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2. Large-scale IgM and IgG SARS-CoV-2 serological screening among healthcare workers with a low infection prevalence based on nasopharyngeal swab tests in an Italian university hospital: Perspectives for public health

Author

Vimercati, Luigi, Stefanizzi, Pasquale, De Maria, Luigi, Caputi, Antonio, Cavone, Domenica, Quarato, Marco, Gesualdo, Loreto, Lopalco, Pier Luigi, Migliore, Giovanni, Sponselli, Stefania, Graziano, Giusi, Larocca, Angela Maria Vittoria, and Tafuri, Silvio

Published
2021
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6. Molecular Characterization of Coxsackievirus B5 Isolates from Sewage, Italy 2016–2017

Author

Fontana, Stefano, Fiore, Stefano, Buttinelli, Gabriele, Amato, Concetta, Veronesi, Licia, Zoni, Roberta, Triassi, Maria, Pennino, Francesca, Giammanco, Giovanni Maurizio, De Grazia, Simona, Cicala, Antonella, Siragusa, Angelo, Gamper, Sabine, Spertini, Silvia, Castiglia, Paolo, Cossu, Andrea, Germinario, Cinzia, Larocca, Angela Maria Vittoria, and Stefanelli, Paola

Published
2019
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10. Antispike Immunoglobulin-G (IgG) Titer Response of SARS-CoV-2 mRNA-Vaccine (BNT162b2): A Monitoring Study on Healthcare Workers

Author

Inchingolo, Alessio Danilo, primary, Malcangi, Giuseppina, additional, Ceci, Sabino, additional, Patano, Assunta, additional, Corriero, Alberto, additional, Azzollini, Daniela, additional, Marinelli, Grazia, additional, Coloccia, Giovanni, additional, Piras, Fabio, additional, Barile, Giuseppe, additional, Settanni, Vito, additional, Mancini, Antonio, additional, De Leonardis, Nicole, additional, Garofoli, Grazia, additional, Palmieri, Giulia, additional, Isacco, Ciro Gargiulo, additional, Rapone, Biagio, additional, Jones, Megan, additional, Bordea, Ioana Roxana, additional, Tartaglia, Gianluca Martino, additional, Scarano, Antonio, additional, Lorusso, Felice, additional, Macchia, Luigi, additional, Larocca, Angela Maria Vittoria, additional, Tafuri, Silvio, additional, Migliore, Giovanni, additional, Brienza, Nicola, additional, Dipalma, Gianna, additional, and Inchingolo, Francesco, additional

Published
2022
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12. Effectiveness of SARS-CoV-2 Vaccines for Short- and Long-Term Immunity: A General Overview for the Pandemic Contrast

Author

Inchingolo, Alessio Danilo, primary, Malcangi, Giuseppina, additional, Ceci, Sabino, additional, Patano, Assunta, additional, Corriero, Alberto, additional, Vimercati, Luigi, additional, Azzollini, Daniela, additional, Marinelli, Grazia, additional, Coloccia, Giovanni, additional, Piras, Fabio, additional, Barile, Giuseppe, additional, Settanni, Vito, additional, Mancini, Antonio, additional, De Leonardis, Nicole, additional, Garofoli, Grazia, additional, Palmieri, Giulia, additional, Isacco, Ciro Gargiulo, additional, Rapone, Biagio, additional, Scardapane, Arnaldo, additional, Curatoli, Luigi, additional, Quaranta, Nicola, additional, Ribezzi, Mario, additional, Massaro, Maria, additional, Jones, Megan, additional, Bordea, Ioana Roxana, additional, Tartaglia, Gianluca Martino, additional, Scarano, Antonio, additional, Lorusso, Felice, additional, Macchia, Luigi, additional, Larocca, Angela Maria Vittoria, additional, Aityan, Sergey Khachatur, additional, Tafuri, Silvio, additional, Stefanizzi, Pasquale, additional, Migliore, Giovanni, additional, Brienza, Nicola, additional, Dipalma, Gianna, additional, Favia, Gianfranco, additional, and Inchingolo, Francesco, additional

Published
2022
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13. Prospective, case-control study of serological response after two doses of BNT162b2 anti-SARS-CoV-2 mRNA vaccine in transfusion-dependent thalassemic patients

Author

SGHERZA, NICOLA, primary, Zucano, Stefania, additional, Vitucci, Angelantonio, additional, Palma, Antonio, additional, Tarantini, Francesco, additional, Campanale, Daniela, additional, Vimercati, Luigi, additional, Larocca, Angela Maria Vittoria, additional, Visceglie, Domenico, additional, Acquafredda, Amalia, additional, Ostuni, Angelo, additional, Di Gennaro, Daniela, additional, Vitucci, Carmen, additional, Tafuri, Silvio, additional, and Musto, Pellegrino, additional

Published
2022
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14. Immune response to one dose of BNT162b2 mRNA Covid-19 vaccine followed by SARS-CoV-2 infection: An Italian prospective observational study

Author

Stefanizzi, Pasquale, primary, Larocca, Angela Maria Vittoria, additional, Martinelli, Andrea, additional, Soldano, Savino, additional, Dell'Aera, Maria, additional, Migliore, Giovanni, additional, Germinario, Cinzia Annatea, additional, Vimercati, Luigi, additional, Tafuri, Silvio, additional, and Bianchi, Francesco Paolo, additional

Published
2022
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16. Serological Response Following BNT162b2 Anti-Sars-Cov-2 mRNA Vaccination in Hematopoietic Stem Cell Transplantation Patients

Author

Attolico, Imma, primary, Tarantini, Francesco, additional, Carluccio, Paola, additional, Schifone, Claudia, additional, Delia, Mario, additional, Gagliardi, Vito Pier, additional, Perrone, Tommasina, additional, Gaudio, Francesco, additional, Longo, Chiara, additional, Giordano, Annamaria, additional, Sgherza, Nicola, additional, Curci, Paola, additional, Rizzi, Rita, additional, Ricco, Alessandra, additional, Russo Rossi, Antonella Vita, additional, Albano, Francesco, additional, Larocca, Angela Maria Vittoria, additional, Vimercati, Luigi, additional, Tafuri, Silvio, additional, and Musto, Pellegrino, additional

Published
2021
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17. Serological Response to BNT162b2 Anti-Sars-Cov-2 mRNA Vaccine in Patients with Transfusion Dependent Thalassemia

Author

Zucano, Stefania, primary, Tarantini, Francesco, additional, Vitucci, Angelantonio, additional, Palma, Antonio, additional, Campanale, Daniela, additional, Vimercati, Luigi, additional, Larocca, Angela Maria Vittoria, additional, Visceglie, Domenico, additional, Acquafredda, Amalia, additional, Tafuri, Silvio, additional, and Musto, Pellegrino, additional

Published
2021
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18. Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test

Author

Paradiso, Angelo Virgilio, primary, De Summa, Simona, additional, Silvestris, Nicola, additional, Tommasi, Stefania, additional, Tufaro, Antonio, additional, Larocca, Angela Maria Vittoria, additional, D’Addabbo, Vincenzo, additional, Raffaele, Donata, additional, Cafagna, Vito, additional, Garrisi, Vito Michele, additional, and De Palma, Giuseppe, additional

Published
2021
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21. Medium-Long Term Immunogenicity of BNT162b2 mRNA COVID-19 Vaccine: A Retrospective Cohort Study

Author

Bianchi, Francesco Paolo, primary, Stefanizzi, Pasquale, additional, Germinario, Cinzia Annatea, additional, Migliore, Giovanni, additional, Vimercati, Luigi, additional, Martinelli, Andrea, additional, Lobifaro, Annamaria, additional, Diella, Giusi, additional, Larocca, Angela Maria Vittoria, additional, Group, Control Room Working, additional, and Tafuri, Silvio, additional

Published
2021
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22. COVID-19 SCREENING AND MONITORING OF ASYMPTOMATIC HEALTH WORKERS WITH A RAPID SEROLOGICAL TEST

Author

Paradiso, Angelo Virgilio, primary, De Summa, simona, additional, Silvestris, Nicola, additional, Tommasi, Stefania, additional, Tufaro, Antonio, additional, De Palma, Giuseppe, additional, Larocca, Angela Maria Vittoria, additional, D'Addabbo, Vincenzo, additional, Raffaele, Donata, additional, Cafagna, Vito, additional, and Garrisi, Vito Michele, additional

Published
2020
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23. RAPID SEROLOGICAL TESTS HAVE A ROLE IN ASYMPTOMATIC HEALTH WORKERS COVID-19 SCREENING

Author

Paradiso, Angelo Virgilio, primary, Summa, SimonaDe, additional, Silvestris, Nicola, additional, Tommasi, Stefania, additional, Tufaro, Antonio, additional, De Palma, Giuseppe, additional, Larocca, Angela Maria Vittoria, additional, Chironna, Maria, additional, D’Addabbo, Vincenzo, additional, Raffaele, Donata, additional, Cafagna, Vito, additional, and Garrisi, Vito, additional

Published
2020
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25. Medium-to-Long-Term Immunogenicity of BNT162b2 mRNA COVID-19 Vaccine: A Retrospective Cohort Study.

Author

Bianchi, Francesco Paolo, Stefanizzi, Pasquale, Germinario, Cinzia Annatea, Migliore, Giovanni, Vimercati, Luigi, Martinelli, Andrea, Lobifaro, Annamaria, Diella, Giusy, Larocca, Angela Maria Vittoria, and Tafuri, Silvio

Subjects
MEDICAL personnel, IMMUNE response, COVID-19 vaccines, VACCINATION status, COHORT analysis
Abstract

To deal with the COVID-19 pandemic, a mass vaccination campaign was started in European countries on 27 December 2020. The first vaccine available to immunize healthcare workers (HCWs) was the BNT162b2 mRNA COVID-19 vaccine. While many studies have shown a high antibody response after the second vaccine dose, antibody persistence over the medium-to-long term has yet to be evaluated. The medium-to-long-term persistence of anti-SARS-CoV-2 antibodies was determined in a sample of fully vaccinated HCWs at Bari Policlinico General Hospital, Italy. This is a observational cohort study. HCWs who completed the immunization basal cycle were screened for anti-SARS-CoV-2 IgG on days 15, 30, 60, 90, and 120 after the second vaccine dose. At each time point, >99% of the screened HCWs were seroprotected. While the geometric mean titer initially declined over time, by 60 days the titer had stabilized. Older subjects seem to lose IgG faster than younger ones. The immunogenicity conferred by the vaccine provides further evidence that it is an essential weapon in efforts to bring the COVID-19 pandemic under control. Accordingly, strict measures should be implemented, ranging from the mandatory vaccination of HCWs to strong incentives aimed at achieving vaccination of the large majority of the overall population. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Serological response following BNT162b2 anti‐SARS‐CoV‐2 mRNA vaccination in haematopoietic stem cell transplantation patients.

Author

Attolico, Immacolata, Tarantini, Francesco, Carluccio, Paola, Schifone, Claudia Pia, Delia, Mario, Gagliardi, Vito Pier, Perrone, Tommasina, Gaudio, Francesco, Longo, Chiara, Giordano, Annamaria, Sgherza, Nicola, Curci, Paola, Rizzi, Rita, Ricco, Alessandra, Russo Rossi, Antonella, Albano, Francesco, Larocca, Angela Maria Vittoria, Vimercati, Luigi, Tafuri, Silvio, and Musto, Pellegrino

Subjects
HEMATOPOIETIC stem cell transplantation, MYELOFIBROSIS, SARS-CoV-2, CHRONIC leukemia, VACCINATION, COVID-19 vaccines
Abstract

In G1, all patients, allogeneic recipients and autologous recipients had significantly lower antibody levels than HC, whereas no differences were found in G2. Among the patients vaccinated >5 years after HSCT, allogeneic recipients had antibody titres comparable to HC; in contrast, autologous recipients had significantly lower titres than HC. Keywords: stem cell transplantation; severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination; seroconversion EN stem cell transplantation severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination seroconversion 928 931 4 02/14/22 20220215 NES 220215 Adult patients with haematological malignancies (HM) and coronavirus disease 2019 (COVID-19) have a higher mortality than healthy subjects.1-3 In particular, haematopoietic stem-cell transplantation (HSCT) recipients have a poor prognosis,4,5 strongly supporting the role of vaccination. Serological response following BNT162b2 anti-SARS-CoV-2 mRNA vaccination in haematopoietic stem cell transplantation patients. [Extracted from the article]

Published
2022
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29. Lack of immunity against rubella among Italian young adults

Author

Germinario Cinzia, Gallone Maria Serena, Gallone Maria Filomena, Tafuri Silvio, and Larocca Angela Maria Vittoria

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, 030106 microbiology, Antibodies, Viral, Vaccination strategy, Rubella, Measles, Congenital Rubella, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Seroepidemiologic Studies, Immunity, Internal medicine, medicine, Humans, Public Health Surveillance, Serosurvey, 030212 general & internal medicine, General hospital, Young adult, Rubella immunity status, Aged, business.industry, Public health, Age Factors, Middle Aged, medicine.disease, Rubella elimination, Infectious Diseases, Italy, Immunoglobulin G, Tropical medicine, Immunology, Female, Erratum, business, Rubella virus, Biomarkers, Research Article
Abstract

Background To support the evaluation of the 2010-15 National Plan for Measles and Congenital Rubella Elimination, the authors designed and performed a serosurveillance survey to verify the immunity/susceptibility rate against rubella among Apulian young adults. Methods The study was carried out from May 2011 to June 2012 in the Department of Transfusion Medicine/Blood Bank of Policlinico General Hospital in Bari. Subjects were enrolled by a convenience sampling. For each enrolled patient a 5 ml serum sample was collected and tested for anti-rubella IgG. The geometrical means (GMT) of anti-rubella IgG was calculated. T student test or ANOVA test, when appropriate, was used to compare the means of age per gender and GMT of anti-rubella IgG titres per age classes. Chi-square test was used to compare the proportion of anti-rubella IgG positive subjects per gender and per age classes. For all tests, a p value

Published
2017
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30. Long-term Immunogenicity of Measles Vaccine: An Italian Retrospective Cohort Study.

Author

Bianchi, Francesco Paolo, Stefanizzi, Pasquale, Nitto, Sara De, Larocca, Angela Maria Vittoria, Germinario, Cinzia, Tafuri, Silvio, and De Nitto, Sara

Subjects
MEASLES vaccines, MEDICAL students, MMR vaccines, IMMUNOGLOBULIN G, IMMUNOLOGIC memory, ANTI-vaccination movement, MEASLES prevention, RUBELLA, IMMUNIZATION, IMMUNOGLOBULINS, MEASLES, RETROSPECTIVE studies, MEDICAL protocols, PARAMYXOVIRUSES, RNA viruses, MUMPS, VIRAL antibodies
Abstract

Background: Levels of antibodies induced by the measles virus-containing vaccine have been shown to decline over time, but there is no formal recommendation about testing immunized subjects (in particular, healthcare workers [HCWs]) to investigate the persistence of measles immunoglobulin G (IgG).Methods: This study aims to evaluate the long-term immunogenicity of measles vaccine in a sample of medical students and residents of the University of Bari who attended the Hygiene Department for a biological risk assessment (April 2014-June 2018).Results: Two thousand immunized (2 doses of measles-mumps-rubella [MMR] vaccine) students and residents were tested; 305 of these (15%) did not show protective anti-measles IgG. This proportion was higher among subjects who received vaccination at ≤15 months (20%) than in those who received vaccination at 16-23 months (17%) and at ≥24 months (10%) (P < .0001). After an MMR vaccine booster dose, we noted a seroconversion of 74% of seronegative HCWs. The overall seroconversion rate after a second dose (booster) was 93%. No serious adverse events were noted after the booster doses.Conclusions: An important proportion of subjects immunized for measles do not show a protective IgG titer in the 10 years after vaccination. Our management strategy seems consistent with the purpose of evidencing immunological memory. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Lack of immunity against rubella among Italian young adults.

Author

Serena, Gallone Maria, Filomena, Gallone Maria, Vittoria, Larocca Angela Maria, Cinzia, Germinario, Silvio, Tafuri, Gallone, Maria Serena, Gallone, Maria Filomena, Larocca, Angela Maria Vittoria, Germinario, Cinzia, and Tafuri, Silvio

Subjects
MEASLES vaccines, VACCINATION, RUBELLA vaccines, DISEASES in young adults, CHI-squared test, WOMEN'S health, AGE distribution, EPIDEMIOLOGICAL research, IMMUNOGLOBULINS, PUBLIC health surveillance, RNA viruses, RUBELLA, VIRAL antibodies, PREVENTION
Abstract

Background: To support the evaluation of the 2010-15 National Plan for Measles and Congenital Rubella Elimination, the authors designed and performed a serosurveillance survey to verify the immunity/susceptibility rate against rubella among Apulian young adults.Methods: The study was carried out from May 2011 to June 2012 in the Department of Transfusion Medicine/Blood Bank of Policlinico General Hospital in Bari. Subjects were enrolled by a convenience sampling. For each enrolled patient a 5 ml serum sample was collected and tested for anti-rubella IgG. The geometrical means (GMT) of anti-rubella IgG was calculated. T student test or ANOVA test, when appropriate, was used to compare the means of age per gender and GMT of anti-rubella IgG titres per age classes. Chi-square test was used to compare the proportion of anti-rubella IgG positive subjects per gender and per age classes. For all tests, a p value <0.05 was considered as significant.Results: At the end of the study 1764 subjects were enrolled, 1362 (77.2%) of which were male. The mean age was 38.4 ± 11.7 years (range: 17-65). 86.7% (95% CI = 85.0-88.2) had a positive titre of anti-rubella IgG. GMT of anti-rubella IgG titre was 4.3. The proportion of positive subjects was of 76.8% (n = 279/363; 95% CI = 72.2-81.1) in persons aged 18-26 years; 88.1% (n = 310/352; 95% CI = 84.2-91.3) in 27-35 year-old people; 88.5% (n = 464/524; 95% CI = 85.5-91.1) in 36-45 year-old people; 90.7% (n = 350/386; 95% CI = 87.3-93.4) among people aged 46-55 years and 90.6% (n = 126/139; 95% CI = 84.5-94.9) in 55-65 year-old people (Chi-square = 39.7; p < 0.0001). GMT of anti-rubella IgG titre was 4.3 (4.3 in male and 4.2 in female, t = 2.2; p = 0.03) and seems to differ dividing the enrolled subjects by age group (F = 14.3; p < 0.0001).Conclusions: According to our data, too many women of child-bearing age are still unprotected from rubella in the elimination era and in this scenario the public health efforts should be oriented to catch-up activities. [ABSTRACT FROM AUTHOR]

Published
2017
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34. Diagnostic and Prognostic Role of Preoperative Circulating CA 15-3, CA 125, and Beta-2 Microglobulin in Renal Cell Carcinoma

Author

Lucarelli, Giuseppe, primary, Ditonno, Pasquale, additional, Bettocchi, Carlo, additional, Vavallo, Antonio, additional, Rutigliano, Monica, additional, Galleggiante, Vanessa, additional, Larocca, Angela Maria Vittoria, additional, Castellano, Giuseppe, additional, Gesualdo, Loreto, additional, Grandaliano, Giuseppe, additional, Selvaggi, Francesco Paolo, additional, and Battaglia, Michele, additional

Published
2014
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35. Serum sarcosine is a risk factor for progression and survival in patients with metastatic castration-resistant prostate cancer

Author

Lucarelli, Giuseppe, primary, Ditonno, Pasquale, additional, Bettocchi, Carlo, additional, Spilotros, Marco, additional, Rutigliano, Monica, additional, Vavallo, Antonio, additional, Galleggiante, Vanessa, additional, Fanelli, Margherita, additional, Larocca, Angela Maria Vittoria, additional, Germinario, Cinzia Annatea, additional, Maiorano, Eugenio, additional, Selvaggi, Francesco Paolo, additional, and Battaglia, Michele, additional

Published
2013
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38. Molecular Characterization of Coxsackievirus B5 Isolates from Sewage, Italy 2016–2017

Author

Gabriele Buttinelli, Concetta Amato, Paolo Castiglia, Stefano Fiore, Paola Stefanelli, Licia Veronesi, Simona De Grazia, Antonella Cicala, Angela Maria Vittoria Larocca, Andrea Cossu, Francesca Pennino, Silvia Spertini, Sabine Gamper, Giovanni M. Giammanco, Roberta Zoni, Stefano Fontana, Angelo Siragusa, Maria Triassi, Cinzia Germinario, Fontana, S., Fiore, S., Buttinelli, G., Amato, C., Veronesi, L., Zoni, R., Triassi, M., Pennino, F., Giammanco, G. M., De Grazia, S., Cicala, A., Siragusa, Danilo, Gamper, S., Spertini, S., Castiglia, P., Cossu, A., Germinario, C., Larocca, A. M. V., Stefanelli, P., Fontana, Stefano, Fiore, Stefano, Buttinelli, Gabriele, Amato, Concetta, Veronesi, Licia, Zoni, Roberta, Triassi, Maria, Pennino, Francesca, Giammanco, Giovanni Maurizio, De Grazia, Simona, Cicala, Antonella, Siragusa, Angelo, Gamper, Sabine, Spertini, Silvia, Castiglia, Paolo, Cossu, Andrea, Germinario, Cinzia, Larocca, Angela Maria Vittoria, and Stefanelli, Paola

Subjects
0301 basic medicine, Settore MED/07 - Microbiologia E Microbiologia Clinica, Epidemiology, Viral protein, Health, Toxicology and Mutagenesis, viruses, 030106 microbiology, Sewage, 010501 environmental sciences, Biology, Coxsackievirus, medicine.disease_cause, Brief Communication, 01 natural sciences, 03 medical and health sciences, Viral Proteins, Phylogenetic analysi, Non-polio enteroviruse, Phylogenetics, Virology, medicine, Phylogeny, 0105 earth and related environmental sciences, Polioviruse, Phylogenetic analysis, CV-B5, Phylogenetic tree, business.industry, virus diseases, Non-polio enteroviruses, biology.organism_classification, Enterovirus B, Human, Italy, GenBank, Polioviruses, Coxsackieviru, business, Food Science, Environmental Monitoring
Abstract

Hereby, the partial Viral Protein 1 sequences of Coxsackievirus B5 (CV-B5) from sewage samples, collected in Italy from 2016 to 2017, were compared with those available in GenBank from clinical samples. Phylogenetic analysis highlighted: (I) the predominant circulation of CV-B5 genogroup B in Italy, and (II) the presence of two new sub-genogroups.

Published
2019

39. Antibody response to BNT162b2 SARS-CoV-2 mRNA vaccine is not influenced by AB0 blood group in subjects with transfusion-dependent thalassemia.

Author

Sgherza N, Zucano S, Vitucci A, Palma A, Campanale D, Larocca AMV, Visceglie D, Acquafredda A, and Musto P

Subjects
Antibodies, Viral, Antibody Formation, BNT162 Vaccine, COVID-19 Vaccines, Humans, SARS-CoV-2, Vaccines, Synthetic, mRNA Vaccines, Blood Group Antigens, COVID-19 prevention & control, Thalassemia genetics, Thalassemia therapy
Abstract

Not applicable.

Published
2022
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40. Lesson from an intriguing case of cryoglobulinemia.

Author

Barone M, Licinio R, Amoruso A, Viggiani MT, Larocca AM, and Di Leo A

Subjects
Aged, Antibodies, Viral blood, Hepacivirus genetics, Hepacivirus immunology, Hepatitis C, Chronic blood, Hepatitis C, Chronic diagnosis, Humans, Male, RNA, Viral blood, Cryoglobulinemia diagnosis, Cryoglobulinemia etiology, Hepatitis C, Chronic complications
Abstract

Cryoglobulinemia is a pathological condition usually associated with hepatitis C virus (HCV) chronic liver disease and less commonly with autoimmune or lymphoproliferative disorders. The possible association of cryoglobulinemia with hepatitis B virus (HBV) infection is not widely accepted. In our patient, serum negativity for HCV markers initially led us to consider two other causes of cryoglobulinemia. Myelodysplastic disorders were excluded on the basis of hematological studies, while serum markers for active HBV infection were positive. Surprisingly, the detection of HCV RNA in the cryocrit, even in the absence of anti-HCV antibodies, suggested a pathogenetic role of HCV in this case of cryoglobulinemia. Negative "first level" tests for HCV in the serum do not completely exclude HCV involvement in the pathogenesis of cryoglobulinemia. Analysis of the cryoprecipitate is always essential for diagnosis.

Published
2013
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