, De Baetselier, Patrick, primary, Mazzone, Massimiliano, primary, and Van Ginderachter, Jo A., primary

Published
2023
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38. Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

Author

Hua, Yichao, primary, Vella, Gerlanda, additional, Rambow, Florian, additional, Allen, Elizabeth, additional, Martinez, Asier Antoranz, additional, Duhamel, Marie, additional, Takeda, Akira, additional, Jalkanen, Sirpa, additional, Junius, Steffie, additional, Smeets, Ann, additional, Nittner, David, additional, Dimmeler, Stefanie, additional, Hehlgans, Thomas, additional, Liston, Adrian, additional, Bosisio, Francesca Maria, additional, Floris, Giuseppe, additional, Laoui, Damya, additional, Hollmén, Maija, additional, Lambrechts, Diether, additional, Merchiers, Pascal, additional, Marine, Jean-Christophe, additional, Schlenner, Susan, additional, and Bergers, Gabriele, additional

Published
2023
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41. Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironment

Author

Kiss, Máté, primary, Lebegge, Els, additional, Murgaski, Aleksandar, additional, Van Damme, Helena, additional, Kancheva, Daliya, additional, Brughmans, Jan, additional, Scheyltjens, Isabelle, additional, Talebi, Ali, additional, Awad, Robin Maximilian, additional, Elkrim, Yvon, additional, Bardet, Pauline M. R., additional, Arnouk, Sana M., additional, Goyvaerts, Cleo, additional, Swinnen, Johan, additional, Nana, Frank Aboubakar, additional, Van Ginderachter, Jo A., additional, and Laoui, Damya, additional

Published
2022
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48. Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models.

Author

Clappaert, Emile J., Kancheva, Daliya, Brughmans, Jan, Debraekeleer, Ayla, Bardet, Pauline M. R., Elkrim, Yvon, Lacroix, Dagmar, Živalj, Maida, Hamouda, Ahmed E. I., Van Ginderachter, Jo A., Deschoemaeker, Sofie, and Laoui, Damya

Subjects
ANIMAL models in research, DENDRITIC cells, TUMOR growth, LUNG cancer, TUMOR treatment, CANCER cell growth
Abstract

Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that can increase DC abundance in the tumor when administered therapeutically. However, the impact of Flt3L on the phenotype of distinct cDC subsets in the tumor microenvironment is still largely undetermined. Here, using multi-omic single-cell analysis, we show that Flt3L therapy increases all cDC subsets in orthotopic E0771 and TS/A breast cancer and LLC lung cancer models, but this did not result in a reduction of tumor growth in any of the models. Interestingly, a CD81+migcDC1 population, likely developing from cDC1, was induced upon Flt3L treatment in E0771 tumors as well as in TS/A breast and LLC lung tumors. This CD81+migcDC1 subset is characterized by the expression of both canonical cDC1 markers as well as migratory cDC activation and regulatory markers and displayed a Treg-inducing potential. To shift the cDC phenotype towards a T-cell stimulatory phenotype, CD40 agonist therapy was administered to E0771 tumor-bearing mice in combination with Flt3L. However, while αCD40 reduced tumor growth, Flt3L failed to improve the therapeutic response to αCD40 therapy. Interestingly, Flt3L +αCD40 combination therapy increased the abundance of Treg-promoting CD81+migcDC1. Nonetheless, while Treg-depletion and αCD40 therapy were synergistic, the addition of Flt3L to this combination did not result in any added benefit. Overall, these results indicate that merely increasing cDCs in the tumor by Flt3L treatment cannot improve anti-tumor responses and therefore might not be beneficial for the treatment of cancer, though could still be of use to increase cDC numbers for autologous DC-therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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