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12 results on '"Larsen, Autumn"'

3. Polymeric Pathogen-Like Particles-Based Combination Adjuvants Elicit Potent Mucosal T Cell Immunity to Influenza A Virus

Author

Kingstad-Bakke, Brock, primary, Toy, Randall, additional, Lee, Woojong, additional, Pradhan, Pallab, additional, Vogel, Gabriela, additional, Marinaik, Chandranaik B., additional, Larsen, Autumn, additional, Gates, Daisy, additional, Luu, Tracy, additional, Pandey, Bhawana, additional, Kawaoka, Yoshihoro, additional, Roy, Krishnendu, additional, and Suresh, M., additional

Published
2021
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4. Nano-Emulsion Adjuvant Enhances Cross-presentation by Lipid Body Formation Independent of Glycolysis

Author

Suresh, M, Lee, Woojong, Kingstad-Bakke, Brock, Paulson, Brett, Larsen, Autumn, Overmyer, Katherine, Marinaik, Chandranaik, Dull, Kelly, Toy, Randall, Vogel, Gabriela, Mueller, Katherine, Tweed, Kelsey, Walsh, Alex, Russell, Jason, Saha, Krishanu, Reyes, Leticia, Skala, Melissa, Sauer, John-Demian, Shayakhmetov, Dmitry M, Coon, Joshua, and Roy, Krishnendu

Abstract

Here, we report that a carbomer-based adjuvant, Adjuplex® (ADJ), stimulated robust CD8 T-cell responses to subunit antigens by modulating multiple steps in the cytosolic pathway of cross-presentation, and afforded effective immunity against virus and intracellular bacteria. Cross-presentation induced by TLR agonists requires a critical switch to anabolic metabolism, but ADJ enhanced cross presentation without this metabolic switch in DCs and NLRP3-driven caspase 1 activity. Instead, ADJ induced in DCs, an unique metabolic state, typified by dampened oxidative phosphorylation and basal levels of glycolysis. In the absence of increased glycolytic flux, induction of ROS and lipid bodies (LBs) and alterations in LB composition mediated by ADJ were critical for DC cross-presentation. These findings challenge the prevailing metabolic paradigm by suggesting that DCs can perform effective DC cross-presentation, independent of glycolysis to induce robust T cell-dependent protective immunity to intracellular pathogens. These findings have implications in the rational development of novel adjuvants that promote cross-presentation and elicit potent cell-mediated immunity.

Published
2020
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5. Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells

Author

Lee, Woojong, primary, Kingstad-Bakke, Brock, additional, Paulson, Brett, additional, Larsen, Autumn, additional, Overmyer, Katherine, additional, Marinaik, Chandranaik B., additional, Dulli, Kelly, additional, Toy, Randall, additional, Vogel, Gabriela, additional, Mueller, Katherine P., additional, Tweed, Kelsey, additional, Walsh, Alex J., additional, Russell, Jason, additional, Saha, Krishanu, additional, Reyes, Leticia, additional, Skala, Melissa C., additional, Sauer, John-Demian, additional, Shayakhmetov, Dmitry M., additional, Coon, Joshua, additional, Roy, Krishnendu, additional, and Suresh, M., additional

Published
2021
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9. Carbomer-based Nano-Emulsion Adjuvant Enhances Dendritic Cell Cross-presentation via Lipid Body Formation Independent of Glycolysis

Author

Lee, Woojong, primary, Kingstad-Bakke, Brock, additional, Paulson, Brett, additional, Larsen, Autumn R., additional, Overmyer, Katherine, additional, Marinaik, Chandranaik B., additional, Dulli, Kelly, additional, Toy, Randall, additional, Vogel, Gabriela, additional, Mueller, Katherine P., additional, Tweed, Kelsey, additional, Walsh, Alex J., additional, Russell, Jason, additional, Saha, Krishanu, additional, Reyes, Leticia, additional, Skala, Melissa C., additional, Sauer, John-Demian, additional, Shayakhmetov, Dmitry M., additional, Coon, Joshua, additional, Roy, Krishnendu, additional, and Suresh, M., additional

Published
2020
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12. Sanford School of Medicine Students Go International.

Author

Larsen, Autumn, Sievers, Meaghan, and Beard, Mark

Abstract

The article focuses on a medical service trip to Guatemala organized by the University of South Dakota Sanford School of Medicine (USD SSOM) in partnership with Friends of San Lucas. Topics include the challenges faced due to the COVID-19 pandemic, the planning process for the trip, and the experiences of the medical mission team providing healthcare services in San Lucas Tolíman.

Published
2023

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