Search

Luca Imperatori,1 Damiano Giardini,2 Gino Latini,2 Giuseppe Migliori,2 Claudio Blasi,3 Feisal Bunkheila,3 Cesare Breschi,4 Rodolfo Mattioli,1 Silvia Pelliccioni,1 Carmen Laurino,5 Maria Vadalà,5 Beniamino Palmieri,5 Tommaso Iannitti6 1UOC Oncologia Medica Azienda Ospedaliera Ospedali Riuniti Marche Nord, Fano, Italy; 2UOC Otorinolaringoiatria Az. Ospedaliera Ospedali Riuniti Marche Nord, Fano, Italy; 3UOC Radioterapia Az. Ospedaliera Ospedali Riuniti Marche Nord, Fano, Italy; 4UOC Anestesia e Rianimazione Az. Ospedaliera Ospedali Riuniti Marche Nord, Fano, Italy; 5Department of General Surgery and Surgical Specialties, Surgical Clinic, University of Modena and Reggio Emilia Medical School, Modena, Italy; 6KWS BioTest, Marine View Office Park, Portishead, Somerset, UK Background: Neoplasms of the head and neck represent approximately 5% of cancers and they require complex multidisciplinary clinical management. Desmodium adscendens (Desmodium) is a plant that possesses anti-allergic, antioxidant and hepato-protective properties. Lithothamnium calcareum (Lithothamnium) is a calcified seaweed that possesses remineralization properties and the ability to maintain homeostasis.Aim: In this single-arm study, we investigated the efficacy of a combination therapy based on Desmovit® which contains Desmodium and Lithothamnium, and chemotherapy in patients with head and neck cancer.Methods: Twelve patients with histological or cytological diagnosis of stage IV head and neck cancer were enrolled in this study that was approved by the ethics committee of the Unità Operativa Complessa (UOC) di Oncologia Medica Azienda Ospedaliera Ospedali Riuniti Marche Nord and followed the Declaration of Helsinki guidelines. The patients were monitored by investigation of the performance status according to the Glasgow Prognostic Score (GPS), which evaluates the plasma level of C-reactive protein and albumin levels, and the Eastern Cooperative Oncology Group (ECOG) examination. Pain and fatigue were also monitored using the visual analog scale and visual analog fatigue scale, respectively. All the above parameters were assessed biweekly to week 10.Results: GPS, ECOG, and albumin remained stable throughout the study with a trend towards a decrease in GPS and albumin at week 10 post-treatment. Pain significantly improved at week 8 (P

OBJECTIVE: Early childhood caries is a common condition that poses a serious risk to children's health because it can progress quickly, resulting in pain, abscesses, and a general decline in health. As a result, invasive therapies are needed, which call for highly skilled personnel. This systematic review of the literature aims to identify the most recent and widely applied early childhood caries (ECC) prevention and treatment approaches. Only substances that act topically and minimally invasive interventions were considered. MATERIALS AND METHODS: The database search was restricted to randomized clinical trials completed within the last five years, specifically those that examined the following procedures: sodium fluoride (NaF) varnish, alternative restorative technique (ART), nano-silver fluoride, silver diamine fluoride, and silver modified atraumatic restorative treatment sealants (SMART). RESULTS: A total of 815 articles were found. After removing duplicates, 584 articles were included, and 567 of them were excluded due to not meeting the predefined inclusion criteria. CONCLUSIONS: Every method considered has been proven to be successful in halting the progression of ECC and is well-liked by patients, even those who are unwilling to cooperate, as well as by parents. The most common unfavorable effect of SDF is irreversible black discoloration in treated tooth surfaces, but this is typically not a problem. They are all low-cost, minimally invasive techniques that might also be widely used in large communities and low socioeconomic settings. [ABSTRACT FROM AUTHOR]

Gut 2003;52:1764-1767 Background: Hereditary non-polyposis colorectal cancer (HNPCC) (Lynch cancer family syndrome I (LCFS1) and II (LCFS2)) is one of the most common hereditary cancer disorders. HNPCC results from dominantly [...]

• Two Choline-AA based ILs were synthetized using an innovative synthetic route. • [Cho][Gly] and [Cho][Pro] were characterized by IR spectroscopy. • [Cho][Gly] and [Cho][Pro] were diluted with DMSO and tested for CO 2 absorption. • Operando IR setup monitored CO 2 -ILs chemical interaction and CO 2 concentration. • Two different mechanisms of reaction were identified on [Cho][Gly] and [Cho][Pro]. Tackling global warming through the reduction of greenhouse gases is a key challenge mankind is called to face in the close future. Carbon dioxide is one of the main causes of such temperature increase, thus avoiding its release in the atmosphere through capture and/or utilization strategies is a valuable tool to limit greenhouse effect. Presently, the applied technology for sequestrating CO 2 relies on its reaction with amines in aqueous solutions, giving rise to the formation of carbamates and carbonates. However, due to the energy intensive release step, toxicity and corrosiveness, amine scrubbing could not represent a long-term solution in CO 2 capture. Ionic liquids (ILs), organic salts in the liquid state near room temperature, are a class of emerging materials with a great potential towards CO 2 capture. Recently the combination of the choline cation with amino acids based anions gave rise to a wide set of bio-inspired ILs with low toxicity, that, due to the presence of amino groups in the amino acid moiety, are optimal candidates for CO 2 capture. In the present work, two choline-amino acids ILs were synthesized, containing glycine and proline, according to an innovative procedure, overcoming some drawbacks proper of the classical methods. A throughout IR operando study of the CO 2 absorption process in these amino acids based ILs was performed. Even though elementary reactions are the same for all the investigated systems, different absorption pathways were recognized depending on the amino acid based anion. The reversibility of the absorption process differs between the two systems as well, further remarking the role played by the selected amino acid in the overall absorption performances. Such fundamental information, still missing in the literature, will contribute to rationally develop choline-amino acids ILs with optimal CO 2 absorption/activation properties. [ABSTRACT FROM AUTHOR]