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217 results on '"Laszkowska, Monika"'

3. Prevalence of Gastric Precursor Lesions in Countries With Differential Gastric Cancer Burden: A Systematic Review and Meta-analysis

Author

Mülder, Duco T., Hahn, Anne I., Huang, Robert J., Zhou, Margaret J., Blake, Benjamin, Omofuma, Omonefe, Murphy, John D., Gutiérrez-Torres, Daniela S., Zauber, Ann G., O’Mahony, James F., Camargo, M. Constanza, Ladabaum, Uri, Yeh, Jennifer M., Hur, Chin, Lansdorp-Vogelaar, Iris, Meester, Reinier, and Laszkowska, Monika

Published
2024
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8. Factors Associated With Advanced Histological Diagnosis and Upstaging After Endoscopic Submucosal Dissection of Superficial Gastric Neoplasia

Author

Gudenkauf, Franciska J., Mehta, Amit, Ferri, Lorenzo, Aihara, Hiroyuki, Draganov, Peter V., Yang, Dennis J., Jue, Terry L., Munroe, Craig A., Boparai, Eshandeep S., Mehta, Neal A., Bhatt, Amit, Kumta, Nikhil A., Othman, Mohamed O., Mercado, Michael, Javaid, Huma, Aadam, Abdul Aziz, Siegel, Amanda, James, Theodore W., Grimm, Ian S., DeWitt, John M., Novikov, Aleksey, Schlachterman, Alexander, Kowalski, Thomas, Samarasena, Jason, Hashimoto, Rintaro, Chehade, Nabil El Hage, Lee, John G., Chang, Kenneth, Su, Bailey, Ujiki, Michael B., Sharaiha, Reem Z., Carr-Locke, David L., Chen, Alex, Chen, Michael, Chen, Yen-I, Tomizawa, Yutaka, von Renteln, Daniel, Kumbhari, Vivek, Khashab, Mouen A., Bechara, Robert, Karasik, Michael, Patel, Neej J., Fukami, Norio, Nishimura, Makoto, Hanada, Yuri, Song, Louis M. Wong Kee, Laszkowska, Monika, Wang, Andrew Y., Hwang, Joo Ha, Friedland, Shai, Sethi, Amrita, and Ngamruengphong, Saowanee

Published
2023
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11. Endoscopy-Guided High-Pressure Spray “Power-Wash” for Detection of Gastric Intestinal Metaplasia and Dysplasia

Author

Lightdale, Charles J., primary, Tiscornia-Wasserman, Patricia, additional, Sethi, Amrita, additional, Abrams, Julian A., additional, Laszkowska, Monika, additional, Dua, Arshish, additional, Kim, Judith, additional, Soroush, Ali, additional, Zylberberg, Haley M., additional, Nathanson, John T., additional, and Hur, Chin, additional

Published
2024
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13. Efficacy of Endoscopic Submucosal Dissection for Superficial Gastric Neoplasia in a Large Cohort in North America

Author

Ngamruengphong, Saowanee, Ferri, Lorenzo, Aihara, Hiroyuki, Draganov, Peter V., Yang, Dennis J., Perbtani, Yaseen B., Jue, Terry L., Munroe, Craig A., Boparai, Eshandeep S., Mehta, Neal A., Bhatt, Amit, Kumta, Nikhil A., Othman, Mohamed O., Mercado, Michael, Javaid, Huma, Aadam, Abdul Aziz, Siegel, Amanda, James, Theodore W., Grimm, Ian S., DeWitt, John M., Novikov, Aleksey, Schlachterman, Alexander, Kowalski, Thomas, Samarasena, Jason, Hashimoto, Rintaro, Chehade, Nabil El Hage, Lee, John, Chang, Kenneth, Su, Bailey, Ujiki, Michael B., Mehta, Amit, Sharaiha, Reem Z., Carr-Locke, David L., Chen, Alex, Chen, Michael, Chen, Yen-I., Pourmousavi Khoshknab, MirMilad, Wang, Rui, Kerdsirichairat, Tossapol, Tomizawa, Yutaka, von Renteln, Daniel, Kumbhari, Vivek, Khashab, Mouen A., Bechara, Robert, Karasik, Michael, Patel, Neej J., Fukami, Norio, Nishimura, Makoto, Hanada, Yuri, Wong Kee Song, Louis M., Laszkowska, Monika, Wang, Andrew Y., Hwang, Joo Ha, Friedland, Shai, Sethi, Amrita, and Kalloo, Antony N.

Published
2021
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20. Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer

Author

Lumish, Melissa A, primary, Walch, Henry, additional, Maron, Steven B, additional, Chatila, Walid, additional, Kemel, Yelena, additional, Maio, Anna, additional, Ku, Geoffrey Y, additional, Ilson, David H, additional, Won, Elizabeth, additional, Li, Jia, additional, Joshi, Smita S, additional, Gu, Ping, additional, Schattner, Mark A, additional, Laszkowska, Monika, additional, Gerdes, Hans, additional, Jones, David R, additional, Sihag, Smita, additional, Coit, Daniel G, additional, Tang, Laura H, additional, Strong, Vivian E, additional, Molena, Daniela, additional, Stadler, Zsofia K, additional, Schultz, Nikolaus, additional, Janjigian, Yelena Y, additional, and Cercek, Andrea, additional

Published
2023
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21. Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer.

Author

Lumish, Melissa A, Walch, Henry, Maron, Steven B, Chatila, Walid, Kemel, Yelena, Maio, Anna, Ku, Geoffrey Y, Ilson, David H, Won, Elizabeth, Li, Jia, Joshi, Smita S, Gu, Ping, Schattner, Mark A, Laszkowska, Monika, Gerdes, Hans, Jones, David R, Sihag, Smita, Coit, Daniel G, Tang, Laura H, and Strong, Vivian E

Subjects
ESOPHAGOGASTRIC junction, FISHER exact test, GASTRIC diseases, ESOPHAGEAL cancer, DATABASES, GASTROPARESIS
Abstract

Background The rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents a unique entity. This study investigated the clinical and molecular characteristics of early-onset and average-onset esophagogastric cancer. Methods We reviewed the Memorial Sloan Kettering Cancer Center gastric, esophageal, and gastroesophageal junction cancer database. Associations between baseline characteristics and tumor and germline molecular alterations were compared between those with early-onset and average-onset esophagogastric cancer using Fisher exact tests and the Benjamini-Hochberg method for multiple-hypothesis correction. Results We included 1123 patients with early-onset esophagogastric cancer (n = 219; median age = 43 years [range = 18-49 years]) and average-onset esophagogastric cancer (n = 904; median age = 67 years [range = 50-94 years]) treated between 2005 and 2018. The early-onset group had more women (39% vs 28%, P  = .002). Patients with early-onset esophagogastric cancer were more likely to have a gastric primary site (64% vs 44%, P   <  .0001). The signet ring cell and/or diffuse type was 3 times more common in the early-onset esophagogastric cancer group (31% vs 9%, P  < .0001). Early-onsite tumors were more frequently genomically stable (31% vs 18%, P   =  .0002) and unlikely to be microsatellite instability high (2% vs 7%, P   =  .003). After restricting to adenocarcinoma and signet ring cell and/or diffuse type carcinomas, we observed no difference in stage (P  = .40) or overall survival from stage IV diagnosis (median = 22.7 vs 22.1 months, P   =  .78). Conclusions Our study supported a preponderance of gastric primary disease sites, signet ring histology, and genomically stable molecular subtypes in early-onset esophagogastric cancer. Our findings highlight the need for further research to define the underlying pathogenesis and strategies for early detection and prevention. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Prevalence of Enteric Infections in Patients on Immune Checkpoint Inhibitors and Impact on Management and Outcomes.

Author

Magahis, Patrick T, Satish, Deepika, Babady, Ngolela Esther, Kamboj, Mini, Postow, Michael A, Laszkowska, Monika, and Faleck, David M

Subjects
DIAGNOSIS of diarrhea, FECAL analysis, ENTEROCOLITIS, DISEASE progression, DIARRHEA, IMMUNE checkpoint inhibitors, ENDOSCOPIC surgery, RETROSPECTIVE studies, TREATMENT effectiveness, DESCRIPTIVE statistics, RESEARCH funding, IMMUNOSUPPRESSIVE agents, POLYMERASE chain reaction, DATA analysis software, DISEASE management, LONGITUDINAL method, IMMUNOTHERAPY, ENDOSCOPY
Abstract

Background Stool pathogen testing is recommended as part of the initial evaluation for patients with new-onset diarrhea on immune checkpoint inhibitors (ICIs), yet its significance has not been well-studied. We aimed to determine the impact of multiplex gastrointestinal (GI) pathogen PCR testing on the clinical course and use of immunosuppressive therapy in patients who develop diarrhea on ICIs. Methods This retrospective cohort included individuals who underwent GI pathogen panel PCR for diarrhea on ICIs at Memorial Sloan Kettering between 7/2015 and 7/2021. The primary outcome was use of immunosuppressive therapy for suspected immunotherapy-related enterocolitis (irEC). Secondary outcomes included diarrhea severity and endoscopic and histologic disease patterns. Results Among 521 ICI-treated patients tested for GI pathogens, 61 (11.7%) had a positive PCR. Compared to patients without detectable infections, patients with infections had more frequent grades 3-4 diarrhea (37.7% vs. 19.6%, P <.01) and colitis (39.3% vs. 14.7%, P <.01). However, patients with infections did not have higher rates of persistent or recurrent diarrhea and were less likely to receive steroids (P <.01) and second-line immunosuppressive agents (P =.03). In 105 patients with lower endoscopy, similar trends were observed and no differences in endoscopic severity or histologic patterns were noted between groups. Conclusions GI infections in ICI-treated patients presenting with diarrhea are linked to more severe but self-limited clinical presentations and may be optimally treated with observation and supportive care alone. Routine and timely stool pathogen testing may help avert unnecessary empiric immunosuppression for suspected irEC, which has been linked to blunted antitumor responses and numerous adverse effects. [ABSTRACT FROM AUTHOR]

Published
2024
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31. A Novel Microbiome Signature in Gastric Cancer

Author

Abate, Miseker, primary, Vos, Elvira, additional, Gonen, Mithat, additional, Janjigian, Yelena Y., additional, Schattner, Mark, additional, Laszkowska, Monika, additional, Tang, Laura, additional, Maron, Steven B., additional, Coit, Daniel G., additional, Vardhana, Santosh, additional, Vanderbilt, Chad, additional, and Strong, Vivian E., additional

Published
2022
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33. ENDOSCOPY-GUIDED HIGH-PRESSURE SPRAY “POWER-WASH” TO OBTAIN CYTOPATHOLOGY FOR DETECTION OF GASTRIC INTESTINAL METAPLASIA: A PROOF-OF-CONCEPT STUDY

Author

Lightdale, Charles J., primary, Tiscornia-Wasserman, Patricia, additional, Sethi, Amrita, additional, Abrams, Julian A., additional, Laszkowska, Monika, additional, Dua, Arshish, additional, Kim, Judith, additional, Soroush, Ali, additional, Zylberberg, Haley M., additional, Nathanson, John T., additional, and Hur, Chin, additional

Published
2022
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36. Mo1237 DIFFERENTIAL PROGRESSION OF SUBTYPES OF INTESTINAL METAPLASIA AND DYSPLASIA TO GASTRIC CANCER: A SYSTEMATIC REVIEW AND META-ANALYSES

Author

Hahn, Anne I., Mülder, Duco T., Huang, Robert J., Zhou, Margaret J., Blake, Benjamin, Omofuma, Omonefe, Murphy, John D., Gutiérrez-Torres, Daniela S., Zauber, Ann G., O'Mahony, James F., Camargo, M. Constanza, Ladabaum, Uri, Yeh, Jennifer M., Hur, Chin, Lansdorp-Vogelaar, Iris, Meester, Reinier G., and Laszkowska, Monika

Published
2024
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40. Mo1246 DIFFERENCES IN GENETIC ANCESTRY AND PRESENCE OF GASTRIC PRECURSOR LESIONS IN INDIVIDUALS WITH EARLY AND AVERAGE ONSET GASTRIC CANCER

Author

Magahis, Patrick T., Cornet, Nicole, Tang, Laura H., Aurora, Kanika, Hingorani, Neha, King, Stephanie, Markowitz, Arnold J., Schattner, Mark A., Shimada, Shoji, Maron, Steven B., Vardhana, Santosha, Lumish, Melissa A., Cercek, Andrea, Janjigian, Yelena, Coit, Daniel, Mendelsohn, Robin, Berger, Michael, Strong, Vivian E., Stadler, Zsofia, and Laszkowska, Monika

Published
2024
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