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1. Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series).

Author

Molloy, Eleanor, El-Dib, Mohamed, Soul, Janet, Juul, Sandra, Gunn, Alistair, Bender, Manon, Bearer, Cynthia, Wu, Yvonne, Robertson, Nicola, Cotton, Mike, Branagan, Aoife, Hurley, Tim, Tan, Sidhartha, Laptook, Abbot, Austin, Topun, Mohammad, Khorshid, Rogers, Elizabeth, Luyt, Karen, Wintermark, Pia, Bonifacio, Sonia, and Gonzalez, Fernando

Subjects
Humans, Infant, Newborn, Infant, Premature, Intensive Care Units, Neonatal, Neuroprotective Agents, Neuroprotection, Brain Injuries
Abstract

The survival of preterm infants has steadily improved thanks to advances in perinatal and neonatal intensive clinical care. The focus is now on finding ways to improve morbidities, especially neurological outcomes. Although antenatal steroids and magnesium for preterm infants have become routine therapies, studies have mainly demonstrated short-term benefits for antenatal steroid therapy but limited evidence for impact on long-term neurodevelopmental outcomes. Further advances in neuroprotective and neurorestorative therapies, improved neuromonitoring modalities to optimize recruitment in trials, and improved biomarkers to assess the response to treatment are essential. Among the most promising agents, multipotential stem cells, immunomodulation, and anti-inflammatory therapies can improve neural outcomes in preclinical studies and are the subject of considerable ongoing research. In the meantime, bundles of care protecting and nurturing the brain in the neonatal intensive care unit and beyond should be widely implemented in an effort to limit injury and promote neuroplasticity. IMPACT: With improved survival of preterm infants due to improved antenatal and neonatal care, our focus must now be to improve long-term neurological and neurodevelopmental outcomes. This review details the multifactorial pathogenesis of preterm brain injury and neuroprotective strategies in use at present, including antenatal care, seizure management and non-pharmacological NICU care. We discuss treatment strategies that are being evaluated as potential interventions to improve the neurodevelopmental outcomes of infants born prematurely.

Published
2024

3. Neuroprotective therapies in the NICU in term infants: present and future.

Author

Molloy, Eleanor J, El-Dib, Mohamed, Juul, Sandra E, Benders, Manon, Gonzalez, Fernando, Bearer, Cynthia, Wu, Yvonne W, Robertson, Nicola J, Hurley, Tim, Branagan, Aoife, Michael Cotten, C, Tan, Sidhartha, Laptook, Abbot, Austin, Topun, Mohammad, Khorshid, Rogers, Elizabeth, Luyt, Karen, Bonifacio, Sonia, Soul, Janet S, Gunn, Alistair J, and Newborn Brain Society Guidelines and Publications Committee

Subjects
Newborn Brain Society Guidelines and Publications Committee, Humans, Brain Injuries, Hypoxia-Ischemia, Brain, Infant, Newborn, Diseases, Neuroprotective Agents, Hypothermia, Induced, Child, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Neuroprotection, Pediatric, Neurosciences, Neurodegenerative, Physical Injury - Accidents and Adverse Effects, Brain Disorders, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Good Health and Well Being, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics
Abstract

Outcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE in term and near-term infants has proven beneficial, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. There is therefore a critical need to find additional pharmacological and non-pharmacological interventions that improve the outcomes for these children. There are many potential candidates; however, it is unclear whether these interventions have additional benefits when used with TH. Although primary and delayed (secondary) brain injury starting in the latent phase after HI are major contributors to neurodisability, the very late evolving effects of tertiary brain injury likely require different interventions targeting neurorestoration. Clinical trials of seizure management and neuroprotection bundles are needed, in addition to current trials combining erythropoietin, stem cells, and melatonin with TH. IMPACT: The widespread use of therapeutic hypothermia (TH) in the treatment of neonatal encephalopathy (NE) has reduced the associated morbidity and mortality. However, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. This review details the pathophysiology of NE along with the evidence for the use of TH and other beneficial neuroprotective strategies used in term infants. We also discuss treatment strategies undergoing evaluation at present as potential adjuvant treatments to TH in NE.

Published
2023

4. Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm

Author

Jobe, Alan H, Caplan, Michael S, Polin, Richard A, Laptook, Abbot R, Hensman, Angelita M, Vieira, Elisa, Little, Emilee, Johnson, Katharine, Alksninis, Barbara, Keszler, Mary Lenore, Knoll, Andrea M, Leach, Theresa M, McGowan, Elisabeth C, Watson, Victoria E, Walsh, Michele C, Fanaroff, Avroy A, Payne, Allison, Wilson-Costello, Deanne E, Newman, Nancy S, Siner, Bonnie S, Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G, Yalcinkaya, Gulgun, Goldberg, Ronald N, Cotten, C Michael, Gustafson, Kathryn E, Goldstein, Ricki F, Ashley, Patricia, Auten, Kathy J, Fisher, Kimberley A, Foy, Katherine A, Freedman, Sharon F, Lohmeyer, Melody B, Malcolm, William F, Wallace, David K, Carlton, David P, Stoll, Barbara J, Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J, Carter, Sheena, Fritz, Sobha, Hale, Ellen C, Hutchinson, Amy K, LaRossa, Maureen Mulligan, Loggins, Yvonne, Bottcher, Diane, Higgins, Rosemary D, Archer, Stephanie Wilson, Poindexter, Brenda B, Sokol, Gregory M, Harmon, Heidi M, Papile, Lu-Ann, Hines, Abbey C, Wilson, Leslie D, Herron, Dianne E, Smiley, Lucy, Granger, Douglas A, Kennedy, Kathleen A, Tyson, Jon E, Duncan, Andrea F, Dempsey, Allison G, John, Janice, Jones, Patrick M, Lillie, M Layne, Siddiki, Saba, Sperry, Daniel K, Blaisdell, Carol J, Das, Abhik, Wallace, Dennis, Gantz, Marie G, O’Donnell Auman, Jeanette, Hammond, Jane A, Newman, Jamie E, Poole, W Kenneth, Van Meurs, Krisa P, Stevenson, David K, Ball, M Bethany, DeAnda, Maria Elena, Goodlin, Gabrielle T, Frantz, Ivan D, Fiascone, John M, Kurfiss, Anne, MacKinnon, Brenda L, Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Phillips, Vivien A, Domanovich, Kristy, Whitley, Sally, Smith, Leigh Ann, Kiser, Carin R, and Finer, Neil N

Subjects
Paediatrics, Biomedical and Clinical Sciences, Basic Behavioral and Social Science, Behavioral and Social Science, Mind and Body, Mental Health, Neurosciences, Clinical Research, Pediatric, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Child, Female, Humans, Infant, Newborn, Executive Function, Hydrocortisone, Hypothalamo-Hypophyseal System, Infant, Extremely Premature, Pituitary-Adrenal System, SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics
Abstract

BackgroundExtremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that an attenuated cortisol awakening response would be associated with developmental and behavioral problems at school age in EPT children.MethodsThis secondary analysis of a sub-cohort of the SUPPORT study included children born between 24 and 27 weeks, evaluated at 6-7 years with a neurodevelopmental battery and cortisol measures. Differences were tested between EPT and a term-born group. Relationships of cortisol awakening response to test scores were analyzed.ResultsCortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-IV and NEPSY-II scores were significantly worse among EPT children only. Conners Parent Rating Scale behavior scores were significantly worse among EPT children. After adjusting for covariates, blunted cortisol awakening responses were found to be associated with poorer scores on memory tests and greater problems with inattention for the EPT group (p

Published
2023

6. Serum ferritin values in neonates <29 weeks’ gestation are highly variable and do not correlate with reticulocyte hemoglobin content

Author

Bahr, Timothy M., Tan, Sylvia, Smith, Emily, Beauman, Sandra S., Schibler, Kurt R., Grisby, Cathy A., Lowe, Jean R., Bell, Edward F., Laptook, Abbot R., Shankaran, Seetha, Carlton, David P., Rau, Carrie, Baserga, Mariana C., Flibotte, John, Zaterka-Baxter, Kristin, Walsh, Michele C., Das, Abhik, Christensen, Robert D., and Ohls, Robin K.

Published
2023
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7. Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Author

Green, Charles E., Tyson, Jon E., Heyne, Roy J., Hintz, Susan R., Vohr, Betty R., Bann, Carla M., Das, Abhik, Bell, Edward F., Debsareea, Sana Boral, Stephens, Emily, Gantz, Marie G., Petrie Huitema, Carolyn M., Johnson, Karen J., Watterberg, Kristi L., Mosquera, Ricardo, Peralta-Carcelen, Myriam, Wilson-Costello, Deanne E., Colaizy, Tarah T., Maitre, Nathalie L., Merhar, Stephanie L., Adams-Chapman, Ira, Fuller, Janell, Hartley-McAndrew, Michelle E., Malcolm, William F., Winter, Sarah, Duncan, Andrea F., Myer, Gary J., Kicklighter, Stephen D., Wyckoff, Myra H., DeMauro, Sara B., Hibbs, Anna Maria, Stoll, Barbara J., Carlo, Waldemar A., Van Meurs, Krisa P., Rysavy, Matthew A., Patel, Ravi M., Sánchez, Pablo J., Laptook, Abbot R., Cotten, C. Michael, D’Angio, Carl T., and Walsh, Michele C.

Published
2023
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12. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial.

Author

Blakely, Martin L, Tyson, Jon E, Lally, Kevin P, Hintz, Susan R, Eggleston, Barry, Stevenson, David K, Besner, Gail E, Das, Abhik, Ohls, Robin K, Truog, William E, Nelin, Leif D, Poindexter, Brenda B, Pedroza, Claudia, Walsh, Michele C, Stoll, Barbara J, Geller, Rachel, Kennedy, Kathleen A, Dimmitt, Reed A, Carlo, Waldemar A, Cotten, C Michael, Laptook, Abbot R, Van Meurs, Krisa P, Calkins, Kara L, Sokol, Gregory M, Sanchez, Pablo J, Wyckoff, Myra H, Patel, Ravi M, Frantz, Ivan D, Shankaran, Seetha, D'Angio, Carl T, Yoder, Bradley A, Bell, Edward F, Watterberg, Kristi L, Martin, Colin A, Harmon, Carroll M, Rice, Henry, Kurkchubasche, Arlet G, Sylvester, Karl, Dunn, James CY, Markel, Troy A, Diesen, Diana L, Bhatia, Amina M, Flake, Alan, Chwals, Walter J, Brown, Rebeccah, Bass, Kathryn D, St Peter, Shawn D, Shanti, Christina M, Pegoli, Walter, Skarda, David, Shilyansky, Joel, Lemon, David G, Mosquera, Ricardo A, Peralta-Carcelen, Myriam, Goldstein, Ricki F, Vohr, Betty R, Purdy, Isabell B, Hines, Abbey C, Maitre, Nathalie L, Heyne, Roy J, DeMauro, Sara B, McGowan, Elisabeth C, Yolton, Kimberly, Kilbride, Howard W, Natarajan, Girija, Yost, Kelley, Winter, Sarah, Colaizy, Tarah T, Laughon, Matthew M, Lakshminrusimha, Satyanarayana, and Higgins, Rosemary D

Subjects
Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Infant Mortality, Rare Diseases, Digestive Diseases, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Clinical Trials and Supportive Activities, Good Health and Well Being, Drainage, Enterocolitis, Necrotizing, Feasibility Studies, Female, Humans, Infant, Extremely Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Intestinal Perforation, Laparotomy, Male, Neurodevelopmental Disorders, Survival Rate, Treatment Outcome, isolated intestinal perforation, neonatal surgery, premature infant, randomized clinical trial, surgical necrotizing enterocolitis, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network, Medical and Health Sciences, Surgery
Abstract

ObjectiveThe aim of this study was to determine which initial surgical treatment results in the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP).Summary background dataThe impact of initial laparotomy versus peritoneal drainage for NEC or IP on the rate of death or NDI in extremely low birth weight infants is unknown.MethodsWe conducted the largest feasible randomized trial in 20 US centers, comparing initial laparotomy versus peritoneal drainage. The primary outcome was a composite of death or NDI at 18 to 22 months corrected age, analyzed using prespecified frequentist and Bayesian approaches.ResultsOf 992 eligible infants, 310 were randomized and 96% had primary outcome assessed. Death or NDI occurred in 69% of infants in the laparotomy group versus 70% with drainage [adjusted relative risk (aRR) 1.0; 95% confidence interval (CI): 0.87-1.14]. A preplanned analysis identified an interaction between preoperative diagnosis and treatment group (P = 0.03). With a preoperative diagnosis of NEC, death or NDI occurred in 69% after laparotomy versus 85% with drainage (aRR 0.81; 95% CI: 0.64-1.04). The Bayesian posterior probability that laparotomy was beneficial (risk difference

Published
2021

13. Outcomes of infants with hypoxic ischemic encephalopathy and persistent pulmonary hypertension of the newborn: results from three NICHD studies

Author

Agarwal, Prashant, Shankaran, Seetha, Laptook, Abbot R, Chowdhury, Dhuly, Lakshminrusimha, Satyan, Bonifacio, Sonia Lomeli, Natarajan, Girija, Chawla, Sanjay, Keszler, Martin, Heyne, Roy J, Ambalavanan, Namasivayam, Walsh, Michele C, Das, Abhik, and Van Meurs, Krisa P

Subjects
Paediatrics, Biomedical and Clinical Sciences, Infant Mortality, Pediatric, Clinical Trials and Supportive Activities, Clinical Research, Brain Disorders, Intellectual and Developmental Disabilities (IDD), Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Humans, Hypertension, Pulmonary, Hypothermia, Induced, Hypoxia-Ischemia, Brain, Infant, Infant, Newborn, National Institute of Child Health and Human Development (U.S.), Persistent Fetal Circulation Syndrome, United States, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network, Clinical Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo determine the association of persistent pulmonary hypertension of the newborn (PPHN) with death or disability among infants with moderate or severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia.MethodsWe compared infants with and without PPHN enrolled in the hypothermia arm from three randomized controlled trials (RCTs): Induced Hypothermia trial, "usual care" arm of Optimizing Cooling trial, and Late Hypothermia trial. Primary outcome was death or disability at 18-22 months adjusted for severity of HIE, center, and RCT.ResultsAmong 280 infants, 67 (24%) were diagnosed with PPHN. Among infants with and without PPHN, death or disability was 47% vs. 29% (adjusted OR: 1.65, 0.86-3.14) and death was 26% vs. 12% (adjusted OR: 2.04, 0.92-4.53), respectively.ConclusionsPPHN in infants with moderate or severe HIE was not associated with a statistically significant increase in primary outcome. These results should be interpreted with caution given the limited sample size.

Published
2021

14. Early-Life Outcomes in Relation to Social Determinants of Health for Children Born Extremely Preterm

Author

Jobe, Alan H., Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Bishop, Carmena, Burke, Robert T., Caskey, Melinda, Hoffman, Laurie, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Lamberson, Vita, Leach, Teresa M., Little, Emilee, McGowan, Elisabeth C., Stephens, Bonnie E., Vieira, Elisa, St. Pierre, Lucille, Ventura, Suzy, Watson, Victoria E., Hibbs, Anna Maria, Walsh, Michele C., Wilson-Costello, Deanne E., Newman, Nancy S., Bhola, Monika, Payne, Allison H., Siner, Bonnie S., Yalcinkaya, Gulgun, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Scott, Allison, Parimi, Prabhu S., Gaetano, Lisa, Poindexter, Brenda B., Schibler, Kurt, Kallapur, Suhas G., Donovan, Edward F., Merhar, Stephanie, Grisby, Cathy, Yolton, Kimberly, Alexander, Barbara, Beiersdorfer, Traci, Bridges, Kate, Cahill, Tanya E., Dudley, Juanita, Fischer, Estelle E., Gratton, Teresa L., Hayes, Devan, Hessling, Jody, Jackson, Lenora D., Kirker, Kristin, Mincey, Holly L., Muthig, Greg, Stacey, Sara, Steichen, Jean J., Tepe, Stacey, Thompson, Julia, Wuertz, Sandra, Cotten, C. Michael, Goldberg, Ronald N., Goldstein, Ricki F., Malcolm, William F., Mago-Shah, Deesha, Ashley, Patricia L., Finkle, Joanne, Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Talbert, Jennifer, Warner, Diane, Trembath, Andrea, O'Shea, T. Michael, Wereszczak, Janice, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, White, Donna, Patel, Ravi M., Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne C., Adams-Chapman, Ira, Blackwelder, Ann, Bottcher, Diane I., Carter, Sheena L., Kendrick-Allwood, Salathiel, Laursen, Judith, LaRossa, Maureen Mulligan, Mackie, Colleen, Sanders, Amy, Seabrook, Irma, Smikle, Gloria, Wineski, Lynn C., Higgins, Rosemary D., Bremer, Andrew A., Archer, Stephanie Wilson, Sokol, Gregory M., Dusick, Anna M., Papile, Lu Ann, Gunn, Susan, Hamer, Faithe, Harmon, Heidi M., Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Miller, Lucy C., Minnich, Heike M., Richard, Leslie, Smiley, Lucy, Wilson, Leslie Dawn, Tyson, Jon E., Kennedy, Kathleen A., Khan, Amir M., Duncan, Andrea, Mosquera, Ricardo, Stephens, Emily K., McDavid, Georgia E., Alaniz, Nora I., Allain, Elizabeth, Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Eason, Elizabeth, Evans, Patricia W., Garcia, Carmen, Green, Charles, Hall, Donna, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Lis, Anna E., Martin, Karen, Martin, Sara C., Mason, Carrie M., McKee, Shannon, Morris, Brenda H., Rennie, Kimberly, Rodgers, Shawna, Siddiki, Saba Khan, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Slaughter, Jonathan L., Yeates, Keith O., Keim, Sarah, Maitre, Nathalie L., Timan, Christopher J., Luzader, Patricia, Clark, Erna, Fortney, Christine A., Gutentag, Julie, Park, Courtney, Shadd, Julie, Sullivan, Margaret, Stein, Melanie, Nelin, Mary Ann, Newton, Julia, Small, Kristi, Burkhardt, Stephanie, Purnell, Jessica, Pietruszewski, Lindsay, Levengood, Katelyn, Batterson, Nancy, Morehead, Pamela, Carey, Helen, Yoseff-Salameh, Lina, Sullivan, Rox Ann, Hague, Cole, Grothause, Jennifer, Fearns, Erin, Fowler, Aubrey, Notestine, Jennifer, Tonneman, Jill, Hay, Krystal, Chao, Michelle, Warnimont, Kyrstin, Marzec, Laura, Miller, Bethany, Beckford, Demi R., Baugher, Hallie, DeSantis, Brittany, Hanlon, Cory, McCool, Jacqueline, Das, Abhik, Gantz, Marie G., Bann, Carla M., Wallace, Dennis, Crawford, Margaret M., Gabrio, Jenna, Leblond, David, Newman, Jamie E., Petrie Huitema, Carolyn M., O'Donnell Auman, Jeanette, Poole, W. Kenneth, Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Chock, Valerie Y., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Bentley, Barbara, Bruno, Elizabeth, Davis, Alexis S., Elena DeAnda, Maria, DeBattista, Anne M., Huffman, Lynne C., Ismael, Magdy, Kohn, Jean G., Krueger, Casey, Lowe, Janice, Lucash, Ryan E., Palmquist, Andrew W., Patel, Jessica, Proud, Melinda S., Reichert, Elizabeth N., John, Nicholas H. St., Sivakumar, Dharshi, Taylor, Heather L., Wager, Natalie, Williams, R. Jordan, Weiss, Hali, Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Church, Paige T., Sibley, Cecelia E., Brussa, Ana K., Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Nelson, Kathleen G., Bailey, Kirstin J., Biasini, Fred J., Chopko, Stephanie A., Collins, Monica V., Cosby, Shirley S., Johnston, Kristen C., Moses, Mary Beth, Patterson, Cryshelle S., Phillips, Vivien A., Preskitt, Julie, Rector, Richard V., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Widness, John A., Brumbaugh, Jane E., Acarregui, Michael J., Johnson, Karen J., Eastman, Diane L., Goeke, Claire A., Schmelzel, Mendi L., Walker, Jacky R., Baack, Michelle L., Hogden, Laurie A., Broadbent, Megan, Elenkiwich, Chelsey, Henning, Megan M., Van Muyden, Sarah, Ellsbury, Dan L., Campbell, Donia B., Tud, Tracy L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Fuller, Janell, Ohls, Robin K., Beauman, Sandra Sundquist, Lacy, Conra Backstrom, Duncan, Andrea F., Hanson, Mary, Hartenberger, Carol, Kuan, Elizabeth, Lowe, Jean R., Thomson, Rebecca A., DeMauro, Sara B., Eichenwald, Eric C., Schmidt, Barbara, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Catts, Christine, Cook, Noah, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Ghavam, Sarvin, Hurt, Hallam, Snyder, Jonathan, Vangala, Saritha, Ziolkowski, Kristina, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Myers, Gary J., Andrews-Hartley, Michelle, Johnson, Julie Babish, Binion, Kyle, Bowman, Melissa, Boylin, Elizabeth, Burnell, Erica, Coleman, Kelly R., Fallone, Cait, Farooq, Osman, Hunn, Julianne, Hust, Diane, Jensen, Rosemary L., Jones, Rachel, Kachelmeyer, Jennifer, Kushner, Emily, Maffett, Deanna, McKee, Kimberly G., Merzbach, Joan, Orme, Constance, Prinzing, Diane, Reubens, Linda J., Rochez, Daisy, Rowan, Mary, Sabaratnam, Premini, Scorsone, Ann Marie, Wadkins, Holly I.M., Yost, Kelley, Zwetsch, Lauren, Lakshminrusimha, Satyan, Reynolds, Anne Marie, Sacilowski, Michael G., Guilford, Stephanie, Li, Emily, Williams, Ashley, Zorn, William A., Wyckoff, Myra H., Brion, Luc P., Salhab, Walid A., Rosenfeld, Charles R., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Francis, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., McDougald, E. Rebecca, Miller, Nancy A., Morgan, Janet S., Pavageau, Lara, Sepulveda, Pollieanna, Tolentino-Plata, Kristine, Boatman, Cathy Twell, Vera, Azucena, Waterbury, Jillian, Yoder, Bradley A., Baserga, Mariana, Faix, Roger G., Winter, Sarah, Minton, Stephen D., Sheffield, Mark J., Rau, Carrie A., Baker, Shawna, Bird, Karie, Burnett, Jill, Christensen, Susan, Cole-Bledsoe, Laura, Davis, Brandy, Elmont, Jennifer O., Jensen, Jennifer J., Loertscher, Manndi C., Jordan, Jamie, Marchant, Trisha, Maxson, Earl, McGrath, Kandace M., Osborne, Karen A., Parry, D. Melody, Reich, Brixen A., Schaefer, Susan T., Spencer, Cynthia, Steffen, Michael, Tice, Katherine, Weaver-Lewis, Kimberlee, Woodbury, Kathryn D., Zanetti, Karen, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Natarajan, Girija, Pappas, Athina, Abramczyk, Katherine, Agarwal, Prashant, Bajaj, Monika, Bara, Rebecca, Billian, Elizabeth, Chawla, Sanjay, Childs, Kirsten, De Jesus, Lilia C., Driscoll, Debra, February, Melissa, Goldston, Laura A., Johnson, Mary E., Muran, Geraldine, Panaitescu, Bogdan, Prentiss, Jeannette E., White, Diane, Woldt, Eunice, Barks, John, Wiggins, Stephanie A., Christensen, Mary K., Carlson, Martha D., Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Vohr, Betty R., Travers, Colm P., and Hintz, Susan R.

Published
2023
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18. Early brain and abdominal oxygenation in extremely low birth weight infants

Author

Chock, Valerie Y., Smith, Emily, Tan, Sylvia, Ball, M. Bethany, Das, Abhik, Hintz, Susan R., Kirpalani, Haresh, Bell, Edward F., Chalak, Lina F., Carlo, Waldemar A., Cotten, C. Michael, Widness, John A., Kennedy, Kathleen A., Ohls, Robin K., Seabrook, Ruth B., Patel, Ravi M., Laptook, Abbot R., Mancini, Toni, Sokol, Gregory M., Walsh, Michele C., Yoder, Bradley A., Poindexter, Brenda B., Chawla, Sanjay, D’Angio, Carl T., Higgins, Rosemary D., and Van Meurs, Krisa P.

Published
2022
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20. Inadequate oral feeding as a barrier to discharge in moderately preterm infants

Author

Edwards, Laura, Cotten, C Michael, Smith, P Brian, Goldberg, Ronald, Saha, Shampa, Das, Abhik, Laptook, Abbot R, Stoll, Barbara J, Bell, Edward F, Carlo, Waldemar A, D’Angio, Carl T, DeMauro, Sara B, Sanchez, Pablo J, Shankaran, Seetha, Van Meurs, Krisa P, Vohr, Betty R, Walsh, Michele C, and Malcolm, William F

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Lung, Infant Mortality, Neonatal Respiratory Distress, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Bottle Feeding, Breast Feeding, Energy Intake, Feeding Behavior, Feeding Methods, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Logistic Models, Male, Patient Discharge, Prospective Studies, Respiratory Distress Syndrome, Newborn, Sepsis, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Clinical Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectivesThe objectives describe the frequency that inadequate oral feeding (IOF) is the reason why moderately preterm (MPT) infants remain hospitalized and its association with neonatal morbidities.Study designProspective study using the NICHD Neonatal Research Network MPT Registry. Multivariable logistic regression was used to describe associations between IOF and continued hospitalization at 36 weeks postmenstrual age (PMA).ResultA total of 6017 MPT infants from 18 centers were included. Three-thousand three-seventy-six (56%) remained hospitalized at 36 weeks PMA, of whom 1262 (37%) remained hospitalized due to IOF. IOF was associated with RDS (OR 2.02, 1.66-2.46), PDA (OR 1.86, 1.37-2.52), sepsis (OR 2.36, 95% 1.48-3.78), NEC (OR 16.14, 7.27-35.90), and BPD (OR 3.65, 2.56-5.21) compared to infants discharged and was associated with medical NEC (OR 2.06, 1.19-3.56) and BPD (OR 0.46, 0.34-0.61) compared to infants remaining hospitalized for an alternative reason.ConclusionIOF is the most common barrier to discharge in MPT infants, especially among those with neonatal morbidities.

Published
2019

21. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial.

Author

Shankaran, Seetha, Bell, Edward F, Laptook, Abbot R, Saha, Shampa, Newman, Nancy S, Kazzi, S Nadya J, Barks, John, Stoll, Barbara J, Bara, Rebecca, Gabrio, Jenna, Childs, Kirsten, Das, Abhik, Higgins, Rosemary D, Carlo, Waldemar A, Sánchez, Pablo J, Carlton, David P, Pavageau, Lara, Malcolm, William F, D'Angio, Carl T, Ohls, Robin K, Poindexter, Brenda B, Sokol, Gregory M, Van Meurs, Krisa P, Colaizy, Tarah T, Khmour, Ayman, Puopolo, Karen M, Garg, Meena, Walsh, Michele C, and Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network

Subjects
Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network, Humans, Body Weight, Length of Stay, Patient Discharge, Incubators, Infant, Infant Equipment, Infant, Newborn, Infant, Premature, Intensive Care Units, Neonatal, Female, Male, incubator, moderately preterm infants, randomized controlled trial, temperature, weaning, Infant Mortality, Perinatal Period - Conditions Originating in Perinatal Period, Patient Safety, Clinical Research, Pediatric, Clinical Trials and Supportive Activities, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Good Health and Well Being, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo assess whether length of hospital stay is decreased among moderately preterm infants weaned from incubator to crib at a lower vs higher weight.Study designThis trial was conducted in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants with gestational ages 29-33 weeks, birthweight

Published
2019

24. Pulmonary Hypertension Associated with Hypoxic-Ischemic Encephalopathy—Antecedent Characteristics and Comorbidities

Author

Lakshminrusimha, Satyan, Shankaran, Seetha, Laptook, Abbot, McDonald, Scott, Keszler, Martin, Van Meurs, Krisa, Guillet, Ronnie, Chawla, Sanjay, Sood, Beena G, Bonifacio, Sonia, Das, Abhik, and Higgins, Rosemary D

Subjects
Hematology, Pediatric, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Brain Disorders, Infectious Diseases, Lung, Cardiovascular, Infant Mortality, Intellectual and Developmental Disabilities (IDD), Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.7 Physical, Reproductive health and childbirth, Good Health and Well Being, Acidosis, Asphyxia Neonatorum, Comorbidity, Data Interpretation, Statistical, Female, Humans, Hypertension, Pulmonary, Hypothermia, Induced, Hypoxia-Ischemia, Brain, Infant, Newborn, Length of Stay, Male, Maternal Age, Meconium Aspiration Syndrome, acidosis, asphyxia, cooling, hypoxia, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

OBJECTIVE:To determine the characteristics of term infants with persistent pulmonary hypertension of the newborn (PPHN) associated with moderate or severe hypoxic ischemic encephalopathy (HIE). METHODS:We compared infants with and without PPHN enrolled in 2 randomized trials of therapeutic hypothermia: the induced hypothermia trial of cooling to 33.5°C for 72 hours vs normothermia, and the "usual-care" arm (33.5°C for 72 hours) of the optimizing cooling trial. RESULTS:Among 303 infants with HIE from these 2 studies, 67 (22%) had PPHN and 236 (78%) did not. We compared infants with PPHN with those without PPHN. The proportion of patients treated with therapeutic hypothermia was similar in PPHN and no-PPHN groups (66% vs 65%). Medication use during resuscitation (58% vs 44%), acidosis after birth (pH: 7.0 ± 0.2 vs 7.1 ± 0.2), severe HIE (43% vs 28%), meconium aspiration syndrome (39% vs 7%), pulmonary hemorrhage (12% vs 3%), culture-positive sepsis (12% vs 3%), systemic hypotension (65% vs 28%), inhaled nitric oxide therapy (64% vs 3%), and extracorporeal membrane oxygenation (12% vs 0%) were more common in the PPHN group. Length of stay (26 ± 21 vs 16 ± 14 days) and mortality (27% vs 16%) were higher in the PPHN group. CONCLUSIONS:PPHN is common among infants with moderate/severe HIE and is associated with severe encephalopathy, lung disease, sepsis, systemic hypotension, and increased mortality. The prevalence of PPHN was not different between those infants receiving therapeutic hypothermia at 33.5°C in these 2 trials (44/197 = 22%) compared with infants receiving normothermia in the induced hypothermia trial (23/106 = 22%).

Published
2018

25. Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants.

Author

Natarajan, Girija, Shankaran, Seetha, Saha, Shampa, Laptook, Abbot, Das, Abhik, Higgins, Rosemary, Stoll, Barbara J, Bell, Edward F, Carlo, Waldemar A, D'Angio, Carl, DeMauro, Sara B, Sanchez, Pablo, Van Meurs, Krisa, Vohr, Betty, Newman, Nancy, Hale, Ellen, Walsh, Michele, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Subjects
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Brain, Humans, Intracranial Hemorrhages, Leukomalacia, Periventricular, Hydrocephalus, Chorioamnionitis, Neonatal Screening, Resuscitation, Cesarean Section, Registries, Logistic Models, Risk Factors, Prospective Studies, Gestational Age, Pregnancy, Adult, Infant, Infant, Newborn, Infant, Small for Gestational Age, Infant, Premature, Female, Young Adult, intracranial hemorrhage, moderate preterm, periventricular leukomalacia, ultrasound, Pediatric, Infant Mortality, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Lung, Reproductive health and childbirth, Good Health and Well Being, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

OBJECTIVES:To describe the frequency and findings of cranial imaging in moderately preterm infants (born at 290/7-336/7 weeks of gestation) across centers, and to examine the association between abnormal imaging and clinical characteristics. STUDY DESIGN:We used data from the Neonatal Research Network Moderately Preterm Registry, including the most severe early (≤28 days) and late (>28 days) cranial imaging. Stepwise logistic regression and CART analysis were performed after adjustment for gestational age, antenatal steroid use, and center. RESULTS:Among 7021 infants, 4184 (60%) underwent cranial imaging. These infants had lower gestational ages and birth weights and higher rates of small for gestational age, outborn birth, cesarean delivery, neonatal resuscitation, and treatment with surfactant, compared with those without imaging (P

Published
2018

26. Umbilical Cord Milking vs Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants

Author

Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Pierre, Lucille St., Hibbs, Anna Maria, Truog, William E., Pallotto, Eugenia K., Parimi, Prabhu S., Gauldin, Cheri, Holmes, Anne, Knutson, Allison, Gaetano, Lisa, Poindexter, Brenda B., Schibler, Kurt, Merhar, Stephanie L., Grisby, Cathy, Kirker, Kristin, Cotten, C. Michael, Goldberg, Ronald N., Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, White, Donna, Carlton, David P., Patel, Ravi M., Loggins, Yvonne, Mackie, Colleen, Bottcher, Diane I., Bremer, Andrew A., Higgins, Rosemary D., Wilson Archer, Stephanie, Sokol, Gregory M., Herron, Dianne E., Tyson, Jon E., Khan, Amir M., Kennedy, Kathleen A., Pedrozza, Claudia, Eason, Elizabeth, Stephens, Emily K., McDavid, Georgia E., Martin, Karen, Hall, Donna, Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Clark, Erna, Gutentag, Julie, Park, Courtney, Shadd, Julie C., Stein, Melanie, Baugher, Hallie, McCool, Jacqueline, Gantz, Marie G., Bann, Carla M., Wallace, Dennis, Zaterka-Baxter, Kristin M., Gabrio, Jenna, Leblond, David, Auman, Jeanette O'Donnell, Stevenson, David K., Chock, Valerie Y., Ball, M. Bethany, Proud, Melinda S., Reichert, Elizabeth N., Williams, R. Jordan, Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., McNair, Tara, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Bell, Edward F., Colaizy, Tarah T., Ellsbury, Dan L., Baack, Michelle L., Johnson, Karen J., Schmelzel, Mendi L., Walker, Jacky R., Goeke, Claire A., Tud, Tracy L., Elenkiwich, Chelsey, Henning, Megan M., Broadbent, Megan, Hogden, Laurie A., Brumbaugh, Jane E., Klein, Jonathan M., Dagle, John M., Fuller, Janell, Ohls, Robin K., Sundquist Beauman, Sandra, Backstrom Lacy, Conra, Hartenberger, Carol, Hanson, Mary, Kuan, Elizabeth, Eichenwald, Eric C., Schmidt, Barbara, Kirpalani, Haresh, Abbasi, Soraya, Catts, Christine, Chaudhary, Aasma S., Ghavam, Sarvin, Mancini, Toni, Snyder, Jonathan, D'Angio, Carl T., Guillet, Ronnie, Reynolds, Anne Marie, Wadkins, Holly I.M., Sacilowski, Michael G., Rowan, Mary, Jensen, Rosemary L., Maffett, Deanna, Prinzing, Diane, Scorsone, Ann Marie, Binion, Kyle, Guilford, Stephanie, Orme, Constance, Sabaratnam, Premini, Daisy Rochez, Li, Emily, Donato, Jennifer, Lakshminrusimha, Satyan, Jones, Rachel, Brion, Luc P., DeLeon, Maria M., Eubanks, Frances, Sepulvida, Pollieanna, Vasil, Diana M., Yoder, Bradley A., Baserga, Mariana, Minton, Stephen D., Sheffield, Mark J., Rau, Carrie A., Burnett, Jill, Davis, Brandy, Christensen, Susan, Loertscher, Manndi C., Marchant, Trisha, Maxson, Earl, McGrath, Kandace, Elmont, Jennifer O., Parry, Melody, Schaefer, Susan T., Weaver-Lewis, Kimberlee, Woodbury, Kathryn D., Shankaran, Seetha, Natarajan, Girija, Chawla, Sanjay, Childs, Kirsten, Panaitescu, Bogdan, Barks, John, White, Diane F., Kumbhat, Neha, Eggleston, Barry, Davis, Alexis S., DeMauro, Sara B., Van Meurs, Krisa P., Foglia, Elizabeth E., Walsh, Michele C., Watterberg, Kristi L., Wyckoff, Myra H., Das, Abhik, and Handley, Sara C.

Published
2021
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28. Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic–Ischemic Encephalopathy in the Late Hypothermia Trial

Author

Caplan, Michael S., Polin, Richard A., Keszler, Martin, Oh, William, Vohr, Betty R., McGowan, Elizabeth C., Alksninis, Barbara, Basso, Kristin, Bliss, Joseph, Bishop, Carmena, Burke, Robert T., Cashore, William, Caskey, Melinda, Gingras, Dan, Guerina, Nicholas, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Leonard, Martha R., Little, Emilee, Stephens, Bonnie E., Vieira, Elisa, Watson, Victoria E., Hibbs, Anna Maria, Wilson-Costello, Deanne E., Newman, Nancy S., Batton, Beau, Bhola, Monika, Di Fiore, Juliann M., Friedman, Harriet G., Siner, Bonnie S., Stork, Eileen K., Yalcinkaya, Gulgun, Zadell, Arlene, Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Yolton, Kimberly, Grisby, Cathy, Gratton, Teresa L., Merhar, Stephanie, Wuertz, Sandra, Cotten, C. Michael, Fisher, Kimberley A., Grimes, Sandra, Finkle, Joanne, Goldstein, Ricki F., Gustafson, Kathryn E., Malcolm, William F., Ashley, Patricia L., Auten, Kathy J., Lohmeyer, Melody B., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Warner, Diane D., Wereszcsak, Janice, Aliaga, Sofia, Carlton, David P., Stoll, Barbara J., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Mackie, Colleen, LaRossa, Maureen Mulligan, Adams-Chapman, Ira, Wineski, Lynn C., Carter, Sheena L., Higgins, Rosemary D., Archer, Stephanie Wilson, Harmon, Heidi M., Papile, Lu-Ann, Dusick, Anna M., Gunn, Susan, Herron, Dianne E., Hines, Abbey C., Kardatzke, Darlene, Lytle, Carolyn, Minnich, Heike M., Richard, Leslie, Smiley, Lucy C., Wilson, Leslie Dawn, Kennedy, Kathleen A., Allain, Elizabeth, Mason, Carrie M., Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Duncan, Andrea F., Evans, Patricia W., Garcia, Carmen, Green, Charles E., Jimenez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Martin, Karen, Martin, Sara C., McDavid, Georgia E., McKee, Shannon, Pierce Tate, Patti L., Rodgers, Shawna, Siddiki, Saba Khan, Sperry, Daniel K., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Grothause, Jennifer L., Wallace, Dennis, Gantz, Marie G., Zaterka-Baxter, Kristin M., Crawford, Margaret M., McDonald, Scott A., Newman, Jamie E., O'Donnell Auman, Jeanette, Petrie Huitema, Carolyn M., Pickett, James W., II, Yost, Patricia, Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Bentley, Barbara, Chock, Valerie Y., Bruno, Elizabeth F., Davis, Alexis S., DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey E., Proud, Melinda S., Rhine, William D., St. John, Nicholas H., Taylor, Heather, Weiss, Hali E., Carlo, Waldemar A., Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Rector, Richard V., Whitley, Sally, Colaizy, Tarah T., Brumbaugh, Jane E., Johnson, Karen J., Eastman, Diane L., Acarregui, Michael J., Walker, Jacky R., Goeke, Claire A., Klein, Jonathan M., Krutzfield, Nancy J., Segar, Jeffrey L., Dagle, John M., Lindower, Julie B., McElroy, Steven J., Rabe, Glenda K., Roghair, Robert D., Meyer, Lauritz R., Ellsbury, Dan L., Campbell, Donia B., Murphy, Cary R., Bhavsar, Vipinchandra, Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandra Sundquist, Brown, Sandra, Fernandez, Erika, Duncan, Andrea Freeman, Fuller, Janell, Kuan, Elizabeth, Lowe, Jean R., Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Dysart, Kevin C., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl, Lakshminrusimha, Satyan, Laroia, Nirupama, Myers, Gary J., Yost, Kelley, Guilford, Stephanie, Jensen, Rosemary L., Wynn, Karen, Farooq, Osman, Reynolds, Anne Marie, Wadkins, Holly I.M., Williams, Ashley, Merzbach, Joan, Conway, Patrick, Bowman, Melissa, Hartley-McAndrew, Michele, Zorn, William, Fallone, Cait, Binion, Kyle, Orme, Constance, Scorsone, Ann Marie, Brion, Luc P., Chalak, Lina F., Heyne, Roy J., Chen, Lijun, Vasil, Diana M., Adams, Sally S., Boatman, Catherine Twell, Guzman, Alicia, Heyne, Elizabeth T., Lee, Lizette E., Leps, Melissa H., Madden, Linda A., Miller, Nancy A., Ramon, Emma, Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Steele, R. Edison, Steffen, Mike, Strong, Karena, Weaver-Lewis, Kimberlee, Baker, Shawna, Winter, Sarah, Bird, Karie, Burnett, Jill, Sood, Beena G., Bara, Rebecca, Childs, Kirsten, De Jesus, Lilia C., Panaitescu, Bogdan, Chawla, Sanjay M.D., Prentice, Jeannette E., Goldston, Laura A., Woldt, Eunice Hinz, Natarajan, Girija, Bajaj, Monika, Barks, John, Christensen, Mary, Wiggins, Stephanie A., Laptook, Abbot R., Shankaran, Seetha, Barnes, Patrick, Rollins, Nancy, Do, Barbara T., Parikh, Nehal A., Hamrick, Shannon, Hintz, Susan R., Tyson, Jon E., Bell, Edward F., Ambalavanan, Namasivayam, Goldberg, Ronald N., Pappas, Athina, Huitema, Carolyn, Pedroza, Claudia, Chaudhary, Aasma S., Hensman, Angelita M., Das, Abhik, Wyckoff, Myra, Khan, Amir, Walsh, Michelle C., Watterberg, Kristi L., Faix, Roger, Truog, William, Guillet, Ronnie, Sokol, Gregory M., and Poindexter, Brenda B.

Published
2021
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29. Advantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial

Author

Pedroza, Claudia, Tyson, Jon E, Das, Abhik, Laptook, Abbot, Bell, Edward F, Shankaran, Seetha, and for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Services and Systems, Clinical Sciences, Health Sciences, Pediatric, Clinical Research, Patient Safety, Clinical Trials and Supportive Activities, Health and social care services research, 8.4 Research design and methodologies (health services), Good Health and Well Being, Age Factors, Bayes Theorem, Body Temperature Regulation, Clinical Protocols, Early Termination of Clinical Trials, Hospital Mortality, Humans, Hypothermia, Induced, Hypoxia-Ischemia, Brain, Infant, Infant Mortality, Infant, Newborn, Medical Futility, Research Design, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, United States, Bayesian methods, Factorial trial, Hypothermia, Phase III trial, Stopping rules, Trial monitoring, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, General & Internal Medicine, Clinical sciences, Health services and systems
Abstract

BackgroundDecisions to stop randomized trials are often based on traditional P value thresholds and are often unconvincing to clinicians. To familiarize clinical investigators with the application and advantages of Bayesian monitoring methods, we illustrate the steps of Bayesian interim analysis using a recent major trial that was stopped based on frequentist analysis of safety and futility.MethodsWe conducted Bayesian reanalysis of a factorial trial in newborn infants with hypoxic-ischemic encephalopathy that was designed to investigate whether outcomes would be improved by deeper (32 °C) or longer cooling (120 h), as compared with those achieved by standard whole body cooling (33.5 °C for 72 h). Using prior trial data, we developed neutral and enthusiastic prior probabilities for the effect on predischarge mortality, defined stopping guidelines for a clinically meaningful effect, and derived posterior probabilities for predischarge mortality.ResultsBayesian relative risk estimates for predischarge mortality were closer to 1.0 than were frequentist estimates. Posterior probabilities suggested increased predischarge mortality (relative risk > 1.0) for the three intervention groups; two crossed the Bayesian futility threshold.ConclusionsBayesian analysis incorporating previous trial results and different pre-existing opinions can help interpret accruing data and facilitate informed stopping decisions that are likely to be meaningful and convincing to clinicians, meta-analysts, and guideline developers.Trial registrationClinicalTrials.gov NCT01192776 . Registered on 31 August 2010.

Published
2016

30. Outcomes Following Post-Hemorrhagic Ventricular Dilatation among Infants of Extremely Low Gestational Age

Author

Shankaran, Seetha, Bajaj, Monika, Natarajan, Girija, Saha, Shampa, Pappas, Athina, Davis, Alexis S., Hintz, Susan R., Adams-Chapman, Ira, Das, Abhik, Bell, Edward F., Stoll, Barbara J., Walsh, Michele C., Laptook, Abbot R., Carlo, Waldemar A., Van Meurs, Krisa P., Sánchez, Pablo J., Ball, M. Bethany, Hale, Ellen C., Seabrook, Ruth, and Higgins, Rosemary D.

Published
2020
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31. Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia

Author

Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Little, Emilee, Burke, Robert T., Stephens, Bonnie E., Alksninis, Barbara, Bishop, Carmena, Keszler, Mary L., Leach, Teresa M., Watson, Victoria E., Knoll, Andrea M., Walsh, Michele C., Fanaroff, Avroy A., Newman, Nancy S., Wilson-Costello, Deanne E., Payne, Allison, Bhola, Monika, Yalcinkaya, Gulgun, Siner, Bonnie S., Friedman, Harriet G., Roth, Elizabeth, Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Poindexter, Brenda B., Merhar, Stephanie, Yolton, Kimberly, Gratton, Teresa L., Grisby, Cathy, Kirker, Kristin, Wuertz, Sandra, Carlton, David P., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne C., Bottcher, Diane I., Mackie, Colleen, Carter, Sheena L., LaRossa, Maureen Mulligan, Wineski, Lynn C., Smikle, Gloria V., Leon-Hernandez, Angela, Kendrick-Allwood, Salathiel, Cotten, C. Michael, Goldberg, Ronald N., Goldstein, Ricki F., Malcolm, William F., Ashley, Patricia L., Finkle, Joanne, Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Warner, Diane, Wereszczak, Janice, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, Higgins, Rosemary D., Wilson Archer, Stephanie, Sokol, Gregory M., Papile, Lu Ann, Hines, Abbey C., Herron, Dianne E., Gunn, Susan, Smiley, Lucy, Kennedy, Kathleen A., Tyson, Jon E., Arldt-McAlister, Julie, Burson, Katrina, Dempsey, Allison G., Evans, Patricia W., Garcia, Carmen, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, M. Layne, Martin, Karen, Martin, Sara C., McDavid, Georgia E., Rodgers, Shawna, Siddiki, Saba Khan, Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Sánchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Wallace, Dennis, Gantz, Marie G., Newman, Jamie E., Auman, Jeanette O'Donnell, Crawford, Margaret, Gabrio, Jenna, Leblond, David, Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Chock, Valerie Y., Stevenson, David K., Adams, Marian M., Ball, M. Bethany, Bentley, Barbara, DeAnda, Maria Elena, Debattista, Anne M., Earhart, Beth, Huffman, Lynne C., Ismael, Magdy, Krueger, Casey E., Palmquist, Andrew W., Proud, Melinda S., Reichert, Elizabeth N., Sankar, Meera N., St. John, Nicholas H., Taylor, Heather L., Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Nylen, Ellen, Furey, Anne, Sibley, Cecelia E., Brussa, Ana K., Carlo, Waldemar A., Ambalavanan, Namasivayam, Bailey, Kirstin J., Biasini, Fred J., Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Rector, Richard V., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, West, Radmila, Baack, Michelle L., Ellsbury, Dan L., Hogden, Laurie A., Klein, Jonathan M., Dagle, John M., Johnson, Karen J., Tud, Tracy L., Elenkiwich, Chelsey, Henning, Megan M., Broadbent, Megan, Schmelzel, Mendi L., Walker, Jacky R., Goeke, Claire A., Watterberg, Kristi L., Ohls, Robin K., Backstrom Lacy, Conra, Brown, Sandra, Fuller, Janell, Hartenberger, Carol, Lowe, Jean R., Sundquist Beauman, Sandra, Hanson, Mary Ruffner, Dupont, Tara, Kuan, Elizabeth, Schmidt, Barbara, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl T., Guillet, Ronnie, Myers, Gary J., Lakshminrusimha, Satyan, Reynolds, Anne Marie, Hartley-McAndrew, Michelle E., Wadkins, Holly I.M., Sacilowski, Michael G., Reubens, Linda J., Jensen, Rosemary L., Merzbach, Joan, Zorn, William, Farooq, Osman, Maffett, Deanna, Williams, Ashley, Hunn, Julianne, Guilford, Stephanie, Yost, Kelley, Rowan, Mary, Prinzing, Diane M., Wynn, Karen, Fallone, Cait, Scorsone, Ann Marie, Wyckoff, Myra H., Brion, Luc P., Heyne, Roy J., Vasil, Diana M., Adams, Sally S., Chen, Lijun, De Leon, Maria M., Eubanks, Frances, Guzman, Alicia, Heyne, Elizabeth T., Madden, Linda A., Miller, Nancy A., Lee, Lizette E., Pavageau, Lara, Sepulveda, Pollieanna, Boatman, Cathy Twell, Faix, Roger G., Yoder, Bradley A., Baserga, Mariana, Osborne, Karen A., Baker, Shawna, Bird, Karie, Burnett, Jill, Christensen, Susan, Davis, Brandy, Elmont, Jennifer O., Jensen, Jennifer J., Loertscher, Manndi C., Marchant, Trisha, Maxson, Earl, Minton, Stephen D., Parry, D. Melody, Rau, Carrie A., Schaefer, Susan T., Sheffield, Mark J., Spencer, Cynthia, Steffen, Mike, Weaver-Lewis, Kimberlee, Winter, Sarah, Woodbury, Kathryn D., Zanetti, Karen, Shankaran, Seetha, Chawla, Sanjay, Sood, Beena G., Pappas, Athina, Natarajan, Girija, Bajaj, Monika, Bara, Rebecca, Johnson, Mary E., Goldston, Laura, Wiggins, Stephanie A., Christensen, Mary K., Carlson, Martha, Barks, John, White, Diane F., Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Romano, Elaine, Brumbaugh, Jane E., Bell, Edward F., Grey, Scott F., DeMauro, Sara B., Vohr, Betty R., Harmon, Heidi M., Bann, Carla M., Rysavy, Matthew A., Logan, J. Wells, Colaizy, Tarah T., Peralta-Carcelen, Myriam A., McGowan, Elisabeth C., Duncan, Andrea F., Stoll, Barbara J., Das, Abhik, and Hintz, Susan R.

Published
2020
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32. Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in the US, 2013–2018

Author

Bell, Edward F., Hintz, Susan R., Hansen, Nellie I., Bann, Carla M., Wyckoff, Myra H., DeMauro, Sara B., Walsh, Michele C., Vohr, Betty R., Stoll, Barbara J., Carlo, Waldemar A., Van Meurs, Krisa P., Rysavy, Matthew A., Patel, Ravi M., Merhar, Stephanie L., Sánchez, Pablo J., Laptook, Abbot R., Hibbs, Anna Maria, Cotten, C. Michael, DʼAngio, Carl T., Winter, Sarah, Fuller, Janell, and Das, Abhik

Published
2022
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33. Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision

Author

Polin, Richard A., Laptook, Abbott R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Basso, Kristin M., Burke, Robert, Caskey, Melinda, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Little, Emilee, McGowan, Elisabeth C., Vieira, Elisa, Watson, Victoria E., Ventura, Suzy, Walsh, Michele C., Fanaroff, Avroy A., Hibbs, Anna Marie, Wilson-Costello, Deanne E., Newman, Nancy S., Payne, Allison H., Siner, Bonnie S., Bhola, Monika, Yalcinkaya, Gulgun, Friedman, Harriet G., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Donovan, Edward F., Grisby, Cathy, Bridges, Kate, Alexander, Barbara, Fischer, Estelle E., Mincey, Holly L., Hessling, Jody, Gratton, Teresa L., Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Steichen, Jean J., Tepe, Stacey, Yolton, Kimberly, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia L., Malcolm, William F., Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Finkle, Joanne, Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Manor, Linda, Warner, Diane, Wereszczak, Janice, Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne, Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Dusick, Anna M., Papile, Lu-Ann, Gunn, Susan, Hamer, Faithe, Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Minnich, Heike M., Smiley, Lucy, Wilson, Leslie Dawn, Sanchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Das, Abhik, Wallace, Dennis, Gantz, Marie G., Poole, W. Kenneth, Newman, Jamie E., O'Donnell Auman, Jeanette, Crawford, Margaret M., Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Hintz, Susan R., Ball, M. Bethany, Davis, Alexis S., Palmquist, Andrew W., Proud, Melinda S., Bentley, Barbara, Bruno, Elizabeth, DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey, Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Biasini, Fred J., Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Phillips, Vivien A., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Acarregui, Michael J., Ellsbury, Dan L., Widness, John A., Johnson, Karen J., Campbell, Donia B., Eastman, Diane L., Walker, Jacky R., Brumbaugh, Jane E., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Lowe, Jean R., Fuller, Janell F., Ohls, Robin K., Lacy, Conra Backstrom, Duncan, Andrea F., Montman, Rebecca, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Lakshminrusimha, Satyan, Johnson, Julie Babish, Reubens, Linda J., Horihan, Cassandra A., Hust, Diane, Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Myers, Gary J., Rowan, Mary, Wadkins, Holly I.M., Bowman, Melissa, Hunn, Julianne, Guilford, Stephanie, Maffett, Deanna, Osman, Farooq, Prinzing, Diane, Reynolds, Anne Marie, Sacilowski, Michael G., Williams, Ashley, Wynn, Karen, Yost, Kelley, Zorn, William, Zwetsch, Lauren, Kennedy, Kathleen A., Tyson, Jon E., McDavid, Georgia E., Alaniz, Nora I., Arldt-McAlister, Julie, Burson, Katrina, Evans, Patricia W., Garcia, Carmen, Green, Charles, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, Layne M., Lis, Anna E., Martin, Karen, Martin, Sara C., Morris, Brenda H., Poundstone, M. Layne, Robichaux, Peggy, Rodgers, Shawna, Siddiki, Saba, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Wyckoff, Myra H., Brion, Luc P., Heyne, Roy J., Salhab, Walid A., Rosenfeld, Charles R., Vasil, Diana M., Chen, Lijun, Guzman, Alicia, Hensley, Gaynelle, Leps, Melissa H., Miller, Nancy A., Morgan, Janet S., Adams, Sally S., Boatman, Catherine Twell, Heyne, Elizabeth T., Madden, Linda A., Torres, Lizette E., Faix, Roger G., Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Weaver-Lewis, Kimberlee, Baker, Shawna, Bird, Karie, Burnett, Jill, Steffen, Michael, Jensen, Jennifer J., Winter, Sarah, Zanetti, Karen, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Pappas, Athina, Barks, John, Bara, Rebecca, Goldston, Laura A., Natarajan, Girija, Christensen, Mary, Wiggins, Stephanie A., White, Diane, Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Laptook, Abbot. R., Lowe, Jean, Chowdhury, Dhuly, Higgins, Rosemary D., and Vohr, Betty R.

Published
2019
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34. Causes and Timing of Death in Extremely Premature Infants from 2000 through 2011

Author

Patel, Ravi M, Kandefer, Sarah, Walsh, Michele C, Bell, Edward F, Carlo, Waldemar A, Laptook, Abbot R, Sánchez, Pablo J, Shankaran, Seetha, Van Meurs, Krisa P, Ball, M Bethany, Hale, Ellen C, Newman, Nancy S, Das, Abhik, Higgins, Rosemary D, and Stoll, Barbara J

Subjects
Rare Diseases, Pediatric, Infant Mortality, Neurosciences, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Cause of Death, Congenital Abnormalities, Enterocolitis, Necrotizing, Gestational Age, Humans, Infant, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Infant, Very Low Birth Weight, Risk Factors, United States, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundUnderstanding the causes and timing of death in extremely premature infants may guide research efforts and inform the counseling of families.MethodsWe analyzed prospectively collected data on 6075 deaths among 22,248 live births, with gestational ages of 22 0/7 to 28 6/7 weeks, among infants born in study hospitals within the National Institute of Child Health and Human Development Neonatal Research Network. We compared overall and cause-specific in-hospital mortality across three periods from 2000 through 2011, with adjustment for baseline differences.ResultsThe number of deaths per 1000 live births was 275 (95% confidence interval [CI], 264 to 285) from 2000 through 2003 and 285 (95% CI, 275 to 295) from 2004 through 2007; the number decreased to 258 (95% CI, 248 to 268) in the 2008-2011 period (P=0.003 for the comparison across three periods). There were fewer pulmonary-related deaths attributed to the respiratory distress syndrome and bronchopulmonary dysplasia in 2008-2011 than in 2000-2003 and 2004-2007 (68 [95% CI, 63 to 74] vs. 83 [95% CI, 77 to 90] and 84 [95% CI, 78 to 90] per 1000 live births, respectively; P=0.002). Similarly, in 2008-2011, as compared with 2000-2003, there were decreases in deaths attributed to immaturity (P=0.05) and deaths complicated by infection (P=0.04) or central nervous system injury (P

Published
2015

35. Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants.

Author

De Jesus, Lilia C, Sood, Beena G, Shankaran, Seetha, Kendrick, Douglas, Das, Abhik, Bell, Edward F, Stoll, Barbara J, Laptook, Abbot R, Walsh, Michele C, Carlo, Waldemar A, Sanchez, Pablo J, Van Meurs, Krisa P, Bara, Rebecca, Hale, Ellen C, Newman, Nancy S, Ball, M Bethany, Higgins, Rosemary D, and Eunice Kennedy Shriver National Institute of Health and Human Development Neonatal Research Network

Subjects
Eunice Kennedy Shriver National Institute of Health and Human Development Neonatal Research Network, Humans, Respiration Disorders, Prenatal Exposure Delayed Effects, Heart Diseases, Infant, Premature, Diseases, Acute Disease, Magnesium Sulfate, Retrospective Studies, Pregnancy, Adult, Infant, Newborn, Infant, Premature, Female, Young Adult, antenatal magnesium, nasal continuous positive airway pressure, neonatal resuscitation, preterm infants, Perinatal Period - Conditions Originating in Perinatal Period, Cardiovascular, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Lung, Clinical Trials and Supportive Activities, Neonatal Respiratory Distress, Infant Mortality, Prevention, Reproductive health and childbirth, Good Health and Well Being, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine
Abstract

ObjectiveAntenatal magnesium (anteMg) is used for various obstetric indications including fetal neuroprotection. Infants exposed to anteMg may be at risk for respiratory depression and delivery room (DR) resuscitation. The study objective was to compare the risk of acute cardiorespiratory events among preterm infants who were and were not exposed to anteMg.Study designThis was a retrospective analysis of prospective data collected in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's Generic Database from April 1, 2011, through March 31, 2012. The primary outcome was DR intubation or respiratory support at birth or on day 1 of life. Secondary outcomes were invasive mechanical ventilation, hypotension treatment, neonatal morbidities, and mortality. Logistic regression analysis evaluated the risk of primary outcome after adjustment for covariates.ResultsWe evaluated 1544 infants

Published
2015

36. Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy: A Randomized Clinical Trial

Author

Shankaran, Seetha, Laptook, Abbot R, Pappas, Athina, McDonald, Scott A, Das, Abhik, Tyson, Jon E, Poindexter, Brenda B, Schibler, Kurt, Bell, Edward F, Heyne, Roy J, Pedroza, Claudia, Bara, Rebecca, Van Meurs, Krisa P, Grisby, Cathy, Huitema, Carolyn M Petrie, Garg, Meena, Ehrenkranz, Richard A, Shepherd, Edward G, Chalak, Lina F, Hamrick, Shannon EG, Khan, Amir M, Reynolds, Anne Marie, Laughon, Matthew M, Truog, William E, Dysart, Kevin C, Carlo, Waldemar A, Walsh, Michele C, Watterberg, Kristi L, and Higgins, Rosemary D

Subjects
Paediatrics, Biomedical and Clinical Sciences, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Trials and Supportive Activities, Pediatric, Infant Mortality, Reproductive health and childbirth, Acidosis, Arrhythmias, Cardiac, Developmental Disabilities, Female, Hemorrhage, Humans, Hypothermia, Induced, Hypoxia-Ischemia, Brain, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Male, Survival Analysis, Temperature, Thrombosis, Time Factors, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceHypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models.ObjectiveTo determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both are superior to cooling at 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy.Design, setting, and participantsA randomized, 2 × 2 factorial design clinical trial performed in 18 US centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network between October 2010 and November 2013.InterventionsNeonates were assigned to 4 hypothermia groups; 33.5°C for 72 hours, 32.0°C for 72 hours, 33.5°C for 120 hours, and 32.0°C for 120 hours.Main outcomes and measuresThe primary outcome of death or disability at 18 to 22 months is ongoing. The independent data and safety monitoring committee paused the trial to evaluate safety (cardiac arrhythmia, persistent acidosis, major vessel thrombosis and bleeding, and death in the neonatal intensive care unit [NICU]) after the first 50 neonates were enrolled, then after every subsequent 25 neonates. The trial was closed for emerging safety profile and futility analysis after the eighth review with 364 neonates enrolled (of 726 planned). This report focuses on safety and NICU deaths by marginal comparisons of 72 hours' vs 120 hours' duration and 33.5°C depth vs 32.0°C depth (predefined secondary outcomes).ResultsThe NICU death rates were 7 of 95 neonates (7%) for the 33.5°C for 72 hours group, 13 of 90 neonates (14%) for the 32.0°C for 72 hours group, 15 of 96 neonates (16%) for the 33.5°C for 120 hours group, and 14 of 83 neonates (17%) for the 32.0°C for 120 hours group. The adjusted risk ratio (RR) for NICU deaths for the 120 hours group vs 72 hours group was 1.37 (95% CI, 0.92-2.04) and for the 32.0°C group vs 33.5°C group was 1.24 (95% CI, 0.69-2.25). Safety outcomes were similar between the 120 hours group vs 72 hours group and the 32.0°C group vs 33.5°C group, except major bleeding occurred among 1% in the 120 hours group vs 3% in the 72 hours group (RR, 0.25 [95% CI, 0.07-0.91]). Futility analysis determined that the probability of detecting a statistically significant benefit for longer cooling, deeper cooling, or both for NICU death was less than 2%.Conclusions and relevanceAmong neonates who were full-term with moderate or severe hypoxic ischemic encephalopathy, longer cooling, deeper cooling, or both compared with hypothermia at 33.5°C for 72 hours did not reduce NICU death. These results have implications for patient care and design of future trials.Trial registrationclinicaltrials.gov Identifier: NCT01192776.

Published
2014

37. Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm

Author

Jobe, Alan H., Caplan, Michael S., Laptook, Abbot R., Vohr, Betty R., Oh, William, Hensman, Angelita M., Alksninis, Barbara, Andrews, Dawn, Angela, Kristen, Barnett, Susan, Cashore, Bill, Caskey, Melinda, Francis, Kim, Gingras, Dan, Johnson, Katharine, Leach, Theresa M., Stephens, Bonnie E., Watson, Victoria E., Walsh, Michele C., Fanaroff, Avroy A., Newman, Nancy S., Wilson-Costello, Deanne E., Siner, Bonnie S., Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G., Yalcinkaya, Gulgun, Bulas, Dorothy, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia, Auten, Kathy J., Fisher, Kimberley A., Foy, Katherine A., Freedman, Sharon F., Gustafson, Kathryn E., Lohmeyer, Melody B., Malcolm, William F., Wallace, David K., Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J., Carter, Sheena, Fritz, Sobha, Hale, Ellen C., Hutchinson, Amy K., LaRossa, Maureen Mulligan, Higgins, Rosemary D., Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Dusick, Anna M., Lemons, James A., Wilson, Leslie D., Hamer, Faithe, Cook, Ann B., Herron, Dianne E., Lytle, Carolyn, Minnich, Heike M., Berberich, Mary Anne, Blaisdell, Carol J., Gail, Dorothy B., Kiley, James P., Das, Abhik, Gantz, Marie G., Newman, Jamie E., Cheng, Helen, Hastings, Betty K., McClure, Elizabeth M., Auman, Jeanette O'Donnell, Huitema, Carolyn Petrie, Poole, W. Kenneth, Pickett, James W., II, Wallace, Dennis, Wrage, Lisa A., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Barnes, Patrick D., Bentley, Barbara, Bruno, Elizabeth F., DeAnda, Maria Elena, DeBattista, Anne M., Kohn, Jean G., Proud, Melinda S., Pyle, Renee P., Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., McGowan, Elisabeth C., Furey, Anne, MacKinnon, Brenda L., Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Bailey, Kirstin J., Biasini, Fred J., Hopkins, Maria, Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Rector, Richard V., Rodriguez, Leslie, Soong, Amanda, Whitley, Sally, York, Sheree, Finer, Neil N., Rasmussen, Maynard R., Wozniak, Paul R., Vaucher, Yvonne E., Rich, Wade, Arnell, Kathy, Barbieri-Welge, Rene, Ben-Tall, Ayala, Bridge, Renee, Demetrio, Clarence, Fuller, Martha G., Ito, Elaine, Lukasik, Meghan, Pontillo, Deborah, Posin, Donna, Runyan, Cheryl, Wilkes, James, Zlotnik, Paul, Bell, Edward F., Widness, John A., Acarregui, Michael J., Klein, Jonathan M., Colaizy, Tarah T., Johnson, Karen J., Eastman, Diane L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Calejo, Maria, Diaz, Alexis N., Frade Eguaras, Silvia M., Garcia, Andrea, Hamlin-Smith, Kasey, Berkowits, Michelle Harwood, Hiriart-Fajardo, Sylvia, Mathews, Elaine O., Pierre, Helina, Riguard, Arielle, Stroerger, Alexandra, Watterberg, Kristi L., Ohls, Robin K., Fuller, Janell, Rohr, Julie, Lacy, Conra Backstrom, Lowe, Jean, Montman, Rebecca, Brown, Sandra, Laroia, Nirupama, Phelps, Dale L., Myers, Gary J., Markowitz, Gary D., Reubens, Linda J., Hust, Diane, Augostino, Lisa, Johnson, Julie Babish, Burnell, Erica, Gelbard, Harris, Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Mink, Jonathan, Torres, Carlos, Wang, David, Yost, Kelley, Sánchez, Pablo J., Rosenfeld, Charles R., Salhab, Walid A., Heyne, Roy J., Adams, Sally S., Allen, James, Grau, Laura, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Hickman, Jackie F., Leps, Melissa H., Madden, Linda A., Martin, Melissa, Miller, Nancy A., Morgan, Janet S., Solis, Araceli, Torres, Lizette E., Boatman, Catherine Twell, Vasil, Diana M., Kennedy, Kathleen A., Tyson, Jon E., Evans, Patricia W., Akpa, Esther G., Alaniz, Nora I., Harris, Beverly Foley, Green, Charles, Jiminez, Margarita, Lis, Anna E., Martin, Sarah, McDavid, Georgia E., Morris, Brenda H., Poundstone, Margaret L., Reddoch, Stacy, Siddiki, Saba, Pierce Tate, Patti L., Wright, Sharon L., Yoder, Bradley A., Faix, Roger G., Baker, Shawna, Bird, Karie, Bullwinkle, Anna E., Burnett, Jill, Cole, Laura, Osborne, Karen A., Spencer, Cynthia, Steele, R. Edison, Steffen, Michael, Weaver-Lewis, Kimberlee, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Peters, Nancy J., Jackson, Barbara G., Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Slovis, Thomas L., Pappas, Athina, Bara, Rebecca, Billian, Elizabeth, Goldston, Laura A., Johnson, Mary, Duncan, Andrea F., Bann, Carla M., Dempsey, Allison, Peralta-Carcelen, Myriam, and Hintz, Susan

Published
2019
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38. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial

Author

Polin, Richard A., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Cotten, C. Michael, Goldberg, Ronald N., Roach, Theresa, Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Kicklighter, Stephen D., Rhodes-Ryan, Ginger, Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Harmon, Heidi, Herron, Dianne E., Wright-Coltart, Shirley I., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Gutentag, Julie, Park, Courtney, Shadd, Julie C., Sullivan, Margaret, Grothause, Jennifer L., Stein, Melanie, Clark, Erna, Sullivan, Rox Ann, Wallace, Dennis, Zaterka-Baxter, Kristin M., Crawford, Margaret, Auman, Jeanette O'Donnell, Stevenson, David K., Herfert, Lou Ann, Ball, M. Bethany, Goodlin, Gabrielle T., Proud, Melinda S., Williams, R. Jordan, Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Chanlaw, Teresa, Geller, Rachel, Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Watterberg, Kristi, Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Kirpalani, Haresh, Eichenwald, Eric C., DeMauro, Sara B., Cook, Noah, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, Lakshminrusimha, Satyan, Guillet, Ronnie, Scorsone, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Wyckoff, Myra, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Pappas, Athina, Panaitescu, Bogdan, Handel, Shelley, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Shankaran, Seetha, Bell, Edward F., Laptook, Abbot R., Saha, Shampa, Newman, Nancy S., Kazzi, S. Nadya J., Barks, John, Stoll, Barbara J., Bara, Rebecca, Gabrio, Jenna, Childs, Kirsten, Das, Abhik, Higgins, Rosemary D., Carlo, Waldemar A., Sánchez, Pablo J., Carlton, David P., Pavageau, Lara, Malcolm, William F., D'Angio, Carl T., Ohls, Robin K., Poindexter, Brenda B., Sokol, Gregory M., Van Meurs, Krisa P., Colaizy, Tarah T., Khmour, Ayman, Puopolo, Karen M., Garg, Meena, and Walsh, Michele C.

Published
2019
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39. Association of Maternal Pre-Pregnancy or First Trimester Body Mass Index with Neurodevelopmental Outcome in Extremely Low Gestational Age Neonates

Author

Chawla, Sanjay, primary, Laptook, Abbot, additional, Smith, Emily, additional, Tan, Sylvia, additional, Natarajan, Girija, additional, Wyckoff, Myra, additional, Greenberg, Rachel, additional, Ambalavanan, Namasivayam, additional, Bell, Edward, additional, Meurs, Krisa Van, additional, Hintz, Susan, additional, and Vohr, Betty, additional

Published
2023
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40. Early-Life Outcomes in Relation to Social Determinants of Health for Children Born Extremely Preterm

Author

Brumbaugh, Jane E., primary, Vohr, Betty R., additional, Bell, Edward F., additional, Bann, Carla M., additional, Travers, Colm P., additional, McGowan, Elisabeth C., additional, Harmon, Heidi M., additional, Carlo, Waldemar A., additional, Duncan, Andrea F., additional, Hintz, Susan R., additional, Jobe, Alan H., additional, Caplan, Michael S., additional, Polin, Richard A., additional, Laptook, Abbot R., additional, Keszler, Martin, additional, Hensman, Angelita M., additional, Alksninis, Barbara, additional, Bishop, Carmena, additional, Burke, Robert T., additional, Caskey, Melinda, additional, Hoffman, Laurie, additional, Johnson, Katharine, additional, Keszler, Mary Lenore, additional, Knoll, Andrea M., additional, Lamberson, Vita, additional, Leach, Teresa M., additional, Little, Emilee, additional, Stephens, Bonnie E., additional, Vieira, Elisa, additional, St. Pierre, Lucille, additional, Ventura, Suzy, additional, Watson, Victoria E., additional, Hibbs, Anna Maria, additional, Walsh, Michele C., additional, Wilson-Costello, Deanne E., additional, Newman, Nancy S., additional, Bhola, Monika, additional, Payne, Allison H., additional, Siner, Bonnie S., additional, Yalcinkaya, Gulgun, additional, Truog, William E., additional, Pallotto, Eugenia K., additional, Kilbride, Howard W., additional, Gauldin, Cheri, additional, Holmes, Anne, additional, Johnson, Kathy, additional, Scott, Allison, additional, Parimi, Prabhu S., additional, Gaetano, Lisa, additional, Poindexter, Brenda B., additional, Schibler, Kurt, additional, Kallapur, Suhas G., additional, Donovan, Edward F., additional, Merhar, Stephanie, additional, Grisby, Cathy, additional, Yolton, Kimberly, additional, Alexander, Barbara, additional, Beiersdorfer, Traci, additional, Bridges, Kate, additional, Cahill, Tanya E., additional, Dudley, Juanita, additional, Fischer, Estelle E., additional, Gratton, Teresa L., additional, Hayes, Devan, additional, Hessling, Jody, additional, Jackson, Lenora D., additional, Kirker, Kristin, additional, Mincey, Holly L., additional, Muthig, Greg, additional, Stacey, Sara, additional, Steichen, Jean J., additional, Tepe, Stacey, additional, Thompson, Julia, additional, Wuertz, Sandra, additional, Cotten, C. Michael, additional, Goldberg, Ronald N., additional, Goldstein, Ricki F., additional, Malcolm, William F., additional, Mago-Shah, Deesha, additional, Ashley, Patricia L., additional, Finkle, Joanne, additional, Auten, Kathy J., additional, Fisher, Kimberley A., additional, Grimes, Sandra, additional, Gustafson, Kathryn E., additional, Lohmeyer, Melody B., additional, Laughon, Matthew M., additional, Bose, Carl L., additional, Bernhardt, Janice, additional, Bose, Gennie, additional, Clark, Cindy, additional, Talbert, Jennifer, additional, Warner, Diane, additional, Trembath, Andrea, additional, O'Shea, T. Michael, additional, Wereszczak, Janice, additional, Kicklighter, Stephen D., additional, Rhodes-Ryan, Ginger, additional, White, Donna, additional, Patel, Ravi M., additional, Carlton, David P., additional, Stoll, Barbara J., additional, Hale, Ellen C., additional, Loggins, Yvonne C., additional, Adams-Chapman, Ira, additional, Blackwelder, Ann, additional, Bottcher, Diane I., additional, Carter, Sheena L., additional, Kendrick-Allwood, Salathiel, additional, Laursen, Judith, additional, LaRossa, Maureen Mulligan, additional, Mackie, Colleen, additional, Sanders, Amy, additional, Seabrook, Irma, additional, Smikle, Gloria, additional, Wineski, Lynn C., additional, Higgins, Rosemary D., additional, Bremer, Andrew A., additional, Archer, Stephanie Wilson, additional, Sokol, Gregory M., additional, Dusick, Anna M., additional, Papile, Lu Ann, additional, Gunn, Susan, additional, Hamer, Faithe, additional, Herron, Dianne E., additional, Hines, Abbey C., additional, Lytle, Carolyn, additional, Miller, Lucy C., additional, Minnich, Heike M., additional, Richard, Leslie, additional, Smiley, Lucy, additional, Wilson, Leslie Dawn, additional, Tyson, Jon E., additional, Kennedy, Kathleen A., additional, Khan, Amir M., additional, Duncan, Andrea, additional, Mosquera, Ricardo, additional, Stephens, Emily K., additional, McDavid, Georgia E., additional, Alaniz, Nora I., additional, Allain, Elizabeth, additional, Arldt-McAlister, Julie, additional, Burson, Katrina, additional, Dempsey, Allison G., additional, Eason, Elizabeth, additional, Evans, Patricia W., additional, Garcia, Carmen, additional, Green, Charles, additional, Hall, Donna, additional, Harris, Beverly Foley, additional, Jiminez, Margarita, additional, John, Janice, additional, Jones, Patrick M., additional, Lillie, M. Layne, additional, Lis, Anna E., additional, Martin, Karen, additional, Martin, Sara C., additional, Mason, Carrie M., additional, McKee, Shannon, additional, Morris, Brenda H., additional, Rennie, Kimberly, additional, Rodgers, Shawna, additional, Siddiki, Saba Khan, additional, Simmons, Maegan C., additional, Sperry, Daniel, additional, Pierce Tate, Patti L., additional, Wright, Sharon L., additional, Sánchez, Pablo J., additional, Nelin, Leif D., additional, Jadcherla, Sudarshan R., additional, Slaughter, Jonathan L., additional, Yeates, Keith O., additional, Keim, Sarah, additional, Maitre, Nathalie L., additional, Timan, Christopher J., additional, Luzader, Patricia, additional, Clark, Erna, additional, Fortney, Christine A., additional, Gutentag, Julie, additional, Park, Courtney, additional, Shadd, Julie, additional, Sullivan, Margaret, additional, Stein, Melanie, additional, Nelin, Mary Ann, additional, Newton, Julia, additional, Small, Kristi, additional, Burkhardt, Stephanie, additional, Purnell, Jessica, additional, Pietruszewski, Lindsay, additional, Levengood, Katelyn, additional, Batterson, Nancy, additional, Morehead, Pamela, additional, Carey, Helen, additional, Yoseff-Salameh, Lina, additional, Sullivan, Rox Ann, additional, Hague, Cole, additional, Grothause, Jennifer, additional, Fearns, Erin, additional, Fowler, Aubrey, additional, Notestine, Jennifer, additional, Tonneman, Jill, additional, Hay, Krystal, additional, Chao, Michelle, additional, Warnimont, Kyrstin, additional, Marzec, Laura, additional, Miller, Bethany, additional, Beckford, Demi R., additional, Baugher, Hallie, additional, DeSantis, Brittany, additional, Hanlon, Cory, additional, McCool, Jacqueline, additional, Das, Abhik, additional, Gantz, Marie G., additional, Wallace, Dennis, additional, Crawford, Margaret M., additional, Gabrio, Jenna, additional, Leblond, David, additional, Newman, Jamie E., additional, Petrie Huitema, Carolyn M., additional, O'Donnell Auman, Jeanette, additional, Poole, W. Kenneth, additional, Zaterka-Baxter, Kristin M., additional, Van Meurs, Krisa P., additional, Chock, Valerie Y., additional, Stevenson, David K., additional, Adams, Marian M., additional, Ball, M. Bethany, additional, Bentley, Barbara, additional, Bruno, Elizabeth, additional, Davis, Alexis S., additional, Elena DeAnda, Maria, additional, DeBattista, Anne M., additional, Huffman, Lynne C., additional, Ismael, Magdy, additional, Kohn, Jean G., additional, Krueger, Casey, additional, Lowe, Janice, additional, Lucash, Ryan E., additional, Palmquist, Andrew W., additional, Patel, Jessica, additional, Proud, Melinda S., additional, Reichert, Elizabeth N., additional, John, Nicholas H. St., additional, Sivakumar, Dharshi, additional, Taylor, Heather L., additional, Wager, Natalie, additional, Williams, R. Jordan, additional, Weiss, Hali, additional, Frantz, Ivan D., additional, Fiascone, John M., additional, MacKinnon, Brenda L., additional, Furey, Anne, additional, Nylen, Ellen, additional, Church, Paige T., additional, Sibley, Cecelia E., additional, Brussa, Ana K., additional, Ambalavanan, Namasivayam, additional, Peralta-Carcelen, Myriam, additional, Nelson, Kathleen G., additional, Bailey, Kirstin J., additional, Biasini, Fred J., additional, Chopko, Stephanie A., additional, Collins, Monica V., additional, Cosby, Shirley S., additional, Johnston, Kristen C., additional, Moses, Mary Beth, additional, Patterson, Cryshelle S., additional, Phillips, Vivien A., additional, Preskitt, Julie, additional, Rector, Richard V., additional, Whitley, Sally, additional, Devaskar, Uday, additional, Garg, Meena, additional, Purdy, Isabell B., additional, Chanlaw, Teresa, additional, Geller, Rachel, additional, Finer, Neil N., additional, Vaucher, Yvonne E., additional, Kaegi, David, additional, Rasmussen, Maynard R., additional, Arnell, Kathy, additional, Demetrio, Clarence, additional, Fuller, Martha G., additional, Rich, Wade, additional, Colaizy, Tarah T., additional, Widness, John A., additional, Brumbaugh, Jane E., additional, Acarregui, Michael J., additional, Johnson, Karen J., additional, Eastman, Diane L., additional, Goeke, Claire A., additional, Schmelzel, Mendi L., additional, Walker, Jacky R., additional, Baack, Michelle L., additional, Hogden, Laurie A., additional, Broadbent, Megan, additional, Elenkiwich, Chelsey, additional, Henning, Megan M., additional, Van Muyden, Sarah, additional, Ellsbury, Dan L., additional, Campbell, Donia B., additional, Tud, Tracy L., additional, Duara, Shahnaz, additional, Bauer, Charles R., additional, Everett-Thomas, Ruth, additional, Fajardo-Hiriart, Sylvia, additional, Rigaud, Arielle, additional, Calejo, Maria, additional, Frade Eguaras, Silvia M., additional, Berkowits, Michelle Harwood, additional, Garcia, Andrea, additional, Pierre, Helina, additional, Stoerger, Alexandra, additional, Watterberg, Kristi L., additional, Fuller, Janell, additional, Ohls, Robin K., additional, Beauman, Sandra Sundquist, additional, Lacy, Conra Backstrom, additional, Hanson, Mary, additional, Hartenberger, Carol, additional, Kuan, Elizabeth, additional, Lowe, Jean R., additional, Thomson, Rebecca A., additional, DeMauro, Sara B., additional, Eichenwald, Eric C., additional, Schmidt, Barbara, additional, Kirpalani, Haresh, additional, Chaudhary, Aasma S., additional, Abbasi, Soraya, additional, Mancini, Toni, additional, Catts, Christine, additional, Cook, Noah, additional, Cucinotta, Dara M., additional, Bernbaum, Judy C., additional, Gerdes, Marsha, additional, Ghavam, Sarvin, additional, Hurt, Hallam, additional, Snyder, Jonathan, additional, Vangala, Saritha, additional, Ziolkowski, Kristina, additional, D'Angio, Carl T., additional, Phelps, Dale L., additional, Guillet, Ronnie, additional, Myers, Gary J., additional, Andrews-Hartley, Michelle, additional, Johnson, Julie Babish, additional, Binion, Kyle, additional, Bowman, Melissa, additional, Boylin, Elizabeth, additional, Burnell, Erica, additional, Coleman, Kelly R., additional, Fallone, Cait, additional, Farooq, Osman, additional, Hunn, Julianne, additional, Hust, Diane, additional, Jensen, Rosemary L., additional, Jones, Rachel, additional, Kachelmeyer, Jennifer, additional, Kushner, Emily, additional, Maffett, Deanna, additional, McKee, Kimberly G., additional, Merzbach, Joan, additional, Orme, Constance, additional, Prinzing, Diane, additional, Reubens, Linda J., additional, Rochez, Daisy, additional, Rowan, Mary, additional, Sabaratnam, Premini, additional, Scorsone, Ann Marie, additional, Wadkins, Holly I.M., additional, Yost, Kelley, additional, Zwetsch, Lauren, additional, Lakshminrusimha, Satyan, additional, Reynolds, Anne Marie, additional, Sacilowski, Michael G., additional, Guilford, Stephanie, additional, Li, Emily, additional, Williams, Ashley, additional, Zorn, William A., additional, Wyckoff, Myra H., additional, Brion, Luc P., additional, Salhab, Walid A., additional, Rosenfeld, Charles R., additional, Heyne, Roy J., additional, Vasil, Diana M., additional, Adams, Sally S., additional, Chen, Lijun, additional, De Leon, Maria M., additional, Eubanks, Francis, additional, Guzman, Alicia, additional, Hensley, Gaynelle, additional, Heyne, Elizabeth T., additional, Lee, Lizette E., additional, Leps, Melissa H., additional, Madden, Linda A., additional, McDougald, E. Rebecca, additional, Miller, Nancy A., additional, Morgan, Janet S., additional, Pavageau, Lara, additional, Sepulveda, Pollieanna, additional, Tolentino-Plata, Kristine, additional, Boatman, Cathy Twell, additional, Vera, Azucena, additional, Waterbury, Jillian, additional, Yoder, Bradley A., additional, Baserga, Mariana, additional, Faix, Roger G., additional, Winter, Sarah, additional, Minton, Stephen D., additional, Sheffield, Mark J., additional, Rau, Carrie A., additional, Baker, Shawna, additional, Bird, Karie, additional, Burnett, Jill, additional, Christensen, Susan, additional, Cole-Bledsoe, Laura, additional, Davis, Brandy, additional, Elmont, Jennifer O., additional, Jensen, Jennifer J., additional, Loertscher, Manndi C., additional, Jordan, Jamie, additional, Marchant, Trisha, additional, Maxson, Earl, additional, McGrath, Kandace M., additional, Osborne, Karen A., additional, Parry, D. Melody, additional, Reich, Brixen A., additional, Schaefer, Susan T., additional, Spencer, Cynthia, additional, Steffen, Michael, additional, Tice, Katherine, additional, Weaver-Lewis, Kimberlee, additional, Woodbury, Kathryn D., additional, Zanetti, Karen, additional, Dillard, Robert G., additional, Washburn, Lisa K., additional, Jackson, Barbara G., additional, Peters, Nancy, additional, Chiu, Korinne, additional, Allred, Deborah Evans, additional, Goldstein, Donald J., additional, Halfond, Raquel, additional, Peterson, Carroll, additional, Waldrep, Ellen L., additional, Welch, Cherrie D., additional, Morris, Melissa Whalen, additional, Hounshell, Gail Wiley, additional, Shankaran, Seetha, additional, Sood, Beena G., additional, Natarajan, Girija, additional, Pappas, Athina, additional, Abramczyk, Katherine, additional, Agarwal, Prashant, additional, Bajaj, Monika, additional, Bara, Rebecca, additional, Billian, Elizabeth, additional, Chawla, Sanjay, additional, Childs, Kirsten, additional, De Jesus, Lilia C., additional, Driscoll, Debra, additional, February, Melissa, additional, Goldston, Laura A., additional, Johnson, Mary E., additional, Muran, Geraldine, additional, Panaitescu, Bogdan, additional, Prentiss, Jeannette E., additional, White, Diane, additional, Woldt, Eunice, additional, Barks, John, additional, Wiggins, Stephanie A., additional, Christensen, Mary K., additional, Carlson, Martha D., additional, Ehrenkranz, Richard A., additional, Jacobs, Harris, additional, Butler, Christine G., additional, Cervone, Patricia, additional, Greisman, Sheila, additional, Konstantino, Monica, additional, Poulsen, JoAnn, additional, Taft, Janet, additional, Williams, Joanne, additional, and Romano, Elaine, additional

Published
2023
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42. Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort

Author

Jobe, Alan H., Caplan, Michael S., Polin, Richard A., Laptook, Abbot R., Hensman, Angelita M., McGowan, Elisabeth C., Vieira, Elisa, Little, Emilee, Johnson, Katharine, Alksninis, Barbara, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Watson, Victoria E., Walsh, Michele C., Fanaroff, Avroy A., Wilson-Costello, Deanne E., Payne, Allison, Newman, Nancy S., Taylor, H. Gerry, Siner, Bonnie S., Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G., Yalcinkaya, Gulgun, Bulas, Dorothy, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Gustafson, Kathryn E., Ashley, Patricia, Auten, Kathy J., Fisher, Kimberley A., Foy, Katherine A., Freedman, Sharon F., Lohmeyer, Melody B., Malcolm, William F., Wallace, David K., Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J., Carter, Fritz, Sobha, Hale, Ellen C., Hutchinson, Amy K., LaRossa, Maureen Mulligan, Loggins, Yvonne, Bottcher, Diane, Archer, Stephanie Wilson, Poindexter, Brenda B., Sokol, Gregory M., Harmon, Heidi M., Papile, Lu-Ann, Hines, Abbey C., Wilson, Leslie D., Herron, Dianne E., Smiley, Lucy, Kennedy, Kathleen A., Tyson, Jon E., Duncan, Andrea Freeman, Dempsey, Allison G., John, Janice, Jones, Patrick M., Lillie, M. Layne, Siddiki, Saba, Sperry, Daniel K., Berberich, Mary Anne, Blaisdell, Carol J., Gail, Dorothy B., Kiley, James P., Wallace, Dennis, Gantz, Marie G., Newman, Jamie E., Auman, Jeanette O'Donnell, Hammond, Jane A., Poole, W. Kenneth, Van Meurs, Krisa P., Stevenson, David K., DeAnda, Maria Elena, Ball, M. Bethany, Goodlin, Gabrielle T., Frantz, Ivan D., III, Fiascone, John M., Furey, Anne, MacKinnon, Brenda L., Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Bailey, Kirstin J., Biasini, Fred J., Hopkins, Maria, Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Rector, Richard V., Rodriguez, Leslie, Soong, Amanda, Whitley, Sally, York, Sheree, Guest, Kristy, Smith, Leigh Ann, Finer, Neil N., Garey, Donna, Rasmussen, Maynard R., Wozniak, Paul R., Vaucher, Yvonne E., Fuller, Martha G., Akshoomoff, Natacha, Rich, Wade, Arnell, Kathy, Bridge, Renee, Bell, Edward F., Colaizy, Tarah T., Widness, John A., Klein, Jonathan M., Johnson, Karen J., Acarregui, Michael J., Eastman, Diane L., Wilgenbusch, Tammy L.V., Watterberg, Kristi L., Ohls, Robin K., Fuller, Janell, Lowe, Jean, Rohr, Julie, Lacy, Conra Backstrom, Montman, Rebecca, Brown, Sandra, Sánchez, Pablo J., Rosenfeld, Charles R., Salhab, Walid A., Brion, Luc, Adams, Sally S., Allen, James, Grau, Laura, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Hickman, Jackie F., Leps, Melissa H., Madden, Linda A., Martin, Melissa, Miller, Nancy A., Morgan, Janet S., Solis, Araceli, Lee, Lizette E., Boatman, Catherine Twell, Vasil, Diana M., Yoder, Bradley A., Faix, Roger G., Winter, Sarah, Baker, Shawna, Osborne, Karen A., Rau, Carrie A., Cunningham, Sean, Ford, Ariel, Shankaran, Seetha, Pappas, Athina, Sood, Beena G., Bara, Rebecca, Slovis, Thomas L., Billian, Elizabeth, Goldston, Laura A., Johnson, Mary, Vohr, Betty R., Heyne, Roy, Bann, Carla M., Das, Abhik, Higgins, Rosemary D., and Hintz, Susan R.

Published
2018
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43. Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age

Author

Jobe, Alan H., Caplan, Michael S., Polin, Richard A., Keszler, Martin, Oh, William, Vohr, Betty R., Hensman, Angelita M., Alksninis, Barbara, Basso, Kristin M., Burke, Robert, Caskey, Melinda, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Little, Emilee, McGowan, Elisabeth C., Vieira, Elisa, Watson, Victoria E., Ventura, Suzy, Walsh, Michele C., Fanaroff, Avroy A., Hibbs, Anna Marie, Wilson-Costello, Deanne E., Newman, Nancy S., Payne, Allison H., Siner, Bonnie S., Bhola, Monika, Yalcinkaya, Gulgun, Friedman, Harriet G., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Donovan, Edward F., Grisby, Cathy, Bridges, Kate, Alexander, Barbara, Fischer, Estelle E., Mincey, Holly L., Hessling, Jody, Gratton, Teresa L., Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Steichen, Jean J., Tepe, Stacey, Mersmann, Marcia Worley, Yolton, Kimberly, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia L., Malcolm, William F., Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Finkle, Joanne, Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Warner, Diane, Wereszczak, Janice, Carlton, David P., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne, Blackwelder, Ann M., Bottcher, Diane I., Mackie, Colleen, Higgins, Rosemary D., Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Lemons, James A., Dusick, Anna M., Papile, Lu-Ann, Lytle, Carolyn, Hines, Abbey C., Minnich, Heike M., Herron, Dianne E., Smiley, Lucy, Gunn, Susan, Wilson, Leslie Dawn, Kennedy, Kathleen A., Tyson, Jon E., McDavid, Georgia E., Akpa, Esther G., Arldt-McAlister, Julie, Alaniz, Nora I., Burson, Katrina, Bradt, Pamela J., Dieterich, Susan, Dempsey, Allison, Duncan, Andrea F., Evans, Patricia W., Franco, Claudia I., Garcia, Carmen, Green, Charles, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, Layne M., Lis, Anna E., Major-Kincade, Terri, Martin, Karen, Martin, Sara C., Morris, Brenda H., Orekoya, Patricia Ann, Reddoch, Stacey, Rodgers, Shawna, Siddiki, Saba, Simmons, Maegan C., Sperry, Daniel, Tate, Patti L. Pierce, Whitely, Laura L., Wright, Sharon L., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Wallace, Dennis, Gantz, Marie G., Poole, W. Kenneth, Crawford, Margaret M., Gabrio, Jenna, Hastings, Betty K., Newman, Jamie E., O'Donnell Auman, Jeanette, Huitema, Carolyn M. Petrie, Zaterka-Baxter, Kristin M., Stevenson, David K., Ball, M. Bethany, Adams, Marian M., Davis, Alexis S., Palmquist, Andrew W., Proud, Melinda S., Bentley, Barbara, Bruno, Elizabeth, DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey, Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Biasini, Fred J., Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Phillips, Vivien A., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Kaegi, David, Rasmussen, Maynard R., Wozniak, Paul R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Henderson, Chris, Rich, Wade, Vaucher, Yvonne E., Colaizy, Tarah T., Acarregui, Michael J., Brumbaugh, Jane E., Ellsbury, Dan L., Widness, John A., Johnson, Karen J., Campbell, Donia B., Eastman, Diane L., Krutzfield, Nancy J., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Eguaras, Silvia M. Frade, Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Lowe, Jean R., Dupont, Tara, Fuller, Janell F., Ohls, Robin K., Lacy, Conra Backstrom, Montman, Rebecca, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, Cook, Noah, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Lakshminrusimha, Satyan, Johnson, Julie Babish, Burnell, Erica, Reubens, Linda J., Horihan, Cassandra A., Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Myers, Gary J., Rowan, Mary, Wadkins, Holly I.M., Scorsone, Anne Marie, Bowman, Melissa, Hunn, Julianne, Guilford, Stephanie, Maffett, Deanna, Farooq, Osman, Prinzing, Diane, Reynolds, Anne Marie, Sacilowski, Michael G., Williams, Ashley, Wynn, Karen, Yost, Kelley, Zorn, William, Zwetsch, Lauren, Brion, Luc P., Broyles, R. Sue, Heyne, Roy J., Ipson, Merle, Salhab, Walid A., Rosenfeld, Charles R., Vasil, Diana M., Chen, Lijun, Guzman, Alicia, Hensley, Gaynelle, Hickman, Jackie F., Leps, Melissa H., Madison, Susie, Miller, Nancy A., Morgan, Janet S., Pavageau, Lara, Adams, Sally S., Dooley, Cristin, Heyne, Elizabeth T., Lee, Lizette E., Madden, Linda A., Boatman, Catherine Twell, Faix, Roger G., Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Weaver-Lewis, Kimberlee, Baker, Shawna, Bird, Karie, Burnett, Jill, Steffen, Michael, Jensen, Jennifer J., Winter, Sarah, Zanetti, Karen, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy J., Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Pappas, Athina, Bara, Rebecca, Goldston, Laura A., Muran, Geraldine, Natarajan, Girija, Christensen, Mary, Wiggins, Stephanie A., White, Diane, Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Gettner, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Romano, Elaine, Taft, Janet, Williams, Joanne, Sarkar, Subrata, Shankaran, Seetha, Barks, John, Do, Barbara T., Laptook, Abbot R., Das, Abhik, Ambalavanan, Namasivayam, Van Meurs, Krisa P., Bell, Edward F., Sanchez, Pablo J., Hintz, Susan R., Wyckoff, Myra H., Stoll, Barbara J., and Carlo, Waldemar A.

Published
2018
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44. Delivery Room Resuscitation and Short-Term Outcomes in Moderately Preterm Infants

Author

Polin, Richard A., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Poindexter, Brenda B., Schibler, Kurt, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Cotten, C. Michael, Goldberg, Ronald N., Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Carlton, David P., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Sokol, Greg, Herron, Dianne E., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Parikh, Nehal A., Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E., McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A., Wolfe, Tara, Wallace, Dennis, Zaterka-Baxter, Kristin M., Crawford, Margaret, Gabrio, Jenna, Kandefer, Sarah, O'Donnell Auman, Jeanette, Stevenson, David K., Ball, M. Bethany, Proud, Melinda S., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T., Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Watterberg, Kristi L., Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Cook, Noah, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, Lakshminrusimha, Satyan, Guillet, Ronnie, Scorsone, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Kennedy, Kathleen A., Tyson, Jon E., Arldt-McAlister, Julie, Garcia, Carmen, Martin, Karen, McDavid, Georgia E., Wright, Sharon L., Pappas, Athina, Barks, John, Bara, Rebecca, Handel, Shelley, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Bajaj, Monika, Natarajan, Girija, Shankaran, Seetha, Wyckoff, Myra, Laptook, Abbot R., Bell, Edward F., Stoll, Barbara J., Carlo, Waldemar A., Vohr, Betty R., Saha, Shampa, Van Meurs, Krisa P., Sanchez, Pablo J., D'Angio, Carl T., Higgins, Rosemary D., Das, Abhik, Newman, Nancy, and Walsh, Michele C.

Published
2018
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45. Antecedents and Outcomes of Abnormal Cranial Imaging in Moderately Preterm Infants

Author

Polin, Richard A., Keszler, Martin, Hensman, Angelita M., Vieira, Elisa, Hibbs, Anna Marie, Siner, Bonnie S., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Goldberg, Ronald N., Finkle, Joanne, Fisher, Kimberley A., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Carlton, David P., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Sokol, Greg, Herron, Dianne E., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Parikh, Nehal A., Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E., McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A., Wolfe, Tara, Wallace, Dennis, Zaterka-Baxter, Kristin M., Crawford, Margaret, Gabrio, Jenna, O'Donnell Auman, Jeanette, Stevenson, David K., Ball, M. Bethany, Proud, Melinda S., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T., Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandy Sundquist, Hartenberger, Carol, Kirpalani, Haresh, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, Lakshminrusimha, Satyan, Scorsone, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Wyckoff, Myra, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Tyson, Jon E., Arldt-McAlister, Julie, Garcia, Carmen, Martin, Karen, McDavid, Georgia E., Wright, Sharon L., Pappas, Athina, Barks, John, Bara, Rebecca, Handel, Shelley, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Natarajan, Girija, Shankaran, Seetha, Saha, Shampa, Laptook, Abbot, Das, Abhik, Higgins, Rosemary, Stoll, Barbara J., Bell, Edward F., Carlo, Waldemar A., D'Angio, Carl, DeMauro, Sara B., Sanchez, Pablo, Van Meurs, Krisa, Vohr, Betty, Newman, Nancy, Hale, Ellen, and Walsh, Michele

Published
2018
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46. Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

Author

Polin, Richard A., Keszler, Martin, Vohr, Betty R., Hensman, Angelita M., Vieira, Elisa, Little, Emilee, Fanaroff, Avroy A., Hibbs, Anna Marie, Newman, Nancy S., Siner, Bonnie S., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G., Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Donovan, Edward F., Hessling, Jody, Mersmann, Marcia Worley, Mincey, Holly L., Cotten, C. Michael, Goldberg, Ronald N., Finkle, Joanne, Fisher, Kimberley A., Auten, Kathy J., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Clark, Cindy, Stoll, Barbara J., Carlton, David P., Hale, Ellen C., Loggins, Yvonne, Bottcher, Diane I., Archer, Stephanie Wilson, Wright, Linda L., McClure, Elizabeth M., Poindexter, Brenda B., Sokol, Gregory M., Herron, Dianne E., Lemons, James A., Appel, Diana D., Miller, Lucy C., Sanchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Parikh, Nehal A., Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E., McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A., Wolfe, Tara, Das, Abhik, Wallace, Dennis, Poole, W. Kenneth, Zaterka-Baxter, Kristin M., Crawford, Margaret, Gabrio, Jenna, O'Donnell Auman, Jeanette, Huitema, Carolyn Petrie, Hastings, Betty K., Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Proud, Melinda S., Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T., Ellsbury, Dan L., Brumbaugh, Jane E., Johnson, Karen J., Campbell, Donia B., Walker, Jacky R., Watterberg, Kristi L., Ohls, Robin K., Lacy, Conra Backstrom, Beauman, Sandra Sundquist, Hartenberger, Carol, Schmidt, Barbara, Kirpalani, Haresh, Cook, Noah, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara, D'Angio, Carl T., Guillet, Ronnie, Lakshminrusimha, Satyan, Phelps, Dale L., Reynolds, Ann Marie, Hunn, Julianne, Jensen, Rosemary, Wadkins, Holly I.M., Guilford, Stephanie, Williams, Ashley, Sacilowski, Michael, Reubens, Linda, Burnell, Erica, Rowan, Mary, Wynn, Karen, Maffett, Deanna, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Torres, Lizette E., Salhab, Walid A., Madison, Susie, Hensley, Gay, Miller, Nancy A., Guzman, Alicia, Kennedy, Kathleen A., Tyson, Jon E., Arldt-McAlister, Julie, Garcia, Carmen, Martin, Karen, McDavid, Georgia E., Wright, Sharon L., Akpa, Esther G., Cluff, Patty A., Lis, Anna E., Franco, Claudia I., Pappas, Athina, Barks, John, Bara, Rebecca, Handel, Shelley, Muran, Geraldine, White, Diane F., Christensen, Mary, Wiggins, Stephanie A., Laptook, Abbot R., Bell, Edward F., Shankaran, Seetha, Boghossian, Nansi S., Wyckoff, Myra H., Kandefer, Sarah, Walsh, Michele, Saha, Shampa, and Higgins, Rosemary

Published
2018
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50. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support

Author

Caplan, Michael S., Laptook, Abbot R., Hensman, Angelita M., Vieira, Elisa, Little, Emilee, Burke, Robert, Caskey, Melinda, Johnson, Katharine, Alksninis, Barbara, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., McGowan, Elisabeth C., Watson, Victoria E., Ventura, Suzy, Walsh, Michele C., Fanaroff, Avroy A., Hibbs, Anna Marie, Newman, Nancy S., Payne, Allison H., Wilson-Costello, Deanne E., Siner, Bonnie S., Bhola, Monika, Yalcinkaya, Gulgun, Friedman, Harriet G., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Alexander, Barbara, Grisby, Cathy, Gratton, Teresa L., Steichen, Jean J., Fischer, Estelle E., Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Tepe, Stacey, Yolton, Kimberly, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Malcolm, William F., Ashley, Patricia L., Fisher, Kimberley A., Finkle, Joanne, Gustafson, Kathryn E., Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Wereszczak, Janice, Carlton, David P., Hale, Ellen C., Adams-Chapman, Ira, Loggins, Yvonne, Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Papile, Lu-Ann, Wilson, Leslie Dawn, Herron, Dianne E., Gunn, Susan, Smiley, Lucy, Hines, Abbey C., Nelin, Leif D., Jadcherla, Sudarshan R., Sánchez, Pablo J., Luzader, Patricia, Besner, Gail E., Parikh, Nehal A., Wallace, Dennis, Gantz, Marie G., Newman, Jamie E., O'Donnell Auman, Jeanette, Crawford, Margaret, Huitema, Carolyn M. Petrie, Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Hintz, Susan R., Proud, Melinda S., Bentley, Barbara, DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Krueger, Casey E., Weiss, Hali E., Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Biasini, Fred J., Johnston, Kristen C., Patterson, Cryshelle S., Phillips, Vivien A., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Ellsbury, Dan L., Colaizy, Tarah T., Brumbaugh, Jane E., Widness, John A., Johnson, Karen J., Walker, Jacky R., Campbell, Donia B., Eastman, Diane L., Watterberg, Kristi L., Lowe, Jean R., Fuller, Janell F., Ohls, Robin K., Lacy, Conra Backstrom, Duncan, Andrea F., Schmidt, Barbara, Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl T., Guillet, Ronnie, Lakshminrusimha, Satyan, Reynolds, Anne Marie, Jensen, Rosemary L., Merzbach, Joan, Myers, Gary J., Williams, Ashley, Yost, Kelley, Zorn, William, Wynn, Karen, Maffett, Deanna, Prinzing, Diane, Hunn, Julianne, Guilford, Stephanie, Osman, Farooq, Rowan, Mary, Sacilowski, Michael G., Wadkins, Holly I.M., Bowman, Melissa, Kennedy, Kathleen A., Arldt-McAlister, Julie, Burson, Katrina, Duncan, Andrea Freeman, Garcia, Carmen, Harris, Beverly Foley, John, Janice, Jones, Patrick M., Lillie, Layne M., Martin, Karen, Martin, Sara C., McDavid, Georgia E., Rodgers, Shawna, Siddiki, Saba, Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Wyckoff, Myra, Brion, Luc P., Vasil, Diana M., Chen, Lijun, Heyne, Roy J., Adams, Sally S., Madden, Linda A., Heyne, Elizabeth, Guzman, Alicia, Torres, Lizette E., Boatman, Catherine Twell, Pappas, Athina, Bara, Rebecca, Goldston, Laura A., Barks, John, Christensen, Mary, Wiggins, Stephanie, White, Diane, James, Jennifer, Munson, David, DeMauro, Sara B., Langer, John C., Dworetz, April R., Natarajan, Girija, Bidegain, Margarita, Fortney, Christine A., Seabrook, Ruth, Vohr, Betty R., Tyson, Jon E., Bell, Edward F., Shankaran, Seetha, Higgins, Rosemary D., Das, Abhik, Stoll, Barbara J., and Kirpalani, Haresh

Published
2017
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